$289+ Cheap flights from Key West to St. Louis (EYW - STL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/22. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — STL
Nov 18 — Nov 251
Round-trip
1 adult, Economy
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Find cheap flights from Key West to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Key West to St. Louis
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Best
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One-way
Cheapest flights from Key West to St. LouisExplore the most affordable flight options available from Key West to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 19, 2026.
Explore the most affordable flight options available from Key West to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 19, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2411:04 am -
1 stop13h 55m
Fri 12/412:02 pm -
2 stops45h 17m
Deal found 10/19![Multiple Airlines logo]()
$335
This Kiwi.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1910:59 am -
1 stop13h 17m
Sun 11/226:05 pm -
1 stop15h 14m
Deal found 10/18![Multiple Airlines logo]()
$336
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:08 pm -
1 stop6h 48m
Tue 12/112:36 pm -
1 stop6h 25m
Deal found 10/19![Delta logo]()
$343
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2310:59 am -
1 stop14h 00m
Fri 12/412:02 pm -
2 stops45h 17m
Deal found 10/19![Multiple Airlines logo]()
$346
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2310:59 am -
1 stop14h 00m
Wed 12/26:13 pm -
1 stop15h 06m
Deal found 10/19![Multiple Airlines logo]()
$357
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2411:04 am -
1 stop13h 55m
Thu 12/36:13 pm -
1 stop15h 06m
Deal found 10/19![Multiple Airlines logo]()
$358
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2510:59 am -
1 stop14h 00m
Thu 12/36:13 pm -
1 stop15h 06m
Deal found 10/19![Multiple Airlines logo]()
$368
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:08 pm -
1 stop6h 48m
Tue 12/112:36 pm -
1 stop6h 25m
Deal found 10/19![Delta logo]()
$371
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2411:04 am -
1 stop13h 55m
Wed 12/27:58 pm -
2 stops13h 21m
Deal found 10/19![Multiple Airlines logo]()
$375
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2310:59 am -
1 stop14h 00m
Thu 12/36:13 pm -
1 stop15h 06m
Deal found 10/19![Multiple Airlines logo]()
$379
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2411:04 am -
1 stop13h 55m
Mon 11/306:35 pm -
2 stops14h 44m
Deal found 10/19![Multiple Airlines logo]()
$385
Best flights from Key West to St. LouisDiscover carefully curated flight deals from Key West to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 19, 2026.
Discover carefully curated flight deals from Key West to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 19, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1910:59 am -
1 stop13h 17m
Sun 11/226:05 pm -
1 stop15h 14m
Deal found 10/15![Multiple Airlines logo]()
$353
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:08 pm -
1 stop6h 48m
Tue 12/112:36 pm -
1 stop6h 25m
Deal found 10/19![Delta logo]()
$371
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/204:10 pm -
1 stop8h 14m
Sun 11/225:28 pm -
3 stops19h 24m
Deal found 10/19![United Airlines logo]()
$663
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:08 pm -
1 stop6h 48m
Fri 12/412:36 pm -
1 stop6h 25m
Deal found 10/19![Delta logo]()
$412
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/12:33 pm -
2 stops33h 43m
Thu 11/54:26 pm -
1 stop16h 53m
Deal found 10/16![Multiple Airlines logo]()
$478
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:08 pm -
1 stop6h 48m
Tue 12/112:36 pm -
1 stop6h 25m
Deal found 10/19![Delta logo]()
$462
This American Airlines deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/87:00 pm -
1 stop15h 55m
Tue 11/105:00 am -
2 stops9h 06m
Deal found 10/17![American Airlines logo]()
$1,249
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:08 pm -
1 stop6h 48m
Fri 12/412:36 pm -
1 stop6h 25m
Deal found 10/19![Delta logo]()
$531
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/192:50 pm -
1 stop8h 02m
Sun 11/225:28 pm -
3 stops19h 24m
Deal found 10/15![United Airlines logo]()
$663
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2511:43 am -
2 stops12h 39m
Thu 12/36:03 am -
2 stops10h 07m
Deal found 10/19![Delta logo]()
$1,009
Last-minute flights from Key West to St. LouisDiscover last-minute flight deals from Key West to St. Louis. Data last updated October 19, 2026 and is based on user searches.
Discover last-minute flight deals from Key West to St. Louis. Data last updated October 19, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1910:59 am -
1 stop13h 17m
Sun 11/226:05 pm -
1 stop15h 14m
Deal found 10/18![Multiple Airlines logo]()
$336
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2310:59 am -
1 stop14h 00m
Fri 12/412:02 pm -
2 stops45h 17m
Deal found 10/19![Multiple Airlines logo]()
$346
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2310:59 am -
1 stop14h 00m
Wed 12/26:13 pm -
1 stop15h 06m
Deal found 10/19![Multiple Airlines logo]()
$357
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2310:59 am -
1 stop14h 00m
Thu 12/36:13 pm -
1 stop15h 06m
Deal found 10/19![Multiple Airlines logo]()
$379
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2411:04 am -
1 stop13h 55m
Fri 12/412:02 pm -
2 stops45h 17m
Deal found 10/19![Multiple Airlines logo]()
$335
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2411:04 am -
1 stop13h 55m
Thu 12/36:13 pm -
1 stop15h 06m
Deal found 10/19![Multiple Airlines logo]()
$358
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:08 pm -
1 stop6h 48m
Tue 12/112:36 pm -
1 stop6h 25m
Deal found 10/19![Delta logo]()
$371
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2411:04 am -
1 stop13h 55m
Wed 12/27:58 pm -
2 stops13h 21m
Deal found 10/19![Multiple Airlines logo]()
$375
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2411:04 am -
1 stop13h 55m
Mon 11/306:35 pm -
2 stops14h 44m
Deal found 10/19![Multiple Airlines logo]()
$385
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:08 pm -
1 stop6h 48m
Tue 12/112:36 pm -
1 stop6h 25m
Deal found 10/19![Delta logo]()
$343
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2510:59 am -
1 stop14h 00m
Thu 12/36:13 pm -
1 stop15h 06m
Deal found 10/19![Multiple Airlines logo]()
$368
One-way flights from Key West to St. LouisSearch for one-way flight options from Key West to St. Louis. Find affordable one-way fares based on user searches. Data last updated October 19, 2026.
Search for one-way flight options from Key West to St. Louis. Find affordable one-way fares based on user searches. Data last updated October 19, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/2210:59 am -
1 stop14h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![Multiple Airlines logo]()
$289
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/224:45 pm -
1 stop6h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![United Airlines logo]()
$383
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/224:45 pm -
1 stop8h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/15![American Airlines logo]()
$403
Find flight deals from Key West to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 19, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $335 (Kiwi.com) |
One-way from | $289 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Key West to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 19, 2026.
Use the filters below to find and compare flights from Key West to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Key WestSt. Louis
EYW Key West - STL Lambert-St Louis
EYWSTL
Key West
Mon 3/22
10:59 am-10:20 am
2 stops48h 21m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$341
Key WestSt. Louis
EYW Key West - STL Lambert-St Louis
EYWSTL
Key West
Thu 11/19
10:59 am-11:16 pm
1 stop13h 17m
Lambert-St Louis
Sun 11/22
6:05 pm-10:19 am
1 stop15h 14m
$353
Key WestSt. Louis
EYW Key West - STL Lambert-St Louis
EYWSTL
Key West
Tue 11/24
6:08 pm-11:56 pm
1 stop6h 48m
Lambert-St Louis
Tue 12/1
12:36 pm-8:01 pm
1 stop6h 25m
$371
Quickest round-trip
Key WestSt. Louis
EYW Key West - STL Lambert-St Louis
EYWSTL
Key West
Mon 3/22
4:45 pm-10:12 pm
1 stop6h 27m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$383
Key WestSt. Louis
EYW Key West - STL Lambert-St Louis
EYWSTL
Key West
Mon 3/22
4:45 pm-11:46 pm
1 stop8h 01m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$403
Key WestSt. Louis
EYW Key West - STL Lambert-St Louis
EYWSTL
Key West
Wed 11/25
6:08 pm-11:56 pm
1 stop6h 48m
Lambert-St Louis
Fri 12/4
12:36 pm-8:01 pm
1 stop6h 25m
$412
Key WestSt. Louis
EYW Key West - STL Lambert-St Louis
EYWSTL
Key West
Mon 11/23
6:08 pm-11:56 pm
1 stop6h 48m
Lambert-St Louis
Tue 12/1
12:36 pm-8:01 pm
1 stop6h 25m
$462
Key WestSt. Louis
EYW Key West - STL Lambert-St Louis
EYWSTL
Key West
Sun 11/1
2:33 pm-11:16 pm
2 stops33h 43m
Lambert-St Louis
Thu 11/5
4:26 pm-10:19 am
1 stop16h 53m
$478
Key WestSt. Louis
EYW Key West - STL Lambert-St Louis
EYWSTL
Key West
Mon 11/23
6:08 pm-11:56 pm
1 stop6h 48m
Lambert-St Louis
Fri 12/4
12:36 pm-8:01 pm
1 stop6h 25m
$531
Key WestSt. Louis
EYW Key West - STL Lambert-St Louis
EYWSTL
Key West
Fri 11/20
4:10 pm-11:24 pm
1 stop8h 14m
Lambert-St Louis
Sun 11/22
5:28 pm-1:52 pm
3 stops19h 24m
$663
Showing 1-10 of 13 resultsSorted by cheapest first
Compare providers for flights from Key West to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Key West to St. Louis in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Key West-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Key West-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Key West-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Key West-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Key West to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Key West with our price prediction graph.
EYW-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from Key West to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsFairview Heights
O'Fallon
Fenton
Swansea
Eureka
Wentzville
Maryland Heights
Chesterfield
Collinsville
Edwardsville
Glencoe
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