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Des Moines

$317+ Cheap flights from Myrtle Beach to Des Moines (MYR - DSM)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/1. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — DSM
Aug 22 — Aug 291
Sat 8/22
Sat 8/29
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Des Moines

Cheapest flights from Myrtle Beach to Des Moines
Explore the most affordable flight options available from Myrtle Beach to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 23, 2026.

This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/11:56 pm
MYR
-
DSM
1 stop6h 52m
American Airlines
Mon 10/56:00 am
DSM
-
MYR
1 stop4h 40m
American Airlines
Deal found 7/22$317
This Southwest deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:40 am
MYR
-
DSM
1 stop5h 30m
Southwest
Tue 10/65:35 am
DSM
-
MYR
2 stops6h 55m
Southwest
Deal found 7/23$322
This American Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:30 am
MYR
-
DSM
1 stop6h 34m
American Airlines
Mon 10/511:22 am
DSM
-
MYR
1 stop7h 05m
American Airlines
Deal found 7/19$337
This Southwest deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/272:10 pm
MYR
-
DSM
2 stops8h 45m
Southwest
Sat 10/315:50 am
DSM
-
MYR
1 stop4h 10m
Southwest
Deal found 7/19$342
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/11:56 pm
MYR
-
DSM
1 stop6h 52m
American Airlines
Sun 10/411:00 am
DSM
-
MYR
1 stop5h 25m
American Airlines
Deal found 7/22$362
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/182:30 pm
MYR
-
DSM
2 stops8h 40m
Southwest
Mon 9/215:40 am
DSM
-
MYR
2 stops6h 30m
Southwest
Deal found 7/20$382
This American Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:04 pm
MYR
-
DSM
1 stop6h 40m
American Airlines
Tue 8/111:08 pm
DSM
-
MYR
1 stop6h 51m
American Airlines
Deal found 7/21$402

Find flight deals from Myrtle Beach to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 23, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$317
(American Airlines)
Provider with most accurate pricing for Myrtle Beach Intl-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Des Moines flights.
Search Deals
From Myrtle Beach Intl to Des Moines
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 23, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 10/1

6:40 am-11:10 am

1 stop5h 30m

Des Moines

Tue 10/6

5:35 am-1:30 pm

2 stops6h 55m

$322

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Tue 10/27

6:58 pm-10:34 pm

1 stop4h 36m

Des Moines

Sat 10/31

4:01 pm-9:43 pm

1 stop4h 42m

$337
Quickest round-trip

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Tue 10/27

7:50 am-11:30 am

1 stop4h 40m

Des Moines

Sat 10/31

5:50 am-11:00 am

1 stop4h 10m

$337

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 10/1

5:01 pm-11:12 pm

1 stop7h 11m

Des Moines

Sun 10/4

6:00 am-2:37 pm

1 stop7h 37m

$362

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Fri 9/18

8:10 am-11:25 am

1 stop4h 15m

Des Moines

Mon 9/21

5:40 am-1:10 pm

2 stops6h 30m

$377

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 8/6

10:34 am-9:22 pm

2 stops11h 48m

Des Moines

Tue 8/11

6:00 am-2:53 pm

1 stop7h 53m

$421

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Sat 8/8

6:23 pm-9:31 pm

1 stop28h 08m

Des Moines

Sat 8/15

1:18 pm-3:19 pm

2 stops25h 01m

$429

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 10/1

12:10 pm-7:21 pm

2 stops8h 11m

Des Moines

Mon 10/5

2:01 pm-11:58 pm

2 stops8h 57m

$457
Cheapest one-way
Quickest one-way

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 7/29

6:10 pm-12:09 am

1 stop6h 59m

$334

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Sun 8/2

11:52 am-9:11 pm

2 stops34h 19m

$431

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/20

Showing 1-10 of 11 resultsSorted by cheapest first
1
2

Compare providers for flights from Myrtle Beach to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Des Moines in July.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated July 23, 2026.
Read through reviews of airlines operating flights from Myrtle Beach to Des Moines, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,832 reviews

Crew

7.9

Food

6.4

Overall

7.1

Boarding

7.5

Comfort

7.2

Entertainment

6.8

Reviews

1 / 20
10.0
Excellent

Linda,Jul 2026

ROA - CLT

Very helpful and friendly people who pushed me where I needed to go
American Airlines
7.1
Good
11,832 reviews
American Airlines
7.1
Good
11,832 reviews

Crew

7.9

Food

6.4

Overall

7.1

Boarding

7.5

Comfort

7.2

Entertainment

6.8

Reviews

1 / 20
10.0
Excellent

Linda,Jul 2026

ROA - CLT

Very helpful and friendly people who pushed me where I needed to go

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Des Moines?

    For as low as $337, American Airlines can have you in Des Moines from Myrtle Beach in 4h 36m. The distance between Myrtle Beach and Des Moines is about 969 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Myrtle Beach to Des Moines round-trip?

    American Airlines, at $238, was found to be the cheapest airline from Myrtle Beach to Des Moines..

  • Can I find deals for flights from Myrtle Beach to Des Moines that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Des Moines.

  • Can I find deals for business class flights from Myrtle Beach to Des Moines?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Ames
Clive
Johnston
Boone
West Des Moines
Ankeny

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Top airline flying from Myrtle Beach to Des Moines

Discover the top airline that operate flights from Myrtle Beach to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 23, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$238Average$376FlexibilityNo cancel feeOn-time71%

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