$65+ Cheap flights from Des Moines to Santa Ana, CA (DSM - SNA)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/29. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SNA
Sep 3 — Sep 101
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Santa Ana with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Des Moines to Santa Ana J. Wayne/Orange Cnty are usually found in January or September, booked 30 days in advance, depart on a Monday or Saturday and return on a Monday
Cheap flight deals from Des Moines to Santa Ana
Cheapest
Best
Last-minute
One-way
Cheapest flights from Des Moines to Santa AnaExplore the most affordable flight options available from Des Moines to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 4, 2026.
Explore the most affordable flight options available from Des Moines to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 4, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:18 pm
DSM
- SNA
Nonstop3h 38m
Allegiant Air
Sun 11/14:46 pm
SNA
- DSM
Nonstop3h 15m
Allegiant Air
Deal found 8/4![Allegiant Air logo]()
$140
This CheapOair deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2010:00 am
DSM
- SNA
Nonstop3h 37m
Allegiant Air
Sun 9/2712:27 pm
SNA
- DSM
Nonstop3h 17m
Allegiant Air
Deal found 8/1![Allegiant Air logo]()
$143
This Cheapflightsfares deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:00 am
DSM
- SNA
Nonstop3h 38m
Allegiant Air
Sun 10/49:28 am
SNA
- DSM
Nonstop3h 15m
Allegiant Air
Deal found 8/1![Allegiant Air logo]()
$148
This CheapOair deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2710:00 am
DSM
- SNA
Nonstop3h 36m
Allegiant Air
Sun 8/3012:26 pm
SNA
- DSM
Nonstop3h 17m
Allegiant Air
Deal found 8/2![Allegiant Air logo]()
$170
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/181:38 pm
DSM
- SNA
Nonstop3h 38m
Allegiant Air
Thu 10/224:46 pm
SNA
- DSM
Nonstop3h 15m
Allegiant Air
Deal found 7/30![Allegiant Air logo]()
$175
Best flights from Des Moines to Santa AnaDiscover carefully curated flight deals from Des Moines to Santa Ana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 4, 2026.
Discover carefully curated flight deals from Des Moines to Santa Ana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 4, 2026.
This Southwest deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/213:50 pm
DSM
- SNA
2 stops8h 20m
Southwest
Thu 8/2711:30 am
SNA
- DSM
2 stops7h 45m
Southwest
Deal found 7/31![Southwest logo]()
$413
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/195:45 am
DSM
- SNA
1 stop5h 44m
United Airlines
Tue 10/206:45 am
SNA
- DSM
1 stop9h 03m
United Airlines
Deal found 7/30![United Airlines logo]()
$445
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:45 pm
DSM
- SNA
2 stops9h 15m
Delta
Thu 8/271:00 pm
SNA
- DSM
1 stop5h 59m
Delta
Deal found 7/31![Delta logo]()
$446
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:20 am
DSM
- SNA
2 stops8h 40m
Southwest
Sun 11/112:30 pm
SNA
- DSM
2 stops7h 30m
Southwest
Deal found 8/2![Southwest logo]()
$441
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:23 pm
DSM
- SNA
1 stop7h 28m
United Airlines
Thu 10/14:15 pm
SNA
- DSM
1 stop5h 33m
United Airlines
Deal found 7/31![United Airlines logo]()
$475
This United Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:21 pm
DSM
- SNA
1 stop5h 23m
United Airlines
Mon 9/144:14 pm
SNA
- DSM
1 stop5h 19m
United Airlines
Deal found 8/3![United Airlines logo]()
$478
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/273:50 pm
DSM
- SNA
2 stops8h 20m
Southwest
Sun 8/3012:15 pm
SNA
- DSM
2 stops7h 15m
Southwest
Deal found 8/2![Southwest logo]()
$484
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/195:45 am
DSM
- SNA
1 stop5h 44m
United Airlines
Mon 10/198:00 pm
SNA
- DSM
2 stops12h 31m
United Airlines
Deal found 7/30![United Airlines logo]()
$483
This Southwest deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:15 am
DSM
- SNA
2 stops8h 20m
Southwest
Sat 8/2210:40 am
SNA
- DSM
2 stops8h 05m
Southwest
Deal found 7/31![Southwest logo]()
$491
This United Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/125:21 pm
DSM
- SNA
1 stop5h 23m
United Airlines
Sun 9/134:14 pm
SNA
- DSM
1 stop5h 19m
United Airlines
Deal found 8/3![United Airlines logo]()
$497
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/215:45 am
DSM
- SNA
1 stop5h 22m
United Airlines
Fri 9/258:00 pm
SNA
- DSM
2 stops12h 31m
United Airlines
Deal found 7/31![United Airlines logo]()
$498
Last-minute flights from Des Moines to Santa AnaDiscover last-minute flight deals from Des Moines to Santa Ana. Data last updated August 4, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Santa Ana. Data last updated August 4, 2026 and is based on user searches.
This Cheapflightsfares deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/167:00 am
DSM
- SNA
Nonstop3h 42m
Allegiant Air
Thu 8/2712:26 pm
SNA
- DSM
Nonstop3h 17m
Allegiant Air
Deal found 8/1![Allegiant Air logo]()
$213
This Cheapflightsfares deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2010:00 am
DSM
- SNA
Nonstop3h 36m
Allegiant Air
Thu 8/2712:26 pm
SNA
- DSM
Nonstop3h 17m
Allegiant Air
Deal found 7/31![Allegiant Air logo]()
$189
This CheapOair deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2010:00 am
DSM
- SNA
Nonstop3h 36m
Allegiant Air
Sun 8/2312:26 pm
SNA
- DSM
Nonstop3h 17m
Allegiant Air
Deal found 7/29![Allegiant Air logo]()
$233
This CheapOair deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2710:00 am
DSM
- SNA
Nonstop3h 36m
Allegiant Air
Sun 8/3012:26 pm
SNA
- DSM
Nonstop3h 17m
Allegiant Air
Deal found 8/2![Allegiant Air logo]()
$170
This Cheapflightsfares deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1710:00 am
DSM
- SNA
Nonstop3h 37m
Allegiant Air
Thu 9/2412:27 pm
SNA
- DSM
Nonstop3h 17m
Allegiant Air
Deal found 7/30![Allegiant Air logo]()
$206
This CheapOair deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2010:00 am
DSM
- SNA
Nonstop3h 37m
Allegiant Air
Sun 9/2712:27 pm
SNA
- DSM
Nonstop3h 17m
Allegiant Air
Deal found 8/1![Allegiant Air logo]()
$143
One-way flights from Des Moines to Santa AnaSearch for one-way flight options from Des Moines to Santa Ana. Find affordable one-way fares based on user searches. Data last updated August 4, 2026.
Search for one-way flight options from Des Moines to Santa Ana. Find affordable one-way fares based on user searches. Data last updated August 4, 2026.
This CheapOair deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:18 pm
DSM
- SNA
Nonstop3h 38m
Allegiant Air
Deal found 7/31![Allegiant Air logo]()
$65
This CheapOair deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2710:00 am
DSM
- SNA
Nonstop3h 37m
Allegiant Air
Deal found 7/29![Allegiant Air logo]()
$89
This Cheapflightsfares deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1010:00 am
DSM
- SNA
Nonstop3h 37m
Allegiant Air
Deal found 8/1![Allegiant Air logo]()
$108
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/610:00 am
DSM
- SNA
Nonstop3h 37m
Allegiant Air
Deal found 8/2![Allegiant Air logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1011:29 am
DSM
- SNA
1 stop25h 36m
Frontier
Deal found 8/1![Frontier logo]()
$132
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/119:31 pm
DSM
- SNA
1 stop22h 09m
Multiple Airlines
Deal found 8/1![Multiple Airlines logo]()
$142
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/279:56 pm
DSM
- SNA
1 stop21h 19m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$147
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1010:06 pm
DSM
- SNA
1 stop19h 17m
Multiple Airlines
Deal found 8/1![Multiple Airlines logo]()
$148
Find flight deals from Des Moines to Santa Ana
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Santa Ana (SNA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $120 (Travelocity) |
One-way from | $65 (CheapOair) |
Popular in | March |
Cheapest in | January |
Average price | $374 |
Good round-trip deal | $173 or less |
Good one-way deal | $176 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 4, 2026.
Use the filters below to find and compare flights from Des Moines to Santa Ana that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSanta Ana
DSM - SNA
DSMSNA
Des Moines
Fri 8/21
3:50 pm-10:10 pm
2 stops8h 20m
Santa Ana J. Wayne/Orange Cnty
Thu 8/27
11:30 am-9:15 pm
2 stops7h 45m
$413
Des MoinesSanta Ana
DSM - SNA
DSMSNA
Des Moines
Thu 10/29
6:20 am-1:00 pm
2 stops8h 40m
Santa Ana J. Wayne/Orange Cnty
Sun 11/1
12:30 pm-10:00 pm
2 stops7h 30m
$441
Des MoinesSanta Ana
DSM - SNA
DSMSNA
Des Moines
Mon 10/19
5:45 am-9:29 am
1 stop5h 44m
Santa Ana J. Wayne/Orange Cnty
Tue 10/20
6:45 am-5:48 pm
1 stop9h 03m
$445
Des MoinesSanta Ana
DSM - SNA
DSMSNA
Des Moines
Fri 8/21
2:45 pm-10:00 pm
2 stops9h 15m
Santa Ana J. Wayne/Orange Cnty
Thu 8/27
1:00 pm-8:59 pm
1 stop5h 59m
$446
Des MoinesSanta Ana
DSM - SNA
DSMSNA
Des Moines
Sat 9/19
1:23 pm-6:51 pm
1 stop7h 28m
Santa Ana J. Wayne/Orange Cnty
Thu 10/1
4:15 pm-11:48 pm
1 stop5h 33m
$475
Quickest round-trip
Des MoinesSanta Ana
DSM - SNA
DSMSNA
Des Moines
Fri 9/11
5:21 pm-8:44 pm
1 stop5h 23m
Santa Ana J. Wayne/Orange Cnty
Mon 9/14
4:14 pm-11:33 pm
1 stop5h 19m
$478
Des MoinesSanta Ana
DSM - SNA
DSMSNA
Des Moines
Mon 10/19
5:45 am-9:29 am
1 stop5h 44m
Santa Ana J. Wayne/Orange Cnty
Mon 10/19
8:00 pm-10:31 am
2 stops12h 31m
$483
Des MoinesSanta Ana
DSM - SNA
DSMSNA
Des Moines
Thu 8/27
3:50 pm-10:10 pm
2 stops8h 20m
Santa Ana J. Wayne/Orange Cnty
Sun 8/30
12:15 pm-9:30 pm
2 stops7h 15m
$484
Des MoinesSanta Ana
DSM - SNA
DSMSNA
Des Moines
Tue 8/18
7:15 am-1:35 pm
2 stops8h 20m
Santa Ana J. Wayne/Orange Cnty
Sat 8/22
10:40 am-8:45 pm
2 stops8h 05m
$491
Des MoinesSanta Ana
DSM - SNA
DSMSNA
Des Moines
Sat 9/12
5:21 pm-8:44 pm
1 stop5h 23m
Santa Ana J. Wayne/Orange Cnty
Sun 9/13
4:14 pm-11:33 pm
1 stop5h 19m
$497
Showing 1-10 of 22 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Santa Ana
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Santa Ana in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*1 star | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Santa Ana, California flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Santa Ana, California flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Santa Ana, California flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Santa Ana, California flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Santa Ana, California flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Santa Ana
Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Des Moines with our price prediction graph.
DSM-SNA
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Santa Ana
How far ahead should I book a flight from Des Moines to Santa Ana, California?
To ensure you get the cheapest price possible for a flight from Des Moines to Santa Ana, California, you should look to book at least 29 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
What is the cheapest month to book a flight from Des Moines to Santa Ana, California?
Currently, January is the cheapest month in which you can book a flight from Des Moines to Santa Ana, California (average of $164). Flying from Des Moines to Santa Ana, California in March is currently the most expensive (average of $586). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Santa Ana, California?
Airfare is below average for this route at the moment.
Des Moines to Santa Ana, California flights typically cost between $260 and $642 in January.The cheapest round-trip price found within the last 5 days was $120 on Allegiant Air (Jan 18-Jan 22).
Reviews of airlines servicing Santa Ana
Get insights into the airlines that provide service to Santa Ana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Ana. Reviews last updated August 4, 2026.
Read through reviews of airlines operating flights from Des Moines to Santa Ana, such as Southwest,United Airlines, andAllegiant Air. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Overall
8.0
Crew
8.6
Entertainment
7.5
Comfort
8.0
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Overall
8.0
Crew
8.6
Entertainment
7.5
Comfort
8.0
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Overall
8.0
Crew
8.6
Entertainment
7.5
Comfort
8.0
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Overall
8.0
Crew
8.6
Entertainment
7.5
Comfort
8.0
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Overall
8.0
Crew
8.6
Entertainment
7.5
Comfort
8.0
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Santa Ana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Santa Ana?
Book flights to Santa Ana if you plan to visit one of these locationsTustin
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Des Moines and Santa Ana flights
Browse other Des Moines and Santa Ana flight options. Last updated on August 4, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on August 4, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santa Ana
Explore flights to Santa Ana departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 4, 2026.
Top 4 airlines flying from Des Moines to Santa Ana
Discover the top 4 airlines that operate flights from Des Moines to Santa Ana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$114 | Average$225 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$260 | Average$424 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$294 | Average$424 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$340 | Average$466 | FlexibilityNo cancel fee | On-time63% |