$279+ Cheap flights from Key West to St. Louis (EYW - STL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/22. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — STL
Oct 8 — Oct 151
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Key West to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Key West to St. Louis
Cheapest
Best
Last-minute
One-way
Cheapest flights from Key West to St. LouisExplore the most affordable flight options available from Key West to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 8, 2026.
Explore the most affordable flight options available from Key West to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 8, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/210:59 am -
1 stop6h 35m
Thu 10/84:30 pm -
1 stop16h 49m
Deal found 9/3![Multiple Airlines logo]()
$388
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:27 pm -
1 stop5h 15m
Sat 9/268:43 am -
1 stop8h 12m
Deal found 9/7![American Airlines logo]()
$403
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2010:59 am -
1 stop6h 35m
Thu 9/2412:27 pm -
2 stops20h 52m
Deal found 9/5![Multiple Airlines logo]()
$537
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/210:21 am -
2 stops8h 09m
Thu 10/85:00 am -
2 stops10h 58m
Deal found 9/3![American Airlines logo]()
$716
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/201:47 pm -
2 stops10h 54m
Thu 9/246:30 am -
2 stops10h 25m
Deal found 9/5![American Airlines logo]()
$1,036
Best flights from Key West to St. LouisDiscover carefully curated flight deals from Key West to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 8, 2026.
Discover carefully curated flight deals from Key West to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 8, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/210:59 am -
1 stop6h 35m
Thu 10/84:30 pm -
1 stop16h 49m
Deal found 9/3![Multiple Airlines logo]()
$388
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/221:47 pm -
2 stops7h 57m
Sat 9/266:53 am -
1 stop5h 18m
Deal found 9/7![American Airlines logo]()
$411
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2010:59 am -
1 stop6h 35m
Thu 9/2412:27 pm -
2 stops20h 52m
Deal found 9/5![Multiple Airlines logo]()
$537
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/210:21 am -
2 stops8h 09m
Thu 10/85:00 am -
2 stops10h 58m
Deal found 9/3![American Airlines logo]()
$716
Last-minute flights from Key West to St. LouisDiscover last-minute flight deals from Key West to St. Louis. Data last updated September 8, 2026 and is based on user searches.
Discover last-minute flight deals from Key West to St. Louis. Data last updated September 8, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2010:59 am -
1 stop6h 35m
Thu 9/2412:27 pm -
2 stops20h 52m
Deal found 9/5![Multiple Airlines logo]()
$537
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/201:47 pm -
2 stops10h 54m
Thu 9/246:30 am -
2 stops10h 25m
Deal found 9/5![American Airlines logo]()
$1,036
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:27 pm -
1 stop5h 15m
Sat 9/268:43 am -
1 stop8h 12m
Deal found 9/7![American Airlines logo]()
$403
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/210:59 am -
1 stop6h 35m
Thu 10/84:30 pm -
1 stop16h 49m
Deal found 9/3![Multiple Airlines logo]()
$388
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/210:21 am -
2 stops8h 09m
Thu 10/85:00 am -
2 stops10h 58m
Deal found 9/3![American Airlines logo]()
$716
One-way flights from Key West to St. LouisSearch for one-way flight options from Key West to St. Louis. Find affordable one-way fares based on user searches. Data last updated September 8, 2026.
Search for one-way flight options from Key West to St. Louis. Find affordable one-way fares based on user searches. Data last updated September 8, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/225:20 pm -
3 stops45h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Multiple Airlines logo]()
$279
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/254:10 pm -
1 stop6h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![United Airlines logo]()
$524
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/255:28 pm -
2 stops7h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![American Airlines logo]()
$570
Find flight deals from Key West to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 8, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $388 (Kiwi.com) |
One-way from | $279 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Key West to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 8, 2026.
Use the filters below to find and compare flights from Key West to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Key WestSt. Louis
EYW Key West - STL Lambert-St Louis
EYWSTL
Key West
Tue 12/22
12:01 pm-7:09 am
2 stops20h 08m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$294
Key WestSt. Louis
EYW Key West - STL Lambert-St Louis
EYWSTL
Key West
Fri 10/2
10:59 am-4:34 pm
1 stop6h 35m
Lambert-St Louis
Thu 10/8
4:30 pm-10:19 am
1 stop16h 49m
$388
Key WestSt. Louis
EYW Key West - STL Lambert-St Louis
EYWSTL
Key West
Tue 9/22
1:47 pm-8:44 pm
2 stops7h 57m
Lambert-St Louis
Sat 9/26
6:53 am-1:11 pm
1 stop5h 18m
$411
Quickest round-trip
Key WestSt. Louis
EYW Key West - STL Lambert-St Louis
EYWSTL
Key West
Sun 10/25
4:10 pm-9:40 pm
1 stop6h 30m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$524
Key WestSt. Louis
EYW Key West - STL Lambert-St Louis
EYWSTL
Key West
Sun 9/20
10:59 am-4:34 pm
1 stop6h 35m
Lambert-St Louis
Thu 9/24
12:27 pm-10:19 am
2 stops20h 52m
$537
Key WestSt. Louis
EYW Key West - STL Lambert-St Louis
EYWSTL
Key West
Sun 10/25
5:28 pm-11:59 pm
2 stops7h 31m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$570
Key WestSt. Louis
EYW Key West - STL Lambert-St Louis
EYWSTL
Key West
Fri 10/2
10:21 am-5:30 pm
2 stops8h 09m
Lambert-St Louis
Thu 10/8
5:00 am-4:58 pm
2 stops10h 58m
$716
Sorted by cheapest first
Compare providers for flights from Key West to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Key West to St. Louis in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Key West-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Key West-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Key West-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Key West-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Key West to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Key West with our price prediction graph.
EYW-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from Key West to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsFairview Heights
O'Fallon
Fenton
Swansea
Eureka
Maryland Heights
Collinsville
Wentzville
Edwardsville
Glencoe
Chesterfield
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Key West
Popular flights
St. Louis flight routes