$111+ Cheap flights from Des Moines to San Diego (DSM - SAN)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/11. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAN
May 26 — Jun 21
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Des Moines to San Diego are usually found in August or September, booked 36 days in advance, depart on a Monday or Tuesday and return on a Wednesday
Cheap flight deals from Des Moines to San Diego
Cheapest
Best
Last-minute
One-way
Cheapest flights from Des Moines to San DiegoExplore the most affordable flight options available from Des Moines to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 26, 2026.
Explore the most affordable flight options available from Des Moines to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 26, 2026.
This Expedia deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/152:16 pm
DSM
- SAN
1 stop11h 34m
Frontier
Mon 5/186:25 am
SAN
- DSM
1 stop5h 06m
Frontier
Deal found 4/23![Frontier logo]()
$205
This Expedia deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
- SAN
1 stop11h 34m
Frontier
Fri 5/296:25 am
SAN
- DSM
1 stop5h 06m
Frontier
Deal found 4/26![Frontier logo]()
$210
This Frontier deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/102:16 pm
DSM
- SAN
1 stop11h 37m
Frontier
Wed 6/176:25 am
SAN
- DSM
1 stop5h 06m
Frontier
Deal found 4/26![Frontier logo]()
$211
This Booking.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
- SAN
1 stop20h 26m
Frontier
Thu 6/49:37 am
SAN
- DSM
1 stop25h 54m
Frontier
Deal found 4/26![Frontier logo]()
$223
This Frontier deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
- SAN
1 stop11h 34m
Frontier
Fri 6/56:25 am
SAN
- DSM
1 stop5h 06m
Frontier
Deal found 4/21![Frontier logo]()
$230
This Booking.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/52:16 pm
DSM
- SAN
1 stop11h 34m
Frontier
Tue 6/3010:04 am
SAN
- DSM
1 stop25h 27m
Frontier
Deal found 4/23![Frontier logo]()
$243
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
- SAN
1 stop20h 26m
Multiple Airlines
Thu 6/49:37 am
SAN
- DSM
2 stops23h 45m
Multiple Airlines
Deal found 4/25![Multiple Airlines logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/152:16 pm
DSM
- SAN
1 stop11h 34m
Multiple Airlines
Sun 5/179:59 pm
SAN
- DSM
1 stop22h 34m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$252
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/99:44 pm
DSM
- SAN
1 stop23h 47m
Multiple Airlines
Thu 8/209:53 pm
SAN
- DSM
1 stop18h 55m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$257
This Expedia deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:16 pm
DSM
- SAN
1 stop11h 34m
Frontier
Mon 5/116:25 am
SAN
- DSM
1 stop5h 06m
Frontier
Deal found 4/24![Frontier logo]()
$260
Best flights from Des Moines to San DiegoDiscover carefully curated flight deals from Des Moines to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 26, 2026.
Discover carefully curated flight deals from Des Moines to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 26, 2026.
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/235:00 am
DSM
- SAN
2 stops14h 26m
United Airlines
Mon 9/287:41 pm
SAN
- DSM
2 stops12h 39m
United Airlines
Deal found 4/21![United Airlines logo]()
$377
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/812:10 pm
DSM
- SAN
2 stops7h 55m
Southwest
Tue 8/1812:20 pm
SAN
- DSM
2 stops6h 40m
Southwest
Deal found 4/23![Southwest logo]()
$427
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/163:30 pm
DSM
- SAN
1 stop6h 55m
Delta
Mon 10/1910:30 pm
SAN
- DSM
1 stop8h 54m
Delta
Deal found 4/25![Delta logo]()
$447
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/66:55 pm
DSM
- SAN
1 stop5h 25m
Southwest
Sat 6/1311:30 am
SAN
- DSM
2 stops8h 25m
Southwest
Deal found 4/22![Southwest logo]()
$433
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/26:08 am
DSM
- SAN
1 stop10h 04m
Delta
Sun 7/510:15 pm
SAN
- DSM
1 stop9h 29m
Delta
Deal found 4/26![Delta logo]()
$447
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/1611:30 am
DSM
- SAN
1 stop10h 05m
Delta
Sun 7/196:15 am
SAN
- DSM
1 stop8h 57m
Delta
Deal found 4/26![Delta logo]()
$447
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/256:55 pm
DSM
- SAN
1 stop5h 25m
Southwest
Thu 7/3012:55 pm
SAN
- DSM
2 stops7h 25m
Southwest
Deal found 4/23![Southwest logo]()
$452
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/125:10 am
DSM
- SAN
1 stop9h 00m
Southwest
Mon 6/1510:40 pm
SAN
- DSM
1 stop10h 50m
Southwest
Deal found 4/22![Southwest logo]()
$452
Last-minute flights from Des Moines to San DiegoDiscover last-minute flight deals from Des Moines to San Diego. Data last updated April 26, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to San Diego. Data last updated April 26, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:04 pm
DSM
- SAN
1 stop11h 55m
Frontier
Fri 5/86:25 am
SAN
- DSM
1 stop5h 06m
Frontier
Deal found 4/24![Frontier logo]()
$301
This Expedia deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:16 pm
DSM
- SAN
1 stop11h 34m
Frontier
Mon 5/116:25 am
SAN
- DSM
1 stop5h 06m
Frontier
Deal found 4/24![Frontier logo]()
$260
This Expedia deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/112:16 pm
DSM
- SAN
1 stop11h 34m
Frontier
Fri 5/156:25 am
SAN
- DSM
1 stop5h 06m
Frontier
Deal found 4/23![Frontier logo]()
$271
This Booking.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/112:16 pm
DSM
- SAN
1 stop11h 34m
Frontier
Thu 5/149:37 am
SAN
- DSM
1 stop25h 54m
Frontier
Deal found 4/23![Frontier logo]()
$284
This Expedia deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/152:16 pm
DSM
- SAN
1 stop11h 34m
Frontier
Mon 5/186:25 am
SAN
- DSM
1 stop5h 06m
Frontier
Deal found 4/23![Frontier logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/152:16 pm
DSM
- SAN
1 stop11h 34m
Multiple Airlines
Sun 5/179:59 pm
SAN
- DSM
1 stop22h 34m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$252
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/202:39 pm
DSM
- SAN
1 stop5h 46m
American Airlines
Wed 5/273:10 pm
SAN
- DSM
1 stop6h 47m
American Airlines
Deal found 4/22![American Airlines logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/259:42 pm
DSM
- SAN
1 stop25h 30m
Multiple Airlines
Sun 5/316:25 am
SAN
- DSM
1 stop29h 06m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$289
This Expedia deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
- SAN
1 stop11h 34m
Frontier
Fri 5/296:25 am
SAN
- DSM
1 stop5h 06m
Frontier
Deal found 4/26![Frontier logo]()
$210
This Frontier deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- SAN
1 stop11h 34m
Frontier
Mon 6/16:25 am
SAN
- DSM
1 stop5h 06m
Frontier
Deal found 4/22![Frontier logo]()
$290
One-way flights from Des Moines to San DiegoSearch for one-way flight options from Des Moines to San Diego. Find affordable one-way fares based on user searches. Data last updated April 26, 2026.
Search for one-way flight options from Des Moines to San Diego. Find affordable one-way fares based on user searches. Data last updated April 26, 2026.
This Expedia deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/112:16 pm
DSM
- SAN
1 stop11h 34m
Frontier
Deal found 4/22![Frontier logo]()
$111
This Expedia deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/102:19 pm
DSM
- SAN
1 stop11h 32m
Frontier
Deal found 4/22![Frontier logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/99:44 pm
DSM
- SAN
1 stop23h 47m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$143
This Expedia deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/172:19 pm
DSM
- SAN
1 stop20h 46m
Frontier
Deal found 4/25![Frontier logo]()
$151
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/307:01 pm
DSM
- SAN
1 stop6h 58m
American Airlines
Deal found 4/23![American Airlines logo]()
$152
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1211:31 am
DSM
- SAN
1 stop5h 25m
United Airlines
Deal found 4/22![United Airlines logo]()
$180
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:14 pm
DSM
- SAN
1 stop17h 03m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$195
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/171:37 pm
DSM
- SAN
2 stops21h 28m
Multiple Airlines
Deal found 4/25![Multiple Airlines logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/113:46 pm
DSM
- SAN
2 stops25h 45m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$206
Find flight deals from Des Moines to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 26, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $205 (Expedia) |
One-way from | $111 (Expedia) |
Popular in | March |
Cheapest in | August |
Average price | $396 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 26, 2026.
Use the filters below to find and compare flights from Des Moines to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Wed 9/23
5:00 am-5:26 pm
2 stops14h 26m
San Diego
Mon 9/28
7:41 pm-10:20 am
2 stops12h 39m
$377
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Sat 8/8
12:10 pm-6:05 pm
2 stops7h 55m
San Diego
Tue 8/18
12:20 pm-9:00 pm
2 stops6h 40m
$427
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Sat 6/6
6:55 pm-10:20 pm
1 stop5h 25m
San Diego
Sat 6/13
11:30 am-9:55 pm
2 stops8h 25m
$433
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Fri 10/16
3:30 pm-8:25 pm
1 stop6h 55m
San Diego
Mon 10/19
10:30 pm-9:24 am
1 stop8h 54m
$447
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Thu 7/2
6:08 am-2:12 pm
1 stop10h 04m
San Diego
Sun 7/5
10:15 pm-9:44 am
1 stop9h 29m
$447
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Thu 7/16
11:30 am-7:35 pm
1 stop10h 05m
San Diego
Sun 7/19
6:15 am-5:12 pm
1 stop8h 57m
$447
Quickest round-trip
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Sat 7/25
6:55 pm-10:20 pm
1 stop5h 25m
San Diego
Thu 7/30
12:55 pm-10:20 pm
2 stops7h 25m
$452
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Fri 6/12
5:10 am-12:10 pm
1 stop9h 00m
San Diego
Mon 6/15
10:40 pm-11:30 am
1 stop10h 50m
$452
Cheapest one-way
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Fri 7/10
2:19 pm-11:51 pm
1 stop11h 32m
$131
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Mon 5/11
2:16 pm-11:50 pm
1 stop11h 34m
$132
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from Des Moines to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Diego in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Des Moines-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Des Moines with our price prediction graph.
DSM-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to San Diego
How far ahead should I book a flight from Des Moines to San Diego?
The price you pay for your flight from Des Moines to San Diego may vary depending on when you book. For the best chance of a lower fare, look to book 35 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Des Moines to San Diego?
Currently, August is the cheapest month in which you can book a flight from Des Moines to San Diego (average of $233). Flying from Des Moines to San Diego in March is currently the most expensive (average of $576). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to San Diego?
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated April 26, 2026.
Read through reviews of airlines operating flights from Des Moines to San Diego, such as Southwest,United Airlines, andAllegiant Air. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
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Top 6 airlines flying from Des Moines to San Diego
Discover the top 6 airlines that operate flights from Des Moines to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$100 | Average$239 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$101 | Average$156 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$118 | Average$333 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$286 | Average$408 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$286 | Average$378 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$303 | Average$479 | FlexibilityNo cancel fee | On-time63% |