$348+ Cheap flights from Gainesville to Des Moines (GNV - DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/12. Fares are subject to change and may not be available on all flights or dates of travel.
GNV — DSM
Jun 29 — Jul 61
Round-trip
1 adult, Economy
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Find cheap flights from Gainesville to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Gainesville to Des Moines
Cheapest
Best
Last-minute
One-way
Cheapest flights from Gainesville to Des MoinesExplore the most affordable flight options available from Gainesville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 30, 2026.
Explore the most affordable flight options available from Gainesville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 30, 2026.
This Delta deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2110:17 am
GNV
- DSM
1 stop4h 17m
Delta
Wed 8/55:40 am
DSM
- GNV
1 stop5h 43m
Delta
Deal found 5/25![Delta logo]()
$377
This Delta deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/236:33 am
GNV
- DSM
1 stop5h 12m
Delta
Sat 8/15:41 am
DSM
- GNV
1 stop5h 42m
Delta
Deal found 5/25![Delta logo]()
$422
This American Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/247:32 pm
GNV
- DSM
1 stop5h 37m
American Airlines
Tue 8/44:48 pm
DSM
- GNV
1 stop5h 38m
American Airlines
Deal found 5/25![American Airlines logo]()
$429
This Delta deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2110:17 am
GNV
- DSM
1 stop4h 17m
Delta
Tue 8/45:40 am
DSM
- GNV
1 stop5h 43m
Delta
Deal found 5/25![Delta logo]()
$458
This American Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/215:21 pm
GNV
- DSM
1 stop7h 37m
American Airlines
Tue 8/42:41 pm
DSM
- GNV
2 stops8h 18m
American Airlines
Deal found 5/25![American Airlines logo]()
$472
This American Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/221:48 pm
GNV
- DSM
2 stops11h 13m
American Airlines
Wed 8/52:21 pm
DSM
- GNV
2 stops8h 41m
American Airlines
Deal found 5/25![American Airlines logo]()
$477
This Delta deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/217:01 pm
GNV
- DSM
2 stops16h 12m
Delta
Sat 8/15:41 am
DSM
- GNV
1 stop5h 42m
Delta
Deal found 5/25![Delta logo]()
$503
This Delta deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2110:17 am
GNV
- DSM
1 stop4h 17m
Delta
Fri 8/72:54 pm
DSM
- GNV
1 stop20h 29m
Delta
Deal found 5/25![Delta logo]()
$512
This Delta deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/2510:17 am
GNV
- DSM
2 stops11h 51m
Delta
Wed 8/55:40 am
DSM
- GNV
1 stop5h 43m
Delta
Deal found 5/25![Delta logo]()
$517
This American Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:00 am
GNV
- DSM
2 stops11h 00m
American Airlines
Wed 8/52:21 pm
DSM
- GNV
2 stops8h 41m
American Airlines
Deal found 5/25![American Airlines logo]()
$526
Best flights from Gainesville to Des MoinesDiscover carefully curated flight deals from Gainesville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 30, 2026.
Discover carefully curated flight deals from Gainesville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 30, 2026.
This Delta deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/246:33 am
GNV
- DSM
1 stop5h 12m
Delta
Sat 8/15:41 am
DSM
- GNV
1 stop5h 42m
Delta
Deal found 5/25![Delta logo]()
$422
This Delta deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/236:33 am
GNV
- DSM
1 stop5h 12m
Delta
Sat 8/15:41 am
DSM
- GNV
1 stop5h 42m
Delta
Deal found 5/25![Delta logo]()
$422
This Delta deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:33 am
GNV
- DSM
1 stop5h 12m
Delta
Tue 8/411:28 am
DSM
- GNV
1 stop5h 48m
Delta
Deal found 5/25![Delta logo]()
$458
This Delta deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/227:01 pm
GNV
- DSM
1 stop4h 28m
Delta
Fri 8/75:40 am
DSM
- GNV
1 stop16h 08m
Delta
Deal found 5/25![Delta logo]()
$512
This Delta deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/266:33 am
GNV
- DSM
1 stop5h 12m
Delta
Thu 8/62:54 pm
DSM
- GNV
1 stop17h 29m
Delta
Deal found 5/25![Delta logo]()
$557
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/246:33 am
GNV
- DSM
1 stop5h 10m
Delta
Sat 6/275:35 am
DSM
- GNV
1 stop5h 50m
Delta
Deal found 5/28![Delta logo]()
$680
This Delta deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/187:04 pm
GNV
- DSM
1 stop4h 27m
Delta
Sun 6/215:35 am
DSM
- GNV
1 stop5h 50m
Delta
Deal found 5/25![Delta logo]()
$762
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/1510:17 am
GNV
- DSM
1 stop4h 18m
Delta
Fri 6/195:35 am
DSM
- GNV
1 stop5h 50m
Delta
Deal found 5/28![Delta logo]()
$795
This Delta deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/236:33 am
GNV
- DSM
2 stops8h 32m
Delta
Mon 8/310:59 am
DSM
- GNV
2 stops10h 49m
Delta
Deal found 5/25![Delta logo]()
$1,287
Last-minute flights from Gainesville to Des MoinesDiscover last-minute flight deals from Gainesville to Des Moines. Data last updated May 30, 2026 and is based on user searches.
Discover last-minute flight deals from Gainesville to Des Moines. Data last updated May 30, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/1510:17 am
GNV
- DSM
1 stop4h 18m
Delta
Fri 6/195:35 am
DSM
- GNV
1 stop5h 50m
Delta
Deal found 5/28![Delta logo]()
$795
This Delta deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/187:04 pm
GNV
- DSM
1 stop4h 27m
Delta
Sun 6/215:35 am
DSM
- GNV
1 stop5h 50m
Delta
Deal found 5/25![Delta logo]()
$762
This Delta deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/216:33 am
GNV
- DSM
1 stop5h 10m
Delta
Wed 6/245:35 am
DSM
- GNV
1 stop5h 50m
Delta
Deal found 5/25![Delta logo]()
$705
This American Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/217:32 pm
GNV
- DSM
1 stop5h 40m
American Airlines
Wed 6/241:51 pm
DSM
- GNV
2 stops9h 42m
American Airlines
Deal found 5/25![American Airlines logo]()
$710
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/246:33 am
GNV
- DSM
1 stop5h 10m
Delta
Sat 6/275:35 am
DSM
- GNV
1 stop5h 50m
Delta
Deal found 5/28![Delta logo]()
$680
One-way flights from Gainesville to Des MoinesSearch for one-way flight options from Gainesville to Des Moines. Find affordable one-way fares based on user searches. Data last updated May 30, 2026.
Search for one-way flight options from Gainesville to Des Moines. Find affordable one-way fares based on user searches. Data last updated May 30, 2026.
This Delta deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/1210:17 am
GNV
- DSM
1 stop4h 17m
Delta
Deal found 5/26![Delta logo]()
$348
This Delta deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/25:22 pm
GNV
- DSM
1 stop6h 09m
Delta
Deal found 5/26![Delta logo]()
$398
This American Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/286:15 am
GNV
- DSM
2 stops9h 57m
American Airlines
Deal found 5/28![American Airlines logo]()
$403
Find flight deals from Gainesville to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Gainesville (GNV) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $377 (Delta) |
One-way from | $348 (Delta) |
Cheapflights Fare Finder
Customize your flight search to find flights from Gainesville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 30, 2026.
Use the filters below to find and compare flights from Gainesville to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GainesvilleDes Moines
GNV - DSM
GNVDSM
Gainesville Regional
Fri 7/24
6:33 am-10:45 am
1 stop5h 12m
Des Moines
Sat 8/1
5:41 am-12:23 pm
1 stop5h 42m
$422
GainesvilleDes Moines
GNV - DSM
GNVDSM
Gainesville Regional
Thu 7/23
6:33 am-10:45 am
1 stop5h 12m
Des Moines
Sat 8/1
5:41 am-12:23 pm
1 stop5h 42m
$422
GainesvilleDes Moines
GNV - DSM
GNVDSM
Gainesville Regional
Wed 7/22
6:33 am-10:45 am
1 stop5h 12m
Des Moines
Tue 8/4
11:28 am-6:16 pm
1 stop5h 48m
$458
GainesvilleDes Moines
GNV - DSM
GNVDSM
Gainesville Regional
Wed 7/22
7:01 pm-10:29 pm
1 stop4h 28m
Des Moines
Fri 8/7
5:40 am-10:48 pm
1 stop16h 08m
$512
GainesvilleDes Moines
GNV - DSM
GNVDSM
Gainesville Regional
Sun 7/26
6:33 am-10:45 am
1 stop5h 12m
Des Moines
Thu 8/6
2:54 pm-9:23 am
1 stop17h 29m
$557
GainesvilleDes Moines
GNV - DSM
GNVDSM
Gainesville Regional
Wed 6/24
6:33 am-10:43 am
1 stop5h 10m
Des Moines
Sat 6/27
5:35 am-12:25 pm
1 stop5h 50m
$680
GainesvilleDes Moines
GNV - DSM
GNVDSM
Gainesville Regional
Thu 6/18
7:04 pm-10:31 pm
1 stop4h 27m
Des Moines
Sun 6/21
5:35 am-12:25 pm
1 stop5h 50m
$762
Quickest round-trip
GainesvilleDes Moines
GNV - DSM
GNVDSM
Gainesville Regional
Mon 6/15
10:17 am-1:35 pm
1 stop4h 18m
Des Moines
Fri 6/19
5:35 am-12:25 pm
1 stop5h 50m
$795
GainesvilleDes Moines
GNV - DSM
GNVDSM
Gainesville Regional
Thu 7/23
6:33 am-2:05 pm
2 stops8h 32m
Des Moines
Mon 8/3
10:59 am-10:48 pm
2 stops10h 49m
$1,287
Cheapest one-way
Quickest one-way
GainesvilleDes Moines
GNV - DSM
GNVDSM
Gainesville Regional
Fri 8/28
2:51 pm-6:41 pm
1 stop4h 50m
$348
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from Gainesville to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Gainesville to Des Moines in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Gainesville-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Gainesville-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Gainesville-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Gainesville-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Gainesville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Gainesville to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Gainesville with our price prediction graph.
GNV-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated May 30, 2026.
See what other customers who have flown with American Airlines from Gainesville to Des Moines have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.5
Comfort
7.2
Entertainment
6.9
Overall
7.1
Food
6.4
Crew
7.9
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Boarding
7.5
Comfort
7.2
Entertainment
6.9
Overall
7.1
Food
6.4
Crew
7.9
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Related info for your journey
Find useful and relevant information for your journey from Gainesville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Johnston
Ames
Clive
Boone
West Des Moines
Ankeny
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Gainesville and Des Moines flights
Browse other Gainesville and Des Moines flight options. Last updated on May 30, 2026.
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Top airline flying from Gainesville to Des Moines
Discover the top airline that operate flights from Gainesville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$394 | Average$1,129 | FlexibilityNo cancel fee | On-time71% |