$95+ Cheap flights from Des Moines to Santa Ana, CA (DSM - SNA)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/18. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SNA
Oct 19 — Oct 261
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Santa Ana with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Des Moines to Santa Ana J. Wayne/Orange Cnty are usually found in January or September, booked 33 days in advance, depart on a Monday or Saturday and return on a Monday
Cheap flight deals from Des Moines to Santa Ana
Cheapest
Best
Last-minute
One-way
Cheapest flights from Des Moines to Santa AnaExplore the most affordable flight options available from Des Moines to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 19, 2026.
Explore the most affordable flight options available from Des Moines to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 19, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/252:18 pm -
Nonstop3h 38m
Thu 10/294:46 pm -
Nonstop3h 15m
Deal found 9/17![Allegiant Air logo]()
$199
This CheapOair deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/52:22 pm -
Nonstop3h 38m
Sun 11/84:10 pm -
Nonstop3h 17m
Deal found 9/16![Allegiant Air logo]()
$231
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:31 pm -
1 stop19h 32m
Thu 10/19:28 am -
Nonstop3h 15m
Deal found 9/15![Multiple Airlines logo]()
$241
This CheapOair deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:18 pm -
Nonstop3h 38m
Sun 11/14:46 pm -
Nonstop3h 15m
Deal found 9/16![Allegiant Air logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:31 pm -
1 stop19h 32m
Thu 10/84:46 pm -
Nonstop3h 15m
Deal found 9/16![Multiple Airlines logo]()
$269
This CheapOair deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/181:38 pm -
Nonstop3h 38m
Sun 10/254:46 pm -
Nonstop3h 15m
Deal found 9/18![Allegiant Air logo]()
$277
This Cheapflightsfares deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/222:18 pm -
Nonstop3h 38m
Sun 10/254:46 pm -
Nonstop3h 15m
Deal found 9/14![Allegiant Air logo]()
$279
Best flights from Des Moines to Santa AnaDiscover carefully curated flight deals from Des Moines to Santa Ana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 19, 2026.
Discover carefully curated flight deals from Des Moines to Santa Ana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 19, 2026.
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:00 am -
1 stop7h 02m
Tue 10/271:09 pm -
1 stop5h 27m
Deal found 9/15![United Airlines logo]()
$293
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:55 am -
2 stops12h 27m
Tue 10/276:02 pm -
2 stops14h 09m
Deal found 9/15![Delta logo]()
$303
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/37:00 am -
1 stop5h 05m
Fri 11/62:40 pm -
1 stop5h 25m
Deal found 9/18![Southwest logo]()
$372
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/54:00 pm -
2 stops7h 55m
Mon 2/87:15 am -
2 stops12h 09m
Deal found 9/17![Delta logo]()
$365
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2910:57 am -
2 stops13h 33m
Sun 11/111:32 am -
1 stop9h 01m
Deal found 9/16![Delta logo]()
$401
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/265:12 pm -
1 stop6h 48m
Fri 10/308:00 pm -
2 stops12h 32m
Deal found 9/18![United Airlines logo]()
$487
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/156:25 am -
2 stops8h 40m
Mon 1/1811:00 am -
2 stops8h 20m
Deal found 9/17![Southwest logo]()
$497
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/22:46 pm -
2 stops9h 18m
Tue 10/136:02 pm -
2 stops14h 09m
Deal found 9/15![Delta logo]()
$455
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/215:12 pm -
1 stop6h 47m
Mon 12/286:48 am -
1 stop7h 28m
Deal found 9/17![United Airlines logo]()
$535
Last-minute flights from Des Moines to Santa AnaDiscover last-minute flight deals from Des Moines to Santa Ana. Data last updated September 19, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Santa Ana. Data last updated September 19, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:31 pm -
1 stop19h 32m
Thu 10/19:28 am -
Nonstop3h 15m
Deal found 9/15![Multiple Airlines logo]()
$241
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:31 pm -
1 stop19h 32m
Thu 10/84:46 pm -
Nonstop3h 15m
Deal found 9/16![Multiple Airlines logo]()
$269
This CheapOair deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/181:38 pm -
Nonstop3h 38m
Sun 10/254:46 pm -
Nonstop3h 15m
Deal found 9/18![Allegiant Air logo]()
$277
This Cheapflightsfares deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/222:18 pm -
Nonstop3h 38m
Sun 10/254:46 pm -
Nonstop3h 15m
Deal found 9/14![Allegiant Air logo]()
$279
This Cheapflightsfares deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/252:18 pm -
Nonstop3h 38m
Thu 10/294:46 pm -
Nonstop3h 15m
Deal found 9/17![Allegiant Air logo]()
$199
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/252:18 pm -
Nonstop3h 38m
Thu 10/292:47 pm -
1 stop19h 50m
Deal found 9/17![Multiple Airlines logo]()
$286
This CheapOair deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:18 pm -
Nonstop3h 38m
Sun 11/14:46 pm -
Nonstop3h 15m
Deal found 9/16![Allegiant Air logo]()
$261
One-way flights from Des Moines to Santa AnaSearch for one-way flight options from Des Moines to Santa Ana. Find affordable one-way fares based on user searches. Data last updated September 19, 2026.
Search for one-way flight options from Des Moines to Santa Ana. Find affordable one-way fares based on user searches. Data last updated September 19, 2026.
This CheapOair deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/181:38 pm -
Nonstop3h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Allegiant Air logo]()
$95
This Booking.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/111:38 pm -
Nonstop3h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Allegiant Air logo]()
$109
This Cheapflightsfares deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/252:50 pm -
Nonstop3h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Allegiant Air logo]()
$117
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/269:11 pm -
1 stop19h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Multiple Airlines logo]()
$124
This CheapOair deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/252:18 pm -
Nonstop3h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Allegiant Air logo]()
$126
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/173:02 pm -
1 stop8h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![United Airlines logo]()
$147
This CheapOair deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:18 pm -
Nonstop3h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Allegiant Air logo]()
$159
Find flight deals from Des Moines to Santa Ana
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Santa Ana (SNA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 19, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $199 (Cheapflightsfares) |
One-way from | $95 (CheapOair) |
Popular in | March |
Cheapest in | January |
Average price | $189 |
Good round-trip deal | $207 or less |
Good one-way deal | $109 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 19, 2026.
Use the filters below to find and compare flights from Des Moines to Santa Ana that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Des MoinesSanta Ana
DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty
DSMSNA
Des Moines
Sun 10/25
2:18 pm-3:56 pm
Nonstop3h 38m
Santa Ana J. Wayne/Orange Cnty
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$137
Des MoinesSanta Ana
DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty
DSMSNA
Des Moines
Sat 10/17
3:02 pm-9:51 pm
1 stop8h 49m
Santa Ana J. Wayne/Orange Cnty
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$147
Des MoinesSanta Ana
DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty
DSMSNA
Des Moines
Sat 10/17
2:30 pm-5:45 pm
1 stop5h 15m
Santa Ana J. Wayne/Orange Cnty
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$147
Des MoinesSanta Ana
DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty
DSMSNA
Des Moines
Thu 10/29
10:57 am-10:30 pm
2 stops13h 33m
Santa Ana J. Wayne/Orange Cnty
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$173
Des MoinesSanta Ana
DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty
DSMSNA
Des Moines
Fri 1/15
5:45 am-12:56 pm
1 stop9h 11m
Santa Ana J. Wayne/Orange Cnty
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$188
Des MoinesSanta Ana
DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty
DSMSNA
Des Moines
Sun 10/25
1:57 pm-7:14 pm
1 stop7h 17m
Santa Ana J. Wayne/Orange Cnty
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$205
Des MoinesSanta Ana
DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty
DSMSNA
Des Moines
Mon 10/19
5:45 am-9:29 am
1 stop5h 44m
Santa Ana J. Wayne/Orange Cnty
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$213
Des MoinesSanta Ana
DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty
DSMSNA
Des Moines
Mon 11/2
5:09 pm-10:00 pm
1 stop6h 51m
Santa Ana J. Wayne/Orange Cnty
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$213
Des MoinesSanta Ana
DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty
DSMSNA
Des Moines
Thu 10/29
8:00 am-5:33 pm
2 stops11h 33m
Santa Ana J. Wayne/Orange Cnty
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$218
Des MoinesSanta Ana
DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty
DSMSNA
Des Moines
Wed 10/21
6:00 am-11:02 am
1 stop7h 02m
Santa Ana J. Wayne/Orange Cnty
Tue 10/27
1:09 pm-8:36 pm
1 stop5h 27m
$293
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Santa Ana
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Santa Ana in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*1 star | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Santa Ana, California flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Santa Ana, California flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Santa Ana, California flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Santa Ana, California flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Santa Ana, California flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Santa Ana
Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Des Moines with our price prediction graph.
DSM-SNA
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Santa Ana
How far ahead should I book a flight from Des Moines to Santa Ana, California?
To ensure you get the cheapest price possible for a flight from Des Moines to Santa Ana, California, you should look to book at least 23 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
What is the cheapest month to book a flight from Des Moines to Santa Ana, California?
Currently, January is the cheapest month in which you can book a flight from Des Moines to Santa Ana, California (average of $164). Flying from Des Moines to Santa Ana, California in March is currently the most expensive (average of $586). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Santa Ana, California?
Airfare is typical for this route at the moment.
Des Moines to Santa Ana, California flights typically cost between $174 and $322 in October.The cheapest round-trip price found within the last 5 days was $199 on Allegiant Air (Oct 25-Oct 29).
Reviews of airlines servicing Santa Ana
Get insights into the airlines that provide service to Santa Ana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Ana. Reviews last updated September 19, 2026.
Read through reviews of airlines operating flights from Des Moines to Santa Ana, such as Southwest,United Airlines, andAllegiant Air. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Overall
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Overall
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Overall
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Overall
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Santa Ana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Santa Ana?
Book flights to Santa Ana if you plan to visit one of these locationsTustin
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Des Moines and Santa Ana flights
Browse other Des Moines and Santa Ana flight options. Last updated on September 19, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on September 19, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santa Ana
Explore flights to Santa Ana departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 19, 2026.
Top 4 airlines flying from Des Moines to Santa Ana
Discover the top 4 airlines that operate flights from Des Moines to Santa Ana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 19, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$124 | Average$226 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$268 | Average$416 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$294 | Average$405 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$341 | Average$476 | FlexibilityNo cancel fee | On-time63% |