$152+ Cheap flights from Greenville to Des Moines (GSP - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/30. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — DSM
Oct 11 — Oct 181
Round-trip
1 adult, Economy
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Find cheap flights from Greenville to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Greenville to Des Moines
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Cheapest flights from Greenville to Des MoinesExplore the most affordable flight options available from Greenville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2026.
Explore the most affordable flight options available from Greenville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:04 pm -
1 stop27h 04m
Thu 10/298:43 am -
2 stops28h 41m
Deal found 9/11![Multiple Airlines logo]()
$322
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:20 am -
1 stop5h 11m
Mon 10/193:11 pm -
1 stop5h 06m
Deal found 9/8![United Airlines logo]()
$340
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:40 am -
1 stop6h 02m
Sun 11/83:03 pm -
1 stop5h 44m
Deal found 9/10![Delta logo]()
$371
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:24 pm -
1 stop6h 48m
Sun 10/46:00 am -
1 stop8h 07m
Deal found 9/10![American Airlines logo]()
$381
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/204:55 pm -
1 stop7h 09m
Tue 10/279:26 am -
1 stop7h 42m
Deal found 9/11![American Airlines logo]()
$387
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/205:46 pm -
1 stop4h 37m
Tue 10/2711:22 am -
2 stops10h 38m
Deal found 9/11![United Airlines logo]()
$392
This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/201:25 pm -
2 stops9h 35m
Tue 10/277:05 am -
2 stops10h 25m
Deal found 9/11![Southwest logo]()
$397
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:42 pm -
1 stop6h 44m
Sun 11/87:06 am -
1 stop4h 06m
Deal found 9/7![American Airlines logo]()
$402
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:20 am -
1 stop5h 11m
Wed 10/211:24 pm -
1 stop6h 53m
Deal found 9/10![United Airlines logo]()
$405
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:39 am -
1 stop24h 56m
Sun 10/41:37 pm -
1 stop28h 03m
Deal found 9/6![Multiple Airlines logo]()
$407
Best flights from Greenville to Des MoinesDiscover carefully curated flight deals from Greenville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 11, 2026.
Discover carefully curated flight deals from Greenville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 11, 2026.
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:20 am -
1 stop5h 11m
Wed 10/211:24 pm -
1 stop6h 53m
Deal found 9/10![United Airlines logo]()
$405
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/97:00 am -
1 stop4h 42m
Sun 10/115:35 am -
1 stop6h 25m
Deal found 9/7![Delta logo]()
$412
This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:25 am -
2 stops7h 55m
Sat 10/175:50 am -
2 stops10h 10m
Deal found 9/11![Southwest logo]()
$438
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:39 am -
1 stop24h 56m
Sun 10/41:37 pm -
2 stops27h 51m
Deal found 9/10![Multiple Airlines logo]()
$447
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:00 am -
1 stop4h 42m
Sat 10/1711:27 am -
1 stop5h 42m
Deal found 9/11![Delta logo]()
$447
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/510:26 am -
2 stops8h 02m
Sun 11/85:30 am -
1 stop8h 33m
Deal found 9/9![United Airlines logo]()
$456
Last-minute flights from Greenville to Des MoinesDiscover last-minute flight deals from Greenville to Des Moines. Data last updated September 11, 2026 and is based on user searches.
Discover last-minute flight deals from Greenville to Des Moines. Data last updated September 11, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:24 pm -
1 stop6h 48m
Sun 10/46:00 am -
1 stop8h 07m
Deal found 9/10![American Airlines logo]()
$381
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:39 am -
1 stop24h 56m
Sun 10/41:37 pm -
1 stop28h 03m
Deal found 9/6![Multiple Airlines logo]()
$407
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/97:00 am -
1 stop4h 42m
Sun 10/115:35 am -
1 stop6h 25m
Deal found 9/7![Delta logo]()
$412
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:20 am -
1 stop5h 11m
Mon 10/193:11 pm -
1 stop5h 06m
Deal found 9/8![United Airlines logo]()
$340
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/204:55 pm -
1 stop7h 09m
Tue 10/279:26 am -
1 stop7h 42m
Deal found 9/11![American Airlines logo]()
$387
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/205:46 pm -
1 stop4h 37m
Tue 10/2711:22 am -
2 stops10h 38m
Deal found 9/11![United Airlines logo]()
$392
This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/201:25 pm -
2 stops9h 35m
Tue 10/277:05 am -
2 stops10h 25m
Deal found 9/11![Southwest logo]()
$397
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:20 am -
1 stop5h 11m
Wed 10/211:24 pm -
1 stop6h 53m
Deal found 9/10![United Airlines logo]()
$405
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:04 pm -
1 stop27h 04m
Thu 10/298:43 am -
2 stops28h 41m
Deal found 9/11![Multiple Airlines logo]()
$322
One-way flights from Greenville to Des MoinesSearch for one-way flight options from Greenville to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 11, 2026.
Search for one-way flight options from Greenville to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 11, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/308:24 pm -
2 stops13h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Multiple Airlines logo]()
$152
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:59 pm -
1 stop27h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Multiple Airlines logo]()
$155
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:20 am -
1 stop7h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![United Airlines logo]()
$163
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/238:28 pm -
1 stop4h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![American Airlines logo]()
$194
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:00 am -
2 stops9h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![United Airlines logo]()
$199
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2312:45 pm -
2 stops11h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Southwest logo]()
$260
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/233:13 pm -
3 stops32h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Allegiant Air logo]()
$398
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/214:49 pm -
1 stop7h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![American Airlines logo]()
$424
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/216:25 pm -
1 stop5h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Delta logo]()
$490
Find flight deals from Greenville to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $322 (Kiwi.com) |
One-way from | $152 (Kiwi.com) |
Popular in | March |
Cheapest in | September |
Average price | $338 |
Cheapflights Fare Finder
Customize your flight search to find flights from Greenville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 11, 2026.
Use the filters below to find and compare flights from Greenville to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GreenvilleDes Moines
GSP Greenville - DSM Des Moines
GSPDSM
Greenville
Wed 9/30
8:24 pm-9:02 am
2 stops13h 38m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$152
GreenvilleDes Moines
GSP Greenville - DSM Des Moines
GSPDSM
Greenville
Wed 9/30
6:32 am-12:04 pm
1 stop6h 32m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$163
GreenvilleDes Moines
GSP Greenville - DSM Des Moines
GSPDSM
Greenville
Wed 9/30
6:20 am-12:34 pm
1 stop7h 14m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$163
Quickest round-trip
GreenvilleDes Moines
GSP Greenville - DSM Des Moines
GSPDSM
Greenville
Wed 12/23
8:28 pm-11:58 pm
1 stop4h 30m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$194
GreenvilleDes Moines
GSP Greenville - DSM Des Moines
GSPDSM
Greenville
Thu 10/1
6:00 am-2:15 pm
2 stops9h 15m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$199
GreenvilleDes Moines
GSP Greenville - DSM Des Moines
GSPDSM
Greenville
Wed 12/23
12:45 pm-11:30 pm
2 stops11h 45m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$260
GreenvilleDes Moines
GSP Greenville - DSM Des Moines
GSPDSM
Greenville
Tue 10/20
6:20 am-10:31 am
1 stop5h 11m
Des Moines
Wed 10/21
1:24 pm-9:17 pm
1 stop6h 53m
$405
GreenvilleDes Moines
GSP Greenville - DSM Des Moines
GSPDSM
Greenville
Fri 10/9
7:00 am-10:42 am
1 stop4h 42m
Des Moines
Sun 10/11
5:35 am-1:00 pm
1 stop6h 25m
$412
GreenvilleDes Moines
GSP Greenville - DSM Des Moines
GSPDSM
Greenville
Mon 9/21
4:49 pm-11:41 pm
1 stop7h 52m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$424
GreenvilleDes Moines
GSP Greenville - DSM Des Moines
GSPDSM
Greenville
Thu 10/8
6:25 am-1:20 pm
2 stops7h 55m
Des Moines
Sat 10/17
5:50 am-5:00 pm
2 stops10h 10m
$438
Showing 1-10 of 14 resultsSorted by cheapest first
Compare providers for flights from Greenville to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to Des Moines in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Greenville-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greenville-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greenville-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Greenville-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Greenville to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Greenville with our price prediction graph.
GSP-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Greenville to Des Moines
What is the cheapest month to book a flight from Greenville to Des Moines?
Currently, September is the cheapest month in which you can book a flight from Greenville to Des Moines (average of $338). Flying from Greenville to Des Moines in March is currently the most expensive (average of $817). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Greenville to Des Moines?
Airfare is typical for this route at the moment.
Greenville to Des Moines flights typically cost between $280 and $637 in October.The cheapest round-trip price found within the last 5 days was $322 on Multiple Airlines (Oct 22-Oct 29).
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated September 11, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Greenville to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Comfort
7.8
Boarding
8.1
Food
7.2
Overall
7.8
Crew
8.5
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Entertainment
7.8
Comfort
7.8
Boarding
8.1
Food
7.2
Overall
7.8
Crew
8.5
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Entertainment
7.8
Comfort
7.8
Boarding
8.1
Food
7.2
Overall
7.8
Crew
8.5
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Entertainment
7.8
Comfort
7.8
Boarding
8.1
Food
7.2
Overall
7.8
Crew
8.5
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
Find useful and relevant information for your journey from Greenville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
Ames
Johnston
Boone
Norwalk
West Des Moines
Ankeny
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Other flights to Des Moines
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Greenville and Des Moines flights
Browse other Greenville and Des Moines flight options. Last updated on September 11, 2026.
Other flights from Greenville
Browse through other flights departing from Greenville. Flights are based on user searches made on Cheapflights and were last updated on September 11, 2026.
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Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Greenville to Des Moines
Discover the top 3 airlines that operate flights from Greenville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$280 | Average$390 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$286 | Average$401 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$311 | Average$456 | FlexibilityNo cancel fee | On-time71% |