$411+ Cheap flights from O'Hare Intl (ORD) to Florence, SC (FLO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/21. Fares are subject to change and may not be available on all flights or dates of travel.
ORD — FLO
Nov 23 — Nov 301
Round-trip
1 adult, Economy
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Find cheap flights from O'Hare Intl to Florence with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from O'Hare Intl to Florence
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Last-minute
Cheapest flights from O'Hare Intl to FlorenceExplore the most affordable flight options available from O'Hare Intl to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 24, 2026.
Explore the most affordable flight options available from O'Hare Intl to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 24, 2026.
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/214:58 pm -
1 stop5h 56m
Tue 11/245:09 am -
1 stop6h 51m
Deal found 10/20![American Airlines logo]()
$411
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/187:59 am -
1 stop5h 11m
Wed 12/232:35 pm -
1 stop4h 10m
Deal found 10/23![American Airlines logo]()
$426
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/119:00 am -
1 stop5h 09m
Sat 11/146:24 am -
1 stop6h 55m
Deal found 10/20![American Airlines logo]()
$473
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/199:00 am -
1 stop4h 09m
Mon 11/235:09 am -
1 stop4h 50m
Deal found 10/21![American Airlines logo]()
$490
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/64:40 pm -
1 stop6h 16m
Tue 11/106:24 am -
1 stop6h 55m
Deal found 10/22![American Airlines logo]()
$506
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:41 am -
1 stop6h 29m
Mon 11/163:37 pm -
1 stop4h 59m
Deal found 10/22![American Airlines logo]()
$539
Best flights from O'Hare Intl to FlorenceDiscover carefully curated flight deals from O'Hare Intl to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 24, 2026.
Discover carefully curated flight deals from O'Hare Intl to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 24, 2026.
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/189:00 am -
1 stop5h 09m
Sat 11/215:09 am -
1 stop4h 51m
Deal found 10/24![American Airlines logo]()
$473
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/78:05 am -
1 stop6h 04m
Sat 11/143:37 pm -
1 stop5h 34m
Deal found 10/23![American Airlines logo]()
$473
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/119:00 am -
1 stop5h 09m
Sat 11/146:24 am -
1 stop6h 55m
Deal found 10/20![American Airlines logo]()
$473
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/49:00 am -
1 stop5h 09m
Sun 11/85:09 am -
1 stop4h 51m
Deal found 10/20![American Airlines logo]()
$506
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/64:40 pm -
1 stop6h 16m
Tue 11/106:24 am -
1 stop6h 55m
Deal found 10/22![American Airlines logo]()
$506
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/124:40 pm -
1 stop6h 16m
Sun 11/155:09 am -
1 stop6h 53m
Deal found 10/20![American Airlines logo]()
$539
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/104:40 pm -
1 stop5h 19m
Sat 11/146:24 am -
2 stops7h 35m
Deal found 10/20![American Airlines logo]()
$581
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected ” under the list of providers to see comparable flight deals.
Sat 11/142:55 pm -
2 stops7h 04m
Tue 11/176:24 am -
1 stop5h 36m
Deal found 10/20![American Airlines logo]()
$581
Last-minute flights from O'Hare Intl to FlorenceDiscover last-minute flight deals from O'Hare Intl to Florence. Data last updated October 24, 2026 and is based on user searches.
Discover last-minute flight deals from O'Hare Intl to Florence. Data last updated October 24, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/64:40 pm -
1 stop6h 16m
Tue 11/106:24 am -
1 stop6h 55m
Deal found 10/22![American Airlines logo]()
$506
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:41 am -
1 stop6h 29m
Mon 11/163:37 pm -
1 stop4h 59m
Deal found 10/22![American Airlines logo]()
$539
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/119:00 am -
1 stop5h 09m
Sat 11/146:24 am -
1 stop6h 55m
Deal found 10/20![American Airlines logo]()
$473
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/199:00 am -
1 stop4h 09m
Mon 11/235:09 am -
1 stop4h 50m
Deal found 10/21![American Airlines logo]()
$490
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/214:58 pm -
1 stop5h 56m
Tue 11/245:09 am -
1 stop6h 51m
Deal found 10/20![American Airlines logo]()
$411
Find flight deals from O'Hare Intl to Florence
Discover tips and strategies to find the most affordable flight options for your journey from O'Hare Intl (ORD) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 24, 2026.
Most accurate provider | Expedia 1 star |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $411 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from O'Hare Intl to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 24, 2026.
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Florence that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Wed 11/18
9:00 am-3:09 pm
1 stop5h 09m
Florence
Sat 11/21
5:09 am-9:00 am
1 stop4h 51m
$473
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Sat 11/7
8:05 am-3:09 pm
1 stop6h 04m
Florence
Sat 11/14
3:37 pm-8:11 pm
1 stop5h 34m
$473
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Wed 11/11
9:00 am-3:09 pm
1 stop5h 09m
Florence
Sat 11/14
6:24 am-12:19 pm
1 stop6h 55m
$473
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Wed 11/4
9:00 am-3:09 pm
1 stop5h 09m
Florence
Sun 11/8
5:09 am-9:00 am
1 stop4h 51m
$506
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Fri 11/6
4:40 pm-11:56 pm
1 stop6h 16m
Florence
Tue 11/10
6:24 am-12:19 pm
1 stop6h 55m
$506
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Thu 11/12
4:40 pm-11:56 pm
1 stop6h 16m
Florence
Sun 11/15
5:09 am-11:02 am
1 stop6h 53m
$539
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Tue 11/10
4:40 pm-10:59 pm
1 stop5h 19m
Florence
Sat 11/14
6:24 am-12:59 pm
2 stops7h 35m
$581
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Sat 11/14
2:55 pm-10:59 pm
2 stops7h 04m
Florence
Tue 11/17
6:24 am-11:00 am
1 stop5h 36m
$581
Sorted by cheapest first
- Most accurate provider: When it comes to deals on Chicago O'Hare Intl Airport-Florence, South Carolina flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Chicago O'Hare Intl Airport-Florence, South Carolina flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Chicago O'Hare Intl Airport-Florence, South Carolina flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Chicago O'Hare Intl Airport-Florence, South Carolina flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Chicago O'Hare Intl Airport-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from O'Hare Intl to Florence
Have a flexible travel schedule? Discover the best time to fly to Florence from O'Hare Intl with our price prediction graph.
ORD-FLO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from O'Hare Intl to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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