Panama City

$149+ Cheap flights from Des Moines to Panama City, FL (DSM - ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/22. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — ECP
Feb 18 — Feb 251
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Panama City with Cheapflights

1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”
2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.
3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

The best prices from Des Moines to Panama City NW Florida Beaches are usually found in October or September, booked 33 days in advance, depart on a Tuesday or Monday and return on a Friday

Cheap flight deals from Des Moines to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 13, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$303
(Delta)

One-way from

$149
(Delta)

Popular in

March

Cheapest in

October

Average price

$392
Provider with most accurate pricing for Des Moines-Panama City NW Florida Beaches flight deals.
Provider most trusted by Cheapflights users for Des Moines-Panama City NW Florida Beaches flights.
From Des Moines to Panama City NW Florida Beaches
One-way flight from Des Moines to Panama City NW Florida Beaches
Highest demand for flights based on searches. 12% potential increase in price ($61 potential increase over avg. RT price).
Cheapest flight prices on average. 5% potential price decrease ($23 potential savings vs. average RT price).
Average for round-trip flights in February 2025

Find flight deals from Des Moines to Panama City

Cheapest flights from Des Moines to Panama City
Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 13, 2025.

This Delta deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/66:26 pmDSM - ECP
1 stop4h 37mDelta
Mon 3/106:00 amECP - DSM
1 stop4h 40mDelta
Deal found 2/13$303
This United Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/15:45 amDSM - ECP
2 stops10h 32mUnited Airlines
Wed 4/304:58 pmECP - DSM
1 stop5h 47mUnited Airlines
Deal found 2/13$308
This American Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/15:06 amDSM - ECP
2 stops8h 55mAmerican Airlines
Wed 4/3010:13 amECP - DSM
2 stops8h 48mAmerican Airlines
Deal found 2/13$313
This Southwest deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/65:45 amDSM - ECP
2 stops7h 30mSouthwest
Mon 3/106:25 pmECP - DSM
2 stops5h 30mSouthwest
Deal found 2/13$353

Find flights from Des Moines to Panama City within your budget

Customize your flight search to find flights from Des Moines to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 13, 2025.

Fly from

Des Moines

Fly to

Panama City

Route

Depart

Return

Price

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Thu 3/6

6:26 pm-11:03 pm

1 stop4h 37m

Panama City NW Florida Beaches

Mon 3/10

6:00 am-10:40 am

1 stop4h 40m

$303

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 4/1

5:45 am-4:17 pm

2 stops10h 32m

Panama City NW Florida Beaches

Wed 4/30

4:58 pm-10:45 pm

1 stop5h 47m

$308

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 4/1

5:06 am-2:01 pm

2 stops8h 55m

Panama City NW Florida Beaches

Wed 4/30

10:13 am-7:01 pm

2 stops8h 48m

$313

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Thu 3/6

5:45 am-1:15 pm

2 stops7h 30m

Panama City NW Florida Beaches

Mon 3/10

6:25 pm-11:55 pm

2 stops5h 30m

$353

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Sat 2/22

4:20 pm-11:03 pm

1 stop6h 43m

$149

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Mon 3/17

6:45 pm-12:34 pm

2 stops17h 49m

$273

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Thu 5/22

7:00 am-9:50 pm

2 stops14h 50m

$274

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/13

Compare providers for flights from Des Moines to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Panama City in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Panama City, Florida flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Des Moines to Panama City

Get recent, data-driven insights about flights from Des Moines to Panama City including ideal travel times, pricing trends, and more.

How far ahead should I book a flight from Des Moines to Panama City, Florida?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Panama City. Price data was last updated on February 7, 2025.

The best time to book flights from Des Moines to Panama City, Florida is 33 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Des Moines to Panama City, Florida?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Panama City, Florida (average of $346). Flying from Des Moines to Panama City, Florida in March is currently the most expensive (average of $462). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to ECP?

Find hourly flight availability from Des Moines to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 13, 2025.

One of the essential ways to save on airfare from Des Moines to Panama City, Florida is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the afternoon could potentially save you up to 6% on airfare.

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama City, Florida ranges from 2.8 - 7.9 inches per month. July is typically the wettest month, when rainfall can reach 7.9 in. May is typically the driest time to visit Panama City, Florida when rainfall is around 2.8 in.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama City, Florida, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 53.6 F).

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated February 13, 2025.
To help decide which airline to fly from Des Moines to Panama City, see what other customers have to say about Southwest, Delta and United Airlines. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Entertainment

7.6

Food

7.1

Overall

8.1

Boarding

8.2

Comfort

8.1

Crew

8.7

Reviews

1 / 20

2.0
Mediocre

Steven,Feb 2025

BZN - DEN

Bozeman Airport knows how to deal with snow. I saw many airlines leave with only small delays due to the foot of snow. Our plane was 4 hours delayed. I missed my connection in Denver with a 3.5 hour layover. Because of that, the best you Southwest could do was make me wait more hours, them send me to Chicago Midway, where I had to wait overnight, for 7 more hours until a flight to RSW was available. Nobody at Southwest told me that Midway shuts down after 8pm. Everything was closed. I had no idea. You just dumped me there. I am a 65 year old man and you dumped me in Midway without even a couch to lie on. I was awake 21 hours because of this. No, it was not an act of God. Other airlines were moving passengers out. It was incompetence Shame on you.

Entertainment

7.6

Food

7.1

Overall

8.1

Boarding

8.2

Comfort

8.1

Crew

8.7

Reviews

1 / 20

2.0
Mediocre

Steven,Feb 2025

BZN - DEN

Bozeman Airport knows how to deal with snow. I saw many airlines leave with only small delays due to the foot of snow. Our plane was 4 hours delayed. I missed my connection in Denver with a 3.5 hour layover. Because of that, the best you Southwest could do was make me wait more hours, them send me to Chicago Midway, where I had to wait overnight, for 7 more hours until a flight to RSW was available. Nobody at Southwest told me that Midway shuts down after 8pm. Everything was closed. I had no idea. You just dumped me there. I am a 65 year old man and you dumped me in Midway without even a couch to lie on. I was awake 21 hours because of this. No, it was not an act of God. Other airlines were moving passengers out. It was incompetence Shame on you.

8.0
Very good

Entertainment

7.6

Food

7.1

Overall

8.1

Boarding

8.2

Comfort

8.1

Crew

8.7

Reviews

1 / 20

2.0
Mediocre

Steven,Feb 2025

BZN - DEN

Bozeman Airport knows how to deal with snow. I saw many airlines leave with only small delays due to the foot of snow. Our plane was 4 hours delayed. I missed my connection in Denver with a 3.5 hour layover. Because of that, the best you Southwest could do was make me wait more hours, them send me to Chicago Midway, where I had to wait overnight, for 7 more hours until a flight to RSW was available. Nobody at Southwest told me that Midway shuts down after 8pm. Everything was closed. I had no idea. You just dumped me there. I am a 65 year old man and you dumped me in Midway without even a couch to lie on. I was awake 21 hours because of this. No, it was not an act of God. Other airlines were moving passengers out. It was incompetence Shame on you.

Entertainment

7.6

Food

7.1

Overall

8.1

Boarding

8.2

Comfort

8.1

Crew

8.7

Reviews

1 / 20

2.0
Mediocre

Steven,Feb 2025

BZN - DEN

Bozeman Airport knows how to deal with snow. I saw many airlines leave with only small delays due to the foot of snow. Our plane was 4 hours delayed. I missed my connection in Denver with a 3.5 hour layover. Because of that, the best you Southwest could do was make me wait more hours, them send me to Chicago Midway, where I had to wait overnight, for 7 more hours until a flight to RSW was available. Nobody at Southwest told me that Midway shuts down after 8pm. Everything was closed. I had no idea. You just dumped me there. I am a 65 year old man and you dumped me in Midway without even a couch to lie on. I was awake 21 hours because of this. No, it was not an act of God. Other airlines were moving passengers out. It was incompetence Shame on you.

Entertainment

7.6

Food

7.1

Overall

8.1

Boarding

8.2

Comfort

8.1

Crew

8.7

Reviews

1 / 20

2.0
Mediocre

Steven,Feb 2025

BZN - DEN

Bozeman Airport knows how to deal with snow. I saw many airlines leave with only small delays due to the foot of snow. Our plane was 4 hours delayed. I missed my connection in Denver with a 3.5 hour layover. Because of that, the best you Southwest could do was make me wait more hours, them send me to Chicago Midway, where I had to wait overnight, for 7 more hours until a flight to RSW was available. Nobody at Southwest told me that Midway shuts down after 8pm. Everything was closed. I had no idea. You just dumped me there. I am a 65 year old man and you dumped me in Midway without even a couch to lie on. I was awake 21 hours because of this. No, it was not an act of God. Other airlines were moving passengers out. It was incompetence Shame on you.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What are the cheapest airlines flying from Des Moines to Panama City, Florida round-trip?

    Cheapflights users have booked flights from Des Moines to Panama City, Florida round-trip from $303. Other airlines that can offer you cheap pricing are United Airlines, from $308, and American Airlines, from $313. Delta is priced at 32% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Des Moines to Panama City, Florida one-way?

    One-way options have recently been found by users for as low as $149 on Delta. Other airlines that offer cheap prices include United Airlines from $273 and Southwest from $274 one-way.

  • Can I find deals for flights from Des Moines to Panama City that include hotel bookings?

    Yes. In addition to deals on Des Moines to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama City.

  • Can I find deals for business class flights from Des Moines to Panama City?

    Yes. Cheapflights offers flight deals from Des Moines to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Panama City, Florida?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Panama City, Florida (average of $346). Flying from Des Moines to Panama City, Florida in March is currently the most expensive (average of $462). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Mexico Beach

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from Des Moines to Panama City

Discover the top 4 airlines that operate flights from Des Moines to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$286Average$399FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$292Average$495FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$297Average$421FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$312Average$467FlexibilityNo cancel feeOn-time69%
100% Free
Cheapflights is completely free to use, so you can start saving the moment you arrive.
Book with Flexibility
Our users can plan ahead with confidence and find flights with no change fees
Travel Smart
Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.