$171+ Cheap flights from Myrtle Beach to Des Moines (MYR - DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/17. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — DSM
May 25 — Jun 11
Round-trip
1 adult, Economy
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Find cheap flights from Myrtle Beach to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Myrtle Beach to Des Moines
Cheapest
Best
Last-minute
One-way
Cheapest flights from Myrtle Beach to Des MoinesExplore the most affordable flight options available from Myrtle Beach to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 25, 2026.
Explore the most affordable flight options available from Myrtle Beach to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 25, 2026.
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/911:10 am
MYR
- DSM
1 stop6h 39m
Delta
Mon 9/216:30 pm
DSM
- MYR
1 stop4h 09m
Delta
Deal found 4/20![Delta logo]()
$290
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/94:15 pm
MYR
- DSM
2 stops7h 52m
American Airlines
Mon 9/217:05 am
DSM
- MYR
1 stop7h 27m
American Airlines
Deal found 4/20![American Airlines logo]()
$295
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/98:10 pm
MYR
- DSM
1 stop18h 40m
Multiple Airlines
Sun 7/123:59 pm
DSM
- MYR
2 stops21h 39m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$332
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:45 pm
MYR
- DSM
1 stop4h 41m
Delta
Mon 10/56:30 pm
DSM
- MYR
1 stop4h 09m
Delta
Deal found 4/20![Delta logo]()
$335
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/304:15 pm
MYR
- DSM
2 stops8h 13m
American Airlines
Mon 10/56:36 pm
DSM
- MYR
1 stop3h 51m
American Airlines
Deal found 4/20![American Airlines logo]()
$340
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/174:17 pm
MYR
- DSM
2 stops8h 53m
American Airlines
Tue 6/237:00 am
DSM
- MYR
2 stops9h 26m
American Airlines
Deal found 4/24![American Airlines logo]()
$345
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/12:46 pm
MYR
- DSM
1 stop18h 49m
Multiple Airlines
Mon 10/56:30 am
DSM
- MYR
1 stop10h 19m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$359
Best flights from Myrtle Beach to Des MoinesDiscover carefully curated flight deals from Myrtle Beach to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 25, 2026.
Discover carefully curated flight deals from Myrtle Beach to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 25, 2026.
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3011:10 am
MYR
- DSM
1 stop6h 39m
Delta
Mon 10/56:30 pm
DSM
- MYR
1 stop4h 09m
Delta
Deal found 4/22![Delta logo]()
$335
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/176:06 pm
MYR
- DSM
1 stop7h 04m
American Airlines
Tue 6/237:00 am
DSM
- MYR
2 stops9h 26m
American Airlines
Deal found 4/24![American Airlines logo]()
$340
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/13:20 pm
MYR
- DSM
1 stop6h 57m
United Airlines
Mon 10/56:15 am
DSM
- MYR
1 stop7h 18m
United Airlines
Deal found 4/20![United Airlines logo]()
$407
This Southwest deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/97:25 am
MYR
- DSM
1 stop5h 05m
Southwest
Sun 7/124:15 pm
DSM
- MYR
1 stop5h 30m
Southwest
Deal found 4/24![Southwest logo]()
$407
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/176:00 am
MYR
- DSM
1 stop5h 43m
Delta
Tue 6/236:39 pm
DSM
- MYR
1 stop4h 20m
Delta
Deal found 4/24![Delta logo]()
$335
This Southwest deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:05 am
MYR
- DSM
1 stop5h 15m
Southwest
Sun 10/45:35 am
DSM
- MYR
2 stops10h 25m
Southwest
Deal found 4/24![Southwest logo]()
$422
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/115:15 am
MYR
- DSM
1 stop8h 35m
Southwest
Sun 6/145:10 am
DSM
- MYR
2 stops7h 15m
Southwest
Deal found 4/23![Southwest logo]()
$422
Last-minute flights from Myrtle Beach to Des MoinesDiscover last-minute flight deals from Myrtle Beach to Des Moines. Data last updated April 25, 2026 and is based on user searches.
Discover last-minute flight deals from Myrtle Beach to Des Moines. Data last updated April 25, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/53:14 pm
MYR
- DSM
1 stop7h 09m
United Airlines
Sat 5/96:15 am
DSM
- MYR
1 stop7h 03m
United Airlines
Deal found 4/20![United Airlines logo]()
$487
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/511:15 am
MYR
- DSM
2 stops11h 00m
Southwest
Sat 5/95:35 am
DSM
- MYR
1 stop4h 30m
Southwest
Deal found 4/20![Southwest logo]()
$492
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/73:14 pm
MYR
- DSM
1 stop7h 09m
United Airlines
Sun 5/108:00 am
DSM
- MYR
1 stop5h 18m
United Airlines
Deal found 4/20![United Airlines logo]()
$567
This United Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/911:30 am
MYR
- DSM
2 stops12h 15m
United Airlines
Wed 5/138:15 am
DSM
- MYR
3 stops29h 03m
United Airlines
Deal found 4/24![United Airlines logo]()
$842
One-way flights from Myrtle Beach to Des MoinesSearch for one-way flight options from Myrtle Beach to Des Moines. Find affordable one-way fares based on user searches. Data last updated April 25, 2026.
Search for one-way flight options from Myrtle Beach to Des Moines. Find affordable one-way fares based on user searches. Data last updated April 25, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/178:44 pm
MYR
- DSM
2 stops27h 14m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$171
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/174:38 pm
MYR
- DSM
1 stop8h 20m
American Airlines
Deal found 4/20![American Airlines logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/59:39 pm
MYR
- DSM
3 stops41h 07m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$219
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/256:06 pm
MYR
- DSM
1 stop7h 04m
American Airlines
Deal found 4/21![American Airlines logo]()
$224
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/51:43 pm
MYR
- DSM
1 stop5h 02m
Delta
Deal found 4/20![Delta logo]()
$244
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/58:14 am
MYR
- DSM
2 stops9h 17m
American Airlines
Deal found 4/20![American Airlines logo]()
$249
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/2510:34 am
MYR
- DSM
3 stops24h 53m
United Airlines
Deal found 4/22![United Airlines logo]()
$424
Find flight deals from Myrtle Beach to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 25, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $290 (Delta) |
One-way from | $171 (Kiwi.com) |
Popular in | December |
Cheapest in | July |
Average price | $340 |
Cheapflights Fare Finder
Customize your flight search to find flights from Myrtle Beach to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 25, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Myrtle BeachDes Moines
MYR - DSM
MYRDSM
Myrtle Beach Intl
Wed 9/30
11:10 am-4:49 pm
1 stop6h 39m
Des Moines
Mon 10/5
6:30 pm-11:39 pm
1 stop4h 09m
$335
Quickest round-trip
Myrtle BeachDes Moines
MYR - DSM
MYRDSM
Myrtle Beach Intl
Wed 6/17
6:00 am-10:43 am
1 stop5h 43m
Des Moines
Tue 6/23
6:39 pm-11:59 pm
1 stop4h 20m
$335
Myrtle BeachDes Moines
MYR - DSM
MYRDSM
Myrtle Beach Intl
Wed 6/17
6:06 pm-12:10 am
1 stop7h 04m
Des Moines
Tue 6/23
7:00 am-5:26 pm
2 stops9h 26m
$340
Myrtle BeachDes Moines
MYR - DSM
MYRDSM
Myrtle Beach Intl
Thu 10/1
3:20 pm-9:17 pm
1 stop6h 57m
Des Moines
Mon 10/5
6:15 am-2:33 pm
1 stop7h 18m
$407
Myrtle BeachDes Moines
MYR - DSM
MYRDSM
Myrtle Beach Intl
Thu 7/9
7:25 am-11:30 am
1 stop5h 05m
Des Moines
Sun 7/12
4:15 pm-10:45 pm
1 stop5h 30m
$407
Myrtle BeachDes Moines
MYR - DSM
MYRDSM
Myrtle Beach Intl
Thu 10/1
7:05 am-11:20 am
1 stop5h 15m
Des Moines
Sun 10/4
5:35 am-5:00 pm
2 stops10h 25m
$422
Myrtle BeachDes Moines
MYR - DSM
MYRDSM
Myrtle Beach Intl
Thu 6/11
5:15 am-12:50 pm
1 stop8h 35m
Des Moines
Sun 6/14
5:10 am-1:25 pm
2 stops7h 15m
$422
Cheapest one-way
Myrtle BeachDes Moines
MYR - DSM
MYRDSM
Myrtle Beach Intl
Wed 6/17
4:38 pm-11:58 pm
1 stop8h 20m
$204
Myrtle BeachDes Moines
MYR - DSM
MYRDSM
Myrtle Beach Intl
Thu 6/25
4:17 pm-12:10 am
2 stops8h 53m
$229
Quickest one-way
Myrtle BeachDes Moines
MYR - DSM
MYRDSM
Myrtle Beach Intl
Tue 5/5
1:43 pm-5:45 pm
1 stop5h 02m
$244
Showing 1-10 of 11 resultsSorted by cheapest first
Compare providers for flights from Myrtle Beach to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Des Moines in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Myrtle Beach-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Myrtle Beach-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Myrtle Beach to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Myrtle Beach with our price prediction graph.
MYR-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Myrtle Beach to Des Moines
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated April 25, 2026.
Read through reviews of airlines operating flights from Myrtle Beach to Des Moines, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Entertainment
7.8
Crew
8.5
Food
7.2
Boarding
8.1
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Entertainment
7.8
Crew
8.5
Food
7.2
Boarding
8.1
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Entertainment
7.8
Crew
8.5
Food
7.2
Boarding
8.1
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Myrtle Beach to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Johnston
Ames
Clive
Boone
West Des Moines
Ankeny
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Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 25, 2026.
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Myrtle Beach and Des Moines flights
Browse other Myrtle Beach and Des Moines flight options. Last updated on April 25, 2026.
Other flights from Myrtle Beach
Browse through other flights departing from Myrtle Beach. Flights are based on user searches made on Cheapflights and were last updated on April 25, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Myrtle Beach to Des Moines
Discover the top 2 airlines that operate flights from Myrtle Beach to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 25, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$238 | Average$345 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$270 | Average$341 | FlexibilityNo cancel fee | On-timeN/A |