$114+ Cheap flights from Panama City, FL to St. Louis (ECP - STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/10. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — STL
Aug 12 — Aug 191
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to St. Louis
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Best
Last-minute
One-way
Cheapest flights from Panama City to St. LouisExplore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 13, 2026.
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 13, 2026.
This Southwest deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/215:10 pm
ECP
- STL
Nonstop1h 45m
Southwest
Mon 9/282:50 pm
STL
- ECP
Nonstop1h 45m
Southwest
Deal found 7/12![Southwest logo]()
$227
This Southwest deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:25 am
ECP
- STL
1 stop6h 20m
Southwest
Mon 10/262:20 pm
STL
- ECP
2 stops7h 50m
Southwest
Deal found 7/11![Southwest logo]()
$242
This Southwest deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/107:05 am
ECP
- STL
2 stops8h 15m
Southwest
Thu 8/202:00 pm
STL
- ECP
1 stop7h 35m
Southwest
Deal found 7/12![Southwest logo]()
$273
This American Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:48 pm
ECP
- STL
1 stop4h 52m
American Airlines
Thu 8/206:36 am
STL
- ECP
1 stop7h 34m
American Airlines
Deal found 7/10![American Airlines logo]()
$287
This Southwest deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:10 pm
ECP
- STL
Nonstop1h 45m
Southwest
Thu 8/202:15 pm
STL
- ECP
1 stop6h 45m
Southwest
Deal found 7/10![Southwest logo]()
$297
This Delta deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:00 am
ECP
- STL
1 stop3h 54m
Delta
Thu 8/135:23 pm
STL
- ECP
1 stop6h 07m
Delta
Deal found 7/8![Delta logo]()
$299
This Southwest deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/185:10 pm
ECP
- STL
Nonstop1h 45m
Southwest
Mon 9/212:50 pm
STL
- ECP
Nonstop1h 45m
Southwest
Deal found 7/9![Southwest logo]()
$321
Best flights from Panama City to St. LouisDiscover carefully curated flight deals from Panama City to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 13, 2026.
Discover carefully curated flight deals from Panama City to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 13, 2026.
This Southwest deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/105:10 pm
ECP
- STL
Nonstop1h 45m
Southwest
Thu 8/202:50 pm
STL
- ECP
Nonstop1h 45m
Southwest
Deal found 7/12![Southwest logo]()
$227
This Delta deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:25 am
ECP
- STL
1 stop5h 58m
Delta
Sat 10/105:28 pm
STL
- ECP
1 stop5h 50m
Delta
Deal found 7/12![Delta logo]()
$237
This Southwest deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:25 am
ECP
- STL
1 stop6h 20m
Southwest
Mon 10/262:20 pm
STL
- ECP
2 stops7h 50m
Southwest
Deal found 7/11![Southwest logo]()
$242
This Southwest deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:10 pm
ECP
- STL
Nonstop1h 45m
Southwest
Thu 8/202:15 pm
STL
- ECP
1 stop6h 45m
Southwest
Deal found 7/10![Southwest logo]()
$297
This Delta deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/96:00 am
ECP
- STL
1 stop3h 39m
Delta
Sat 8/155:33 pm
STL
- ECP
1 stop4h 07m
Delta
Deal found 7/8![Delta logo]()
$383
This Southwest deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/158:15 am
ECP
- STL
1 stop5h 00m
Southwest
Sat 8/154:20 pm
STL
- ECP
Nonstop1h 45m
Southwest
Deal found 7/10![Southwest logo]()
$347
This Southwest deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/211:30 pm
ECP
- STL
2 stops6h 25m
Southwest
Mon 9/285:15 am
STL
- ECP
2 stops7h 50m
Southwest
Deal found 7/12![Southwest logo]()
$353
This Southwest deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/54:00 pm
ECP
- STL
Nonstop1h 50m
Southwest
Fri 10/98:35 am
STL
- ECP
1 stop5h 55m
Southwest
Deal found 7/12![Southwest logo]()
$358
This Southwest deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/11:50 pm
ECP
- STL
1 stop5h 15m
Southwest
Thu 10/88:30 am
STL
- ECP
2 stops6h 00m
Southwest
Deal found 7/11![Southwest logo]()
$381
This Southwest deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/107:05 am
ECP
- STL
2 stops8h 15m
Southwest
Thu 8/133:45 pm
STL
- ECP
1 stop3h 15m
Southwest
Deal found 7/8![Southwest logo]()
$389
Last-minute flights from Panama City to St. LouisDiscover last-minute flight deals from Panama City to St. Louis. Data last updated July 13, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to St. Louis. Data last updated July 13, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/105:10 pm
ECP
- STL
Nonstop1h 45m
Southwest
Thu 8/202:50 pm
STL
- ECP
Nonstop1h 45m
Southwest
Deal found 7/12![Southwest logo]()
$227
This Delta deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:51 pm
ECP
- STL
1 stop5h 07m
Delta
Thu 8/203:39 pm
STL
- ECP
1 stop4h 29m
Delta
Deal found 7/12![Delta logo]()
$237
This Delta deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:00 am
ECP
- STL
1 stop3h 54m
Delta
Thu 8/135:23 pm
STL
- ECP
1 stop6h 07m
Delta
Deal found 7/8![Delta logo]()
$299
This Southwest deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/157:15 am
ECP
- STL
Nonstop1h 50m
Southwest
Sat 8/1510:10 am
STL
- ECP
Nonstop1h 50m
Southwest
Deal found 7/10![Southwest logo]()
$343
This American Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:48 pm
ECP
- STL
1 stop4h 52m
American Airlines
Thu 8/206:36 am
STL
- ECP
1 stop7h 34m
American Airlines
Deal found 7/10![American Airlines logo]()
$287
This Southwest deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:10 pm
ECP
- STL
Nonstop1h 45m
Southwest
Thu 8/202:15 pm
STL
- ECP
1 stop6h 45m
Southwest
Deal found 7/10![Southwest logo]()
$297
This Southwest deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/286:00 am
ECP
- STL
1 stop5h 50m
Southwest
Mon 8/312:50 pm
STL
- ECP
Nonstop1h 45m
Southwest
Deal found 7/12![Southwest logo]()
$336
One-way flights from Panama City to St. LouisSearch for one-way flight options from Panama City to St. Louis. Find affordable one-way fares based on user searches. Data last updated July 13, 2026.
Search for one-way flight options from Panama City to St. Louis. Find affordable one-way fares based on user searches. Data last updated July 13, 2026.
This Southwest deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/105:10 pm
ECP
- STL
Nonstop1h 45m
Southwest
Deal found 7/12![Southwest logo]()
$114
This Delta deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:51 pm
ECP
- STL
1 stop5h 07m
Delta
Deal found 7/12![Delta logo]()
$119
This Southwest deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/117:45 am
ECP
- STL
2 stops8h 40m
Southwest
Deal found 7/12![Southwest logo]()
$124
This Southwest deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/97:45 am
ECP
- STL
2 stops8h 40m
Southwest
Deal found 7/10![Southwest logo]()
$129
This American Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/65:48 pm
ECP
- STL
1 stop4h 52m
American Airlines
Deal found 7/8![American Airlines logo]()
$144
This Southwest deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/77:40 am
ECP
- STL
2 stops7h 20m
Southwest
Deal found 7/8![Southwest logo]()
$149
This Delta deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:00 am
ECP
- STL
1 stop5h 46m
Delta
Deal found 7/8![Delta logo]()
$157
This Delta deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/69:27 am
ECP
- STL
1 stop6h 50m
Delta
Deal found 7/9![Delta logo]()
$159
This American Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/75:48 pm
ECP
- STL
1 stop4h 52m
American Airlines
Deal found 7/8![American Airlines logo]()
$172
Find flight deals from Panama City to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $227 (Southwest) |
One-way from | $114 (Southwest) |
Popular in | June |
Cheapest in | August |
Average price | $316 |
Good round-trip deal | $390 or less |
Good one-way deal | $193 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 13, 2026.
Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Mon 8/10
5:10 pm-6:55 pm
Nonstop1h 45m
Lambert-St Louis
Thu 8/20
2:50 pm-4:35 pm
Nonstop1h 45m
$227
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Mon 10/5
7:25 am-1:23 pm
1 stop5h 58m
Lambert-St Louis
Sat 10/10
5:28 pm-11:18 pm
1 stop5h 50m
$237
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Thu 10/22
6:25 am-12:45 pm
1 stop6h 20m
Lambert-St Louis
Mon 10/26
2:20 pm-10:10 pm
2 stops7h 50m
$242
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Mon 8/17
5:10 pm-6:55 pm
Nonstop1h 45m
Lambert-St Louis
Thu 8/20
2:15 pm-9:00 pm
1 stop6h 45m
$297
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Sat 8/15
8:15 am-1:15 pm
1 stop5h 00m
Lambert-St Louis
Sat 8/15
4:20 pm-6:05 pm
Nonstop1h 45m
$347
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Mon 9/21
1:30 pm-7:55 pm
2 stops6h 25m
Lambert-St Louis
Mon 9/28
5:15 am-1:05 pm
2 stops7h 50m
$353
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Mon 10/5
4:00 pm-5:50 pm
Nonstop1h 50m
Lambert-St Louis
Fri 10/9
8:35 am-2:30 pm
1 stop5h 55m
$358
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Thu 10/1
1:50 pm-7:05 pm
1 stop5h 15m
Lambert-St Louis
Thu 10/8
8:30 am-2:30 pm
2 stops6h 00m
$381
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Sun 8/9
6:00 am-9:39 am
1 stop3h 39m
Lambert-St Louis
Sat 8/15
5:33 pm-9:40 pm
1 stop4h 07m
$383
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Mon 8/10
7:05 am-3:20 pm
2 stops8h 15m
Lambert-St Louis
Thu 8/13
3:45 pm-7:00 pm
1 stop3h 15m
$389
Showing 1-10 of 20 resultsSorted by cheapest first
Compare providers for flights from Panama City to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to St. Louis in July.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City, Florida-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City, Florida-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.
ECP-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to St. Louis
What is the cheapest month to book a flight from Panama City, Florida to St. Louis?
Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to St. Louis (average of $249). Flying from Panama City, Florida to St. Louis in June is currently the most expensive (average of $444). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from ECP to STL?
Find hourly flight availability from Panama City to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 13, 2026.
A simple way to save on the total cost of your ticket is to fly from Panama City, Florida to St. Louis at noon. If you’re flexible enough to do this you can expect to save up to 17% on your trip compared to booking a flight in the morning.
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated July 13, 2026.
See what other customers who have flown with Southwest and Delta from Panama City to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Entertainment
7.5
Overall
8.0
Comfort
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Crew
8.6
Entertainment
7.5
Overall
8.0
Comfort
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Crew
8.6
Entertainment
7.5
Overall
8.0
Comfort
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Related info for your journey
Find useful and relevant information for your journey from Panama City to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Eureka
Maryland Heights
Collinsville
Wentzville
Glencoe
Chesterfield
Alton
Farmington
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Panama City and St. Louis flights
Browse other Panama City and St. Louis flight options. Last updated on July 13, 2026.
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Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 13, 2026.
Top 2 airlines flying from Panama City to St. Louis
Discover the top 2 airlines that operate flights from Panama City to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$157 | Average$358 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$216 | Average$317 | FlexibilityNo cancel fee | On-timeN/A |