$105+ Cheap flights from St. Louis to Panama City, FL (STL - ECP)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/20. Fares are subject to change and may not be available on all flights or dates of travel.
STL — ECP
May 22 — May 291
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Lambert-St Louis to Panama City NW Florida Beaches are usually found in October or December, booked 44 days in advance, depart on a Tuesday or Wednesday and return on a Thursday
Cheap flight deals from St. Louis to Panama City
Cheapest
Best
Last-minute
One-way
Cheapest flights from St. Louis to Panama CityExplore the most affordable flight options available from St. Louis to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2026.
Explore the most affordable flight options available from St. Louis to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2026.
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/35:15 pm
STL
- ECP
1 stop5h 36m
Delta
Tue 6/97:46 am
ECP
- STL
1 stop4h 48m
Delta
Deal found 4/21![Delta logo]()
$209
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:12 pm
STL
- ECP
1 stop5h 28m
American Airlines
Tue 6/94:16 pm
ECP
- STL
2 stops7h 40m
American Airlines
Deal found 4/21![American Airlines logo]()
$214
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/307:05 pm
STL
- ECP
1 stop3h 46m
Delta
Wed 6/36:00 am
ECP
- STL
1 stop3h 44m
Delta
Deal found 4/20![Delta logo]()
$229
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2610:34 am
STL
- ECP
2 stops8h 16m
American Airlines
Tue 9/2912:12 pm
ECP
- STL
1 stop7h 34m
American Airlines
Deal found 4/20![American Airlines logo]()
$234
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:40 pm
STL
- ECP
Nonstop1h 45m
Southwest
Tue 6/95:25 pm
ECP
- STL
1 stop5h 35m
Southwest
Deal found 4/21![Southwest logo]()
$244
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/35:15 pm
STL
- ECP
1 stop5h 36m
Delta
Fri 6/56:00 am
ECP
- STL
1 stop3h 44m
Delta
Deal found 4/21![Delta logo]()
$248
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/187:01 pm
STL
- ECP
1 stop4h 27m
Delta
Sat 5/239:19 am
ECP
- STL
1 stop5h 32m
Delta
Deal found 4/21![Delta logo]()
$249
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/912:45 pm
STL
- ECP
2 stops7h 45m
Southwest
Mon 9/144:25 pm
ECP
- STL
1 stop6h 40m
Southwest
Deal found 4/21![Southwest logo]()
$258
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/42:25 pm
STL
- ECP
1 stop5h 45m
Southwest
Wed 6/105:25 pm
ECP
- STL
1 stop5h 35m
Southwest
Deal found 4/20![Southwest logo]()
$262
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/177:05 am
STL
- ECP
1 stop5h 45m
Delta
Wed 5/205:29 pm
ECP
- STL
1 stop6h 30m
Delta
Deal found 4/21![Delta logo]()
$263
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/158:25 am
STL
- ECP
1 stop6h 30m
Southwest
Wed 8/1911:30 am
ECP
- STL
2 stops8h 30m
Southwest
Deal found 4/21![Southwest logo]()
$264
Best flights from St. Louis to Panama CityDiscover carefully curated flight deals from St. Louis to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 22, 2026.
Discover carefully curated flight deals from St. Louis to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 22, 2026.
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/3012:59 pm
STL
- ECP
1 stop5h 37m
Delta
Wed 6/35:29 pm
ECP
- STL
1 stop6h 30m
Delta
Deal found 4/21![Delta logo]()
$229
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:40 pm
STL
- ECP
Nonstop1h 45m
Southwest
Mon 6/86:20 pm
ECP
- STL
1 stop5h 45m
Southwest
Deal found 4/21![Southwest logo]()
$294
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/29:23 am
STL
- ECP
2 stops10h 38m
United Airlines
Mon 6/810:25 am
ECP
- STL
1 stop5h 21m
United Airlines
Deal found 4/21![United Airlines logo]()
$326
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/187:01 pm
STL
- ECP
1 stop4h 27m
Delta
Sat 5/235:29 pm
ECP
- STL
1 stop6h 30m
Delta
Deal found 4/17![Delta logo]()
$315
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/157:15 am
STL
- ECP
1 stop5h 30m
Southwest
Fri 6/196:10 am
ECP
- STL
1 stop6h 00m
Southwest
Deal found 4/17![Southwest logo]()
$337
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/197:05 am
STL
- ECP
1 stop5h 45m
Delta
Sat 5/235:29 pm
ECP
- STL
1 stop6h 30m
Delta
Deal found 4/17![Delta logo]()
$315
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/184:35 pm
STL
- ECP
Nonstop1h 45m
Southwest
Sat 5/239:50 am
ECP
- STL
1 stop6h 35m
Southwest
Deal found 4/21![Southwest logo]()
$345
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/267:12 pm
STL
- ECP
1 stop4h 32m
Delta
Mon 6/299:19 am
ECP
- STL
1 stop5h 21m
Delta
Deal found 4/17![Delta logo]()
$315
This Delta deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/316:00 am
STL
- ECP
1 stop4h 53m
Delta
Thu 6/47:41 am
ECP
- STL
1 stop4h 39m
Delta
Deal found 4/18![Delta logo]()
$315
This Southwest deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/11:45 pm
STL
- ECP
2 stops6h 05m
Southwest
Fri 6/511:30 am
ECP
- STL
1 stop7h 40m
Southwest
Deal found 4/18![Southwest logo]()
$358
This Delta deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:50 pm
STL
- ECP
1 stop4h 22m
Delta
Wed 5/65:49 am
ECP
- STL
1 stop4h 45m
Delta
Deal found 4/19![Delta logo]()
$317
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:00 am
STL
- ECP
1 stop4h 51m
Delta
Sun 6/76:00 am
ECP
- STL
1 stop3h 46m
Delta
Deal found 4/20![Delta logo]()
$367
Last-minute flights from St. Louis to Panama CityDiscover last-minute flight deals from St. Louis to Panama City. Data last updated April 22, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Panama City. Data last updated April 22, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/87:01 pm
STL
- ECP
1 stop4h 27m
Delta
Mon 5/116:45 pm
ECP
- STL
1 stop5h 14m
Delta
Deal found 4/21![Delta logo]()
$283
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/166:20 am
STL
- ECP
1 stop11h 30m
Southwest
Tue 5/199:00 am
ECP
- STL
1 stop5h 30m
Southwest
Deal found 4/21![Southwest logo]()
$278
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/177:05 am
STL
- ECP
1 stop5h 45m
Delta
Wed 5/205:29 pm
ECP
- STL
1 stop6h 30m
Delta
Deal found 4/21![Delta logo]()
$263
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/187:01 pm
STL
- ECP
1 stop4h 27m
Delta
Sat 5/239:19 am
ECP
- STL
1 stop5h 32m
Delta
Deal found 4/21![Delta logo]()
$249
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:40 pm
STL
- ECP
Nonstop1h 45m
Southwest
Tue 5/266:25 pm
ECP
- STL
1 stop3h 35m
Southwest
Deal found 4/21![Southwest logo]()
$277
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/227:05 am
STL
- ECP
1 stop5h 45m
Delta
Wed 5/275:29 pm
ECP
- STL
1 stop4h 09m
Delta
Deal found 4/21![Delta logo]()
$284
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:00 am
STL
- ECP
1 stop4h 53m
Delta
Thu 6/47:41 am
ECP
- STL
1 stop4h 39m
Delta
Deal found 4/21![Delta logo]()
$268
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/307:05 pm
STL
- ECP
1 stop3h 46m
Delta
Wed 6/36:00 am
ECP
- STL
1 stop3h 44m
Delta
Deal found 4/20![Delta logo]()
$229
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:12 pm
STL
- ECP
1 stop5h 28m
American Airlines
Wed 6/34:16 pm
ECP
- STL
2 stops7h 38m
American Airlines
Deal found 4/20![American Airlines logo]()
$286
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/317:05 am
STL
- ECP
1 stop3h 48m
Delta
Thu 6/47:41 am
ECP
- STL
1 stop4h 39m
Delta
Deal found 4/20![Delta logo]()
$282
One-way flights from St. Louis to Panama CitySearch for one-way flight options from St. Louis to Panama City. Find affordable one-way fares based on user searches. Data last updated April 22, 2026.
Search for one-way flight options from St. Louis to Panama City. Find affordable one-way fares based on user searches. Data last updated April 22, 2026.
This Southwest deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/192:30 pm
STL
- ECP
1 stop4h 25m
Southwest
Deal found 4/19![Southwest logo]()
$105
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/187:01 pm
STL
- ECP
1 stop4h 27m
Delta
Deal found 4/20![Delta logo]()
$125
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:54 pm
STL
- ECP
1 stop4h 52m
American Airlines
Deal found 4/21![American Airlines logo]()
$145
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/195:45 am
STL
- ECP
2 stops8h 10m
Southwest
Deal found 4/20![Southwest logo]()
$154
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1912:59 pm
STL
- ECP
2 stops9h 53m
American Airlines
Deal found 4/20![American Airlines logo]()
$155
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/187:03 pm
STL
- ECP
1 stop3h 55m
Delta
Deal found 4/20![Delta logo]()
$158
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/177:05 am
STL
- ECP
1 stop5h 45m
Delta
Deal found 4/20![Delta logo]()
$159
This Southwest deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2612:45 pm
STL
- ECP
2 stops7h 45m
Southwest
Deal found 4/18![Southwest logo]()
$163
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:30 am
STL
- ECP
2 stops9h 48m
United Airlines
Deal found 4/21![United Airlines logo]()
$164
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/237:05 pm
STL
- ECP
1 stop3h 46m
Delta
Deal found 4/20![Delta logo]()
$180
Find flight deals from St. Louis to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 22, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $209 (Delta) |
One-way from | $105 (Southwest) |
Popular in | May |
Cheapest in | October |
Average price | $390 |
Good round-trip deal | $395 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2026.
Use the filters below to find and compare flights from St. Louis to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisPanama City
STL - ECP
STLECP
Lambert-St Louis
Sat 5/30
12:59 pm-6:36 pm
1 stop5h 37m
Panama City NW Florida Beaches
Wed 6/3
5:29 pm-11:59 pm
1 stop6h 30m
$229
Quickest round-trip
St. LouisPanama City
STL - ECP
STLECP
Lambert-St Louis
Tue 6/2
6:40 pm-8:25 pm
Nonstop1h 45m
Panama City NW Florida Beaches
Mon 6/8
6:20 pm-12:05 am
1 stop5h 45m
$294
St. LouisPanama City
STL - ECP
STLECP
Lambert-St Louis
Mon 5/18
7:01 pm-11:28 pm
1 stop4h 27m
Panama City NW Florida Beaches
Sat 5/23
5:29 pm-11:59 pm
1 stop6h 30m
$315
St. LouisPanama City
STL - ECP
STLECP
Lambert-St Louis
Tue 5/19
7:05 am-12:50 pm
1 stop5h 45m
Panama City NW Florida Beaches
Sat 5/23
5:29 pm-11:59 pm
1 stop6h 30m
$315
St. LouisPanama City
STL - ECP
STLECP
Lambert-St Louis
Fri 6/26
7:12 pm-11:44 pm
1 stop4h 32m
Panama City NW Florida Beaches
Mon 6/29
9:19 am-2:40 pm
1 stop5h 21m
$315
St. LouisPanama City
STL - ECP
STLECP
Lambert-St Louis
Sun 5/31
6:00 am-10:53 am
1 stop4h 53m
Panama City NW Florida Beaches
Thu 6/4
7:41 am-12:20 pm
1 stop4h 39m
$315
St. LouisPanama City
STL - ECP
STLECP
Lambert-St Louis
Mon 5/4
6:50 pm-11:12 pm
1 stop4h 22m
Panama City NW Florida Beaches
Wed 5/6
5:49 am-10:34 am
1 stop4h 45m
$317
St. LouisPanama City
STL - ECP
STLECP
Lambert-St Louis
Tue 6/2
9:23 am-8:01 pm
2 stops10h 38m
Panama City NW Florida Beaches
Mon 6/8
10:25 am-3:46 pm
1 stop5h 21m
$326
St. LouisPanama City
STL - ECP
STLECP
Lambert-St Louis
Mon 6/15
7:15 am-12:45 pm
1 stop5h 30m
Panama City NW Florida Beaches
Fri 6/19
6:10 am-12:10 pm
1 stop6h 00m
$337
St. LouisPanama City
STL - ECP
STLECP
Lambert-St Louis
Mon 5/18
4:35 pm-6:20 pm
Nonstop1h 45m
Panama City NW Florida Beaches
Sat 5/23
9:50 am-4:25 pm
1 stop6h 35m
$345
Showing 1-10 of 22 resultsSorted by cheapest first
Compare providers for flights from St. Louis to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Panama City in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Panama City, Florida flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from St. Louis with our price prediction graph.
STL-ECP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Panama City
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How far ahead should I book a flight from St. Louis to Panama City, Florida?
Use this chart to determine the optimal time to book a round-trip flight from St. Louis to Panama City. Price data was last updated on April 17, 2026.
The price you pay for your flight from St. Louis to Panama City, Florida may vary depending on when you book. For the best chance of a lower fare, look to book 44 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from St. Louis to Panama City, Florida?
Currently, October is the cheapest month in which you can book a flight from St. Louis to Panama City, Florida (average of $279). Flying from St. Louis to Panama City, Florida in May is currently the most expensive (average of $407). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from STL to ECP?
Find hourly flight availability from St. Louis to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 22, 2026.
It’s typically best to fly out from St. Louis to Panama City, Florida in the afternoon. Doing so could potentially save you 14% on the flight price compared to flying at noon, which is usually more expensive.
What’s the top layover airport for flights from St. Louis to Panama City, Florida?
Share of 1-stop round-trip flights from St. Louis to Panama City, Florida chosen by Cheapflights users in the past 12 months, using the same layover each way.
Houston (IAH) – chosen by Cheapflights users on 50% of 1-stop itineraries from St. Louis to Panama City, Florida on Cheapflights.
What’s the cheapest layover airport for flights from St. Louis to Panama City, Florida?
Average round-trip fare for 1-stop flights from St. Louis to Panama City, Florida, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Nashville (BNA) is the most affordable 1-stop option, with an average round-trip price of $288.
What’s the fastest layover option from St. Louis to Panama City, Florida?
Shortest average travel time for 1-stop one-way flights from St. Louis to Panama City, Florida, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Nashville (BNA) have the shortest average one-way travel time for 1-stop routes: 3h 40m.
Which airport typically offers the quickest layover for flights from St. Louis to Panama City, Florida?
Average layover duration for 1-stop one-way flights from St. Louis to Panama City, Florida, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Houston (IAH) offer the fastest connection on this route, with an average layover time of 0h 55m.
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated April 22, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andAmerican Airlines from St. Louis to Panama City to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Overall
8.0
Comfort
8.0
Entertainment
7.5
Food
7.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Overall
8.0
Comfort
8.0
Entertainment
7.5
Food
7.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Overall
8.0
Comfort
8.0
Entertainment
7.5
Food
7.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Overall
8.0
Comfort
8.0
Entertainment
7.5
Food
7.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Panama City?
Book flights to Panama City if you plan to visit one of these locationsMexico Beach
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St. Louis and Panama City flights
Browse other St. Louis and Panama City flight options. Last updated on April 22, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on April 22, 2026.
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Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 22, 2026.
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Top 3 airlines flying from St. Louis to Panama City
Discover the top 3 airlines that operate flights from St. Louis to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$176 | Average$289 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$186 | Average$338 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$201 | Average$419 | FlexibilityNo cancel fee | On-time63% |