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Key West

$289+ Cheap flights from Des Moines to Key West (DSM - EYW)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/2. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
Aug 19 — Aug 261
Wed 8/19
Wed 8/26
1 adult, Economy
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Cheap flight deals from Des Moines to Key West

Cheapest flights from Des Moines to Key West
Explore the most affordable flight options available from Des Moines to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 20, 2026.

This American Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/22:08 pm
DSM
-
EYW
1 stop6h 37m
American Airlines
Wed 12/94:10 pm
EYW
-
DSM
1 stop8h 19m
American Airlines
Deal found 7/16$289
This American Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/52:08 pm
DSM
-
EYW
1 stop6h 37m
American Airlines
Wed 12/94:10 pm
EYW
-
DSM
1 stop8h 19m
American Airlines
Deal found 7/19$309
This American Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3111:22 am
DSM
-
EYW
1 stop6h 27m
American Airlines
Sat 11/710:18 am
EYW
-
DSM
1 stop5h 28m
American Airlines
Deal found 7/19$329
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/512:59 pm
DSM
-
EYW
1 stop21h 21m
Allegiant Air
Thu 12/107:22 pm
EYW
-
DSM
1 stop19h 48m
Allegiant Air
Deal found 7/16$335
This American Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/86:40 am
DSM
-
EYW
1 stop8h 33m
American Airlines
Sat 12/124:53 pm
EYW
-
DSM
1 stop8h 32m
American Airlines
Deal found 7/19$338
This Kiwi.com deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2510:01 am
DSM
-
EYW
1 stop22h 38m
Multiple Airlines
Wed 12/210:45 am
EYW
-
DSM
2 stops31h 01m
Multiple Airlines
Deal found 7/19$339
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/512:59 pm
DSM
-
EYW
1 stop21h 21m
Allegiant Air
Fri 12/113:58 pm
EYW
-
DSM
1 stop6h 35m
Allegiant Air
Deal found 7/16$350
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/308:30 am
DSM
-
EYW
1 stop4h 46m
Multiple Airlines
Wed 12/910:45 am
EYW
-
DSM
2 stops31h 01m
Multiple Airlines
Deal found 7/16$368
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/308:30 am
DSM
-
EYW
1 stop4h 46m
Allegiant Air
Thu 12/107:22 pm
EYW
-
DSM
1 stop19h 48m
Allegiant Air
Deal found 7/16$372
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/512:59 pm
DSM
-
EYW
1 stop21h 21m
Allegiant Air
Mon 12/73:58 pm
EYW
-
DSM
1 stop6h 35m
Allegiant Air
Deal found 7/16$376

Find flight deals from Des Moines to Key West

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Key West (EYW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 20, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$289
(American Airlines)

Popular in

February

Cheapest in

September

Average price

$378
Provider with most accurate pricing for Des Moines-Key West flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Key West flights.
Search Deals
From Des Moines to Key West
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($24 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 20, 2026.
Use the filters below to find and compare flights from Des Moines to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 8/18

5:40 am-1:00 pm

1 stop6h 20m

Key West

Mon 8/24

6:15 pm-10:37 pm

1 stop5h 22m

$309

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 12/8

6:40 am-4:13 pm

1 stop8h 33m

Key West

Sat 12/12

4:53 pm-12:25 am

1 stop8h 32m

$338

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 11/14

9:27 am-5:56 pm

2 stops7h 29m

Key West

Tue 11/17

6:31 pm-12:18 am

1 stop6h 47m

$377

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 12/1

8:00 am-3:06 pm

1 stop6h 06m

Key West

Wed 12/9

2:30 pm-11:40 pm

2 stops10h 10m

$456

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Mon 11/30

11:04 am-7:43 pm

1 stop7h 39m

Key West

Wed 12/9

6:00 pm-10:29 pm

1 stop5h 29m

$464

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 12/4

6:15 am-3:06 pm

1 stop7h 51m

Key West

Thu 12/10

2:30 pm-11:40 pm

2 stops10h 10m

$528

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 10/7

7:01 am-6:49 pm

2 stops10h 48m

Key West

Mon 10/12

7:19 pm-11:58 pm

1 stop5h 39m

$552

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 12/5

8:00 am-1:02 pm

3 stops28h 02m

Key West

Wed 12/9

2:30 pm-11:40 pm

2 stops10h 10m

$584

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/19

Sorted by cheapest first

Compare providers for flights from Des Moines to Key West

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Key West in July.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Key West flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Key West flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Key West flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Key West flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Key West flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Key West

What is the cheapest month to book a flight from Des Moines to Key West?

Currently, September is the cheapest month in which you can book a flight from Des Moines to Key West (average of $323). Flying from Des Moines to Key West in February is currently the most expensive (average of $609). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Des Moines to Key West?

Reviews of airlines servicing Key West

Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated July 20, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAmerican Airlines from Des Moines to Key West to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.8
Good
8,476 reviews

Comfort

7.8

Overall

7.8

Boarding

8.1

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
4.0
Okay

Joel,May 2026

ATL - JAX

The flight was delivered 50 minutes and taxing took what felt like 20 minutes to takeoff.
Delta
7.8
Good
8,476 reviews
Delta
7.8
Good
8,476 reviews

Comfort

7.8

Overall

7.8

Boarding

8.1

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
4.0
Okay

Joel,May 2026

ATL - JAX

The flight was delivered 50 minutes and taxing took what felt like 20 minutes to takeoff.
United Airlines
7.4
Good
10,013 reviews
Delta
7.8
Good
8,476 reviews

Comfort

7.8

Overall

7.8

Boarding

8.1

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
4.0
Okay

Joel,May 2026

ATL - JAX

The flight was delivered 50 minutes and taxing took what felt like 20 minutes to takeoff.
American Airlines
7.1
Good
11,826 reviews
Delta
7.8
Good
8,476 reviews

Comfort

7.8

Overall

7.8

Boarding

8.1

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
4.0
Okay

Joel,May 2026

ATL - JAX

The flight was delivered 50 minutes and taxing took what felt like 20 minutes to takeoff.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Key West?

    Departing from Des Moines to Key West will take you 6h 06m. The distance between Des Moines and Key West is about 1357 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Des Moines to Key West round-trip?

    United Airlines, at $268, was found to be the cheapest airline from Des Moines to Key West.Alternate airlines to your destination round-trip include Delta and American Airlines. Users have found that United Airlines is 44% cheaper than the other options available to this destination.

  • Can I find deals for flights from Des Moines to Key West that include hotel bookings?

    Yes. In addition to deals on Des Moines to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Key West.

  • Can I find deals for business class flights from Des Moines to Key West?

    Yes. Cheapflights offers flight deals from Des Moines to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Key West?

    Currently, September is the cheapest month in which you can book a flight from Des Moines to Key West (average of $323). Flying from Des Moines to Key West in February is currently the most expensive (average of $609). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Des Moines to Key West

Discover the top 3 airlines that operate flights from Des Moines to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 20, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$268Average$454FlexibilityNo cancel feeOn-time69%
DeltaCheapest$268Average$488FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$279Average$500FlexibilityNo cancel feeOn-time71%

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