$105+ Cheap flights from Panama City, FL to St. Louis (ECP - STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/19. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — STL
May 28 — Jun 41
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Panama City to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to St. Louis
Cheapest
Best
Last-minute
One-way
Cheapest flights from Panama City to St. LouisExplore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 28, 2026.
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 28, 2026.
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:15 am
ECP
- STL
1 stop5h 35m
Southwest
Mon 6/111:15 am
STL
- ECP
1 stop10h 25m
Southwest
Deal found 4/22![Southwest logo]()
$278
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/69:23 am
ECP
- STL
1 stop6h 34m
Delta
Tue 9/86:00 am
STL
- ECP
1 stop4h 13m
Delta
Deal found 4/24![Delta logo]()
$315
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:45 pm
ECP
- STL
1 stop5h 14m
Delta
Wed 5/135:15 pm
STL
- ECP
1 stop5h 46m
Delta
Deal found 4/24![Delta logo]()
$317
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/77:05 pm
ECP
- STL
1 stop4h 32m
Delta
Tue 9/86:00 am
STL
- ECP
1 stop4h 13m
Delta
Deal found 4/24![Delta logo]()
$337
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/76:00 am
ECP
- STL
1 stop5h 50m
Southwest
Tue 8/111:55 pm
STL
- ECP
Nonstop1h 45m
Southwest
Deal found 4/26![Southwest logo]()
$338
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/511:43 am
ECP
- STL
1 stop5h 20m
American Airlines
Fri 5/86:54 pm
STL
- ECP
1 stop4h 52m
American Airlines
Deal found 4/23![American Airlines logo]()
$358
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/87:45 am
ECP
- STL
1 stop5h 08m
Delta
Wed 9/97:20 am
STL
- ECP
1 stop5h 19m
Delta
Deal found 4/24![Delta logo]()
$377
Best flights from Panama City to St. LouisDiscover carefully curated flight deals from Panama City to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 28, 2026.
Discover carefully curated flight deals from Panama City to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 28, 2026.
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:15 am
ECP
- STL
2 stops7h 55m
Southwest
Mon 6/111:15 am
STL
- ECP
1 stop10h 25m
Southwest
Deal found 4/22![Southwest logo]()
$283
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/246:41 pm
ECP
- STL
1 stop5h 12m
Delta
Wed 7/297:08 am
STL
- ECP
1 stop5h 23m
Delta
Deal found 4/25![Delta logo]()
$315
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1110:50 am
ECP
- STL
1 stop7h 14m
American Airlines
Wed 5/136:29 am
STL
- ECP
2 stops9h 34m
American Airlines
Deal found 4/24![American Airlines logo]()
$424
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/185:48 pm
ECP
- STL
1 stop5h 52m
Delta
Fri 7/246:58 pm
STL
- ECP
1 stop4h 39m
Delta
Deal found 4/24![Delta logo]()
$315
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:45 pm
ECP
- STL
1 stop5h 14m
Delta
Fri 5/157:01 pm
STL
- ECP
1 stop4h 27m
Delta
Deal found 4/26![Delta logo]()
$317
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/246:20 pm
ECP
- STL
1 stop5h 45m
Southwest
Wed 7/297:25 pm
STL
- ECP
Nonstop1h 45m
Southwest
Deal found 4/25![Southwest logo]()
$380
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/1110:30 am
ECP
- STL
Nonstop1h 50m
Southwest
Sat 8/1510:10 am
STL
- ECP
Nonstop1h 50m
Southwest
Deal found 4/26![Southwest logo]()
$401
This Southwest deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/188:30 am
ECP
- STL
2 stops10h 50m
Southwest
Fri 7/242:25 pm
STL
- ECP
1 stop5h 45m
Southwest
Deal found 4/24![Southwest logo]()
$402
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/205:55 pm
ECP
- STL
1 stop6h 40m
Southwest
Thu 7/232:25 pm
STL
- ECP
1 stop5h 45m
Southwest
Deal found 4/23![Southwest logo]()
$419
Last-minute flights from Panama City to St. LouisDiscover last-minute flight deals from Panama City to St. Louis. Data last updated April 28, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to St. Louis. Data last updated April 28, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:49 am
ECP
- STL
1 stop6h 07m
Delta
Sat 5/912:59 pm
STL
- ECP
1 stop5h 37m
Delta
Deal found 4/24![Delta logo]()
$378
This United Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/22:14 pm
ECP
- STL
1 stop6h 59m
United Airlines
Sat 5/910:25 am
STL
- ECP
2 stops11h 40m
United Airlines
Deal found 4/24![United Airlines logo]()
$383
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/210:48 am
ECP
- STL
2 stops9h 21m
American Airlines
Sat 5/92:33 pm
STL
- ECP
2 stops9h 13m
American Airlines
Deal found 4/24![American Airlines logo]()
$388
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/511:43 am
ECP
- STL
1 stop5h 20m
American Airlines
Fri 5/86:54 pm
STL
- ECP
1 stop4h 52m
American Airlines
Deal found 4/23![American Airlines logo]()
$358
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:45 pm
ECP
- STL
1 stop5h 14m
Delta
Wed 5/135:15 pm
STL
- ECP
1 stop5h 46m
Delta
Deal found 4/24![Delta logo]()
$317
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1110:50 am
ECP
- STL
1 stop7h 14m
American Airlines
Wed 5/136:29 am
STL
- ECP
2 stops9h 34m
American Airlines
Deal found 4/24![American Airlines logo]()
$424
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:15 am
ECP
- STL
1 stop5h 35m
Southwest
Mon 6/111:15 am
STL
- ECP
1 stop10h 25m
Southwest
Deal found 4/22![Southwest logo]()
$278
One-way flights from Panama City to St. LouisSearch for one-way flight options from Panama City to St. Louis. Find affordable one-way fares based on user searches. Data last updated April 28, 2026.
Search for one-way flight options from Panama City to St. Louis. Find affordable one-way fares based on user searches. Data last updated April 28, 2026.
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/192:50 pm
ECP
- STL
1 stop6h 48m
Delta
Deal found 4/23![Delta logo]()
$105
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/239:19 am
ECP
- STL
1 stop5h 32m
Delta
Deal found 4/23![Delta logo]()
$125
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1612:40 pm
ECP
- STL
1 stop6h 30m
Southwest
Deal found 4/23![Southwest logo]()
$141
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1911:43 am
ECP
- STL
2 stops11h 16m
American Airlines
Deal found 4/23![American Airlines logo]()
$150
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/225:08 pm
ECP
- STL
1 stop6h 48m
Delta
Deal found 4/23![Delta logo]()
$158
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/216:00 am
ECP
- STL
1 stop6h 20m
Delta
Deal found 4/23![Delta logo]()
$159
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/234:16 pm
ECP
- STL
2 stops7h 40m
American Airlines
Deal found 4/25![American Airlines logo]()
$163
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/275:08 pm
ECP
- STL
1 stop4h 32m
Delta
Deal found 4/26![Delta logo]()
$180
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/234:16 pm
ECP
- STL
2 stops7h 38m
American Airlines
Deal found 4/25![American Airlines logo]()
$185
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/217:00 pm
ECP
- STL
Nonstop1h 50m
Southwest
Deal found 4/27![Southwest logo]()
$199
Find flight deals from Panama City to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 28, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $278 (Southwest) |
One-way from | $105 (Delta) |
Popular in | April |
Cheapest in | October |
Average price | $469 |
Good round-trip deal | $432 or less |
Good one-way deal | $213 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 28, 2026.
Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Wed 5/27
7:15 am-3:10 pm
2 stops7h 55m
Lambert-St Louis
Mon 6/1
11:15 am-9:40 pm
1 stop10h 25m
$283
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Fri 7/24
6:41 pm-11:53 pm
1 stop5h 12m
Lambert-St Louis
Wed 7/29
7:08 am-12:31 pm
1 stop5h 23m
$315
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Sat 7/18
5:48 pm-11:40 pm
1 stop5h 52m
Lambert-St Louis
Fri 7/24
6:58 pm-11:37 pm
1 stop4h 39m
$315
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Mon 5/11
6:45 pm-11:59 pm
1 stop5h 14m
Lambert-St Louis
Fri 5/15
7:01 pm-11:28 pm
1 stop4h 27m
$317
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Fri 7/24
6:20 pm-12:05 am
1 stop5h 45m
Lambert-St Louis
Wed 7/29
7:25 pm-9:10 pm
Nonstop1h 45m
$380
Quickest round-trip
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Sat 7/11
10:30 am-12:20 pm
Nonstop1h 50m
Lambert-St Louis
Sat 8/15
10:10 am-12:00 pm
Nonstop1h 50m
$401
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Sat 7/18
8:30 am-7:20 pm
2 stops10h 50m
Lambert-St Louis
Fri 7/24
2:25 pm-8:10 pm
1 stop5h 45m
$402
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Mon 7/20
5:55 pm-12:35 am
1 stop6h 40m
Lambert-St Louis
Thu 7/23
2:25 pm-8:10 pm
1 stop5h 45m
$419
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Mon 5/11
10:50 am-6:04 pm
1 stop7h 14m
Lambert-St Louis
Wed 5/13
6:29 am-4:03 pm
2 stops9h 34m
$424
Cheapest one-way
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Sat 5/16
12:40 pm-7:10 pm
1 stop6h 30m
$141
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from Panama City to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to St. Louis in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City, Florida-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City, Florida-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.
ECP-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to St. Louis
What is the cheapest month to book a flight from Panama City, Florida to St. Louis?
Currently, October is the cheapest month in which you can book a flight from Panama City, Florida to St. Louis (average of $198). Flying from Panama City, Florida to St. Louis in April is currently the most expensive (average of $469). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from ECP to STL?
Find hourly flight availability from Panama City to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 28, 2026.
A simple way to save on the total cost of your ticket is to fly from Panama City, Florida to St. Louis at noon. If you’re flexible enough to do this you can expect to save up to 26% on your trip compared to booking a flight in the morning.
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated April 28, 2026.
See what other customers who have flown with Southwest and Delta from Panama City to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Panama City to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Festus
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Panama City
Popular flights
St. Louis flight routes
Alternative routes for Panama City to St. Louis
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Panama City to St. Louis by cabin class
Find flights from Panama City to St. Louis, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Panama City and St. Louis flights
Browse other Panama City and St. Louis flight options. Last updated on April 28, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on April 28, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 28, 2026.
Top 2 airlines flying from Panama City to St. Louis
Discover the top 2 airlines that operate flights from Panama City to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$157 | Average$358 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$206 | Average$350 | FlexibilityNo cancel fee | On-timeN/A |