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$109+ Cheap flights from Des Moines to Greenville (DSM - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/1. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GSP
Jul 7 — Jul 141
Mon 7/7
Mon 7/14
1 adult, Economy
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Cheap flight deals from Des Moines to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 2, 2025.

Round-trip from

$237
(Delta)

One-way from

$109
(Mytrip)

Popular in

November

Cheapest in

August

Average price

$366
From Des Moines to Greenville
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One-way flight from Des Moines to Greenville
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Highest demand for flights based on searches. 15% potential increase in price ($72 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($27 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Des Moines to Greenville

Cheapest flights from Des Moines to Greenville
Explore the most affordable flight options available from Des Moines to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2025.

This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1410:18 amDSM - GSP
1 stop6h 26mDelta
Thu 8/215:59 pmGSP - DSM
1 stop5h 40mDelta
Deal found 6/30$237
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/117:08 amDSM - GSP
2 stops7h 26mAmerican Airlines
Tue 9/1611:27 amGSP - DSM
1 stop4h 53mAmerican Airlines
Deal found 6/30$242
This United Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/296:24 amDSM - GSP
2 stops9h 39mUnited Airlines
Tue 8/55:35 pmGSP - DSM
1 stop5h 12mUnited Airlines
Deal found 7/1$249
This Southwest deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/117:00 amDSM - GSP
2 stops13h 00mSouthwest
Tue 9/169:30 amGSP - DSM
2 stops13h 50mSouthwest
Deal found 6/30$258
This Mytrip deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/144:00 pmDSM - GSP
2 stops26h 27mMultiple Airlines
Thu 8/214:33 pmGSP - DSM
3 stops29h 08mMultiple Airlines
Deal found 6/30$558

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2025.
Use the filters below to find and compare flights from Des Moines to Greenville that are best for you.

Fly from

Des Moines

Fly to

Greenville

Route

Depart

Return

Price

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 8/14

10:18 am-5:44 pm

1 stop6h 26m

Greenville

Thu 8/21

11:17 am-4:45 pm

1 stop6h 28m

$237

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 9/11

7:08 am-3:34 pm

2 stops7h 26m

Greenville

Tue 9/16

11:27 am-3:20 pm

1 stop4h 53m

$242

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Tue 7/29

6:24 am-5:03 pm

2 stops9h 39m

Greenville

Tue 8/5

5:35 pm-9:47 pm

1 stop5h 12m

$249

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 9/11

7:00 am-9:00 pm

2 stops13h 00m

Greenville

Tue 9/16

9:30 am-10:20 pm

2 stops13h 50m

$258

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 8/14

4:00 pm-7:27 pm

2 stops26h 27m

Greenville

Thu 8/21

4:33 pm-8:41 pm

3 stops29h 08m

$558

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Fri 8/1

7:30 am-2:59 pm

1 stop6h 29m

$109

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Fri 8/1

3:39 pm-11:53 pm

1 stop7h 14m

$126

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sun 9/14

5:00 am-10:56 am

1 stop4h 56m

$149

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sat 8/2

6:00 am-2:40 pm

1 stop7h 40m

$180

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sat 8/2

1:13 pm-7:26 pm

3 stops29h 13m

$303

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/30

Showing 1-10 of 11 results
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Best time to book a flight from Des Moines to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Greenville

What is the cheapest month to book a flight from Des Moines to Greenville?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Greenville (average of $329). Flying from Des Moines to Greenville in March is currently the most expensive (average of $385). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to GSP?

Find hourly flight availability from Des Moines to Greenville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 2, 2025.

When flying from Des Moines to Greenville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 15% versus a flight in the morning.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated July 2, 2025.
Get a feel of what it's like to fly with Southwest, Delta, and United Airlines from Des Moines to Greenville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,272 reviews

Entertainment

7.6

Food

7.0

Crew

8.6

Comfort

8.0

Boarding

8.2

Overall

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Southwest
8.0
Very good
4,272 reviews
Southwest
8.0
Very good
4,272 reviews

Entertainment

7.6

Food

7.0

Crew

8.6

Comfort

8.0

Boarding

8.2

Overall

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Delta
8.0
Very good
7,983 reviews
Southwest
8.0
Very good
4,272 reviews

Entertainment

7.6

Food

7.0

Crew

8.6

Comfort

8.0

Boarding

8.2

Overall

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
United Airlines
7.4
Good
8,861 reviews
Southwest
8.0
Very good
4,272 reviews

Entertainment

7.6

Food

7.0

Crew

8.6

Comfort

8.0

Boarding

8.2

Overall

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,272 reviews

Entertainment

7.6

Food

7.0

Crew

8.6

Comfort

8.0

Boarding

8.2

Overall

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Allegiant Air
7.2
Good
709 reviews
Southwest
8.0
Very good
4,272 reviews

Entertainment

7.6

Food

7.0

Crew

8.6

Comfort

8.0

Boarding

8.2

Overall

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Des Moines to Greenville round-trip?

    Currently priced at $237, Delta will fly you from Des Moines to Greenville and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and United Airlines - these airlines can fly you to your destination from $242 and $244, respectively. These flights start at 41% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from Des Moines to Greenville one-way?

    $109 is the cheapest one-way deal found within the past few days, from Allegiant Air. You may also be able to find cheap deals on Delta and American Airlines, with prices starting from $126 and $149, respectively.

  • Can I find deals for flights from Des Moines to Greenville that include hotel bookings?

    Yes. In addition to deals on Des Moines to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Greenville.

  • Can I find deals for business class flights from Des Moines to Greenville?

    Yes. Cheapflights offers flight deals from Des Moines to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Greenville?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Greenville (average of $329). Flying from Des Moines to Greenville in March is currently the most expensive (average of $385). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Simpsonville
Duncan
Seneca
Anderson

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Top 2 airlines flying from Des Moines to Greenville

Discover the top 2 airlines that operate flights from Des Moines to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$296Average$421FlexibilityNo cancel feeOn-time71%
DeltaCheapest$303Average$467FlexibilityNo cancel feeOn-timeN/A

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