$125+ Cheap flights from Panama City, FL to St. Louis (ECP - STL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/24. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — STL
Nov 24 — Dec 11
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to St. Louis
Cheapest
Best
Last-minute
One-way
Cheapest flights from Panama City to St. LouisExplore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/194:55 pm -
1 stop5h 30m
Thu 11/268:30 am -
1 stop7h 48m
Deal found 10/22![United Airlines logo]()
$249
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/204:55 pm -
1 stop5h 31m
Fri 11/278:30 am -
1 stop5h 58m
Deal found 10/23![United Airlines logo]()
$265
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/116:00 am -
1 stop5h 29m
Sun 12/135:31 pm -
1 stop5h 46m
Deal found 10/20![Delta logo]()
$269
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/115:05 pm -
1 stop7h 30m
Sun 12/131:25 pm -
2 stops7h 10m
Deal found 10/20![Southwest logo]()
$274
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:16 pm -
1 stop6h 40m
Mon 11/3012:29 pm -
1 stop5h 36m
Deal found 10/20![Delta logo]()
$293
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:55 am -
2 stops5h 50m
Thu 11/265:40 am -
2 stops5h 45m
Deal found 10/22![Southwest logo]()
$294
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:49 pm -
1 stop5h 09m
Sat 11/285:00 am -
1 stop5h 34m
Deal found 10/22![American Airlines logo]()
$353
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:25 am -
2 stops9h 19m
Thu 11/266:00 am -
1 stop4h 39m
Deal found 10/22![American Airlines logo]()
$365
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:25 pm -
1 stop5h 30m
Sat 11/285:30 am -
2 stops8h 55m
Deal found 10/22![Southwest logo]()
$377
Best flights from Panama City to St. LouisDiscover carefully curated flight deals from Panama City to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
Discover carefully curated flight deals from Panama City to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/116:00 am -
1 stop5h 29m
Sun 12/135:31 pm -
1 stop5h 46m
Deal found 10/20![Delta logo]()
$269
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/115:05 pm -
1 stop7h 30m
Sun 12/131:25 pm -
2 stops7h 10m
Deal found 10/20![Southwest logo]()
$274
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/267:25 am -
1 stop4h 53m
Sun 11/296:00 am -
1 stop5h 37m
Deal found 10/24![American Airlines logo]()
$390
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/203:05 pm -
1 stop7h 21m
Sun 11/228:30 am -
1 stop5h 58m
Deal found 10/22![United Airlines logo]()
$437
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:16 pm -
1 stop6h 40m
Mon 11/3012:29 pm -
1 stop5h 36m
Deal found 10/20![Delta logo]()
$293
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:00 am -
2 stops7h 15m
Thu 11/265:40 am -
2 stops5h 45m
Deal found 10/21![Southwest logo]()
$294
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:00 am -
2 stops7h 15m
Mon 11/94:30 pm -
1 stop4h 05m
Deal found 10/21![Southwest logo]()
$418
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:49 pm -
1 stop5h 09m
Mon 11/302:48 pm -
2 stops8h 59m
Deal found 10/20![American Airlines logo]()
$472
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/193:05 pm -
3 stops24h 38m
Thu 11/265:00 am -
2 stops9h 28m
Deal found 10/22![United Airlines logo]()
$517
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/63:58 pm -
1 stop7h 35m
Sun 11/86:00 am -
1 stop5h 41m
Deal found 10/20![American Airlines logo]()
$485
Last-minute flights from Panama City to St. LouisDiscover last-minute flight deals from Panama City to St. Louis. Data last updated October 25, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to St. Louis. Data last updated October 25, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/284:07 pm -
1 stop5h 53m
Tue 11/35:00 am -
1 stop6h 41m
Deal found 10/22![American Airlines logo]()
$397
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:00 am -
1 stop4h 51m
Mon 11/96:00 am -
1 stop4h 30m
Deal found 10/21![Delta logo]()
$413
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/194:55 pm -
1 stop5h 30m
Thu 11/268:30 am -
1 stop7h 48m
Deal found 10/22![United Airlines logo]()
$249
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:55 am -
2 stops5h 50m
Thu 11/265:40 am -
2 stops5h 45m
Deal found 10/22![Southwest logo]()
$294
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:25 am -
2 stops9h 19m
Thu 11/266:00 am -
1 stop4h 39m
Deal found 10/22![American Airlines logo]()
$365
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/204:55 pm -
1 stop5h 31m
Fri 11/278:30 am -
1 stop5h 58m
Deal found 10/23![United Airlines logo]()
$265
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:49 pm -
1 stop5h 09m
Sat 11/285:00 am -
1 stop5h 34m
Deal found 10/22![American Airlines logo]()
$353
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:25 pm -
1 stop5h 30m
Sat 11/285:30 am -
2 stops8h 55m
Deal found 10/22![Southwest logo]()
$377
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:16 pm -
1 stop6h 40m
Mon 11/3012:29 pm -
1 stop5h 36m
Deal found 10/20![Delta logo]()
$293
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/267:25 am -
1 stop4h 53m
Sun 11/296:00 am -
1 stop5h 37m
Deal found 10/24![American Airlines logo]()
$390
One-way flights from Panama City to St. LouisSearch for one-way flight options from Panama City to St. Louis. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
Search for one-way flight options from Panama City to St. Louis. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/242:58 pm -
1 stop7h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![United Airlines logo]()
$125
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2410:05 am -
2 stops9h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![Southwest logo]()
$130
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/47:02 pm -
1 stop4h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![American Airlines logo]()
$207
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/411:25 am -
2 stops7h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Southwest logo]()
$275
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/61:33 pm -
1 stop8h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![American Airlines logo]()
$289
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/611:25 am -
2 stops7h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Southwest logo]()
$294
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/304:00 pm -
Nonstop1h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Southwest logo]()
$340
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/45:28 pm -
3 stops16h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![United Airlines logo]()
$566
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/296:55 pm -
1 stop5h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Delta logo]()
$570
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/296:55 am -
2 stops8h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Southwest logo]()
$775
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/79:06 am -
3 stops12h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![United Airlines logo]()
$846
Find flight deals from Panama City to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 25, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $249 (United Airlines) |
One-way from | $125 (United Airlines) |
Popular in | October |
Cheapest in | December |
Average price | $556 |
Good one-way deal | $247 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CitySt. Louis
ECP Panama City NW Florida Beaches - STL Lambert-St Louis
ECPSTL
Panama City NW Florida Beaches
Thu 12/24
2:58 pm-10:30 pm
1 stop7h 32m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$125
Panama CitySt. Louis
ECP Panama City NW Florida Beaches - STL Lambert-St Louis
ECPSTL
Panama City NW Florida Beaches
Thu 12/24
10:05 am-7:30 pm
2 stops9h 25m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$130
Panama CitySt. Louis
ECP Panama City NW Florida Beaches - STL Lambert-St Louis
ECPSTL
Panama City NW Florida Beaches
Fri 12/11
6:00 am-11:29 am
1 stop5h 29m
Lambert-St Louis
Sun 12/13
5:31 pm-11:17 pm
1 stop5h 46m
$269
Panama CitySt. Louis
ECP Panama City NW Florida Beaches - STL Lambert-St Louis
ECPSTL
Panama City NW Florida Beaches
Fri 12/11
5:05 pm-12:35 am
1 stop7h 30m
Lambert-St Louis
Sun 12/13
1:25 pm-8:35 pm
2 stops7h 10m
$274
Panama CitySt. Louis
ECP Panama City NW Florida Beaches - STL Lambert-St Louis
ECPSTL
Panama City NW Florida Beaches
Wed 11/25
5:16 pm-11:56 pm
1 stop6h 40m
Lambert-St Louis
Mon 11/30
12:29 pm-6:05 pm
1 stop5h 36m
$293
Panama CitySt. Louis
ECP Panama City NW Florida Beaches - STL Lambert-St Louis
ECPSTL
Panama City NW Florida Beaches
Mon 11/23
7:00 am-2:15 pm
2 stops7h 15m
Lambert-St Louis
Thu 11/26
5:40 am-11:25 am
2 stops5h 45m
$294
Quickest round-trip
Panama CitySt. Louis
ECP Panama City NW Florida Beaches - STL Lambert-St Louis
ECPSTL
Panama City NW Florida Beaches
Sat 10/31
10:30 am-12:20 pm
Nonstop1h 50m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$340
Panama CitySt. Louis
ECP Panama City NW Florida Beaches - STL Lambert-St Louis
ECPSTL
Panama City NW Florida Beaches
Fri 10/30
7:15 am-1:50 pm
1 stop6h 35m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$340
Panama CitySt. Louis
ECP Panama City NW Florida Beaches - STL Lambert-St Louis
ECPSTL
Panama City NW Florida Beaches
Thu 11/26
7:25 am-12:18 pm
1 stop4h 53m
Lambert-St Louis
Sun 11/29
6:00 am-11:37 am
1 stop5h 37m
$390
Panama CitySt. Louis
ECP Panama City NW Florida Beaches - STL Lambert-St Louis
ECPSTL
Panama City NW Florida Beaches
Thu 11/5
7:00 am-2:15 pm
2 stops7h 15m
Lambert-St Louis
Mon 11/9
4:30 pm-8:35 pm
1 stop4h 05m
$418
Showing 1-10 of 22 resultsSorted by cheapest first
Compare providers for flights from Panama City to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to St. Louis in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City, Florida-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City, Florida-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.
ECP-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to St. Louis
What is the cheapest month to book a flight from Panama City, Florida to St. Louis?
Currently, December is the cheapest month in which you can book a flight from Panama City, Florida to St. Louis (average of $282). Flying from Panama City, Florida to St. Louis in October is currently the most expensive (average of $556). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from ECP to STL?
Find hourly flight availability from Panama City to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 25, 2026.
A simple way to save on the total cost of your ticket is to fly from Panama City, Florida to St. Louis in the evening. If you’re flexible enough to do this you can expect to save up to 14% on your trip compared to booking a flight in the morning.
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated October 25, 2026.
See what other customers who have flown with Southwest and Delta from Panama City to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Comfort
8.0
Entertainment
7.4
Boarding
8.1
Crew
8.6
Overall
7.9
Reviews
1 / 20
10.0
ExcellentEdward,Sep 2026
MCO - BWI
Food
7.0
Comfort
8.0
Entertainment
7.4
Boarding
8.1
Crew
8.6
Overall
7.9
Reviews
1 / 20
10.0
ExcellentEdward,Sep 2026
MCO - BWI
Food
7.0
Comfort
8.0
Entertainment
7.4
Boarding
8.1
Crew
8.6
Overall
7.9
Reviews
1 / 20
10.0
ExcellentEdward,Sep 2026
MCO - BWI
Related info for your journey
Find useful and relevant information for your journey from Panama City to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsFairview Heights
O'Fallon
Fenton
Swansea
Eureka
Wentzville
Maryland Heights
Chesterfield
Collinsville
Edwardsville
Glencoe
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Panama City and St. Louis flights
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Top 2 airlines flying from Panama City to St. Louis
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| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$227 | Average$358 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$286 | Average$383 | FlexibilityNo cancel fee | On-timeN/A |