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Des Moines

$119+ Cheap flights from Fort Myers to Des Moines (RSW - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/16. Fares are subject to change and may not be available on all flights or dates of travel.
RSW — DSM
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
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Find flight deals from Fort Myers to Des Moines

Cheapest flights from Fort Myers to Des Moines
Explore the most affordable flight options available from Fort Myers to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/216:50 pmRSW - DSM
Nonstop3h 19mMultiple Airlines
Tue 11/254:03 pmDSM - RSW
2 stops22h 08mMultiple Airlines
Deal found 11/6$215
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/126:50 pmRSW - DSM
Nonstop3h 19mMultiple Airlines
Sun 12/142:56 pmDSM - RSW
2 stops24h 54mMultiple Airlines
Deal found 11/5$221
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2211:42 amRSW - DSM
1 stop5h 59mAmerican Airlines
Tue 11/255:00 amDSM - RSW
1 stop6h 02mAmerican Airlines
Deal found 11/4$412
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/35:05 pmRSW - DSM
1 stop6h 24mUnited Airlines
Wed 12/1011:35 amDSM - RSW
1 stop7h 21mUnited Airlines
Deal found 11/5$415
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/125:45 pmRSW - DSM
2 stops6h 50mSouthwest
Sun 12/145:45 amDSM - RSW
2 stops10h 30mSouthwest
Deal found 11/5$437
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/225:38 pmRSW - DSM
1 stop5h 55mDelta
Tue 11/253:30 pmDSM - RSW
1 stop7h 20mDelta
Deal found 11/5$487
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2212:15 pmRSW - DSM
2 stops10h 17mUnited Airlines
Tue 11/258:02 amDSM - RSW
1 stop5h 40mUnited Airlines
Deal found 11/5$492
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2011:41 amRSW - DSM
2 stops13h 03mUnited Airlines
Mon 11/2411:26 amDSM - RSW
2 stops11h 12mUnited Airlines
Deal found 11/5$518

Cheap flight deals from Fort Myers to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Fort Myers (RSW) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 6, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$215
(Kiwi.com)

One-way from

$119
(American Airlines)

Popular in

October

Cheapest in

August

Average price

$393
Provider with most accurate pricing for Fort Myers SW Florida Intl-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Fort Myers SW Florida Intl-Des Moines flights.
Search Deals
From Fort Myers SW Florida Intl to Des Moines
Search Deals
One-way flight from Fort Myers SW Florida Intl to Des Moines
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($54 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($24 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Fort Myers to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Fort Myers to Des Moines that are best for you.

Fly from

Fort Myers

Fly to

Des Moines

Route

Depart

Return

Price

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Fri 11/21

6:50 pm-9:09 pm

Nonstop3h 19m

Des Moines

Tue 11/25

4:03 pm-3:11 pm

2 stops22h 08m

$215

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Fri 12/12

6:50 pm-9:09 pm

Nonstop3h 19m

Des Moines

Sun 12/14

2:56 pm-4:50 pm

2 stops24h 54m

$221

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Fri 2/27

6:00 am-1:16 pm

1 stop8h 16m

Des Moines

Sun 3/1

11:26 am-8:30 pm

1 stop8h 04m

$261

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Fri 1/2

6:54 pm-9:13 pm

Nonstop3h 19m

Des Moines

Sun 1/4

9:31 am-10:18 am

2 stops23h 47m

$397

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 3/5

4:15 pm-8:49 pm

1 stop5h 34m

Des Moines

Mon 3/9

5:15 pm-12:37 am

1 stop6h 22m

$407

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Sat 11/22

11:42 am-4:41 pm

1 stop5h 59m

Des Moines

Tue 11/25

5:00 am-12:02 pm

1 stop6h 02m

$412

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Wed 12/3

5:05 pm-10:29 pm

1 stop6h 24m

Des Moines

Wed 12/10

11:35 am-7:56 pm

1 stop7h 21m

$415

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Tue 12/16

8:34 am-4:25 pm

2 stops8h 51m

$124

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 11/13

6:00 am-2:55 pm

2 stops33h 55m

$153

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Sat 1/10

6:50 am-12:17 pm

1 stop6h 27m

$169

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/5

Showing 1-10 of 13 results
1
2

Compare providers for flights from Fort Myers to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Fort Myers to Des Moines in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Fort Myers-Des Moines flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Fort Myers-Des Moines flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Fort Myers-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Fort Myers-Des Moines flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Fort Myers-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Fort Myers to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Fort Myers with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Fort Myers to Des Moines

What is the cheapest month to book a flight from Fort Myers to Des Moines?

Currently, November is the cheapest month in which you can book a flight from Fort Myers to Des Moines (average of $93). Flying from Fort Myers to Des Moines in May is currently the most expensive (average of $434). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from RSW to DSM?

Find hourly flight availability from Fort Myers to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 6, 2025.

One of the essential ways to save on airfare from Fort Myers to Des Moines is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the afternoon could potentially save you up to 62% on airfare.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated November 6, 2025.
Peruse reviews from past customers who have flown with Southwest and American Airlines from Fort Myers to Des Moines to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,241 reviews

Crew

8.6

Food

7.0

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,241 reviews
Southwest
8.0
Very good
4,241 reviews

Crew

8.6

Food

7.0

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,040 reviews
Southwest
8.0
Very good
4,241 reviews

Crew

8.6

Food

7.0

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Fort Myers to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Fort Myers to Des Moines?

    There are many flights that can get you from Fort Myers to Des Moines in 8h 16m. Fly via American Airlines to get the fastest option. The distance between Fort Myers and Des Moines is about 1237 mi.

  • What are the cheapest airlines flying from Fort Myers to Des Moines round-trip?

    American Airlines, at $266, was found to be the cheapest airline from Fort Myers to Des Moines. An alternate airline flying to your destination would be Southwest. You may be able to fly from Fort Myers to Des Moines for 36% less than the average price by searching for these airlines.

  • Can I find deals for flights from Fort Myers to Des Moines that include hotel bookings?

    Yes. In addition to deals on Fort Myers to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Fort Myers to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Fort Myers to Des Moines.

  • Can I find deals for business class flights from Fort Myers to Des Moines?

    Yes. Cheapflights offers flight deals from Fort Myers to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Fort Myers to Des Moines?

    Currently, November is the cheapest month in which you can book a flight from Fort Myers to Des Moines (average of $93). Flying from Fort Myers to Des Moines in May is currently the most expensive (average of $434). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Top 2 airlines flying from Fort Myers to Des Moines

Discover the top 2 airlines that operate flights from Fort Myers to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$266Average$343FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$346Average$388FlexibilityNo cancel feeOn-time63%

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