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$119+ Cheap flights from Des Moines to Charleston (DSM - CHS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/7. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Jul 7 — Jul 141
Mon 7/7
Mon 7/14
1 adult, Economy
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Cheapflights Tip: The best prices from Des Moines to Charleston are usually found in May or September, booked 86 days in advance, depart on a Monday or Friday and return on a Wednesday

Cheap flight deals from Des Moines to Charleston

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 2, 2025.

Round-trip from

$237
(Delta)

One-way from

$119
(American Airlines)

Popular in

March

Cheapest in

May

Average price

$366
From Des Moines to Charleston
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One-way flight from Des Moines to Charleston
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Highest demand for flights based on searches. 12% potential increase in price ($57 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($16 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Des Moines to Charleston

Cheapest flights from Des Moines to Charleston
Explore the most affordable flight options available from Des Moines to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2025.

This Delta deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/273:12 pmDSM - CHS
1 stop6h 14mDelta
Mon 9/15:15 amCHS - DSM
1 stop6h 23mDelta
Deal found 7/2$237
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/147:00 amDSM - CHS
1 stop4h 16mAmerican Airlines
Thu 8/216:06 pmCHS - DSM
1 stop6h 39mAmerican Airlines
Deal found 6/30$238
This Mytrip deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/147:15 pmDSM - CHS
2 stops22h 57mMultiple Airlines
Thu 8/218:17 pmCHS - DSM
2 stops25h 24mMultiple Airlines
Deal found 6/30$278
This United Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/271:10 pmDSM - CHS
1 stop4h 58mUnited Airlines
Wed 9/36:00 amCHS - DSM
2 stops12h 14mUnited Airlines
Deal found 7/1$312
This Southwest deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/68:00 amDSM - CHS
2 stops10h 30mSouthwest
Mon 11/102:50 pmCHS - DSM
1 stop7h 10mSouthwest
Deal found 7/1$334

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2025.
Use the filters below to find and compare flights from Des Moines to Charleston that are best for you.

Fly from

Des Moines

Fly to

Charleston

Route

Depart

Return

Price

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 8/27

3:12 pm-10:26 pm

1 stop6h 14m

Charleston

Mon 9/1

5:15 am-10:38 am

1 stop6h 23m

$237

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Thu 8/14

7:00 am-12:16 pm

1 stop4h 16m

Charleston

Thu 8/21

6:06 pm-11:45 pm

1 stop6h 39m

$238

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Thu 8/14

7:15 pm-7:12 pm

2 stops22h 57m

Charleston

Thu 8/21

8:17 pm-8:41 pm

2 stops25h 24m

$278

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 8/27

1:10 pm-7:08 pm

1 stop4h 58m

Charleston

Wed 9/3

6:00 am-5:14 pm

2 stops12h 14m

$312

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 8/27

8:25 am-6:00 pm

2 stops8h 35m

Charleston

Mon 9/1

5:30 am-11:05 am

2 stops6h 35m

$335

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Thu 8/7

11:23 am-7:40 pm

1 stop7h 17m

$119

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 9/30

10:20 am-6:57 pm

2 stops7h 37m

$124

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 7/15

3:38 pm-9:33 pm

1 stop4h 55m

$214

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 7/15

2:21 pm-10:24 pm

3 stops31h 03m

$386

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/30

Best time to book a flight from Des Moines to Charleston

Have a flexible travel schedule? Discover the best time to fly to Charleston from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Charleston

How far ahead should I book a flight from Des Moines to Charleston?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Charleston. Price data was last updated on June 27, 2025.

The price you pay for your flight from Des Moines to Charleston may vary depending on when you book. For the best chance of a lower fare, look to book 86 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Des Moines to Charleston?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $217). Flying from Des Moines to Charleston in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Charleston

Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated July 2, 2025.
See what other customers who have flown with Southwest, Delta, and United Airlines from Des Moines to Charleston have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,272 reviews

Entertainment

7.6

Food

7.0

Overall

8.0

Boarding

8.2

Crew

8.6

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Southwest
8.0
Very good
4,272 reviews
Southwest
8.0
Very good
4,272 reviews

Entertainment

7.6

Food

7.0

Overall

8.0

Boarding

8.2

Crew

8.6

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Delta
8.0
Very good
7,983 reviews
Southwest
8.0
Very good
4,272 reviews

Entertainment

7.6

Food

7.0

Overall

8.0

Boarding

8.2

Crew

8.6

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
United Airlines
7.4
Good
8,861 reviews
Southwest
8.0
Very good
4,272 reviews

Entertainment

7.6

Food

7.0

Overall

8.0

Boarding

8.2

Crew

8.6

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,272 reviews

Entertainment

7.6

Food

7.0

Overall

8.0

Boarding

8.2

Crew

8.6

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Des Moines to Charleston round-trip?

    Flying on Delta is currently your cheapest option to Charleston, with prices starting at $237. Additional round-trip tickets that might be worth considering are offered by American Airlines and United Airlines, with the lowest prices starting at $238 and $312, respectively. Delta is currently priced 39% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from Des Moines to Charleston one-way?

    The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $119. However, be on the lookout for offers from Delta and United Airlines, as they are both options that can get you from Des Moines to Charleston for a low price.

  • Can I find deals for flights from Des Moines to Charleston that include hotel bookings?

    Yes. In addition to deals on Des Moines to Charleston flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Charleston?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Charleston.

  • Can I find deals for business class flights from Des Moines to Charleston?

    Yes. Cheapflights offers flight deals from Des Moines to Charleston by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Charleston?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $217). Flying from Des Moines to Charleston in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
North Charleston
Summerville
Walterboro
Mount Pleasant
Isle of Palms
Folly Beach
Santee
Edisto Beach

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Des Moines to Charleston

Discover the top 3 airlines that operate flights from Des Moines to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$237Average$394FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$270Average$379FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$315Average$565FlexibilityNo cancel feeOn-time69%

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