$117+ Cheap flights from Des Moines (DSM) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/27. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Jun 29 — Jul 61
Round-trip
1 adult, Economy
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Cheapest flights from Des Moines to South CarolinaExplore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 30, 2026.
Explore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 30, 2026.
This CheapOair deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/192:16 pm
DSM
- CLT
1 stop27h 03m
Frontier
Sun 8/237:14 pm
CLT
- DSM
1 stop19h 17m
Frontier
Deal found 5/26![Frontier logo]()
$260
This Southwest deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/65:10 am
DSM
- CLT
1 stop4h 45m
Southwest
Wed 6/101:25 pm
CLT
- DSM
2 stops10h 20m
Southwest
Deal found 5/26![Southwest logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:07 pm
DSM
- CLT
1 stop26h 00m
Multiple Airlines
Sun 8/166:41 pm
CLT
- DSM
1 stop23h 36m
Multiple Airlines
Deal found 5/25![Multiple Airlines logo]()
$289
This American Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:45 pm
DSM
- CHS
1 stop6h 21m
American Airlines
Sat 9/266:20 am
CHS
- DSM
1 stop6h 44m
American Airlines
Deal found 5/29![American Airlines logo]()
$297
This Delta deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/124:15 pm
DSM
- SAV
1 stop6h 49m
Delta
Thu 9/176:45 am
SAV
- DSM
1 stop4h 58m
Delta
Deal found 5/29![Delta logo]()
$297
This Southwest deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/42:40 pm
DSM
- CHS
1 stop5h 30m
Southwest
Tue 8/117:35 am
CHS
- DSM
1 stop5h 15m
Southwest
Deal found 5/28![Southwest logo]()
$300
This United Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/193:22 pm
DSM
- CHS
1 stop5h 12m
United Airlines
Sat 9/266:00 am
CHS
- DSM
2 stops7h 34m
United Airlines
Deal found 5/29![United Airlines logo]()
$302
This American Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/138:50 pm
DSM
- CLT
1 stop10h 20m
American Airlines
Tue 7/1411:31 am
CLT
- DSM
Nonstop2h 25m
American Airlines
Deal found 5/27![American Airlines logo]()
$303
This American Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/302:13 pm
DSM
- CHS
1 stop6h 55m
American Airlines
Sat 10/32:05 pm
CHS
- DSM
1 stop6h 16m
American Airlines
Deal found 5/29![American Airlines logo]()
$306
This Kiwi.com deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/214:14 pm
DSM
- CHS
1 stop15h 54m
Multiple Airlines
Thu 7/237:47 pm
CHS
- DSM
1 stop21h 03m
Multiple Airlines
Deal found 5/27![Multiple Airlines logo]()
$309
This American Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/177:11 am
DSM
- CAE
1 stop6h 31m
American Airlines
Mon 7/207:23 pm
CAE
- DSM
1 stop5h 35m
American Airlines
Deal found 5/26![American Airlines logo]()
$309
This United Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/18:00 am
DSM
- CHS
1 stop4h 58m
United Airlines
Wed 9/26:30 am
CHS
- DSM
1 stop4h 56m
United Airlines
Deal found 5/29![United Airlines logo]()
$313
Best flights from Des Moines to South CarolinaDiscover carefully curated flight deals from Des Moines to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 30, 2026.
Discover carefully curated flight deals from Des Moines to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 30, 2026.
This American Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/177:11 am
DSM
- CAE
1 stop6h 31m
American Airlines
Mon 7/207:23 pm
CAE
- DSM
1 stop5h 35m
American Airlines
Deal found 5/26![American Airlines logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/105:30 pm
DSM
- GSP
2 stops37h 05m
Allegiant Air
Fri 7/173:10 pm
GSP
- DSM
1 stop8h 05m
Allegiant Air
Deal found 5/29![Allegiant Air logo]()
$314
This United Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/13:02 pm
DSM
- CHS
1 stop6h 09m
United Airlines
Wed 9/27:00 am
CHS
- DSM
2 stops8h 16m
United Airlines
Deal found 5/29![United Airlines logo]()
$318
This Southwest deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/135:10 am
DSM
- CLT
1 stop4h 45m
Southwest
Tue 7/147:05 pm
CLT
- DSM
1 stop4h 45m
Southwest
Deal found 5/27![Southwest logo]()
$325
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/232:25 pm
DSM
- GSP
1 stop4h 55m
Delta
Tue 8/45:20 pm
GSP
- DSM
1 stop6h 17m
Delta
Deal found 5/28![Delta logo]()
$335
This American Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/32:21 pm
DSM
- CAE
1 stop7h 35m
American Airlines
Fri 9/116:47 pm
CAE
- DSM
1 stop5h 54m
American Airlines
Deal found 5/28![American Airlines logo]()
$322
This Southwest deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/13:45 pm
DSM
- CHS
1 stop4h 40m
Southwest
Tue 7/76:10 am
CHS
- DSM
1 stop6h 20m
Southwest
Deal found 5/27![Southwest logo]()
$335
This Delta deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2811:30 am
DSM
- SAV
1 stop5h 32m
Delta
Tue 8/410:23 am
SAV
- DSM
1 stop4h 42m
Delta
Deal found 5/27![Delta logo]()
$335
This United Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/38:00 am
DSM
- HHH
1 stop5h 21m
United Airlines
Mon 7/63:05 pm
HHH
- DSM
1 stop7h 17m
United Airlines
Deal found 5/29![United Airlines logo]()
$340
This Southwest deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/253:50 pm
DSM
- CLT
1 stop5h 00m
Southwest
Sun 9/277:35 am
CLT
- DSM
1 stop5h 00m
Southwest
Deal found 5/25![Southwest logo]()
$335
This Delta deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/282:34 pm
DSM
- SAV
1 stop5h 27m
Delta
Sat 10/310:14 am
SAV
- DSM
1 stop6h 01m
Delta
Deal found 5/29![Delta logo]()
$338
This American Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/75:00 am
DSM
- SAV
2 stops8h 27m
American Airlines
Tue 7/148:47 am
SAV
- DSM
1 stop5h 09m
American Airlines
Deal found 5/25![American Airlines logo]()
$340
This United Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/291:10 pm
DSM
- SAV
1 stop7h 09m
United Airlines
Wed 9/24:59 pm
SAV
- DSM
1 stop5h 24m
United Airlines
Deal found 5/29![United Airlines logo]()
$345
This Southwest deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/174:40 pm
DSM
- CLT
2 stops5h 40m
Southwest
Tue 7/217:05 pm
CLT
- DSM
1 stop4h 45m
Southwest
Deal found 5/25![Southwest logo]()
$340
This American Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/177:00 am
DSM
- CHS
1 stop8h 50m
American Airlines
Tue 9/224:31 pm
CHS
- DSM
1 stop7h 42m
American Airlines
Deal found 5/25![American Airlines logo]()
$355
This United Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/261:24 pm
DSM
- SAV
1 stop5h 52m
United Airlines
Wed 9/304:23 pm
SAV
- DSM
1 stop6h 00m
United Airlines
Deal found 5/28![United Airlines logo]()
$355
This Delta deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/302:34 pm
DSM
- CHS
1 stop4h 56m
Delta
Sat 10/36:00 am
CHS
- DSM
1 stop5h 43m
Delta
Deal found 5/29![Delta logo]()
$367
This Southwest deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/45:10 am
DSM
- CLT
2 stops6h 10m
Southwest
Sat 7/116:00 pm
CLT
- DSM
1 stop5h 55m
Southwest
Deal found 5/26![Southwest logo]()
$340
This Delta deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:37 pm
DSM
- GSP
1 stop4h 17m
Delta
Tue 1/265:05 pm
GSP
- DSM
1 stop6h 24m
Delta
Deal found 5/27![Delta logo]()
$371
This American Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/26:02 am
DSM
- MYR
1 stop6h 04m
American Airlines
Wed 7/84:43 pm
MYR
- DSM
1 stop8h 15m
American Airlines
Deal found 5/25![American Airlines logo]()
$371
This Southwest deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/187:00 am
DSM
- CLT
2 stops9h 50m
Southwest
Mon 9/2111:50 am
CLT
- DSM
2 stops10h 25m
Southwest
Deal found 5/26![Southwest logo]()
$345
This United Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:00 am
DSM
- GSP
2 stops7h 20m
United Airlines
Wed 1/272:54 pm
GSP
- DSM
2 stops7h 23m
United Airlines
Deal found 5/27![United Airlines logo]()
$381
This Delta deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:00 pm
DSM
- SAV
1 stop5h 54m
Delta
Mon 7/66:43 am
SAV
- DSM
1 stop5h 00m
Delta
Deal found 5/27![Delta logo]()
$371
This Southwest deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/245:20 am
DSM
- SAV
2 stops11h 25m
Southwest
Wed 7/16:35 pm
SAV
- DSM
1 stop5h 10m
Southwest
Deal found 5/27![Southwest logo]()
$346
This United Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/296:00 am
DSM
- HHH
1 stop7h 03m
United Airlines
Wed 9/22:48 pm
HHH
- DSM
1 stop7h 35m
United Airlines
Deal found 5/28![United Airlines logo]()
$399
This Delta deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/186:39 pm
DSM
- MYR
1 stop4h 20m
Delta
Wed 6/2411:32 am
MYR
- DSM
1 stop6h 51m
Delta
Deal found 5/25![Delta logo]()
$381
This Southwest deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/175:20 am
DSM
- CHS
2 stops9h 50m
Southwest
Wed 6/242:10 pm
CHS
- DSM
2 stops9h 35m
Southwest
Deal found 5/27![Southwest logo]()
$351
This American Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/288:03 am
DSM
- HHH
1 stop4h 42m
American Airlines
Sat 10/32:15 pm
HHH
- DSM
1 stop6h 08m
American Airlines
Deal found 5/29![American Airlines logo]()
$445
This Southwest deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:40 am
DSM
- MYR
1 stop4h 30m
Southwest
Wed 10/77:10 am
MYR
- DSM
1 stop5h 15m
Southwest
Deal found 5/29![Southwest logo]()
$366
This Delta deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/105:41 am
DSM
- GSP
1 stop5h 33m
Delta
Fri 7/175:16 pm
GSP
- DSM
1 stop6h 13m
Delta
Deal found 5/26![Delta logo]()
$407
Last-minute flights from Des Moines to South CarolinaDiscover last-minute flight deals from Des Moines to South Carolina. Data last updated May 30, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to South Carolina. Data last updated May 30, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/32:16 pm
DSM
- CLT
1 stop27h 02m
Frontier
Sun 6/147:14 pm
CLT
- DSM
1 stop19h 17m
Frontier
Deal found 5/27![Frontier logo]()
$350
This Southwest deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/54:40 pm
DSM
- CLT
1 stop4h 10m
Southwest
Mon 6/87:05 pm
CLT
- DSM
1 stop5h 25m
Southwest
Deal found 5/27![Southwest logo]()
$325
This Southwest deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/65:10 am
DSM
- CLT
1 stop4h 45m
Southwest
Wed 6/101:25 pm
CLT
- DSM
2 stops10h 20m
Southwest
Deal found 5/26![Southwest logo]()
$274
This Southwest deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/133:35 pm
DSM
- CLT
1 stop4h 10m
Southwest
Tue 6/161:25 pm
CLT
- DSM
2 stops10h 20m
Southwest
Deal found 5/27![Southwest logo]()
$340
This Southwest deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/154:40 pm
DSM
- CLT
1 stop4h 10m
Southwest
Sat 6/207:50 am
CLT
- DSM
1 stop4h 45m
Southwest
Deal found 5/27![Southwest logo]()
$363
This Southwest deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/173:45 pm
DSM
- CHS
1 stop4h 40m
Southwest
Wed 6/246:10 am
CHS
- DSM
1 stop6h 20m
Southwest
Deal found 5/27![Southwest logo]()
$335
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/232:25 pm
DSM
- GSP
1 stop4h 55m
Delta
Tue 8/45:20 pm
GSP
- DSM
1 stop6h 17m
Delta
Deal found 5/28![Delta logo]()
$335
This Southwest deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/235:20 am
DSM
- GSP
2 stops12h 40m
Southwest
Tue 8/41:20 pm
GSP
- DSM
2 stops9h 35m
Southwest
Deal found 5/28![Southwest logo]()
$351
This American Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/243:22 pm
DSM
- SAV
1 stop5h 29m
American Airlines
Wed 7/17:34 pm
SAV
- DSM
1 stop5h 16m
American Airlines
Deal found 5/27![American Airlines logo]()
$335
This Southwest deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/245:20 am
DSM
- SAV
2 stops11h 25m
Southwest
Wed 7/16:35 pm
SAV
- DSM
1 stop5h 10m
Southwest
Deal found 5/27![Southwest logo]()
$346
This American Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/261:33 pm
DSM
- MYR
1 stop5h 54m
American Airlines
Wed 7/16:06 pm
MYR
- DSM
1 stop7h 01m
American Airlines
Deal found 5/26![American Airlines logo]()
$371
This American Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/285:00 am
DSM
- CHS
1 stop5h 33m
American Airlines
Wed 7/17:47 pm
CHS
- DSM
1 stop5h 03m
American Airlines
Deal found 5/26![American Airlines logo]()
$371
One-way flights from Des Moines to South CarolinaSearch for one-way flight options from Des Moines to South Carolina. Find affordable one-way fares based on user searches. Data last updated May 30, 2026.
Search for one-way flight options from Des Moines to South Carolina. Find affordable one-way fares based on user searches. Data last updated May 30, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/274:40 pm
DSM
- CLT
1 stop27h 27m
Multiple Airlines
Deal found 5/30![Multiple Airlines logo]()
$117
This Southwest deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:10 am
DSM
- CLT
1 stop4h 45m
Southwest
Deal found 5/29![Southwest logo]()
$134
This Kiwi.com deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/64:40 pm
DSM
- CHS
1 stop24h 34m
Multiple Airlines
Deal found 5/28![Multiple Airlines logo]()
$136
This Kiwi.com deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/134:40 pm
DSM
- MYR
1 stop16h 10m
Multiple Airlines
Deal found 5/29![Multiple Airlines logo]()
$139
This Kiwi.com deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/204:40 pm
DSM
- CLT
1 stop27h 27m
Multiple Airlines
Deal found 5/27![Multiple Airlines logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/274:40 pm
DSM
- CHS
1 stop24h 34m
Multiple Airlines
Deal found 5/29![Multiple Airlines logo]()
$142
This CheapOair deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/222:26 pm
DSM
- CLT
1 stop26h 53m
Frontier
Deal found 5/30![Frontier logo]()
$145
This American Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/228:10 am
DSM
- CHS
1 stop4h 06m
American Airlines
Deal found 5/29![American Airlines logo]()
$149
This Kiwi.com deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/511:48 am
DSM
- MYR
1 stop26h 26m
Multiple Airlines
Deal found 5/25![Multiple Airlines logo]()
$150
This Kiwi.com deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/235:08 pm
DSM
- CLT
2 stops26h 59m
Multiple Airlines
Deal found 5/30![Multiple Airlines logo]()
$151
This Kiwi.com deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/301:55 pm
DSM
- GSP
2 stops25h 05m
Multiple Airlines
Deal found 5/27![Multiple Airlines logo]()
$154
This Southwest deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/54:40 pm
DSM
- CLT
1 stop4h 10m
Southwest
Deal found 5/27![Southwest logo]()
$158
Find flight deals from Des Moines to South Carolina
Keep the following information in mind while searching for Des Moines to South Carolina flight deals. Data was last updated May 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $260 (CheapOair) |
One-way from | $119 (Kiwi.com) |
Popular in | June |
Cheapest in | January |
Average price | $442 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 30, 2026.
Use the filters below to find and compare flights from Des Moines to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesColumbia
DSM - CAE
DSMCAE
Des Moines
Fri 7/17
7:11 am-2:42 pm
1 stop6h 31m
Columbia Metropolitan
Mon 7/20
7:23 pm-11:58 pm
1 stop5h 35m
$309
Des MoinesGreenville
DSM - GSP
DSMGSP
Des Moines
Fri 7/10
5:30 pm-7:35 am
2 stops37h 05m
Greenville
Fri 7/17
3:10 pm-10:15 pm
1 stop8h 05m
$314
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Tue 9/1
3:02 pm-10:11 pm
1 stop6h 09m
Charleston
Wed 9/2
7:00 am-2:16 pm
2 stops8h 16m
$318
Des MoinesColumbia
DSM - CAE
DSMCAE
Des Moines
Thu 9/3
2:21 pm-10:56 pm
1 stop7h 35m
Columbia Metropolitan
Fri 9/11
6:47 pm-11:41 pm
1 stop5h 54m
$322
Quickest round-trip
Des MoinesCharlotte
DSM - CLT
DSMCLT
Des Moines
Mon 7/13
5:10 am-10:55 am
1 stop4h 45m
Charlotte Douglas
Tue 7/14
7:05 pm-10:50 pm
1 stop4h 45m
$325
Des MoinesGreenville
DSM - GSP
DSMGSP
Des Moines
Tue 6/23
2:25 pm-8:20 pm
1 stop4h 55m
Greenville
Tue 8/4
5:20 pm-10:37 pm
1 stop6h 17m
$335
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Wed 7/1
3:45 pm-9:25 pm
1 stop4h 40m
Charleston
Tue 7/7
6:10 am-11:30 am
1 stop6h 20m
$335
Des MoinesSavannah
DSM - SAV
DSMSAV
Des Moines
Tue 7/28
11:30 am-6:02 pm
1 stop5h 32m
Savannah/Hilton Head
Tue 8/4
10:23 am-2:05 pm
1 stop4h 42m
$335
Des MoinesCharlotte
DSM - CLT
DSMCLT
Des Moines
Fri 9/25
3:50 pm-9:50 pm
1 stop5h 00m
Charlotte Douglas
Sun 9/27
7:35 am-11:35 am
1 stop5h 00m
$335
Des MoinesSavannah
DSM - SAV
DSMSAV
Des Moines
Mon 9/28
2:34 pm-9:01 pm
1 stop5h 27m
Savannah/Hilton Head
Sat 10/3
10:14 am-3:15 pm
1 stop6h 01m
$338
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Des Moines to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Des Moines with our price prediction graph.
DSM-CLT
DSM-CHS
DSM-MYR
DSM-GSP
DSM-SAV
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to South Carolina
DSM-USSC
DSM-CLT
DSM-CHS
DSM-MYR
DSM-GSP
What is the cheapest month to book a flight from Des Moines to South Carolina?
Currently, November is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $118). Flying from Des Moines to South Carolina in May is currently the most expensive (average of $321). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to South Carolina?
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated May 30, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Des Moines to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Overall
8.0
Entertainment
7.5
Comfort
8.0
Food
7.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Crew
8.6
Overall
8.0
Entertainment
7.5
Comfort
8.0
Food
7.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Crew
8.6
Overall
8.0
Entertainment
7.5
Comfort
8.0
Food
7.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Crew
8.6
Overall
8.0
Entertainment
7.5
Comfort
8.0
Food
7.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Crew
8.6
Overall
8.0
Entertainment
7.5
Comfort
8.0
Food
7.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Des Moines to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Des Moines to South Carolina by cabin class
Find flights from Des Moines to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and South Carolina flights
Browse other Des Moines and South Carolina flight options. Last updated on May 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Des Moines to South Carolina flights
Consider these flights traveling from Des Moines to South Carolina.
Top 4 airlines flying from Des Moines to South Carolina
Discover the top 4 airlines that operate flights from Des Moines to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$237 | Average$374 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$237 | Average$411 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$266 | Average$467 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$272 | Average$406 | FlexibilityNo cancel fee | On-time63% |