$156+ Cheap flights from Des Moines to Key West (DSM - EYW)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/21. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
Mar 5 — Mar 121
1 adult, Economy
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Find cheap flights from Des Moines to Key West with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Key West
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Best
Last-minute
One-way
Cheapest flights from Des Moines to Key WestExplore the most affordable flight options available from Des Moines to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.
Explore the most affordable flight options available from Des Moines to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/251:52 pm
DSM
- EYW
1 stop7h 45m
American Airlines
Wed 4/14:40 pm
EYW
- DSM
1 stop6h 19m
American Airlines
Deal found 2/2![American Airlines logo]()
$289
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/27:00 am
DSM
- EYW
2 stops11h 15m
American Airlines
Tue 3/106:49 pm
EYW
- DSM
1 stop5h 51m
American Airlines
Deal found 2/1![American Airlines logo]()
$294
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/410:04 am
DSM
- EYW
2 stops11h 18m
American Airlines
Wed 3/113:56 pm
EYW
- DSM
2 stops8h 44m
American Airlines
Deal found 2/1![American Airlines logo]()
$300
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/201:52 pm
DSM
- EYW
1 stop7h 45m
American Airlines
Tue 3/246:49 pm
EYW
- DSM
1 stop5h 51m
American Airlines
Deal found 2/3![American Airlines logo]()
$309
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/237:00 am
DSM
- EYW
2 stops11h 12m
American Airlines
Tue 3/316:49 pm
EYW
- DSM
1 stop5h 59m
American Airlines
Deal found 2/2![American Airlines logo]()
$314
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/212:02 pm
DSM
- EYW
1 stop7h 35m
American Airlines
Wed 2/2512:55 pm
EYW
- DSM
2 stops9h 56m
American Airlines
Deal found 2/2![American Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/42:00 pm
DSM
- EYW
1 stop7h 22m
American Airlines
Mon 3/93:56 pm
EYW
- DSM
2 stops8h 44m
American Airlines
Deal found 2/2![American Airlines logo]()
$324
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/237:00 am
DSM
- EYW
1 stop7h 57m
American Airlines
Mon 3/306:49 pm
EYW
- DSM
1 stop5h 59m
American Airlines
Deal found 2/2![American Airlines logo]()
$329
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/186:20 am
DSM
- EYW
1 stop7h 31m
United Airlines
Thu 4/234:38 pm
EYW
- DSM
1 stop7h 05m
United Airlines
Deal found 2/3![United Airlines logo]()
$333
Best flights from Des Moines to Key WestDiscover carefully curated flight deals from Des Moines to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 3, 2026.
Discover carefully curated flight deals from Des Moines to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 3, 2026.
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/410:04 am
DSM
- EYW
2 stops11h 18m
American Airlines
Wed 3/116:49 pm
EYW
- DSM
1 stop5h 51m
American Airlines
Deal found 2/1![American Airlines logo]()
$294
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2411:09 am
DSM
- EYW
2 stops10h 49m
American Airlines
Tue 4/286:49 pm
EYW
- DSM
1 stop6h 00m
American Airlines
Deal found 2/1![American Airlines logo]()
$294
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/236:00 am
DSM
- EYW
1 stop8h 26m
American Airlines
Tue 3/316:49 pm
EYW
- DSM
1 stop5h 59m
American Airlines
Deal found 2/2![American Airlines logo]()
$309
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/212:02 pm
DSM
- EYW
1 stop7h 35m
American Airlines
Wed 2/256:53 pm
EYW
- DSM
1 stop5h 47m
American Airlines
Deal found 2/2![American Airlines logo]()
$314
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/256:00 am
DSM
- EYW
2 stops8h 57m
American Airlines
Wed 4/12:06 pm
EYW
- DSM
1 stop8h 53m
American Airlines
Deal found 2/1![American Airlines logo]()
$321
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/237:00 am
DSM
- EYW
1 stop7h 57m
American Airlines
Mon 3/306:49 pm
EYW
- DSM
1 stop5h 59m
American Airlines
Deal found 2/2![American Airlines logo]()
$329
Last-minute flights from Des Moines to Key WestDiscover last-minute flight deals from Des Moines to Key West. Data last updated February 3, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Key West. Data last updated February 3, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/212:02 pm
DSM
- EYW
1 stop7h 35m
American Airlines
Wed 2/2512:55 pm
EYW
- DSM
2 stops9h 56m
American Airlines
Deal found 2/2![American Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/27:00 am
DSM
- EYW
2 stops11h 15m
American Airlines
Tue 3/106:49 pm
EYW
- DSM
1 stop5h 51m
American Airlines
Deal found 2/1![American Airlines logo]()
$294
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/410:04 am
DSM
- EYW
2 stops11h 18m
American Airlines
Wed 3/113:56 pm
EYW
- DSM
2 stops8h 44m
American Airlines
Deal found 2/1![American Airlines logo]()
$300
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/42:00 pm
DSM
- EYW
1 stop7h 22m
American Airlines
Mon 3/93:56 pm
EYW
- DSM
2 stops8h 44m
American Airlines
Deal found 2/2![American Airlines logo]()
$324
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/201:52 pm
DSM
- EYW
1 stop7h 45m
American Airlines
Tue 3/246:49 pm
EYW
- DSM
1 stop5h 51m
American Airlines
Deal found 2/3![American Airlines logo]()
$309
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/237:00 am
DSM
- EYW
2 stops11h 12m
American Airlines
Tue 3/316:49 pm
EYW
- DSM
1 stop5h 59m
American Airlines
Deal found 2/2![American Airlines logo]()
$314
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/237:00 am
DSM
- EYW
1 stop7h 57m
American Airlines
Mon 3/306:49 pm
EYW
- DSM
1 stop5h 59m
American Airlines
Deal found 2/2![American Airlines logo]()
$329
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/251:52 pm
DSM
- EYW
1 stop7h 45m
American Airlines
Wed 4/14:40 pm
EYW
- DSM
1 stop6h 19m
American Airlines
Deal found 2/2![American Airlines logo]()
$289
One-way flights from Des Moines to Key WestSearch for one-way flight options from Des Moines to Key West. Find affordable one-way fares based on user searches. Data last updated February 3, 2026.
Search for one-way flight options from Des Moines to Key West. Find affordable one-way fares based on user searches. Data last updated February 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/216:14 pm
DSM
- EYW
1 stop19h 05m
Allegiant Air
Deal found 2/2![Allegiant Air logo]()
$156
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/218:30 am
DSM
- EYW
3 stops24h 51m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$421
Find flight deals from Des Moines to Key West
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Key West (EYW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $289 (American Airlines) |
One-way from | $156 (Kiwi.com) |
Popular in | June |
Cheapest in | September |
Average price | $578 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Des Moines to Key West that are best for you.
Fly from
Des Moines
Fly to
Key West
Route
Depart
Return
Price
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Wed 3/4
10:04 am-10:22 pm
2 stops11h 18m
Key West
Wed 3/11
6:49 pm-11:40 pm
1 stop5h 51m
$294
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Fri 4/24
11:09 am-10:58 pm
2 stops10h 49m
Key West
Tue 4/28
6:49 pm-11:49 pm
1 stop6h 00m
$294
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Mon 3/23
6:00 am-3:26 pm
1 stop8h 26m
Key West
Tue 3/31
6:49 pm-11:48 pm
1 stop5h 59m
$309
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Sat 2/21
2:02 pm-10:37 pm
1 stop7h 35m
Key West
Wed 2/25
6:53 pm-11:40 pm
1 stop5h 47m
$314
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Wed 3/25
6:00 am-3:57 pm
2 stops8h 57m
Key West
Wed 4/1
2:06 pm-9:59 pm
1 stop8h 53m
$321
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Mon 3/23
7:00 am-3:57 pm
1 stop7h 57m
Key West
Mon 3/30
6:49 pm-11:48 pm
1 stop5h 59m
$329
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Sat 2/21
6:14 pm-2:19 pm
1 stop19h 05m
$156
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Sat 2/21
8:30 am-10:21 am
3 stops24h 51m
$421
Compare providers for flights from Des Moines to Key West
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Key West in February.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Key West flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Key West flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Key West flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Key West flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Key West flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Key West
Have a flexible travel schedule? Discover the best time to fly to Key West from Des Moines with our price prediction graph.
DSM-EYW
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Key West
How far ahead should I book a flight from Des Moines to Key West?
Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Key West. Price data was last updated on January 30, 2026.
The price you pay for your flight from Des Moines to Key West may vary depending on when you book. For the best chance of a lower fare, look to book 35 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Des Moines to Key West?
Currently, July is the cheapest month in which you can book a flight from Des Moines to Key West (average of $82). Flying from Des Moines to Key West in December is currently the most expensive (average of $371). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Key West
Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated February 3, 2026.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Des Moines to Key West to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Comfort
7.9
Overall
7.9
Entertainment
7.8
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Crew
8.5
Comfort
7.9
Overall
7.9
Entertainment
7.8
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Crew
8.5
Comfort
7.9
Overall
7.9
Entertainment
7.8
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Crew
8.5
Comfort
7.9
Overall
7.9
Entertainment
7.8
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Crew
8.5
Comfort
7.9
Overall
7.9
Entertainment
7.8
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes for Des Moines to Key West
See prices for flight routes from nearby airports that may be better suited for you.
Top 4 airlines flying from Des Moines to Key West
Discover the top 4 airlines that operate flights from Des Moines to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$76 | Average$174 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$268 | Average$534 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$268 | Average$498 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$281 | Average$454 | FlexibilityNo cancel fee | On-time69% |