To save up to 21% on this flight, we recommend booking at least 16 days prior to travel. The price may fluctuate and will likely increase closer to your departure date. Users on Cheapflights have found tickets from La Crosse to South Carolina from $234 1-2 weeks out and tickets from $306 for flights departing within the next 72 hours.
Due to multiple factors, expect to potentially pay more when booking in December. For low rates, August can be a great choice for travel to South Carolina. Flights to South Carolina from La Crosse in August are about $324 on average during August, but can be found for as low as $124.