$233+ Cheap flights from Des Moines to Key West (DSM - EYW)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/21. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
May 24 — May 311
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Key West with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Key West
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Best
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Cheapest flights from Des Moines to Key WestExplore the most affordable flight options available from Des Moines to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2026.
Explore the most affordable flight options available from Des Moines to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/211:00 am
DSM
- EYW
1 stop21h 06m
Multiple Airlines
Thu 5/71:57 pm
EYW
- DSM
2 stops34h 00m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$275
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:00 am
DSM
- EYW
1 stop8h 24m
American Airlines
Wed 5/277:29 pm
EYW
- DSM
1 stop5h 48m
American Airlines
Deal found 4/20![American Airlines logo]()
$289
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/241:05 pm
DSM
- EYW
1 stop8h 06m
United Airlines
Wed 10/282:30 pm
EYW
- DSM
2 stops11h 10m
United Airlines
Deal found 4/21![United Airlines logo]()
$294
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1611:00 am
DSM
- EYW
1 stop25h 07m
Multiple Airlines
Wed 5/2011:46 am
EYW
- DSM
2 stops35h 45m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$296
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:06 am
DSM
- EYW
2 stops10h 18m
American Airlines
Wed 10/282:57 pm
EYW
- DSM
2 stops7h 47m
American Airlines
Deal found 4/21![American Airlines logo]()
$300
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:53 pm
DSM
- EYW
1 stop15h 11m
Multiple Airlines
Thu 5/71:57 pm
EYW
- DSM
2 stops34h 00m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1611:00 am
DSM
- EYW
1 stop25h 07m
Allegiant Air
Wed 5/2010:22 am
EYW
- DSM
1 stop7h 13m
Allegiant Air
Deal found 4/23![Allegiant Air logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/57:18 pm
DSM
- EYW
1 stop17h 40m
Allegiant Air
Fri 6/124:35 pm
EYW
- DSM
1 stop7h 02m
Allegiant Air
Deal found 4/22![Allegiant Air logo]()
$312
This Delta deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1611:57 am
DSM
- EYW
1 stop6h 52m
Delta
Wed 5/207:30 am
EYW
- DSM
1 stop7h 07m
Delta
Deal found 4/19![Delta logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/211:00 am
DSM
- EYW
1 stop21h 06m
Multiple Airlines
Wed 5/610:39 am
EYW
- DSM
2 stops29h 36m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$322
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/107:10 am
DSM
- EYW
2 stops10h 39m
American Airlines
Tue 6/167:29 pm
EYW
- DSM
1 stop5h 41m
American Airlines
Deal found 4/21![American Airlines logo]()
$324
Best flights from Des Moines to Key WestDiscover carefully curated flight deals from Des Moines to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 24, 2026.
Discover carefully curated flight deals from Des Moines to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 24, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1611:00 am
DSM
- EYW
1 stop25h 07m
Multiple Airlines
Wed 5/2011:46 am
EYW
- DSM
2 stops35h 45m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$298
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/107:10 am
DSM
- EYW
2 stops10h 39m
American Airlines
Tue 6/1611:28 am
EYW
- DSM
2 stops10h 55m
American Airlines
Deal found 4/19![American Airlines logo]()
$383
This United Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:00 am
DSM
- EYW
1 stop8h 07m
United Airlines
Wed 7/84:00 pm
EYW
- DSM
1 stop6h 40m
United Airlines
Deal found 4/19![United Airlines logo]()
$523
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3011:51 am
DSM
- EYW
1 stop6h 49m
Delta
Sat 5/97:30 am
EYW
- DSM
1 stop7h 07m
Delta
Deal found 4/22![Delta logo]()
$534
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/512:56 pm
DSM
- EYW
2 stops45h 29m
Multiple Airlines
Fri 6/124:35 pm
EYW
- DSM
1 stop7h 02m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$425
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1411:11 am
DSM
- EYW
2 stops10h 25m
American Airlines
Mon 5/1811:56 am
EYW
- DSM
2 stops8h 37m
American Airlines
Deal found 4/23![American Airlines logo]()
$488
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:00 am
DSM
- EYW
1 stop9h 36m
American Airlines
Sat 5/307:29 pm
EYW
- DSM
1 stop5h 48m
American Airlines
Deal found 4/21![American Airlines logo]()
$490
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/118:00 am
DSM
- EYW
1 stop6h 07m
United Airlines
Fri 5/152:49 pm
EYW
- DSM
2 stops33h 55m
United Airlines
Deal found 4/21![United Airlines logo]()
$649
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1911:57 am
DSM
- EYW
1 stop6h 52m
Delta
Thu 5/216:19 pm
EYW
- DSM
1 stop5h 13m
Delta
Deal found 4/21![Delta logo]()
$667
Last-minute flights from Des Moines to Key WestDiscover last-minute flight deals from Des Moines to Key West. Data last updated April 24, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Key West. Data last updated April 24, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:53 pm
DSM
- EYW
1 stop15h 11m
Multiple Airlines
Thu 5/71:57 pm
EYW
- DSM
2 stops34h 00m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/211:00 am
DSM
- EYW
1 stop21h 06m
Multiple Airlines
Thu 5/71:57 pm
EYW
- DSM
2 stops34h 00m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/211:00 am
DSM
- EYW
1 stop21h 06m
Multiple Airlines
Wed 5/610:39 am
EYW
- DSM
2 stops29h 36m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$322
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1611:00 am
DSM
- EYW
1 stop25h 07m
Multiple Airlines
Wed 5/2011:46 am
EYW
- DSM
2 stops35h 45m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$296
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1611:00 am
DSM
- EYW
1 stop25h 07m
Allegiant Air
Wed 5/2010:22 am
EYW
- DSM
1 stop7h 13m
Allegiant Air
Deal found 4/23![Allegiant Air logo]()
$305
This Delta deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1611:57 am
DSM
- EYW
1 stop6h 52m
Delta
Wed 5/207:30 am
EYW
- DSM
1 stop7h 07m
Delta
Deal found 4/19![Delta logo]()
$319
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/168:56 am
DSM
- EYW
1 stop8h 20m
American Airlines
Wed 5/202:01 pm
EYW
- DSM
2 stops10h 48m
American Airlines
Deal found 4/20![American Airlines logo]()
$324
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:00 am
DSM
- EYW
1 stop8h 24m
American Airlines
Wed 5/277:29 pm
EYW
- DSM
1 stop5h 48m
American Airlines
Deal found 4/20![American Airlines logo]()
$289
One-way flights from Des Moines to Key WestSearch for one-way flight options from Des Moines to Key West. Find affordable one-way fares based on user searches. Data last updated April 24, 2026.
Search for one-way flight options from Des Moines to Key West. Find affordable one-way fares based on user searches. Data last updated April 24, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/219:43 am
DSM
- EYW
1 stop27h 18m
Allegiant Air
Deal found 4/20![Allegiant Air logo]()
$233
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/225:45 am
DSM
- EYW
1 stop6h 24m
Delta
Deal found 4/22![Delta logo]()
$334
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/225:00 am
DSM
- EYW
2 stops6h 57m
American Airlines
Deal found 4/22![American Airlines logo]()
$339
Find flight deals from Des Moines to Key West
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Key West (EYW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $289 (American Airlines) |
One-way from | $233 (Kiwi.com) |
Popular in | February |
Cheapest in | September |
Average price | $447 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2026.
Use the filters below to find and compare flights from Des Moines to Key West that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Sat 5/16
11:00 am-1:07 pm
1 stop25h 07m
Key West
Wed 5/20
11:46 am-10:31 pm
2 stops35h 45m
$298
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Wed 6/10
7:10 am-6:49 pm
2 stops10h 39m
Key West
Tue 6/16
11:28 am-9:23 pm
2 stops10h 55m
$383
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Fri 6/5
12:56 pm-11:25 am
2 stops45h 29m
Key West
Fri 6/12
4:35 pm-10:37 pm
1 stop7h 02m
$425
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Thu 5/14
11:11 am-10:36 pm
2 stops10h 25m
Key West
Mon 5/18
11:56 am-7:33 pm
2 stops8h 37m
$488
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Sat 5/23
6:00 am-4:36 pm
1 stop9h 36m
Key West
Sat 5/30
7:29 pm-12:17 am
1 stop5h 48m
$490
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Sat 7/4
6:00 am-3:07 pm
1 stop8h 07m
Key West
Wed 7/8
4:00 pm-9:40 pm
1 stop6h 40m
$523
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Thu 4/30
11:51 am-7:40 pm
1 stop6h 49m
Key West
Sat 5/9
7:30 am-1:37 pm
1 stop7h 07m
$534
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Mon 5/11
8:00 am-3:07 pm
1 stop6h 07m
Key West
Fri 5/15
2:49 pm-11:44 pm
2 stops33h 55m
$649
Quickest round-trip
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Tue 5/19
11:57 am-7:49 pm
1 stop6h 52m
Key West
Thu 5/21
6:19 pm-10:32 pm
1 stop5h 13m
$667
Cheapest one-way
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Thu 5/21
9:43 am-2:01 pm
1 stop27h 18m
$233
Showing 1-10 of 11 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Key West
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Key West in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Key West flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Key West flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Key West flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Key West flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Key West flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Key West
Have a flexible travel schedule? Discover the best time to fly to Key West from Des Moines with our price prediction graph.
DSM-EYW
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Key West
What is the cheapest month to book a flight from Des Moines to Key West?
Currently, September is the cheapest month in which you can book a flight from Des Moines to Key West (average of $289). Flying from Des Moines to Key West in February is currently the most expensive (average of $609). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Key West?
Reviews of airlines servicing Key West
Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated April 24, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAllegiant Air from Des Moines to Key West to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Food
7.2
Boarding
8.1
Crew
8.5
Entertainment
7.8
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Food
7.2
Boarding
8.1
Crew
8.5
Entertainment
7.8
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Food
7.2
Boarding
8.1
Crew
8.5
Entertainment
7.8
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Food
7.2
Boarding
8.1
Crew
8.5
Entertainment
7.8
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Food
7.2
Boarding
8.1
Crew
8.5
Entertainment
7.8
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Complete your trip
Complete your trip to Key West by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Des Moines to Key West, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Key West
Explore flights to Key West departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 24, 2026.
Des Moines and Key West flights
Browse other Des Moines and Key West flight options. Last updated on April 24, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on April 24, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 4 airlines flying from Des Moines to Key West
Discover the top 4 airlines that operate flights from Des Moines to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$76 | Average$174 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$268 | Average$475 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$268 | Average$408 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$288 | Average$447 | FlexibilityNo cancel fee | On-time69% |