$387+ Cheap flights from O'Hare Intl (ORD) to Florence, SC (FLO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/9. Fares are subject to change and may not be available on all flights or dates of travel.
ORD — FLO
Oct 6 — Oct 131
Round-trip
1 adult, Economy
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Find cheap flights from O'Hare Intl to Florence with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from O'Hare Intl to FlorenceExplore the most affordable flight options available from O'Hare Intl to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 6, 2026.
Explore the most affordable flight options available from O'Hare Intl to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 6, 2026.
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:29 am -
1 stop6h 40m
Mon 10/122:34 pm -
1 stop6h 17m
Deal found 9/5![American Airlines logo]()
$387
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:29 am -
1 stop5h 49m
Sun 10/45:09 am -
1 stop4h 51m
Deal found 9/1![American Airlines logo]()
$409
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/94:45 pm -
1 stop6h 12m
Sun 10/112:34 pm -
1 stop6h 17m
Deal found 9/5![American Airlines logo]()
$421
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/304:45 pm -
1 stop5h 13m
Sun 10/42:36 pm -
1 stop6h 02m
Deal found 9/1![American Airlines logo]()
$454
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/297:59 am -
1 stop5h 11m
Thu 12/312:35 pm -
1 stop4h 10m
Deal found 9/1![American Airlines logo]()
$455
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/256:47 pm -
1 stop4h 10m
Tue 12/295:09 am -
1 stop6h 53m
Deal found 9/1![American Airlines logo]()
$467
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/256:47 pm -
1 stop4h 10m
Fri 1/15:09 am -
1 stop6h 53m
Deal found 9/1![American Airlines logo]()
$479
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/258:05 am -
1 stop4h 13m
Sun 9/275:09 am -
1 stop4h 51m
Deal found 9/5![American Airlines logo]()
$486
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:29 am -
1 stop5h 49m
Mon 9/211:43 pm -
1 stop4h 55m
Deal found 9/2![American Airlines logo]()
$507
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/125:20 am -
1 stop6h 58m
Sun 9/135:09 am -
1 stop4h 51m
Deal found 9/5![American Airlines logo]()
$530
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/276:47 pm -
1 stop4h 10m
Thu 12/315:09 am -
1 stop5h 11m
Deal found 9/1![American Airlines logo]()
$539
Best flights from O'Hare Intl to FlorenceDiscover carefully curated flight deals from O'Hare Intl to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 6, 2026.
Discover carefully curated flight deals from O'Hare Intl to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 6, 2026.
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:29 am -
1 stop5h 49m
Sun 10/45:09 am -
1 stop4h 51m
Deal found 9/1![American Airlines logo]()
$409
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:29 am -
1 stop6h 40m
Sun 11/15:09 am -
1 stop4h 51m
Deal found 9/4![American Airlines logo]()
$409
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/94:45 pm -
1 stop6h 12m
Sun 10/112:34 pm -
1 stop6h 17m
Deal found 9/5![American Airlines logo]()
$421
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/304:45 pm -
1 stop5h 13m
Sun 10/42:36 pm -
1 stop6h 02m
Deal found 9/1![American Airlines logo]()
$454
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/306:47 pm -
1 stop4h 10m
Thu 12/315:09 am -
1 stop6h 53m
Deal found 9/1![American Airlines logo]()
$455
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/24:45 pm -
1 stop5h 13m
Sun 10/45:09 am -
1 stop4h 51m
Deal found 9/5![American Airlines logo]()
$465
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/258:05 am -
1 stop4h 13m
Sun 9/275:09 am -
1 stop4h 51m
Deal found 9/5![American Airlines logo]()
$486
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:29 am -
1 stop5h 49m
Mon 10/52:34 pm -
1 stop4h 17m
Deal found 9/1![American Airlines logo]()
$557
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/297:59 am -
1 stop5h 11m
Wed 12/305:09 am -
2 stops10h 00m
Deal found 9/1![American Airlines logo]()
$594
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/256:47 pm -
1 stop4h 10m
Sun 1/32:35 pm -
1 stop6h 24m
Deal found 9/1![American Airlines logo]()
$609
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/276:47 pm -
1 stop4h 10m
Sat 1/25:09 am -
1 stop4h 56m
Deal found 9/1![American Airlines logo]()
$646
Last-minute flights from O'Hare Intl to FlorenceDiscover last-minute flight deals from O'Hare Intl to Florence. Data last updated September 6, 2026 and is based on user searches.
Discover last-minute flight deals from O'Hare Intl to Florence. Data last updated September 6, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:20 am -
1 stop6h 58m
Sun 9/135:09 am -
1 stop4h 51m
Deal found 9/5![American Airlines logo]()
$623
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/125:20 am -
1 stop6h 58m
Sun 9/135:09 am -
1 stop4h 51m
Deal found 9/5![American Airlines logo]()
$530
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:29 am -
1 stop5h 49m
Mon 9/211:43 pm -
1 stop4h 55m
Deal found 9/2![American Airlines logo]()
$507
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/258:05 am -
1 stop4h 13m
Sun 9/275:09 am -
1 stop4h 51m
Deal found 9/5![American Airlines logo]()
$486
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/304:45 pm -
1 stop5h 13m
Sun 10/42:36 pm -
1 stop6h 02m
Deal found 9/1![American Airlines logo]()
$454
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:29 am -
1 stop5h 49m
Sun 10/45:09 am -
1 stop4h 51m
Deal found 9/1![American Airlines logo]()
$409
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:29 am -
1 stop5h 49m
Mon 10/52:34 pm -
1 stop4h 17m
Deal found 9/1![American Airlines logo]()
$557
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:29 am -
1 stop6h 40m
Mon 10/122:34 pm -
1 stop6h 17m
Deal found 9/5![American Airlines logo]()
$387
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/94:45 pm -
1 stop6h 12m
Sun 10/112:34 pm -
1 stop6h 17m
Deal found 9/5![American Airlines logo]()
$421
Find flight deals from O'Hare Intl to Florence
Discover tips and strategies to find the most affordable flight options for your journey from O'Hare Intl (ORD) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 6, 2026.
Most accurate provider | Expedia 1 star |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $387 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from O'Hare Intl to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 6, 2026.
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Florence that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Thu 10/1
6:29 am-1:18 pm
1 stop5h 49m
Florence
Sun 10/4
5:09 am-9:00 am
1 stop4h 51m
$409
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Thu 10/29
6:29 am-2:09 pm
1 stop6h 40m
Florence
Sun 11/1
5:09 am-9:00 am
1 stop4h 51m
$409
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Fri 10/9
4:45 pm-11:57 pm
1 stop6h 12m
Florence
Sun 10/11
2:34 pm-7:51 pm
1 stop6h 17m
$421
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Wed 9/30
4:45 pm-10:58 pm
1 stop5h 13m
Florence
Sun 10/4
2:36 pm-7:38 pm
1 stop6h 02m
$454
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Wed 12/30
6:47 pm-11:57 pm
1 stop4h 10m
Florence
Thu 12/31
5:09 am-11:02 am
1 stop6h 53m
$455
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Fri 10/2
4:45 pm-10:58 pm
1 stop5h 13m
Florence
Sun 10/4
5:09 am-9:00 am
1 stop4h 51m
$465
Quickest round-trip
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Fri 9/25
8:05 am-1:18 pm
1 stop4h 13m
Florence
Sun 9/27
5:09 am-9:00 am
1 stop4h 51m
$486
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Thu 10/1
6:29 am-1:18 pm
1 stop5h 49m
Florence
Mon 10/5
2:34 pm-5:51 pm
1 stop4h 17m
$557
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Tue 12/29
7:59 am-2:10 pm
1 stop5h 11m
Florence
Wed 12/30
5:09 am-2:09 pm
2 stops10h 00m
$594
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Fri 12/25
6:47 pm-11:57 pm
1 stop4h 10m
Florence
Sun 1/3
2:35 pm-7:59 pm
1 stop6h 24m
$609
Showing 1-10 of 11 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on Chicago O'Hare Intl Airport-Florence, South Carolina flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Chicago O'Hare Intl Airport-Florence, South Carolina flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Chicago O'Hare Intl Airport-Florence, South Carolina flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Chicago O'Hare Intl Airport-Florence, South Carolina flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Chicago O'Hare Intl Airport-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from O'Hare Intl to Florence
Have a flexible travel schedule? Discover the best time to fly to Florence from O'Hare Intl with our price prediction graph.
ORD-FLO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from O'Hare Intl to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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