$143+ Cheap flights from Des Moines (DSM) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/17. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Aug 20 — Aug 271
Round-trip
1 adult, Economy
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Cheapest flights from Des Moines to South CarolinaExplore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 21, 2026.
Explore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 21, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:10 am
DSM
- MYR
2 stops26h 34m
Multiple Airlines
Thu 10/88:35 am
MYR
- DSM
1 stop7h 07m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$253
This Kiwi.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/315:28 pm
DSM
- CHS
1 stop14h 10m
Multiple Airlines
Fri 9/43:54 pm
CHS
- DSM
1 stop7h 14m
Multiple Airlines
Deal found 7/20![Multiple Airlines logo]()
$268
This Kiwi.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/108:00 am
DSM
- GSP
2 stops10h 49m
Multiple Airlines
Thu 9/177:59 pm
GSP
- DSM
1 stop27h 09m
Multiple Airlines
Deal found 7/20![Multiple Airlines logo]()
$278
This Kiwi.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3012:45 pm
DSM
- GSP
1 stop18h 04m
Multiple Airlines
Wed 10/78:24 pm
GSP
- DSM
2 stops21h 28m
Multiple Airlines
Deal found 7/20![Multiple Airlines logo]()
$280
This American Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/51:43 pm
DSM
- CAE
1 stop5h 26m
American Airlines
Fri 9/116:47 pm
CAE
- DSM
1 stop5h 54m
American Airlines
Deal found 7/19![American Airlines logo]()
$285
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/1410:24 am
DSM
- GSP
1 stop7h 41m
Multiple Airlines
Thu 9/177:59 pm
GSP
- DSM
1 stop27h 09m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$293
This Kiwi.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3012:45 pm
DSM
- GSP
1 stop18h 04m
Allegiant Air
Mon 10/53:19 pm
GSP
- DSM
1 stop6h 23m
Allegiant Air
Deal found 7/20![Allegiant Air logo]()
$297
This American Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1210:26 am
DSM
- CAE
1 stop5h 09m
American Airlines
Tue 8/186:46 pm
CAE
- DSM
1 stop5h 58m
American Airlines
Deal found 7/17![American Airlines logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3012:45 pm
DSM
- GSP
1 stop18h 04m
Multiple Airlines
Tue 10/611:28 am
GSP
- DSM
2 stops52h 14m
Multiple Airlines
Deal found 7/20![Multiple Airlines logo]()
$300
This United Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:00 am
DSM
- CAE
2 stops7h 21m
United Airlines
Tue 8/186:25 am
CAE
- DSM
1 stop6h 55m
United Airlines
Deal found 7/17![United Airlines logo]()
$302
This Kiwi.com deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/285:29 pm
DSM
- CHS
1 stop18h 02m
Multiple Airlines
Sat 10/33:42 pm
CHS
- DSM
2 stops21h 57m
Multiple Airlines
Deal found 7/17![Multiple Airlines logo]()
$307
This Delta deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:35 pm
DSM
- CAE
1 stop4h 19m
Delta
Mon 8/176:08 pm
CAE
- DSM
1 stop5h 29m
Delta
Deal found 7/20![Delta logo]()
$309
Best flights from Des Moines to South CarolinaDiscover carefully curated flight deals from Des Moines to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 21, 2026.
Discover carefully curated flight deals from Des Moines to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 21, 2026.
This American Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/101:30 pm
DSM
- CAE
1 stop4h 38m
American Airlines
Sat 9/125:21 pm
CAE
- DSM
1 stop6h 51m
American Airlines
Deal found 7/19![American Airlines logo]()
$285
This United Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:00 am
DSM
- CAE
2 stops7h 21m
United Airlines
Tue 8/186:25 am
CAE
- DSM
1 stop6h 55m
United Airlines
Deal found 7/17![United Airlines logo]()
$302
This Southwest deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/205:40 am
DSM
- MYR
2 stops12h 40m
Southwest
Mon 8/242:00 pm
MYR
- DSM
2 stops9h 10m
Southwest
Deal found 7/16![Southwest logo]()
$333
This Delta deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/711:27 am
DSM
- CHS
1 stop4h 47m
Delta
Tue 11/106:30 am
CHS
- DSM
1 stop4h 48m
Delta
Deal found 7/19![Delta logo]()
$355
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:45 am
DSM
- SAV
1 stop8h 24m
United Airlines
Mon 8/248:10 am
SAV
- DSM
1 stop7h 06m
United Airlines
Deal found 7/21![United Airlines logo]()
$317
This American Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/308:03 am
DSM
- HHH
1 stop4h 42m
American Airlines
Sat 10/32:20 pm
HHH
- DSM
1 stop6h 28m
American Airlines
Deal found 7/20![American Airlines logo]()
$319
This Southwest deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:50 am
DSM
- MYR
2 stops10h 25m
Southwest
Sat 10/2411:40 am
MYR
- DSM
2 stops10h 05m
Southwest
Deal found 7/18![Southwest logo]()
$347
This Delta deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/222:34 pm
DSM
- GSP
1 stop5h 03m
Delta
Tue 9/297:00 am
GSP
- DSM
1 stop4h 46m
Delta
Deal found 7/20![Delta logo]()
$355
This United Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/21:21 pm
DSM
- CHS
1 stop7h 13m
United Airlines
Mon 9/76:30 am
CHS
- DSM
1 stop4h 56m
United Airlines
Deal found 7/20![United Airlines logo]()
$335
This American Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/51:08 pm
DSM
- CAE
1 stop6h 48m
American Airlines
Sun 8/98:34 pm
CAE
- DSM
1 stop4h 14m
American Airlines
Deal found 7/21![American Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2210:20 am
DSM
- GSP
1 stop6h 57m
Delta
Wed 9/302:00 pm
GSP
- DSM
1 stop5h 09m
Delta
Deal found 7/18![Delta logo]()
$355
This Southwest deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/182:40 pm
DSM
- CLT
1 stop5h 30m
Southwest
Tue 8/256:35 pm
CLT
- DSM
1 stop4h 20m
Southwest
Deal found 7/19![Southwest logo]()
$355
This United Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/23:20 pm
DSM
- SAV
1 stop4h 59m
United Airlines
Sun 9/66:00 am
SAV
- DSM
2 stops9h 16m
United Airlines
Deal found 7/20![United Airlines logo]()
$341
This Southwest deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:10 am
DSM
- SAV
2 stops9h 15m
Southwest
Mon 8/176:20 pm
SAV
- DSM
1 stop4h 50m
Southwest
Deal found 7/17![Southwest logo]()
$360
This Delta deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/236:55 am
DSM
- CHS
1 stop6h 22m
Delta
Mon 8/245:10 am
CHS
- DSM
1 stop6h 33m
Delta
Deal found 7/16![Delta logo]()
$362
This American Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/162:08 pm
DSM
- GSP
1 stop4h 15m
American Airlines
Fri 1/17:37 am
GSP
- DSM
1 stop5h 49m
American Airlines
Deal found 7/16![American Airlines logo]()
$362
This United Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:00 am
DSM
- CAE
2 stops7h 21m
United Airlines
Mon 8/1710:22 am
CAE
- DSM
2 stops12h 01m
United Airlines
Deal found 7/20![United Airlines logo]()
$352
This Southwest deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:10 am
DSM
- SAV
1 stop10h 30m
Southwest
Sat 8/157:40 am
SAV
- DSM
1 stop4h 50m
Southwest
Deal found 7/18![Southwest logo]()
$361
This American Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/111:09 pm
DSM
- MYR
2 stops8h 44m
American Airlines
Mon 9/147:19 pm
MYR
- DSM
1 stop5h 22m
American Airlines
Deal found 7/20![American Airlines logo]()
$372
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:00 am
DSM
- CAE
2 stops7h 21m
United Airlines
Mon 8/242:56 pm
CAE
- DSM
2 stops7h 27m
United Airlines
Deal found 7/21![United Airlines logo]()
$353
This Delta deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:54 pm
DSM
- CHS
1 stop4h 05m
Delta
Fri 10/93:20 pm
CHS
- DSM
1 stop4h 51m
Delta
Deal found 7/20![Delta logo]()
$391
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/45:30 am
DSM
- SAV
1 stop5h 05m
Southwest
Sat 10/104:45 pm
SAV
- DSM
1 stop5h 00m
Southwest
Deal found 7/20![Southwest logo]()
$362
This American Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:00 am
DSM
- MYR
2 stops9h 55m
American Airlines
Wed 10/75:00 am
MYR
- DSM
1 stop6h 42m
American Airlines
Deal found 7/21![American Airlines logo]()
$377
This United Airlines deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/143:15 pm
DSM
- CHS
1 stop4h 49m
United Airlines
Tue 1/192:30 pm
CHS
- DSM
2 stops9h 31m
United Airlines
Deal found 7/18![United Airlines logo]()
$360
This Southwest deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:40 am
DSM
- SAV
2 stops8h 55m
Southwest
Thu 9/106:20 pm
SAV
- DSM
1 stop4h 50m
Southwest
Deal found 7/17![Southwest logo]()
$367
This Delta deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/245:45 am
DSM
- GSP
1 stop6h 05m
Delta
Fri 10/26:25 pm
GSP
- DSM
1 stop5h 01m
Delta
Deal found 7/18![Delta logo]()
$407
This American Airlines deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/136:00 am
DSM
- MYR
2 stops8h 32m
American Airlines
Sat 9/198:08 am
MYR
- DSM
1 stop4h 56m
American Airlines
Deal found 7/18![American Airlines logo]()
$377
This United Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/231:35 pm
DSM
- CHS
1 stop7h 00m
United Airlines
Mon 8/244:38 pm
CHS
- DSM
1 stop5h 45m
United Airlines
Deal found 7/16![United Airlines logo]()
$362
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:00 am
DSM
- CHS
2 stops10h 05m
Southwest
Sun 12/65:30 am
CHS
- DSM
2 stops8h 40m
Southwest
Deal found 7/20![Southwest logo]()
$372
This Delta deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:00 am
DSM
- HHH
2 stops8h 32m
Delta
Mon 8/2412:15 pm
HHH
- DSM
1 stop6h 35m
Delta
Deal found 7/20![Delta logo]()
$418
Last-minute flights from Des Moines to South CarolinaDiscover last-minute flight deals from Des Moines to South Carolina. Data last updated July 21, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to South Carolina. Data last updated July 21, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/315:12 am
DSM
- CAE
1 stop7h 11m
American Airlines
Thu 8/66:46 pm
CAE
- DSM
1 stop5h 58m
American Airlines
Deal found 7/16![American Airlines logo]()
$324
This American Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1210:26 am
DSM
- CAE
1 stop5h 09m
American Airlines
Tue 8/186:46 pm
CAE
- DSM
1 stop5h 58m
American Airlines
Deal found 7/17![American Airlines logo]()
$297
This United Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:00 am
DSM
- CAE
2 stops7h 21m
United Airlines
Tue 8/186:25 am
CAE
- DSM
1 stop6h 55m
United Airlines
Deal found 7/17![United Airlines logo]()
$302
This Delta deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:35 pm
DSM
- CAE
1 stop4h 19m
Delta
Mon 8/176:08 pm
CAE
- DSM
1 stop5h 29m
Delta
Deal found 7/20![Delta logo]()
$309
This United Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/133:20 pm
DSM
- CHS
1 stop5h 14m
United Airlines
Sat 8/156:30 am
CHS
- DSM
1 stop4h 56m
United Airlines
Deal found 7/20![United Airlines logo]()
$317
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/133:50 pm
DSM
- CLT
1 stop5h 00m
Southwest
Mon 8/176:30 pm
CLT
- DSM
1 stop4h 40m
Southwest
Deal found 7/20![Southwest logo]()
$321
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:40 am
DSM
- CHS
2 stops8h 45m
Southwest
Sat 8/157:35 am
CHS
- DSM
1 stop4h 55m
Southwest
Deal found 7/20![Southwest logo]()
$322
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:45 am
DSM
- SAV
1 stop8h 24m
United Airlines
Mon 8/248:10 am
SAV
- DSM
1 stop7h 06m
United Airlines
Deal found 7/21![United Airlines logo]()
$317
This American Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/188:10 am
DSM
- HHH
1 stop5h 47m
American Airlines
Mon 8/241:52 pm
HHH
- DSM
1 stop6h 27m
American Airlines
Deal found 7/20![American Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/201:08 pm
DSM
- MYR
1 stop6h 51m
American Airlines
Mon 8/246:04 pm
MYR
- DSM
1 stop6h 40m
American Airlines
Deal found 7/16![American Airlines logo]()
$317
This Southwest deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/205:40 am
DSM
- CLT
1 stop4h 30m
Southwest
Thu 8/201:05 pm
CLT
- DSM
2 stops10h 05m
Southwest
Deal found 7/21![Southwest logo]()
$326
This Kiwi.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/315:28 pm
DSM
- CHS
1 stop14h 10m
Multiple Airlines
Fri 9/43:54 pm
CHS
- DSM
1 stop7h 14m
Multiple Airlines
Deal found 7/20![Multiple Airlines logo]()
$268
One-way flights from Des Moines to South CarolinaSearch for one-way flight options from Des Moines to South Carolina. Find affordable one-way fares based on user searches. Data last updated July 21, 2026.
Search for one-way flight options from Des Moines to South Carolina. Find affordable one-way fares based on user searches. Data last updated July 21, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:07 pm
DSM
- CLT
1 stop19h 13m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$143
This CheapOair deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:19 pm
DSM
- CLT
1 stop25h 07m
Frontier
Deal found 7/17![Frontier logo]()
$147
This Kiwi.com deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/231:55 pm
DSM
- CLT
3 stops29h 16m
Multiple Airlines
Deal found 7/21![Multiple Airlines logo]()
$153
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:50 am
DSM
- CHS
1 stop4h 30m
Southwest
Deal found 7/20![Southwest logo]()
$159
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/223:22 pm
DSM
- GSP
1 stop4h 56m
United Airlines
Deal found 7/21![United Airlines logo]()
$159
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3012:45 pm
DSM
- MYR
1 stop19h 05m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$159
This Kiwi.com deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:12 pm
DSM
- CLT
3 stops47h 51m
Multiple Airlines
Deal found 7/17![Multiple Airlines logo]()
$159
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/196:10 am
DSM
- CLT
1 stop4h 45m
Southwest
Deal found 7/20![Southwest logo]()
$161
This Kiwi.com deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/163:41 pm
DSM
- CLT
1 stop17h 15m
Multiple Airlines
Deal found 7/19![Multiple Airlines logo]()
$162
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/239:28 am
DSM
- CHS
2 stops46h 10m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$163
This Southwest deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/227:15 am
DSM
- GSP
2 stops11h 10m
Southwest
Deal found 7/21![Southwest logo]()
$164
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:10 am
DSM
- MYR
2 stops8h 55m
Southwest
Deal found 7/20![Southwest logo]()
$164
Find flight deals from Des Moines to South Carolina
Keep the following information in mind while searching for Des Moines to South Carolina flight deals. Data was last updated July 21, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $253 (Kiwi.com) |
One-way from | $143 (Kiwi.com) |
Popular in | July |
Cheapest in | January |
Average price | $486 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 21, 2026.
Use the filters below to find and compare flights from Des Moines to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesColumbia
DSM - CAE
DSMCAE
Des Moines
Thu 9/10
1:30 pm-7:08 pm
1 stop4h 38m
Columbia Metropolitan
Sat 9/12
5:21 pm-11:12 pm
1 stop6h 51m
$285
Des MoinesColumbia
DSM - CAE
DSMCAE
Des Moines
Wed 8/12
6:00 am-2:21 pm
2 stops7h 21m
Columbia Metropolitan
Tue 8/18
6:25 am-12:20 pm
1 stop6h 55m
$302
Des MoinesSavannah
DSM - SAV
DSMSAV
Des Moines
Mon 8/17
5:45 am-3:09 pm
1 stop8h 24m
Savannah/Hilton Head
Mon 8/24
8:10 am-2:16 pm
1 stop7h 06m
$317
Des MoinesHilton Head Island
DSM - HHH
DSMHHH
Des Moines
Wed 9/30
8:03 am-1:45 pm
1 stop4h 42m
Hilton Head Island
Sat 10/3
2:20 pm-7:48 pm
1 stop6h 28m
$319
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Thu 8/20
5:40 am-7:20 pm
2 stops12h 40m
Myrtle Beach Intl
Mon 8/24
2:00 pm-10:10 pm
2 stops9h 10m
$333
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Wed 9/2
1:21 pm-9:34 pm
1 stop7h 13m
Charleston
Mon 9/7
6:30 am-10:26 am
1 stop4h 56m
$335
Des MoinesColumbia
DSM - CAE
DSMCAE
Des Moines
Wed 8/5
1:08 pm-8:56 pm
1 stop6h 48m
Columbia Metropolitan
Sun 8/9
8:34 pm-11:48 pm
1 stop4h 14m
$339
Des MoinesSavannah
DSM - SAV
DSMSAV
Des Moines
Wed 9/2
3:20 pm-9:19 pm
1 stop4h 59m
Savannah/Hilton Head
Sun 9/6
6:00 am-2:16 pm
2 stops9h 16m
$341
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Sat 10/17
5:50 am-5:15 pm
2 stops10h 25m
Myrtle Beach Intl
Sat 10/24
11:40 am-8:45 pm
2 stops10h 05m
$347
Des MoinesColumbia
DSM - CAE
DSMCAE
Des Moines
Wed 8/12
6:00 am-2:21 pm
2 stops7h 21m
Columbia Metropolitan
Mon 8/17
10:22 am-9:23 pm
2 stops12h 01m
$352
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Des Moines to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Des Moines with our price prediction graph.
DSM-MYR
DSM-CHS
DSM-GSP
DSM-CAE
DSM-SAV
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to South Carolina
DSM-USSC
DSM-MYR
DSM-CHS
DSM-GSP
DSM-CAE
What is the cheapest month to book a flight from Des Moines to South Carolina?
Currently, September is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $338). Flying from Des Moines to South Carolina in March is currently the most expensive (average of $473). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to South Carolina?
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated July 21, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Des Moines to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Food
7.0
Overall
8.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Entertainment
7.5
Food
7.0
Overall
8.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Entertainment
7.5
Food
7.0
Overall
8.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Entertainment
7.5
Food
7.0
Overall
8.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Entertainment
7.5
Food
7.0
Overall
8.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Des Moines to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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Des Moines and South Carolina flights
Browse other Des Moines and South Carolina flight options. Last updated on July 21, 2026.
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Check out other popular destinations found by fellow travelers in 2026
Des Moines to South Carolina flights
Consider these flights traveling from Des Moines to South Carolina.
Top 4 airlines flying from Des Moines to South Carolina
Discover the top 4 airlines that operate flights from Des Moines to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 21, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$233 | Average$423 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$262 | Average$412 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$266 | Average$471 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$344 | Average$412 | FlexibilityNo cancel fee | On-time63% |