$123+ Cheap flights from Des Moines (DSM) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/10. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Sep 9 — Sep 161
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Des Moines to South CarolinaExplore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 10, 2026.
Explore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 10, 2026.
This CheapOair deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1011:29 am -
1 stop6h 30m
Thu 9/177:54 pm -
1 stop24h 39m
Deal found 8/5![Frontier logo]()
$256
This CheapOair deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2411:29 am -
1 stop6h 30m
Sun 9/277:54 pm -
1 stop24h 39m
Deal found 8/5![Frontier logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:43 am -
2 stops22h 15m
Sun 10/258:35 am -
1 stop6h 24m
Deal found 8/6![Multiple Airlines logo]()
$284
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/53:20 pm -
1 stop5h 08m
Sat 9/125:38 pm -
1 stop6h 17m
Deal found 8/6![United Airlines logo]()
$295
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/85:42 pm -
1 stop13h 16m
Sun 10/118:35 am -
1 stop7h 07m
Deal found 8/6![Multiple Airlines logo]()
$298
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/46:40 am -
1 stop24h 15m
Wed 10/79:40 pm -
2 stops18h 02m
Deal found 8/6![Multiple Airlines logo]()
$300
This Delta deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:50 pm -
1 stop4h 03m
Sun 11/225:35 am -
1 stop6h 08m
Deal found 8/5![Delta logo]()
$307
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:10 am -
1 stop22h 45m
Wed 10/79:40 pm -
2 stops18h 02m
Deal found 8/6![Multiple Airlines logo]()
$307
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/101:58 pm -
2 stops27h 23m
Thu 9/1711:17 am -
1 stop9h 40m
Deal found 8/8![Multiple Airlines logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/131:58 pm -
2 stops28h 57m
Thu 9/1711:17 am -
1 stop9h 40m
Deal found 8/6![Multiple Airlines logo]()
$317
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/46:40 am -
1 stop9h 03m
Tue 10/138:11 pm -
2 stops36h 27m
Deal found 8/6![Multiple Airlines logo]()
$318
This Delta deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/205:45 am -
1 stop4h 27m
Sun 9/277:19 pm -
1 stop4h 07m
Deal found 8/5![Delta logo]()
$319
Best flights from Des Moines to South CarolinaDiscover carefully curated flight deals from Des Moines to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 10, 2026.
Discover carefully curated flight deals from Des Moines to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 10, 2026.
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:50 am -
1 stop4h 25m
Tue 10/61:30 pm -
1 stop9h 25m
Deal found 8/10![Southwest logo]()
$276
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:00 am -
2 stops7h 21m
Sat 9/125:38 pm -
1 stop6h 17m
Deal found 8/6![United Airlines logo]()
$300
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/28:10 am -
1 stop4h 21m
Wed 9/96:22 am -
1 stop6h 42m
Deal found 8/5![American Airlines logo]()
$327
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/277:30 am -
2 stops12h 56m
Wed 9/3012:23 pm -
1 stop21h 39m
Deal found 8/5![Multiple Airlines logo]()
$354
This Delta deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/235:30 am -
1 stop5h 17m
Thu 11/267:05 am -
1 stop4h 38m
Deal found 8/8![Delta logo]()
$371
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:00 am -
1 stop9h 30m
Sat 11/149:45 am -
2 stops10h 55m
Deal found 8/10![Southwest logo]()
$281
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/252:21 pm -
1 stop7h 31m
Tue 9/86:46 pm -
1 stop5h 58m
Deal found 8/9![American Airlines logo]()
$332
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/23:20 pm -
1 stop4h 59m
Sun 9/63:35 pm -
1 stop5h 49m
Deal found 8/6![United Airlines logo]()
$345
This Delta deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:00 am -
2 stops8h 27m
Wed 9/3012:17 pm -
2 stops9h 29m
Deal found 8/9![Delta logo]()
$374
This American Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/228:10 am -
1 stop4h 14m
Wed 8/269:59 am -
1 stop7h 28m
Deal found 8/7![American Airlines logo]()
$349
This United Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/23:20 pm -
1 stop4h 59m
Wed 9/96:45 am -
2 stops8h 35m
Deal found 8/5![United Airlines logo]()
$351
This Southwest deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:20 am -
2 stops11h 20m
Tue 11/31:30 pm -
2 stops9h 30m
Deal found 8/7![Southwest logo]()
$355
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:10 am -
2 stops9h 15m
Wed 9/91:10 pm -
2 stops8h 55m
Deal found 8/5![Southwest logo]()
$356
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/231:23 pm -
1 stop5h 17m
Mon 9/286:30 am -
1 stop5h 01m
Deal found 8/6![United Airlines logo]()
$365
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/136:00 am -
2 stops8h 32m
Sat 9/198:08 am -
1 stop4h 56m
Deal found 8/5![American Airlines logo]()
$377
This Southwest deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/215:40 am -
2 stops6h 30m
Mon 9/281:55 pm -
2 stops9h 20m
Deal found 8/7![Southwest logo]()
$357
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/143:11 pm -
1 stop5h 37m
Sat 10/173:38 pm -
1 stop6h 45m
Deal found 8/7![United Airlines logo]()
$365
This Delta deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:50 pm -
1 stop4h 09m
Thu 11/266:00 am -
1 stop5h 43m
Deal found 8/8![Delta logo]()
$442
This American Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:05 am -
2 stops8h 50m
Wed 10/77:00 am -
1 stop9h 11m
Deal found 8/7![American Airlines logo]()
$387
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/175:40 am -
1 stop4h 30m
Mon 9/216:30 pm -
1 stop4h 45m
Deal found 8/5![Southwest logo]()
$365
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/193:22 pm -
1 stop4h 51m
Sat 9/265:38 pm -
1 stop4h 45m
Deal found 8/6![United Airlines logo]()
$375
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/276:00 am -
1 stop6h 15m
Wed 9/306:22 am -
1 stop6h 42m
Deal found 8/5![American Airlines logo]()
$391
This Southwest deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/145:35 am -
1 stop4h 05m
Sat 10/1711:35 am -
2 stops10h 10m
Deal found 8/7![Southwest logo]()
$370
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am -
1 stop7h 30m
Wed 10/216:25 am -
2 stops8h 50m
Deal found 8/7![United Airlines logo]()
$383
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/77:05 am -
1 stop6h 20m
Sun 10/117:04 pm -
1 stop5h 54m
Deal found 8/5![American Airlines logo]()
$411
This Southwest deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:00 am -
2 stops10h 25m
Sat 11/1410:45 am -
2 stops10h 50m
Deal found 8/7![Southwest logo]()
$375
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:00 am -
2 stops8h 00m
Sat 10/173:00 pm -
2 stops7h 23m
Deal found 8/7![United Airlines logo]()
$384
This Southwest deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:40 am -
2 stops9h 45m
Thu 9/171:05 pm -
2 stops10h 10m
Deal found 8/8![Southwest logo]()
$375
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/281:30 pm -
1 stop4h 29m
Mon 10/58:31 pm -
1 stop4h 27m
Deal found 8/10![American Airlines logo]()
$417
This United Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:00 am -
2 stops7h 21m
Tue 9/810:22 am -
2 stops12h 06m
Deal found 8/9![United Airlines logo]()
$413
Last-minute flights from Des Moines to South CarolinaDiscover last-minute flight deals from Des Moines to South Carolina. Data last updated August 10, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to South Carolina. Data last updated August 10, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/252:21 pm -
1 stop7h 31m
Tue 9/86:46 pm -
1 stop5h 58m
Deal found 8/5![American Airlines logo]()
$322
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/28:10 am -
1 stop4h 21m
Wed 9/96:22 am -
1 stop6h 42m
Deal found 8/5![American Airlines logo]()
$327
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/53:20 pm -
1 stop5h 08m
Sat 9/125:38 pm -
1 stop6h 17m
Deal found 8/6![United Airlines logo]()
$295
This American Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/51:43 pm -
1 stop6h 43m
Fri 9/118:08 am -
1 stop4h 56m
Deal found 8/6![American Airlines logo]()
$325
This CheapOair deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1011:29 am -
1 stop6h 30m
Thu 9/177:54 pm -
1 stop24h 39m
Deal found 8/5![Frontier logo]()
$256
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/101:58 pm -
2 stops27h 23m
Thu 9/1711:17 am -
1 stop9h 40m
Deal found 8/8![Multiple Airlines logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/131:58 pm -
2 stops28h 57m
Thu 9/1711:17 am -
1 stop9h 40m
Deal found 8/6![Multiple Airlines logo]()
$317
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/131:58 pm -
2 stops27h 23m
Sat 9/195:37 pm -
1 stop27h 20m
Deal found 8/5![Multiple Airlines logo]()
$331
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/149:31 pm -
2 stops12h 45m
Thu 9/1711:17 am -
1 stop9h 40m
Deal found 8/6![Multiple Airlines logo]()
$323
This Delta deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/205:45 am -
1 stop4h 27m
Sun 9/277:19 pm -
1 stop4h 07m
Deal found 8/5![Delta logo]()
$319
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2010:35 am -
1 stop7h 36m
Tue 9/294:46 pm -
1 stop7h 26m
Deal found 8/5![American Airlines logo]()
$327
This CheapOair deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2411:29 am -
1 stop6h 30m
Sun 9/277:54 pm -
1 stop24h 39m
Deal found 8/5![Frontier logo]()
$264
One-way flights from Des Moines to South CarolinaSearch for one-way flight options from Des Moines to South Carolina. Find affordable one-way fares based on user searches. Data last updated August 10, 2026.
Search for one-way flight options from Des Moines to South Carolina. Find affordable one-way fares based on user searches. Data last updated August 10, 2026.
This Frontier deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1011:29 am -
1 stop6h 30m
Deal found 8/7![Frontier logo]()
$123
This Frontier deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/411:29 am -
1 stop6h 30m
Deal found 8/7![Frontier logo]()
$131
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:10 am -
1 stop4h 45m
Deal found 8/10![Southwest logo]()
$137
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:07 pm -
1 stop23h 07m
Deal found 8/8![Multiple Airlines logo]()
$139
This CheapOair deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/62:51 pm -
1 stop26h 55m
Deal found 8/7![Frontier logo]()
$142
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/113:54 pm -
1 stop27h 01m
Deal found 8/10![Multiple Airlines logo]()
$150
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/61:58 pm -
2 stops17h 03m
Deal found 8/6![Multiple Airlines logo]()
$155
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/101:58 pm -
2 stops27h 23m
Deal found 8/9![Multiple Airlines logo]()
$159
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/46:40 am -
2 stops24h 55m
Deal found 8/6![Multiple Airlines logo]()
$160
This CheapOair deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/42:19 pm -
1 stop25h 07m
Deal found 8/5![Frontier logo]()
$161
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/138:00 am -
1 stop5h 25m
Deal found 8/7![United Airlines logo]()
$183
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/812:25 pm -
1 stop18h 33m
Deal found 8/6![Multiple Airlines logo]()
$188
Find flight deals from Des Moines to South Carolina
Keep the following information in mind while searching for Des Moines to South Carolina flight deals. Data was last updated August 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $256 (CheapOair) |
One-way from | $123 (Frontier) |
Popular in | July |
Cheapest in | January |
Average price | $397 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 10, 2026.
Use the filters below to find and compare flights from Des Moines to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSavannah
DSM Des Moines - SAV Savannah/Hilton Head
DSMSAV
Des Moines
Sat 10/3
5:50 am-11:15 am
1 stop4h 25m
Savannah/Hilton Head
Tue 10/6
1:30 pm-9:55 pm
1 stop9h 25m
$276
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Tue 11/10
6:00 am-4:30 pm
1 stop9h 30m
Charleston
Sat 11/14
9:45 am-7:40 pm
2 stops10h 55m
$281
Des MoinesColumbia
DSM Des Moines - CAE Columbia Metropolitan
DSMCAE
Des Moines
Sat 9/5
6:00 am-2:21 pm
2 stops7h 21m
Columbia Metropolitan
Sat 9/12
5:38 pm-10:55 pm
1 stop6h 17m
$300
Des MoinesSavannah
DSM Des Moines - SAV Savannah/Hilton Head
DSMSAV
Des Moines
Wed 9/2
8:10 am-1:31 pm
1 stop4h 21m
Savannah/Hilton Head
Wed 9/9
6:22 am-12:04 pm
1 stop6h 42m
$327
Des MoinesColumbia
DSM Des Moines - CAE Columbia Metropolitan
DSMCAE
Des Moines
Tue 8/25
2:21 pm-10:52 pm
1 stop7h 31m
Columbia Metropolitan
Tue 9/8
6:46 pm-11:44 pm
1 stop5h 58m
$332
Des MoinesSavannah
DSM Des Moines - SAV Savannah/Hilton Head
DSMSAV
Des Moines
Wed 9/2
3:20 pm-9:19 pm
1 stop4h 59m
Savannah/Hilton Head
Sun 9/6
3:35 pm-8:24 pm
1 stop5h 49m
$345
Des MoinesColumbia
DSM Des Moines - CAE Columbia Metropolitan
DSMCAE
Des Moines
Sat 8/22
8:10 am-1:24 pm
1 stop4h 14m
Columbia Metropolitan
Wed 8/26
9:59 am-4:27 pm
1 stop7h 28m
$349
Des MoinesSavannah
DSM Des Moines - SAV Savannah/Hilton Head
DSMSAV
Des Moines
Wed 9/2
3:20 pm-9:19 pm
1 stop4h 59m
Savannah/Hilton Head
Wed 9/9
6:45 am-2:20 pm
2 stops8h 35m
$351
Des MoinesSavannah
DSM Des Moines - SAV Savannah/Hilton Head
DSMSAV
Des Moines
Sun 9/27
7:30 am-9:26 pm
2 stops12h 56m
Savannah/Hilton Head
Wed 9/30
12:23 pm-9:02 am
1 stop21h 39m
$354
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Fri 10/30
6:20 am-6:40 pm
2 stops11h 20m
Charleston
Tue 11/3
1:30 pm-10:00 pm
2 stops9h 30m
$355
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Des Moines to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Des Moines with our price prediction graph.
DSM-SAV
DSM-CAE
DSM-CHS
DSM-HHH
DSM-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to South Carolina
DSM-USSC
DSM-SAV
DSM-CAE
DSM-CHS
DSM-HHH
What is the cheapest month to book a flight from Des Moines to South Carolina?
Currently, September is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $357). Flying from Des Moines to South Carolina in March is currently the most expensive (average of $473). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to South Carolina?
Airfare is below average for this route at the moment.
Des Moines to South Carolina flights typically cost between $387 and $438 in November.The cheapest round-trip price found within the last 5 days was $269 on Delta (Nov 10-Nov 14).
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated August 10, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Des Moines to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.0
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Overall
8.0
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Overall
8.0
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Overall
8.0
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Overall
8.0
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Des Moines to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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Des Moines and South Carolina flights
Browse other Des Moines and South Carolina flight options. Last updated on August 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Des Moines to South Carolina flights
Consider these flights traveling from Des Moines to South Carolina.
Top 4 airlines flying from Des Moines to South Carolina
Discover the top 4 airlines that operate flights from Des Moines to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$158 | Average$425 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$266 | Average$433 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$281 | Average$425 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$344 | Average$412 | FlexibilityNo cancel fee | On-time63% |