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$227+ Cheap flights from Des Moines to Key West (DSM - EYW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/12. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
Jul 12 — Jul 191
Sat 7/12
Sat 7/19
1 adult, Economy
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Cheap flight deals from Des Moines to Key West

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Key West (EYW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 7, 2025.

Round-trip from

$269
(Delta)

Popular in

June

Cheapest in

April

Average price

$379
From Des Moines to Key West
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Highest demand for flights based on searches. 14% potential increase in price ($72 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($15 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Des Moines to Key West

Cheapest flights from Des Moines to Key West
Explore the most affordable flight options available from Des Moines to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 7, 2025.

This Mytrip deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/147:53 pmDSM - EYW
1 stop12h 40mAllegiant Air
Thu 8/218:53 amEYW - DSM
1 stop14h 26mAllegiant Air
Deal found 7/5$262
This Delta deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2311:23 amDSM - EYW
1 stop4h 49mDelta
Tue 8/267:00 amEYW - DSM
1 stop7h 27mDelta
Deal found 7/6$269
This American Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/55:10 amDSM - EYW
2 stops11h 36mAmerican Airlines
Tue 9/91:59 pmEYW - DSM
2 stops10h 14mAmerican Airlines
Deal found 7/7$279
This Mytrip deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/147:53 pmDSM - EYW
2 stops18h 29mMultiple Airlines
Thu 8/211:47 pmEYW - DSM
3 stops31h 54mMultiple Airlines
Deal found 7/5$402

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 7, 2025.
Use the filters below to find and compare flights from Des Moines to Key West that are best for you.

Fly from

Des Moines

Fly to

Key West

Route

Depart

Return

Price

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Thu 8/14

7:53 pm-9:33 am

1 stop12h 40m

Key West

Thu 8/21

8:53 am-10:19 pm

1 stop14h 26m

$262

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 8/23

11:23 am-5:12 pm

1 stop4h 49m

Key West

Tue 8/26

7:00 am-1:27 pm

1 stop7h 27m

$269

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 9/5

5:10 am-5:46 pm

2 stops11h 36m

Key West

Tue 9/9

1:59 pm-11:13 pm

2 stops10h 14m

$279

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Thu 8/14

7:53 pm-3:22 pm

2 stops18h 29m

Key West

Thu 8/21

1:47 pm-8:41 pm

3 stops31h 54m

$402

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 9/5

3:25 pm-2:11 pm

3 stops21h 46m

Key West

Tue 9/9

3:50 pm-4:13 pm

2 stops25h 23m

$691

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 9/12

11:25 am-8:07 pm

1 stop7h 42m

$227

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 9/12

8:00 am-3:14 pm

1 stop6h 14m

$295

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 9/12

8:00 am-2:11 pm

3 stops29h 11m

$543

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/7

Best time to book a flight from Des Moines to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Key West

How far ahead should I book a flight from Des Moines to Key West?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Key West. Price data was last updated on June 27, 2025.

The price you pay for your flight from Des Moines to Key West may vary depending on when you book. For the best chance of a lower fare, look to book 35 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Des Moines to Key West?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Key West (average of $328). Flying from Des Moines to Key West in March is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Key West

Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated July 7, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Des Moines to Key West to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,962 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,962 reviews
Delta
8.0
Very good
7,962 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,844 reviews
Delta
8.0
Very good
7,962 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,962 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Des Moines to Key West round-trip?

    Delta, at $269, was found to be the cheapest airline from Des Moines to Key West.Alternate airlines to your destination round-trip include American Airlines and United Airlines. Users have found that Delta is 39% cheaper than the other options available to this destination.

  • Can I find deals for flights from Des Moines to Key West that include hotel bookings?

    Yes. In addition to deals on Des Moines to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Key West.

  • Can I find deals for business class flights from Des Moines to Key West?

    Yes. Cheapflights offers flight deals from Des Moines to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Key West?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Key West (average of $328). Flying from Des Moines to Key West in March is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 4 airlines flying from Des Moines to Key West

Discover the top 4 airlines that operate flights from Des Moines to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 7, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$76Average$157FlexibilityNo cancel feeOn-time88%
DeltaCheapest$268Average$486FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$268Average$423FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$292Average$503FlexibilityNo cancel feeOn-time69%

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