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Cheap flights from Des Moines (DSM) to South Carolina from $81

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/18. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
DSM — CHS
Apr 28 — May 51
From?
To?
Sun 4/28
Sun 5/5
1 adult, Economy
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How far in advance should I book a flight from Des Moines to South Carolina?

To save on the cost of your flight from Des Moines to South Carolina, book at least 49 days before your planned departure. Booking around this time can save you about 128% on the cost of this flight compared to booking a flight leaving this week. We have found prices from $454 if you need a flight within two weeks. For flights within the next 72 hours, you can find tickets from as low as $756.

What is the cheapest month to fly from Des Moines to South Carolina?

The best pricing can be found in the month of January. Prices to South Carolina from Des Moines average $394. You can even find prices in January for less than $394, as users have found deals to South Carolina from as low as $279. The month of June appears to be one of the more expensive times to travel to South Carolina from Des Moines. Flying in the targeted month can save you up to 25%.

When is the cheapest time to fly from Des Moines to South Carolina (DSM - SC)?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to South Carolina as you normally would.

Cheap Frontier flights from Des Moines to South Carolina

Explore cheap flight options specifically provided by Frontier for the route between Des Moines and South Carolina. Find affordable fares and compare prices with other airlines to secure the best deal for your journey. Over the last 7 days, Cheapflights users made 3,086,534 searches. Data last updated April 23, 2024.
Take a look at some of the lowest-priced Frontier flights heading from Des Moines to South Carolina. Make sure to double check the flight details before booking.
Mon 5/134:06 pmDSM - CLT
1 stop19h 07mFrontier
Fri 5/179:02 pmCLT - DSM
1 stop24h 31mFrontier
Deal found 4/22$163
Sat 8/249:15 pmDSM - CLT
1 stop12h 37mFrontier
Wed 8/287:32 pmCLT - DSM
1 stop25h 43mFrontier
Deal found 4/22$171
Mon 5/134:06 pmDSM - CLT
1 stop19h 07mFrontier
Tue 5/215:37 pmCLT - DSM
1 stop22h 38mFrontier
Deal found 4/22$173
Fri 5/105:17 pmDSM - CLT
1 stop17h 56mFrontier
Mon 5/139:05 amCLT - DSM
1 stop7h 11mFrontier
Deal found 4/22$177
Thu 6/136:57 pmDSM - CLT
1 stop12h 25mFrontier
Sun 6/161:34 pmCLT - DSM
1 stop5h 58mFrontier
Deal found 4/22$199
Fri 6/149:17 pmDSM - CLT
1 stop12h 30mFrontier
Sun 6/161:34 pmCLT - DSM
1 stop5h 58mFrontier
Deal found 4/22$232
Wed 6/194:22 pmDSM - CLT
1 stop17h 05mFrontier
Fri 6/219:14 pmCLT - DSM
1 stop24h 07mFrontier
Deal found 4/22$238
Sat 9/219:15 pmDSM - CLT
1 stop12h 37mFrontier
Tue 10/87:12 pmCLT - DSM
1 stop26h 03mFrontier
Deal found 4/22$247
Thu 6/206:57 pmDSM - CLT
1 stop12h 25mFrontier
Sun 6/231:34 pmCLT - DSM
1 stop5h 58mFrontier
Deal found 4/22$257

Cheap American Airlines flights from Des Moines to South Carolina

Explore cheap flight options specifically provided by American Airlines for the route between Des Moines and South Carolina. Find affordable fares and compare prices with other airlines to secure the best deal for your journey. Over the last 7 days, Cheapflights users made 3,086,534 searches. Data last updated April 23, 2024.
Have a look at some of the cheapest available American Airlines flights departing from Des Moines and landing in South Carolina. Make sure to examine the flight information before completing your reservation.
Wed 8/147:10 amDSM - CAE
1 stop5h 52mAmerican Airlines
Sat 8/176:35 pmCAE - DSM
1 stop4h 03mAmerican Airlines
Deal found 4/22$195
Wed 8/146:18 amDSM - CAE
2 stops6h 44mAmerican Airlines
Sat 8/176:35 pmCAE - DSM
1 stop4h 03mAmerican Airlines
Deal found 4/22$201
Tue 8/64:10 pmDSM - CAE
1 stop6h 47mAmerican Airlines
Sat 8/106:35 pmCAE - DSM
1 stop4h 03mAmerican Airlines
Deal found 4/22$238
Tue 8/64:10 pmDSM - CAE
1 stop6h 47mAmerican Airlines
Sat 8/102:40 pmCAE - DSM
2 stops7h 54mAmerican Airlines
Deal found 4/22$243
Wed 8/146:18 amDSM - CAE
2 stops6h 44mAmerican Airlines
Sat 8/172:40 pmCAE - DSM
2 stops7h 47mAmerican Airlines
Deal found 4/22$248
Tue 8/207:10 amDSM - MYR
1 stop5h 52mAmerican Airlines
Wed 8/284:13 pmMYR - DSM
1 stop6h 25mAmerican Airlines
Deal found 4/22$253
Sat 9/79:40 amDSM - CHS
1 stop7h 17mAmerican Airlines
Sat 9/2811:17 amCHS - DSM
1 stop4h 16mAmerican Airlines
Deal found 4/22$254
Wed 5/86:40 amDSM - CAE
1 stop6h 25mAmerican Airlines
Sat 5/117:02 amCAE - DSM
1 stop6h 20mAmerican Airlines
Deal found 4/22$255
Thu 5/306:40 amDSM - GSP
1 stop4h 32mAmerican Airlines
Sat 6/16:00 amGSP - DSM
1 stop7h 22mAmerican Airlines
Deal found 4/22$256

Cheap Des Moines to South Carolina flights in April & May 2024

Find cheap flight options from Des Moines to South Carolina specifically for the months of April and May 2024. Explore affordable fares based on user searches. Over the last 7 days, Cheapflights users made 3,086,534 searches. Prices were last updated on April 23, 2024.
These are some of the best deals we've found on flights to South Carolina in 2024 at this time. For more flight deals, be sure to check back very soon.
Mon 5/134:06 pmDSM - CLT
1 stop19h 07mFrontier
Fri 5/179:02 pmCLT - DSM
1 stop24h 31mFrontier
Deal found 4/22$163
Mon 5/134:06 pmDSM - CLT
1 stop19h 07mFrontier
Tue 5/215:37 pmCLT - DSM
1 stop22h 38mFrontier
Deal found 4/22$173
Fri 5/105:17 pmDSM - CLT
1 stop17h 56mFrontier
Mon 5/139:05 amCLT - DSM
1 stop7h 11mFrontier
Deal found 4/22$177
Mon 5/62:11 pmDSM - CAE
1 stop7h 00mDelta
Tue 5/147:00 amCAE - DSM
1 stop5h 05mDelta
Deal found 4/22$237
Sun 5/56:09 pmDSM - CAE
1 stop4h 50mDelta
Tue 5/147:00 amCAE - DSM
1 stop5h 05mDelta
Deal found 4/22$249
Wed 5/86:40 amDSM - CAE
1 stop6h 25mAmerican Airlines
Sat 5/117:02 amCAE - DSM
1 stop6h 20mAmerican Airlines
Deal found 4/22$255
Thu 5/306:40 amDSM - GSP
1 stop4h 32mAmerican Airlines
Sat 6/16:00 amGSP - DSM
1 stop7h 22mAmerican Airlines
Deal found 4/22$256
Thu 5/96:14 pmDSM - CAE
1 stop4h 43mDelta
Sat 5/116:00 amCAE - DSM
1 stop6h 05mDelta
Deal found 4/22$258
Wed 5/86:40 amDSM - CAE
1 stop6h 25mAmerican Airlines
Sat 5/115:19 amCAE - DSM
2 stops7h 17mAmerican Airlines
Deal found 4/22$260

Des Moines to South Carolina 2024 flight deals

Discover exclusive flight deals for travel between Des Moines and South Carolina in 2024. Find excellent offers based on user searches. Over the last 7 days, Cheapflights users made 3,086,534 searches. Data last updated April 23, 2024.
These are some of the best deals we've found on flights to South Carolina in 2024 at this time. For more flight deals, be sure to check back very soon.
Mon 5/134:06 pmDSM - CLT
1 stop19h 07mFrontier
Fri 5/179:02 pmCLT - DSM
1 stop24h 31mFrontier
Deal found 4/22$163
Sat 8/249:15 pmDSM - CLT
1 stop12h 37mFrontier
Wed 8/287:32 pmCLT - DSM
1 stop25h 43mFrontier
Deal found 4/22$171
Mon 5/134:06 pmDSM - CLT
1 stop19h 07mFrontier
Tue 5/215:37 pmCLT - DSM
1 stop22h 38mFrontier
Deal found 4/22$173
Fri 5/105:17 pmDSM - CLT
1 stop17h 56mFrontier
Mon 5/139:05 amCLT - DSM
1 stop7h 11mFrontier
Deal found 4/22$177
Wed 8/147:10 amDSM - CAE
1 stop5h 52mAmerican Airlines
Sat 8/176:35 pmCAE - DSM
1 stop4h 03mAmerican Airlines
Deal found 4/22$195
Thu 6/136:57 pmDSM - CLT
1 stop12h 25mFrontier
Sun 6/161:34 pmCLT - DSM
1 stop5h 58mFrontier
Deal found 4/22$199
Wed 8/146:18 amDSM - CAE
2 stops6h 44mAmerican Airlines
Sat 8/176:35 pmCAE - DSM
1 stop4h 03mAmerican Airlines
Deal found 4/22$201
Fri 6/149:17 pmDSM - CLT
1 stop12h 30mFrontier
Sun 6/161:34 pmCLT - DSM
1 stop5h 58mFrontier
Deal found 4/22$232
Mon 5/62:11 pmDSM - CAE
1 stop7h 00mDelta
Tue 5/147:00 amCAE - DSM
1 stop5h 05mDelta
Deal found 4/22$237

Non-stop flights to South Carolina from Des Moines

Discover non-stop flight options from Des Moines to South Carolina. Find direct flights with no layovers, providing a convenient travel experience. Explore non-stop flight options based on user searches, and compare prices and availability for your desired travel dates. Over the last 7 days, Cheapflights users made 3,086,534 searches. Data last updated April 23, 2024.
Take a look at some of the direct flights traveling from Des Moines to South Carolina in the near future. Users can also choose from other Des Moines to South Carolina flights by using the search form above.
Sat 9/217:10 amDSM - CLT
Nonstop2h 20mAmerican Airlines
Tue 10/81:00 pmCLT - DSM
Nonstop2h 33mAmerican Airlines
Deal found 4/22$312
Thu 5/2312:23 pmDSM - CLT
Nonstop2h 21mAmerican Airlines
Tue 5/2810:15 amCLT - DSM
Nonstop2h 23mAmerican Airlines
Deal found 4/22$332
Wed 5/156:40 amDSM - CLT
Nonstop2h 22mAmerican Airlines
Sun 5/1910:15 amCLT - DSM
Nonstop2h 23mAmerican Airlines
Deal found 4/22$458
Mon 5/1312:23 pmDSM - CLT
Nonstop2h 21mAmerican Airlines
Sat 5/188:20 pmCLT - DSM
Nonstop2h 23mAmerican Airlines
Deal found 4/22$473
Wed 6/196:54 amDSM - CLT
Nonstop2h 21mAmerican Airlines
Fri 6/2110:33 pmCLT - DSM
Nonstop2h 32mAmerican Airlines
Deal found 4/22$488
Mon 5/1312:23 pmDSM - CLT
Nonstop2h 21mAmerican Airlines
Tue 5/218:19 pmCLT - DSM
Nonstop2h 23mAmerican Airlines
Deal found 4/22$549
Mon 6/174:02 pmDSM - CLT
Nonstop2h 22mAmerican Airlines
Fri 6/2110:33 pmCLT - DSM
Nonstop2h 32mAmerican Airlines
Deal found 4/22$594
Fri 5/106:40 amDSM - CLT
Nonstop2h 22mAmerican Airlines
Mon 5/1310:15 amCLT - DSM
Nonstop2h 23mAmerican Airlines
Deal found 4/22$596
Fri 5/31:00 pmDSM - CLT
Nonstop2h 17mAmerican Airlines
Sun 5/58:50 pmCLT - DSM
Nonstop2h 27mAmerican Airlines
Deal found 4/21$611

Des Moines to South Carolina flights leaving soon

Find last-minute flight options from Des Moines to South Carolina for spontaneous travel. Discover available flights and compare prices based on user searches. Secure great deals and offers for spontaneous trips with quick booking options. Over the last 7 days, Cheapflights users made 3,086,534 searches. Data last updated April 23, 2024.
Have a look at some of the flights available from Des Moines to South Carolina departing last-minute. Users should double check the flight they book to ensure it matches the day, time, and destination they're looking for.
Fri 5/34:23 pmDSM - CLT
2 stops22h 48mMultiple Airlines
Sun 5/57:48 amCLT - DSM
2 stops16h 17mMultiple Airlines
Deal found 4/21$338
Fri 5/37:55 amDSM - CLT
1 stop9h 34mMultiple Airlines
Sun 5/57:48 amCLT - DSM
2 stops16h 17mMultiple Airlines
Deal found 4/21$369
Fri 5/34:23 pmDSM - CLT
2 stops22h 48mMultiple Airlines
Sun 5/57:48 amCLT - DSM
3 stops32h 45mMultiple Airlines
Deal found 4/21$387
Fri 5/34:23 pmDSM - CLT
3 stops26h 22mMultiple Airlines
Sun 5/57:48 amCLT - DSM
3 stops32h 45mMultiple Airlines
Deal found 4/21$445
Fri 5/31:00 pmDSM - CAE
1 stop5h 21mAmerican Airlines
Sun 5/57:19 amCAE - DSM
1 stop5h 53mAmerican Airlines
Deal found 4/21$472
Thu 5/27:30 amDSM - CHS
1 stop8h 04mMultiple Airlines
Sat 5/411:45 amCHS - DSM
3 stops28h 25mMultiple Airlines
Deal found 4/21$481
Thu 5/28:30 amDSM - CHS
2 stops13h 06mMultiple Airlines
Sat 5/411:45 amCHS - DSM
3 stops28h 25mMultiple Airlines
Deal found 4/21$511
Mon 4/295:55 amDSM - CHS
1 stop4h 44mDelta
Wed 5/112:46 pmCHS - DSM
1 stop5h 31mDelta
Deal found 4/21$514
Mon 4/292:11 pmDSM - MYR
1 stop7h 40mDelta
Fri 5/35:43 pmMYR - DSM
1 stop6h 24mDelta
Deal found 4/21$514

One-way flights to South Carolina from Des Moines

Search for one-way flight options from Des Moines to South Carolina. Find affordable one-way fares based on user searches. Compare prices and availability to plan your one-way journey according to your preferred dates and budget. Over the last 7 days, Cheapflights users made 3,086,534 searches. Data last updated April 23, 2024.
Users in need of a one-way flight from Des Moines to South Carolina can choose from these deals. Users can also find round-trip Des Moines to South Carolina flights by using the search form above.
Sat 5/189:33 pmDSM - CLT
1 stop12h 19mFrontier
Deal found 4/22$81
Fri 5/179:34 pmDSM - CLT
1 stop21h 33mFrontier
Deal found 4/22$89
Wed 8/147:10 amDSM - CAE
1 stop5h 52mAmerican Airlines
Deal found 4/22$98
Wed 5/13:25 pmDSM - CLT
1 stop19h 48mFrontier
Deal found 4/22$100
Wed 8/146:18 amDSM - CAE
2 stops6h 44mAmerican Airlines
Deal found 4/22$104
Fri 5/179:00 amDSM - CLT
2 stops24h 58mMultiple Airlines
Deal found 4/22$153
Fri 5/176:40 amDSM - GSP
1 stop6h 06mAmerican Airlines
Deal found 4/22$165
Fri 5/179:00 amDSM - CLT
3 stops32h 35mMultiple Airlines
Deal found 4/22$178
Sat 5/186:00 amDSM - CLT
2 stops26h 46mUnited Airlines
Deal found 4/22$239

Find flights from Des Moines to South Carolina within your budget

Customize your flight search to find flights from Des Moines to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 3,086,534 searches. Data last updated April 23, 2024.

Fly from

Any airport

Fly to

Any airport

Budget

$163 - $412

Route

Depart

Return

Price

Des MoinesCharlotte Douglas

DSM - CLT

DSMCLT

Des Moines

Mon 5/13

1 stop19h 07m

Charlotte Douglas

Fri 5/17

1 stop24h 31m

$163

Des MoinesCharlotte Douglas

DSM - CLT

DSMCLT

Des Moines

Sat 8/24

1 stop12h 37m

Charlotte Douglas

Wed 8/28

1 stop25h 43m

$171

Des MoinesCharlotte Douglas

DSM - CLT

DSMCLT

Des Moines

Mon 5/13

1 stop19h 07m

Charlotte Douglas

Tue 5/21

1 stop22h 38m

$173

Des MoinesCharlotte Douglas

DSM - CLT

DSMCLT

Des Moines

Fri 5/10

1 stop17h 56m

Charlotte Douglas

Mon 5/13

1 stop7h 11m

$177

Des MoinesColumbia Metropolitan

DSM - CAE

DSMCAE

Des Moines

Wed 8/14

1 stop5h 52m

Columbia Metropolitan

Sat 8/17

1 stop4h 03m

$195

Des MoinesColumbia Metropolitan

DSM - CAE

DSMCAE

Des Moines

Wed 8/14

2 stops6h 44m

Columbia Metropolitan

Sat 8/17

1 stop4h 03m

$201

Des MoinesColumbia Metropolitan

DSM - CAE

DSMCAE

Des Moines

Mon 5/6

1 stop7h 00m

Columbia Metropolitan

Tue 5/14

1 stop5h 05m

$237

Des MoinesCharlotte Douglas

DSM - CLT

DSMCLT

Des Moines

Mon 6/17

1 stop15h 23m

Charlotte Douglas

Fri 6/21

2 stops11h 33m

$328

Des MoinesColumbia Metropolitan

DSM - CAE

DSMCAE

Des Moines

Thu 5/9

1 stop5h 29m

Columbia Metropolitan

Tue 5/14

2 stops15h 27m

$412

Flights are sorted by cheapest first

Deals found on 4/22

No data available for this route at this time. Please check back soon.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 23, 2024.
Get a feel of what it's like to fly with Frontier, American Airlines and United Airlines from Des Moines to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.1
Very good
11,028 reviews
Check prices

Comfort

7.9

Boarding

8.2

Crew

8.6

Entertainment

8.0

Overall

8.1

Food

7.5

Reviews

1 / 10

Terrible flight crew that skipped our row for service multiple times.

Delta
8.1
Very good
11,028 reviews
Delta
8.1
Very good
11,028 reviews
Check prices

Comfort

7.9

Boarding

8.2

Crew

8.6

Entertainment

8.0

Overall

8.1

Food

7.5

Reviews

1 / 10

Terrible flight crew that skipped our row for service multiple times.

United Airlines
7.4
Good
11,289 reviews
Delta
8.1
Very good
11,028 reviews
Check prices

Comfort

7.9

Boarding

8.2

Crew

8.6

Entertainment

8.0

Overall

8.1

Food

7.5

Reviews

1 / 10

Terrible flight crew that skipped our row for service multiple times.

American Airlines
7.3
Good
14,914 reviews
Delta
8.1
Very good
11,028 reviews
Check prices

Comfort

7.9

Boarding

8.2

Crew

8.6

Entertainment

8.0

Overall

8.1

Food

7.5

Reviews

1 / 10

Terrible flight crew that skipped our row for service multiple times.

Frontier
6.3
Okay
4,142 reviews
Delta
8.1
Very good
11,028 reviews
Check prices

Comfort

7.9

Boarding

8.2

Crew

8.6

Entertainment

8.0

Overall

8.1

Food

7.5

Reviews

1 / 10

Terrible flight crew that skipped our row for service multiple times.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to South Carolina?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to South Carolina.

  • Can I find flights from Des Moines to South Carolina for under $200 on Cheapflights?

    Yes, there are multiple flights from Des Moines to South Carolina for under $200. The cheapest flight booked recently is on Frontier for just $163, but on average you can expect to pay $224.

  • Are there nonstop flights from Des Moines to South Carolina for under $400 on Cheapflights?

    Cheapflights has at least 10 direct flights from Des Moines to South Carolina under $400. A good price for a nonstop flight from Des Moines to South Carolina is less than $503.

  • Are there last-minute flights available from Des Moines to South Carolina for under $400?

    There are currently 20+ open flights from Des Moines to South Carolina within the next 7 days for less than $400.

  • What are the cheapest airlines to fly from Des Moines to South Carolina one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $81. Users have also found prices from $98 and $239 on American Airlines and United Airlines, respectively.

  • What are the most popular routes from Des Moines to South Carolina?

    When deciding which route to take from Des Moines to South Carolina consider Des Moines - Myrtle Beach Intl, Des Moines - Charlotte Douglas or Des Moines - Charleston as they are the most popular.

  • What are the most popular airlines that fly from Des Moines to South Carolina?

    When booking a flight from Des Moines to South Carolina, you may want to consider flying on American Airlines, Delta or United Airlines as they are the most popular for this route.

  • What does DSM to CHS mean?

    This is defined as Des Moines Airport (DSM) and Charleston Airport (CHS). Codes like Charleston Airport are often used to just call airports uniquely. Myrtle Beach Intl Airport (MYR), Greenville Airport (GSP), Columbia Metropolitan Airport (CAE), Hilton Head Island Airport (HHH), Florence Airport (FLO) are other airports near this flight route and their unique identifiers/IATA codes.

  • Can I find deals for flights from Des Moines to South Carolina that include extra baggage allowance?

    The amount of baggage you can bring on your Des Moines to South Carolina flight depends on the airline and the type of fare you've chosen. After entering your flight details, you'll be able to view the specific baggage policies for each deal in the search results. Keep in mind that certain deals may offer additional baggage allowance.

  • Can I find deals on flights from Des Moines to South Carolina with specific airlines?

    Yes, Cheapflights allows you to browse and filter Des Moines to South Carolina flight deals by airline. After entering your origin and destination, use the available filters to view flights offered by airlines.

  • Can I find deals for flights from Des Moines to South Carolina that include hotel bookings?

    Yes. In addition to deals on Des Moines to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to South Carolina.

  • Can I find deals for business class flights from Des Moines to South Carolina?

    Yes. Cheapflights offers flight deals from Des Moines to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • Can I find deals for flights from Des Moines to South Carolina that allow pets onboard?

    Many airlines flying from Des Moines to South Carolina offer the option to travel with pets. After selecting a flight deal, you can find more information about the airline's pet policy on their official website or by contacting the airline directly. Please note that additional fees and restrictions may apply.

  • Can I find deals on last-minute flights from Des Moines to South Carolina?

    Yes, you can often find last-minute deals on Des Moines to South Carolina flights on Cheapflights. However, these deals can vary and may not always be available. We recommend checking back frequently or signing up for price alerts for the most up-to-date deals.

  • How recently were the Des Moines to South Carolina flight deals updated?

    The Des Moines to South Carolina flight deals you see on this page were last updated on 4/22.

See more FAQs

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Top 3 airlines flying from Des Moines to South Carolina

Discover the top 3 airlines that operate flights from Des Moines to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 3,086,534 searches. Data last updated April 23, 2024.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$194Average$392FlexibilityNo cancel feeOn-time71%
Search American Airlines flights
DeltaCheapest$234Average$361FlexibilityNo cancel feeOn-timeN/A
Search Delta flights
United AirlinesCheapest$277Average$413FlexibilityNo cancel feeOn-time69%
Search United Airlines flights
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Search flights from Des Moines to South Carolina by cabin class

Find flights from Des Moines to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
First Class
Business Class
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