$100+ Cheap flights from Des Moines to San Diego (DSM - SAN)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/16. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAN
Aug 24 — Aug 311
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Des Moines to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to San Diego
Cheapest
Best
Last-minute
One-way
Cheapest flights from Des Moines to San DiegoExplore the most affordable flight options available from Des Moines to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 25, 2026.
Explore the most affordable flight options available from Des Moines to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 25, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/239:50 pm
DSM
- SAN
1 stop24h 24m
Multiple Airlines
Thu 8/278:59 pm
SAN
- DSM
1 stop19h 49m
Multiple Airlines
Deal found 7/22![Multiple Airlines logo]()
$173
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:19 pm
DSM
- SAN
1 stop20h 46m
Multiple Airlines
Thu 8/278:59 pm
SAN
- DSM
1 stop19h 49m
Multiple Airlines
Deal found 7/22![Multiple Airlines logo]()
$196
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1710:06 pm
DSM
- SAN
2 stops24h 09m
Multiple Airlines
Mon 8/246:25 am
SAN
- DSM
1 stop13h 48m
Multiple Airlines
Deal found 7/24![Multiple Airlines logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/169:44 pm
DSM
- SAN
1 stop24h 22m
Multiple Airlines
Wed 8/196:25 am
SAN
- DSM
2 stops36h 35m
Multiple Airlines
Deal found 7/24![Multiple Airlines logo]()
$226
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:19 pm
DSM
- SAN
1 stop11h 32m
Multiple Airlines
Thu 8/278:59 pm
SAN
- DSM
1 stop19h 49m
Multiple Airlines
Deal found 7/22![Multiple Airlines logo]()
$231
This Kiwi.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/302:42 pm
DSM
- SAN
1 stop23h 43m
Multiple Airlines
Sun 10/48:32 pm
SAN
- DSM
1 stop15h 24m
Multiple Airlines
Deal found 7/20![Multiple Airlines logo]()
$237
Best flights from Des Moines to San DiegoDiscover carefully curated flight deals from Des Moines to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 25, 2026.
Discover carefully curated flight deals from Des Moines to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 25, 2026.
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:21 pm
DSM
- SAN
1 stop7h 06m
United Airlines
Tue 8/2511:00 am
SAN
- DSM
1 stop7h 26m
United Airlines
Deal found 7/21![United Airlines logo]()
$347
This Southwest deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1812:30 pm
DSM
- SAN
2 stops7h 55m
Southwest
Tue 8/2511:10 am
SAN
- DSM
2 stops7h 50m
Southwest
Deal found 7/21![Southwest logo]()
$357
This Delta deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:55 am
DSM
- SAN
1 stop7h 13m
Delta
Mon 11/911:40 am
SAN
- DSM
1 stop5h 32m
Delta
Deal found 7/20![Delta logo]()
$375
This United Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:21 pm
DSM
- SAN
1 stop5h 13m
United Airlines
Tue 8/186:20 am
SAN
- DSM
2 stops7h 59m
United Airlines
Deal found 7/20![United Airlines logo]()
$352
This Southwest deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:40 pm
DSM
- SAN
1 stop5h 25m
Southwest
Tue 9/157:25 am
SAN
- DSM
2 stops8h 20m
Southwest
Deal found 7/24![Southwest logo]()
$360
This United Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/51:35 pm
DSM
- SAN
1 stop5h 40m
United Airlines
Mon 11/94:18 pm
SAN
- DSM
1 stop5h 22m
United Airlines
Deal found 7/20![United Airlines logo]()
$375
This Southwest deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/237:15 am
DSM
- SAN
2 stops7h 45m
Southwest
Wed 9/3012:20 pm
SAN
- DSM
2 stops6h 45m
Southwest
Deal found 7/23![Southwest logo]()
$382
This Southwest deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/172:25 pm
DSM
- SAN
2 stops6h 55m
Southwest
Tue 9/2212:20 pm
SAN
- DSM
2 stops6h 40m
Southwest
Deal found 7/21![Southwest logo]()
$402
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/25:11 pm
DSM
- SAN
1 stop5h 25m
United Airlines
Wed 11/412:39 pm
SAN
- DSM
1 stop5h 50m
United Airlines
Deal found 7/21![United Airlines logo]()
$437
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/231:23 pm
DSM
- SAN
1 stop7h 07m
United Airlines
Mon 9/282:24 pm
SAN
- DSM
2 stops7h 24m
United Airlines
Deal found 7/21![United Airlines logo]()
$442
Last-minute flights from Des Moines to San DiegoDiscover last-minute flight deals from Des Moines to San Diego. Data last updated July 25, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to San Diego. Data last updated July 25, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/169:44 pm
DSM
- SAN
1 stop24h 22m
Multiple Airlines
Wed 8/196:25 am
SAN
- DSM
2 stops36h 35m
Multiple Airlines
Deal found 7/24![Multiple Airlines logo]()
$226
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1710:06 pm
DSM
- SAN
2 stops24h 09m
Multiple Airlines
Mon 8/246:25 am
SAN
- DSM
1 stop13h 48m
Multiple Airlines
Deal found 7/24![Multiple Airlines logo]()
$204
This Expedia deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/172:19 pm
DSM
- SAN
1 stop11h 32m
Frontier
Mon 8/246:25 am
SAN
- DSM
1 stop5h 09m
Frontier
Deal found 7/24![Frontier logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:19 pm
DSM
- SAN
1 stop11h 32m
Multiple Airlines
Thu 8/278:59 pm
SAN
- DSM
1 stop19h 49m
Multiple Airlines
Deal found 7/22![Multiple Airlines logo]()
$231
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/239:50 pm
DSM
- SAN
1 stop24h 24m
Multiple Airlines
Thu 8/278:59 pm
SAN
- DSM
1 stop19h 49m
Multiple Airlines
Deal found 7/22![Multiple Airlines logo]()
$173
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:19 pm
DSM
- SAN
1 stop20h 46m
Multiple Airlines
Thu 8/278:59 pm
SAN
- DSM
1 stop19h 49m
Multiple Airlines
Deal found 7/22![Multiple Airlines logo]()
$196
One-way flights from Des Moines to San DiegoSearch for one-way flight options from Des Moines to San Diego. Find affordable one-way fares based on user searches. Data last updated July 25, 2026.
Search for one-way flight options from Des Moines to San Diego. Find affordable one-way fares based on user searches. Data last updated July 25, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/169:44 pm
DSM
- SAN
1 stop24h 22m
Multiple Airlines
Deal found 7/22![Multiple Airlines logo]()
$100
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1710:06 pm
DSM
- SAN
2 stops24h 09m
Multiple Airlines
Deal found 7/24![Multiple Airlines logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/312:08 pm
DSM
- SAN
1 stop11h 36m
Multiple Airlines
Deal found 7/20![Multiple Airlines logo]()
$114
This Kiwi.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/149:31 pm
DSM
- SAN
2 stops24h 06m
Multiple Airlines
Deal found 7/20![Multiple Airlines logo]()
$121
This Orbitz deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/172:19 pm
DSM
- SAN
1 stop11h 32m
Frontier
Deal found 7/24![Frontier logo]()
$129
This Kiwi.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/282:51 pm
DSM
- SAN
1 stop26h 50m
Frontier
Deal found 7/20![Frontier logo]()
$132
This Kiwi.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/142:51 pm
DSM
- SAN
1 stop26h 50m
Frontier
Deal found 7/20![Frontier logo]()
$133
Find flight deals from Des Moines to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 25, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $173 (Kiwi.com) |
One-way from | $100 (Kiwi.com) |
Popular in | March |
Cheapest in | August |
Average price | $492 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 25, 2026.
Use the filters below to find and compare flights from Des Moines to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Thu 8/13
5:21 pm-10:27 pm
1 stop7h 06m
San Diego
Tue 8/25
11:00 am-8:26 pm
1 stop7h 26m
$347
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Mon 8/17
5:21 pm-8:34 pm
1 stop5h 13m
San Diego
Tue 8/18
6:20 am-4:19 pm
2 stops7h 59m
$352
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Tue 8/18
12:30 pm-6:25 pm
2 stops7h 55m
San Diego
Tue 8/25
11:10 am-9:00 pm
2 stops7h 50m
$357
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Tue 9/8
6:40 pm-10:05 pm
1 stop5h 25m
San Diego
Tue 9/15
7:25 am-5:45 pm
2 stops8h 20m
$360
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Wed 11/4
6:55 am-12:08 pm
1 stop7h 13m
San Diego
Mon 11/9
11:40 am-7:12 pm
1 stop5h 32m
$375
Quickest round-trip
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Thu 11/5
1:35 pm-5:15 pm
1 stop5h 40m
San Diego
Mon 11/9
4:18 pm-11:40 pm
1 stop5h 22m
$375
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Wed 9/23
7:15 am-1:00 pm
2 stops7h 45m
San Diego
Wed 9/30
12:20 pm-9:05 pm
2 stops6h 45m
$382
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Thu 9/17
2:25 pm-7:20 pm
2 stops6h 55m
San Diego
Tue 9/22
12:20 pm-9:00 pm
2 stops6h 40m
$402
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Mon 11/2
5:11 pm-8:36 pm
1 stop5h 25m
San Diego
Wed 11/4
12:39 pm-8:29 pm
1 stop5h 50m
$437
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Wed 9/23
1:23 pm-6:30 pm
1 stop7h 07m
San Diego
Mon 9/28
2:24 pm-11:48 pm
2 stops7h 24m
$442
Showing 1-10 of 20 resultsSorted by cheapest first
Compare providers for flights from Des Moines to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Diego in July.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Des Moines-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Des Moines with our price prediction graph.
DSM-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to San Diego
How far ahead should I book a flight from Des Moines to San Diego?
The price you pay for your flight from Des Moines to San Diego may vary depending on when you book. For the best chance of a lower fare, look to book 42 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Des Moines to San Diego?
Currently, August is the cheapest month in which you can book a flight from Des Moines to San Diego (average of $329). Flying from Des Moines to San Diego in March is currently the most expensive (average of $577). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to San Diego?
Airfare is below average for this route at the moment.
Des Moines to San Diego flights typically cost between $290 and $497 in August.The cheapest round-trip price found within the last 5 days was $173 on Multiple Airlines (Aug 23-Aug 27).
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated July 25, 2026.
Read through reviews of airlines operating flights from Des Moines to San Diego, such as Southwest,Delta, andUnited Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Overall
8.0
Food
7.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Overall
8.0
Food
7.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Overall
8.0
Food
7.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Overall
8.0
Food
7.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Overall
8.0
Food
7.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Overall
8.0
Food
7.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Des Moines to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
National City
Chula Vista
Poway
La Mesa
Coronado
Santee
San Ysidro
Julian
Lemon Grove
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Des Moines
Popular flights
San Diego flight routes
Alternative routes for Des Moines to San Diego
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to San Diego by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Des Moines to San Diego by cabin class
Find flights from Des Moines to San Diego, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and San Diego flights
Browse other Des Moines and San Diego flight options. Last updated on July 25, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on July 25, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Diego
Explore flights to San Diego departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 25, 2026.
Top 6 airlines flying from Des Moines to San Diego
Discover the top 6 airlines that operate flights from Des Moines to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 25, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$89 | Average$172 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$100 | Average$238 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$118 | Average$336 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$286 | Average$415 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$296 | Average$472 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$310 | Average$424 | FlexibilityNo cancel fee | On-time69% |