$135+ Cheap flights from Des Moines (DSM) to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/31. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Nov 9 — Nov 161
Round-trip
1 adult, Economy
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Cheapest flights from Des Moines to South CarolinaExplore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 10, 2026.
Explore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 10, 2026.
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:26 pm -
1 stop6h 43m
Mon 11/24:13 pm -
1 stop7h 26m
Deal found 10/8![American Airlines logo]()
$269
This American Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:00 am -
1 stop5h 56m
Wed 11/115:03 pm -
1 stop7h 23m
Deal found 10/7![American Airlines logo]()
$269
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/93:01 pm -
1 stop5h 58m
Wed 11/1111:12 am -
2 stops9h 04m
Deal found 10/8![United Airlines logo]()
$274
This Southwest deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/75:20 am -
2 stops13h 15m
Wed 11/113:25 pm -
2 stops7h 40m
Deal found 10/5![Southwest logo]()
$286
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/115:30 am -
1 stop4h 38m
Sat 11/1412:00 pm -
1 stop4h 21m
Deal found 10/6![Delta logo]()
$315
This United Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:05 am -
2 stops7h 12m
Sat 11/145:37 pm -
1 stop5h 18m
Deal found 10/6![United Airlines logo]()
$320
This Kiwi.com deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:37 pm -
1 stop12h 26m
Thu 10/299:36 am -
1 stop6h 06m
Deal found 10/10![Multiple Airlines logo]()
$321
This American Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/47:23 am -
1 stop7h 01m
Mon 11/97:26 pm -
1 stop5h 00m
Deal found 10/10![American Airlines logo]()
$325
This Delta deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:53 pm -
1 stop3h 58m
Sun 12/135:35 am -
1 stop6h 14m
Deal found 10/7![Delta logo]()
$327
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/79:55 am -
2 stops8h 17m
Sat 11/143:29 pm -
1 stop4h 47m
Deal found 10/9![United Airlines logo]()
$330
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/98:00 am -
2 stops10h 23m
Sun 12/132:29 pm -
1 stop5h 50m
Deal found 10/7![United Airlines logo]()
$332
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:05 am -
2 stops7h 23m
Fri 11/1310:23 am -
2 stops8h 05m
Deal found 10/9![United Airlines logo]()
$335
Best flights from Des Moines to South CarolinaDiscover carefully curated flight deals from Des Moines to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 10, 2026.
Discover carefully curated flight deals from Des Moines to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 10, 2026.
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/74:07 pm -
1 stop6h 52m
Tue 11/108:00 am -
1 stop7h 13m
Deal found 10/6![Delta logo]()
$269
This American Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:26 pm -
1 stop6h 43m
Mon 11/24:13 pm -
1 stop7h 26m
Deal found 10/7![American Airlines logo]()
$269
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/18:00 am -
2 stops8h 48m
Fri 2/511:27 am -
2 stops10h 56m
Deal found 10/9![United Airlines logo]()
$335
This Southwest deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:00 am -
2 stops11h 25m
Mon 11/163:25 pm -
2 stops7h 40m
Deal found 10/8![Southwest logo]()
$372
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/271:02 pm -
1 stop6h 57m
Sat 3/64:50 pm -
1 stop6h 40m
Deal found 10/8![United Airlines logo]()
$343
This American Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/311:38 am -
1 stop7h 16m
Sun 12/65:08 am -
1 stop6h 50m
Deal found 10/5![American Airlines logo]()
$343
This United Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/66:15 am -
1 stop7h 01m
Tue 4/133:05 pm -
1 stop5h 20m
Deal found 10/5![United Airlines logo]()
$349
This Delta deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/125:15 pm -
1 stop5h 20m
Mon 2/1510:55 am -
1 stop6h 32m
Deal found 10/9![Delta logo]()
$417
This United Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/308:00 am -
1 stop4h 46m
Wed 2/312:50 pm -
1 stop8h 32m
Deal found 10/5![United Airlines logo]()
$369
This American Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates ” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:23 am -
2 stops8h 00m
Wed 11/111:52 pm -
2 stops9h 02m
Deal found 10/10![American Airlines logo]()
$415
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/303:10 pm -
1 stop4h 53m
Wed 2/36:30 am -
1 stop5h 11m
Deal found 10/8![United Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:52 pm -
1 stop4h 01m
Sun 11/225:35 am -
1 stop6h 09m
Deal found 10/5![Delta logo]()
$447
This Southwest deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:25 am -
2 stops13h 55m
Mon 11/91:40 pm -
2 stops10h 25m
Deal found 10/5![Southwest logo]()
$503
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:05 am -
2 stops6h 55m
Sun 11/16:42 pm -
1 stop6h 44m
Deal found 10/8![American Airlines logo]()
$422
This United Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/71:05 pm -
2 stops9h 54m
Tue 11/1011:12 am -
2 stops11h 43m
Deal found 10/6![United Airlines logo]()
$380
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/67:05 am -
1 stop4h 32m
Tue 4/133:44 pm -
1 stop7h 09m
Deal found 10/8![American Airlines logo]()
$433
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/148:00 am -
1 stop4h 46m
Mon 1/184:58 pm -
1 stop7h 16m
Deal found 10/8![United Airlines logo]()
$398
This American Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:26 pm -
2 stops15h 32m
Fri 11/135:54 pm -
1 stop7h 03m
Deal found 10/10![American Airlines logo]()
$452
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/78:00 am -
2 stops8h 11m
Wed 11/1111:27 am -
2 stops8h 49m
Deal found 10/7![United Airlines logo]()
$409
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/96:30 pm -
1 stop5h 15m
Tue 1/126:15 am -
2 stops10h 56m
Deal found 10/8![United Airlines logo]()
$420
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/296:30 pm -
1 stop5h 15m
Sat 2/132:30 pm -
1 stop7h 10m
Deal found 10/9![United Airlines logo]()
$427
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:00 am -
1 stop6h 16m
Tue 10/2711:27 am -
2 stops8h 49m
Deal found 10/8![United Airlines logo]()
$452
This United Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/278:00 am -
2 stops8h 11m
Sat 10/3111:27 am -
2 stops11h 28m
Deal found 10/6![United Airlines logo]()
$514
Last-minute flights from Des Moines to South CarolinaDiscover last-minute flight deals from Des Moines to South Carolina. Data last updated October 10, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to South Carolina. Data last updated October 10, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:37 pm -
1 stop12h 26m
Thu 10/299:36 am -
1 stop6h 06m
Deal found 10/10![Multiple Airlines logo]()
$321
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/275:35 am -
1 stop4h 08m
Mon 11/27:00 am -
1 stop4h 42m
Deal found 10/6![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:26 pm -
1 stop6h 43m
Mon 11/24:13 pm -
1 stop7h 26m
Deal found 10/8![American Airlines logo]()
$269
This American Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/47:23 am -
1 stop7h 01m
Mon 11/97:26 pm -
1 stop5h 00m
Deal found 10/10![American Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:00 am -
1 stop5h 56m
Wed 11/115:03 pm -
1 stop7h 23m
Deal found 10/7![American Airlines logo]()
$269
This Southwest deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/75:20 am -
2 stops13h 15m
Wed 11/113:25 pm -
2 stops7h 40m
Deal found 10/5![Southwest logo]()
$286
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/79:55 am -
2 stops8h 17m
Sat 11/143:29 pm -
1 stop4h 47m
Deal found 10/9![United Airlines logo]()
$330
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/93:01 pm -
1 stop5h 58m
Wed 11/1111:12 am -
2 stops9h 04m
Deal found 10/8![United Airlines logo]()
$274
This Southwest deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:25 am -
2 stops12h 05m
Wed 11/116:35 am -
2 stops8h 40m
Deal found 10/8![Southwest logo]()
$349
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:05 am -
2 stops7h 23m
Fri 11/1310:23 am -
2 stops8h 05m
Deal found 10/9![United Airlines logo]()
$335
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/115:30 am -
1 stop4h 38m
Sat 11/1412:00 pm -
1 stop4h 21m
Deal found 10/6![Delta logo]()
$315
This United Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:05 am -
2 stops7h 12m
Sat 11/145:37 pm -
1 stop5h 18m
Deal found 10/6![United Airlines logo]()
$320
One-way flights from Des Moines to South CarolinaSearch for one-way flight options from Des Moines to South Carolina. Find affordable one-way fares based on user searches. Data last updated October 10, 2026.
Search for one-way flight options from Des Moines to South Carolina. Find affordable one-way fares based on user searches. Data last updated October 10, 2026.
This Delta deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3111:27 am -
1 stop7h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![Delta logo]()
$135
This Kiwi.com deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/124:15 pm -
2 stops26h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![Multiple Airlines logo]()
$136
This United Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:05 am -
2 stops7h 23m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![United Airlines logo]()
$140
This United Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/79:55 am -
1 stop7h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/10![United Airlines logo]()
$163
This American Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:00 am -
1 stop8h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/10![American Airlines logo]()
$163
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/319:36 am -
2 stops8h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![United Airlines logo]()
$170
This American Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:26 pm -
1 stop6h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![American Airlines logo]()
$172
This American Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/245:05 am -
1 stop8h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![American Airlines logo]()
$188
This Kiwi.com deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:48 pm -
3 stops41h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![Multiple Airlines logo]()
$207
This Southwest deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/246:00 am -
2 stops10h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/5![Southwest logo]()
$214
This American Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/211:58 pm -
2 stops8h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/5![American Airlines logo]()
$214
This American Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/247:02 am -
1 stop6h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/5![American Airlines logo]()
$284
Find flight deals from Des Moines to South Carolina
Keep the following information in mind while searching for Des Moines to South Carolina flight deals. Data was last updated October 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $269 (American Airlines) |
One-way from | $135 (Delta) |
Popular in | July |
Cheapest in | January |
Average price | $353 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 10, 2026.
Use the filters below to find and compare flights from Des Moines to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Sat 10/31
11:27 am-7:48 pm
1 stop7h 21m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$135
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Tue 11/24
9:31 am-3:20 pm
1 stop4h 49m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$135
Des MoinesGreenville
DSM Des Moines - GSP Greenville
DSMGSP
Des Moines
Thu 11/12
4:15 pm-8:13 am
1 stop14h 58m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$136
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Mon 11/23
6:05 am-2:28 pm
2 stops7h 23m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$140
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Sat 11/7
9:55 am-6:06 pm
1 stop7h 11m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$163
Des MoinesGreenville
DSM Des Moines - GSP Greenville
DSMGSP
Des Moines
Thu 11/12
6:00 am-3:05 pm
1 stop8h 05m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$163
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Sat 10/31
9:36 am-7:12 pm
2 stops8h 36m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$170
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Thu 12/24
5:05 am-2:49 pm
1 stop8h 44m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$188
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Thu 12/24
6:00 am-5:25 pm
2 stops10h 25m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$193
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Wed 11/4
7:00 am-7:35 pm
2 stops11h 35m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$215
Showing 1-10 of 43 resultsSorted by cheapest first
Best time to book a flight from Des Moines to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Des Moines with our price prediction graph.
DSM-CHS
DSM-MYR
DSM-HHH
DSM-GSP
DSM-CAE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to South Carolina
DSM-USSC
DSM-CHS
DSM-MYR
DSM-HHH
DSM-GSP
What is the cheapest month to book a flight from Des Moines to South Carolina?
Currently, January is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $386). Flying from Des Moines to South Carolina in March is currently the most expensive (average of $502). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to South Carolina?
Airfare is below average for this route at the moment.
Des Moines to South Carolina flights typically cost between $380 and $596 in October.The cheapest round-trip price found within the last 5 days was $269 on American Airlines (Oct 29-Nov 2).
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated October 10, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Des Moines to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
8.0
Entertainment
7.4
Food
7.0
Overall
7.9
Crew
8.6
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Boarding
8.1
Comfort
8.0
Entertainment
7.4
Food
7.0
Overall
7.9
Crew
8.6
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Boarding
8.1
Comfort
8.0
Entertainment
7.4
Food
7.0
Overall
7.9
Crew
8.6
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Boarding
8.1
Comfort
8.0
Entertainment
7.4
Food
7.0
Overall
7.9
Crew
8.6
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Boarding
8.1
Comfort
8.0
Entertainment
7.4
Food
7.0
Overall
7.9
Crew
8.6
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Related info for your journey
Find useful and relevant information for your journey from Des Moines to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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Des Moines and South Carolina flights
Browse other Des Moines and South Carolina flight options. Last updated on October 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Des Moines to South Carolina flights
Consider these flights traveling from Des Moines to South Carolina.
Top 4 airlines flying from Des Moines to South Carolina
Discover the top 4 airlines that operate flights from Des Moines to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$266 | Average$459 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$292 | Average$433 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$308 | Average$441 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$344 | Average$443 | FlexibilityNo cancel fee | On-time63% |