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Myrtle Beach

$319+ Cheap flights from Des Moines to Myrtle Beach (DSM - MYR)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/4. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MYR
Feb 14 — Feb 211
Sat 2/14
Sat 2/21
1 adult, Economy
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Cheap flight deals from Des Moines to Myrtle Beach

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Myrtle Beach (MYR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 15, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$319
(American Airlines)

Popular in

June

Cheapest in

January

Average price

$297
Provider with most accurate pricing for Des Moines-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Myrtle Beach Intl flights.
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From Des Moines to Myrtle Beach Intl
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($45 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Des Moines to Myrtle Beach

Cheapest flights from Des Moines to Myrtle Beach
Explore the most affordable flight options available from Des Moines to Myrtle Beach. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 15, 2026.

This American Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/34:25 pm
DSM
-
MYR
1 stop6h 32m
American Airlines
Tue 2/1010:18 am
MYR
-
DSM
1 stop6h 27m
American Airlines
Deal found 1/13$319
This Southwest deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/106:10 am
DSM
-
MYR
2 stops7h 15m
Southwest
Sat 2/1410:25 am
MYR
-
DSM
2 stops9h 50m
Southwest
Deal found 1/13$328
This Southwest deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/46:10 am
DSM
-
MYR
2 stops7h 15m
Southwest
Tue 3/103:40 pm
MYR
-
DSM
2 stops7h 25m
Southwest
Deal found 1/14$330
This American Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/106:00 am
DSM
-
MYR
1 stop7h 55m
American Airlines
Sat 2/149:10 am
MYR
-
DSM
2 stops10h 09m
American Airlines
Deal found 1/13$333
This American Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/76:00 am
DSM
-
MYR
1 stop7h 36m
American Airlines
Sat 2/149:10 am
MYR
-
DSM
1 stop5h 07m
American Airlines
Deal found 1/14$341
This American Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/212:03 pm
DSM
-
MYR
2 stops9h 19m
American Airlines
Tue 5/512:19 pm
MYR
-
DSM
2 stops9h 28m
American Airlines
Deal found 1/14$344
This Delta deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/712:25 pm
DSM
-
MYR
2 stops10h 16m
Delta
Sat 2/141:10 pm
MYR
-
DSM
1 stop4h 47m
Delta
Deal found 1/14$346
This United Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:15 am
DSM
-
MYR
1 stop7h 17m
United Airlines
Tue 5/123:25 pm
MYR
-
DSM
1 stop7h 11m
United Airlines
Deal found 1/15$353

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Myrtle Beach that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 15, 2026.
Use the filters below to find and compare flights from Des Moines to Myrtle Beach that are best for you.

Fly from

Des Moines

Fly to

Myrtle Beach

Route

Depart

Return

Price

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Wed 3/4

2:00 pm-8:45 pm

1 stop5h 45m

Myrtle Beach Intl

Tue 3/10

5:38 pm-11:42 pm

1 stop7h 04m

$319

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Tue 2/3

6:07 am-4:59 pm

2 stops9h 52m

Myrtle Beach Intl

Tue 2/10

7:19 pm-11:08 pm

1 stop4h 49m

$324

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Tue 2/10

6:10 am-2:25 pm

2 stops7h 15m

Myrtle Beach Intl

Sat 2/14

10:25 am-7:15 pm

2 stops9h 50m

$328

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Tue 2/10

4:25 pm-11:57 pm

1 stop6h 32m

Myrtle Beach Intl

Sat 2/14

9:10 am-1:17 pm

1 stop5h 07m

$328

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Wed 3/4

6:10 am-2:25 pm

2 stops7h 15m

Myrtle Beach Intl

Tue 3/10

3:40 pm-10:05 pm

2 stops7h 25m

$330

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Wed 2/18

6:10 am-2:25 pm

2 stops7h 15m

Myrtle Beach Intl

Wed 2/25

11:05 am-7:20 pm

2 stops9h 15m

$330

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Sat 2/7

6:00 am-2:36 pm

1 stop7h 36m

Myrtle Beach Intl

Tue 2/10

12:05 pm-3:45 pm

1 stop4h 40m

$330

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Wed 3/4

6:00 am-11:39 am

1 stop4h 39m

Myrtle Beach Intl

Mon 3/9

9:14 am-1:07 pm

1 stop4h 53m

$330

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/14

Compare providers for flights from Des Moines to Myrtle Beach

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Myrtle Beach in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Myrtle Beach flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Myrtle Beach flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Myrtle Beach flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Myrtle Beach flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Myrtle Beach flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Myrtle Beach

Have a flexible travel schedule? Discover the best time to fly to Myrtle Beach from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Myrtle Beach

How far ahead should I book a flight from Des Moines to Myrtle Beach?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Myrtle Beach. Price data was last updated on January 9, 2026.

The price you pay for your flight from Des Moines to Myrtle Beach may vary depending on when you book. For the best chance of a lower fare, look to book 40 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Des Moines to Myrtle Beach?

Currently, May is the cheapest month in which you can book a flight from Des Moines to Myrtle Beach (average of $166). Flying from Des Moines to Myrtle Beach in February is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Des Moines to Myrtle Beach?

Reviews of airlines servicing Myrtle Beach

Get insights into the airlines that provide service to Myrtle Beach. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Myrtle Beach. Reviews last updated January 15, 2026.
See what other customers who have flown with Southwest, Delta, and United Airlines from Des Moines to Myrtle Beach have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,258 reviews

Comfort

8.0

Overall

8.0

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,258 reviews
Southwest
8.0
Very good
4,258 reviews

Comfort

8.0

Overall

8.0

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Delta
7.9
Good
8,051 reviews
Southwest
8.0
Very good
4,258 reviews

Comfort

8.0

Overall

8.0

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
United Airlines
7.4
Good
9,164 reviews
Southwest
8.0
Very good
4,258 reviews

Comfort

8.0

Overall

8.0

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,136 reviews
Southwest
8.0
Very good
4,258 reviews

Comfort

8.0

Overall

8.0

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Myrtle Beach. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Myrtle Beach?

    There are many flights that can get you from Des Moines to Myrtle Beach in 5h 45m. Fly via American Airlines or Southwest to get the fastest option. Des Moines and Myrtle Beach are separated by a distance of 969 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Des Moines to Myrtle Beach round-trip?

    Our cheapest airline available from Des Moines to Myrtle Beach is American Airlines. Our recent data shows that you can find tickets from as low as $248 on this airline. Additional options worth looking into are Southwest and Delta, starting at $272 and $292 round-trip. American Airlines is currently priced 34% below the average price you’ll pay for this route.

  • Can I find deals for flights from Des Moines to Myrtle Beach that include hotel bookings?

    Yes. In addition to deals on Des Moines to Myrtle Beach flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Myrtle Beach?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Myrtle Beach.

  • Can I find deals for business class flights from Des Moines to Myrtle Beach?

    Yes. Cheapflights offers flight deals from Des Moines to Myrtle Beach by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Myrtle Beach?

    Currently, May is the cheapest month in which you can book a flight from Des Moines to Myrtle Beach (average of $166). Flying from Des Moines to Myrtle Beach in February is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Myrtle Beach?

Book flights to Myrtle Beach if you plan to visit one of these locations
Conway
Surfside Beach
Little River
Pawleys Island
Ocean Isle Beach
Garden City Beach

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Top 4 airlines flying from Des Moines to Myrtle Beach

Discover the top 4 airlines that operate flights from Des Moines to Myrtle Beach. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 15, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$367FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$272Average$387FlexibilityNo cancel feeOn-time63%
DeltaCheapest$292Average$376FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$366Average$436FlexibilityNo cancel feeOn-time69%

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