$155+ Cheap flights from Des Moines to Key West (DSM - EYW)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/18. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
Oct 13 — Oct 201
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Des Moines to Key West with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Key West
Cheapest
Best
Last-minute
One-way
Cheapest flights from Des Moines to Key WestExplore the most affordable flight options available from Des Moines to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 13, 2026.
Explore the most affordable flight options available from Des Moines to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 13, 2026.
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/511:35 am -
1 stop7h 27m
Wed 12/96:06 pm -
1 stop5h 32m
Deal found 9/9![Delta logo]()
$299
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/411:35 am -
1 stop7h 27m
Wed 12/96:06 pm -
1 stop5h 32m
Deal found 9/13![Delta logo]()
$339
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/512:59 pm -
1 stop21h 21m
Wed 12/94:40 pm -
2 stops25h 06m
Deal found 9/10![Multiple Airlines logo]()
$340
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:00 am -
1 stop5h 35m
Sat 10/247:19 pm -
1 stop5h 39m
Deal found 9/10![American Airlines logo]()
$348
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1111:35 am -
1 stop4h 36m
Tue 12/156:06 pm -
1 stop5h 32m
Deal found 9/9![Delta logo]()
$359
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/52:19 pm -
1 stop21h 17m
Fri 10/910:20 pm -
1 stop18h 06m
Deal found 9/12![Multiple Airlines logo]()
$362
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/42:50 pm -
1 stop25h 46m
Wed 12/910:45 am -
2 stops31h 01m
Deal found 9/13![Multiple Airlines logo]()
$363
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:23 am -
1 stop7h 53m
Wed 12/91:14 pm -
1 stop6h 42m
Deal found 9/11![American Airlines logo]()
$368
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/119:25 am -
1 stop6h 07m
Tue 12/155:50 pm -
1 stop6h 36m
Deal found 9/9![American Airlines logo]()
$369
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/39:00 am -
1 stop28h 13m
Sat 10/1010:04 am -
2 stops29h 38m
Deal found 9/10![Multiple Airlines logo]()
$377
Best flights from Des Moines to Key WestDiscover carefully curated flight deals from Des Moines to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 13, 2026.
Discover carefully curated flight deals from Des Moines to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 13, 2026.
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/411:35 am -
1 stop7h 27m
Wed 12/96:06 pm -
1 stop5h 32m
Deal found 9/13![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:00 am -
1 stop8h 24m
Sat 10/104:20 pm -
1 stop6h 03m
Deal found 9/10![United Airlines logo]()
$432
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/77:12 am -
2 stops11h 21m
Mon 10/127:19 pm -
1 stop5h 39m
Deal found 9/13![American Airlines logo]()
$733
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:45 am -
1 stop6h 08m
Wed 9/307:40 am -
1 stop7h 09m
Deal found 9/11![Delta logo]()
$558
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:00 am -
1 stop8h 24m
Wed 10/282:51 pm -
2 stops27h 36m
Deal found 9/12![United Airlines logo]()
$700
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/51:15 pm -
1 stop20h 56m
Wed 12/94:10 pm -
1 stop6h 15m
Deal found 9/10![United Airlines logo]()
$732
Last-minute flights from Des Moines to Key WestDiscover last-minute flight deals from Des Moines to Key West. Data last updated September 13, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Key West. Data last updated September 13, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:00 am -
2 stops12h 17m
Wed 9/302:15 pm -
1 stop6h 33m
Deal found 9/11![American Airlines logo]()
$442
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/39:00 am -
1 stop28h 13m
Sat 10/1010:04 am -
2 stops29h 38m
Deal found 9/10![Multiple Airlines logo]()
$377
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:00 am -
1 stop8h 24m
Sat 10/104:20 pm -
1 stop6h 03m
Deal found 9/10![United Airlines logo]()
$432
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/52:19 pm -
1 stop21h 17m
Fri 10/910:20 pm -
1 stop18h 06m
Deal found 9/12![Multiple Airlines logo]()
$362
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:00 am -
1 stop5h 35m
Tue 10/132:49 pm -
1 stop8h 56m
Deal found 9/9![American Airlines logo]()
$431
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1911:22 am -
1 stop6h 27m
Sat 10/247:19 pm -
1 stop5h 39m
Deal found 9/10![American Airlines logo]()
$368
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:00 am -
1 stop5h 35m
Sat 10/247:19 pm -
1 stop5h 39m
Deal found 9/10![American Airlines logo]()
$348
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:12 am -
2 stops10h 37m
Tue 10/272:15 pm -
1 stop8h 09m
Deal found 9/8![American Airlines logo]()
$436
One-way flights from Des Moines to Key WestSearch for one-way flight options from Des Moines to Key West. Find affordable one-way fares based on user searches. Data last updated September 13, 2026.
Search for one-way flight options from Des Moines to Key West. Find affordable one-way fares based on user searches. Data last updated September 13, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/188:43 am -
2 stops28h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Multiple Airlines logo]()
$155
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:25 am -
2 stops29h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Multiple Airlines logo]()
$164
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/810:55 am -
1 stop27h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Allegiant Air logo]()
$189
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/198:00 am -
1 stop5h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Allegiant Air logo]()
$222
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/179:00 am -
1 stop24h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Multiple Airlines logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/711:05 am -
2 stops27h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Multiple Airlines logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/81:57 pm -
2 stops24h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Multiple Airlines logo]()
$311
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/187:08 am -
1 stop8h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![American Airlines logo]()
$329
Find flight deals from Des Moines to Key West
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Key West (EYW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $299 (Delta) |
One-way from | $155 (Kiwi.com) |
Popular in | February |
Cheapest in | July |
Average price | $458 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 13, 2026.
Use the filters below to find and compare flights from Des Moines to Key West that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesKey West
DSM Des Moines - EYW Key West
DSMEYW
Des Moines
Sun 10/18
8:43 am-2:04 pm
2 stops28h 21m
Key West
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$155
Des MoinesKey West
DSM Des Moines - EYW Key West
DSMEYW
Des Moines
Fri 1/8
10:55 am-3:17 pm
1 stop27h 22m
Key West
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$189
Des MoinesKey West
DSM Des Moines - EYW Key West
DSMEYW
Des Moines
Sat 10/17
9:00 am-10:19 am
1 stop24h 19m
Key West
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$250
Des MoinesKey West
DSM Des Moines - EYW Key West
DSMEYW
Des Moines
Thu 1/7
10:07 pm-11:39 am
3 stops36h 32m
Key West
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$301
Quickest round-trip
Des MoinesKey West
DSM Des Moines - EYW Key West
DSMEYW
Des Moines
Thu 1/7
9:37 am-5:10 pm
1 stop6h 33m
Key West
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$329
Des MoinesKey West
DSM Des Moines - EYW Key West
DSMEYW
Des Moines
Fri 12/4
11:35 am-8:02 pm
1 stop7h 27m
Key West
Wed 12/9
6:06 pm-10:38 pm
1 stop5h 32m
$339
Des MoinesKey West
DSM Des Moines - EYW Key West
DSMEYW
Des Moines
Fri 1/8
3:34 pm-11:26 am
3 stops42h 52m
Key West
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$341
Des MoinesKey West
DSM Des Moines - EYW Key West
DSMEYW
Des Moines
Sat 10/17
7:29 am-12:08 pm
2 stops27h 39m
Key West
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$408
Des MoinesKey West
DSM Des Moines - EYW Key West
DSMEYW
Des Moines
Sat 10/3
6:00 am-3:24 pm
1 stop8h 24m
Key West
Sat 10/10
4:20 pm-9:23 pm
1 stop6h 03m
$432
Des MoinesKey West
DSM Des Moines - EYW Key West
DSMEYW
Des Moines
Sat 9/26
5:45 am-12:53 pm
1 stop6h 08m
Key West
Wed 9/30
7:40 am-1:49 pm
1 stop7h 09m
$558
Showing 1-10 of 13 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Key West
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Key West in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Key West flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Key West flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Key West flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Key West flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Key West flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Key West
Have a flexible travel schedule? Discover the best time to fly to Key West from Des Moines with our price prediction graph.
DSM-EYW
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Key West
Reviews of airlines servicing Key West
Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated September 13, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAmerican Airlines from Des Moines to Key West to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.5
Overall
7.8
Food
7.2
Entertainment
7.8
Comfort
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Boarding
8.1
Crew
8.5
Overall
7.8
Food
7.2
Entertainment
7.8
Comfort
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Boarding
8.1
Crew
8.5
Overall
7.8
Food
7.2
Entertainment
7.8
Comfort
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Boarding
8.1
Crew
8.5
Overall
7.8
Food
7.2
Entertainment
7.8
Comfort
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Key West flight routes
Other flight options
Other flights from Des Moines
Popular flights
Alternative routes for Des Moines to Key West
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Key West by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Des Moines to Key West by cabin class
Find flights from Des Moines to Key West, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Key West
Explore flights to Key West departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 13, 2026.
Des Moines and Key West flights
Browse other Des Moines and Key West flight options. Last updated on September 13, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on September 13, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Des Moines to Key West
Discover the top 3 airlines that operate flights from Des Moines to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$268 | Average$488 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$288 | Average$458 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$289 | Average$510 | FlexibilityNo cancel fee | On-time71% |