HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$109+ Cheap flights from Des Moines (DSM) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/1. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
jul. 7 — jul. 141
lun. 7/7
lun. 7/14
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Des Moines to South Carolina

Keep the following information in mind while searching for Des Moines to South Carolina flight deals. Data was last updated julio 2, 2025.

Round-trip from

$219
(Mytrip)

One-way from

$109
(Mytrip)

Popular in

June

Cheapest in

September

Average price

$410
From Des Moines to South Carolina
Search Deals
One-way flight from Des Moines to South Carolina
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($46 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2025
Search Deals

Find flight deals from Des Moines to South Carolina

Cheapest flights from Des Moines to South Carolina
Explore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 2, 2025.

This Mytrip deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 7/212:00 pmDSM - CLT
2 stops22h 40mMultiple Airlines
vie. 8/89:24 amCLT - DSM
1 stop9h 41mMultiple Airlines
Deal found 6/30$219
This Southwest deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/147:00 amDSM - CLT
1 stop7h 15mSouthwest
mar. 8/195:25 pmCLT - DSM
1 stop5h 55mSouthwest
Deal found 6/30$236
This Delta deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/273:12 pmDSM - CHS
1 stop6h 14mDelta
lun. 9/15:15 amCHS - DSM
1 stop6h 23mDelta
Deal found 7/2$237
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/1410:18 amDSM - GSP
1 stop6h 26mDelta
jue. 8/215:59 pmGSP - DSM
1 stop5h 40mDelta
Deal found 6/30$237
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/116:30 pmDSM - MYR
1 stop4h 19mDelta
lun. 9/1512:35 pmMYR - DSM
1 stop7h 39mDelta
Deal found 6/30$237
This United Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/202:58 pmDSM - SAV
1 stop6h 01mUnited Airlines
lun. 8/2510:09 amSAV - DSM
1 stop5h 01mUnited Airlines
Deal found 6/30$237
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/147:00 amDSM - CHS
1 stop4h 16mAmerican Airlines
jue. 8/216:06 pmCHS - DSM
1 stop6h 39mAmerican Airlines
Deal found 6/30$238
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/117:08 amDSM - GSP
2 stops7h 26mAmerican Airlines
mar. 9/1611:27 amGSP - DSM
1 stop4h 53mAmerican Airlines
Deal found 6/30$242
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/117:08 amDSM - MYR
2 stops9h 12mAmerican Airlines
lun. 9/157:36 pmMYR - DSM
1 stop4h 30mAmerican Airlines
Deal found 6/30$242
This Southwest deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/206:30 amDSM - SAV
2 stops9h 55mSouthwest
lun. 8/2512:35 pmSAV - DSM
2 stops8h 45mSouthwest
Deal found 6/30$247
This Southwest deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 9/206:10 amDSM - MYR
1 stop7h 50mSouthwest
lun. 9/298:25 amMYR - DSM
2 stops12h 55mSouthwest
Deal found 6/30$248
This United Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 7/296:24 amDSM - GSP
2 stops9h 39mUnited Airlines
mar. 8/55:35 pmGSP - DSM
1 stop5h 12mUnited Airlines
Deal found 7/1$249

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 2, 2025.
Use the filters below to find and compare flights from Des Moines to South Carolina that are best for you.

Fly from

Des Moines

Fly to

South Carolina

Route

Depart

Return

Price

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

lun. 7/21

2:00 pm-1:40 pm

2 stops22h 40m

Charlotte Douglas

vie. 8/8

9:24 am-6:05 pm

1 stop9h 41m

$219

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

jue. 8/14

7:00 am-3:15 pm

1 stop7h 15m

Charlotte Douglas

mar. 8/19

5:25 pm-10:20 pm

1 stop5h 55m

$236

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

mié. 8/27

3:12 pm-10:26 pm

1 stop6h 14m

Charleston

lun. 9/1

5:15 am-10:38 am

1 stop6h 23m

$237

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

mié. 8/20

2:58 pm-9:59 pm

1 stop6h 01m

Savannah/Hilton Head

lun. 8/25

10:09 am-2:10 pm

1 stop5h 01m

$237

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

jue. 8/14

10:18 am-5:44 pm

1 stop6h 26m

Greenville

jue. 8/21

11:17 am-4:45 pm

1 stop6h 28m

$237

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

jue. 9/11

6:30 pm-11:49 pm

1 stop4h 19m

Myrtle Beach Intl

lun. 9/15

12:35 pm-7:14 pm

1 stop7h 39m

$237

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

jue. 8/14

7:00 am-12:16 pm

1 stop4h 16m

Charleston

jue. 8/21

6:06 pm-11:45 pm

1 stop6h 39m

$238

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

jue. 9/11

7:08 am-3:34 pm

2 stops7h 26m

Greenville

mar. 9/16

11:27 am-3:20 pm

1 stop4h 53m

$242

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

jue. 9/11

7:08 am-5:20 pm

2 stops9h 12m

Myrtle Beach Intl

lun. 9/15

7:36 pm-11:06 pm

1 stop4h 30m

$242

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

mié. 8/20

6:30 am-5:25 pm

2 stops9h 55m

Savannah/Hilton Head

lun. 8/25

12:35 pm-8:20 pm

2 stops8h 45m

$247

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/30

Showing 1-10 of 51 results
1
2
3
...
6

Best time to book a flight from Des Moines to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to South Carolina

What is the cheapest month to book a flight from Des Moines to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $217). Flying from Des Moines to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to SC?

Find hourly flight availability from Des Moines to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated julio 2, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to South Carolina as you normally would.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated julio 2, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Des Moines to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,272 reviews

Crew

8.6

Overall

8.0

Boarding

8.2

Comfort

8.0

Food

7.0

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Southwest
8.0
Very good
4,272 reviews
Southwest
8.0
Very good
4,272 reviews

Crew

8.6

Overall

8.0

Boarding

8.2

Comfort

8.0

Food

7.0

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Delta
8.0
Very good
7,975 reviews
Southwest
8.0
Very good
4,272 reviews

Crew

8.6

Overall

8.0

Boarding

8.2

Comfort

8.0

Food

7.0

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
United Airlines
7.4
Good
8,861 reviews
Southwest
8.0
Very good
4,272 reviews

Crew

8.6

Overall

8.0

Boarding

8.2

Comfort

8.0

Food

7.0

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,272 reviews

Crew

8.6

Overall

8.0

Boarding

8.2

Comfort

8.0

Food

7.0

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Allegiant Air
7.2
Good
709 reviews
Southwest
8.0
Very good
4,272 reviews

Crew

8.6

Overall

8.0

Boarding

8.2

Comfort

8.0

Food

7.0

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to South Carolina?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to South Carolina.

  • What are the cheapest airlines to fly from Des Moines to South Carolina one-way?

    For one-way options, check prices for Allegiant Air. According to our data, you can fly for as low as $109. Users have also found prices from $119 and $124 on American Airlines and Delta, respectively.

  • What are the most popular routes from Des Moines to South Carolina?

    When deciding which route to take from Des Moines to South Carolina consider Des Moines - Charlotte Douglas, Des Moines - Charleston or Des Moines - Myrtle Beach Intl as they are the most popular.

  • Can I find deals for flights from Des Moines to South Carolina that include hotel bookings?

    Yes. In addition to deals on Des Moines to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to South Carolina.

  • Can I find deals for business class flights from Des Moines to South Carolina?

    Yes. Cheapflights offers flight deals from Des Moines to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $217). Flying from Des Moines to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
Omaha to Seattle flights
Omaha to Dallas/Fort Worth flights
Cedar Rapids to Seattle flights
Des Moines to Denver flights
Omaha to O'Hare Intl flights
Omaha to Las Vegas flights
Omaha to San Francisco flights
Omaha to Denver flights
Omaha to LaGuardia flights
Des Moines to LaGuardia flights
Cedar Rapids to Denver flights
Omaha to Hobby flights
Omaha to Key West flights
Omaha to Nashville flights
Des Moines to Seattle flights
Des Moines to Sky Harbor Intl flights
Cedar Rapids to Dallas/Fort Worth flights
Omaha to Orlando flights
Omaha to Love Field flights
Des Moines to Dallas/Fort Worth flights
Omaha to John F Kennedy Intl flights
Des Moines to Las Vegas flights
Cedar Rapids to Orlando flights
Omaha to Los Angeles flights
Omaha to George Bush Intcntl flights
Cedar Rapids to John F Kennedy Intl flights
Des Moines to O'Hare Intl flights
Des Moines to Orlando flights
Omaha to Miami flights
Omaha to Reagan-National flights
Des Moines to John F Kennedy Intl flights
Moline to Denver flights
Omaha to San Diego flights
Omaha to Burbank flights
Omaha to Newark flights
Cedar Rapids to Norfolk flights
Omaha to Dulles Intl flights
Omaha to Atlanta flights
Cedar Rapids to LaGuardia flights
Omaha to Myrtle Beach flights
Moline to Orlando flights
Des Moines to Dulles Intl flights
Cedar Rapids to Newark flights
Omaha to Salt Lake City flights
Cedar Rapids to Hobby flights
Cedar Rapids to Fort Lauderdale flights
Des Moines to Charlotte flights
Cedar Rapids to Sky Harbor Intl flights
Omaha to Milwaukee flights
Des Moines to Reagan-National flights

Top 4 airlines flying from Des Moines to South Carolina

Discover the top 4 airlines that operate flights from Des Moines to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$237Average$395FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$258Average$380FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$315Average$565FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$376Average$406FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.