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Myrtle Beach

$204+ Cheap flights from Des Moines to Myrtle Beach (DSM - MYR)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/13. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MYR
May 27 — Jun 31
Wed 5/27
Wed 6/3
1 adult, Economy
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1. Tell us where you want to go

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Cheap flight deals from Des Moines to Myrtle Beach

Cheapest flights from Des Moines to Myrtle Beach
Explore the most affordable flight options available from Des Moines to Myrtle Beach. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 27, 2026.

This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:30 pm
DSM
-
MYR
1 stop4h 09m
Delta
Wed 9/911:10 am
MYR
-
DSM
1 stop6h 39m
Delta
Deal found 4/22$263
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:30 pm
DSM
-
MYR
1 stop4h 09m
Delta
Thu 9/106:45 pm
MYR
-
DSM
1 stop4h 41m
Delta
Deal found 4/22$290
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
-
MYR
2 stops26h 55m
Multiple Airlines
Mon 6/86:00 am
MYR
-
DSM
1 stop18h 27m
Multiple Airlines
Deal found 4/25$291
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
-
MYR
2 stops26h 55m
Multiple Airlines
Thu 6/43:43 pm
MYR
-
DSM
1 stop23h 07m
Multiple Airlines
Deal found 4/25$295
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
-
MYR
2 stops26h 55m
Multiple Airlines
Fri 6/56:00 am
MYR
-
DSM
1 stop18h 27m
Multiple Airlines
Deal found 4/25$302
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:01 am
DSM
-
MYR
1 stop6h 29m
Delta
Sat 5/166:00 am
MYR
-
DSM
1 stop6h 08m
Delta
Deal found 4/22$304
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/293:57 pm
DSM
-
MYR
1 stop27h 39m
Multiple Airlines
Sat 6/66:30 am
MYR
-
DSM
2 stops41h 22m
Multiple Airlines
Deal found 4/25$307
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/135:44 am
DSM
-
MYR
1 stop5h 20m
American Airlines
Sat 5/165:00 am
MYR
-
DSM
2 stops6h 31m
American Airlines
Deal found 4/22$309
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/293:57 pm
DSM
-
MYR
1 stop27h 39m
Multiple Airlines
Thu 6/43:43 pm
MYR
-
DSM
1 stop23h 07m
Multiple Airlines
Deal found 4/25$313
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/85:45 am
DSM
-
MYR
1 stop6h 53m
Delta
Tue 9/86:45 pm
MYR
-
DSM
1 stop4h 41m
Delta
Deal found 4/22$317
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/13:57 pm
DSM
-
MYR
2 stops21h 51m
Multiple Airlines
Mon 6/86:00 am
MYR
-
DSM
1 stop18h 27m
Multiple Airlines
Deal found 4/23$318
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/293:57 pm
DSM
-
MYR
1 stop27h 39m
Multiple Airlines
Fri 6/56:00 am
MYR
-
DSM
1 stop18h 27m
Multiple Airlines
Deal found 4/25$320

Find flight deals from Des Moines to Myrtle Beach

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Myrtle Beach (MYR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$263
(Delta)

One-way from

$204
(Southwest)

Popular in

June

Cheapest in

January

Average price

$417
Provider with most accurate pricing for Des Moines-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Myrtle Beach Intl flights.
Search Deals
From Des Moines to Myrtle Beach Intl
Search Deals
One-way flight from Des Moines to Myrtle Beach Intl
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($43 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Myrtle Beach that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 27, 2026.
Use the filters below to find and compare flights from Des Moines to Myrtle Beach that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Wed 5/13

7:01 am-2:30 pm

1 stop6h 29m

Myrtle Beach Intl

Sat 5/16

6:00 am-11:08 am

1 stop6h 08m

$304
Quickest round-trip

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Tue 6/9

6:39 pm-11:59 pm

1 stop4h 20m

Myrtle Beach Intl

Tue 6/16

1:54 pm-5:54 pm

1 stop5h 00m

$335

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Wed 9/23

6:30 pm-11:39 pm

1 stop4h 09m

Myrtle Beach Intl

Sat 9/26

6:00 am-10:14 am

1 stop5h 14m

$371

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Wed 9/16

7:15 am-7:10 pm

2 stops10h 55m

Myrtle Beach Intl

Sun 9/20

2:45 pm-10:35 pm

2 stops8h 50m

$381

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Thu 6/4

6:41 pm-11:58 pm

1 stop4h 17m

Myrtle Beach Intl

Thu 6/11

6:00 am-10:43 am

1 stop5h 43m

$381
Cheapest one-way
Quickest one-way

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Sat 6/13

3:35 pm-9:05 pm

1 stop4h 30m

$204

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Sat 6/13

5:06 pm-5:57 pm

3 stops23h 51m

$334

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/23

Sorted by cheapest first

Compare providers for flights from Des Moines to Myrtle Beach

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Myrtle Beach in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Myrtle Beach flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Myrtle Beach flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Myrtle Beach flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Myrtle Beach flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Myrtle Beach flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Myrtle Beach

Have a flexible travel schedule? Discover the best time to fly to Myrtle Beach from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Myrtle Beach

What is the cheapest month to book a flight from Des Moines to Myrtle Beach?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Myrtle Beach (average of $291). Flying from Des Moines to Myrtle Beach in June is currently the most expensive (average of $467). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Des Moines to Myrtle Beach?

Reviews of airlines servicing Myrtle Beach

Get insights into the airlines that provide service to Myrtle Beach. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Myrtle Beach. Reviews last updated April 27, 2026.
See what other customers who have flown with Southwest,Delta, andAmerican Airlines from Des Moines to Myrtle Beach have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,324 reviews

Overall

8.0

Comfort

8.0

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Southwest
8.0
Very good
4,324 reviews
Southwest
8.0
Very good
4,324 reviews

Overall

8.0

Comfort

8.0

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Delta
7.9
Good
8,463 reviews
Southwest
8.0
Very good
4,324 reviews

Overall

8.0

Comfort

8.0

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
American Airlines
7.1
Good
11,668 reviews
Southwest
8.0
Very good
4,324 reviews

Overall

8.0

Comfort

8.0

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Myrtle Beach. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Myrtle Beach?

    There are many flights that can get you from Des Moines to Myrtle Beach in 6h 29m. Fly via Delta to get the fastest option. Des Moines and Myrtle Beach are separated by a distance of 969 mi.

  • What are the cheapest airlines flying from Des Moines to Myrtle Beach round-trip?

    Our cheapest airline available from Des Moines to Myrtle Beach is American Airlines. Our recent data shows that you can find tickets from as low as $248 on this airline. Additional options worth looking into are Southwest and Delta, starting at $272 and $302 round-trip. American Airlines is currently priced 35% below the average price you’ll pay for this route.

  • Can I find deals for flights from Des Moines to Myrtle Beach that include hotel bookings?

    Yes. In addition to deals on Des Moines to Myrtle Beach flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Myrtle Beach?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Myrtle Beach.

  • Can I find deals for business class flights from Des Moines to Myrtle Beach?

    Yes. Cheapflights offers flight deals from Des Moines to Myrtle Beach by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Myrtle Beach?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Myrtle Beach (average of $291). Flying from Des Moines to Myrtle Beach in June is currently the most expensive (average of $467). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Myrtle Beach?

Book flights to Myrtle Beach if you plan to visit one of these locations
Conway
Surfside Beach
Pawleys Island
Little River
Garden City Beach

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Des Moines to Myrtle Beach

Discover the top 3 airlines that operate flights from Des Moines to Myrtle Beach. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$397FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$272Average$404FlexibilityNo cancel feeOn-time63%
DeltaCheapest$302Average$396FlexibilityNo cancel feeOn-timeN/A

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