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Florence

$170+ Cheap flights from O'Hare Intl (ORD) to Florence, SC (FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/4. Fares are subject to change and may not be available on all flights or dates of travel.
ORD — FLO
May 24 — May 311
Sun 5/24
Sun 5/31
1 adult, Economy
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Cheap flight deals from O'Hare Intl to Florence

Cheapest flights from O'Hare Intl to Florence
Explore the most affordable flight options available from O'Hare Intl to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2026.

This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/201:54 pm
ORD
-
FLO
1 stop6h 53m
American Airlines
Tue 5/265:05 am
FLO
-
ORD
1 stop4h 57m
American Airlines
Deal found 4/19$279
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/83:26 pm
ORD
-
FLO
1 stop5h 21m
American Airlines
Wed 5/134:16 pm
FLO
-
ORD
1 stop4h 06m
American Airlines
Deal found 4/23$339
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:17 pm
ORD
-
FLO
1 stop4h 30m
American Airlines
Sat 4/255:20 am
FLO
-
ORD
1 stop4h 10m
American Airlines
Deal found 4/19$359
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/247:58 am
ORD
-
FLO
1 stop5h 12m
American Airlines
Sat 6/272:35 pm
FLO
-
ORD
1 stop4h 15m
American Airlines
Deal found 4/21$369
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/247:58 am
ORD
-
FLO
1 stop5h 12m
American Airlines
Wed 7/12:35 pm
FLO
-
ORD
2 stops9h 45m
American Airlines
Deal found 4/21$374
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/207:58 am
ORD
-
FLO
1 stop5h 12m
American Airlines
Tue 6/305:05 am
FLO
-
ORD
1 stop6h 44m
American Airlines
Deal found 4/21$399
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/204:45 pm
ORD
-
FLO
1 stop4h 15m
American Airlines
Wed 7/15:05 am
FLO
-
ORD
2 stops8h 52m
American Airlines
Deal found 4/21$404
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/208:48 am
ORD
-
FLO
1 stop4h 22m
American Airlines
Fri 7/35:17 am
FLO
-
ORD
1 stop4h 45m
American Airlines
Deal found 4/21$429
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/226:55 am
ORD
-
FLO
1 stop6h 15m
American Airlines
Tue 6/305:05 am
FLO
-
ORD
1 stop6h 44m
American Airlines
Deal found 4/21$436

Find flight deals from O'Hare Intl to Florence

Discover tips and strategies to find the most affordable flight options for your journey from O'Hare Intl (ORD) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 24, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$279
(American Airlines)

One-way from

$170
(American Airlines)
Provider with most accurate pricing for Chicago O'Hare Intl-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Chicago O'Hare Intl-Florence flights.
Search Deals
From Chicago O'Hare Intl to Florence
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One-way flight from Chicago O'Hare Intl to Florence
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Cheapflights Fare Finder

 
Customize your flight search to find flights from O'Hare Intl to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2026.
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Wed 5/20

1:54 pm-9:47 pm

1 stop6h 53m

Florence

Tue 5/26

5:05 am-9:02 am

1 stop4h 57m

$279
Quickest round-trip

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Fri 5/8

3:26 pm-9:47 pm

1 stop5h 21m

Florence

Wed 5/13

4:16 pm-7:22 pm

1 stop4h 06m

$339

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Wed 6/24

7:58 am-2:10 pm

1 stop5h 12m

Florence

Wed 7/1

2:35 pm-7:45 pm

1 stop6h 10m

$369

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Wed 6/24

7:58 am-2:10 pm

1 stop5h 12m

Florence

Tue 6/30

5:05 am-10:49 am

1 stop6h 44m

$369

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 6/20

4:45 pm-10:00 pm

1 stop4h 15m

Florence

Sun 6/28

2:35 pm-7:45 pm

1 stop6h 10m

$429

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Mon 6/22

6:55 am-2:10 pm

1 stop6h 15m

Florence

Tue 6/30

5:05 am-10:49 am

1 stop6h 44m

$436

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Mon 6/22

6:55 am-2:10 pm

1 stop6h 15m

Florence

Sun 6/28

5:05 am-10:49 am

1 stop6h 44m

$466

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Fri 6/26

6:00 am-2:10 pm

2 stops7h 10m

Florence

Wed 7/1

2:35 pm-9:29 pm

2 stops7h 54m

$509
Cheapest one-way

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Thu 6/4

6:55 am-2:10 pm

1 stop6h 15m

$170
Quickest one-way

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Fri 5/1

4:17 pm-9:47 pm

1 stop4h 30m

$170

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/21

Sorted by cheapest first

Compare providers for flights from O'Hare Intl to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from O'Hare Intl to Florence in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Chicago O'Hare Intl Airport-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Chicago O'Hare Intl Airport-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Chicago O'Hare Intl Airport-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Chicago O'Hare Intl Airport-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Chicago O'Hare Intl Airport-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from O'Hare Intl to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from O'Hare Intl with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from O'Hare Intl to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Chicago O'Hare Intl?

    Located just 2.3 mi from the city center, Florence is the airport most travelers will use when flying to Florence from Chicago O'Hare Intl. Booking flights from Chicago O'Hare Intl to Florence (FLO) should be relatively easy as there are 0 daily inbound flights from Chicago O'Hare Intl from 0 different airlines.

  • How long is the flight from Chicago O'Hare Intl Airport to Florence, South Carolina?

    Airlines like American Airlines fly from Chicago O'Hare Intl Airport to Florence, South Carolina in about 6h 53m. The time it takes to get you to your destination can typically vary by up to . The distance from Chicago O'Hare Intl Airport to Florence, South Carolina is about 697 mi.

  • Can I find deals for flights from O'Hare Intl to Florence that include hotel bookings?

    Yes. In addition to deals on O'Hare Intl to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from O'Hare Intl to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from O'Hare Intl to Florence.

  • Can I find deals for business class flights from O'Hare Intl to Florence?

    Yes. Cheapflights offers flight deals from O'Hare Intl to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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