$100+ Cheap flights from Des Moines (DSM) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/7. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
May 14 — May 211
Round-trip
1 adult, Economy
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Cheapest flights from Des Moines to South CarolinaExplore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 14, 2026.
Explore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 14, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/32:36 pm
DSM
- CLT
1 stop22h 42m
Multiple Airlines
Wed 5/63:16 pm
CLT
- DSM
1 stop24h 59m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/244:41 pm
DSM
- CLT
1 stop16h 22m
Multiple Airlines
Sun 5/3112:58 pm
CLT
- DSM
1 stop10h 33m
Multiple Airlines
Deal found 4/10![Multiple Airlines logo]()
$216
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/43:37 pm
DSM
- CLT
1 stop19h 26m
Multiple Airlines
Sun 6/710:58 am
CLT
- DSM
1 stop12h 54m
Multiple Airlines
Deal found 4/10![Multiple Airlines logo]()
$221
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/302:36 pm
DSM
- CLT
1 stop17h 34m
Multiple Airlines
Wed 5/63:16 pm
CLT
- DSM
1 stop24h 59m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$223
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
- CLT
1 stop18h 22m
Multiple Airlines
Thu 6/41:00 pm
CLT
- DSM
1 stop9h 27m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$229
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:33 pm
DSM
- CLT
2 stops18h 38m
Multiple Airlines
Wed 5/63:16 pm
CLT
- DSM
1 stop24h 59m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/43:37 pm
DSM
- CLT
1 stop25h 09m
Multiple Airlines
Wed 6/103:16 pm
CLT
- DSM
2 stops31h 11m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$238
This Kiwi.com deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
- CLT
1 stop27h 02m
Multiple Airlines
Sat 6/66:00 am
CLT
- DSM
2 stops41h 52m
Multiple Airlines
Deal found 4/11![Multiple Airlines logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:23 pm
DSM
- CLT
2 stops21h 50m
Multiple Airlines
Thu 5/76:00 am
CLT
- DSM
1 stop10h 15m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
- CLT
1 stop16h 22m
Multiple Airlines
Sat 6/66:00 am
CLT
- DSM
2 stops41h 52m
Multiple Airlines
Deal found 4/11![Multiple Airlines logo]()
$255
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/211:00 am
DSM
- GSP
1 stop21h 28m
Allegiant Air
Thu 5/79:33 am
GSP
- DSM
2 stops38h 24m
Allegiant Air
Deal found 4/9![Allegiant Air logo]()
$278
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/32:36 pm
DSM
- GSP
1 stop25h 17m
Allegiant Air
Thu 5/79:33 am
GSP
- DSM
2 stops38h 24m
Allegiant Air
Deal found 4/9![Allegiant Air logo]()
$290
Best flights from Des Moines to South CarolinaDiscover carefully curated flight deals from Des Moines to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 14, 2026.
Discover carefully curated flight deals from Des Moines to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 14, 2026.
This United Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/188:00 am
DSM
- SAV
1 stop5h 11m
United Airlines
Tue 8/187:05 pm
SAV
- DSM
1 stop6h 29m
United Airlines
Deal found 4/9![United Airlines logo]()
$330
This Delta deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/226:41 pm
DSM
- CAE
1 stop4h 08m
Delta
Sat 5/235:40 am
CAE
- DSM
1 stop6h 28m
Delta
Deal found 4/10![Delta logo]()
$332
This Southwest deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/125:10 am
DSM
- CHS
1 stop5h 15m
Southwest
Wed 6/177:00 am
CHS
- DSM
1 stop5h 30m
Southwest
Deal found 4/11![Southwest logo]()
$371
This American Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/237:11 am
DSM
- CAE
1 stop8h 40m
American Airlines
Sat 5/96:00 am
CAE
- DSM
1 stop8h 20m
American Airlines
Deal found 4/10![American Airlines logo]()
$371
This Delta deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/145:27 am
DSM
- CAE
1 stop6h 47m
Delta
Sat 5/166:40 am
CAE
- DSM
1 stop5h 28m
Delta
Deal found 4/10![Delta logo]()
$332
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:00 am
DSM
- SAV
1 stop7h 16m
United Airlines
Tue 6/96:36 pm
SAV
- DSM
1 stop5h 40m
United Airlines
Deal found 4/13![United Airlines logo]()
$335
This Delta deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/96:39 pm
DSM
- MYR
1 stop4h 20m
Delta
Tue 6/161:51 pm
MYR
- DSM
1 stop5h 03m
Delta
Deal found 4/8![Delta logo]()
$335
This United Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2511:25 am
DSM
- CAE
1 stop4h 30m
United Airlines
Wed 4/295:35 pm
CAE
- DSM
1 stop6h 42m
United Airlines
Deal found 4/10![United Airlines logo]()
$339
This Southwest deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:40 am
DSM
- CHS
2 stops10h 25m
Southwest
Sat 5/98:00 am
CHS
- DSM
2 stops13h 55m
Southwest
Deal found 4/10![Southwest logo]()
$373
This American Airlines deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/411:09 am
DSM
- GSP
1 stop7h 37m
American Airlines
Thu 5/712:35 pm
GSP
- DSM
1 stop8h 46m
American Airlines
Deal found 4/11![American Airlines logo]()
$375
This Delta deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/135:27 am
DSM
- MYR
1 stop6h 13m
Delta
Sat 5/166:00 am
MYR
- DSM
1 stop6h 08m
Delta
Deal found 4/8![Delta logo]()
$336
This United Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:15 am
DSM
- CHS
1 stop5h 02m
United Airlines
Wed 9/210:00 am
CHS
- DSM
2 stops8h 02m
United Airlines
Deal found 4/9![United Airlines logo]()
$340
This Southwest deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:55 am
DSM
- CHS
2 stops10h 40m
Southwest
Sat 5/167:35 am
CHS
- DSM
2 stops14h 20m
Southwest
Deal found 4/13![Southwest logo]()
$375
This American Airlines deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/132:24 pm
DSM
- SAV
2 stops8h 29m
American Airlines
Sun 5/175:00 am
SAV
- DSM
2 stops6h 31m
American Airlines
Deal found 4/11![American Airlines logo]()
$381
This Delta deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:31 pm
DSM
- MYR
1 stop4h 43m
Delta
Sat 5/94:54 pm
MYR
- DSM
1 stop4h 28m
Delta
Deal found 4/11![Delta logo]()
$337
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1210:02 am
DSM
- CHS
2 stops7h 57m
United Airlines
Sat 5/165:07 pm
CHS
- DSM
1 stop6h 38m
United Airlines
Deal found 4/13![United Airlines logo]()
$351
This Southwest deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/203:15 pm
DSM
- CLT
1 stop4h 40m
Southwest
Thu 5/217:30 am
CLT
- DSM
1 stop5h 15m
Southwest
Deal found 4/13![Southwest logo]()
$387
This American Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:00 am
DSM
- HHH
1 stop8h 14m
American Airlines
Mon 4/275:04 pm
HHH
- DSM
1 stop6h 14m
American Airlines
Deal found 4/9![American Airlines logo]()
$389
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/226:41 pm
DSM
- CAE
1 stop4h 08m
Delta
Mon 5/257:17 pm
CAE
- DSM
1 stop4h 15m
Delta
Deal found 4/13![Delta logo]()
$347
This American Airlines deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/256:55 am
DSM
- GSP
1 stop6h 12m
American Airlines
Mon 6/15:25 pm
GSP
- DSM
1 stop7h 32m
American Airlines
Deal found 4/11![American Airlines logo]()
$391
This Southwest deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/85:25 am
DSM
- MYR
2 stops8h 45m
Southwest
Tue 5/122:10 pm
MYR
- DSM
2 stops9h 00m
Southwest
Deal found 4/11![Southwest logo]()
$391
This United Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/306:00 am
DSM
- HHH
1 stop7h 21m
United Airlines
Tue 7/73:05 pm
HHH
- DSM
1 stop7h 35m
United Airlines
Deal found 4/8![United Airlines logo]()
$359
This Delta deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/105:27 am
DSM
- CAE
1 stop6h 47m
Delta
Sun 5/175:38 am
CAE
- DSM
1 stop6h 30m
Delta
Deal found 4/12![Delta logo]()
$354
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/225:00 am
DSM
- HHH
2 stops8h 26m
American Airlines
Sat 4/252:10 pm
HHH
- DSM
1 stop8h 44m
American Airlines
Deal found 4/8![American Airlines logo]()
$394
This United Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/241:10 pm
DSM
- CAE
1 stop7h 11m
United Airlines
Tue 4/286:30 am
CAE
- DSM
1 stop5h 14m
United Airlines
Deal found 4/8![United Airlines logo]()
$359
This Southwest deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/14:20 pm
DSM
- CHS
1 stop4h 35m
Southwest
Sat 5/27:35 am
CHS
- DSM
2 stops14h 20m
Southwest
Deal found 4/9![Southwest logo]()
$397
This Delta deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/47:28 am
DSM
- GSP
1 stop6h 46m
Delta
Tue 5/55:50 pm
GSP
- DSM
1 stop5h 44m
Delta
Deal found 4/9![Delta logo]()
$355
This American Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/97:10 am
DSM
- CAE
1 stop7h 15m
American Airlines
Sun 6/148:30 pm
CAE
- DSM
1 stop4h 40m
American Airlines
Deal found 4/13![American Airlines logo]()
$398
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/124:15 pm
DSM
- CHS
1 stop5h 35m
Southwest
Thu 7/165:55 pm
CHS
- DSM
1 stop6h 35m
Southwest
Deal found 4/8![Southwest logo]()
$407
This United Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:15 am
DSM
- SAV
2 stops7h 30m
United Airlines
Mon 5/43:35 pm
SAV
- DSM
1 stop8h 10m
United Airlines
Deal found 4/8![United Airlines logo]()
$371
Last-minute flights from Des Moines to South CarolinaDiscover last-minute flight deals from Des Moines to South Carolina. Data last updated April 14, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to South Carolina. Data last updated April 14, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/302:36 pm
DSM
- CLT
1 stop17h 34m
Multiple Airlines
Wed 5/63:16 pm
CLT
- DSM
1 stop24h 59m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$223
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/302:36 pm
DSM
- CLT
1 stop17h 34m
Multiple Airlines
Thu 5/79:07 pm
CLT
- DSM
2 stops26h 50m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/211:00 am
DSM
- GSP
1 stop21h 28m
Allegiant Air
Thu 5/79:33 am
GSP
- DSM
2 stops38h 24m
Allegiant Air
Deal found 4/9![Allegiant Air logo]()
$278
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/32:36 pm
DSM
- CLT
1 stop22h 42m
Multiple Airlines
Wed 5/63:16 pm
CLT
- DSM
1 stop24h 59m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/32:36 pm
DSM
- GSP
1 stop25h 17m
Allegiant Air
Thu 5/79:33 am
GSP
- DSM
2 stops38h 24m
Allegiant Air
Deal found 4/9![Allegiant Air logo]()
$290
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:33 pm
DSM
- CLT
2 stops18h 38m
Multiple Airlines
Wed 5/63:16 pm
CLT
- DSM
1 stop24h 59m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:23 pm
DSM
- CLT
2 stops21h 50m
Multiple Airlines
Thu 5/76:00 am
CLT
- DSM
1 stop10h 15m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$254
This American Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/147:11 am
DSM
- CAE
1 stop8h 40m
American Airlines
Sat 5/165:00 am
CAE
- DSM
2 stops6h 31m
American Airlines
Deal found 4/10![American Airlines logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/244:41 pm
DSM
- CLT
1 stop16h 22m
Multiple Airlines
Sun 5/3112:58 pm
CLT
- DSM
1 stop10h 33m
Multiple Airlines
Deal found 4/10![Multiple Airlines logo]()
$216
This Kiwi.com deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
- CLT
1 stop27h 02m
Multiple Airlines
Sat 6/66:00 am
CLT
- DSM
2 stops41h 52m
Multiple Airlines
Deal found 4/11![Multiple Airlines logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
- CLT
1 stop18h 22m
Multiple Airlines
Thu 6/41:00 pm
CLT
- DSM
1 stop9h 27m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$229
This Kiwi.com deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
- CLT
1 stop16h 22m
Multiple Airlines
Sat 6/66:00 am
CLT
- DSM
2 stops41h 52m
Multiple Airlines
Deal found 4/11![Multiple Airlines logo]()
$255
One-way flights from Des Moines to South CarolinaSearch for one-way flight options from Des Moines to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 14, 2026.
Search for one-way flight options from Des Moines to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 14, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/75:02 pm
DSM
- CLT
1 stop23h 44m
Multiple Airlines
Deal found 4/11![Multiple Airlines logo]()
$100
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/107:45 am
DSM
- CLT
1 stop11h 17m
Multiple Airlines
Deal found 4/10![Multiple Airlines logo]()
$101
This CheapOair deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/242:04 pm
DSM
- CLT
1 stop25h 52m
Frontier
Deal found 4/10![Frontier logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/32:36 pm
DSM
- CLT
1 stop22h 42m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$106
This CheapOair deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/102:16 pm
DSM
- CLT
1 stop27h 03m
Frontier
Deal found 4/11![Frontier logo]()
$107
This Kiwi.com deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/84:07 pm
DSM
- CLT
1 stop21h 04m
Multiple Airlines
Deal found 4/11![Multiple Airlines logo]()
$108
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/124:57 pm
DSM
- CLT
1 stop16h 00m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/134:40 pm
DSM
- CHS
1 stop24h 34m
Multiple Airlines
Deal found 4/12![Multiple Airlines logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/64:40 pm
DSM
- CHS
1 stop24h 34m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$148
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/284:01 pm
DSM
- SAV
2 stops28h 45m
Allegiant Air
Deal found 4/9![Allegiant Air logo]()
$152
This Delta deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:41 pm
DSM
- CHS
1 stop4h 18m
Delta
Deal found 4/9![Delta logo]()
$168
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:30 pm
DSM
- MYR
1 stop4h 09m
Delta
Deal found 4/13![Delta logo]()
$168
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 14, 2026.
Use the filters below to find and compare flights from Des Moines to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSavannah
DSM - SAV
DSMSAV
Des Moines
Tue 8/18
8:00 am-2:11 pm
1 stop5h 11m
Savannah/Hilton Head
Tue 8/18
7:05 pm-12:34 am
1 stop6h 29m
$330
Des MoinesColumbia
DSM - CAE
DSMCAE
Des Moines
Fri 5/22
6:41 pm-11:49 pm
1 stop4h 08m
Columbia Metropolitan
Sat 5/23
5:40 am-11:08 am
1 stop6h 28m
$332
Des MoinesColumbia
DSM - CAE
DSMCAE
Des Moines
Thu 5/14
5:27 am-1:14 pm
1 stop6h 47m
Columbia Metropolitan
Sat 5/16
6:40 am-11:08 am
1 stop5h 28m
$332
Des MoinesSavannah
DSM - SAV
DSMSAV
Des Moines
Wed 5/27
6:00 am-2:16 pm
1 stop7h 16m
Savannah/Hilton Head
Tue 6/9
6:36 pm-11:16 pm
1 stop5h 40m
$335
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Tue 6/9
6:39 pm-11:59 pm
1 stop4h 20m
Myrtle Beach Intl
Tue 6/16
1:51 pm-5:54 pm
1 stop5h 03m
$335
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Wed 5/13
5:27 am-12:40 pm
1 stop6h 13m
Myrtle Beach Intl
Sat 5/16
6:00 am-11:08 am
1 stop6h 08m
$336
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Sat 5/2
6:31 pm-12:14 am
1 stop4h 43m
Myrtle Beach Intl
Sat 5/9
4:54 pm-8:22 pm
1 stop4h 28m
$337
Des MoinesColumbia
DSM - CAE
DSMCAE
Des Moines
Sat 4/25
11:25 am-4:55 pm
1 stop4h 30m
Columbia Metropolitan
Wed 4/29
5:35 pm-11:17 pm
1 stop6h 42m
$339
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Wed 5/20
6:15 am-12:17 pm
1 stop5h 02m
Charleston
Wed 9/2
10:00 am-5:02 pm
2 stops8h 02m
$340
Quickest round-trip
Des MoinesColumbia
DSM - CAE
DSMCAE
Des Moines
Fri 5/22
6:41 pm-11:49 pm
1 stop4h 08m
Columbia Metropolitan
Mon 5/25
7:17 pm-10:32 pm
1 stop4h 15m
$347
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Des Moines to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Des Moines with our price prediction graph.
DSM-SAV
DSM-CHS
DSM-CLT
DSM-GSP
DSM-HHH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to South Carolina
DSM-USSC
DSM-SAV
DSM-CHS
DSM-CLT
DSM-GSP
What is the cheapest month to book a flight from Des Moines to South Carolina?
Currently, September is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $204). Flying from Des Moines to South Carolina in March is currently the most expensive (average of $343). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to South Carolina?
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 14, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Des Moines to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Des Moines to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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Des Moines and South Carolina flights
Browse other Des Moines and South Carolina flight options. Last updated on April 14, 2026.
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Des Moines to South Carolina flights
Consider these flights traveling from Des Moines to South Carolina.
Top 4 airlines flying from Des Moines to South Carolina
Discover the top 4 airlines that operate flights from Des Moines to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 14, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$237 | Average$414 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$242 | Average$368 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$266 | Average$512 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$272 | Average$397 | FlexibilityNo cancel fee | On-time63% |