$297+ Cheap flights from Des Moines to Myrtle Beach (DSM - MYR)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/7. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MYR
Oct 8 — Oct 151
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Myrtle Beach with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Myrtle Beach
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One-way
Cheapest flights from Des Moines to Myrtle BeachExplore the most affordable flight options available from Des Moines to Myrtle Beach. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 8, 2026.
Explore the most affordable flight options available from Des Moines to Myrtle Beach. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 8, 2026.
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/711:09 am -
1 stop4h 14m
Thu 11/125:10 am -
1 stop6h 38m
Deal found 9/3![American Airlines logo]()
$297
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/75:20 am -
2 stops13h 10m
Thu 11/1210:45 am -
2 stops12h 15m
Deal found 9/3![Southwest logo]()
$313
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/301:30 pm -
1 stop6h 38m
Wed 10/76:30 am -
1 stop5h 12m
Deal found 9/8![American Airlines logo]()
$325
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/75:20 am -
2 stops6h 35m
Wed 11/113:25 pm -
2 stops7h 35m
Deal found 9/8![Southwest logo]()
$335
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/711:09 am -
1 stop4h 14m
Wed 11/118:07 am -
2 stops11h 49m
Deal found 9/3![American Airlines logo]()
$356
This Delta deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/305:45 am -
1 stop6h 48m
Wed 10/76:58 pm -
1 stop4h 35m
Deal found 9/4![Delta logo]()
$378
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/214:12 pm -
1 stop5h 40m
Sun 10/258:12 pm -
1 stop4h 46m
Deal found 9/5![American Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/278:00 am -
2 stops8h 11m
Sat 10/3111:27 am -
2 stops11h 28m
Deal found 9/3![United Airlines logo]()
$401
Best flights from Des Moines to Myrtle BeachDiscover carefully curated flight deals from Des Moines to Myrtle Beach that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 8, 2026.
Discover carefully curated flight deals from Des Moines to Myrtle Beach that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 8, 2026.
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/75:20 am -
2 stops6h 35m
Wed 11/113:25 pm -
2 stops7h 35m
Deal found 9/8![Southwest logo]()
$335
This Delta deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/305:45 am -
1 stop6h 48m
Wed 10/76:58 pm -
1 stop4h 35m
Deal found 9/4![Delta logo]()
$378
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:00 am -
2 stops9h 23m
Wed 11/1112:02 pm -
2 stops10h 17m
Deal found 9/8![American Airlines logo]()
$411
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/278:00 am -
2 stops8h 11m
Sat 10/3111:27 am -
2 stops11h 28m
Deal found 9/5![United Airlines logo]()
$472
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/32:58 pm -
1 stop6h 49m
Sun 12/611:26 am -
1 stop6h 23m
Deal found 9/7![Delta logo]()
$381
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/212:01 pm -
2 stops7h 01m
Sun 10/258:12 pm -
1 stop4h 46m
Deal found 9/5![American Airlines logo]()
$414
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:00 am -
2 stops9h 55m
Wed 10/76:30 am -
2 stops8h 00m
Deal found 9/4![American Airlines logo]()
$437
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:25 am -
2 stops13h 35m
Sun 11/810:45 am -
2 stops12h 15m
Deal found 9/3![Southwest logo]()
$558
Last-minute flights from Des Moines to Myrtle BeachDiscover last-minute flight deals from Des Moines to Myrtle Beach. Data last updated September 8, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Myrtle Beach. Data last updated September 8, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/301:30 pm -
1 stop6h 38m
Wed 10/76:30 am -
1 stop5h 12m
Deal found 9/8![American Airlines logo]()
$325
This Delta deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/305:45 am -
1 stop6h 48m
Wed 10/76:58 pm -
1 stop4h 35m
Deal found 9/4![Delta logo]()
$378
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/179:00 am -
2 stops29h 02m
Thu 10/229:32 am -
1 stop6h 10m
Deal found 9/8![Multiple Airlines logo]()
$405
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/214:12 pm -
1 stop5h 40m
Sun 10/258:12 pm -
1 stop4h 46m
Deal found 9/5![American Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/278:00 am -
2 stops8h 11m
Sat 10/3111:27 am -
2 stops11h 28m
Deal found 9/3![United Airlines logo]()
$401
One-way flights from Des Moines to Myrtle BeachSearch for one-way flight options from Des Moines to Myrtle Beach. Find affordable one-way fares based on user searches. Data last updated September 8, 2026.
Search for one-way flight options from Des Moines to Myrtle Beach. Find affordable one-way fares based on user searches. Data last updated September 8, 2026.
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/195:30 am -
1 stop4h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Southwest logo]()
$394
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/198:00 am -
3 stops47h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Multiple Airlines logo]()
$537
Find flight deals from Des Moines to Myrtle Beach
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Myrtle Beach (MYR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 8, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $297 (American Airlines) |
Popular in | July |
Cheapest in | January |
Average price | $361 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Myrtle Beach that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 8, 2026.
Use the filters below to find and compare flights from Des Moines to Myrtle Beach that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesMyrtle Beach
DSM Des Moines - MYR Myrtle Beach Intl
DSMMYR
Des Moines
Sat 11/7
5:20 am-12:55 pm
2 stops6h 35m
Myrtle Beach Intl
Wed 11/11
3:25 pm-10:00 pm
2 stops7h 35m
$335
Des MoinesMyrtle Beach
DSM Des Moines - MYR Myrtle Beach Intl
DSMMYR
Des Moines
Wed 9/30
5:45 am-1:33 pm
1 stop6h 48m
Myrtle Beach Intl
Wed 10/7
6:58 pm-10:33 pm
1 stop4h 35m
$378
Des MoinesMyrtle Beach
DSM Des Moines - MYR Myrtle Beach Intl
DSMMYR
Des Moines
Thu 12/3
2:58 pm-10:47 pm
1 stop6h 49m
Myrtle Beach Intl
Sun 12/6
11:26 am-4:49 pm
1 stop6h 23m
$381
Quickest round-trip
Des MoinesMyrtle Beach
DSM Des Moines - MYR Myrtle Beach Intl
DSMMYR
Des Moines
Sat 9/19
5:30 am-11:05 am
1 stop4h 35m
Myrtle Beach Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$394
Des MoinesMyrtle Beach
DSM Des Moines - MYR Myrtle Beach Intl
DSMMYR
Des Moines
Sat 11/7
6:00 am-4:23 pm
2 stops9h 23m
Myrtle Beach Intl
Wed 11/11
12:02 pm-9:19 pm
2 stops10h 17m
$411
Des MoinesMyrtle Beach
DSM Des Moines - MYR Myrtle Beach Intl
DSMMYR
Des Moines
Wed 10/21
2:01 pm-10:02 pm
2 stops7h 01m
Myrtle Beach Intl
Sun 10/25
8:12 pm-11:58 pm
1 stop4h 46m
$414
Des MoinesMyrtle Beach
DSM Des Moines - MYR Myrtle Beach Intl
DSMMYR
Des Moines
Wed 9/30
6:00 am-4:55 pm
2 stops9h 55m
Myrtle Beach Intl
Wed 10/7
6:30 am-1:30 pm
2 stops8h 00m
$437
Des MoinesMyrtle Beach
DSM Des Moines - MYR Myrtle Beach Intl
DSMMYR
Des Moines
Tue 10/27
8:00 am-5:11 pm
2 stops8h 11m
Myrtle Beach Intl
Sat 10/31
11:27 am-9:55 pm
2 stops11h 28m
$472
Des MoinesMyrtle Beach
DSM Des Moines - MYR Myrtle Beach Intl
DSMMYR
Des Moines
Sun 11/1
5:25 am-8:00 pm
2 stops13h 35m
Myrtle Beach Intl
Sun 11/8
10:45 am-10:00 pm
2 stops12h 15m
$558
Sorted by cheapest first
Compare providers for flights from Des Moines to Myrtle Beach
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Myrtle Beach in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Myrtle Beach flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Myrtle Beach flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Myrtle Beach flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Myrtle Beach flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Myrtle Beach flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Myrtle Beach
Have a flexible travel schedule? Discover the best time to fly to Myrtle Beach from Des Moines with our price prediction graph.
DSM-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Myrtle Beach
What is the cheapest month to book a flight from Des Moines to Myrtle Beach?
Currently, January is the cheapest month in which you can book a flight from Des Moines to Myrtle Beach (average of $293). Flying from Des Moines to Myrtle Beach in July is currently the most expensive (average of $486). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Myrtle Beach?
Airfare is below average for this route at the moment.
Des Moines to Myrtle Beach flights typically cost between $316 and $370 in November.The cheapest round-trip price found within the last 5 days was $297 on American Airlines (Nov 7-Nov 11).
Reviews of airlines servicing Myrtle Beach
Get insights into the airlines that provide service to Myrtle Beach. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Myrtle Beach. Reviews last updated September 8, 2026.
See what other customers who have flown with Southwest,Delta, andAmerican Airlines from Des Moines to Myrtle Beach have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Overall
8.0
Comfort
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Food
7.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Overall
8.0
Comfort
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Food
7.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Overall
8.0
Comfort
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Food
7.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Overall
8.0
Comfort
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Myrtle Beach. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Myrtle Beach?
Book flights to Myrtle Beach if you plan to visit one of these locationsConway
Pawleys Island
Sunset Beach
Surfside Beach
Garden City Beach
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Complete your trip
Complete your trip to Myrtle Beach by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Des Moines to Myrtle Beach by cabin class
Find flights from Des Moines to Myrtle Beach, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Myrtle Beach
Explore flights to Myrtle Beach departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 8, 2026.
Des Moines and Myrtle Beach flights
Browse other Des Moines and Myrtle Beach flight options. Last updated on September 8, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on September 8, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Des Moines to Myrtle Beach
Discover the top 3 airlines that operate flights from Des Moines to Myrtle Beach. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 8, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$292 | Average$390 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$334 | Average$396 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$344 | Average$412 | FlexibilityNo cancel fee | On-time63% |