$141+ Cheap flights from Greenville to Des Moines (GSP - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/25. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — DSM
Nov 28 — Dec 51
Round-trip
1 adult, Economy
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Find cheap flights from Greenville to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Greenville to Des Moines
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Cheapest flights from Greenville to Des MoinesExplore the most affordable flight options available from Greenville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2026.
Explore the most affordable flight options available from Greenville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2026.
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/25:40 am -
1 stop6h 13m
Tue 12/810:30 am -
1 stop7h 00m
Deal found 10/28![Delta logo]()
$281
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/25:34 pm -
1 stop4h 51m
Tue 12/811:27 am -
2 stops11h 13m
Deal found 10/28![United Airlines logo]()
$286
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/22:50 pm -
2 stops8h 15m
Tue 12/87:00 am -
2 stops10h 10m
Deal found 10/28![Southwest logo]()
$291
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/248:35 pm -
1 stop4h 51m
Tue 12/13:25 pm -
1 stop5h 38m
Deal found 10/27![American Airlines logo]()
$325
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:37 pm -
1 stop5h 18m
Wed 12/28:00 am -
2 stops10h 13m
Deal found 10/28![United Airlines logo]()
$326
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/214:46 pm -
1 stop6h 49m
Fri 11/275:30 am -
1 stop6h 45m
Deal found 10/27![Delta logo]()
$380
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:45 am -
2 stops9h 20m
Wed 12/26:00 am -
2 stops11h 10m
Deal found 10/28![Southwest logo]()
$381
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:40 am -
2 stops9h 46m
Tue 12/13:20 pm -
1 stop4h 39m
Deal found 10/27![United Airlines logo]()
$394
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:45 am -
2 stops9h 20m
Tue 12/16:00 am -
2 stops11h 10m
Deal found 10/27![Southwest logo]()
$403
This Delta deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:00 am -
1 stop4h 44m
Mon 11/306:52 pm -
1 stop4h 01m
Deal found 10/24![Delta logo]()
$428
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:27 pm -
1 stop6h 52m
Sat 11/283:20 pm -
1 stop8h 39m
Deal found 10/28![American Airlines logo]()
$459
Best flights from Greenville to Des MoinesDiscover carefully curated flight deals from Greenville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 29, 2026.
Discover carefully curated flight deals from Greenville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 29, 2026.
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/95:34 pm -
1 stop4h 51m
Sat 12/126:15 am -
2 stops11h 58m
Deal found 10/27![United Airlines logo]()
$286
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/92:50 pm -
2 stops8h 15m
Sat 12/127:00 am -
2 stops10h 10m
Deal found 10/27![Southwest logo]()
$291
This Delta deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:00 am -
1 stop4h 44m
Mon 11/306:52 pm -
1 stop4h 01m
Deal found 10/24![Delta logo]()
$428
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:27 pm -
1 stop6h 52m
Sat 11/283:20 pm -
1 stop8h 39m
Deal found 10/28![American Airlines logo]()
$459
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/1212:50 pm -
2 stops11h 15m
Tue 2/166:55 am -
2 stops10h 20m
Deal found 10/28![Southwest logo]()
$387
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/214:46 pm -
1 stop6h 49m
Fri 11/275:30 am -
1 stop6h 45m
Deal found 10/28![Delta logo]()
$440
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:45 am -
2 stops9h 20m
Tue 12/16:00 am -
2 stops11h 10m
Deal found 10/27![Southwest logo]()
$403
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:52 pm -
1 stop7h 34m
Fri 11/277:24 pm -
1 stop14h 43m
Deal found 10/26![American Airlines logo]()
$561
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:10 pm -
1 stop6h 25m
Sun 11/295:30 am -
1 stop4h 37m
Deal found 10/26![Delta logo]()
$569
Last-minute flights from Greenville to Des MoinesDiscover last-minute flight deals from Greenville to Des Moines. Data last updated October 29, 2026 and is based on user searches.
Discover last-minute flight deals from Greenville to Des Moines. Data last updated October 29, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/214:46 pm -
1 stop6h 49m
Fri 11/275:30 am -
1 stop6h 45m
Deal found 10/27![Delta logo]()
$380
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:27 pm -
1 stop6h 52m
Sat 11/283:20 pm -
1 stop8h 39m
Deal found 10/28![American Airlines logo]()
$459
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:52 pm -
1 stop7h 34m
Fri 11/277:24 pm -
1 stop14h 43m
Deal found 10/27![American Airlines logo]()
$514
This Delta deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:00 am -
1 stop4h 44m
Mon 11/306:52 pm -
1 stop4h 01m
Deal found 10/24![Delta logo]()
$428
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/248:35 pm -
1 stop4h 51m
Tue 12/13:25 pm -
1 stop5h 38m
Deal found 10/27![American Airlines logo]()
$325
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:40 am -
2 stops9h 46m
Tue 12/13:20 pm -
1 stop4h 39m
Deal found 10/27![United Airlines logo]()
$394
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:45 am -
2 stops9h 20m
Tue 12/16:00 am -
2 stops11h 10m
Deal found 10/27![Southwest logo]()
$403
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/258:35 pm -
1 stop4h 51m
Wed 12/211:09 am -
1 stop4h 36m
Deal found 10/28![American Airlines logo]()
$281
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:37 pm -
1 stop5h 18m
Wed 12/28:00 am -
2 stops10h 13m
Deal found 10/28![United Airlines logo]()
$326
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:45 am -
2 stops9h 20m
Wed 12/26:00 am -
2 stops11h 10m
Deal found 10/28![Southwest logo]()
$381
One-way flights from Greenville to Des MoinesSearch for one-way flight options from Greenville to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 29, 2026.
Search for one-way flight options from Greenville to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 29, 2026.
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:27 pm -
1 stop6h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![American Airlines logo]()
$141
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/248:35 pm -
1 stop4h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![American Airlines logo]()
$185
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:45 am -
2 stops9h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Southwest logo]()
$230
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:05 pm -
3 stops27h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Multiple Airlines logo]()
$289
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/249:04 am -
3 stops28h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Multiple Airlines logo]()
$348
Find flight deals from Greenville to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $281 (Delta) |
One-way from | $141 (American Airlines) |
Popular in | March |
Cheapest in | September |
Average price | $379 |
Cheapflights Fare Finder
Customize your flight search to find flights from Greenville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 29, 2026.
Use the filters below to find and compare flights from Greenville to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GreenvilleDes Moines
GSP Greenville - DSM Des Moines
GSPDSM
Greenville
Tue 11/24
6:45 am-3:05 pm
2 stops9h 20m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$230
GreenvilleDes Moines
GSP Greenville - DSM Des Moines
GSPDSM
Greenville
Wed 11/25
5:05 pm-1:45 pm
2 stops45h 40m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$230
GreenvilleDes Moines
GSP Greenville - DSM Des Moines
GSPDSM
Greenville
Wed 12/9
5:34 pm-9:25 pm
1 stop4h 51m
Des Moines
Sat 12/12
6:15 am-7:13 pm
2 stops11h 58m
$286
GreenvilleDes Moines
GSP Greenville - DSM Des Moines
GSPDSM
Greenville
Wed 12/9
2:50 pm-10:05 pm
2 stops8h 15m
Des Moines
Sat 12/12
7:00 am-6:10 pm
2 stops10h 10m
$291
GreenvilleDes Moines
GSP Greenville - DSM Des Moines
GSPDSM
Greenville
Tue 11/24
9:04 am-12:36 pm
3 stops28h 32m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$348
GreenvilleDes Moines
GSP Greenville - DSM Des Moines
GSPDSM
Greenville
Fri 2/12
12:50 pm-11:05 pm
2 stops11h 15m
Des Moines
Tue 2/16
6:55 am-6:15 pm
2 stops10h 20m
$387
GreenvilleDes Moines
GSP Greenville - DSM Des Moines
GSPDSM
Greenville
Tue 11/24
6:45 am-3:05 pm
2 stops9h 20m
Des Moines
Tue 12/1
6:00 am-6:10 pm
2 stops11h 10m
$403
Quickest round-trip
GreenvilleDes Moines
GSP Greenville - DSM Des Moines
GSPDSM
Greenville
Mon 11/23
7:00 am-10:44 am
1 stop4h 44m
Des Moines
Mon 11/30
6:52 pm-11:53 pm
1 stop4h 01m
$428
GreenvilleDes Moines
GSP Greenville - DSM Des Moines
GSPDSM
Greenville
Sat 11/21
4:46 pm-10:35 pm
1 stop6h 49m
Des Moines
Fri 11/27
5:30 am-1:15 pm
1 stop6h 45m
$440
GreenvilleDes Moines
GSP Greenville - DSM Des Moines
GSPDSM
Greenville
Sat 11/21
6:27 pm-12:19 am
1 stop6h 52m
Des Moines
Sat 11/28
3:20 pm-12:59 am
1 stop8h 39m
$459
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from Greenville to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to Des Moines in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Greenville-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greenville-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greenville-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Greenville-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Greenville to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Greenville with our price prediction graph.
GSP-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Greenville to Des Moines
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated October 29, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Greenville to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Entertainment
7.8
Food
7.2
Boarding
8.1
Overall
7.8
Crew
8.5
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Comfort
7.8
Entertainment
7.8
Food
7.2
Boarding
8.1
Overall
7.8
Crew
8.5
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Comfort
7.8
Entertainment
7.8
Food
7.2
Boarding
8.1
Overall
7.8
Crew
8.5
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Comfort
7.8
Entertainment
7.8
Food
7.2
Boarding
8.1
Overall
7.8
Crew
8.5
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Related info for your journey
Find useful and relevant information for your journey from Greenville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
West Des Moines
Ames
Johnston
Boone
Norwalk
Ankeny
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Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 29, 2026.
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Greenville and Des Moines flights
Browse other Greenville and Des Moines flight options. Last updated on October 29, 2026.
Other flights from Greenville
Browse through other flights departing from Greenville. Flights are based on user searches made on Cheapflights and were last updated on October 29, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Greenville to Des Moines
Discover the top 3 airlines that operate flights from Greenville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$280 | Average$390 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$316 | Average$456 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$328 | Average$401 | FlexibilityNo cancel fee | On-timeN/A |