$98+ Cheap flights from Fort Myers to Des Moines (RSW - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/18. Fares are subject to change and may not be available on all flights or dates of travel.
RSW — DSM
Oct 7 — Oct 141
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Fort Myers to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Fort Myers to Des Moines
Cheapest
Best
Last-minute
One-way
Cheapest flights from Fort Myers to Des MoinesExplore the most affordable flight options available from Fort Myers to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 7, 2026.
Explore the most affordable flight options available from Fort Myers to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 7, 2026.
This Super.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/187:53 pm -
Nonstop3h 15m
Fri 9/253:04 pm -
Nonstop2h 59m
Deal found 9/6![Allegiant Air logo]()
$98
This Trip.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/187:53 pm -
Nonstop3h 15m
Mon 9/2110:05 am -
Nonstop2h 59m
Deal found 9/6![Allegiant Air logo]()
$118
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/187:53 pm -
Nonstop3h 15m
Mon 9/214:59 pm -
2 stops38h 47m
Deal found 9/6![Multiple Airlines logo]()
$280
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1012:46 pm -
1 stop8h 11m
Mon 9/1410:05 am -
Nonstop2h 59m
Deal found 9/2![Multiple Airlines logo]()
$290
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/117:53 pm -
Nonstop3h 15m
Sun 9/131:58 pm -
1 stop20h 53m
Deal found 9/6![Multiple Airlines logo]()
$295
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/68:00 pm -
Nonstop3h 15m
Sun 11/812:25 pm -
2 stops33h 39m
Deal found 9/3![Multiple Airlines logo]()
$301
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/237:00 am -
2 stops28h 44m
Fri 9/253:04 pm -
Nonstop2h 59m
Deal found 9/2![Multiple Airlines logo]()
$303
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2412:46 pm -
1 stop8h 11m
Sun 9/271:58 pm -
1 stop20h 53m
Deal found 9/2![Multiple Airlines logo]()
$328
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2812:31 pm -
1 stop5h 24m
Thu 10/295:35 am -
1 stop5h 32m
Deal found 9/3![Delta logo]()
$339
Best flights from Fort Myers to Des MoinesDiscover carefully curated flight deals from Fort Myers to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 7, 2026.
Discover carefully curated flight deals from Fort Myers to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 7, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2412:46 pm -
1 stop8h 11m
Sun 9/271:58 pm -
1 stop20h 53m
Deal found 9/2![Multiple Airlines logo]()
$328
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2812:31 pm -
1 stop5h 24m
Thu 10/295:35 am -
1 stop5h 32m
Deal found 9/3![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:30 am -
2 stops9h 57m
Thu 10/299:50 am -
1 stop6h 12m
Deal found 9/3![United Airlines logo]()
$344
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/134:46 pm -
1 stop7h 55m
Tue 1/199:37 am -
1 stop8h 07m
Deal found 9/5![American Airlines logo]()
$403
This Southwest deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2312:20 pm -
2 stops10h 40m
Fri 9/255:40 am -
2 stops8h 25m
Deal found 9/2![Southwest logo]()
$474
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/232:41 pm -
3 stops30h 16m
Fri 9/253:04 pm -
Nonstop2h 59m
Deal found 9/2![Multiple Airlines logo]()
$334
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/134:15 pm -
1 stop5h 37m
Tue 1/1910:15 am -
1 stop6h 07m
Deal found 9/3![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/12:07 pm -
2 stops10h 41m
Sun 10/46:00 am -
1 stop6h 01m
Deal found 9/6![United Airlines logo]()
$445
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/264:45 pm -
1 stop6h 10m
Fri 10/301:27 pm -
1 stop7h 29m
Deal found 9/3![United Airlines logo]()
$452
Last-minute flights from Fort Myers to Des MoinesDiscover last-minute flight deals from Fort Myers to Des Moines. Data last updated September 7, 2026 and is based on user searches.
Discover last-minute flight deals from Fort Myers to Des Moines. Data last updated September 7, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1012:46 pm -
1 stop8h 11m
Mon 9/1410:05 am -
Nonstop2h 59m
Deal found 9/2![Multiple Airlines logo]()
$290
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/117:53 pm -
Nonstop3h 15m
Sun 9/131:58 pm -
1 stop20h 53m
Deal found 9/6![Multiple Airlines logo]()
$295
This Super.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/187:53 pm -
Nonstop3h 15m
Fri 9/253:04 pm -
Nonstop2h 59m
Deal found 9/6![Allegiant Air logo]()
$98
This Trip.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/187:53 pm -
Nonstop3h 15m
Mon 9/2110:05 am -
Nonstop2h 59m
Deal found 9/6![Allegiant Air logo]()
$118
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/187:53 pm -
Nonstop3h 15m
Mon 9/214:59 pm -
2 stops38h 47m
Deal found 9/6![Multiple Airlines logo]()
$280
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/237:00 am -
2 stops28h 44m
Fri 9/253:04 pm -
Nonstop2h 59m
Deal found 9/2![Multiple Airlines logo]()
$303
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2412:46 pm -
1 stop8h 11m
Sun 9/271:58 pm -
1 stop20h 53m
Deal found 9/2![Multiple Airlines logo]()
$328
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2812:31 pm -
1 stop5h 24m
Thu 10/295:35 am -
1 stop5h 32m
Deal found 9/3![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:30 am -
2 stops9h 57m
Thu 10/299:50 am -
1 stop6h 12m
Deal found 9/3![United Airlines logo]()
$344
One-way flights from Fort Myers to Des MoinesSearch for one-way flight options from Fort Myers to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 7, 2026.
Search for one-way flight options from Fort Myers to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 7, 2026.
This Super.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/282:54 pm -
Nonstop3h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Allegiant Air logo]()
$126
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:30 am -
1 stop6h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Delta logo]()
$170
This Frontier deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2212:36 pm -
1 stop8h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Frontier logo]()
$173
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2012:16 pm -
2 stops10h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![United Airlines logo]()
$175
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/201:11 pm -
3 stops50h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Multiple Airlines logo]()
$201
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/178:18 am -
1 stop6h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![American Airlines logo]()
$202
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/172:14 pm -
2 stops10h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![United Airlines logo]()
$207
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2610:15 am -
2 stops8h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Southwest logo]()
$211
This Delta deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/12:39 pm -
1 stop7h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Delta logo]()
$212
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1712:25 pm -
3 stops27h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Multiple Airlines logo]()
$215
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:00 am -
3 stops35h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Multiple Airlines logo]()
$218
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2211:50 am -
1 stop8h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![American Airlines logo]()
$219
Find flight deals from Fort Myers to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Fort Myers (RSW) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 7, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $118 (Trip.com) |
Popular in | March |
Cheapest in | December |
Average price | $338 |
Cheapflights Fare Finder
Customize your flight search to find flights from Fort Myers to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 7, 2026.
Use the filters below to find and compare flights from Fort Myers to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Fort MyersDes Moines
RSW Fort Myers SW Florida Intl - DSM Des Moines
RSWDSM
Fort Myers SW Florida Intl
Sat 9/12
5:30 am-10:46 am
1 stop6h 16m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$170
Fort MyersDes Moines
RSW Fort Myers SW Florida Intl - DSM Des Moines
RSWDSM
Fort Myers SW Florida Intl
Tue 10/20
8:45 am-2:15 pm
1 stop6h 30m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$170
Fort MyersDes Moines
RSW Fort Myers SW Florida Intl - DSM Des Moines
RSWDSM
Fort Myers SW Florida Intl
Wed 10/28
5:30 am-10:42 am
1 stop6h 12m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$170
Fort MyersDes Moines
RSW Fort Myers SW Florida Intl - DSM Des Moines
RSWDSM
Fort Myers SW Florida Intl
Sat 11/7
5:11 pm-12:26 am
1 stop8h 15m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$202
Fort MyersDes Moines
RSW Fort Myers SW Florida Intl - DSM Des Moines
RSWDSM
Fort Myers SW Florida Intl
Sat 10/17
2:14 pm-11:52 pm
2 stops10h 38m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$207
Fort MyersDes Moines
RSW Fort Myers SW Florida Intl - DSM Des Moines
RSWDSM
Fort Myers SW Florida Intl
Thu 11/26
10:15 am-5:15 pm
2 stops8h 00m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$211
Fort MyersDes Moines
RSW Fort Myers SW Florida Intl - DSM Des Moines
RSWDSM
Fort Myers SW Florida Intl
Sat 9/12
12:09 pm-10:55 pm
2 stops11h 46m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$220
Fort MyersDes Moines
RSW Fort Myers SW Florida Intl - DSM Des Moines
RSWDSM
Fort Myers SW Florida Intl
Sun 11/22
12:35 pm-9:55 pm
2 stops10h 20m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$224
Quickest round-trip
Fort MyersDes Moines
RSW Fort Myers SW Florida Intl - DSM Des Moines
RSWDSM
Fort Myers SW Florida Intl
Sun 12/27
1:20 pm-6:01 pm
1 stop5h 41m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$239
Fort MyersDes Moines
RSW Fort Myers SW Florida Intl - DSM Des Moines
RSWDSM
Fort Myers SW Florida Intl
Thu 10/1
2:07 pm-11:48 pm
2 stops10h 41m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$252
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from Fort Myers to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Fort Myers to Des Moines in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Fort Myers-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Fort Myers-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Fort Myers-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Fort Myers-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Fort Myers-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Fort Myers to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Fort Myers with our price prediction graph.
RSW-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Fort Myers to Des Moines
What is the cheapest month to book a flight from Fort Myers to Des Moines?
Currently, December is the cheapest month in which you can book a flight from Fort Myers to Des Moines (average of $140). Flying from Fort Myers to Des Moines in March is currently the most expensive (average of $508). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from RSW to DSM?
Find hourly flight availability from Fort Myers to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 7, 2026.
When flying from Fort Myers to Des Moines, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated September 7, 2026.
Peruse reviews from past customers who have flown with Delta,Allegiant Air, andAmerican Airlines from Fort Myers to Des Moines to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Crew
8.5
Food
7.2
Boarding
8.1
Overall
7.8
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Comfort
7.8
Crew
8.5
Food
7.2
Boarding
8.1
Overall
7.8
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Comfort
7.8
Crew
8.5
Food
7.2
Boarding
8.1
Overall
7.8
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Comfort
7.8
Crew
8.5
Food
7.2
Boarding
8.1
Overall
7.8
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
Find useful and relevant information for your journey from Fort Myers to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
Ames
Johnston
Boone
Norwalk
West Des Moines
Ankeny
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Des Moines flight routes
Flights by cabin class
Other flight options
Popular flights
Alternative routes for Fort Myers to Des Moines
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Des Moines by adding a car rental and/or hotel reservation to your travel itinerary.
Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 7, 2026.
Search flights from Fort Myers to Des Moines by cabin class
Find flights from Fort Myers to Des Moines, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Fort Myers and Des Moines flights
Browse other Fort Myers and Des Moines flight options. Last updated on September 7, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Fort Myers to Des Moines
Discover the top 3 airlines that operate flights from Fort Myers to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 7, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$94 | Average$189 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$152 | Average$428 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$236 | Average$441 | FlexibilityNo cancel fee | On-time71% |