$106+ Cheap flights from Des Moines to San Diego (DSM - SAN)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/27. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAN
Jun 9 — Jun 161
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Des Moines to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Des Moines to San Diego are usually found in August or September, booked 36 days in advance, depart on a Monday or Tuesday and return on a Wednesday
Cheap flight deals from Des Moines to San Diego
Cheapest
Best
Last-minute
One-way
Cheapest flights from Des Moines to San DiegoExplore the most affordable flight options available from Des Moines to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 10, 2026.
Explore the most affordable flight options available from Des Moines to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/299:36 pm
DSM
- SAN
1 stop25h 36m
Multiple Airlines
Tue 6/26:25 am
SAN
- DSM
1 stop29h 06m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$220
This Frontier deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/82:16 pm
DSM
- SAN
1 stop11h 34m
Frontier
Wed 6/106:25 am
SAN
- DSM
1 stop5h 06m
Frontier
Deal found 5/7![Frontier logo]()
$224
This Expedia deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- SAN
1 stop20h 26m
Frontier
Wed 6/36:25 am
SAN
- DSM
1 stop5h 06m
Frontier
Deal found 5/6![Frontier logo]()
$230
This Booking.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/242:16 pm
DSM
- SAN
1 stop20h 53m
Frontier
Mon 6/296:25 am
SAN
- DSM
1 stop5h 06m
Frontier
Deal found 5/8![Frontier logo]()
$237
This Expedia deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- SAN
1 stop11h 34m
Frontier
Mon 6/16:25 am
SAN
- DSM
1 stop5h 06m
Frontier
Deal found 5/8![Frontier logo]()
$244
This Booking.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/52:16 pm
DSM
- SAN
1 stop11h 34m
Frontier
Tue 6/91:28 pm
SAN
- DSM
1 stop22h 03m
Frontier
Deal found 5/8![Frontier logo]()
$252
This Kiwi.com deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/99:44 pm
DSM
- SAN
1 stop23h 47m
Multiple Airlines
Sat 8/158:29 pm
SAN
- DSM
1 stop22h 25m
Multiple Airlines
Deal found 5/9![Multiple Airlines logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/229:56 pm
DSM
- SAN
1 stop12h 52m
Multiple Airlines
Mon 6/294:17 pm
SAN
- DSM
2 stops42h 42m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$267
This Expedia deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/222:26 pm
DSM
- SAN
1 stop20h 43m
Frontier
Mon 6/296:25 am
SAN
- DSM
1 stop5h 06m
Frontier
Deal found 5/9![Frontier logo]()
$270
Best flights from Des Moines to San DiegoDiscover carefully curated flight deals from Des Moines to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 10, 2026.
Discover carefully curated flight deals from Des Moines to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 10, 2026.
This Southwest deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/97:00 pm
DSM
- SAN
1 stop5h 55m
Southwest
Tue 6/1612:10 pm
SAN
- DSM
2 stops7h 30m
Southwest
Deal found 5/10![Southwest logo]()
$407
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/254:47 pm
DSM
- SAN
1 stop8h 10m
Delta
Thu 7/3010:30 pm
SAN
- DSM
1 stop10h 15m
Delta
Deal found 5/9![Delta logo]()
$452
This Expedia deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/152:16 pm
DSM
- SAN
1 stop11h 34m
Frontier
Fri 5/226:25 am
SAN
- DSM
1 stop5h 06m
Frontier
Deal found 5/5![Frontier logo]()
$515
This Southwest deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/63:50 pm
DSM
- SAN
1 stop9h 05m
Southwest
Fri 8/710:40 pm
SAN
- DSM
1 stop10h 50m
Southwest
Deal found 5/7![Southwest logo]()
$452
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/306:50 am
DSM
- SAN
1 stop8h 39m
Delta
Sun 7/57:56 pm
SAN
- DSM
2 stops16h 09m
Delta
Deal found 5/5![Delta logo]()
$476
This Southwest deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/94:40 pm
DSM
- SAN
1 stop8h 45m
Southwest
Sun 7/126:40 am
SAN
- DSM
2 stops6h 55m
Southwest
Deal found 5/7![Southwest logo]()
$462
This Southwest deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/246:25 am
DSM
- SAN
2 stops8h 40m
Southwest
Wed 7/112:10 pm
SAN
- DSM
2 stops7h 30m
Southwest
Deal found 5/10![Southwest logo]()
$467
This Southwest deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:10 am
DSM
- SAN
2 stops7h 10m
Southwest
Mon 6/151:20 pm
SAN
- DSM
2 stops8h 10m
Southwest
Deal found 5/7![Southwest logo]()
$487
This Southwest deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/16:25 am
DSM
- SAN
2 stops8h 40m
Southwest
Sun 7/57:20 am
SAN
- DSM
2 stops8h 10m
Southwest
Deal found 5/5![Southwest logo]()
$493
This Southwest deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/166:10 am
DSM
- SAN
2 stops7h 20m
Southwest
Sun 7/196:35 am
SAN
- DSM
2 stops15h 10m
Southwest
Deal found 5/7![Southwest logo]()
$509
This Southwest deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:10 am
DSM
- SAN
2 stops7h 10m
Southwest
Wed 6/107:50 am
SAN
- DSM
2 stops8h 30m
Southwest
Deal found 5/7![Southwest logo]()
$515
Last-minute flights from Des Moines to San DiegoDiscover last-minute flight deals from Des Moines to San Diego. Data last updated May 10, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to San Diego. Data last updated May 10, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/299:36 pm
DSM
- SAN
1 stop25h 36m
Multiple Airlines
Tue 6/26:25 am
SAN
- DSM
1 stop29h 06m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$220
This Expedia deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- SAN
1 stop20h 26m
Frontier
Wed 6/36:25 am
SAN
- DSM
1 stop5h 06m
Frontier
Deal found 5/6![Frontier logo]()
$230
This Expedia deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- SAN
1 stop11h 34m
Frontier
Mon 6/16:25 am
SAN
- DSM
1 stop5h 06m
Frontier
Deal found 5/8![Frontier logo]()
$244
This Kiwi.com deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/299:36 pm
DSM
- SAN
1 stop25h 36m
Multiple Airlines
Wed 6/34:17 pm
SAN
- DSM
2 stops25h 54m
Multiple Airlines
Deal found 5/6![Multiple Airlines logo]()
$272
This Booking.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/52:16 pm
DSM
- SAN
1 stop11h 34m
Frontier
Tue 6/91:28 pm
SAN
- DSM
1 stop22h 03m
Frontier
Deal found 5/8![Frontier logo]()
$252
This Frontier deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/82:16 pm
DSM
- SAN
1 stop11h 34m
Frontier
Wed 6/106:25 am
SAN
- DSM
1 stop5h 06m
Frontier
Deal found 5/7![Frontier logo]()
$224
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/229:56 pm
DSM
- SAN
1 stop12h 52m
Multiple Airlines
Mon 6/294:17 pm
SAN
- DSM
2 stops42h 42m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$267
This Expedia deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/222:26 pm
DSM
- SAN
1 stop20h 43m
Frontier
Mon 6/296:25 am
SAN
- DSM
1 stop5h 06m
Frontier
Deal found 5/9![Frontier logo]()
$270
This Booking.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/242:16 pm
DSM
- SAN
1 stop20h 53m
Frontier
Mon 6/296:25 am
SAN
- DSM
1 stop5h 06m
Frontier
Deal found 5/8![Frontier logo]()
$237
One-way flights from Des Moines to San DiegoSearch for one-way flight options from Des Moines to San Diego. Find affordable one-way fares based on user searches. Data last updated May 10, 2026.
Search for one-way flight options from Des Moines to San Diego. Find affordable one-way fares based on user searches. Data last updated May 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/271:49 pm
DSM
- SAN
1 stop9h 23m
Multiple Airlines
Deal found 5/6![Multiple Airlines logo]()
$106
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/310:01 pm
DSM
- SAN
1 stop24h 57m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$107
This Kiwi.com deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/19:17 pm
DSM
- SAN
1 stop13h 30m
Multiple Airlines
Deal found 5/6![Multiple Airlines logo]()
$123
This Frontier deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/12:16 pm
DSM
- SAN
1 stop11h 37m
Frontier
Deal found 5/8![Frontier logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/3110:26 pm
DSM
- SAN
1 stop22h 15m
Multiple Airlines
Deal found 5/6![Multiple Airlines logo]()
$127
This Frontier deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- SAN
1 stop11h 34m
Frontier
Deal found 5/6![Frontier logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/59:33 pm
DSM
- SAN
1 stop23h 58m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$137
This Kiwi.com deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/299:36 pm
DSM
- SAN
1 stop25h 36m
Multiple Airlines
Deal found 5/6![Multiple Airlines logo]()
$139
This Kiwi.com deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/289:34 pm
DSM
- SAN
1 stop25h 38m
Multiple Airlines
Deal found 5/6![Multiple Airlines logo]()
$141
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/310:01 pm
DSM
- SAN
1 stop23h 33m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$152
Find flight deals from Des Moines to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $220 (Kiwi.com) |
One-way from | $106 (Kiwi.com) |
Popular in | March |
Cheapest in | August |
Average price | $362 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 10, 2026.
Use the filters below to find and compare flights from Des Moines to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Tue 6/9
7:00 pm-10:55 pm
1 stop5h 55m
San Diego
Tue 6/16
12:10 pm-9:40 pm
2 stops7h 30m
$407
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Sat 7/25
4:47 pm-10:57 pm
1 stop8h 10m
San Diego
Thu 7/30
10:30 pm-10:45 am
1 stop10h 15m
$452
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Thu 8/6
3:50 pm-10:55 pm
1 stop9h 05m
San Diego
Fri 8/7
10:40 pm-11:30 am
1 stop10h 50m
$452
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Thu 7/9
4:40 pm-11:25 pm
1 stop8h 45m
San Diego
Sun 7/12
6:40 am-3:35 pm
2 stops6h 55m
$462
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Wed 6/24
6:25 am-1:05 pm
2 stops8h 40m
San Diego
Wed 7/1
12:10 pm-9:40 pm
2 stops7h 30m
$467
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Tue 6/30
6:50 am-1:29 pm
1 stop8h 39m
San Diego
Sun 7/5
7:56 pm-2:05 pm
2 stops16h 09m
$476
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Thu 6/11
6:10 am-11:20 am
2 stops7h 10m
San Diego
Mon 6/15
1:20 pm-11:30 pm
2 stops8h 10m
$487
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Wed 7/1
6:25 am-1:05 pm
2 stops8h 40m
San Diego
Sun 7/5
7:20 am-5:30 pm
2 stops8h 10m
$493
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Thu 7/16
6:10 am-11:30 am
2 stops7h 20m
San Diego
Sun 7/19
6:35 am-11:45 pm
2 stops15h 10m
$509
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Fri 5/15
2:16 pm-11:50 pm
1 stop11h 34m
San Diego
Fri 5/22
6:25 am-1:31 pm
1 stop5h 06m
$515
Showing 1-10 of 20 resultsSorted by cheapest first
Compare providers for flights from Des Moines to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Diego in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Des Moines-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Des Moines with our price prediction graph.
DSM-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to San Diego
How far ahead should I book a flight from Des Moines to San Diego?
The price you pay for your flight from Des Moines to San Diego may vary depending on when you book. For the best chance of a lower fare, look to book 8 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Des Moines to San Diego?
Currently, August is the cheapest month in which you can book a flight from Des Moines to San Diego (average of $188). Flying from Des Moines to San Diego in March is currently the most expensive (average of $576). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to San Diego?
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated May 10, 2026.
Read through reviews of airlines operating flights from Des Moines to San Diego, such as Southwest,United Airlines, andAllegiant Air. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
7.9
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
7.9
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
7.9
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
7.9
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
7.9
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
7.9
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Des Moines to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Des Moines
Popular flights
San Diego flight routes
Alternative routes for Des Moines to San Diego
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to San Diego by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Des Moines to San Diego by cabin class
Find flights from Des Moines to San Diego, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and San Diego flights
Browse other Des Moines and San Diego flight options. Last updated on May 10, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on May 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Diego
Explore flights to San Diego departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 10, 2026.
Top 6 airlines flying from Des Moines to San Diego
Discover the top 6 airlines that operate flights from Des Moines to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$100 | Average$248 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$101 | Average$154 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$118 | Average$333 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$286 | Average$408 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$286 | Average$389 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$303 | Average$474 | FlexibilityNo cancel fee | On-time63% |