$72+ Cheap flights from Des Moines to Jacksonville (DSM - JAX)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/21. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — JAX
May 30 — Jun 61
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Jacksonville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Des Moines to Jacksonville are usually found in October or August, booked 49 days in advance, depart on a Monday or Tuesday and return on a Tuesday
Cheap flight deals from Des Moines to Jacksonville
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Cheapest flights from Des Moines to JacksonvilleExplore the most affordable flight options available from Des Moines to Jacksonville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2026.
Explore the most affordable flight options available from Des Moines to Jacksonville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/214:01 pm
DSM
- JAX
Nonstop2h 29m
Allegiant Air
Thu 6/259:21 pm
JAX
- DSM
Nonstop2h 37m
Allegiant Air
Deal found 4/29![Allegiant Air logo]()
$72
This Booking.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/74:01 pm
DSM
- JAX
Nonstop2h 29m
Allegiant Air
Thu 6/189:21 pm
JAX
- DSM
Nonstop2h 37m
Allegiant Air
Deal found 4/26![Allegiant Air logo]()
$88
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/185:02 pm
DSM
- JAX
Nonstop2h 29m
Allegiant Air
Sun 6/218:20 pm
JAX
- DSM
Nonstop2h 37m
Allegiant Air
Deal found 4/28![Allegiant Air logo]()
$114
This Mytrip deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/235:08 pm
DSM
- JAX
Nonstop2h 34m
Allegiant Air
Thu 7/309:32 pm
JAX
- DSM
Nonstop2h 35m
Allegiant Air
Deal found 4/28![Allegiant Air logo]()
$168
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/75:02 pm
DSM
- JAX
2 stops23h 33m
Multiple Airlines
Thu 6/189:21 pm
JAX
- DSM
Nonstop2h 37m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$203
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/214:01 pm
DSM
- JAX
Nonstop2h 29m
Multiple Airlines
Thu 6/253:59 pm
JAX
- DSM
1 stop6h 48m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/185:02 pm
DSM
- JAX
Nonstop2h 29m
Multiple Airlines
Sun 6/216:28 pm
JAX
- DSM
2 stops24h 26m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$241
Best flights from Des Moines to JacksonvilleDiscover carefully curated flight deals from Des Moines to Jacksonville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 30, 2026.
Discover carefully curated flight deals from Des Moines to Jacksonville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 30, 2026.
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:27 am
DSM
- JAX
1 stop5h 18m
Delta
Sat 5/307:05 am
JAX
- DSM
1 stop5h 14m
Delta
Deal found 4/28![Delta logo]()
$405
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/144:20 pm
DSM
- JAX
1 stop4h 45m
Southwest
Tue 5/197:20 am
JAX
- DSM
1 stop5h 05m
Southwest
Deal found 4/28![Southwest logo]()
$429
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/305:41 am
DSM
- JAX
1 stop4h 02m
Delta
Tue 8/47:00 am
JAX
- DSM
1 stop4h 45m
Delta
Deal found 4/28![Delta logo]()
$427
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/265:10 am
DSM
- JAX
2 stops6h 25m
Southwest
Tue 6/3011:05 am
JAX
- DSM
2 stops12h 40m
Southwest
Deal found 4/26![Southwest logo]()
$453
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/282:25 pm
DSM
- JAX
1 stop5h 47m
Delta
Tue 8/46:58 pm
JAX
- DSM
1 stop4h 31m
Delta
Deal found 4/26![Delta logo]()
$427
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/154:20 pm
DSM
- JAX
1 stop4h 45m
Southwest
Sun 5/177:40 am
JAX
- DSM
1 stop4h 45m
Southwest
Deal found 4/25![Southwest logo]()
$477
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:40 am
DSM
- JAX
1 stop8h 30m
Southwest
Tue 5/121:50 pm
JAX
- DSM
2 stops8h 25m
Southwest
Deal found 4/25![Southwest logo]()
$512
Last-minute flights from Des Moines to JacksonvilleDiscover last-minute flight deals from Des Moines to Jacksonville. Data last updated April 30, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Jacksonville. Data last updated April 30, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:00 am
DSM
- JAX
1 stop6h 42m
American Airlines
Thu 5/216:30 am
JAX
- DSM
1 stop7h 22m
American Airlines
Deal found 4/28![American Airlines logo]()
$378
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:27 am
DSM
- JAX
1 stop5h 18m
Delta
Sat 5/307:05 am
JAX
- DSM
1 stop5h 14m
Delta
Deal found 4/28![Delta logo]()
$405
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/231:48 pm
DSM
- JAX
2 stops9h 16m
American Airlines
Sat 5/306:05 pm
JAX
- DSM
1 stop7h 12m
American Airlines
Deal found 4/29![American Airlines logo]()
$410
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:30 am
DSM
- JAX
2 stops6h 45m
Southwest
Sat 5/305:10 am
JAX
- DSM
1 stop9h 10m
Southwest
Deal found 4/29![Southwest logo]()
$407
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:33 pm
DSM
- JAX
1 stop6h 54m
Delta
Wed 6/311:40 am
JAX
- DSM
1 stop6h 08m
Delta
Deal found 4/27![Delta logo]()
$351
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/278:43 am
DSM
- JAX
2 stops7h 31m
American Airlines
Wed 6/34:35 pm
JAX
- DSM
1 stop6h 23m
American Airlines
Deal found 4/28![American Airlines logo]()
$356
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:02 am
DSM
- JAX
1 stop6h 05m
American Airlines
Tue 6/26:20 am
JAX
- DSM
1 stop7h 32m
American Airlines
Deal found 4/27![American Airlines logo]()
$389
One-way flights from Des Moines to JacksonvilleSearch for one-way flight options from Des Moines to Jacksonville. Find affordable one-way fares based on user searches. Data last updated April 30, 2026.
Search for one-way flight options from Des Moines to Jacksonville. Find affordable one-way fares based on user searches. Data last updated April 30, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
- JAX
2 stops23h 54m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$152
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/255:27 am
DSM
- JAX
1 stop7h 08m
Delta
Deal found 4/24![Delta logo]()
$203
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/1310:30 am
DSM
- JAX
2 stops31h 05m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$220
This Southwest deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/255:25 am
DSM
- JAX
2 stops10h 30m
Southwest
Deal found 4/24![Southwest logo]()
$225
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/259:59 pm
DSM
- JAX
3 stops42h 36m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:33 pm
DSM
- JAX
2 stops42h 44m
Allegiant Air
Deal found 4/29![Allegiant Air logo]()
$253
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/112:33 pm
DSM
- JAX
1 stop5h 03m
Delta
Deal found 4/26![Delta logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:48 pm
DSM
- JAX
3 stops45h 47m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$257
This American Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:00 am
DSM
- JAX
2 stops6h 45m
American Airlines
Deal found 4/26![American Airlines logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:48 pm
DSM
- JAX
3 stops46h 47m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$264
Find flight deals from Des Moines to Jacksonville
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Jacksonville (JAX). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $72 (Kiwi.com) |
Popular in | March |
Cheapest in | October |
Average price | $388 |
Good round-trip deal | $88 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Jacksonville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2026.
Use the filters below to find and compare flights from Des Moines to Jacksonville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesJacksonville
DSM - JAX
DSMJAX
Des Moines
Sat 5/23
5:27 am-11:45 am
1 stop5h 18m
Jacksonville
Sat 5/30
7:05 am-11:19 am
1 stop5h 14m
$405
Quickest round-trip
Des MoinesJacksonville
DSM - JAX
DSMJAX
Des Moines
Thu 7/30
5:41 am-10:43 am
1 stop4h 02m
Jacksonville
Tue 8/4
7:00 am-10:45 am
1 stop4h 45m
$427
Des MoinesJacksonville
DSM - JAX
DSMJAX
Des Moines
Tue 7/28
2:25 pm-9:12 pm
1 stop5h 47m
Jacksonville
Tue 8/4
6:58 pm-10:29 pm
1 stop4h 31m
$427
Des MoinesJacksonville
DSM - JAX
DSMJAX
Des Moines
Thu 5/14
4:20 pm-10:05 pm
1 stop4h 45m
Jacksonville
Tue 5/19
7:20 am-11:25 am
1 stop5h 05m
$429
Des MoinesJacksonville
DSM - JAX
DSMJAX
Des Moines
Fri 6/26
5:10 am-12:35 pm
2 stops6h 25m
Jacksonville
Tue 6/30
11:05 am-10:45 pm
2 stops12h 40m
$453
Des MoinesJacksonville
DSM - JAX
DSMJAX
Des Moines
Fri 5/15
4:20 pm-10:05 pm
1 stop4h 45m
Jacksonville
Sun 5/17
7:40 am-11:25 am
1 stop4h 45m
$477
Des MoinesJacksonville
DSM - JAX
DSMJAX
Des Moines
Sat 5/9
6:40 am-4:10 pm
1 stop8h 30m
Jacksonville
Tue 5/12
1:50 pm-9:15 pm
2 stops8h 25m
$512
Cheapest one-way
Des MoinesJacksonville
DSM - JAX
DSMJAX
Des Moines
Thu 5/28
4:41 pm-8:50 pm
1 stop27h 09m
$189
Des MoinesJacksonville
DSM - JAX
DSMJAX
Des Moines
Wed 5/13
10:30 am-6:35 pm
2 stops31h 05m
$220
Des MoinesJacksonville
DSM - JAX
DSMJAX
Des Moines
Mon 5/25
5:25 am-4:55 pm
2 stops10h 30m
$225
Showing 1-10 of 15 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Jacksonville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Jacksonville in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Jacksonville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Jacksonville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Jacksonville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Jacksonville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Jacksonville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Jacksonville
Have a flexible travel schedule? Discover the best time to fly to Jacksonville from Des Moines with our price prediction graph.
DSM-JAX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Jacksonville
Prices
More
How far ahead should I book a flight from Des Moines to Jacksonville?
The price you pay for your flight from Des Moines to Jacksonville may vary depending on when you book. For the best chance of a lower fare, look to book 48 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Des Moines to Jacksonville?
Currently, October is the cheapest month in which you can book a flight from Des Moines to Jacksonville (average of $90). Flying from Des Moines to Jacksonville in March is currently the most expensive (average of $455). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Jacksonville?
What’s the top layover airport for flights from Des Moines to Jacksonville?
Share of 1-stop round-trip flights from Des Moines to Jacksonville chosen by Cheapflights users in the past 12 months, using the same layover each way.
Dallas (DFW) – chosen by Cheapflights users on 50% of 1-stop itineraries from Des Moines to Jacksonville on Cheapflights.
What’s the cheapest layover airport for flights from Des Moines to Jacksonville?
Average round-trip fare for 1-stop flights from Des Moines to Jacksonville, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Dallas (DFW) is the most affordable 1-stop option, with an average round-trip price of $276.
What’s the fastest layover option from Des Moines to Jacksonville?
Shortest average travel time for 1-stop one-way flights from Des Moines to Jacksonville, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via St. Louis (STL) have the shortest average one-way travel time for 1-stop routes: 4h 00m.
Which airport typically offers the quickest layover for flights from Des Moines to Jacksonville?
Average layover duration for 1-stop one-way flights from Des Moines to Jacksonville, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via St. Louis (STL) offer the fastest connection on this route, with an average layover time of 1h 15m.
Reviews of airlines servicing Jacksonville
Get insights into the airlines that provide service to Jacksonville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Jacksonville. Reviews last updated April 30, 2026.
Read reviews from past customers who have flown Southwest,Delta, andAllegiant Air from Des Moines to Jacksonville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Food
7.0
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Food
7.0
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Food
7.0
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Food
7.0
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Food
7.0
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Jacksonville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Jacksonville?
Book flights to Jacksonville if you plan to visit one of these locationsJacksonville Beach
Orange Park
Fernandina Beach
Kingsland
Waycross
Atlantic Beach
Yulee
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Explore flights to Jacksonville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 30, 2026.
Des Moines and Jacksonville flights
Browse other Des Moines and Jacksonville flight options. Last updated on April 30, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on April 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 4 airlines flying from Des Moines to Jacksonville
Discover the top 4 airlines that operate flights from Des Moines to Jacksonville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$56 | Average$93 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$150 | Average$396 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$180 | Average$388 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$296 | Average$455 | FlexibilityNo cancel fee | On-time63% |