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$136+ Cheap flights from Des Moines to Greenville (DSM - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/21. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GSP
Apr 22 — Apr 291
Tue 4/22
Tue 4/29
1 adult, Economy
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Cheap flight deals from Des Moines to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 17, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$297
(Delta)

One-way from

$136
(American Airlines)

Popular in

November

Cheapest in

August

Average price

$410
Provider with most accurate pricing for Des Moines-Greenville flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Greenville flights.
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From Des Moines to Greenville
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One-way flight from Des Moines to Greenville
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Highest demand for flights based on searches. 15% potential increase in price ($74 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($26 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Des Moines to Greenville

Cheapest flights from Des Moines to Greenville
Explore the most affordable flight options available from Des Moines to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/25:50 pmDSM - GSP
1 stop4h 16mDelta
Thu 6/57:35 amGSP - DSM
1 stop4h 06mDelta
Deal found 4/16$303
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/85:00 amDSM - GSP
1 stop4h 53mAmerican Airlines
Tue 6/106:10 pmGSP - DSM
2 stops6h 42mAmerican Airlines
Deal found 4/17$344
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/26:00 amDSM - GSP
2 stops11h 35mSouthwest
Thu 6/510:30 amGSP - DSM
2 stops13h 25mSouthwest
Deal found 4/16$508
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/88:48 amDSM - GSP
2 stops24h 04mUnited Airlines
Sat 5/106:00 amGSP - DSM
2 stops11h 14mUnited Airlines
Deal found 4/17$542

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
Use the filters below to find and compare flights from Des Moines to Greenville that are best for you.

Fly from

Des Moines

Fly to

Greenville

Route

Depart

Return

Price

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Mon 6/2

5:50 pm-11:06 pm

1 stop4h 16m

Greenville

Thu 6/5

7:35 am-10:41 am

1 stop4h 06m

$303

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sun 6/8

5:00 am-10:53 am

1 stop4h 53m

Greenville

Tue 6/10

6:10 pm-11:52 pm

2 stops6h 42m

$344

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Mon 6/2

6:00 am-6:35 pm

2 stops11h 35m

Greenville

Thu 6/5

10:30 am-10:55 pm

2 stops13h 25m

$508

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 5/8

8:48 am-9:52 am

2 stops24h 04m

Greenville

Sat 5/10

6:00 am-4:14 pm

2 stops11h 14m

$542

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sun 9/14

7:20 am-3:00 pm

1 stop6h 40m

$184

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Tue 4/29

6:25 pm-11:53 pm

1 stop4h 28m

$264

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sun 9/14

3:15 pm-9:49 am

3 stops17h 34m

$393

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/17

Compare providers for flights from Des Moines to Greenville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Greenville in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*2 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Greenville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Greenville

What is the cheapest month to book a flight from Des Moines to Greenville?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Greenville (average of $329). Flying from Des Moines to Greenville in March is currently the most expensive (average of $384). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to GSP?

Find hourly flight availability from Des Moines to Greenville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 17, 2025.

When flying from Des Moines to Greenville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 15% versus a flight in the morning.

Rainfall in Greenville by month

Plan your trip to Greenville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Greenville ranges from 3.6 - 5.1 inches per month. March is typically the wettest month, when rainfall can reach 5.1 in. November is typically the driest time to visit Greenville when rainfall is around 3.6 in.

Temperature in Greenville by month

Plan your trip to Greenville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Greenville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 41.0 F).

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated April 17, 2025.
Read reviews from past customers who have flown Southwest, Delta and United Airlines from Des Moines to Greenville. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,280 reviews

Boarding

8.2

Overall

8.0

Food

7.1

Crew

8.6

Comfort

8.0

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Southwest
8.0
Very good
4,280 reviews
Southwest
8.0
Very good
4,280 reviews

Boarding

8.2

Overall

8.0

Food

7.1

Crew

8.6

Comfort

8.0

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Delta
8.0
Very good
7,917 reviews
Southwest
8.0
Very good
4,280 reviews

Boarding

8.2

Overall

8.0

Food

7.1

Crew

8.6

Comfort

8.0

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
United Airlines
7.4
Good
8,667 reviews
Southwest
8.0
Very good
4,280 reviews

Boarding

8.2

Overall

8.0

Food

7.1

Crew

8.6

Comfort

8.0

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,280 reviews

Boarding

8.2

Overall

8.0

Food

7.1

Crew

8.6

Comfort

8.0

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Des Moines to Greenville round-trip?

    Currently priced at $297, Delta will fly you from Des Moines to Greenville and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and United Airlines - these airlines can fly you to your destination from $304 and $308, respectively. These flights start at 28% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from Des Moines to Greenville one-way?

    $136 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on Delta and United Airlines, with prices starting from $264 and $393, respectively.

  • Can I find deals for flights from Des Moines to Greenville that include hotel bookings?

    Yes. In addition to deals on Des Moines to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Greenville.

  • Can I find deals for business class flights from Des Moines to Greenville?

    Yes. Cheapflights offers flight deals from Des Moines to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Greenville?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Greenville (average of $329). Flying from Des Moines to Greenville in March is currently the most expensive (average of $384). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Simpsonville
Seneca
Duncan
Anderson

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Top 2 airlines flying from Des Moines to Greenville

Discover the top 2 airlines that operate flights from Des Moines to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$286Average$401FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$306Average$421FlexibilityNo cancel feeOn-time71%

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