$383+ Cheap flights from La Crosse to Charleston (LSE - CHS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/2. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — CHS
Nov 23 — Nov 301
Round-trip
1 adult, Economy
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Find cheap flights from La Crosse to Charleston with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from La Crosse to Charleston
Cheapest
Best
Last-minute
One-way
Cheapest flights from La Crosse to CharlestonExplore the most affordable flight options available from La Crosse to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 24, 2026.
Explore the most affordable flight options available from La Crosse to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 24, 2026.
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2412:26 pm -
1 stop8h 34m
Sat 11/286:39 am -
1 stop6h 17m
Deal found 10/22![American Airlines logo]()
$747
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:57 am -
1 stop4h 27m
Sun 11/85:05 am -
2 stops7h 48m
Deal found 10/21![American Airlines logo]()
$776
Best flights from La Crosse to CharlestonDiscover carefully curated flight deals from La Crosse to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 24, 2026.
Discover carefully curated flight deals from La Crosse to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 24, 2026.
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/128:04 pm -
1 stop18h 39m
Tue 3/26:26 am -
1 stop13h 28m
Deal found 10/23![American Airlines logo]()
$526
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1112:05 pm -
1 stop11h 12m
Tue 3/24:36 pm -
1 stop8h 46m
Deal found 10/23![American Airlines logo]()
$528
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/2612:29 pm -
1 stop10h 15m
Fri 1/294:17 pm -
1 stop20h 42m
Deal found 10/22![American Airlines logo]()
$528
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/55:34 am -
1 stop8h 53m
Tue 2/97:24 am -
1 stop13h 33m
Deal found 10/19![American Airlines logo]()
$528
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/105:34 am -
2 stops11h 59m
Mon 3/12:17 pm -
2 stops11h 05m
Deal found 10/23![American Airlines logo]()
$539
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/512:29 pm -
2 stops9h 15m
Wed 2/107:24 am -
1 stop5h 35m
Deal found 10/19![American Airlines logo]()
$548
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/612:29 pm -
2 stops8h 10m
Mon 2/82:01 pm -
2 stops6h 56m
Deal found 10/19![American Airlines logo]()
$553
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/612:29 pm -
2 stops9h 29m
Tue 2/911:16 am -
2 stops9h 41m
Deal found 10/19![American Airlines logo]()
$553
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/412:29 pm -
2 stops9h 15m
Wed 2/1011:16 am -
2 stops9h 41m
Deal found 10/19![American Airlines logo]()
$553
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/612:29 pm -
2 stops9h 29m
Wed 2/1011:16 am -
2 stops9h 41m
Deal found 10/19![American Airlines logo]()
$553
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/145:27 am -
2 stops8h 29m
Wed 3/311:06 am -
2 stops8h 48m
Deal found 10/23![American Airlines logo]()
$553
Last-minute flights from La Crosse to CharlestonDiscover last-minute flight deals from La Crosse to Charleston. Data last updated October 24, 2026 and is based on user searches.
Discover last-minute flight deals from La Crosse to Charleston. Data last updated October 24, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:57 am -
1 stop4h 27m
Sun 11/85:05 am -
2 stops7h 48m
Deal found 10/21![American Airlines logo]()
$776
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2412:26 pm -
1 stop8h 34m
Sat 11/286:39 am -
1 stop6h 17m
Deal found 10/22![American Airlines logo]()
$747
One-way flights from La Crosse to CharlestonSearch for one-way flight options from La Crosse to Charleston. Find affordable one-way fares based on user searches. Data last updated October 24, 2026.
Search for one-way flight options from La Crosse to Charleston. Find affordable one-way fares based on user searches. Data last updated October 24, 2026.
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/165:55 am -
1 stop15h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![American Airlines logo]()
$383
Find flight deals from La Crosse to Charleston
Discover tips and strategies to find the most affordable flight options for your journey from La Crosse (LSE) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $458 (American Airlines) |
One-way from | $383 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from La Crosse to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 24, 2026.
Use the filters below to find and compare flights from La Crosse to Charleston that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
La CrosseCharleston
LSE La Crosse - CHS Charleston
LSECHS
La Crosse
Tue 3/2
8:04 pm-3:43 pm
1 stop18h 39m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$383
Quickest round-trip
La CrosseCharleston
LSE La Crosse - CHS Charleston
LSECHS
La Crosse
Wed 12/16
5:55 am-6:45 pm
2 stops11h 50m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$388
La CrosseCharleston
LSE La Crosse - CHS Charleston
LSECHS
La Crosse
Fri 2/12
8:04 pm-3:43 pm
1 stop18h 39m
Charleston
Tue 3/2
6:26 am-6:54 pm
1 stop13h 28m
$526
La CrosseCharleston
LSE La Crosse - CHS Charleston
LSECHS
La Crosse
Thu 2/11
12:05 pm-12:17 am
1 stop11h 12m
Charleston
Tue 3/2
4:36 pm-12:22 am
1 stop8h 46m
$528
La CrosseCharleston
LSE La Crosse - CHS Charleston
LSECHS
La Crosse
Tue 1/26
12:29 pm-11:44 pm
1 stop10h 15m
Charleston
Fri 1/29
4:17 pm-11:59 am
1 stop20h 42m
$528
La CrosseCharleston
LSE La Crosse - CHS Charleston
LSECHS
La Crosse
Fri 2/5
5:34 am-3:27 pm
1 stop8h 53m
Charleston
Tue 2/9
7:24 am-7:57 pm
1 stop13h 33m
$528
La CrosseCharleston
LSE La Crosse - CHS Charleston
LSECHS
La Crosse
Wed 2/10
5:34 am-6:33 pm
2 stops11h 59m
Charleston
Mon 3/1
2:17 pm-12:22 am
2 stops11h 05m
$539
La CrosseCharleston
LSE La Crosse - CHS Charleston
LSECHS
La Crosse
Fri 2/5
12:29 pm-10:44 pm
2 stops9h 15m
Charleston
Wed 2/10
7:24 am-11:59 am
1 stop5h 35m
$548
La CrosseCharleston
LSE La Crosse - CHS Charleston
LSECHS
La Crosse
Sat 2/6
12:29 pm-9:39 pm
2 stops8h 10m
Charleston
Mon 2/8
2:01 pm-7:57 pm
2 stops6h 56m
$553
La CrosseCharleston
LSE La Crosse - CHS Charleston
LSECHS
La Crosse
Sat 2/6
12:29 pm-10:58 pm
2 stops9h 29m
Charleston
Tue 2/9
11:16 am-7:57 pm
2 stops9h 41m
$553
Showing 1-10 of 13 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on La Crosse-Charleston flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on La Crosse-Charleston flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from La Crosse-Charleston flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on La Crosse-Charleston flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for La Crosse-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from La Crosse to Charleston
Have a flexible travel schedule? Discover the best time to fly to Charleston from La Crosse with our price prediction graph.
LSE-CHS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Charleston
Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated October 24, 2026.
Read through reviews of airlines operating flights from La Crosse to Charleston, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.4
Entertainment
6.8
Food
6.4
Comfort
7.1
Crew
7.9
Overall
7.0
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Boarding
7.4
Entertainment
6.8
Food
6.4
Comfort
7.1
Crew
7.9
Overall
7.0
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from La Crosse to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Charleston?
Book flights to Charleston if you plan to visit one of these locationsNorth Charleston
Santee
Summerville
Walterboro
Mount Pleasant
Goose Creek
Edisto Beach
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Other flights to Charleston
Explore flights to Charleston departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 24, 2026.
Complete your trip
Complete your trip to Charleston by adding a car rental and/or hotel reservation to your travel itinerary.
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La Crosse and Charleston flights
Browse other La Crosse and Charleston flight options. Last updated on October 24, 2026.
Other flights from La Crosse
Browse through other flights departing from La Crosse. Flights are based on user searches made on Cheapflights and were last updated on October 24, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from La Crosse to Charleston
Discover the top airline that operate flights from La Crosse to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$299 | Average$580 | FlexibilityNo cancel fee | On-time71% |