$306+ Cheap flights from La Crosse to Charleston (LSE - CHS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/19. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — CHS
Aug 18 — Aug 251
Round-trip
1 adult, Economy
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Find cheap flights from La Crosse to Charleston with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from La Crosse to Charleston
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Best
Last-minute
One-way
Cheapest flights from La Crosse to CharlestonExplore the most affordable flight options available from La Crosse to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 19, 2026.
Explore the most affordable flight options available from La Crosse to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 19, 2026.
This American Airlines deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1912:01 pm
LSE
- CHS
1 stop6h 19m
American Airlines
Sat 8/227:56 pm
CHS
- LSE
1 stop5h 25m
American Airlines
Deal found 7/18![American Airlines logo]()
$306
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2010:51 am
LSE
- CHS
1 stop20h 54m
Multiple Airlines
Sat 8/223:44 pm
CHS
- LSE
1 stop19h 17m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$324
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/1812:01 pm
LSE
- CHS
1 stop6h 37m
American Airlines
Tue 7/2112:44 pm
CHS
- LSE
1 stop5h 43m
American Airlines
Deal found 7/15![American Airlines logo]()
$342
This American Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:04 am
LSE
- CHS
1 stop6h 58m
American Airlines
Tue 11/177:16 am
CHS
- LSE
1 stop5h 37m
American Airlines
Deal found 7/17![American Airlines logo]()
$345
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1912:01 pm
LSE
- CHS
1 stop6h 19m
American Airlines
Sun 8/237:00 am
CHS
- LSE
1 stop5h 23m
American Airlines
Deal found 7/15![American Airlines logo]()
$381
Best flights from La Crosse to CharlestonDiscover carefully curated flight deals from La Crosse to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 19, 2026.
Discover carefully curated flight deals from La Crosse to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 19, 2026.
This American Airlines deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1912:01 pm
LSE
- CHS
2 stops9h 59m
American Airlines
Sat 8/226:15 am
CHS
- LSE
2 stops9h 27m
American Airlines
Deal found 7/18![American Airlines logo]()
$317
This United Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/99:42 am
LSE
- CHS
2 stops23h 39m
United Airlines
Tue 1/127:40 pm
CHS
- LSE
2 stops23h 23m
United Airlines
Deal found 7/17![United Airlines logo]()
$622
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1912:01 pm
LSE
- CHS
1 stop6h 19m
American Airlines
Sun 8/235:05 am
CHS
- LSE
2 stops7h 18m
American Airlines
Deal found 7/15![American Airlines logo]()
$387
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2012:01 pm
LSE
- CHS
2 stops8h 55m
American Airlines
Sat 8/227:00 am
CHS
- LSE
1 stop5h 54m
American Airlines
Deal found 7/15![American Airlines logo]()
$441
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1912:01 pm
LSE
- CHS
1 stop6h 19m
American Airlines
Mon 8/247:00 am
CHS
- LSE
1 stop5h 31m
American Airlines
Deal found 7/15![American Airlines logo]()
$471
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:00 am
LSE
- CHS
1 stop4h 33m
American Airlines
Sun 8/235:05 am
CHS
- LSE
2 stops7h 18m
American Airlines
Deal found 7/15![American Airlines logo]()
$477
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:00 am
LSE
- CHS
2 stops8h 37m
American Airlines
Mon 8/2412:23 pm
CHS
- LSE
1 stop5h 27m
American Airlines
Deal found 7/15![American Airlines logo]()
$477
This American Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/83:14 pm
LSE
- CHS
1 stop7h 45m
American Airlines
Fri 8/144:06 pm
CHS
- LSE
2 stops9h 16m
American Airlines
Deal found 7/16![American Airlines logo]()
$498
This American Airlines deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/75:20 pm
LSE
- CHS
1 stop17h 11m
American Airlines
Wed 8/127:00 am
CHS
- LSE
1 stop18h 22m
American Airlines
Deal found 7/18![American Airlines logo]()
$571
Last-minute flights from La Crosse to CharlestonDiscover last-minute flight deals from La Crosse to Charleston. Data last updated July 19, 2026 and is based on user searches.
Discover last-minute flight deals from La Crosse to Charleston. Data last updated July 19, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/1812:01 pm
LSE
- CHS
1 stop6h 37m
American Airlines
Tue 7/2112:44 pm
CHS
- LSE
1 stop5h 43m
American Airlines
Deal found 7/15![American Airlines logo]()
$342
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:00 am
LSE
- CHS
1 stop4h 33m
American Airlines
Sat 8/227:00 am
CHS
- LSE
1 stop5h 54m
American Airlines
Deal found 7/15![American Airlines logo]()
$396
This American Airlines deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1912:01 pm
LSE
- CHS
1 stop6h 19m
American Airlines
Sat 8/227:56 pm
CHS
- LSE
1 stop5h 25m
American Airlines
Deal found 7/18![American Airlines logo]()
$306
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1912:01 pm
LSE
- CHS
1 stop6h 19m
American Airlines
Sun 8/237:00 am
CHS
- LSE
1 stop5h 23m
American Airlines
Deal found 7/15![American Airlines logo]()
$381
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2010:51 am
LSE
- CHS
1 stop20h 54m
Multiple Airlines
Sat 8/223:44 pm
CHS
- LSE
1 stop19h 17m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$324
One-way flights from La Crosse to CharlestonSearch for one-way flight options from La Crosse to Charleston. Find affordable one-way fares based on user searches. Data last updated July 19, 2026.
Search for one-way flight options from La Crosse to Charleston. Find affordable one-way fares based on user searches. Data last updated July 19, 2026.
This American Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:00 am
LSE
- CHS
1 stop4h 33m
American Airlines
Deal found 7/16![American Airlines logo]()
$489
Find flight deals from La Crosse to Charleston
Discover tips and strategies to find the most affordable flight options for your journey from La Crosse (LSE) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 19, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $306 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from La Crosse to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 19, 2026.
Use the filters below to find and compare flights from La Crosse to Charleston that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
La CrosseCharleston
LSE - CHS
LSECHS
La Crosse
Wed 8/19
12:01 pm-11:00 pm
2 stops9h 59m
Charleston
Sat 8/22
6:15 am-2:42 pm
2 stops9h 27m
$317
La CrosseCharleston
LSE - CHS
LSECHS
La Crosse
Wed 8/19
12:01 pm-7:20 pm
1 stop6h 19m
Charleston
Sun 8/23
5:05 am-11:23 am
2 stops7h 18m
$387
La CrosseCharleston
LSE - CHS
LSECHS
La Crosse
Thu 8/20
12:01 pm-9:56 pm
2 stops8h 55m
Charleston
Sat 8/22
7:00 am-11:54 am
1 stop5h 54m
$441
Quickest round-trip
La CrosseCharleston
LSE - CHS
LSECHS
La Crosse
Wed 8/19
12:01 pm-7:20 pm
1 stop6h 19m
Charleston
Mon 8/24
7:00 am-11:31 am
1 stop5h 31m
$471
La CrosseCharleston
LSE - CHS
LSECHS
La Crosse
Tue 8/18
6:00 am-11:33 am
1 stop4h 33m
Charleston
Sun 8/23
5:05 am-11:23 am
2 stops7h 18m
$477
La CrosseCharleston
LSE - CHS
LSECHS
La Crosse
Tue 8/18
6:00 am-3:37 pm
2 stops8h 37m
Charleston
Mon 8/24
12:23 pm-4:50 pm
1 stop5h 27m
$477
La CrosseCharleston
LSE - CHS
LSECHS
La Crosse
Sat 8/8
3:14 pm-11:59 pm
1 stop7h 45m
Charleston
Fri 8/14
4:06 pm-12:22 am
2 stops9h 16m
$498
La CrosseCharleston
LSE - CHS
LSECHS
La Crosse
Fri 8/7
5:20 pm-11:31 am
1 stop17h 11m
Charleston
Wed 8/12
7:00 am-12:22 am
1 stop18h 22m
$571
La CrosseCharleston
LSE - CHS
LSECHS
La Crosse
Sat 1/9
9:42 am-10:21 am
2 stops23h 39m
Charleston
Tue 1/12
7:40 pm-6:03 pm
2 stops23h 23m
$622
Cheapest one-way
Quickest one-way
La CrosseCharleston
LSE - CHS
LSECHS
La Crosse
Wed 8/5
6:00 am-11:33 am
1 stop4h 33m
$489
Sorted by cheapest first
- Most accurate provider: When it comes to deals on La Crosse-Charleston flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on La Crosse-Charleston flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from La Crosse-Charleston flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on La Crosse-Charleston flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for La Crosse-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from La Crosse to Charleston
Have a flexible travel schedule? Discover the best time to fly to Charleston from La Crosse with our price prediction graph.
LSE-CHS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Charleston
Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated July 19, 2026.
Read through reviews of airlines operating flights from La Crosse to Charleston, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.5
Food
6.4
Comfort
7.2
Overall
7.1
Crew
7.9
Entertainment
6.8
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Boarding
7.5
Food
6.4
Comfort
7.2
Overall
7.1
Crew
7.9
Entertainment
6.8
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from La Crosse to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Charleston?
Book flights to Charleston if you plan to visit one of these locationsNorth Charleston
Santee
Summerville
Walterboro
Isle of Palms
Mount Pleasant
Goose Creek
Edisto Beach
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
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Complete your trip
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Alternative routes for La Crosse to Charleston
See prices for flight routes from nearby airports that may be better suited for you.
Other flights to Charleston
Explore flights to Charleston departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 19, 2026.
Complete your trip
Complete your trip to Charleston by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from La Crosse to Charleston by cabin class
Find flights from La Crosse to Charleston, based on your preferred cabin class, be it economy, premium economy, business, or first class.
La Crosse and Charleston flights
Browse other La Crosse and Charleston flight options. Last updated on July 19, 2026.
Other flights from La Crosse
Browse through other flights departing from La Crosse. Flights are based on user searches made on Cheapflights and were last updated on July 19, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from La Crosse to Charleston
Discover the top airline that operate flights from La Crosse to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 19, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$299 | Average$604 | FlexibilityNo cancel fee | On-time71% |