What are the cheapest airlines flying from Des Moines to Panama City, Florida round-trip?

Cheapflights users have booked flights from Des Moines to Panama City, Florida round-trip from $259. Other airlines that can offer you cheap pricing are American Airlines, from $291, and Southwest, from $313. Delta is priced at 40% lower than the current average price of a flight leaving 3 months from now.

What is the cheapest day to fly from Des Moines to Panama City, Florida?

Travelers seeking maximum savings on their Des Moines to Panama City, Florida flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Friday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Panama City, Florida ranges from 2.8 - 7.9 inches per month. July is typically the wettest month, when rainfall can reach 7.9 in. May is typically the driest time to visit Panama City, Florida when rainfall is around 2.8 in.

If weather is an important factor for your trip to Panama City, Florida, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 53.6 F).

What are the most popular airlines that fly from Des Moines to Panama City, Florida?

Before booking your flight from Des Moines to Panama City, Florida check out the most popular airlines for this route: American Airlines, Delta or United Airlines.

What is the cheapest day to fly round-trip from Des Moines to Panama City, Florida?

Travelers have found that booking a Monday departure is the best way to save up to 30% on the cost of booking your flights compared to booking on days of the week where this route is of high demand.

How far in advance should I book a flight from Des Moines to Panama City, Florida?

Find a great deal and save up to 56% by booking at least 32 days prior to your desired departure date, rather than waiting until the week of travel. According to our data, there are a number of flights available from Des Moines to Panama City, Florida within the next two weeks, with the cheapest ticket starting at $443.

What is the cheapest month to fly from Des Moines to Panama City, Florida?

Our data shows that September tends to be the cheapest month to fly to Panama City, Florida from Des Moines. Users have commonly found prices around $434 for the month, but tickets can be as low as $272. Due to multiple factors, prepare for potentially higher prices in March.

Can I find deals for flights from Des Moines to Panama City that include hotel bookings?

Yes. In addition to deals on Des Moines to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama City.

Can I find deals for business class flights from Des Moines to Panama City?

Yes. Cheapflights offers flight deals from Des Moines to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$259+ Flights from Des Moines to Panama City, FL

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1. Tell us where you want to go

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Cheapflights Tip: The best prices from Des Moines to Panama City NW Florida Beaches are usually found in September or August, booked 69 days in advance, depart on a Tuesday or Monday and return on a Friday

Cheap flight deals from Des Moines to Panama City

Round-trip from	$259 (Delta)
Popular in	March
Cheapest in	September
Average price	$366

From Des Moines to Panama City NW Florida Beaches

Search Deals

Highest demand for flights based on searches. 12% potential increase in price ($61 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 5% potential price decrease ($21 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in July 2025

Search Deals

Find flight deals from Des Moines to Panama City

Cheapest flights from Des Moines to Panama City
Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julho 2, 2025.

ter 9/306:30 pmDSM - ECP

1 stop4h 33mDelta

sáb 10/46:00 amECP - DSM

1 stop4h 40mDelta

Deal found 7/1

$259

qua 10/17:03 amDSM - ECP

2 stops10h 33mAmerican Airlines

sex 10/3110:43 amECP - DSM

2 stops10h 30mAmerican Airlines

Deal found 7/1

$277

sáb 9/138:35 amDSM - ECP

2 stops10h 35mSouthwest

sáb 9/2010:55 amECP - DSM

2 stops9h 25mSouthwest

Deal found 6/30

$313

sáb 7/196:50 pmDSM - ECP

2 stops15h 06mUnited Airlines

sáb 7/266:30 amECP - DSM

2 stops9h 50mUnited Airlines

Deal found 6/30

$736

qui 7/39:34 amDSM - ECP

1 stop5h 36mAlaska Airlines

sáb 7/51:32 pmECP - DSM

1 stop8h 26mAlaska Airlines

Deal found 6/30

$881

Best flights from Des Moines to Panama City
Discover carefully curated flight deals from Des Moines to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated julho 2, 2025.

ter 9/306:30 pmDSM - ECP

1 stop4h 33mDelta

sáb 10/46:00 amECP - DSM

1 stop4h 40mDelta

Deal found 7/1

$259

sáb 8/169:01 amDSM - ECP

2 stops9h 14mAmerican Airlines

sáb 8/235:30 amECP - DSM

2 stops9h 21mAmerican Airlines

Deal found 7/1

$291

sáb 9/138:35 amDSM - ECP

2 stops10h 35mSouthwest

sáb 9/2010:55 amECP - DSM

2 stops9h 25mSouthwest

Deal found 6/30

$313

sáb 7/196:50 pmDSM - ECP

2 stops15h 06mUnited Airlines

sáb 7/266:30 amECP - DSM

2 stops9h 50mUnited Airlines

Deal found 6/30

$736

Last-minute flights from Des Moines to Panama City
Discover last-minute flight deals from Des Moines to Panama City. Data last updated julho 2, 2025 and is based on user searches.

qui 7/39:34 amDSM - ECP

1 stop5h 36mAlaska Airlines

sáb 7/51:32 pmECP - DSM

1 stop8h 26mAlaska Airlines

Deal found 6/30

$881

ter 7/155:30 amDSM - ECP

1 stop6h 49mDelta

sáb 7/195:05 pmECP - DSM

1 stop5h 28mDelta

Deal found 6/30

$427

sáb 7/196:50 pmDSM - ECP

2 stops15h 06mUnited Airlines

sáb 7/266:30 amECP - DSM

2 stops9h 50mUnited Airlines

Deal found 6/30

$736

sáb 8/166:10 amDSM - ECP

1 stop8h 05mSouthwest

sáb 8/2310:55 amECP - DSM

1 stop4h 05mSouthwest

Deal found 7/1

$281

sáb 8/169:01 amDSM - ECP

2 stops9h 14mAmerican Airlines

sáb 8/235:30 amECP - DSM

2 stops9h 21mAmerican Airlines

Deal found 7/1

$291

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

ter 9/30

6:30 pm-11:03 pm

1 stop4h 33m

Panama City NW Florida Beaches

sáb 10/4

6:00 am-10:40 am

1 stop4h 40m

$259

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

sáb 8/16

9:01 am-6:15 pm

2 stops9h 14m

Panama City NW Florida Beaches

sáb 8/23

5:30 am-2:51 pm

2 stops9h 21m

$291

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

sáb 9/13

8:35 am-7:10 pm

2 stops10h 35m

Panama City NW Florida Beaches

sáb 9/20

10:55 am-8:20 pm

2 stops9h 25m

$313

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

sáb 7/19

6:50 pm-9:56 am

2 stops15h 06m

Panama City NW Florida Beaches

sáb 7/26

6:30 am-4:20 pm

2 stops9h 50m

$736

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/1

Best time to book a flight from Des Moines to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama City

How far ahead should I book a flight from Des Moines to Panama City, Florida?

The best time to book flights from Des Moines to Panama City, Florida is 69 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Des Moines to Panama City, Florida?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Panama City, Florida (average of $346). Flying from Des Moines to Panama City, Florida in March is currently the most expensive (average of $461). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to ECP?

One of the essential ways to save on airfare from Des Moines to Panama City, Florida is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the afternoon could potentially save you up to 6% on airfare.

Reviews of airlines servicing Panama City

Read through reviews of airlines operating flights from Des Moines to Panama City, such as Southwest, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,272 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Southwest

8.0

Very good

4,272 reviews

Southwest

8.0

Very good

4,272 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Delta

8.0

Very good

7,975 reviews

Southwest

8.0

Very good

4,272 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

United Airlines

7.4

Good

8,861 reviews

Southwest

8.0

Very good

4,272 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

American Airlines

7.2

Good

10,000 reviews

Southwest

8.0

Very good

4,272 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

What are the cheapest airlines flying from Des Moines to Panama City, Florida round-trip?
Cheapflights users have booked flights from Des Moines to Panama City, Florida round-trip from $259. Other airlines that can offer you cheap pricing are American Airlines, from $291, and Southwest, from $313. Delta is priced at 40% lower than the current average price of a flight leaving 3 months from now.
Can I find deals for flights from Des Moines to Panama City that include hotel bookings?
Yes. In addition to deals on Des Moines to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama City.
Can I find deals for business class flights from Des Moines to Panama City?
Yes. Cheapflights offers flight deals from Des Moines to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to Panama City, Florida?
Currently, January is the cheapest month in which you can book a flight from Des Moines to Panama City, Florida (average of $346). Flying from Des Moines to Panama City, Florida in March is currently the most expensive (average of $461). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 4 airlines flying from Des Moines to Panama City

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$267	Average$407	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$283	Average$410	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$302	Average$477	FlexibilityNo cancel fee	On-time69%
Southwest	Cheapest$351	Average$426	FlexibilityNo cancel fee	On-time63%

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$259+ Cheap flights from Des Moines to Panama City, FL (DSM - ECP)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/30. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Panama City with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Des Moines to Panama City NW Florida Beaches are usually found in September or August, booked 69 days in advance, depart on a Tuesday or Monday and return on a Friday

Cheap flight deals from Des Moines to Panama City

Round-trip from

Popular in

Cheapest in

Average price

Find flight deals from Des Moines to Panama City

Cheapest flights from Des Moines to Panama CityExplore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julho 2, 2025.

Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julho 2, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.

Best time to book a flight from Des Moines to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama City

How far ahead should I book a flight from Des Moines to Panama City, Florida?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Panama City. Price data was last updated on June 27, 2025.

What is the cheapest month to book a flight from Des Moines to Panama City, Florida?

What is the cheapest time of day to fly from DSM to ECP?

Find hourly flight availability from Des Moines to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated julho 2, 2025.

Reviews of airlines servicing Panama City

Read through reviews of airlines operating flights from Des Moines to Panama City, such as Southwest, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Des Moines to Panama City, Florida round-trip?

Can I find deals for flights from Des Moines to Panama City that include hotel bookings?

How can I find direct flights from Des Moines to Panama City?

Can I find deals for business class flights from Des Moines to Panama City?

What is the cheapest month to book a flight from Des Moines to Panama City, Florida?

Traveling to a place near Des Moines?

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Alternative routes for Des Moines to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from Des Moines to Panama City

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Cheapest flights from Des Moines to Panama City
Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julho 2, 2025.