$109+ Cheap flights from Panama City, FL to St. Louis (ECP - STL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/10. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — STL
Oct 11 — Oct 181
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to St. Louis
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Cheapest flights from Panama City to St. LouisExplore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2026.
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2026.
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:12 am -
1 stop3h 39m
Mon 10/262:25 pm -
1 stop6h 41m
Deal found 9/10![Delta logo]()
$237
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/611:41 am -
2 stops9h 40m
Tue 10/133:12 pm -
1 stop7h 06m
Deal found 9/7![United Airlines logo]()
$255
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:00 am -
1 stop4h 55m
Mon 10/125:35 pm -
1 stop3h 31m
Deal found 9/8![Delta logo]()
$283
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/133:20 pm -
Nonstop1h 50m
Tue 10/2012:55 pm -
Nonstop1h 45m
Deal found 9/8![Southwest logo]()
$295
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/63:20 pm -
Nonstop1h 50m
Tue 10/131:40 pm -
1 stop7h 05m
Deal found 9/7![Southwest logo]()
$305
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/94:00 pm -
Nonstop1h 50m
Mon 10/123:40 pm -
Nonstop1h 45m
Deal found 9/7![Southwest logo]()
$309
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:20 am -
2 stops9h 23m
Mon 10/266:15 am -
1 stop8h 08m
Deal found 9/9![United Airlines logo]()
$322
Best flights from Panama City to St. LouisDiscover carefully curated flight deals from Panama City to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 11, 2026.
Discover carefully curated flight deals from Panama City to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 11, 2026.
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:12 am -
1 stop3h 39m
Mon 10/262:25 pm -
1 stop6h 41m
Deal found 9/10![Delta logo]()
$237
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/63:20 pm -
Nonstop1h 50m
Tue 10/131:40 pm -
1 stop7h 05m
Deal found 9/7![Southwest logo]()
$305
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/24:55 pm -
1 stop5h 18m
Wed 2/37:30 am -
1 stop5h 47m
Deal found 9/10![United Airlines logo]()
$317
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:42 pm -
1 stop5h 17m
Mon 10/269:17 am -
2 stops9h 25m
Deal found 9/11![American Airlines logo]()
$360
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:12 am -
1 stop3h 39m
Tue 10/135:35 pm -
1 stop3h 31m
Deal found 9/7![Delta logo]()
$237
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:20 am -
2 stops9h 23m
Mon 10/266:15 am -
1 stop8h 08m
Deal found 9/9![United Airlines logo]()
$322
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/113:50 pm -
1 stop5h 15m
Sun 11/155:40 am -
1 stop5h 05m
Deal found 9/10![Southwest logo]()
$346
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/12:50 pm -
1 stop7h 40m
Wed 10/73:12 pm -
1 stop7h 06m
Deal found 9/9![United Airlines logo]()
$347
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/14:00 pm -
Nonstop1h 50m
Wed 10/712:55 pm -
Nonstop1h 45m
Deal found 9/9![Southwest logo]()
$358
Last-minute flights from Panama City to St. LouisDiscover last-minute flight deals from Panama City to St. Louis. Data last updated September 11, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to St. Louis. Data last updated September 11, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/611:41 am -
2 stops9h 40m
Tue 10/133:12 pm -
1 stop7h 06m
Deal found 9/7![United Airlines logo]()
$255
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/63:20 pm -
Nonstop1h 50m
Tue 10/131:40 pm -
1 stop7h 05m
Deal found 9/7![Southwest logo]()
$305
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:00 am -
1 stop4h 55m
Mon 10/125:35 pm -
1 stop3h 31m
Deal found 9/8![Delta logo]()
$283
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/94:00 pm -
Nonstop1h 50m
Mon 10/123:40 pm -
Nonstop1h 45m
Deal found 9/7![Southwest logo]()
$309
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/133:20 pm -
Nonstop1h 50m
Tue 10/2012:55 pm -
Nonstop1h 45m
Deal found 9/8![Southwest logo]()
$295
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:12 am -
1 stop3h 39m
Mon 10/262:25 pm -
1 stop6h 41m
Deal found 9/10![Delta logo]()
$237
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:20 am -
2 stops9h 23m
Mon 10/268:30 am -
1 stop7h 48m
Deal found 9/8![United Airlines logo]()
$322
One-way flights from Panama City to St. LouisSearch for one-way flight options from Panama City to St. Louis. Find affordable one-way fares based on user searches. Data last updated September 11, 2026.
Search for one-way flight options from Panama City to St. Louis. Find affordable one-way fares based on user searches. Data last updated September 11, 2026.
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/73:20 pm -
Nonstop1h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Southwest logo]()
$109
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:34 pm -
1 stop6h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Delta logo]()
$119
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/711:21 am -
1 stop5h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![Delta logo]()
$129
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/94:00 pm -
Nonstop1h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Southwest logo]()
$155
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:20 am -
2 stops14h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![United Airlines logo]()
$164
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/94:57 pm -
1 stop5h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![United Airlines logo]()
$165
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/97:35 pm -
1 stop4h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![Delta logo]()
$175
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/63:20 pm -
Nonstop1h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Southwest logo]()
$187
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:30 pm -
1 stop6h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Delta logo]()
$197
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:00 am -
1 stop4h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Delta logo]()
$200
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/611:41 am -
2 stops9h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![United Airlines logo]()
$202
Find flight deals from Panama City to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $237 (Delta) |
One-way from | $109 (Southwest) |
Popular in | June |
Cheapest in | December |
Average price | $317 |
Good round-trip deal | $368 or less |
Good one-way deal | $169 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 11, 2026.
Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Panama CitySt. Louis
ECP Panama City NW Florida Beaches - STL Lambert-St Louis
ECPSTL
Panama City NW Florida Beaches
Sat 10/10
5:55 am-7:45 am
Nonstop1h 50m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$109
Panama CitySt. Louis
ECP Panama City NW Florida Beaches - STL Lambert-St Louis
ECPSTL
Panama City NW Florida Beaches
Wed 11/4
6:00 am-10:51 am
1 stop4h 51m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$119
Panama CitySt. Louis
ECP Panama City NW Florida Beaches - STL Lambert-St Louis
ECPSTL
Panama City NW Florida Beaches
Sat 11/7
3:05 pm-10:26 pm
1 stop7h 21m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$119
Panama CitySt. Louis
ECP Panama City NW Florida Beaches - STL Lambert-St Louis
ECPSTL
Panama City NW Florida Beaches
Sat 12/12
7:50 am-12:40 pm
1 stop4h 50m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$119
Panama CitySt. Louis
ECP Panama City NW Florida Beaches - STL Lambert-St Louis
ECPSTL
Panama City NW Florida Beaches
Sat 12/12
6:00 am-11:29 am
1 stop5h 29m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$119
Panama CitySt. Louis
ECP Panama City NW Florida Beaches - STL Lambert-St Louis
ECPSTL
Panama City NW Florida Beaches
Tue 11/10
7:30 am-4:45 pm
2 stops9h 15m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$124
Panama CitySt. Louis
ECP Panama City NW Florida Beaches - STL Lambert-St Louis
ECPSTL
Panama City NW Florida Beaches
Mon 11/9
6:55 pm-11:56 pm
1 stop5h 01m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$129
Panama CitySt. Louis
ECP Panama City NW Florida Beaches - STL Lambert-St Louis
ECPSTL
Panama City NW Florida Beaches
Wed 10/7
11:21 am-4:28 pm
1 stop5h 07m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$129
Panama CitySt. Louis
ECP Panama City NW Florida Beaches - STL Lambert-St Louis
ECPSTL
Panama City NW Florida Beaches
Sat 12/12
1:30 pm-11:14 pm
2 stops9h 44m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$164
Panama CitySt. Louis
ECP Panama City NW Florida Beaches - STL Lambert-St Louis
ECPSTL
Panama City NW Florida Beaches
Fri 11/13
6:55 pm-11:56 pm
1 stop5h 01m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$175
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Panama City to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to St. Louis in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City, Florida-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City, Florida-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.
ECP-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to St. Louis
What is the cheapest month to book a flight from Panama City, Florida to St. Louis?
Currently, December is the cheapest month in which you can book a flight from Panama City, Florida to St. Louis (average of $262). Flying from Panama City, Florida to St. Louis in June is currently the most expensive (average of $444). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from ECP to STL?
Find hourly flight availability from Panama City to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2026.
A simple way to save on the total cost of your ticket is to fly from Panama City, Florida to St. Louis in the evening. If you’re flexible enough to do this you can expect to save up to 16% on your trip compared to booking a flight in the morning.
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated September 11, 2026.
See what other customers who have flown with Southwest and Delta from Panama City to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Comfort
8.0
Overall
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Entertainment
7.5
Comfort
8.0
Overall
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Entertainment
7.5
Comfort
8.0
Overall
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Related info for your journey
Find useful and relevant information for your journey from Panama City to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsFairview Heights
O'Fallon
Fenton
Swansea
Eureka
Maryland Heights
Collinsville
Wentzville
Edwardsville
Glencoe
Chesterfield
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Panama City and St. Louis flights
Browse other Panama City and St. Louis flight options. Last updated on September 11, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on September 11, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 11, 2026.
Top 2 airlines flying from Panama City to St. Louis
Discover the top 2 airlines that operate flights from Panama City to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$216 | Average$368 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$227 | Average$358 | FlexibilityNo cancel fee | On-time63% |