$92+ Cheap flights from San Diego to Des Moines (SAN - DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/4. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — DSM
Jul 16 — Jul 231
Round-trip
1 adult, Economy
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Find cheap flights from San Diego to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Diego to Des Moines
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Best
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One-way
Cheapest flights from San Diego to Des MoinesExplore the most affordable flight options available from San Diego to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 16, 2026.
Explore the most affordable flight options available from San Diego to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 16, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/199:53 pm
SAN
- DSM
1 stop21h 07m
Multiple Airlines
Sun 8/239:50 pm
DSM
- SAN
1 stop25h 08m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$189
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/209:37 am
SAN
- DSM
1 stop25h 54m
Multiple Airlines
Sun 8/239:50 pm
DSM
- SAN
1 stop25h 08m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$253
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/123:03 pm
SAN
- DSM
1 stop27h 51m
Multiple Airlines
Sun 8/169:44 pm
DSM
- SAN
1 stop24h 22m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$261
This Frontier deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:25 am
SAN
- DSM
1 stop5h 06m
Frontier
Mon 9/72:16 pm
DSM
- SAN
1 stop11h 37m
Frontier
Deal found 6/11![Frontier logo]()
$268
This Booking.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/910:00 am
SAN
- DSM
1 stop25h 34m
Frontier
Wed 7/152:19 pm
DSM
- SAN
1 stop11h 32m
Frontier
Deal found 6/11![Frontier logo]()
$280
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/306:25 am
SAN
- DSM
1 stop29h 09m
Multiple Airlines
Mon 8/310:01 pm
DSM
- SAN
1 stop18h 07m
Multiple Airlines
Deal found 6/11![Multiple Airlines logo]()
$301
Best flights from San Diego to Des MoinesDiscover carefully curated flight deals from San Diego to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 16, 2026.
Discover carefully curated flight deals from San Diego to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 16, 2026.
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:20 am
SAN
- DSM
2 stops7h 59m
United Airlines
Mon 9/75:45 am
DSM
- SAN
1 stop5h 20m
United Airlines
Deal found 6/11![United Airlines logo]()
$395
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:29 am
SAN
- DSM
1 stop8h 21m
Delta
Sun 8/235:56 pm
DSM
- SAN
1 stop7h 39m
Delta
Deal found 6/14![Delta logo]()
$411
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/36:35 am
SAN
- DSM
1 stop7h 25m
Southwest
Tue 7/76:25 am
DSM
- SAN
2 stops8h 15m
Southwest
Deal found 6/15![Southwest logo]()
$473
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:20 am
SAN
- DSM
2 stops7h 59m
United Airlines
Sat 8/159:13 am
DSM
- SAN
1 stop7h 37m
United Airlines
Deal found 6/15![United Airlines logo]()
$398
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1812:01 pm
SAN
- DSM
1 stop8h 29m
United Airlines
Wed 8/196:00 am
DSM
- SAN
1 stop7h 15m
United Airlines
Deal found 6/15![United Airlines logo]()
$437
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:30 am
SAN
- DSM
1 stop7h 49m
United Airlines
Mon 9/75:45 am
DSM
- SAN
1 stop5h 20m
United Airlines
Deal found 6/11![United Airlines logo]()
$437
Last-minute flights from San Diego to Des MoinesDiscover last-minute flight deals from San Diego to Des Moines. Data last updated June 16, 2026 and is based on user searches.
Discover last-minute flight deals from San Diego to Des Moines. Data last updated June 16, 2026 and is based on user searches.
This Trip.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/226:25 am
SAN
- DSM
1 stop5h 06m
Multiple Airlines
Mon 6/299:56 pm
DSM
- SAN
1 stop12h 52m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$330
This American Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/310:45 pm
SAN
- DSM
1 stop7h 28m
American Airlines
Tue 7/75:45 am
DSM
- SAN
1 stop5h 06m
American Airlines
Deal found 6/15![American Airlines logo]()
$357
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/710:45 pm
SAN
- DSM
1 stop7h 38m
American Airlines
Wed 7/87:13 pm
DSM
- SAN
1 stop6h 46m
American Airlines
Deal found 6/12![American Airlines logo]()
$347
This Booking.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/910:00 am
SAN
- DSM
1 stop25h 34m
Frontier
Wed 7/152:19 pm
DSM
- SAN
1 stop11h 32m
Frontier
Deal found 6/11![Frontier logo]()
$280
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/98:51 pm
SAN
- DSM
1 stop22h 32m
Multiple Airlines
Wed 7/151:49 pm
DSM
- SAN
2 stops12h 15m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$353
This Frontier deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/106:25 am
SAN
- DSM
1 stop5h 09m
Frontier
Mon 7/132:19 pm
DSM
- SAN
1 stop11h 32m
Frontier
Deal found 6/11![Frontier logo]()
$319
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/213:08 pm
SAN
- DSM
1 stop6h 50m
American Airlines
Tue 8/46:33 pm
DSM
- SAN
1 stop6h 53m
American Airlines
Deal found 6/11![American Airlines logo]()
$310
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/218:45 am
SAN
- DSM
1 stop5h 30m
United Airlines
Tue 8/45:17 pm
DSM
- SAN
2 stops8h 37m
United Airlines
Deal found 6/11![United Airlines logo]()
$315
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/306:25 am
SAN
- DSM
1 stop29h 09m
Multiple Airlines
Mon 8/310:01 pm
DSM
- SAN
1 stop18h 07m
Multiple Airlines
Deal found 6/11![Multiple Airlines logo]()
$301
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/306:25 am
SAN
- DSM
1 stop29h 09m
Frontier
Wed 8/52:19 pm
DSM
- SAN
1 stop20h 51m
Frontier
Deal found 6/11![Frontier logo]()
$317
One-way flights from San Diego to Des MoinesSearch for one-way flight options from San Diego to Des Moines. Find affordable one-way fares based on user searches. Data last updated June 16, 2026.
Search for one-way flight options from San Diego to Des Moines. Find affordable one-way fares based on user searches. Data last updated June 16, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/43:03 pm
SAN
- DSM
1 stop19h 56m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$92
This Trip.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/213:03 pm
SAN
- DSM
1 stop19h 56m
Multiple Airlines
Deal found 6/11![Multiple Airlines logo]()
$113
This Expedia deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/296:25 am
SAN
- DSM
1 stop5h 09m
Frontier
Deal found 6/13![Frontier logo]()
$124
This Frontier deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:25 am
SAN
- DSM
1 stop5h 09m
Frontier
Deal found 6/15![Frontier logo]()
$130
This Booking.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1410:00 am
SAN
- DSM
1 stop25h 34m
Frontier
Deal found 6/14![Frontier logo]()
$141
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/98:51 pm
SAN
- DSM
1 stop22h 32m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$152
This Frontier deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/286:25 am
SAN
- DSM
1 stop5h 06m
Frontier
Deal found 6/12![Frontier logo]()
$155
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/84:38 pm
SAN
- DSM
2 stops26h 05m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$161
This Frontier deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:25 am
SAN
- DSM
1 stop5h 09m
Frontier
Deal found 6/12![Frontier logo]()
$164
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/144:12 pm
SAN
- DSM
2 stops18h 47m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$168
Find flight deals from San Diego to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from San Diego (SAN) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 16, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $261 (Kiwi.com) |
One-way from | $92 (Kiwi.com) |
Popular in | January |
Cheapest in | November |
Average price | $396 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Diego to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2026.
Use the filters below to find and compare flights from San Diego to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
San DiegoDes Moines
SAN - DSM
SANDSM
San Diego
Wed 9/2
6:20 am-4:19 pm
2 stops7h 59m
Des Moines
Mon 9/7
5:45 am-9:05 am
1 stop5h 20m
$395
San DiegoDes Moines
SAN - DSM
SANDSM
San Diego
Wed 8/12
6:20 am-4:19 pm
2 stops7h 59m
Des Moines
Sat 8/15
9:13 am-2:50 pm
1 stop7h 37m
$398
San DiegoDes Moines
SAN - DSM
SANDSM
San Diego
Thu 8/20
6:29 am-4:50 pm
1 stop8h 21m
Des Moines
Sun 8/23
5:56 pm-11:35 pm
1 stop7h 39m
$411
San DiegoDes Moines
SAN - DSM
SANDSM
San Diego
Tue 8/18
12:01 pm-10:30 pm
1 stop8h 29m
Des Moines
Wed 8/19
6:00 am-11:15 am
1 stop7h 15m
$437
Quickest round-trip
San DiegoDes Moines
SAN - DSM
SANDSM
San Diego
Thu 9/3
6:30 am-4:19 pm
1 stop7h 49m
Des Moines
Mon 9/7
5:45 am-9:05 am
1 stop5h 20m
$437
San DiegoDes Moines
SAN - DSM
SANDSM
San Diego
Fri 7/3
6:35 am-4:00 pm
1 stop7h 25m
Des Moines
Tue 7/7
6:25 am-12:40 pm
2 stops8h 15m
$473
Cheapest one-way
San DiegoDes Moines
SAN - DSM
SANDSM
San Diego
Tue 8/4
3:03 pm-12:59 pm
1 stop19h 56m
$92
San DiegoDes Moines
SAN - DSM
SANDSM
San Diego
Tue 7/21
3:03 pm-12:59 pm
1 stop19h 56m
$113
Quickest one-way
San DiegoDes Moines
SAN - DSM
SANDSM
San Diego
Wed 7/29
6:25 am-1:34 pm
1 stop5h 09m
$124
San DiegoDes Moines
SAN - DSM
SANDSM
San Diego
Thu 7/9
8:51 pm-9:23 pm
1 stop22h 32m
$152
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from San Diego to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Diego to Des Moines in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on San Diego-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Diego-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Diego-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Diego-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Diego-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Diego to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from San Diego with our price prediction graph.
SAN-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Diego to Des Moines
What is the cheapest month to book a flight from San Diego to Des Moines?
Currently, November is the cheapest month in which you can book a flight from San Diego to Des Moines (average of $253). Flying from San Diego to Des Moines in January is currently the most expensive (average of $593). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from San Diego to Des Moines?
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated June 16, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from San Diego to Des Moines to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Crew
8.6
Food
7.0
Boarding
8.1
Entertainment
7.5
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Comfort
8.0
Crew
8.6
Food
7.0
Boarding
8.1
Entertainment
7.5
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Comfort
8.0
Crew
8.6
Food
7.0
Boarding
8.1
Entertainment
7.5
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Comfort
8.0
Crew
8.6
Food
7.0
Boarding
8.1
Entertainment
7.5
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Comfort
8.0
Crew
8.6
Food
7.0
Boarding
8.1
Entertainment
7.5
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Comfort
8.0
Crew
8.6
Food
7.0
Boarding
8.1
Entertainment
7.5
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Related info for your journey
Find useful and relevant information for your journey from San Diego to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Ames
Johnston
Clive
Boone
West Des Moines
Ankeny
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San Diego and Des Moines flights
Browse other San Diego and Des Moines flight options. Last updated on June 16, 2026.
Other flights from San Diego
Browse through other flights departing from San Diego. Flights are based on user searches made on Cheapflights and were last updated on June 16, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 5 airlines flying from San Diego to Des Moines
Discover the top 5 airlines that operate flights from San Diego to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$148 | Average$336 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$158 | Average$270 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$247 | Average$499 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$296 | Average$395 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$296 | Average$462 | FlexibilityNo cancel fee | On-time71% |