$249+ Cheap flights from Myrtle Beach to Des Moines (MYR - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/21. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — DSM
Oct 7 — Oct 141
Round-trip
1 adult, Economy
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Find cheap flights from Myrtle Beach to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Myrtle Beach to Des Moines
Cheapest
Best
Last-minute
One-way
Cheapest flights from Myrtle Beach to Des MoinesExplore the most affordable flight options available from Myrtle Beach to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 7, 2026.
Explore the most affordable flight options available from Myrtle Beach to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 7, 2026.
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/308:08 am -
1 stop4h 56m
Mon 10/511:22 am -
1 stop7h 05m
Deal found 9/3![American Airlines logo]()
$297
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:08 am -
1 stop4h 56m
Sun 10/46:00 am -
1 stop7h 37m
Deal found 9/2![American Airlines logo]()
$397
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/235:01 pm -
1 stop7h 11m
Mon 9/281:30 pm -
1 stop6h 38m
Deal found 9/5![American Airlines logo]()
$439
This Southwest deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2311:00 am -
2 stops12h 00m
Mon 9/285:40 am -
2 stops6h 30m
Deal found 9/5![Southwest logo]()
$449
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/112:30 pm -
2 stops12h 18m
Sun 10/48:00 am -
1 stop6h 10m
Deal found 9/3![United Airlines logo]()
$456
Best flights from Myrtle Beach to Des MoinesDiscover carefully curated flight deals from Myrtle Beach to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 7, 2026.
Discover carefully curated flight deals from Myrtle Beach to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 7, 2026.
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:08 am -
1 stop4h 56m
Mon 10/52:01 pm -
2 stops7h 01m
Deal found 9/2![American Airlines logo]()
$356
This Southwest deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2311:00 am -
2 stops12h 00m
Mon 9/285:40 am -
2 stops6h 30m
Deal found 9/5![Southwest logo]()
$449
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/112:30 pm -
2 stops12h 18m
Sun 10/48:00 am -
1 stop6h 10m
Deal found 9/2![United Airlines logo]()
$456
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:30 am -
1 stop6h 34m
Mon 10/511:22 am -
1 stop7h 05m
Deal found 9/6![American Airlines logo]()
$381
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:08 am -
1 stop4h 56m
Sun 10/46:00 am -
1 stop7h 37m
Deal found 9/3![American Airlines logo]()
$397
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/235:01 pm -
1 stop7h 11m
Mon 9/281:30 pm -
1 stop6h 38m
Deal found 9/5![American Airlines logo]()
$439
Last-minute flights from Myrtle Beach to Des MoinesDiscover last-minute flight deals from Myrtle Beach to Des Moines. Data last updated September 7, 2026 and is based on user searches.
Discover last-minute flight deals from Myrtle Beach to Des Moines. Data last updated September 7, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/235:01 pm -
1 stop7h 11m
Mon 9/281:30 pm -
1 stop6h 38m
Deal found 9/5![American Airlines logo]()
$439
This Southwest deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2311:00 am -
2 stops12h 00m
Mon 9/285:40 am -
2 stops6h 30m
Deal found 9/5![Southwest logo]()
$449
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/308:08 am -
1 stop4h 56m
Mon 10/511:22 am -
1 stop7h 05m
Deal found 9/3![American Airlines logo]()
$297
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:08 am -
1 stop4h 56m
Sun 10/46:00 am -
1 stop7h 37m
Deal found 9/2![American Airlines logo]()
$397
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/112:30 pm -
2 stops12h 18m
Sun 10/48:00 am -
1 stop6h 10m
Deal found 9/2![United Airlines logo]()
$456
One-way flights from Myrtle Beach to Des MoinesSearch for one-way flight options from Myrtle Beach to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 7, 2026.
Search for one-way flight options from Myrtle Beach to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 7, 2026.
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/217:19 pm -
1 stop5h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![American Airlines logo]()
$249
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/211:55 pm -
2 stops9h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Southwest logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/212:41 pm -
3 stops48h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Multiple Airlines logo]()
$617
Find flight deals from Myrtle Beach to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 7, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $297 (American Airlines) |
One-way from | $249 (American Airlines) |
Popular in | July |
Cheapest in | February |
Average price | $406 |
Cheapflights Fare Finder
Customize your flight search to find flights from Myrtle Beach to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 7, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Myrtle BeachDes Moines
MYR Myrtle Beach Intl - DSM Des Moines
MYRDSM
Myrtle Beach Intl
Mon 9/21
1:55 pm-10:15 pm
2 stops9h 20m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$254
Myrtle BeachDes Moines
MYR Myrtle Beach Intl - DSM Des Moines
MYRDSM
Myrtle Beach Intl
Thu 10/1
8:08 am-12:04 pm
1 stop4h 56m
Des Moines
Mon 10/5
2:01 pm-10:02 pm
2 stops7h 01m
$356
Myrtle BeachDes Moines
MYR Myrtle Beach Intl - DSM Des Moines
MYRDSM
Myrtle Beach Intl
Wed 9/30
6:30 am-12:04 pm
1 stop6h 34m
Des Moines
Mon 10/5
11:22 am-7:27 pm
1 stop7h 05m
$381
Myrtle BeachDes Moines
MYR Myrtle Beach Intl - DSM Des Moines
MYRDSM
Myrtle Beach Intl
Thu 10/1
8:08 am-12:04 pm
1 stop4h 56m
Des Moines
Sun 10/4
6:00 am-2:37 pm
1 stop7h 37m
$397
Myrtle BeachDes Moines
MYR Myrtle Beach Intl - DSM Des Moines
MYRDSM
Myrtle Beach Intl
Wed 9/23
5:01 pm-11:12 pm
1 stop7h 11m
Des Moines
Mon 9/28
1:30 pm-9:08 pm
1 stop6h 38m
$439
Myrtle BeachDes Moines
MYR Myrtle Beach Intl - DSM Des Moines
MYRDSM
Myrtle Beach Intl
Wed 9/23
11:00 am-10:00 pm
2 stops12h 00m
Des Moines
Mon 9/28
5:40 am-1:10 pm
2 stops6h 30m
$449
Myrtle BeachDes Moines
MYR Myrtle Beach Intl - DSM Des Moines
MYRDSM
Myrtle Beach Intl
Thu 10/1
12:30 pm-11:48 pm
2 stops12h 18m
Des Moines
Sun 10/4
8:00 am-3:10 pm
1 stop6h 10m
$456
Myrtle BeachDes Moines
MYR Myrtle Beach Intl - DSM Des Moines
MYRDSM
Myrtle Beach Intl
Mon 9/21
2:41 pm-2:31 pm
3 stops48h 50m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$617
Sorted by cheapest first
Compare providers for flights from Myrtle Beach to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Des Moines in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Myrtle Beach-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Myrtle Beach-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Myrtle Beach to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Myrtle Beach with our price prediction graph.
MYR-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Myrtle Beach to Des Moines
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated September 7, 2026.
Read through reviews of airlines operating flights from Myrtle Beach to Des Moines, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.2
Crew
7.9
Food
6.4
Overall
7.1
Entertainment
6.8
Boarding
7.5
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Comfort
7.2
Crew
7.9
Food
6.4
Overall
7.1
Entertainment
6.8
Boarding
7.5
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from Myrtle Beach to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
Ames
Johnston
Boone
Norwalk
West Des Moines
Ankeny
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Complete your trip
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Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 7, 2026.
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Myrtle Beach and Des Moines flights
Browse other Myrtle Beach and Des Moines flight options. Last updated on September 7, 2026.
Other flights from Myrtle Beach
Browse through other flights departing from Myrtle Beach. Flights are based on user searches made on Cheapflights and were last updated on September 7, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Myrtle Beach to Des Moines
Discover the top airline that operate flights from Myrtle Beach to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 7, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$312 | Average$376 | FlexibilityNo cancel fee | On-time71% |