$320+ Cheap flights from Myrtle Beach to Des Moines (MYR - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/12. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — DSM
Nov 25 — Dec 21
Round-trip
1 adult, Economy
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Find cheap flights from Myrtle Beach to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Myrtle Beach to Des Moines
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Best
Last-minute
Cheapest flights from Myrtle Beach to Des MoinesExplore the most affordable flight options available from Myrtle Beach to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 26, 2026.
Explore the most affordable flight options available from Myrtle Beach to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 26, 2026.
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:10 am -
1 stop6h 38m
Tue 11/1011:09 am -
1 stop4h 14m
Deal found 10/22![American Airlines logo]()
$409
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/61:40 pm -
2 stops10h 25m
Tue 11/106:00 am -
2 stops11h 25m
Deal found 10/22![Southwest logo]()
$425
This Southwest deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1710:45 am -
2 stops12h 20m
Mon 12/285:10 am -
2 stops12h 30m
Deal found 10/25![Southwest logo]()
$611
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/176:59 pm -
1 stop4h 39m
Mon 12/283:45 pm -
1 stop6h 17m
Deal found 10/25![Delta logo]()
$638
This Southwest deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/217:10 pm -
1 stop4h 50m
Sat 11/286:45 am -
2 stops11h 20m
Deal found 10/24![Southwest logo]()
$642
This Delta deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:51 pm -
1 stop4h 44m
Sat 11/285:30 am -
1 stop7h 03m
Deal found 10/24![Delta logo]()
$659
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/611:27 am -
3 stops12h 32m
Tue 11/106:05 am -
2 stops10h 06m
Deal found 10/22![United Airlines logo]()
$684
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/175:30 am -
2 stops10h 26m
Mon 12/286:16 pm -
1 stop13h 19m
Deal found 10/25![American Airlines logo]()
$711
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2811:27 am -
2 stops11h 28m
Fri 10/306:45 pm -
2 stops21h 26m
Deal found 10/20![United Airlines logo]()
$992
Best flights from Myrtle Beach to Des MoinesDiscover carefully curated flight deals from Myrtle Beach to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 26, 2026.
Discover carefully curated flight deals from Myrtle Beach to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 26, 2026.
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/126:12 am -
1 stop5h 05m
Fri 1/158:07 am -
1 stop5h 55m
Deal found 10/22![American Airlines logo]()
$320
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/61:40 pm -
2 stops10h 25m
Tue 11/106:00 am -
2 stops11h 25m
Deal found 10/22![Southwest logo]()
$425
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/176:59 pm -
1 stop4h 39m
Mon 12/283:45 pm -
1 stop6h 17m
Deal found 10/25![Delta logo]()
$638
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/611:27 am -
3 stops12h 32m
Tue 11/106:05 am -
2 stops10h 06m
Deal found 10/22![United Airlines logo]()
$684
This Southwest deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1710:45 am -
2 stops12h 20m
Mon 12/285:10 am -
2 stops12h 30m
Deal found 10/25![Southwest logo]()
$611
This Delta deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:51 pm -
1 stop4h 44m
Sat 11/285:30 am -
1 stop7h 03m
Deal found 10/24![Delta logo]()
$659
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/126:29 pm -
3 stops26h 53m
Fri 1/151:42 pm -
2 stops27h 06m
Deal found 10/22![United Airlines logo]()
$702
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/175:30 am -
2 stops10h 26m
Mon 12/286:16 pm -
1 stop13h 19m
Deal found 10/25![American Airlines logo]()
$711
This Southwest deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2110:10 am -
2 stops12h 40m
Sat 11/286:45 am -
2 stops11h 20m
Deal found 10/24![Southwest logo]()
$802
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/511:27 am -
2 stops11h 28m
Mon 11/98:00 am -
3 stops25h 21m
Deal found 10/25![United Airlines logo]()
$963
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1712:01 pm -
3 stops10h 22m
Mon 12/285:00 am -
2 stops9h 21m
Deal found 10/25![United Airlines logo]()
$1,427
Last-minute flights from Myrtle Beach to Des MoinesDiscover last-minute flight deals from Myrtle Beach to Des Moines. Data last updated October 26, 2026 and is based on user searches.
Discover last-minute flight deals from Myrtle Beach to Des Moines. Data last updated October 26, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2811:27 am -
2 stops11h 28m
Fri 10/306:45 pm -
2 stops21h 26m
Deal found 10/20![United Airlines logo]()
$992
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:10 am -
1 stop6h 38m
Tue 11/1011:09 am -
1 stop4h 14m
Deal found 10/22![American Airlines logo]()
$409
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/61:40 pm -
2 stops10h 25m
Tue 11/106:00 am -
2 stops11h 25m
Deal found 10/22![Southwest logo]()
$425
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/611:27 am -
3 stops12h 32m
Tue 11/106:05 am -
2 stops10h 06m
Deal found 10/22![United Airlines logo]()
$684
This Southwest deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/217:10 pm -
1 stop4h 50m
Sat 11/286:45 am -
2 stops11h 20m
Deal found 10/24![Southwest logo]()
$642
This Delta deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:51 pm -
1 stop4h 44m
Sat 11/285:30 am -
1 stop7h 03m
Deal found 10/24![Delta logo]()
$659
Find flight deals from Myrtle Beach to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 26, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $320 (American Airlines) |
Popular in | July |
Cheapest in | February |
Average price | $326 |
Cheapflights Fare Finder
Customize your flight search to find flights from Myrtle Beach to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 26, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Myrtle BeachDes Moines
MYR Myrtle Beach Intl - DSM Des Moines
MYRDSM
Myrtle Beach Intl
Tue 1/12
6:12 am-10:17 am
1 stop5h 05m
Des Moines
Fri 1/15
8:07 am-3:02 pm
1 stop5h 55m
$320
Myrtle BeachDes Moines
MYR Myrtle Beach Intl - DSM Des Moines
MYRDSM
Myrtle Beach Intl
Fri 11/6
1:40 pm-11:05 pm
2 stops10h 25m
Des Moines
Tue 11/10
6:00 am-6:25 pm
2 stops11h 25m
$425
Myrtle BeachDes Moines
MYR Myrtle Beach Intl - DSM Des Moines
MYRDSM
Myrtle Beach Intl
Thu 12/17
10:45 am-10:05 pm
2 stops12h 20m
Des Moines
Mon 12/28
5:10 am-6:40 pm
2 stops12h 30m
$611
Quickest round-trip
Myrtle BeachDes Moines
MYR Myrtle Beach Intl - DSM Des Moines
MYRDSM
Myrtle Beach Intl
Thu 12/17
6:59 pm-10:38 pm
1 stop4h 39m
Des Moines
Mon 12/28
3:45 pm-11:02 pm
1 stop6h 17m
$638
Myrtle BeachDes Moines
MYR Myrtle Beach Intl - DSM Des Moines
MYRDSM
Myrtle Beach Intl
Sat 11/21
6:51 pm-10:35 pm
1 stop4h 44m
Des Moines
Sat 11/28
5:30 am-1:33 pm
1 stop7h 03m
$659
Myrtle BeachDes Moines
MYR Myrtle Beach Intl - DSM Des Moines
MYRDSM
Myrtle Beach Intl
Fri 11/6
11:27 am-10:59 pm
3 stops12h 32m
Des Moines
Tue 11/10
6:05 am-5:11 pm
2 stops10h 06m
$684
Myrtle BeachDes Moines
MYR Myrtle Beach Intl - DSM Des Moines
MYRDSM
Myrtle Beach Intl
Tue 1/12
6:29 pm-8:22 pm
3 stops26h 53m
Des Moines
Fri 1/15
1:42 pm-5:48 pm
2 stops27h 06m
$702
Myrtle BeachDes Moines
MYR Myrtle Beach Intl - DSM Des Moines
MYRDSM
Myrtle Beach Intl
Thu 12/17
5:30 am-2:56 pm
2 stops10h 26m
Des Moines
Mon 12/28
6:16 pm-8:35 am
1 stop13h 19m
$711
Myrtle BeachDes Moines
MYR Myrtle Beach Intl - DSM Des Moines
MYRDSM
Myrtle Beach Intl
Sat 11/21
10:10 am-9:50 pm
2 stops12h 40m
Des Moines
Sat 11/28
6:45 am-7:05 pm
2 stops11h 20m
$802
Myrtle BeachDes Moines
MYR Myrtle Beach Intl - DSM Des Moines
MYRDSM
Myrtle Beach Intl
Thu 11/5
11:27 am-9:55 pm
2 stops11h 28m
Des Moines
Mon 11/9
8:00 am-10:21 am
3 stops25h 21m
$963
Showing 1-10 of 11 resultsSorted by cheapest first
Compare providers for flights from Myrtle Beach to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Des Moines in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Myrtle Beach-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Myrtle Beach-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Myrtle Beach to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Myrtle Beach with our price prediction graph.
MYR-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated October 26, 2026.
Read through reviews of airlines operating flights from Myrtle Beach to Des Moines, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.0
Boarding
7.4
Food
6.4
Entertainment
6.8
Crew
7.9
Comfort
7.1
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Overall
7.0
Boarding
7.4
Food
6.4
Entertainment
6.8
Crew
7.9
Comfort
7.1
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from Myrtle Beach to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
West Des Moines
Ames
Johnston
Boone
Norwalk
Ankeny
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Complete your trip
Complete your trip to Des Moines by adding a car rental and/or hotel reservation to your travel itinerary.
Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 26, 2026.
Search flights from Myrtle Beach to Des Moines by cabin class
Find flights from Myrtle Beach to Des Moines, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Myrtle Beach and Des Moines flights
Browse other Myrtle Beach and Des Moines flight options. Last updated on October 26, 2026.
Other flights from Myrtle Beach
Browse through other flights departing from Myrtle Beach. Flights are based on user searches made on Cheapflights and were last updated on October 26, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Myrtle Beach to Des Moines
Discover the top airline that operate flights from Myrtle Beach to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$312 | Average$376 | FlexibilityNo cancel fee | On-time71% |