$144+ Cheap flights from Des Moines to Charleston (DSM - CHS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/23. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Aug 7 — Aug 141
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Charleston with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Charleston
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Cheapest flights from Des Moines to CharlestonExplore the most affordable flight options available from Des Moines to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 8, 2026.
Explore the most affordable flight options available from Des Moines to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 8, 2026.
This American Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/58:00 am
DSM
- CHS
1 stop4h 16m
American Airlines
Wed 8/197:50 pm
CHS
- DSM
1 stop5h 30m
American Airlines
Deal found 7/7![American Airlines logo]()
$263
This Southwest deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/203:50 pm
DSM
- CHS
1 stop4h 35m
Southwest
Thu 8/277:00 am
CHS
- DSM
1 stop5h 25m
Southwest
Deal found 7/6![Southwest logo]()
$264
This Southwest deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/75:20 am
DSM
- CHS
2 stops6h 55m
Southwest
Tue 11/101:25 pm
CHS
- DSM
2 stops9h 40m
Southwest
Deal found 7/7![Southwest logo]()
$275
This Southwest deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/52:40 pm
DSM
- CHS
1 stop5h 30m
Southwest
Wed 8/1910:45 am
CHS
- DSM
2 stops11h 15m
Southwest
Deal found 7/7![Southwest logo]()
$276
This American Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/711:30 am
DSM
- CHS
1 stop6h 00m
American Airlines
Tue 11/107:53 pm
CHS
- DSM
1 stop5h 28m
American Airlines
Deal found 7/7![American Airlines logo]()
$280
This American Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/172:44 pm
DSM
- CHS
1 stop7h 15m
American Airlines
Mon 9/217:46 pm
CHS
- DSM
1 stop5h 18m
American Airlines
Deal found 7/8![American Airlines logo]()
$299
This American Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/102:44 pm
DSM
- CHS
1 stop7h 15m
American Airlines
Sun 9/138:41 pm
CHS
- DSM
1 stop4h 11m
American Airlines
Deal found 7/8![American Airlines logo]()
$335
This Southwest deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/213:50 pm
DSM
- CHS
1 stop4h 35m
Southwest
Fri 8/284:05 pm
CHS
- DSM
1 stop6h 10m
Southwest
Deal found 7/7![Southwest logo]()
$336
This United Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/258:00 am
DSM
- CHS
1 stop4h 58m
United Airlines
Wed 8/264:38 pm
CHS
- DSM
1 stop5h 45m
United Airlines
Deal found 7/7![United Airlines logo]()
$343
Best flights from Des Moines to CharlestonDiscover carefully curated flight deals from Des Moines to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 8, 2026.
Discover carefully curated flight deals from Des Moines to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 8, 2026.
This Delta deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:54 pm
DSM
- CHS
1 stop4h 03m
Delta
Fri 10/93:20 pm
CHS
- DSM
1 stop4h 51m
Delta
Deal found 7/7![Delta logo]()
$263
This Southwest deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/213:50 pm
DSM
- CHS
1 stop4h 35m
Southwest
Fri 8/281:15 pm
CHS
- DSM
2 stops9h 55m
Southwest
Deal found 7/7![Southwest logo]()
$341
This United Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/258:00 am
DSM
- CHS
1 stop4h 58m
United Airlines
Wed 8/264:38 pm
CHS
- DSM
1 stop5h 45m
United Airlines
Deal found 7/7![United Airlines logo]()
$343
This Delta deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:35 pm
DSM
- CHS
1 stop4h 24m
Delta
Mon 8/245:06 pm
CHS
- DSM
1 stop6h 31m
Delta
Deal found 7/3![Delta logo]()
$355
This Southwest deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:35 am
DSM
- CHS
1 stop10h 05m
Southwest
Sun 10/256:25 am
CHS
- DSM
2 stops8h 10m
Southwest
Deal found 7/7![Southwest logo]()
$367
This United Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:00 am
DSM
- CHS
1 stop4h 58m
United Airlines
Thu 9/37:00 am
CHS
- DSM
2 stops8h 16m
United Airlines
Deal found 7/3![United Airlines logo]()
$440
This Delta deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:55 am
DSM
- CHS
1 stop6h 29m
Delta
Tue 11/106:30 am
CHS
- DSM
1 stop4h 48m
Delta
Deal found 7/4![Delta logo]()
$407
This Southwest deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:40 am
DSM
- CHS
2 stops10h 00m
Southwest
Fri 8/214:05 pm
CHS
- DSM
1 stop6h 10m
Southwest
Deal found 7/5![Southwest logo]()
$412
This Delta deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/25:40 am
DSM
- CHS
1 stop6h 15m
Delta
Mon 11/95:30 pm
CHS
- DSM
1 stop4h 54m
Delta
Deal found 7/5![Delta logo]()
$407
This Southwest deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/52:40 pm
DSM
- CHS
1 stop5h 30m
Southwest
Tue 8/111:25 pm
CHS
- DSM
2 stops9h 30m
Southwest
Deal found 7/6![Southwest logo]()
$412
Last-minute flights from Des Moines to CharlestonDiscover last-minute flight deals from Des Moines to Charleston. Data last updated July 8, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Charleston. Data last updated July 8, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/58:00 am
DSM
- CHS
1 stop4h 16m
American Airlines
Wed 8/197:50 pm
CHS
- DSM
1 stop5h 30m
American Airlines
Deal found 7/7![American Airlines logo]()
$263
This Southwest deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/52:40 pm
DSM
- CHS
1 stop5h 30m
Southwest
Wed 8/1910:45 am
CHS
- DSM
2 stops11h 15m
Southwest
Deal found 7/7![Southwest logo]()
$276
This American Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/64:13 pm
DSM
- CHS
1 stop5h 37m
American Airlines
Mon 8/107:00 am
CHS
- DSM
1 stop7h 25m
American Airlines
Deal found 7/3![American Airlines logo]()
$355
This Southwest deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/203:50 pm
DSM
- CHS
1 stop4h 35m
Southwest
Thu 8/277:00 am
CHS
- DSM
1 stop5h 25m
Southwest
Deal found 7/6![Southwest logo]()
$264
This Southwest deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/213:50 pm
DSM
- CHS
1 stop4h 35m
Southwest
Fri 8/284:05 pm
CHS
- DSM
1 stop6h 10m
Southwest
Deal found 7/7![Southwest logo]()
$336
This United Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/258:00 am
DSM
- CHS
1 stop4h 58m
United Airlines
Wed 8/264:38 pm
CHS
- DSM
1 stop5h 45m
United Airlines
Deal found 7/7![United Airlines logo]()
$343
One-way flights from Des Moines to CharlestonSearch for one-way flight options from Des Moines to Charleston. Find affordable one-way fares based on user searches. Data last updated July 8, 2026.
Search for one-way flight options from Des Moines to Charleston. Find affordable one-way fares based on user searches. Data last updated July 8, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/239:28 am
DSM
- CHS
2 stops46h 10m
Multiple Airlines
Deal found 7/4![Multiple Airlines logo]()
$144
This United Airlines deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/236:00 am
DSM
- CHS
1 stop6h 58m
United Airlines
Deal found 7/4![United Airlines logo]()
$204
This Southwest deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/296:10 pm
DSM
- CHS
1 stop4h 30m
Southwest
Deal found 7/6![Southwest logo]()
$224
This Kiwi.com deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/193:59 pm
DSM
- CHS
3 stops53h 48m
Multiple Airlines
Deal found 7/4![Multiple Airlines logo]()
$231
This United Airlines deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/193:24 pm
DSM
- CHS
1 stop5h 24m
United Airlines
Deal found 7/4![United Airlines logo]()
$244
This Kiwi.com deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/299:20 pm
DSM
- CHS
2 stops34h 18m
Multiple Airlines
Deal found 7/7![Multiple Airlines logo]()
$333
Find flight deals from Des Moines to Charleston
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 8, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $263 (American Airlines) |
One-way from | $144 (Kiwi.com) |
Popular in | February |
Cheapest in | September |
Average price | $406 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 8, 2026.
Use the filters below to find and compare flights from Des Moines to Charleston that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Mon 10/5
6:54 pm-11:57 pm
1 stop4h 03m
Charleston
Fri 10/9
3:20 pm-7:11 pm
1 stop4h 51m
$263
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Fri 8/21
3:50 pm-9:25 pm
1 stop4h 35m
Charleston
Fri 8/28
1:15 pm-10:10 pm
2 stops9h 55m
$341
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Tue 8/25
8:00 am-1:58 pm
1 stop4h 58m
Charleston
Wed 8/26
4:38 pm-9:23 pm
1 stop5h 45m
$343
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Mon 8/17
6:35 pm-11:59 pm
1 stop4h 24m
Charleston
Mon 8/24
5:06 pm-10:37 pm
1 stop6h 31m
$355
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Wed 10/21
5:35 am-4:40 pm
1 stop10h 05m
Charleston
Sun 10/25
6:25 am-1:35 pm
2 stops8h 10m
$367
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Sat 11/7
6:55 am-2:24 pm
1 stop6h 29m
Charleston
Tue 11/10
6:30 am-10:18 am
1 stop4h 48m
$407
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Mon 11/2
5:40 am-12:55 pm
1 stop6h 15m
Charleston
Mon 11/9
5:30 pm-9:24 pm
1 stop4h 54m
$407
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Mon 8/17
5:40 am-4:40 pm
2 stops10h 00m
Charleston
Fri 8/21
4:05 pm-9:15 pm
1 stop6h 10m
$412
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Wed 8/5
2:40 pm-9:10 pm
1 stop5h 30m
Charleston
Tue 8/11
1:25 pm-9:55 pm
2 stops9h 30m
$412
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Mon 8/24
8:00 am-1:58 pm
1 stop4h 58m
Charleston
Thu 9/3
7:00 am-2:16 pm
2 stops8h 16m
$440
Showing 1-10 of 15 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Charleston
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Charleston in July.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Charleston flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Charleston flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Charleston flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Charleston flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Charleston
Have a flexible travel schedule? Discover the best time to fly to Charleston from Des Moines with our price prediction graph.
DSM-CHS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Charleston
What is the cheapest month to book a flight from Des Moines to Charleston?
Currently, September is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $283). Flying from Des Moines to Charleston in February is currently the most expensive (average of $608). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Charleston?
Reviews of airlines servicing Charleston
Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated July 8, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Des Moines to Charleston have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Entertainment
7.8
Overall
7.8
Crew
8.5
Comfort
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Entertainment
7.8
Overall
7.8
Crew
8.5
Comfort
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Entertainment
7.8
Overall
7.8
Crew
8.5
Comfort
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Entertainment
7.8
Overall
7.8
Crew
8.5
Comfort
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Charleston?
Book flights to Charleston if you plan to visit one of these locationsNorth Charleston
Santee
Summerville
Walterboro
Isle of Palms
Mount Pleasant
Goose Creek
Edisto Beach
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Des Moines to Charleston
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Other flights to Charleston
Explore flights to Charleston departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 8, 2026.
Complete your trip
Complete your trip to Charleston by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Des Moines to Charleston, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Charleston flights
Browse other Des Moines and Charleston flight options. Last updated on July 8, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on July 8, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Des Moines to Charleston
Discover the top 3 airlines that operate flights from Des Moines to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 8, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$242 | Average$380 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$266 | Average$398 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$280 | Average$406 | FlexibilityNo cancel fee | On-timeN/A |