$184+ Cheap flights from St. Louis to Key West (STL - EYW)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/24. Fares are subject to change and may not be available on all flights or dates of travel.
STL — EYW
Jun 9 — Jun 161
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from St. Louis to Key West with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Key West
Cheapest
Best
Last-minute
One-way
Cheapest flights from St. Louis to Key WestExplore the most affordable flight options available from St. Louis to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 10, 2026.
Explore the most affordable flight options available from St. Louis to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/34:19 pm
STL
- EYW
1 stop19h 57m
Multiple Airlines
Wed 6/1011:46 am
EYW
- STL
2 stops30h 44m
Multiple Airlines
Deal found 5/6![Multiple Airlines logo]()
$253
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/304:19 pm
STL
- EYW
1 stop18h 06m
Multiple Airlines
Fri 6/51:11 pm
EYW
- STL
2 stops20h 44m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$287
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/71:22 pm
STL
- EYW
1 stop5h 29m
Delta
Tue 7/146:18 pm
EYW
- STL
1 stop6h 35m
Delta
Deal found 5/9![Delta logo]()
$293
This American Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/711:00 am
STL
- EYW
1 stop7h 06m
American Airlines
Tue 7/141:47 pm
EYW
- STL
2 stops8h 08m
American Airlines
Deal found 5/9![American Airlines logo]()
$298
This Kiwi.com deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/44:17 pm
STL
- EYW
1 stop18h 08m
Multiple Airlines
Wed 7/811:46 am
EYW
- STL
2 stops30h 51m
Multiple Airlines
Deal found 5/7![Multiple Airlines logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/74:19 pm
STL
- EYW
1 stop21h 16m
Multiple Airlines
Wed 6/105:07 pm
EYW
- STL
2 stops25h 23m
Multiple Airlines
Deal found 5/6![Multiple Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/74:19 pm
STL
- EYW
1 stop21h 16m
Multiple Airlines
Thu 6/114:02 pm
EYW
- STL
2 stops41h 50m
Multiple Airlines
Deal found 5/6![Multiple Airlines logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/114:17 pm
STL
- EYW
1 stop21h 18m
Multiple Airlines
Tue 6/161:14 pm
EYW
- STL
2 stops20h 38m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$312
Best flights from St. Louis to Key WestDiscover carefully curated flight deals from St. Louis to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 10, 2026.
Discover carefully curated flight deals from St. Louis to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 10, 2026.
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/71:22 pm
STL
- EYW
1 stop5h 29m
Delta
Tue 7/146:18 pm
EYW
- STL
1 stop6h 35m
Delta
Deal found 5/9![Delta logo]()
$293
This American Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/711:00 am
STL
- EYW
1 stop7h 06m
American Airlines
Tue 7/141:47 pm
EYW
- STL
2 stops8h 08m
American Airlines
Deal found 5/9![American Airlines logo]()
$298
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/46:33 pm
STL
- EYW
2 stops15h 54m
Multiple Airlines
Thu 6/1112:05 pm
EYW
- STL
1 stop12h 44m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$389
This United Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:00 am
STL
- EYW
1 stop6h 30m
United Airlines
Thu 6/43:55 pm
EYW
- STL
1 stop6h 26m
United Airlines
Deal found 5/6![United Airlines logo]()
$429
This Delta deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/310:51 am
STL
- EYW
1 stop5h 36m
Delta
Tue 7/76:18 pm
EYW
- STL
1 stop4h 57m
Delta
Deal found 5/7![Delta logo]()
$331
This Kiwi.com deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/14:09 pm
STL
- EYW
1 stop18h 16m
Multiple Airlines
Thu 8/612:05 pm
EYW
- STL
1 stop12h 54m
Multiple Airlines
Deal found 5/9![Multiple Airlines logo]()
$390
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/121:39 pm
STL
- EYW
1 stop5h 14m
Delta
Wed 6/176:24 pm
EYW
- STL
1 stop6h 32m
Delta
Deal found 5/5![Delta logo]()
$362
This American Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:15 am
STL
- EYW
1 stop6h 26m
American Airlines
Mon 6/17:29 pm
EYW
- STL
1 stop5h 15m
American Airlines
Deal found 5/7![American Airlines logo]()
$448
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:00 am
STL
- EYW
1 stop6h 29m
Delta
Sun 7/197:50 am
EYW
- STL
1 stop5h 27m
Delta
Deal found 5/5![Delta logo]()
$431
This Delta deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/149:15 am
STL
- EYW
1 stop7h 08m
Delta
Sat 5/166:19 pm
EYW
- STL
1 stop6h 40m
Delta
Deal found 5/10![Delta logo]()
$462
Last-minute flights from St. Louis to Key WestDiscover last-minute flight deals from St. Louis to Key West. Data last updated May 10, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Key West. Data last updated May 10, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/34:19 pm
STL
- EYW
1 stop19h 57m
Multiple Airlines
Wed 6/1011:46 am
EYW
- STL
2 stops30h 44m
Multiple Airlines
Deal found 5/6![Multiple Airlines logo]()
$253
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/31:27 pm
STL
- EYW
1 stop5h 22m
Delta
Wed 6/106:24 pm
EYW
- STL
1 stop6h 32m
Delta
Deal found 5/6![Delta logo]()
$343
This Kiwi.com deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/55:27 pm
STL
- EYW
2 stops39h 57m
Multiple Airlines
Fri 6/1212:07 pm
EYW
- STL
1 stop12h 42m
Multiple Airlines
Deal found 5/9![Multiple Airlines logo]()
$328
This Kiwi.com deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/74:19 pm
STL
- EYW
1 stop21h 16m
Multiple Airlines
Wed 6/105:07 pm
EYW
- STL
2 stops25h 23m
Multiple Airlines
Deal found 5/6![Multiple Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/74:19 pm
STL
- EYW
1 stop21h 16m
Multiple Airlines
Thu 6/114:02 pm
EYW
- STL
2 stops41h 50m
Multiple Airlines
Deal found 5/6![Multiple Airlines logo]()
$305
This Delta deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/910:51 am
STL
- EYW
1 stop5h 36m
Delta
Tue 6/166:24 pm
EYW
- STL
1 stop6h 32m
Delta
Deal found 5/10![Delta logo]()
$293
This American Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/96:15 am
STL
- EYW
2 stops8h 52m
American Airlines
Tue 6/165:37 pm
EYW
- STL
1 stop7h 22m
American Airlines
Deal found 5/10![American Airlines logo]()
$298
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/114:17 pm
STL
- EYW
1 stop21h 18m
Multiple Airlines
Tue 6/161:14 pm
EYW
- STL
2 stops20h 38m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$312
This Kiwi.com deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/274:17 pm
STL
- EYW
1 stop19h 59m
Multiple Airlines
Fri 7/312:07 pm
EYW
- STL
2 stops21h 45m
Multiple Airlines
Deal found 5/6![Multiple Airlines logo]()
$322
One-way flights from St. Louis to Key WestSearch for one-way flight options from St. Louis to Key West. Find affordable one-way fares based on user searches. Data last updated May 10, 2026.
Search for one-way flight options from St. Louis to Key West. Find affordable one-way fares based on user searches. Data last updated May 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/245:06 pm
STL
- EYW
3 stops39h 35m
Multiple Airlines
Deal found 5/9![Multiple Airlines logo]()
$184
This Kiwi.com deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/124:09 pm
STL
- EYW
1 stop18h 18m
Multiple Airlines
Deal found 5/7![Multiple Airlines logo]()
$191
This Kiwi.com deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/159:18 pm
STL
- EYW
2 stops37h 07m
Multiple Airlines
Deal found 5/7![Multiple Airlines logo]()
$230
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/1510:51 am
STL
- EYW
1 stop5h 32m
Delta
Deal found 5/5![Delta logo]()
$348
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/157:31 am
STL
- EYW
2 stops10h 35m
American Airlines
Deal found 5/5![American Airlines logo]()
$353
This Delta deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:00 am
STL
- EYW
1 stop5h 27m
Delta
Deal found 5/7![Delta logo]()
$365
This American Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:29 am
STL
- EYW
2 stops9h 06m
American Airlines
Deal found 5/7![American Airlines logo]()
$370
Find flight deals from St. Louis to Key West
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Key West (EYW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $253 (Kiwi.com) |
One-way from | $184 (Kiwi.com) |
Popular in | October |
Cheapest in | December |
Average price | $449 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 10, 2026.
Use the filters below to find and compare flights from St. Louis to Key West that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Tue 7/7
1:22 pm-7:51 pm
1 stop5h 29m
Key West
Tue 7/14
6:18 pm-11:53 pm
1 stop6h 35m
$293
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Tue 7/7
11:00 am-7:06 pm
1 stop7h 06m
Key West
Tue 7/14
1:47 pm-8:55 pm
2 stops8h 08m
$298
Quickest round-trip
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Fri 7/3
10:51 am-5:27 pm
1 stop5h 36m
Key West
Tue 7/7
6:18 pm-10:15 pm
1 stop4h 57m
$331
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Fri 6/12
1:39 pm-7:53 pm
1 stop5h 14m
Key West
Wed 6/17
6:24 pm-11:56 pm
1 stop6h 32m
$362
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Thu 6/4
6:33 pm-11:27 am
2 stops15h 54m
Key West
Thu 6/11
12:05 pm-11:49 pm
1 stop12h 44m
$389
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Sat 8/1
4:09 pm-11:25 am
1 stop18h 16m
Key West
Thu 8/6
12:05 pm-11:59 pm
1 stop12h 54m
$390
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Sat 5/30
6:00 am-1:30 pm
1 stop6h 30m
Key West
Thu 6/4
3:55 pm-9:21 pm
1 stop6h 26m
$429
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Fri 7/17
6:00 am-1:29 pm
1 stop6h 29m
Key West
Sun 7/19
7:50 am-12:17 pm
1 stop5h 27m
$431
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Fri 5/29
6:15 am-1:41 pm
1 stop6h 26m
Key West
Mon 6/1
7:29 pm-11:44 pm
1 stop5h 15m
$448
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Thu 5/14
9:15 am-5:23 pm
1 stop7h 08m
Key West
Sat 5/16
6:19 pm-11:59 pm
1 stop6h 40m
$462
Showing 1-10 of 17 resultsSorted by cheapest first
Compare providers for flights from St. Louis to Key West
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Key West in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-Key West flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Key West flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Key West flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Key West flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Key West flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Key West
Have a flexible travel schedule? Discover the best time to fly to Key West from St. Louis with our price prediction graph.
STL-EYW
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Key West
How far ahead should I book a flight from St. Louis to Key West?
Booking 33 days in advance of your planned departure date is, on average, the best time to get cheap flights from St. Louis to Key West. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from St. Louis to Key West?
Currently, December is the cheapest month in which you can book a flight from St. Louis to Key West (average of $283). Flying from St. Louis to Key West in October is currently the most expensive (average of $561). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from St. Louis to Key West?
Reviews of airlines servicing Key West
Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated May 10, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from St. Louis to Key West by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Overall
7.9
Boarding
8.1
Food
7.2
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Comfort
7.8
Overall
7.9
Boarding
8.1
Food
7.2
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Comfort
7.8
Overall
7.9
Boarding
8.1
Food
7.2
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Comfort
7.8
Overall
7.9
Boarding
8.1
Food
7.2
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Key West flight routes
Other flight options
Other flights from St. Louis
Popular flights
Alternative routes for St. Louis to Key West
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Key West by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from St. Louis to Key West by cabin class
Find flights from St. Louis to Key West, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Key West
Explore flights to Key West departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 10, 2026.
St. Louis and Key West flights
Browse other St. Louis and Key West flight options. Last updated on May 10, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on May 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from St. Louis to Key West
Discover the top 3 airlines that operate flights from St. Louis to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$222 | Average$398 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$228 | Average$399 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$262 | Average$463 | FlexibilityNo cancel fee | On-time69% |