Find cheap American Airlines flights to Des Moines
RDU — DSM
Nov 3 — Nov 101
Round-trip
1 adult, Economy
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Cheapest American Airlines flights from USA to Des MoinesExplore the most affordable American Airlines flight options available from USA to Des Moines. Find the lowest fares with prices last updated on October 4, 2026.
Explore the most affordable American Airlines flight options available from USA to Des Moines. Find the lowest fares with prices last updated on October 4, 2026.
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2210:40 pm -
Nonstop1h 34m
Mon 10/267:31 pm -
Nonstop1h 38m
Deal found 9/30![American Airlines logo]()
$237
This American Airlines deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/217:20 am -
Nonstop1h 35m
Sun 11/229:25 am -
Nonstop1h 49m
Deal found 10/3![American Airlines logo]()
$277
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3010:40 pm -
Nonstop1h 34m
Fri 11/67:23 am -
Nonstop1h 47m
Deal found 10/1![American Airlines logo]()
$278
Best American Airlines flights from USA to Des MoinesDiscover carefully curated American Airlines flight deals from USA to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 4, 2026.
Discover carefully curated American Airlines flight deals from USA to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 4, 2026.
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:17 am -
Nonstop1h 39m
Thu 11/57:26 pm -
Nonstop1h 47m
Deal found 9/29![American Airlines logo]()
$237
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/510:53 pm -
Nonstop1h 33m
Sat 11/79:25 am -
Nonstop1h 45m
Deal found 9/30![American Airlines logo]()
$237
This American Airlines deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/217:20 am -
Nonstop1h 35m
Sun 11/229:25 am -
Nonstop1h 49m
Deal found 10/3![American Airlines logo]()
$277
Direct American Airlines flights from USA to Des MoinesExplore non-stop American Airlines flight options from USA to Des Moines based on user searches, and compare prices and availability for your desired travel dates. Data last updated October 4, 2026.
Explore non-stop American Airlines flight options from USA to Des Moines based on user searches, and compare prices and availability for your desired travel dates. Data last updated October 4, 2026.
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2210:40 pm -
Nonstop1h 34m
Mon 10/267:31 pm -
Nonstop1h 38m
Deal found 9/30![American Airlines logo]()
$237
This American Airlines deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/217:20 am -
Nonstop1h 35m
Sun 11/229:25 am -
Nonstop1h 49m
Deal found 10/3![American Airlines logo]()
$277
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3010:40 pm -
Nonstop1h 34m
Fri 11/67:23 am -
Nonstop1h 47m
Deal found 10/1![American Airlines logo]()
$278
Last-minute American Airlines flights from USA to Des MoinesDiscover last-minute American Airlines flight deals from USA to Des Moines. Data last updated October 4, 2026 and is based on user searches.
Discover last-minute American Airlines flight deals from USA to Des Moines. Data last updated October 4, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2210:40 pm -
Nonstop1h 34m
Mon 10/267:31 pm -
Nonstop1h 38m
Deal found 9/30![American Airlines logo]()
$237
This American Airlines deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/217:20 am -
Nonstop1h 35m
Sun 11/229:25 am -
Nonstop1h 49m
Deal found 10/3![American Airlines logo]()
$277
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3010:40 pm -
Nonstop1h 34m
Fri 11/67:23 am -
Nonstop1h 47m
Deal found 10/1![American Airlines logo]()
$278
One-way American Airlines flights to Des MoinesSearch for one-way American Airlines flight options to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 4, 2026.
Search for one-way American Airlines flight options to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 4, 2026.
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/910:53 pm -
Nonstop1h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![American Airlines logo]()
$119
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:09 pm -
1 stop5h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![American Airlines logo]()
$152
This American Airlines deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/32:02 pm -
Nonstop3h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/4![American Airlines logo]()
$158
Flights to Des Moines with American Airlines at a glance
Find detailed information about American Airlines flights from USA to Des Moines. Explore the options provided by American Airlines to plan your journey from USA to Des Moines. Data last updated October 4, 2026.
Cheapflights Insights
Find cheap American Airlines flights to Des Moines
US0-DSM
ORD-DSM
DEN-DSM
LAX-DSM
How long is the flight to Des Moines with American Airlines?
On average, American Airlines flights from the United States to Des Moines take 2 hours 27 minutes. Flights to Des Moines from other popular cities in the United States will vary in length. Below are a few examples of popular routes and their flight times.
American Airlines weekly flight availability to Des Moines
The most flights to Des Moines operated by American Airlines are scheduled on a Sunday (25 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (19 on average).
When is the best time to book a flight to Des Moines with American Airlines?
The best time to book a flight to Des Moines with American Airlines is 39 days before departure. On average, fares are higher if you book 54 days before departure.
When is the cheapest time to fly to Des Moines with American Airlines?
Users looking for the cheapest American Airlines fares to Des Moines should consider flying on Saturday mornings, when prices are typically cheapest. Budget-minded travellers will want to avoid Sunday at noon, when prices are usually at their highest.
FAQs about flights to Des Moines with American Airlines
Reviews of American Airlines
See what Cheapflights users have to say about their American Airlines experience.
Overview
Reviews
American Airlines
10,000 reviews
Overview
Food
6.4
Comfort
7.2
Entertainment
6.8
Boarding
7.4
Crew
7.9
Recent reviews
10.0
|Sep 2026It was a good experience fast and comfy
8.0
|Sep 2026More organized boarding, actual entertainment screens lol
10.0
|Aug 2026Service Excellent
10.0
|Aug 2026I love everything will fly again thank you 😊
2.0
|Aug 2026Terrible. Will not fly it again. Constant delays. Canceled flight because a pilot didn't show up the AA stated it was weather related. AA is also liars and didn't want to take responsibility or pay. Delayed luggage. Just horrible all the way around. Second time with this. Lost luggage on a previous flight. Back to Delta.
1 out of 3334
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