$345+ Cheap flights from Des Moines to Key West (DSM - EYW)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/5. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
Nov 20 — Nov 271
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Key West with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Key West
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Cheapest flights from Des Moines to Key WestExplore the most affordable flight options available from Des Moines to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 21, 2026.
Explore the most affordable flight options available from Des Moines to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 21, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/512:59 pm -
1 stop21h 21m
Wed 12/94:40 pm -
2 stops25h 06m
Deal found 10/16![Multiple Airlines logo]()
$345
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:30 am -
1 stop8h 51m
Wed 12/96:35 pm -
1 stop5h 24m
Deal found 10/20![American Airlines logo]()
$349
This Kiwi.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/42:50 pm -
1 stop25h 46m
Wed 12/910:45 am -
2 stops31h 01m
Deal found 10/18![Multiple Airlines logo]()
$355
This Kiwi.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/512:59 pm -
1 stop21h 21m
Thu 12/107:22 pm -
1 stop19h 48m
Deal found 10/18![Allegiant Air logo]()
$368
This Kiwi.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/42:50 pm -
1 stop25h 46m
Thu 12/107:22 pm -
1 stop19h 48m
Deal found 10/18![Allegiant Air logo]()
$376
This American Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/411:38 am -
1 stop6h 11m
Wed 12/96:35 pm -
1 stop5h 24m
Deal found 10/18![American Airlines logo]()
$394
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1411:09 am -
1 stop5h 47m
Thu 11/195:05 pm -
1 stop8h 14m
Deal found 10/20![American Airlines logo]()
$398
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/811:35 am -
1 stop7h 26m
Sat 12/126:06 pm -
1 stop5h 32m
Deal found 10/21![Delta logo]()
$419
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/88:00 am -
1 stop8h 44m
Sat 12/121:07 pm -
1 stop7h 27m
Deal found 10/20![American Airlines logo]()
$422
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:08 am -
1 stop8h 03m
Wed 11/45:50 pm -
1 stop6h 36m
Deal found 10/16![American Airlines logo]()
$429
Best flights from Des Moines to Key WestDiscover carefully curated flight deals from Des Moines to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 21, 2026.
Discover carefully curated flight deals from Des Moines to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 21, 2026.
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/89:23 am -
1 stop6h 23m
Sat 12/1210:14 am -
2 stops10h 15m
Deal found 10/20![American Airlines logo]()
$427
This Delta deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/411:35 am -
1 stop7h 26m
Tue 12/86:06 pm -
1 stop5h 32m
Deal found 10/18![Delta logo]()
$476
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/145:09 pm -
2 stops21h 20m
Wed 11/184:10 pm -
1 stop6h 45m
Deal found 10/16![United Airlines logo]()
$685
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:05 am -
2 stops9h 53m
Thu 11/57:18 pm -
1 stop5h 39m
Deal found 10/16![American Airlines logo]()
$472
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/55:24 am -
2 stops10h 57m
Tue 12/811:26 am -
2 stops13h 04m
Deal found 10/16![American Airlines logo]()
$515
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1511:35 am -
1 stop4h 35m
Wed 12/166:06 pm -
1 stop5h 32m
Deal found 10/21![Delta logo]()
$677
This American Airlines deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:00 am -
2 stops9h 27m
Sat 11/1410:18 am -
1 stop5h 28m
Deal found 10/17![American Airlines logo]()
$705
Last-minute flights from Des Moines to Key WestDiscover last-minute flight deals from Des Moines to Key West. Data last updated October 21, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Key West. Data last updated October 21, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:08 am -
1 stop8h 03m
Fri 11/64:44 pm -
1 stop8h 15m
Deal found 10/20![American Airlines logo]()
$494
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:08 am -
1 stop8h 03m
Wed 11/45:50 pm -
1 stop6h 36m
Deal found 10/16![American Airlines logo]()
$429
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:59 am -
1 stop23h 03m
Fri 11/610:14 am -
2 stops30h 19m
Deal found 10/20![Allegiant Air logo]()
$436
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/315:39 am -
1 stop7h 41m
Thu 11/56:11 pm -
1 stop5h 22m
Deal found 10/20![Delta logo]()
$433
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:05 am -
2 stops9h 53m
Thu 11/57:18 pm -
1 stop5h 39m
Deal found 10/20![American Airlines logo]()
$472
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1411:09 am -
1 stop5h 47m
Thu 11/195:05 pm -
1 stop8h 14m
Deal found 10/20![American Airlines logo]()
$398
This American Airlines deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1411:09 am -
1 stop5h 47m
Sat 11/217:16 pm -
1 stop6h 10m
Deal found 10/17![American Airlines logo]()
$471
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/278:00 am -
1 stop6h 29m
Thu 12/312:05 pm -
1 stop8h 14m
Deal found 10/18![United Airlines logo]()
$469
Find flight deals from Des Moines to Key West
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Key West (EYW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 21, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $345 (Kiwi.com) |
Popular in | May |
Cheapest in | July |
Average price | $546 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 21, 2026.
Use the filters below to find and compare flights from Des Moines to Key West that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesKey West
DSM Des Moines - EYW Key West
DSMEYW
Des Moines
Tue 12/8
9:23 am-4:46 pm
1 stop6h 23m
Key West
Sat 12/12
10:14 am-7:29 pm
2 stops10h 15m
$427
Des MoinesKey West
DSM Des Moines - EYW Key West
DSMEYW
Des Moines
Sat 10/31
6:05 am-4:58 pm
2 stops9h 53m
Key West
Thu 11/5
7:18 pm-11:57 pm
1 stop5h 39m
$472
Des MoinesKey West
DSM Des Moines - EYW Key West
DSMEYW
Des Moines
Fri 12/4
11:35 am-8:01 pm
1 stop7h 26m
Key West
Tue 12/8
6:06 pm-10:38 pm
1 stop5h 32m
$476
Des MoinesKey West
DSM Des Moines - EYW Key West
DSMEYW
Des Moines
Sat 12/5
5:24 am-5:21 pm
2 stops10h 57m
Key West
Tue 12/8
11:26 am-11:30 pm
2 stops13h 04m
$515
Quickest round-trip
Des MoinesKey West
DSM Des Moines - EYW Key West
DSMEYW
Des Moines
Tue 12/15
11:35 am-5:10 pm
1 stop4h 35m
Key West
Wed 12/16
6:06 pm-10:38 pm
1 stop5h 32m
$677
Des MoinesKey West
DSM Des Moines - EYW Key West
DSMEYW
Des Moines
Sat 11/14
5:09 pm-3:29 pm
2 stops21h 20m
Key West
Wed 11/18
4:10 pm-9:55 pm
1 stop6h 45m
$685
Des MoinesKey West
DSM Des Moines - EYW Key West
DSMEYW
Des Moines
Sat 11/7
6:00 am-4:27 pm
2 stops9h 27m
Key West
Sat 11/14
10:18 am-2:46 pm
1 stop5h 28m
$705
Sorted by cheapest first
Compare providers for flights from Des Moines to Key West
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Key West in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Key West flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Key West flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Key West flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Key West flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Key West flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Key West
Have a flexible travel schedule? Discover the best time to fly to Key West from Des Moines with our price prediction graph.
DSM-EYW
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Key West
What is the cheapest month to book a flight from Des Moines to Key West?
Currently, July is the cheapest month in which you can book a flight from Des Moines to Key West (average of $378). Flying from Des Moines to Key West in May is currently the most expensive (average of $676). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Key West?
Airfare is below average for this route at the moment.
Des Moines to Key West flights typically cost between $430 and $626 in December.The cheapest round-trip price found within the last 5 days was $345 on Multiple Airlines (Dec 5-Dec 9).
Reviews of airlines servicing Key West
Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated October 21, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAmerican Airlines from Des Moines to Key West to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Entertainment
7.8
Crew
8.5
Overall
7.8
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Food
7.2
Entertainment
7.8
Crew
8.5
Overall
7.8
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Food
7.2
Entertainment
7.8
Crew
8.5
Overall
7.8
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Food
7.2
Entertainment
7.8
Crew
8.5
Overall
7.8
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
Complete your trip to Key West by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Des Moines to Key West, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Key West
Explore flights to Key West departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 21, 2026.
Des Moines and Key West flights
Browse other Des Moines and Key West flight options. Last updated on October 21, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on October 21, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Des Moines to Key West
Discover the top 3 airlines that operate flights from Des Moines to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 21, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$288 | Average$454 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$305 | Average$474 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$338 | Average$558 | FlexibilityNo cancel fee | On-timeN/A |