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Florence

$173+ Cheap flights from O'Hare Intl (ORD) to Florence, SC (FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/11. Fares are subject to change and may not be available on all flights or dates of travel.
ORD — FLO
Aug 12 — Aug 191
Wed 8/12
Wed 8/19
1 adult, Economy
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Cheap flight deals from O'Hare Intl to Florence

Cheapest flights from O'Hare Intl to Florence
Explore the most affordable flight options available from O'Hare Intl to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 13, 2026.

This American Airlines deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:49 am
ORD
-
FLO
1 stop7h 07m
American Airlines
Wed 8/196:22 am
FLO
-
ORD
1 stop5h 29m
American Airlines
Deal found 7/9$345
This American Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:30 am
ORD
-
FLO
1 stop6h 26m
American Airlines
Mon 8/313:22 pm
FLO
-
ORD
1 stop5h 24m
American Airlines
Deal found 7/10$346
This American Airlines deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/84:53 pm
ORD
-
FLO
1 stop5h 06m
American Airlines
Sat 8/156:22 am
FLO
-
ORD
1 stop5h 29m
American Airlines
Deal found 7/11$390
This American Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/97:30 am
ORD
-
FLO
1 stop5h 42m
American Airlines
Sun 8/165:05 am
FLO
-
ORD
1 stop5h 00m
American Airlines
Deal found 7/10$413
This American Airlines deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/266:30 am
ORD
-
FLO
1 stop6h 40m
American Airlines
Tue 7/285:17 am
FLO
-
ORD
1 stop4h 45m
American Airlines
Deal found 7/9$458
This American Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/166:47 pm
ORD
-
FLO
1 stop3h 50m
American Airlines
Sun 7/195:17 am
FLO
-
ORD
1 stop4h 45m
American Airlines
Deal found 7/10$537
This American Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:40 pm
ORD
-
FLO
1 stop4h 23m
American Airlines
Sat 11/285:15 am
FLO
-
ORD
1 stop6h 50m
American Airlines
Deal found 7/10$621
This American Airlines deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:49 am
ORD
-
FLO
1 stop7h 07m
American Airlines
Mon 8/176:22 am
FLO
-
ORD
2 stops6h 50m
American Airlines
Deal found 7/9$639
This American Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/106:30 am
ORD
-
FLO
1 stop6h 40m
American Airlines
Sun 7/122:35 pm
FLO
-
ORD
1 stop6h 16m
American Airlines
Deal found 7/8$649
This American Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:45 am
ORD
-
FLO
1 stop7h 09m
American Airlines
Mon 10/195:09 am
FLO
-
ORD
2 stops7h 27m
American Airlines
Deal found 7/8$676

Find flight deals from O'Hare Intl to Florence

Discover tips and strategies to find the most affordable flight options for your journey from O'Hare Intl (ORD) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 13, 2026.

Most accurate provider

Expedia
1 star

Most trusted provider

Expedia
3 stars

Round-trip from

$345
(American Airlines)

One-way from

$173
(American Airlines)
Provider with most accurate pricing for Chicago O'Hare Intl-Florence flight deals.
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Provider most trusted by Cheapflights users for Chicago O'Hare Intl-Florence flights.
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From Chicago O'Hare Intl to Florence
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One-way flight from Chicago O'Hare Intl to Florence
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Cheapflights Fare Finder

 
Customize your flight search to find flights from O'Hare Intl to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 13, 2026.
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Tue 8/18

4:53 pm-10:59 pm

1 stop5h 06m

Florence

Tue 8/25

6:22 am-10:51 am

1 stop5h 29m

$345

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Thu 9/24

5:20 am-1:18 pm

1 stop6h 58m

Florence

Sat 10/3

6:24 am-10:45 am

1 stop5h 21m

$345

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Tue 8/11

8:54 am-2:56 pm

1 stop5h 02m

Florence

Tue 8/18

3:22 pm-9:57 pm

1 stop7h 35m

$345

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Wed 9/23

5:20 am-1:18 pm

1 stop6h 58m

Florence

Sat 10/3

6:24 am-10:45 am

1 stop5h 21m

$345

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Tue 10/13

6:45 am-2:54 pm

1 stop7h 09m

Florence

Mon 10/19

2:34 pm-5:51 pm

1 stop4h 17m

$537

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Wed 8/12

8:54 am-2:56 pm

1 stop5h 02m

Florence

Wed 8/19

6:22 am-12:54 pm

2 stops7h 32m

$574

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Thu 8/13

6:49 am-2:56 pm

1 stop7h 07m

Florence

Mon 8/17

6:22 am-12:12 pm

2 stops6h 50m

$639
Cheapest one-way
Quickest one-way

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Tue 8/11

5:49 pm-10:59 pm

1 stop4h 10m

$173

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 8/22

7:30 am-2:56 pm

1 stop6h 26m

$173

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Wed 8/12

8:54 am-2:56 pm

1 stop5h 02m

$173

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/12

Showing 1-10 of 12 resultsSorted by cheapest first
1
2
  • Most accurate provider: When it comes to deals on Chicago O'Hare Intl Airport-Florence, South Carolina flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Chicago O'Hare Intl Airport-Florence, South Carolina flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Chicago O'Hare Intl Airport-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Chicago O'Hare Intl Airport-Florence, South Carolina flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Chicago O'Hare Intl Airport-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from O'Hare Intl to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from O'Hare Intl with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from O'Hare Intl to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Chicago O'Hare Intl?

    Located just 2.3 mi from the city center, Florence is the airport most travelers will use when flying to Florence from Chicago O'Hare Intl. Booking flights from Chicago O'Hare Intl to Florence (FLO) should be relatively easy as there are 0 daily inbound flights from Chicago O'Hare Intl from 0 different airlines.

  • How long is the flight from Chicago O'Hare Intl Airport to Florence, South Carolina?

    Airlines like American Airlines fly from Chicago O'Hare Intl Airport to Florence, South Carolina in about 5h 06m. The time it takes to get you to your destination can typically vary by up to . The distance from Chicago O'Hare Intl Airport to Florence, South Carolina is about 697 mi.

  • Can I find deals for flights from O'Hare Intl to Florence that include hotel bookings?

    Yes. In addition to deals on O'Hare Intl to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from O'Hare Intl to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from O'Hare Intl to Florence.

  • Can I find deals for business class flights from O'Hare Intl to Florence?

    Yes. Cheapflights offers flight deals from O'Hare Intl to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

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