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$105+ Cheap flights from Panama City, FL to St. Louis (ECP - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/8. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — STL
Jul 14 — Jul 211
Tue 7/14
Tue 7/21
1 adult, Economy
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Cheap flight deals from Panama City to St. Louis

Cheapest flights from Panama City to St. Louis
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 14, 2026.

This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:00 am
ECP
-
STL
1 stop4h 48m
Delta
Wed 10/141:30 pm
STL
-
ECP
1 stop6h 06m
Delta
Deal found 6/9$229
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:55 am
ECP
-
STL
Nonstop1h 50m
Southwest
Wed 10/148:35 am
STL
-
ECP
1 stop9h 00m
Southwest
Deal found 6/9$290
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:08 pm
ECP
-
STL
1 stop6h 48m
Delta
Wed 7/87:08 am
STL
-
ECP
1 stop3h 40m
Delta
Deal found 6/11$317
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/84:20 pm
ECP
-
STL
1 stop4h 50m
Southwest
Wed 7/227:25 pm
STL
-
ECP
Nonstop1h 50m
Southwest
Deal found 6/12$321
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/144:20 pm
ECP
-
STL
1 stop4h 50m
Southwest
Tue 7/215:40 am
STL
-
ECP
2 stops8h 10m
Southwest
Deal found 6/10$322
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/74:20 pm
ECP
-
STL
2 stops7h 25m
Southwest
Mon 7/135:40 am
STL
-
ECP
1 stop5h 10m
Southwest
Deal found 6/12$336
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/236:56 pm
ECP
-
STL
1 stop4h 56m
American Airlines
Sun 7/266:13 pm
STL
-
ECP
1 stop5h 24m
American Airlines
Deal found 6/11$338

Find flight deals from Panama City to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 14, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$229
(Delta)

One-way from

$105
(Delta)

Popular in

June

Cheapest in

October

Average price

$436

Good round-trip deal

$392 or less

Good one-way deal

$236 or less
Provider with most accurate pricing for Panama City NW Florida Beaches-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Lambert-St Louis flights.
Search Deals
From Panama City NW Florida Beaches to Lambert-St Louis
Search Deals
One-way flight from Panama City NW Florida Beaches to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($32 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2026
Search Deals
Price to beat on a round-trip flight from Panama City NW Florida Beaches to Lambert-St Louis.
Search Deals
Price to beat on a one-way flight from Panama City NW Florida Beaches to Lambert-St Louis.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 14, 2026.
Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Sat 10/10

6:00 am-10:48 am

1 stop4h 48m

Lambert-St Louis

Wed 10/14

1:30 pm-7:36 pm

1 stop6h 06m

$229

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Sat 10/10

5:55 am-7:45 am

Nonstop1h 50m

Lambert-St Louis

Wed 10/14

8:35 am-5:35 pm

1 stop9h 00m

$290

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Fri 10/9

4:10 pm-8:49 pm

1 stop4h 39m

Lambert-St Louis

Mon 10/12

3:42 pm-7:36 pm

1 stop3h 54m

$317
Quickest round-trip

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Tue 7/14

5:30 pm-7:20 pm

Nonstop1h 50m

Lambert-St Louis

Tue 7/21

10:15 am-3:40 pm

1 stop5h 25m

$321

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Wed 7/8

4:20 pm-11:45 pm

2 stops7h 25m

Lambert-St Louis

Wed 7/22

1:45 pm-7:45 pm

1 stop6h 00m

$322

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Tue 7/7

4:20 pm-11:45 pm

2 stops7h 25m

Lambert-St Louis

Mon 7/13

5:40 am-10:50 am

1 stop5h 10m

$336
Cheapest one-way

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Tue 8/11

7:45 am-4:25 pm

2 stops8h 40m

$111

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Mon 12/7

7:45 am-12:56 pm

1 stop5h 11m

$125

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Sat 12/5

1:30 pm-6:01 pm

1 stop4h 31m

$125

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Thu 9/10

6:00 am-9:36 am

1 stop3h 36m

$125

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/11

Showing 1-10 of 18 resultsSorted by cheapest first
1
2

Compare providers for flights from Panama City to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to St. Louis in June.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to St. Louis

What is the cheapest month to book a flight from Panama City, Florida to St. Louis?

Currently, October is the cheapest month in which you can book a flight from Panama City, Florida to St. Louis (average of $198). Flying from Panama City, Florida to St. Louis in June is currently the most expensive (average of $436). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to STL?

Find hourly flight availability from Panama City to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 14, 2026.

A simple way to save on the total cost of your ticket is to fly from Panama City, Florida to St. Louis at noon. If you’re flexible enough to do this you can expect to save up to 26% on your trip compared to booking a flight in the morning.

How much does it cost to fly round-trip from Panama City, Florida to St. Louis?

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated June 14, 2026.
See what other customers who have flown with Southwest and Delta from Panama City to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
7.9
Good
4,235 reviews

Food

7.0

Overall

7.9

Comfort

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

La Tracimeldamarcos,Jun 2026

LAX - SLC

The second flight was not as comfortable as the first as we had to change planes to what seemed to be a slightly older aircraft. The seats weren’t as comfortable as the other plane. But it wasn’t bad.
Southwest
7.9
Good
4,235 reviews
Southwest
7.9
Good
4,235 reviews

Food

7.0

Overall

7.9

Comfort

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

La Tracimeldamarcos,Jun 2026

LAX - SLC

The second flight was not as comfortable as the first as we had to change planes to what seemed to be a slightly older aircraft. The seats weren’t as comfortable as the other plane. But it wasn’t bad.
Delta
7.9
Good
8,405 reviews
Southwest
7.9
Good
4,235 reviews

Food

7.0

Overall

7.9

Comfort

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

La Tracimeldamarcos,Jun 2026

LAX - SLC

The second flight was not as comfortable as the first as we had to change planes to what seemed to be a slightly older aircraft. The seats weren’t as comfortable as the other plane. But it wasn’t bad.

Related info for your journey

Find useful and relevant information for your journey from Panama City to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to St. Louis?

    If you wish to fly to St. Louis from Panama City, then you need to book flights from Panama City NW Florida Beaches to Lambert-St Louis. There is 1 flight from NW Florida Beaches (ECP) to Lambert-St Louis (STL) per day to choose from. Flights to St. Louis from NW Florida Beaches are available from 2 different airlines, which means you should have some options if you want to compare airfare deals. 1h 50m is how long a nonstop flight from Panama City to Lambert-St Louis typically takes.

  • How popular is this Panama City, Florida to St. Louis flight route?

    The Panama City NW Florida Beaches to Lambert-St Louis flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City, Florida to St. Louis?

    For as low as $290, Delta can have you in St. Louis from Panama City, Florida in 1h 50m. Airlines will cover a distance of 635 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Panama City, Florida to St. Louis round-trip?

    Flying on Southwest is currently your cheapest option to St. Louis, with prices starting at $157. Another option worth looking into is Delta, starting at $206 round trip. Southwest is 50% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the cheapest airlines to fly from Panama City, Florida to St. Louis one-way?

    The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $83. However, be on the lookout for offers from Southwest and Delta, as they are both options that can get you from Panama City, Florida to St. Louis for a low price.

  • What are the cheapest flights from Panama City, Florida to St. Louis?

    Looking for the cheapest flight from Panama City, Florida to St. Louis? While on average our users pay $365, our data indicates the cheapest price to be $165. The most popular route (Panama City NW Florida Beaches - Lambert-St Louis), is priced around $317.

  • Can I find deals for flights from Panama City to St. Louis that include hotel bookings?

    Yes. In addition to deals on Panama City to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to St. Louis.

  • Can I find deals for business class flights from Panama City to St. Louis?

    Yes. Cheapflights offers flight deals from Panama City to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to St. Louis?

    Currently, October is the cheapest month in which you can book a flight from Panama City, Florida to St. Louis (average of $198). Flying from Panama City, Florida to St. Louis in June is currently the most expensive (average of $436). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Eureka
Maryland Heights
Collinsville
Wentzville
Glencoe
Chesterfield
Alton
Farmington

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Panama City to St. Louis

Discover the top 2 airlines that operate flights from Panama City to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 14, 2026.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$157Average$358FlexibilityNo cancel feeOn-time63%
DeltaCheapest$206Average$362FlexibilityNo cancel feeOn-timeN/A

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