What are the cheapest airlines flying from Des Moines to San Francisco round-trip?

Our cheapest airline available from Des Moines to San Francisco is Frontier. Our recent data shows that you can find tickets from as low as $190 on this airline. Additional options worth looking into are Delta and American Airlines, starting at $313 and $332 round-trip. Frontier is currently priced 57% below the average price you’ll pay for this route.

What are the cheapest airlines to fly from Des Moines to San Francisco one-way?

The cheapest airline one-way is Frontier, with whom users have recently found tickets for as low as $117. However, be on the lookout for offers from American Airlines and United Airlines, as they are both options that can get you from Des Moines to San Francisco for a low price.

What are the most popular airlines that fly from Des Moines to San Francisco?

The most popular airlines flying from Des Moines to San Francisco are American Airlines, Delta and Frontier. Something to consider prior to booking your flight.

What is the cheapest day to fly round-trip from Des Moines to San Francisco?

Users have found that flying from Des Moines to San Francisco on a Saturday typically leans towards higher prices. However, this doesn’t mean you still can’t find a deal. Flexibility with other aspects of your flight can still land a great price for your trip.

How far in advance should I book a flight from Des Moines to San Francisco?

Users have found that booking a flight from Des Moines to San Francisco at least 17 days early can save you up to 450% on average compared to booking a flight this week. If booking 17 days before your flight isn’t an option for you, users have found flights from Des Moines to San Francisco for as little as $348 when booking for a departure date within the next two weeks. You can also check prices now. Some users have found airline tickets as low as $616 for flights departing within the next 3 days.

What is the cheapest month to fly from Des Moines to San Francisco?

Flights from Des Moines to San Francisco lean towards being more expensive in June. Prices are generally better when you fly from Des Moines to San Francisco in September, with the cheapest ticket starting at $145.

Most accurate provider : When it comes to deals on Des Moines-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Francisco flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Des Moines-San Francisco flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Des Moines to San Francisco that include hotel bookings?

Yes. In addition to deals on Des Moines to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to San Francisco.

Can I find deals for business class flights from Des Moines to San Francisco?

Yes. Cheapflights offers flight deals from Des Moines to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$117+ Flights from Des Moines to San Francisco

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from Des Moines to San Francisco with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Des Moines to San Francisco are usually found in September or August, booked 16 days in advance, depart on a Wednesday or Friday and return on a Wednesday

Cheap flight deals from Des Moines to San Francisco

Most accurate provider	FlightHub 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$190 (Trip.com)
One-way from	$117 (CheapOair)
Popular in	June
Cheapest in	September
Average price	$458

Provider with most accurate pricing for Des Moines-San Francisco flight deals.

Search Deals

Provider most trusted by Cheapflights users for Des Moines-San Francisco flights.

Search Deals

From Des Moines to San Francisco

Search Deals

One-way flight from Des Moines to San Francisco

Search Deals

Highest demand for flights based on searches. 7% potential increase in price ($35 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in April 2025

Search Deals

Find flight deals from Des Moines to San Francisco

Cheapest flights from Des Moines to San Francisco
Explore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 25, 2025.

Mon 5/57:20 pmDSM - SFO

1 stop21h 24mFrontier

Wed 5/76:35 amSFO - DSM

1 stop9h 55mFrontier

Deal found 4/24

$190

Wed 8/132:53 pmDSM - SFO

1 stop7h 38mDelta

Tue 8/1912:40 amSFO - DSM

1 stop7h 26mDelta

Deal found 4/25

$313

Tue 5/275:27 pmDSM - SFO

1 stop8h 55mAmerican Airlines

Sat 5/3111:49 pmSFO - DSM

1 stop9h 24mAmerican Airlines

Deal found 4/25

$332

Wed 8/136:30 amDSM - SFO

1 stop5h 35mSouthwest

Wed 8/209:55 amSFO - DSM

2 stops9h 30mSouthwest

Deal found 4/24

$356

Sun 6/810:27 pmDSM - SFO

1 stop24h 54mMultiple Airlines

Sun 6/1510:33 amSFO - DSM

2 stops34h 01mMultiple Airlines

Deal found 4/24

$372

Fri 9/58:00 amDSM - SFO

2 stops13h 05mUnited Airlines

Sun 9/76:30 amSFO - DSM

1 stop7h 43mUnited Airlines

Deal found 4/25

$461

Sun 7/132:00 pmDSM - SFO

1 stop10h 06mAlaska Airlines

Fri 7/189:45 amSFO - DSM

1 stop10h 21mAlaska Airlines

Deal found 4/25

$623

Best flights from Des Moines to San Francisco
Discover carefully curated flight deals from Des Moines to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 25, 2025.

Mon 5/57:20 pmDSM - SFO

1 stop21h 24mFrontier

Wed 5/76:35 amSFO - DSM

1 stop9h 55mFrontier

Deal found 4/24

$190

Wed 8/132:53 pmDSM - SFO

1 stop7h 38mDelta

Tue 8/1912:40 amSFO - DSM

1 stop7h 26mDelta

Deal found 4/25

$313

Tue 5/275:27 pmDSM - SFO

1 stop8h 55mAmerican Airlines

Sat 5/3111:49 pmSFO - DSM

1 stop9h 24mAmerican Airlines

Deal found 4/25

$332

Wed 8/136:30 amDSM - SFO

1 stop5h 35mSouthwest

Wed 8/209:55 amSFO - DSM

2 stops9h 30mSouthwest

Deal found 4/24

$356

Sun 6/810:27 pmDSM - SFO

1 stop24h 54mMultiple Airlines

Sun 6/1510:33 amSFO - DSM

2 stops34h 01mMultiple Airlines

Deal found 4/24

$372

Fri 9/58:00 amDSM - SFO

2 stops13h 05mUnited Airlines

Sun 9/76:30 amSFO - DSM

1 stop7h 43mUnited Airlines

Deal found 4/25

$461

Sun 7/132:00 pmDSM - SFO

1 stop10h 06mAlaska Airlines

Fri 7/189:45 amSFO - DSM

1 stop10h 21mAlaska Airlines

Deal found 4/25

$623

Last-minute flights from Des Moines to San Francisco
Discover last-minute flight deals from Des Moines to San Francisco. Data last updated April 25, 2025 and is based on user searches.

Wed 4/307:27 pmDSM - SFO

1 stop7h 06mMultiple Airlines

Sat 5/31:46 pmSFO - DSM

1 stop8h 07mMultiple Airlines

Deal found 4/24

$483

Wed 4/3011:38 amDSM - SFO

2 stops13h 22mUnited Airlines

Sat 5/36:30 amSFO - DSM

1 stop12h 04mUnited Airlines

Deal found 4/24

$678

Wed 4/306:30 amDSM - SFO

1 stop10h 19mDelta

Fri 5/212:47 amSFO - DSM

1 stop8h 32mDelta

Deal found 4/24

$687

Fri 5/22:37 pmDSM - SFO

2 stops8h 37mAmerican Airlines

Mon 5/53:50 pmSFO - DSM

1 stop5h 50mAmerican Airlines

Deal found 4/24

$873

Mon 5/57:20 pmDSM - SFO

1 stop21h 24mFrontier

Wed 5/76:35 amSFO - DSM

1 stop9h 55mFrontier

Deal found 4/24

$190

Mon 5/53:40 pmDSM - SFO

1 stop6h 00mSouthwest

Wed 5/77:25 amSFO - DSM

2 stops10h 30mSouthwest

Deal found 4/24

$692

Fri 5/91:31 pmDSM - SFO

2 stops29h 42mMultiple Airlines

Sun 5/116:03 pmSFO - DSM

2 stops27h 10mMultiple Airlines

Deal found 4/25

$453

Tue 5/275:27 pmDSM - SFO

1 stop8h 55mAmerican Airlines

Sat 5/3111:49 pmSFO - DSM

1 stop9h 24mAmerican Airlines

Deal found 4/25

$332

Tue 5/271:07 pmDSM - SFO

1 stop8h 37mDelta

Fri 5/3012:40 amSFO - DSM

1 stop7h 39mDelta

Deal found 4/24

$335

Tue 5/278:00 amDSM - SFO

2 stops14h 09mUnited Airlines

Sat 5/316:30 amSFO - DSM

1 stop7h 48mUnited Airlines

Deal found 4/24

$471

Sat 5/314:25 pmDSM - SFO

1 stop8h 05mSouthwest

Sat 6/711:55 amSFO - DSM

2 stops8h 40mSouthwest

Deal found 4/24

$374

One-way flights from Des Moines to San Francisco
Search for one-way flight options from Des Moines to San Francisco. Find affordable one-way fares based on user searches. Data last updated April 25, 2025.

Fri 5/27:20 pmDSM - SFO

1 stop21h 57mFrontier

Deal found 4/25

$117

Mon 6/95:00 amDSM - SFO

1 stop8h 28mAmerican Airlines

Deal found 4/24

$176

Mon 8/46:02 amDSM - SFO

1 stop8h 05mUnited Airlines

Deal found 4/24

$193

Sun 6/16:20 pmDSM - SFO

1 stop7h 30mSouthwest

Deal found 4/24

$214

Fri 5/164:43 pmDSM - SFO

2 stops26h 30mMultiple Airlines

Deal found 4/24

$225

Sun 6/85:23 pmDSM - SFO

1 stop6h 02mDelta

Deal found 4/24

$629

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Mon 5/5

7:20 pm-2:44 pm

1 stop21h 24m

San Francisco

Wed 5/7

6:35 am-6:30 pm

1 stop9h 55m

$190

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Wed 8/13

2:53 pm-8:31 pm

1 stop7h 38m

San Francisco

Tue 8/19

12:40 am-10:06 am

1 stop7h 26m

$313

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Tue 5/27

5:27 pm-12:22 am

1 stop8h 55m

San Francisco

Sat 5/31

11:49 pm-11:13 am

1 stop9h 24m

$332

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Wed 8/13

6:30 am-10:05 am

1 stop5h 35m

San Francisco

Wed 8/20

9:55 am-9:25 pm

2 stops9h 30m

$356

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Sun 6/8

10:27 pm-9:21 pm

1 stop24h 54m

San Francisco

Sun 6/15

10:33 am-10:34 pm

2 stops34h 01m

$372

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Fri 9/5

8:00 am-7:05 pm

2 stops13h 05m

San Francisco

Sun 9/7

6:30 am-4:13 pm

1 stop7h 43m

$461

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Sun 7/13

2:00 pm-10:06 pm

1 stop10h 06m

San Francisco

Fri 7/18

9:45 am-10:06 pm

1 stop10h 21m

$623

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Fri 5/2

7:20 pm-3:17 pm

1 stop21h 57m

$117

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Mon 6/9

5:00 am-11:28 am

1 stop8h 28m

$176

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Mon 8/4

6:02 am-12:07 pm

1 stop8h 05m

$193

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/25

Showing 1-10 of 13 results

Compare providers for flights from Des Moines to San Francisco

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Francisco in April.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy1 star	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*2 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars
Cheapfaremart	Price Accuracy-	Trust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Des Moines-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Francisco flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Des Moines-San Francisco flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to San Francisco

How far ahead should I book a flight from Des Moines to San Francisco?

Booking 16 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to San Francisco. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Des Moines to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Des Moines to San Francisco (average of $276). Flying from Des Moines to San Francisco in June is currently the most expensive (average of $393). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to SFO?

A simple way to save on the total cost of your ticket is to fly from Des Moines to San Francisco in the evening. If you’re flexible enough to do this you can expect to save up to 26% on your trip compared to booking a flight in the morning.

What is the cheapest day to fly from Des Moines to San Francisco?

Travelers seeking maximum savings on their Des Moines to San Francisco flight should consider departing on Wednesday afternoons when fares are most often at their lowest. Friday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Rainfall in San Francisco by month

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

Temperature in San Francisco by month

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

Reviews of airlines servicing San Francisco

Read reviews from past customers who have flown Alaska Airlines, Southwest and Delta from Des Moines to San Francisco. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Alaska Airlines

8.0

Very good

9,928 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

Alaska Airlines

8.0

Very good

9,928 reviews

Alaska Airlines

8.0

Very good

9,928 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

Southwest

8.0

Very good

4,287 reviews

Alaska Airlines

8.0

Very good

9,928 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

Delta

8.0

Very good

7,920 reviews

Alaska Airlines

8.0

Very good

9,928 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

United Airlines

7.4

Good

8,685 reviews

Alaska Airlines

8.0

Very good

9,928 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

American Airlines

7.2

Good

10,000 reviews

Alaska Airlines

8.0

Very good

9,928 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

Related info for your journey

What are the cheapest airlines flying from Des Moines to San Francisco round-trip?
Our cheapest airline available from Des Moines to San Francisco is Frontier. Our recent data shows that you can find tickets from as low as $190 on this airline. Additional options worth looking into are Delta and American Airlines, starting at $313 and $332 round-trip. Frontier is currently priced 57% below the average price you’ll pay for this route.
What are the cheapest airlines to fly from Des Moines to San Francisco one-way?
The cheapest airline one-way is Frontier, with whom users have recently found tickets for as low as $117. However, be on the lookout for offers from American Airlines and United Airlines, as they are both options that can get you from Des Moines to San Francisco for a low price.
Can I find deals for flights from Des Moines to San Francisco that include hotel bookings?
Yes. In addition to deals on Des Moines to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to San Francisco.
Can I find deals for business class flights from Des Moines to San Francisco?
Yes. Cheapflights offers flight deals from Des Moines to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to San Francisco?
Currently, January is the cheapest month in which you can book a flight from Des Moines to San Francisco (average of $276). Flying from Des Moines to San Francisco in June is currently the most expensive (average of $393). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Roseville

Mountain View

Santa Cruz

Turlock

Livermore

South San Francisco

Fairfield

Manteca

Richmond

Watsonville

Hollister

Milpitas

Antioch

Sausalito

Vallejo

Newark

Hayward

Alameda

Sunnyvale

Campbell

Browse thousands of different options on Cheapflights for your next trip

Top 5 airlines flying from Des Moines to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
Frontier	Cheapest$112	Average$218	FlexibilityNo cancel fee	On-time62%
Delta	Cheapest$285	Average$473	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$287	Average$432	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$313	Average$495	FlexibilityNo cancel fee	On-time69%
Southwest	Cheapest$356	Average$435	FlexibilityNo cancel fee	On-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

$117+ Cheap flights from Des Moines to San Francisco (DSM - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/2. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to San Francisco with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Des Moines to San Francisco are usually found in September or August, booked 16 days in advance, depart on a Wednesday or Friday and return on a Wednesday

Cheap flight deals from Des Moines to San Francisco

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Des Moines to San Francisco

Cheapest flights from Des Moines to San FranciscoExplore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 25, 2025.

Explore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 25, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to San Francisco that are best for you.

Compare providers for flights from Des Moines to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Francisco in April.

Best time to book a flight from Des Moines to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to San Francisco

How far ahead should I book a flight from Des Moines to San Francisco?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to San Francisco. Price data was last updated on April 18, 2025.

What is the cheapest month to book a flight from Des Moines to San Francisco?

What is the cheapest time of day to fly from DSM to SFO?

Find hourly flight availability from Des Moines to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 25, 2025.

What is the cheapest day to fly from Des Moines to San Francisco?

Use this chart to determine the cheapest time to fly round-trip from Des Moines to San Francisco. Price data was last updated on December 16, 2024.

Rainfall in San Francisco by month

Plan your trip to San Francisco by taking into account the average rainfall totals by month.

Temperature in San Francisco by month

Plan your trip to San Francisco by taking into account the average temperature totals by month.

Reviews of airlines servicing San Francisco

Read reviews from past customers who have flown Alaska Airlines, Southwest and Delta from Des Moines to San Francisco. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Des Moines to San Francisco round-trip?

What are the cheapest airlines to fly from Des Moines to San Francisco one-way?

Can I find deals for flights from Des Moines to San Francisco that include hotel bookings?

How can I find direct flights from Des Moines to San Francisco?

Can I find deals for business class flights from Des Moines to San Francisco?

What is the cheapest month to book a flight from Des Moines to San Francisco?

Traveling to a place near Des Moines?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.

Top 5 airlines flying from Des Moines to San Francisco

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Des Moines to San Francisco
Explore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 25, 2025.