$135+ Cheap flights from Des Moines to San Diego (DSM - SAN)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/12. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAN
Nov 20 — Nov 271
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to San Diego
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Cheapest flights from Des Moines to San DiegoExplore the most affordable flight options available from Des Moines to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 21, 2026.
Explore the most affordable flight options available from Des Moines to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 21, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/178:26 pm -
1 stop29h 32m
Thu 12/247:56 pm -
1 stop18h 09m
Deal found 10/20![Multiple Airlines logo]()
$238
This Frontier deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/178:26 pm -
1 stop5h 32m
Thu 12/246:36 am -
1 stop10h 55m
Deal found 10/20![Frontier logo]()
$267
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/103:01 pm -
1 stop8h 25m
Wed 11/114:18 pm -
1 stop5h 24m
Deal found 10/20![United Airlines logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/239:31 pm -
1 stop20h 03m
Thu 11/268:50 am -
2 stops8h 43m
Deal found 10/19![Multiple Airlines logo]()
$270
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:00 am -
2 stops8h 05m
Tue 11/171:50 pm -
1 stop5h 00m
Deal found 10/20![Southwest logo]()
$274
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/195:00 am -
1 stop5h 40m
Mon 11/2310:45 pm -
1 stop8h 16m
Deal found 10/21![American Airlines logo]()
$276
This Frontier deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/228:28 pm -
1 stop5h 29m
Thu 11/266:30 am -
1 stop11h 03m
Deal found 10/19![Frontier logo]()
$282
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/119:18 pm -
1 stop12h 44m
Wed 12/169:58 am -
2 stops31h 33m
Deal found 10/16![Multiple Airlines logo]()
$289
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/209:31 pm -
1 stop12h 24m
Wed 11/251:02 pm -
2 stops28h 31m
Deal found 10/19![Multiple Airlines logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/209:31 pm -
1 stop12h 24m
Thu 11/268:50 am -
2 stops8h 43m
Deal found 10/19![Multiple Airlines logo]()
$298
Best flights from Des Moines to San DiegoDiscover carefully curated flight deals from Des Moines to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 21, 2026.
Discover carefully curated flight deals from Des Moines to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 21, 2026.
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:00 am -
2 stops8h 05m
Tue 11/171:50 pm -
1 stop5h 00m
Deal found 10/20![Southwest logo]()
$274
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/195:12 pm -
1 stop7h 20m
Wed 12/2310:30 pm -
1 stop7h 25m
Deal found 10/20![United Airlines logo]()
$306
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2411:00 am -
2 stops14h 53m
Thu 11/266:25 am -
1 stop5h 43m
Deal found 10/19![Delta logo]()
$500
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:30 pm -
1 stop5h 25m
Tue 12/810:30 am -
2 stops8h 20m
Deal found 10/20![Southwest logo]()
$274
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/198:00 am -
2 stops11h 17m
Sat 11/212:30 pm -
2 stops7h 12m
Deal found 10/20![United Airlines logo]()
$427
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/215:12 pm -
2 stops9h 07m
Thu 12/248:45 am -
2 stops12h 30m
Deal found 10/20![United Airlines logo]()
$427
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/265:10 am -
2 stops10h 50m
Mon 11/3010:40 pm -
1 stop10h 45m
Deal found 10/20![Southwest logo]()
$445
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:00 am -
2 stops7h 40m
Sat 11/2112:10 pm -
2 stops7h 40m
Deal found 10/19![Southwest logo]()
$475
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/215:12 pm -
2 stops8h 39m
Fri 12/256:45 am -
2 stops8h 55m
Deal found 10/16![United Airlines logo]()
$495
This Southwest deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/176:55 am -
2 stops8h 00m
Sat 1/2310:15 am -
2 stops7h 05m
Deal found 10/17![Southwest logo]()
$487
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/61:27 pm -
2 stops9h 04m
Tue 11/1010:40 am -
1 stop9h 15m
Deal found 10/16![United Airlines logo]()
$510
Last-minute flights from Des Moines to San DiegoDiscover last-minute flight deals from Des Moines to San Diego. Data last updated October 21, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to San Diego. Data last updated October 21, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/103:01 pm -
1 stop8h 25m
Wed 11/114:18 pm -
1 stop5h 24m
Deal found 10/20![United Airlines logo]()
$269
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:00 am -
2 stops8h 00m
Tue 11/1710:55 am -
2 stops7h 55m
Deal found 10/20![Southwest logo]()
$280
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/195:00 am -
1 stop5h 40m
Mon 11/2310:45 pm -
1 stop8h 16m
Deal found 10/21![American Airlines logo]()
$276
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/209:31 pm -
1 stop12h 24m
Wed 11/251:02 pm -
2 stops28h 31m
Deal found 10/19![Multiple Airlines logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/209:31 pm -
1 stop12h 24m
Thu 11/268:50 am -
2 stops8h 43m
Deal found 10/19![Multiple Airlines logo]()
$298
This Frontier deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/228:28 pm -
1 stop5h 29m
Thu 11/266:30 am -
1 stop11h 03m
Deal found 10/19![Frontier logo]()
$282
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/223:00 pm -
1 stop18h 55m
Wed 11/251:02 pm -
2 stops28h 31m
Deal found 10/19![Multiple Airlines logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/223:00 pm -
1 stop18h 55m
Thu 11/268:50 am -
2 stops8h 43m
Deal found 10/19![Multiple Airlines logo]()
$300
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/239:31 pm -
1 stop20h 03m
Thu 11/268:50 am -
2 stops8h 43m
Deal found 10/19![Multiple Airlines logo]()
$270
One-way flights from Des Moines to San DiegoSearch for one-way flight options from Des Moines to San Diego. Find affordable one-way fares based on user searches. Data last updated October 21, 2026.
Search for one-way flight options from Des Moines to San Diego. Find affordable one-way fares based on user searches. Data last updated October 21, 2026.
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:00 am -
1 stop5h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![American Airlines logo]()
$135
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:40 am -
2 stops7h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![Southwest logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/151:42 pm -
2 stops46h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![Multiple Airlines logo]()
$164
This Cheapflightsfares deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/28:30 pm -
1 stop5h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Frontier logo]()
$188
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/156:05 am -
1 stop7h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![United Airlines logo]()
$190
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/198:00 am -
2 stops11h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![United Airlines logo]()
$195
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/298:23 pm -
1 stop18h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![Multiple Airlines logo]()
$215
This Kiwi.com deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/14:55 pm -
1 stop21h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![Multiple Airlines logo]()
$218
This Kiwi.com deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/308:13 pm -
1 stop18h 16m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![Multiple Airlines logo]()
$227
Find flight deals from Des Moines to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 21, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $238 (Kiwi.com) |
One-way from | $135 (American Airlines) |
Popular in | March |
Cheapest in | April |
Average price | $369 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 21, 2026.
Use the filters below to find and compare flights from Des Moines to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSan Diego
DSM Des Moines - SAN San Diego
DSMSAN
Des Moines
Thu 11/12
6:40 am-12:15 pm
2 stops7h 35m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$140
Quickest round-trip
Des MoinesSan Diego
DSM Des Moines - SAN San Diego
DSMSAN
Des Moines
Sun 11/15
6:05 am-11:27 am
1 stop7h 22m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$190
Des MoinesSan Diego
DSM Des Moines - SAN San Diego
DSMSAN
Des Moines
Thu 11/19
8:00 am-5:17 pm
2 stops11h 17m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$195
Des MoinesSan Diego
DSM Des Moines - SAN San Diego
DSMSAN
Des Moines
Tue 12/29
8:23 pm-12:24 pm
1 stop18h 01m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$215
Des MoinesSan Diego
DSM Des Moines - SAN San Diego
DSMSAN
Des Moines
Fri 1/1
4:55 pm-12:29 pm
1 stop21h 34m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$218
Des MoinesSan Diego
DSM Des Moines - SAN San Diego
DSMSAN
Des Moines
Wed 12/30
8:13 pm-12:29 pm
1 stop18h 16m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$227
Des MoinesSan Diego
DSM Des Moines - SAN San Diego
DSMSAN
Des Moines
Sun 11/15
1:00 pm-6:38 pm
3 stops31h 38m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$240
Des MoinesSan Diego
DSM Des Moines - SAN San Diego
DSMSAN
Des Moines
Wed 11/4
2:45 pm-11:57 pm
2 stops35h 12m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$252
Des MoinesSan Diego
DSM Des Moines - SAN San Diego
DSMSAN
Des Moines
Tue 11/10
7:00 am-1:05 pm
2 stops8h 05m
San Diego
Tue 11/17
1:50 pm-8:50 pm
1 stop5h 00m
$274
Des MoinesSan Diego
DSM Des Moines - SAN San Diego
DSMSAN
Des Moines
Thu 12/3
6:30 pm-9:55 pm
1 stop5h 25m
San Diego
Tue 12/8
10:30 am-8:50 pm
2 stops8h 20m
$274
Showing 1-10 of 22 resultsSorted by cheapest first
Compare providers for flights from Des Moines to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Diego in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Des Moines-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Des Moines with our price prediction graph.
DSM-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to San Diego
How far ahead should I book a flight from Des Moines to San Diego?
The price you pay for your flight from Des Moines to San Diego may vary depending on when you book. For the best chance of a lower fare, look to book 8 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Des Moines to San Diego?
Currently, April is the cheapest month in which you can book a flight from Des Moines to San Diego (average of $362). Flying from Des Moines to San Diego in March is currently the most expensive (average of $589). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to San Diego?
Airfare is below average for this route at the moment.
Des Moines to San Diego flights typically cost between $326 and $518 in December.The cheapest round-trip price found within the last 5 days was $238 on Multiple Airlines (Dec 17-Dec 24).
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated October 21, 2026.
Read through reviews of airlines operating flights from Des Moines to San Diego, such as Southwest,Delta, andUnited Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.4
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Overall
7.9
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.4
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Overall
7.9
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.4
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Overall
7.9
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.4
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Overall
7.9
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.4
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Overall
7.9
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.4
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Des Moines to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Top 5 airlines flying from Des Moines to San Diego
Discover the top 5 airlines that operate flights from Des Moines to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 21, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$116 | Average$270 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$148 | Average$371 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$272 | Average$406 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$296 | Average$471 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$336 | Average$429 | FlexibilityNo cancel fee | On-time69% |