$383+ Cheap flights from La Crosse (LSE) to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/2. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — CHS
Nov 25 — Dec 21
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from La Crosse to South Carolina
Cheapest
Best
Last-minute
One-way
Cheapest flights from La Crosse to South CarolinaExplore the most affordable flight options available from La Crosse to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 26, 2026.
Explore the most affordable flight options available from La Crosse to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 26, 2026.
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2412:26 pm -
1 stop8h 34m
Sat 11/286:39 am -
1 stop6h 17m
Deal found 10/22![American Airlines logo]()
$747
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:57 am -
1 stop4h 27m
Sun 11/85:05 am -
2 stops7h 48m
Deal found 10/21![American Airlines logo]()
$776
Best flights from La Crosse to South CarolinaDiscover carefully curated flight deals from La Crosse to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 26, 2026.
Discover carefully curated flight deals from La Crosse to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 26, 2026.
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/105:34 am -
1 stop17h 10m
Tue 3/26:26 am -
1 stop18h 56m
Deal found 10/23![American Airlines logo]()
$526
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/128:04 pm -
1 stop18h 39m
Tue 3/26:26 am -
1 stop13h 28m
Deal found 10/23![American Airlines logo]()
$526
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1112:05 pm -
1 stop11h 12m
Tue 3/24:36 pm -
1 stop8h 46m
Deal found 10/23![American Airlines logo]()
$528
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/2612:29 pm -
1 stop10h 15m
Fri 1/294:17 pm -
1 stop20h 42m
Deal found 10/22![American Airlines logo]()
$528
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/145:27 am -
2 stops8h 29m
Wed 3/311:06 am -
2 stops8h 48m
Deal found 10/23![American Airlines logo]()
$553
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/1912:29 pm -
2 stops8h 59m
Sat 1/231:50 pm -
2 stops7h 07m
Deal found 10/25![American Airlines logo]()
$553
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/1912:29 pm -
2 stops8h 59m
Tue 1/263:32 pm -
2 stops9h 22m
Deal found 10/25![American Airlines logo]()
$553
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/1912:29 pm -
2 stops8h 59m
Thu 1/283:32 pm -
2 stops9h 22m
Deal found 10/25![American Airlines logo]()
$553
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/1811:27 am -
2 stops10h 01m
Fri 1/2211:41 am -
2 stops9h 16m
Deal found 10/25![American Airlines logo]()
$553
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2412:26 pm -
1 stop8h 34m
Sat 11/286:39 am -
1 stop6h 17m
Deal found 10/22![American Airlines logo]()
$747
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/245:34 am -
2 stops8h 28m
Wed 1/271:50 pm -
2 stops7h 07m
Deal found 10/25![American Airlines logo]()
$952
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/215:34 am -
3 stops9h 46m
Mon 1/251:50 pm -
2 stops7h 07m
Deal found 10/25![American Airlines logo]()
$1,057
Last-minute flights from La Crosse to South CarolinaDiscover last-minute flight deals from La Crosse to South Carolina. Data last updated October 26, 2026 and is based on user searches.
Discover last-minute flight deals from La Crosse to South Carolina. Data last updated October 26, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:57 am -
1 stop4h 27m
Sun 11/85:05 am -
2 stops7h 48m
Deal found 10/21![American Airlines logo]()
$776
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2412:26 pm -
1 stop8h 34m
Sat 11/286:39 am -
1 stop6h 17m
Deal found 10/22![American Airlines logo]()
$747
One-way flights from La Crosse to South CarolinaSearch for one-way flight options from La Crosse to South Carolina. Find affordable one-way fares based on user searches. Data last updated October 26, 2026.
Search for one-way flight options from La Crosse to South Carolina. Find affordable one-way fares based on user searches. Data last updated October 26, 2026.
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/165:55 am -
1 stop15h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![American Airlines logo]()
$383
Find flight deals from La Crosse to South Carolina
Keep the following information in mind while searching for La Crosse to South Carolina flight deals. Data was last updated October 26, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $458 (American Airlines) |
One-way from | $383 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from La Crosse to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 26, 2026.
Use the filters below to find and compare flights from La Crosse to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
La CrosseCharleston
LSE La Crosse - CHS Charleston
LSECHS
La Crosse
Tue 3/2
8:04 pm-3:43 pm
1 stop18h 39m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$383
La CrosseCharleston
LSE La Crosse - CHS Charleston
LSECHS
La Crosse
Wed 12/16
5:55 am-10:08 pm
1 stop15h 13m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$383
La CrosseCharleston
LSE La Crosse - CHS Charleston
LSECHS
La Crosse
Wed 2/10
5:34 am-11:44 pm
1 stop17h 10m
Charleston
Tue 3/2
6:26 am-12:22 am
1 stop18h 56m
$526
La CrosseCharleston
LSE La Crosse - CHS Charleston
LSECHS
La Crosse
Fri 2/12
8:04 pm-3:43 pm
1 stop18h 39m
Charleston
Tue 3/2
6:26 am-6:54 pm
1 stop13h 28m
$526
La CrosseCharleston
LSE La Crosse - CHS Charleston
LSECHS
La Crosse
Thu 2/11
12:05 pm-12:17 am
1 stop11h 12m
Charleston
Tue 3/2
4:36 pm-12:22 am
1 stop8h 46m
$528
La CrosseCharleston
LSE La Crosse - CHS Charleston
LSECHS
La Crosse
Tue 1/26
12:29 pm-11:44 pm
1 stop10h 15m
Charleston
Fri 1/29
4:17 pm-11:59 am
1 stop20h 42m
$528
La CrosseCharleston
LSE La Crosse - CHS Charleston
LSECHS
La Crosse
Sun 2/14
5:27 am-2:56 pm
2 stops8h 29m
Charleston
Wed 3/3
11:06 am-6:54 pm
2 stops8h 48m
$553
La CrosseMyrtle Beach
LSE La Crosse - MYR Myrtle Beach Intl
LSEMYR
La Crosse
Tue 1/19
12:29 pm-10:28 pm
2 stops8h 59m
Myrtle Beach Intl
Sat 1/23
1:50 pm-7:57 pm
2 stops7h 07m
$553
La CrosseMyrtle Beach
LSE La Crosse - MYR Myrtle Beach Intl
LSEMYR
La Crosse
Tue 1/19
12:29 pm-10:28 pm
2 stops8h 59m
Myrtle Beach Intl
Tue 1/26
3:32 pm-11:54 pm
2 stops9h 22m
$553
La CrosseMyrtle Beach
LSE La Crosse - MYR Myrtle Beach Intl
LSEMYR
La Crosse
Tue 1/19
12:29 pm-10:28 pm
2 stops8h 59m
Myrtle Beach Intl
Thu 1/28
3:32 pm-11:54 pm
2 stops9h 22m
$553
Showing 1-10 of 14 resultsSorted by cheapest first
Best time to book a flight from La Crosse to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from La Crosse with our price prediction graph.
LSE-CHS
LSE-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from La Crosse to South Carolina
LSE-USSC
LSE-CHS
LSE-MYR
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated October 26, 2026.
Read reviews from past customers who have flown American Airlines from La Crosse to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Food
6.4
Overall
7.0
Comfort
7.1
Crew
7.9
Boarding
7.4
Entertainment
6.8
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Food
6.4
Overall
7.0
Comfort
7.1
Crew
7.9
Boarding
7.4
Entertainment
6.8
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from La Crosse to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for La Crosse to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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La Crosse and South Carolina flights
Browse other La Crosse and South Carolina flight options. Last updated on October 26, 2026.
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La Crosse to South Carolina flights
Consider these flights traveling from La Crosse to South Carolina.
Top airline flying from La Crosse to South Carolina
Discover the top airline that operate flights from La Crosse to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$299 | Average$580 | FlexibilityNo cancel fee | On-time71% |