$153+ Cheap flights from Greenville to Des Moines (GSP - DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/16. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — DSM
Jul 10 — Jul 171
Round-trip
1 adult, Economy
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Cheapest flights from Greenville to Des MoinesExplore the most affordable flight options available from Greenville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 10, 2026.
Explore the most affordable flight options available from Greenville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 10, 2026.
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/196:55 am
GSP
- DSM
1 stop4h 48m
Delta
Sat 8/2211:28 am
DSM
- GSP
1 stop6h 37m
Delta
Deal found 6/9![Delta logo]()
$292
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/103:10 pm
GSP
- DSM
1 stop8h 05m
Multiple Airlines
Thu 7/165:08 pm
DSM
- GSP
2 stops20h 33m
Multiple Airlines
Deal found 6/10![Multiple Airlines logo]()
$296
This United Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/196:30 am
GSP
- DSM
1 stop4h 56m
United Airlines
Sat 8/228:00 am
DSM
- GSP
2 stops10h 05m
United Airlines
Deal found 6/9![United Airlines logo]()
$297
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/191:20 pm
GSP
- DSM
2 stops9h 35m
Southwest
Sat 8/225:30 am
DSM
- GSP
2 stops8h 25m
Southwest
Deal found 6/9![Southwest logo]()
$309
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/185:46 am
GSP
- DSM
1 stop5h 57m
Delta
Fri 8/212:54 pm
DSM
- GSP
1 stop4h 38m
Delta
Deal found 6/9![Delta logo]()
$319
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/181:20 pm
GSP
- DSM
2 stops9h 35m
Southwest
Fri 8/215:40 am
DSM
- GSP
2 stops5h 50m
Southwest
Deal found 6/9![Southwest logo]()
$328
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/315:28 pm
GSP
- DSM
1 stop7h 31m
American Airlines
Tue 8/42:41 pm
DSM
- GSP
1 stop5h 54m
American Airlines
Deal found 6/10![American Airlines logo]()
$336
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:30 am
GSP
- DSM
1 stop4h 56m
United Airlines
Wed 8/126:00 am
DSM
- GSP
1 stop6h 32m
United Airlines
Deal found 6/8![United Airlines logo]()
$345
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/88:52 am
GSP
- DSM
1 stop5h 42m
Delta
Wed 7/225:41 am
DSM
- GSP
1 stop5h 33m
Delta
Deal found 6/9![Delta logo]()
$355
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:05 pm
GSP
- DSM
1 stop6h 24m
Delta
Sun 11/811:04 am
DSM
- GSP
1 stop6h 45m
Delta
Deal found 6/10![Delta logo]()
$363
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/103:10 pm
GSP
- DSM
1 stop8h 05m
Allegiant Air
Thu 7/169:23 am
DSM
- GSP
1 stop21h 07m
Allegiant Air
Deal found 6/10![Allegiant Air logo]()
$364
Best flights from Greenville to Des MoinesDiscover carefully curated flight deals from Greenville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 10, 2026.
Discover carefully curated flight deals from Greenville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 10, 2026.
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/191:20 pm
GSP
- DSM
2 stops9h 35m
Southwest
Sat 8/225:30 am
DSM
- GSP
2 stops8h 25m
Southwest
Deal found 6/9![Southwest logo]()
$309
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/315:28 pm
GSP
- DSM
1 stop7h 31m
American Airlines
Tue 8/42:41 pm
DSM
- GSP
1 stop5h 54m
American Airlines
Deal found 6/10![American Airlines logo]()
$336
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:30 am
GSP
- DSM
1 stop4h 56m
United Airlines
Wed 8/126:00 am
DSM
- GSP
1 stop6h 32m
United Airlines
Deal found 6/8![United Airlines logo]()
$345
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/88:52 am
GSP
- DSM
1 stop5h 42m
Delta
Wed 7/225:41 am
DSM
- GSP
1 stop5h 33m
Delta
Deal found 6/9![Delta logo]()
$355
This United Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1810:33 am
GSP
- DSM
1 stop4h 43m
United Airlines
Wed 8/196:00 am
DSM
- GSP
1 stop6h 32m
United Airlines
Deal found 6/9![United Airlines logo]()
$345
This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/107:30 pm
GSP
- DSM
1 stop5h 39m
American Airlines
Tue 7/211:41 pm
DSM
- GSP
1 stop6h 49m
American Airlines
Deal found 6/6![American Airlines logo]()
$407
This Southwest deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2912:55 pm
GSP
- DSM
2 stops7h 30m
Southwest
Wed 9/26:10 am
DSM
- GSP
2 stops9h 35m
Southwest
Deal found 6/7![Southwest logo]()
$417
This United Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/315:43 pm
GSP
- DSM
1 stop4h 39m
United Airlines
Tue 8/46:00 am
DSM
- GSP
2 stops7h 20m
United Airlines
Deal found 6/9![United Airlines logo]()
$421
Last-minute flights from Greenville to Des MoinesDiscover last-minute flight deals from Greenville to Des Moines. Data last updated June 10, 2026 and is based on user searches.
Discover last-minute flight deals from Greenville to Des Moines. Data last updated June 10, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/1210:26 am
GSP
- DSM
1 stop13h 11m
Multiple Airlines
Sat 6/204:22 pm
DSM
- GSP
1 stop21h 51m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$378
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/158:28 pm
GSP
- DSM
1 stop19h 53m
Multiple Airlines
Sat 6/204:22 pm
DSM
- GSP
1 stop21h 51m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$391
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/258:54 pm
GSP
- DSM
2 stops20h 21m
Allegiant Air
Sun 6/289:27 am
DSM
- GSP
1 stop21h 07m
Allegiant Air
Deal found 6/9![Allegiant Air logo]()
$394
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/263:21 pm
GSP
- DSM
1 stop9h 14m
Allegiant Air
Sun 6/289:27 am
DSM
- GSP
1 stop21h 07m
Allegiant Air
Deal found 6/9![Allegiant Air logo]()
$383
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/58:37 am
GSP
- DSM
2 stops14h 21m
Multiple Airlines
Sat 7/114:59 pm
DSM
- GSP
1 stop13h 36m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$372
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/88:52 am
GSP
- DSM
1 stop5h 42m
Delta
Wed 7/225:41 am
DSM
- GSP
1 stop5h 33m
Delta
Deal found 6/9![Delta logo]()
$355
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/103:10 pm
GSP
- DSM
1 stop8h 05m
Multiple Airlines
Thu 7/165:08 pm
DSM
- GSP
2 stops20h 33m
Multiple Airlines
Deal found 6/10![Multiple Airlines logo]()
$296
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/103:10 pm
GSP
- DSM
1 stop8h 05m
Allegiant Air
Thu 7/169:23 am
DSM
- GSP
1 stop21h 07m
Allegiant Air
Deal found 6/10![Allegiant Air logo]()
$364
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/107:20 pm
GSP
- DSM
1 stop5h 41m
American Airlines
Tue 7/216:33 pm
DSM
- GSP
1 stop4h 25m
American Airlines
Deal found 6/10![American Airlines logo]()
$381
This United Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/286:10 am
GSP
- DSM
1 stop5h 07m
United Airlines
Sat 8/16:00 am
DSM
- GSP
2 stops12h 04m
United Airlines
Deal found 6/9![United Airlines logo]()
$396
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/281:50 pm
GSP
- DSM
2 stops10h 00m
Southwest
Sat 8/15:10 am
DSM
- GSP
2 stops13h 50m
Southwest
Deal found 6/9![Southwest logo]()
$397
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/315:28 pm
GSP
- DSM
1 stop7h 31m
American Airlines
Tue 8/42:41 pm
DSM
- GSP
1 stop5h 54m
American Airlines
Deal found 6/10![American Airlines logo]()
$336
One-way flights from Greenville to Des MoinesSearch for one-way flight options from Greenville to Des Moines. Find affordable one-way fares based on user searches. Data last updated June 10, 2026.
Search for one-way flight options from Greenville to Des Moines. Find affordable one-way fares based on user searches. Data last updated June 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/168:25 am
GSP
- DSM
2 stops33h 15m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$153
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/45:44 am
GSP
- DSM
1 stop6h 01m
Delta
Deal found 6/8![Delta logo]()
$178
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/410:30 am
GSP
- DSM
2 stops7h 38m
United Airlines
Deal found 6/8![United Airlines logo]()
$183
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/163:19 pm
GSP
- DSM
1 stop25h 31m
Allegiant Air
Deal found 6/6![Allegiant Air logo]()
$187
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/243:48 pm
GSP
- DSM
2 stops30h 59m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$193
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/23:19 pm
GSP
- DSM
1 stop25h 31m
Allegiant Air
Deal found 6/9![Allegiant Air logo]()
$202
This Delta deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/78:52 am
GSP
- DSM
1 stop5h 42m
Delta
Deal found 6/7![Delta logo]()
$204
This United Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/710:30 am
GSP
- DSM
2 stops11h 52m
United Airlines
Deal found 6/7![United Airlines logo]()
$209
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/510:03 am
GSP
- DSM
1 stop4h 32m
Delta
Deal found 6/8![Delta logo]()
$214
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/28:37 am
GSP
- DSM
2 stops15h 30m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$217
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/263:21 pm
GSP
- DSM
1 stop9h 14m
Allegiant Air
Deal found 6/9![Allegiant Air logo]()
$229
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/58:37 am
GSP
- DSM
2 stops14h 21m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$242
Find flight deals from Greenville to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $292 (Delta) |
One-way from | $153 (Kiwi.com) |
Popular in | March |
Cheapest in | October |
Average price | $646 |
Cheapflights Fare Finder
Customize your flight search to find flights from Greenville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 10, 2026.
Use the filters below to find and compare flights from Greenville to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GreenvilleDes Moines
GSP - DSM
GSPDSM
Greenville
Wed 8/19
1:20 pm-9:55 pm
2 stops9h 35m
Des Moines
Sat 8/22
5:30 am-2:55 pm
2 stops8h 25m
$309
GreenvilleDes Moines
GSP - DSM
GSPDSM
Greenville
Fri 7/31
5:28 pm-11:59 pm
1 stop7h 31m
Des Moines
Tue 8/4
2:41 pm-9:35 pm
1 stop5h 54m
$336
GreenvilleDes Moines
GSP - DSM
GSPDSM
Greenville
Tue 8/11
6:30 am-10:26 am
1 stop4h 56m
Des Moines
Wed 8/12
6:00 am-1:32 pm
1 stop6h 32m
$345
GreenvilleDes Moines
GSP - DSM
GSPDSM
Greenville
Tue 8/18
10:33 am-2:16 pm
1 stop4h 43m
Des Moines
Wed 8/19
6:00 am-1:32 pm
1 stop6h 32m
$345
Quickest round-trip
GreenvilleDes Moines
GSP - DSM
GSPDSM
Greenville
Wed 7/8
8:52 am-1:34 pm
1 stop5h 42m
Des Moines
Wed 7/22
5:41 am-12:14 pm
1 stop5h 33m
$355
GreenvilleDes Moines
GSP - DSM
GSPDSM
Greenville
Fri 7/10
7:30 pm-12:09 am
1 stop5h 39m
Des Moines
Tue 7/21
1:41 pm-9:30 pm
1 stop6h 49m
$407
GreenvilleDes Moines
GSP - DSM
GSPDSM
Greenville
Sat 8/29
12:55 pm-7:25 pm
2 stops7h 30m
Des Moines
Wed 9/2
6:10 am-4:45 pm
2 stops9h 35m
$417
GreenvilleDes Moines
GSP - DSM
GSPDSM
Greenville
Fri 7/31
5:43 pm-9:22 pm
1 stop4h 39m
Des Moines
Tue 8/4
6:00 am-2:20 pm
2 stops7h 20m
$421
Cheapest one-way
GreenvilleDes Moines
GSP - DSM
GSPDSM
Greenville
Thu 7/16
8:25 am-4:40 pm
2 stops33h 15m
$153
GreenvilleDes Moines
GSP - DSM
GSPDSM
Greenville
Sat 7/4
6:49 am-10:45 am
1 stop4h 56m
$178
Showing 1-10 of 17 resultsSorted by cheapest first
Compare providers for flights from Greenville to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to Des Moines in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Greenville-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greenville-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greenville-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Greenville-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Greenville to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Greenville with our price prediction graph.
GSP-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Greenville to Des Moines
What is the cheapest month to book a flight from Greenville to Des Moines?
Currently, October is the cheapest month in which you can book a flight from Greenville to Des Moines (average of $266). Flying from Greenville to Des Moines in March is currently the most expensive (average of $756). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Greenville to Des Moines?
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated June 10, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Greenville to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Food
7.2
Boarding
8.1
Overall
7.9
Crew
8.5
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Entertainment
7.8
Food
7.2
Boarding
8.1
Overall
7.9
Crew
8.5
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Entertainment
7.8
Food
7.2
Boarding
8.1
Overall
7.9
Crew
8.5
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Entertainment
7.8
Food
7.2
Boarding
8.1
Overall
7.9
Crew
8.5
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Greenville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Ames
Johnston
Clive
Boone
West Des Moines
Ankeny
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Greenville and Des Moines flights
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Top 3 airlines flying from Greenville to Des Moines
Discover the top 3 airlines that operate flights from Greenville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$236 | Average$386 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$266 | Average$443 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$326 | Average$626 | FlexibilityNo cancel fee | On-time69% |