$80+ Cheap flights from O'Hare Intl (ORD) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/12. Fares are subject to change and may not be available on all flights or dates of travel.
ORD — CHS
May 24 — May 311
Round-trip
1 adult, Economy
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Cheapest flights from O'Hare Intl to South CarolinaExplore the most affordable flight options available from O'Hare Intl to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2026.
Explore the most affordable flight options available from O'Hare Intl to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2412:37 pm
ORD
- CLT
Nonstop2h 08m
Multiple Airlines
Wed 4/2912:50 pm
CLT
- ORD
1 stop12h 34m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$148
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2412:37 pm
ORD
- CLT
Nonstop2h 08m
Multiple Airlines
Mon 4/279:54 pm
CLT
- ORD
1 stop24h 23m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$150
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2312:16 pm
ORD
- CLT
Nonstop2h 08m
Multiple Airlines
Tue 4/2812:50 pm
CLT
- ORD
1 stop9h 27m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$152
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2312:16 pm
ORD
- CLT
Nonstop2h 08m
Multiple Airlines
Thu 4/3012:50 pm
CLT
- ORD
1 stop9h 27m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$154
This Expedia deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/112:37 pm
ORD
- CLT
Nonstop2h 08m
Frontier
Mon 5/48:09 pm
CLT
- ORD
1 stop28h 04m
Frontier
Deal found 4/19![Frontier logo]()
$155
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2412:37 pm
ORD
- CLT
Nonstop2h 08m
Multiple Airlines
Tue 4/2812:50 pm
CLT
- ORD
1 stop9h 27m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$157
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2712:37 pm
ORD
- CLT
Nonstop2h 08m
Multiple Airlines
Wed 4/2912:50 pm
CLT
- ORD
1 stop12h 34m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$159
This Expedia deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/114:05 pm
ORD
- CLT
1 stop19h 00m
Frontier
Sat 5/161:00 pm
CLT
- ORD
1 stop6h 44m
Frontier
Deal found 4/22![Frontier logo]()
$160
This Frontier deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2312:16 pm
ORD
- CLT
Nonstop2h 08m
Frontier
Fri 4/244:40 pm
CLT
- ORD
Nonstop2h 34m
Frontier
Deal found 4/20![Frontier logo]()
$161
This Priceline deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/195:05 am
ORD
- CLT
1 stop8h 06m
Multiple Airlines
Wed 5/2012:13 pm
CLT
- ORD
1 stop11h 33m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$162
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/201:12 pm
ORD
- CLT
Nonstop2h 10m
Multiple Airlines
Wed 4/2912:50 pm
CLT
- ORD
1 stop12h 34m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$163
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/145:30 am
ORD
- AGS
1 stop4h 27m
Delta
Wed 8/1911:35 am
AGS
- ORD
1 stop6h 10m
Delta
Deal found 4/20![Delta logo]()
$197
Best flights from O'Hare Intl to South CarolinaDiscover carefully curated flight deals from O'Hare Intl to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 24, 2026.
Discover carefully curated flight deals from O'Hare Intl to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 24, 2026.
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/192:00 pm
ORD
- CLT
Nonstop2h 11m
United Airlines
Wed 5/207:43 pm
CLT
- ORD
1 stop5h 01m
United Airlines
Deal found 4/22![United Airlines logo]()
$177
This Delta deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/205:30 am
ORD
- AGS
1 stop4h 27m
Delta
Mon 8/247:00 am
AGS
- ORD
1 stop6h 08m
Delta
Deal found 4/19![Delta logo]()
$197
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/45:00 am
ORD
- AGS
1 stop4h 34m
American Airlines
Fri 5/85:08 pm
AGS
- ORD
1 stop6h 12m
American Airlines
Deal found 4/19![American Airlines logo]()
$245
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1211:55 am
ORD
- GSP
2 stops8h 45m
Southwest
Thu 5/146:25 am
GSP
- ORD
1 stop7h 25m
Southwest
Deal found 4/22![Southwest logo]()
$253
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:15 pm
ORD
- CLT
Nonstop2h 14m
United Airlines
Sat 5/309:55 am
CLT
- ORD
Nonstop2h 15m
United Airlines
Deal found 4/21![United Airlines logo]()
$184
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/155:30 am
ORD
- AGS
1 stop4h 19m
Delta
Fri 6/198:24 pm
AGS
- ORD
1 stop4h 35m
Delta
Deal found 4/20![Delta logo]()
$218
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/247:00 am
ORD
- CLT
1 stop4h 14m
Delta
Wed 5/271:05 pm
CLT
- ORD
1 stop4h 24m
Delta
Deal found 4/21![Delta logo]()
$233
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/157:22 am
ORD
- CLT
Nonstop2h 23m
United Airlines
Wed 5/207:43 pm
CLT
- ORD
1 stop5h 01m
United Airlines
Deal found 4/23![United Airlines logo]()
$238
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/201:54 pm
ORD
- FLO
1 stop6h 53m
American Airlines
Tue 5/265:05 am
FLO
- ORD
1 stop4h 57m
American Airlines
Deal found 4/19![American Airlines logo]()
$279
This United Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:15 pm
ORD
- CLT
Nonstop2h 14m
United Airlines
Tue 6/98:05 am
CLT
- ORD
Nonstop2h 17m
United Airlines
Deal found 4/19![United Airlines logo]()
$259
This Delta deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:30 am
ORD
- CLT
1 stop4h 41m
Delta
Tue 5/265:35 am
CLT
- ORD
1 stop5h 41m
Delta
Deal found 4/19![Delta logo]()
$279
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/195:00 am
ORD
- AGS
1 stop6h 25m
American Airlines
Thu 5/216:27 pm
AGS
- ORD
1 stop6h 32m
American Airlines
Deal found 4/22![American Airlines logo]()
$311
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/209:30 pm
ORD
- CLT
Nonstop2h 11m
United Airlines
Sun 5/247:44 pm
CLT
- ORD
1 stop4h 42m
United Airlines
Deal found 4/23![United Airlines logo]()
$262
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/202:40 pm
ORD
- SAV
1 stop4h 20m
Southwest
Wed 5/276:40 am
SAV
- ORD
1 stop7h 10m
Southwest
Deal found 4/20![Southwest logo]()
$351
This Delta deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/111:35 am
ORD
- GSP
1 stop7h 49m
Delta
Sun 7/57:10 am
GSP
- ORD
1 stop4h 35m
Delta
Deal found 4/19![Delta logo]()
$282
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/176:10 pm
ORD
- GSP
Nonstop2h 07m
United Airlines
Wed 6/247:40 pm
GSP
- ORD
1 stop4h 46m
United Airlines
Deal found 4/22![United Airlines logo]()
$265
This Southwest deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:00 am
ORD
- CHS
2 stops12h 10m
Southwest
Mon 5/116:00 am
CHS
- ORD
2 stops10h 30m
Southwest
Deal found 4/19![Southwest logo]()
$355
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/83:26 pm
ORD
- FLO
1 stop5h 21m
American Airlines
Wed 5/134:16 pm
FLO
- ORD
1 stop4h 06m
American Airlines
Deal found 4/23![American Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/211:35 am
ORD
- GSP
1 stop7h 47m
Delta
Tue 7/73:35 pm
GSP
- ORD
1 stop6h 21m
Delta
Deal found 4/19![Delta logo]()
$282
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/157:50 pm
ORD
- GSP
Nonstop2h 08m
United Airlines
Wed 5/205:45 pm
GSP
- ORD
Nonstop2h 20m
United Airlines
Deal found 4/21![United Airlines logo]()
$269
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/278:59 pm
ORD
- GSP
Nonstop1h 59m
American Airlines
Sun 7/56:44 pm
GSP
- ORD
Nonstop2h 31m
American Airlines
Deal found 4/24![American Airlines logo]()
$348
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:06 pm
ORD
- CAE
1 stop4h 38m
Delta
Mon 5/256:40 am
CAE
- ORD
1 stop4h 36m
Delta
Deal found 4/22![Delta logo]()
$289
This United Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/308:40 am
ORD
- CLT
1 stop4h 31m
United Airlines
Tue 6/28:05 am
CLT
- ORD
Nonstop2h 17m
United Airlines
Deal found 4/19![United Airlines logo]()
$269
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:06 pm
ORD
- CAE
1 stop4h 38m
Delta
Wed 5/277:01 am
CAE
- ORD
1 stop7h 15m
Delta
Deal found 4/20![Delta logo]()
$289
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/166:00 am
ORD
- SAV
2 stops11h 55m
Southwest
Sat 5/237:40 am
SAV
- ORD
2 stops8h 50m
Southwest
Deal found 4/20![Southwest logo]()
$442
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/247:58 am
ORD
- FLO
1 stop5h 12m
American Airlines
Wed 7/12:35 pm
FLO
- ORD
1 stop6h 10m
American Airlines
Deal found 4/21![American Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/127:05 am
ORD
- CAE
1 stop7h 20m
Delta
Sun 6/147:39 pm
CAE
- ORD
1 stop5h 20m
Delta
Deal found 4/20![Delta logo]()
$289
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/206:15 pm
ORD
- CLT
Nonstop2h 14m
United Airlines
Sun 6/286:15 am
CLT
- ORD
Nonstop2h 24m
United Airlines
Deal found 4/20![United Airlines logo]()
$289
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/247:58 am
ORD
- FLO
1 stop5h 12m
American Airlines
Tue 6/305:05 am
FLO
- ORD
1 stop6h 44m
American Airlines
Deal found 4/21![American Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:10 am
ORD
- GSP
1 stop6h 39m
Delta
Sun 10/187:15 am
GSP
- ORD
1 stop4h 13m
Delta
Deal found 4/20![Delta logo]()
$289
Last-minute flights from O'Hare Intl to South CarolinaDiscover last-minute flight deals from O'Hare Intl to South Carolina. Data last updated April 24, 2026 and is based on user searches.
Discover last-minute flight deals from O'Hare Intl to South Carolina. Data last updated April 24, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2312:16 pm
ORD
- CLT
Nonstop2h 08m
Multiple Airlines
Tue 4/2812:50 pm
CLT
- ORD
1 stop9h 27m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$152
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2312:16 pm
ORD
- CLT
Nonstop2h 08m
Multiple Airlines
Thu 4/3012:50 pm
CLT
- ORD
1 stop9h 27m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$154
This Frontier deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2312:16 pm
ORD
- CLT
Nonstop2h 08m
Frontier
Fri 4/244:40 pm
CLT
- ORD
Nonstop2h 34m
Frontier
Deal found 4/20![Frontier logo]()
$161
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2412:37 pm
ORD
- CLT
Nonstop2h 08m
Multiple Airlines
Wed 4/2912:50 pm
CLT
- ORD
1 stop12h 34m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$148
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2412:37 pm
ORD
- CLT
Nonstop2h 08m
Multiple Airlines
Mon 4/279:54 pm
CLT
- ORD
1 stop24h 23m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$150
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2412:37 pm
ORD
- CLT
Nonstop2h 08m
Multiple Airlines
Tue 4/2812:50 pm
CLT
- ORD
1 stop9h 27m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$157
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2712:37 pm
ORD
- CLT
Nonstop2h 08m
Multiple Airlines
Wed 4/2912:50 pm
CLT
- ORD
1 stop12h 34m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$159
This Expedia deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/112:37 pm
ORD
- CLT
Nonstop2h 08m
Frontier
Mon 5/48:09 pm
CLT
- ORD
1 stop28h 04m
Frontier
Deal found 4/19![Frontier logo]()
$155
This Expedia deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/114:05 pm
ORD
- CLT
1 stop19h 00m
Frontier
Sat 5/161:00 pm
CLT
- ORD
1 stop6h 44m
Frontier
Deal found 4/22![Frontier logo]()
$160
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:00 am
ORD
- AGS
1 stop4h 34m
American Airlines
Mon 5/188:23 pm
AGS
- ORD
1 stop4h 31m
American Airlines
Deal found 4/20![American Airlines logo]()
$197
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/132:40 pm
ORD
- GSP
1 stop6h 00m
Southwest
Sat 5/166:25 am
GSP
- ORD
1 stop10h 05m
Southwest
Deal found 4/21![Southwest logo]()
$244
This Priceline deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/195:05 am
ORD
- CLT
1 stop8h 06m
Multiple Airlines
Wed 5/2012:13 pm
CLT
- ORD
1 stop11h 33m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$162
One-way flights from O'Hare Intl to South CarolinaSearch for one-way flight options from O'Hare Intl to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 24, 2026.
Search for one-way flight options from O'Hare Intl to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 24, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/123:55 pm
ORD
- CLT
1 stop23h 48m
Frontier
Deal found 4/22![Frontier logo]()
$80
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/239:37 pm
ORD
- CLT
1 stop19h 41m
Frontier
Deal found 4/20![Frontier logo]()
$83
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/122:00 pm
ORD
- CLT
Nonstop2h 11m
United Airlines
Deal found 4/23![United Airlines logo]()
$84
This Mytrip deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/27:15 pm
ORD
- CLT
1 stop12h 55m
Spirit Airlines
Deal found 4/23![Spirit Airlines logo]()
$86
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/195:05 am
ORD
- CLT
1 stop8h 06m
Spirit Airlines
Deal found 4/22![Spirit Airlines logo]()
$88
This Frontier deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/289:20 am
ORD
- CLT
1 stop7h 35m
Frontier
Deal found 4/21![Frontier logo]()
$90
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/133:55 pm
ORD
- CLT
1 stop25h 57m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$91
This Gotogate deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:05 am
ORD
- CLT
1 stop8h 06m
Spirit Airlines
Deal found 4/21![Spirit Airlines logo]()
$92
This Cheapflightsfares deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:05 am
ORD
- CLT
1 stop8h 06m
Spirit Airlines
Deal found 4/19![Spirit Airlines logo]()
$93
This Southwest deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/192:40 pm
ORD
- CLT
1 stop6h 10m
Southwest
Deal found 4/19![Southwest logo]()
$94
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/38:05 am
ORD
- MYR
1 stop11h 31m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$95
This Super.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/85:30 pm
ORD
- CLT
1 stop22h 13m
Frontier
Deal found 4/21![Frontier logo]()
$95
Find flight deals from O'Hare Intl to South Carolina
Keep the following information in mind while searching for O'Hare Intl to South Carolina flight deals. Data was last updated April 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $154 (Trip.com) |
One-way from | $80 (Kiwi.com) |
Popular in | December |
Cheapest in | August |
Average price | $376 |
Good round-trip deal | $319 or less |
Good one-way deal | $186 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from O'Hare Intl to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2026.
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ChicagoCharlotte
ORD - CLT
ORDCLT
Chicago O'Hare Intl
Tue 5/19
2:00 pm-5:11 pm
Nonstop2h 11m
Charlotte Douglas
Wed 5/20
7:43 pm-11:44 pm
1 stop5h 01m
$177
ChicagoCharlotte
ORD - CLT
ORDCLT
Chicago O'Hare Intl
Tue 5/26
6:15 pm-9:29 pm
Nonstop2h 14m
Charlotte Douglas
Sat 5/30
9:55 am-11:10 am
Nonstop2h 15m
$184
ChicagoAugusta
ORD - AGS
ORDAGS
Chicago O'Hare Intl
Thu 8/20
5:30 am-10:57 am
1 stop4h 27m
Augusta Bush Field
Mon 8/24
7:00 am-12:08 pm
1 stop6h 08m
$197
ChicagoAugusta
ORD - AGS
ORDAGS
Chicago O'Hare Intl
Mon 6/15
5:30 am-10:49 am
1 stop4h 19m
Augusta Bush Field
Fri 6/19
8:24 pm-11:59 pm
1 stop4h 35m
$218
ChicagoCharlotte
ORD - CLT
ORDCLT
Chicago O'Hare Intl
Sun 5/24
7:00 am-12:14 pm
1 stop4h 14m
Charlotte Douglas
Wed 5/27
1:05 pm-4:29 pm
1 stop4h 24m
$233
ChicagoCharlotte
ORD - CLT
ORDCLT
Chicago O'Hare Intl
Fri 5/15
7:22 am-10:45 am
Nonstop2h 23m
Charlotte Douglas
Wed 5/20
7:43 pm-11:44 pm
1 stop5h 01m
$238
ChicagoAugusta
ORD - AGS
ORDAGS
Chicago O'Hare Intl
Mon 5/4
5:00 am-10:34 am
1 stop4h 34m
Augusta Bush Field
Fri 5/8
5:08 pm-10:20 pm
1 stop6h 12m
$245
ChicagoGreenville
ORD - GSP
ORDGSP
Chicago O'Hare Intl
Tue 5/12
11:55 am-9:40 pm
2 stops8h 45m
Greenville
Thu 5/14
6:25 am-12:50 pm
1 stop7h 25m
$253
ChicagoCharlotte
ORD - CLT
ORDCLT
Chicago O'Hare Intl
Tue 6/2
6:15 pm-9:29 pm
Nonstop2h 14m
Charlotte Douglas
Tue 6/9
8:05 am-9:22 am
Nonstop2h 17m
$259
ChicagoCharlotte
ORD - CLT
ORDCLT
Chicago O'Hare Intl
Wed 5/20
9:30 pm-12:41 am
Nonstop2h 11m
Charlotte Douglas
Sun 5/24
7:44 pm-11:26 pm
1 stop4h 42m
$262
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from O'Hare Intl to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from O'Hare Intl with our price prediction graph.
ORD-CLT
ORD-AGS
ORD-GSP
ORD-MYR
ORD-FLO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Chicago O'Hare Intl Airport to South Carolina
ORD-USSC
ORD-CLT
ORD-AGS
ORD-GSP
ORD-MYR
How far ahead should I book a flight from Chicago O'Hare Intl Airport to South Carolina?
The price you pay for your flight from Chicago O'Hare Intl Airport to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 83 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Chicago O'Hare Intl Airport to South Carolina?
Currently, May is the cheapest month in which you can book a flight from Chicago O'Hare Intl Airport to South Carolina (average of $33). Flying from Chicago O'Hare Intl Airport to South Carolina in March is currently the most expensive (average of $180). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from ORD to SC?
Find hourly flight availability from O'Hare Intl to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 24, 2026.
Unlike in the morning, when flights are generally more expensive, you can save up to 21% on flights from Chicago O'Hare Intl Airport to South Carolina by exploring options for tickets in the evening.
What is the cheapest day to fly from Chicago O'Hare Intl Airport to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from O'Hare Intl to South Carolina. Price data was last updated on April 18, 2026.
Travelers seeking maximum savings on their Chicago O'Hare Intl Airport to South Carolina flight should consider departing on Sunday afternoons when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.
Weekly flight availability from Chicago O'Hare Intl Airport to South Carolina
Explore weekly flight availability from O'Hare Intl to South Carolina. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated April 24, 2026.
The most flights from ORD to USSC are scheduled on a Friday (23 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (16 on average).
How much does it cost to fly round-trip from Chicago O'Hare Intl Airport to South Carolina?
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 24, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Chicago O'Hare Intl Airport to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Boarding
8.1
Crew
8.5
Overall
7.9
Comfort
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Entertainment
7.8
Boarding
8.1
Crew
8.5
Overall
7.9
Comfort
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Entertainment
7.8
Boarding
8.1
Crew
8.5
Overall
7.9
Comfort
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Entertainment
7.8
Boarding
8.1
Crew
8.5
Overall
7.9
Comfort
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Entertainment
7.8
Boarding
8.1
Crew
8.5
Overall
7.9
Comfort
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from O'Hare Intl to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for O'Hare Intl to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from O'Hare Intl to South Carolina by cabin class
Find flights from O'Hare Intl to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
O'Hare Intl and South Carolina flights
Browse other O'Hare Intl and South Carolina flight options. Last updated on April 24, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
O'Hare Intl to South Carolina flights
Consider these flights traveling from O'Hare Intl to South Carolina.
Top 4 airlines flying from O'Hare Intl to South Carolina
Discover the top 4 airlines that operate flights from O'Hare Intl to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$52 | Average$175 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$146 | Average$264 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$186 | Average$375 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$202 | Average$363 | FlexibilityNo cancel fee | On-time71% |