$363+ Cheap flights from Des Moines to Gainesville (DSM - GNV)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/7. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GNV
Nov 6 — Nov 131
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Gainesville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Gainesville
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Cheapest flights from Des Moines to GainesvilleExplore the most affordable flight options available from Des Moines to Gainesville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 7, 2026.
Explore the most affordable flight options available from Des Moines to Gainesville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 7, 2026.
This Delta deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/244:07 pm -
1 stop4h 28m
Wed 10/287:03 pm -
1 stop4h 30m
Deal found 10/3![Delta logo]()
$505
This Delta deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/263:03 pm -
1 stop6h 40m
Sat 10/3110:19 am -
1 stop5h 57m
Deal found 10/3![Delta logo]()
$511
This American Airlines deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3011:22 am -
1 stop6h 30m
Thu 11/57:34 pm -
1 stop5h 23m
Deal found 10/3![American Airlines logo]()
$573
This American Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:08 am -
1 stop5h 13m
Sun 11/16:20 am -
1 stop5h 21m
Deal found 10/6![American Airlines logo]()
$576
This Delta deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:54 pm -
1 stop13h 40m
Sat 11/75:00 pm -
1 stop6h 33m
Deal found 10/3![Delta logo]()
$597
This Delta deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:54 pm -
1 stop13h 40m
Wed 11/46:03 am -
2 stops9h 22m
Deal found 10/3![Delta logo]()
$602
This Delta deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/273:03 pm -
1 stop6h 40m
Sun 11/11:33 pm -
1 stop22h 09m
Deal found 10/3![Delta logo]()
$626
Best flights from Des Moines to GainesvilleDiscover carefully curated flight deals from Des Moines to Gainesville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 7, 2026.
Discover carefully curated flight deals from Des Moines to Gainesville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 7, 2026.
This Delta deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/244:07 pm -
1 stop4h 28m
Wed 10/287:03 pm -
1 stop4h 30m
Deal found 10/3![Delta logo]()
$505
This American Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:08 am -
1 stop5h 13m
Sun 11/16:20 am -
1 stop5h 21m
Deal found 10/6![American Airlines logo]()
$576
This Delta deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/265:35 am -
1 stop6h 13m
Sat 10/316:03 am -
2 stops9h 22m
Deal found 10/3![Delta logo]()
$516
This Delta deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:54 pm -
1 stop13h 40m
Sat 11/75:00 pm -
1 stop6h 33m
Deal found 10/3![Delta logo]()
$597
This Delta deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:54 pm -
1 stop13h 40m
Wed 11/46:03 am -
2 stops9h 22m
Deal found 10/3![Delta logo]()
$602
This Delta deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:54 pm -
1 stop13h 40m
Fri 11/66:03 am -
1 stop5h 39m
Deal found 10/3![Delta logo]()
$642
This Delta deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/275:35 am -
1 stop6h 10m
Fri 10/307:03 pm -
1 stop21h 13m
Deal found 10/3![Delta logo]()
$646
This Delta deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/265:35 am -
1 stop6h 13m
Fri 10/307:03 pm -
1 stop16h 39m
Deal found 10/3![Delta logo]()
$652
This Delta deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2611:27 am -
1 stop5h 47m
Thu 10/294:02 pm -
1 stop7h 31m
Deal found 10/3![Delta logo]()
$745
Last-minute flights from Des Moines to GainesvilleDiscover last-minute flight deals from Des Moines to Gainesville. Data last updated October 7, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Gainesville. Data last updated October 7, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/244:07 pm -
1 stop4h 28m
Wed 10/287:03 pm -
1 stop4h 30m
Deal found 10/3![Delta logo]()
$505
This Delta deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/263:03 pm -
1 stop6h 40m
Sat 10/3110:19 am -
1 stop5h 57m
Deal found 10/3![Delta logo]()
$511
This Delta deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/273:03 pm -
1 stop6h 40m
Sun 11/11:33 pm -
1 stop22h 09m
Deal found 10/3![Delta logo]()
$626
This American Airlines deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3011:22 am -
1 stop6h 30m
Thu 11/57:34 pm -
1 stop5h 23m
Deal found 10/3![American Airlines logo]()
$573
This American Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:08 am -
1 stop5h 13m
Sun 11/16:20 am -
1 stop5h 21m
Deal found 10/6![American Airlines logo]()
$576
This Delta deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:54 pm -
1 stop13h 40m
Sat 11/75:00 pm -
1 stop6h 33m
Deal found 10/3![Delta logo]()
$597
This Delta deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:54 pm -
1 stop13h 40m
Wed 11/46:03 am -
2 stops9h 22m
Deal found 10/3![Delta logo]()
$602
One-way flights from Des Moines to GainesvilleSearch for one-way flight options from Des Moines to Gainesville. Find affordable one-way fares based on user searches. Data last updated October 7, 2026.
Search for one-way flight options from Des Moines to Gainesville. Find affordable one-way fares based on user searches. Data last updated October 7, 2026.
This American Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/711:09 am -
1 stop6h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![American Airlines logo]()
$363
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/710:30 am -
2 stops11h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![Delta logo]()
$368
Find flight deals from Des Moines to Gainesville
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Gainesville (GNV). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 7, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $505 (Delta) |
One-way from | $363 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Gainesville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 7, 2026.
Use the filters below to find and compare flights from Des Moines to Gainesville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesGainesville
DSM Des Moines - GNV Gainesville Regional
DSMGNV
Des Moines
Mon 12/7
10:30 am-10:54 pm
2 stops11h 24m
Gainesville Regional
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$368
Des MoinesGainesville
DSM Des Moines - GNV Gainesville Regional
DSMGNV
Des Moines
Mon 12/7
5:24 am-6:09 pm
2 stops11h 45m
Gainesville Regional
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$418
Quickest round-trip
Des MoinesGainesville
DSM Des Moines - GNV Gainesville Regional
DSMGNV
Des Moines
Sat 10/24
4:07 pm-9:35 pm
1 stop4h 28m
Gainesville Regional
Wed 10/28
7:03 pm-10:33 pm
1 stop4h 30m
$505
Des MoinesGainesville
DSM Des Moines - GNV Gainesville Regional
DSMGNV
Des Moines
Mon 10/26
5:35 am-12:48 pm
1 stop6h 13m
Gainesville Regional
Sat 10/31
6:03 am-2:25 pm
2 stops9h 22m
$516
Des MoinesGainesville
DSM Des Moines - GNV Gainesville Regional
DSMGNV
Des Moines
Fri 10/30
7:08 am-1:21 pm
1 stop5h 13m
Gainesville Regional
Sun 11/1
6:20 am-10:41 am
1 stop5h 21m
$576
Des MoinesGainesville
DSM Des Moines - GNV Gainesville Regional
DSMGNV
Des Moines
Fri 10/30
6:54 pm-9:34 am
1 stop13h 40m
Gainesville Regional
Sat 11/7
5:00 pm-10:33 pm
1 stop6h 33m
$597
Des MoinesGainesville
DSM Des Moines - GNV Gainesville Regional
DSMGNV
Des Moines
Fri 10/30
6:54 pm-9:34 am
1 stop13h 40m
Gainesville Regional
Wed 11/4
6:03 am-2:25 pm
2 stops9h 22m
$602
Des MoinesGainesville
DSM Des Moines - GNV Gainesville Regional
DSMGNV
Des Moines
Fri 10/30
6:54 pm-9:34 am
1 stop13h 40m
Gainesville Regional
Fri 11/6
6:03 am-10:42 am
1 stop5h 39m
$642
Des MoinesGainesville
DSM Des Moines - GNV Gainesville Regional
DSMGNV
Des Moines
Tue 10/27
5:35 am-12:45 pm
1 stop6h 10m
Gainesville Regional
Fri 10/30
7:03 pm-3:16 pm
1 stop21h 13m
$646
Des MoinesGainesville
DSM Des Moines - GNV Gainesville Regional
DSMGNV
Des Moines
Mon 10/26
5:35 am-12:48 pm
1 stop6h 13m
Gainesville Regional
Fri 10/30
7:03 pm-10:42 am
1 stop16h 39m
$652
Showing 1-10 of 11 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Gainesville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Gainesville in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Gainesville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Gainesville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Gainesville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Gainesville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Gainesville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Gainesville
Have a flexible travel schedule? Discover the best time to fly to Gainesville from Des Moines with our price prediction graph.
DSM-GNV
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Gainesville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Gainesville?
Book flights to Gainesville if you plan to visit one of these locationsLake City
Alachua
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