$168+ Cheap flights from Greenville to Des Moines (GSP - DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/1. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — DSM
May 30 — Jun 61
Round-trip
1 adult, Economy
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Find cheap flights from Greenville to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Greenville to Des Moines
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Cheapest flights from Greenville to Des MoinesExplore the most affordable flight options available from Greenville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2026.
Explore the most affordable flight options available from Greenville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2026.
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:40 am
GSP
- DSM
1 stop6h 28m
Delta
Sun 5/246:15 am
DSM
- GSP
1 stop4h 40m
Delta
Deal found 4/29![Delta logo]()
$371
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/168:37 am
GSP
- DSM
2 stops15h 30m
Multiple Airlines
Mon 7/203:52 pm
DSM
- GSP
1 stop22h 14m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$372
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:40 am
GSP
- DSM
1 stop6h 28m
Delta
Mon 5/256:41 pm
DSM
- GSP
1 stop4h 02m
Delta
Deal found 4/27![Delta logo]()
$375
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/202:52 pm
GSP
- DSM
2 stops9h 32m
United Airlines
Sun 5/2411:18 am
DSM
- GSP
1 stop4h 42m
United Airlines
Deal found 4/28![United Airlines logo]()
$376
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/303:19 pm
GSP
- DSM
2 stops23h 31m
Multiple Airlines
Sun 8/29:23 am
DSM
- GSP
1 stop21h 07m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$398
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/226:08 pm
GSP
- DSM
1 stop7h 09m
American Airlines
Mon 5/255:00 am
DSM
- GSP
1 stop5h 04m
American Airlines
Deal found 4/29![American Airlines logo]()
$401
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/108:52 am
GSP
- DSM
1 stop5h 42m
Delta
Tue 7/2111:30 am
DSM
- GSP
1 stop6h 40m
Delta
Deal found 4/28![Delta logo]()
$407
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/91:50 pm
GSP
- DSM
2 stops9h 55m
Southwest
Thu 6/111:30 pm
DSM
- GSP
2 stops8h 20m
Southwest
Deal found 4/27![Southwest logo]()
$411
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/36:00 am
GSP
- DSM
1 stop5h 27m
United Airlines
Tue 7/76:00 am
DSM
- GSP
2 stops7h 20m
United Airlines
Deal found 4/29![United Airlines logo]()
$412
Best flights from Greenville to Des MoinesDiscover carefully curated flight deals from Greenville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 30, 2026.
Discover carefully curated flight deals from Greenville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 30, 2026.
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:45 pm
GSP
- DSM
1 stop4h 38m
United Airlines
Sun 5/2411:18 am
DSM
- GSP
1 stop4h 42m
United Airlines
Deal found 4/28![United Airlines logo]()
$371
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/303:19 pm
GSP
- DSM
2 stops23h 31m
Multiple Airlines
Sun 8/29:23 am
DSM
- GSP
1 stop21h 07m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$398
This American Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/226:08 pm
GSP
- DSM
1 stop7h 09m
American Airlines
Mon 5/256:02 am
DSM
- GSP
1 stop7h 21m
American Airlines
Deal found 4/26![American Airlines logo]()
$401
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/168:52 am
GSP
- DSM
1 stop5h 42m
Delta
Mon 7/206:37 pm
DSM
- GSP
1 stop4h 17m
Delta
Deal found 4/29![Delta logo]()
$407
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:30 am
GSP
- DSM
1 stop4h 41m
United Airlines
Wed 8/125:00 am
DSM
- GSP
1 stop7h 38m
United Airlines
Deal found 4/29![United Airlines logo]()
$415
Last-minute flights from Greenville to Des MoinesDiscover last-minute flight deals from Greenville to Des Moines. Data last updated April 30, 2026 and is based on user searches.
Discover last-minute flight deals from Greenville to Des Moines. Data last updated April 30, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/94:28 pm
GSP
- DSM
1 stop5h 59m
American Airlines
Tue 5/121:25 pm
DSM
- GSP
1 stop7h 05m
American Airlines
Deal found 4/25![American Airlines logo]()
$487
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/95:40 am
GSP
- DSM
1 stop6h 28m
Delta
Tue 5/126:41 pm
DSM
- GSP
1 stop4h 02m
Delta
Deal found 4/28![Delta logo]()
$567
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/141:50 pm
GSP
- DSM
2 stops10h 15m
Southwest
Mon 5/185:25 am
DSM
- GSP
2 stops11h 25m
Southwest
Deal found 4/29![Southwest logo]()
$553
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:45 pm
GSP
- DSM
1 stop4h 38m
United Airlines
Sun 5/2411:18 am
DSM
- GSP
1 stop4h 42m
United Airlines
Deal found 4/28![United Airlines logo]()
$371
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:40 am
GSP
- DSM
1 stop6h 28m
Delta
Mon 5/256:41 pm
DSM
- GSP
1 stop4h 02m
Delta
Deal found 4/27![Delta logo]()
$375
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/216:25 pm
GSP
- DSM
2 stops5h 40m
Southwest
Sun 5/246:00 am
DSM
- GSP
2 stops10h 15m
Southwest
Deal found 4/30![Southwest logo]()
$473
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/212:18 pm
GSP
- DSM
2 stops24h 13m
Multiple Airlines
Sun 5/249:43 am
DSM
- GSP
1 stop20h 50m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$478
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/222:48 pm
GSP
- DSM
1 stop8h 10m
American Airlines
Mon 5/256:02 am
DSM
- GSP
1 stop7h 21m
American Airlines
Deal found 4/28![American Airlines logo]()
$401
One-way flights from Greenville to Des MoinesSearch for one-way flight options from Greenville to Des Moines. Find affordable one-way fares based on user searches. Data last updated April 30, 2026.
Search for one-way flight options from Greenville to Des Moines. Find affordable one-way fares based on user searches. Data last updated April 30, 2026.
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:29 pm
GSP
- DSM
1 stop6h 46m
American Airlines
Deal found 4/25![American Airlines logo]()
$168
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/11:20 pm
GSP
- DSM
2 stops9h 35m
Southwest
Deal found 4/25![Southwest logo]()
$173
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/179:33 am
GSP
- DSM
1 stop25h 00m
Allegiant Air
Deal found 4/28![Allegiant Air logo]()
$176
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/1112:50 pm
GSP
- DSM
2 stops11h 00m
Southwest
Deal found 4/27![Southwest logo]()
$215
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/53:35 pm
GSP
- DSM
1 stop25h 15m
Allegiant Air
Deal found 4/25![Allegiant Air logo]()
$232
This deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/115:41 pm
GSP
- DSM
1 stop4h 59m
United Airlines
Deal found 4/28![United Airlines logo]()
$244
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/57:00 am
GSP
- DSM
2 stops7h 09m
American Airlines
Deal found 4/25![American Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1711:13 am
GSP
- DSM
3 stops36h 44m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$296
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/111:07 am
GSP
- DSM
3 stops27h 24m
Multiple Airlines
Deal found 4/25![Multiple Airlines logo]()
$310
Find flight deals from Greenville to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $371 (United Airlines) |
One-way from | $168 (American Airlines) |
Popular in | March |
Cheapest in | October |
Average price | $415 |
Cheapflights Fare Finder
Customize your flight search to find flights from Greenville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2026.
Use the filters below to find and compare flights from Greenville to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
GreenvilleDes Moines
GSP - DSM
GSPDSM
Greenville
Wed 5/20
5:45 pm-9:23 pm
1 stop4h 38m
Des Moines
Sun 5/24
11:18 am-5:00 pm
1 stop4h 42m
$371
GreenvilleDes Moines
GSP - DSM
GSPDSM
Greenville
Thu 7/30
3:19 pm-1:50 pm
2 stops23h 31m
Des Moines
Sun 8/2
9:23 am-7:30 am
1 stop21h 07m
$398
GreenvilleDes Moines
GSP - DSM
GSPDSM
Greenville
Fri 5/22
6:08 pm-12:17 am
1 stop7h 09m
Des Moines
Mon 5/25
6:02 am-2:23 pm
1 stop7h 21m
$401
GreenvilleDes Moines
GSP - DSM
GSPDSM
Greenville
Thu 7/16
8:52 am-1:34 pm
1 stop5h 42m
Des Moines
Mon 7/20
6:37 pm-11:54 pm
1 stop4h 17m
$407
GreenvilleDes Moines
GSP - DSM
GSPDSM
Greenville
Tue 8/11
6:30 am-10:11 am
1 stop4h 41m
Des Moines
Wed 8/12
5:00 am-1:38 pm
1 stop7h 38m
$415
Cheapest one-way
GreenvilleDes Moines
GSP - DSM
GSPDSM
Greenville
Tue 9/1
5:29 pm-11:15 pm
1 stop6h 46m
$168
GreenvilleDes Moines
GSP - DSM
GSPDSM
Greenville
Tue 9/1
1:20 pm-9:55 pm
2 stops9h 35m
$173
GreenvilleDes Moines
GSP - DSM
GSPDSM
Greenville
Sun 5/17
9:33 am-9:33 am
1 stop25h 00m
$177
Quickest one-way
GreenvilleDes Moines
GSP - DSM
GSPDSM
Greenville
Sat 7/11
6:00 am-10:45 am
1 stop5h 45m
$204
GreenvilleDes Moines
GSP - DSM
GSPDSM
Greenville
Sat 7/11
12:50 pm-10:50 pm
2 stops11h 00m
$215
Showing 1-10 of 15 resultsSorted by cheapest first
Compare providers for flights from Greenville to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to Des Moines in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Greenville-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greenville-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greenville-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Greenville-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Greenville to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Greenville with our price prediction graph.
GSP-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Greenville to Des Moines
What is the cheapest month to book a flight from Greenville to Des Moines?
Currently, October is the cheapest month in which you can book a flight from Greenville to Des Moines (average of $296). Flying from Greenville to Des Moines in March is currently the most expensive (average of $756). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Greenville to Des Moines?
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated April 30, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Greenville to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Boarding
8.1
Comfort
7.9
Crew
8.5
Food
7.2
Entertainment
7.8
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Boarding
8.1
Comfort
7.9
Crew
8.5
Food
7.2
Entertainment
7.8
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Boarding
8.1
Comfort
7.9
Crew
8.5
Food
7.2
Entertainment
7.8
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Boarding
8.1
Comfort
7.9
Crew
8.5
Food
7.2
Entertainment
7.8
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Greenville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Johnston
Ames
Clive
Boone
West Des Moines
Ankeny
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Greenville and Des Moines flights
Browse other Greenville and Des Moines flight options. Last updated on April 30, 2026.
Other flights from Greenville
Browse through other flights departing from Greenville. Flights are based on user searches made on Cheapflights and were last updated on April 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Greenville to Des Moines
Discover the top 3 airlines that operate flights from Greenville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$216 | Average$347 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$216 | Average$379 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$326 | Average$571 | FlexibilityNo cancel fee | On-time69% |