$178+ Cheap flights from Des Moines to Panama City, FL (DSM - ECP)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/28. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — ECP
Jul 15 — Jul 221
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Des Moines to Panama CityExplore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 15, 2026.
Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 15, 2026.
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1711:00 am
DSM
- ECP
1 stop7h 08m
American Airlines
Tue 9/221:32 pm
ECP
- DSM
1 stop6h 19m
American Airlines
Deal found 6/11![American Airlines logo]()
$290
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:44 am
DSM
- ECP
1 stop6h 56m
Delta
Thu 10/16:00 am
ECP
- DSM
1 stop4h 43m
Delta
Deal found 6/11![Delta logo]()
$317
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/62:25 pm
DSM
- ECP
1 stop7h 10m
Southwest
Mon 8/101:30 pm
ECP
- DSM
2 stops8h 40m
Southwest
Deal found 6/11![Southwest logo]()
$323
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/94:14 pm
DSM
- ECP
1 stop4h 53m
American Airlines
Wed 9/167:33 am
ECP
- DSM
1 stop7h 37m
American Airlines
Deal found 6/11![American Airlines logo]()
$333
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:45 pm
DSM
- ECP
1 stop4h 30m
Delta
Tue 9/229:23 am
ECP
- DSM
1 stop4h 27m
Delta
Deal found 6/14![Delta logo]()
$336
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:10 am
DSM
- ECP
2 stops9h 30m
Southwest
Wed 9/1610:30 am
ECP
- DSM
2 stops10h 30m
Southwest
Deal found 6/11![Southwest logo]()
$346
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:10 am
DSM
- ECP
2 stops9h 30m
Southwest
Thu 8/61:30 pm
ECP
- DSM
2 stops8h 40m
Southwest
Deal found 6/11![Southwest logo]()
$347
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:35 am
DSM
- ECP
1 stop6h 51m
Delta
Wed 7/89:12 am
ECP
- DSM
1 stop4h 22m
Delta
Deal found 6/11![Delta logo]()
$355
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:30 am
DSM
- ECP
1 stop4h 25m
Southwest
Sat 10/310:00 am
ECP
- DSM
2 stops9h 40m
Southwest
Deal found 6/14![Southwest logo]()
$360
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/236:37 pm
DSM
- ECP
1 stop5h 00m
Delta
Tue 7/289:12 am
ECP
- DSM
1 stop4h 22m
Delta
Deal found 6/12![Delta logo]()
$362
Best flights from Des Moines to Panama CityDiscover carefully curated flight deals from Des Moines to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 15, 2026.
Discover carefully curated flight deals from Des Moines to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 15, 2026.
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/264:10 pm
DSM
- ECP
1 stop6h 46m
Delta
Sat 10/36:00 am
ECP
- DSM
1 stop4h 43m
Delta
Deal found 6/14![Delta logo]()
$355
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:30 am
DSM
- ECP
2 stops8h 25m
Southwest
Sat 10/35:55 am
ECP
- DSM
2 stops7h 40m
Southwest
Deal found 6/14![Southwest logo]()
$366
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/55:10 pm
DSM
- ECP
1 stop5h 30m
American Airlines
Sat 8/85:48 pm
ECP
- DSM
1 stop5h 22m
American Airlines
Deal found 6/12![American Airlines logo]()
$382
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/236:37 pm
DSM
- ECP
1 stop5h 00m
Delta
Tue 7/289:12 am
ECP
- DSM
1 stop4h 22m
Delta
Deal found 6/14![Delta logo]()
$362
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/102:25 pm
DSM
- ECP
1 stop7h 10m
Southwest
Sun 9/134:00 pm
ECP
- DSM
1 stop6h 35m
Southwest
Deal found 6/12![Southwest logo]()
$381
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:35 am
DSM
- ECP
1 stop5h 15m
Delta
Wed 7/89:12 am
ECP
- DSM
1 stop4h 22m
Delta
Deal found 6/13![Delta logo]()
$368
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/62:25 pm
DSM
- ECP
1 stop7h 10m
Southwest
Mon 8/1011:20 am
ECP
- DSM
1 stop9h 55m
Southwest
Deal found 6/11![Southwest logo]()
$388
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:37 pm
DSM
- ECP
1 stop5h 00m
Delta
Mon 7/275:03 pm
ECP
- DSM
1 stop5h 26m
Delta
Deal found 6/11![Delta logo]()
$381
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/225:20 am
DSM
- ECP
2 stops10h 20m
Southwest
Mon 7/276:10 am
ECP
- DSM
1 stop5h 20m
Southwest
Deal found 6/11![Southwest logo]()
$392
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/94:15 pm
DSM
- ECP
1 stop6h 31m
Delta
Mon 9/141:47 pm
ECP
- DSM
1 stop4h 13m
Delta
Deal found 6/11![Delta logo]()
$407
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/236:37 pm
DSM
- ECP
1 stop5h 00m
Delta
Sun 7/266:00 am
ECP
- DSM
1 stop4h 45m
Delta
Deal found 6/10![Delta logo]()
$407
Last-minute flights from Des Moines to Panama CityDiscover last-minute flight deals from Des Moines to Panama City. Data last updated June 15, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Panama City. Data last updated June 15, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:35 am
DSM
- ECP
1 stop5h 15m
Delta
Wed 7/89:12 am
ECP
- DSM
1 stop4h 22m
Delta
Deal found 6/12![Delta logo]()
$336
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/135:41 am
DSM
- ECP
1 stop6h 50m
Delta
Fri 7/2411:38 am
ECP
- DSM
1 stop6h 14m
Delta
Deal found 6/13![Delta logo]()
$407
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1411:30 am
DSM
- ECP
1 stop4h 42m
Delta
Fri 7/246:00 am
ECP
- DSM
1 stop4h 45m
Delta
Deal found 6/11![Delta logo]()
$381
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:20 am
DSM
- ECP
2 stops8h 30m
Southwest
Fri 7/246:10 am
ECP
- DSM
1 stop5h 20m
Southwest
Deal found 6/11![Southwest logo]()
$386
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/225:20 am
DSM
- ECP
2 stops10h 20m
Southwest
Mon 7/271:25 pm
ECP
- DSM
2 stops10h 10m
Southwest
Deal found 6/11![Southwest logo]()
$397
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/236:37 pm
DSM
- ECP
1 stop5h 00m
Delta
Tue 7/289:12 am
ECP
- DSM
1 stop4h 22m
Delta
Deal found 6/12![Delta logo]()
$362
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/236:10 am
DSM
- ECP
2 stops11h 05m
Southwest
Tue 7/2810:25 am
ECP
- DSM
2 stops12h 25m
Southwest
Deal found 6/11![Southwest logo]()
$402
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/235:10 am
DSM
- ECP
1 stop5h 40m
Southwest
Sun 7/266:05 pm
ECP
- DSM
2 stops5h 45m
Southwest
Deal found 6/10![Southwest logo]()
$412
One-way flights from Des Moines to Panama CitySearch for one-way flight options from Des Moines to Panama City. Find affordable one-way fares based on user searches. Data last updated June 15, 2026.
Search for one-way flight options from Des Moines to Panama City. Find affordable one-way fares based on user searches. Data last updated June 15, 2026.
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/286:37 pm
DSM
- ECP
1 stop5h 00m
Delta
Deal found 6/10![Delta logo]()
$178
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/285:20 am
DSM
- ECP
2 stops8h 30m
Southwest
Deal found 6/10![Southwest logo]()
$183
This deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/288:00 am
DSM
- ECP
1 stop5h 24m
United Airlines
Deal found 6/12![United Airlines logo]()
$244
Find flight deals from Des Moines to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 15, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $290 (American Airlines) |
One-way from | $178 (Delta) |
Popular in | November |
Cheapest in | August |
Average price | $456 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 15, 2026.
Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Sat 9/26
4:10 pm-10:56 pm
1 stop6h 46m
Panama City NW Florida Beaches
Sat 10/3
6:00 am-10:43 am
1 stop4h 43m
$355
Quickest round-trip
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Thu 7/23
6:37 pm-11:37 pm
1 stop5h 00m
Panama City NW Florida Beaches
Tue 7/28
9:12 am-1:34 pm
1 stop4h 22m
$362
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Sat 9/26
5:30 am-1:55 pm
2 stops8h 25m
Panama City NW Florida Beaches
Sat 10/3
5:55 am-1:35 pm
2 stops7h 40m
$366
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Wed 7/1
5:35 am-10:50 am
1 stop5h 15m
Panama City NW Florida Beaches
Wed 7/8
9:12 am-1:34 pm
1 stop4h 22m
$368
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Thu 9/10
2:25 pm-9:35 pm
1 stop7h 10m
Panama City NW Florida Beaches
Sun 9/13
4:00 pm-10:35 pm
1 stop6h 35m
$381
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Wed 7/22
6:37 pm-11:37 pm
1 stop5h 00m
Panama City NW Florida Beaches
Mon 7/27
5:03 pm-10:29 pm
1 stop5h 26m
$381
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Wed 8/5
5:10 pm-10:40 pm
1 stop5h 30m
Panama City NW Florida Beaches
Sat 8/8
5:48 pm-11:10 pm
1 stop5h 22m
$382
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Thu 8/6
2:25 pm-9:35 pm
1 stop7h 10m
Panama City NW Florida Beaches
Mon 8/10
11:20 am-9:15 pm
1 stop9h 55m
$388
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Wed 7/22
5:20 am-3:40 pm
2 stops10h 20m
Panama City NW Florida Beaches
Mon 7/27
6:10 am-11:30 am
1 stop5h 20m
$392
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Wed 9/9
4:15 pm-10:46 pm
1 stop6h 31m
Panama City NW Florida Beaches
Mon 9/14
1:47 pm-6:00 pm
1 stop4h 13m
$407
Showing 1-10 of 14 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Panama City in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Panama City, Florida flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Des Moines with our price prediction graph.
DSM-ECP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Panama City
What is the cheapest month to book a flight from Des Moines to Panama City, Florida?
Currently, August is the cheapest month in which you can book a flight from Des Moines to Panama City, Florida (average of $328). Flying from Des Moines to Panama City, Florida in November is currently the most expensive (average of $528). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Panama City, Florida?
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated June 15, 2026.
Read through reviews of airlines operating flights from Des Moines to Panama City, such as Southwest,Delta, andUnited Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
8.0
Overall
7.9
Entertainment
7.5
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Comfort
8.0
Overall
7.9
Entertainment
7.5
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Comfort
8.0
Overall
7.9
Entertainment
7.5
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Comfort
8.0
Overall
7.9
Entertainment
7.5
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Comfort
8.0
Overall
7.9
Entertainment
7.5
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Panama City?
Book flights to Panama City if you plan to visit one of these locationsMexico Beach
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Des Moines and Panama City flights
Browse other Des Moines and Panama City flight options. Last updated on June 15, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on June 15, 2026.
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Top 4 airlines flying from Des Moines to Panama City
Discover the top 4 airlines that operate flights from Des Moines to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 15, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$239 | Average$460 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$262 | Average$386 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$297 | Average$392 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$342 | Average$503 | FlexibilityNo cancel fee | On-time69% |