$299+ Cheap flights from La Crosse (LSE) to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/31. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — CHS
May 25 — Jun 11
Round-trip
1 adult, Economy
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Cheapest flights from La Crosse to South CarolinaExplore the most affordable flight options available from La Crosse to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 25, 2026.
Explore the most affordable flight options available from La Crosse to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 25, 2026.
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:19 pm
LSE
- CHS
1 stop4h 56m
American Airlines
Wed 11/46:40 pm
CHS
- LSE
1 stop6h 09m
American Airlines
Deal found 4/24![American Airlines logo]()
$299
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2611:21 am
LSE
- GSP
2 stops9h 27m
American Airlines
Sat 10/178:14 pm
GSP
- LSE
1 stop4h 05m
American Airlines
Deal found 4/21![American Airlines logo]()
$329
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:40 am
LSE
- CHS
1 stop5h 09m
American Airlines
Tue 5/1212:29 pm
CHS
- LSE
1 stop6h 37m
American Airlines
Deal found 4/24![American Airlines logo]()
$342
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2910:05 am
LSE
- CLT
1 stop7h 36m
American Airlines
Sat 5/96:00 pm
CLT
- LSE
1 stop6h 54m
American Airlines
Deal found 4/21![American Airlines logo]()
$342
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:40 am
LSE
- SAV
1 stop6h 43m
American Airlines
Tue 5/121:53 pm
SAV
- LSE
1 stop5h 13m
American Airlines
Deal found 4/24![American Airlines logo]()
$342
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:21 am
LSE
- GSP
2 stops9h 42m
American Airlines
Sat 10/108:14 pm
GSP
- LSE
1 stop4h 05m
American Airlines
Deal found 4/21![American Airlines logo]()
$348
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:36 pm
LSE
- SAV
1 stop4h 41m
American Airlines
Mon 5/115:40 am
SAV
- LSE
1 stop4h 44m
American Airlines
Deal found 4/22![American Airlines logo]()
$358
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/55:32 pm
LSE
- CLT
1 stop5h 26m
American Airlines
Sat 6/138:10 pm
CLT
- LSE
1 stop4h 47m
American Airlines
Deal found 4/25![American Airlines logo]()
$371
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/36:37 pm
LSE
- SAV
1 stop4h 40m
American Airlines
Sat 5/95:40 am
SAV
- LSE
1 stop4h 44m
American Airlines
Deal found 4/25![American Airlines logo]()
$425
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:36 pm
LSE
- SAV
1 stop4h 41m
American Airlines
Sun 5/105:40 am
SAV
- LSE
1 stop4h 44m
American Airlines
Deal found 4/25![American Airlines logo]()
$433
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/111:45 am
LSE
- GSP
1 stop5h 28m
American Airlines
Sat 8/87:39 pm
GSP
- LSE
1 stop4h 39m
American Airlines
Deal found 4/25![American Airlines logo]()
$454
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:36 pm
LSE
- CLT
1 stop4h 15m
American Airlines
Mon 5/258:10 pm
CLT
- LSE
1 stop4h 56m
American Airlines
Deal found 4/21![American Airlines logo]()
$455
Best flights from La Crosse to South CarolinaDiscover carefully curated flight deals from La Crosse to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 25, 2026.
Discover carefully curated flight deals from La Crosse to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 25, 2026.
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:40 am
LSE
- CHS
1 stop5h 09m
American Airlines
Tue 5/1212:29 pm
CHS
- LSE
1 stop6h 37m
American Airlines
Deal found 4/24![American Airlines logo]()
$342
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/309:43 am
LSE
- GSP
1 stop10h 34m
United Airlines
Sat 7/47:40 pm
GSP
- LSE
2 stops14h 28m
United Airlines
Deal found 4/22![United Airlines logo]()
$628
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:19 pm
LSE
- CLT
1 stop4h 29m
American Airlines
Sat 10/106:00 pm
CLT
- LSE
1 stop6h 19m
American Airlines
Deal found 4/21![American Airlines logo]()
$342
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:40 am
LSE
- SAV
1 stop6h 43m
American Airlines
Tue 5/121:53 pm
SAV
- LSE
1 stop5h 13m
American Airlines
Deal found 4/24![American Airlines logo]()
$342
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:36 pm
LSE
- SAV
1 stop4h 41m
American Airlines
Mon 5/115:40 am
SAV
- LSE
1 stop4h 44m
American Airlines
Deal found 4/22![American Airlines logo]()
$358
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/55:32 pm
LSE
- CLT
1 stop5h 26m
American Airlines
Sat 6/138:10 pm
CLT
- LSE
1 stop4h 47m
American Airlines
Deal found 4/25![American Airlines logo]()
$371
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:36 pm
LSE
- SAV
1 stop4h 41m
American Airlines
Sun 5/105:40 am
SAV
- LSE
1 stop4h 44m
American Airlines
Deal found 4/25![American Airlines logo]()
$433
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/57:11 pm
LSE
- CLT
2 stops27h 48m
United Airlines
Sat 6/139:55 am
CLT
- LSE
1 stop9h 15m
United Airlines
Deal found 4/25![United Airlines logo]()
$644
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:36 pm
LSE
- SAV
1 stop4h 41m
American Airlines
Sun 5/105:40 am
SAV
- LSE
1 stop4h 44m
American Airlines
Deal found 4/25![American Airlines logo]()
$433
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:15 am
LSE
- SAV
3 stops15h 44m
United Airlines
Tue 9/297:00 pm
SAV
- LSE
2 stops19h 05m
United Airlines
Deal found 4/20![United Airlines logo]()
$658
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/185:40 am
LSE
- CLT
1 stop5h 10m
American Airlines
Mon 5/256:25 pm
CLT
- LSE
1 stop6h 41m
American Airlines
Deal found 4/24![American Airlines logo]()
$455
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/69:42 am
LSE
- CLT
2 stops10h 34m
United Airlines
Sat 10/106:00 am
CLT
- LSE
2 stops8h 05m
United Airlines
Deal found 4/21![United Airlines logo]()
$829
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:36 pm
LSE
- CHS
1 stop16h 13m
American Airlines
Tue 5/127:07 am
CHS
- LSE
1 stop17h 47m
American Airlines
Deal found 4/23![American Airlines logo]()
$527
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/246:15 am
LSE
- GSP
2 stops7h 05m
United Airlines
Wed 6/247:40 pm
GSP
- LSE
2 stops14h 28m
United Airlines
Deal found 4/23![United Airlines logo]()
$975
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:40 am
LSE
- CHS
1 stop16h 26m
American Airlines
Sun 5/107:07 am
CHS
- LSE
1 stop17h 47m
American Airlines
Deal found 4/25![American Airlines logo]()
$687
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/105:40 am
LSE
- CHS
2 stops7h 30m
American Airlines
Thu 5/1412:29 pm
CHS
- LSE
1 stop6h 37m
American Airlines
Deal found 4/25![American Airlines logo]()
$746
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/246:00 am
LSE
- GSP
1 stop4h 03m
American Airlines
Wed 6/246:00 pm
GSP
- LSE
2 stops6h 57m
American Airlines
Deal found 4/23![American Airlines logo]()
$1,006
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/305:40 am
LSE
- CHS
1 stop16h 28m
American Airlines
Sat 5/27:07 am
CHS
- LSE
1 stop17h 47m
American Airlines
Deal found 4/23![American Airlines logo]()
$1,084
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/85:40 am
LSE
- CHS
2 stops10h 12m
American Airlines
Sun 5/106:35 am
CHS
- LSE
2 stops12h 31m
American Airlines
Deal found 4/25![American Airlines logo]()
$1,124
Last-minute flights from La Crosse to South CarolinaDiscover last-minute flight deals from La Crosse to South Carolina. Data last updated April 25, 2026 and is based on user searches.
Discover last-minute flight deals from La Crosse to South Carolina. Data last updated April 25, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2910:05 am
LSE
- CLT
1 stop7h 36m
American Airlines
Sat 5/96:00 pm
CLT
- LSE
1 stop6h 54m
American Airlines
Deal found 4/21![American Airlines logo]()
$342
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/36:37 pm
LSE
- SAV
1 stop4h 40m
American Airlines
Sat 5/95:40 am
SAV
- LSE
1 stop4h 44m
American Airlines
Deal found 4/25![American Airlines logo]()
$425
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:40 am
LSE
- CHS
1 stop5h 09m
American Airlines
Tue 5/1212:29 pm
CHS
- LSE
1 stop6h 37m
American Airlines
Deal found 4/24![American Airlines logo]()
$342
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:40 am
LSE
- SAV
1 stop6h 43m
American Airlines
Tue 5/121:53 pm
SAV
- LSE
1 stop5h 13m
American Airlines
Deal found 4/24![American Airlines logo]()
$342
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:36 pm
LSE
- SAV
1 stop4h 41m
American Airlines
Mon 5/115:40 am
SAV
- LSE
1 stop4h 44m
American Airlines
Deal found 4/22![American Airlines logo]()
$358
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:36 pm
LSE
- SAV
1 stop4h 41m
American Airlines
Sun 5/105:40 am
SAV
- LSE
1 stop4h 44m
American Airlines
Deal found 4/25![American Airlines logo]()
$433
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:40 am
LSE
- CHS
1 stop16h 26m
American Airlines
Sun 5/107:07 am
CHS
- LSE
1 stop17h 47m
American Airlines
Deal found 4/25![American Airlines logo]()
$687
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:36 pm
LSE
- CHS
1 stop16h 13m
American Airlines
Tue 5/127:07 am
CHS
- LSE
1 stop17h 47m
American Airlines
Deal found 4/23![American Airlines logo]()
$527
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:36 pm
LSE
- CHS
1 stop16h 13m
American Airlines
Sun 5/107:07 am
CHS
- LSE
1 stop17h 47m
American Airlines
Deal found 4/25![American Airlines logo]()
$668
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/105:40 am
LSE
- CHS
1 stop5h 09m
American Airlines
Thu 5/1412:29 pm
CHS
- LSE
1 stop6h 37m
American Airlines
Deal found 4/25![American Airlines logo]()
$740
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:36 pm
LSE
- CLT
1 stop4h 15m
American Airlines
Mon 5/258:10 pm
CLT
- LSE
1 stop4h 56m
American Airlines
Deal found 4/21![American Airlines logo]()
$455
One-way flights from La Crosse to South CarolinaSearch for one-way flight options from La Crosse to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 25, 2026.
Search for one-way flight options from La Crosse to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 25, 2026.
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/105:40 am
LSE
- SAV
1 stop6h 43m
American Airlines
Deal found 4/24![American Airlines logo]()
$373
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/165:40 am
LSE
- GSP
2 stops12h 03m
American Airlines
Deal found 4/25![American Airlines logo]()
$467
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/610:05 am
LSE
- CLT
1 stop6h 00m
American Airlines
Deal found 4/22![American Airlines logo]()
$489
This KAYAK deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/105:40 am
LSE
- CLT
1 stop12h 01m
American Airlines
Deal found 4/24![American Airlines logo]()
$500
This deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/107:20 pm
LSE
- CLT
1 stop4h 35m
United Airlines
Deal found 4/21![United Airlines logo]()
$546
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:37 pm
LSE
- GSP
1 stop4h 22m
American Airlines
Deal found 4/22![American Airlines logo]()
$558
Find flight deals from La Crosse to South Carolina
Keep the following information in mind while searching for La Crosse to South Carolina flight deals. Data was last updated April 25, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $329 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from La Crosse to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 25, 2026.
Use the filters below to find and compare flights from La Crosse to South Carolina that are best for you.
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Cheapest round-trip
La CrosseCharleston
LSE - CHS
LSECHS
La Crosse
Tue 5/5
5:40 am-11:49 am
1 stop5h 09m
Charleston
Tue 5/12
12:29 pm-6:06 pm
1 stop6h 37m
$342
La CrosseCharlotte
LSE - CLT
LSECLT
La Crosse
Tue 10/6
6:19 pm-11:48 pm
1 stop4h 29m
Charlotte Douglas
Sat 10/10
6:00 pm-11:19 pm
1 stop6h 19m
$342
La CrosseSavannah
LSE - SAV
LSESAV
La Crosse
Tue 5/5
5:40 am-1:23 pm
1 stop6h 43m
Savannah/Hilton Head
Tue 5/12
1:53 pm-6:06 pm
1 stop5h 13m
$342
Quickest round-trip
La CrosseSavannah
LSE - SAV
LSESAV
La Crosse
Thu 5/7
6:36 pm-12:17 am
1 stop4h 41m
Savannah/Hilton Head
Mon 5/11
5:40 am-9:24 am
1 stop4h 44m
$358
La CrosseCharlotte
LSE - CLT
LSECLT
La Crosse
Fri 6/5
5:32 pm-11:58 pm
1 stop5h 26m
Charlotte Douglas
Sat 6/13
8:10 pm-11:57 pm
1 stop4h 47m
$371
La CrosseSavannah
LSE - SAV
LSESAV
La Crosse
Fri 5/8
6:36 pm-12:17 am
1 stop4h 41m
Savannah/Hilton Head
Sun 5/10
5:40 am-9:24 am
1 stop4h 44m
$433
La CrosseSavannah
LSE - SAV
LSESAV
La Crosse
Thu 5/7
6:36 pm-12:17 am
1 stop4h 41m
Savannah/Hilton Head
Sun 5/10
5:40 am-9:24 am
1 stop4h 44m
$433
La CrosseCharlotte
LSE - CLT
LSECLT
La Crosse
Mon 5/18
5:40 am-11:50 am
1 stop5h 10m
Charlotte Douglas
Mon 5/25
6:25 pm-12:06 am
1 stop6h 41m
$455
La CrosseCharleston
LSE - CHS
LSECHS
La Crosse
Fri 5/8
6:36 pm-11:49 am
1 stop16h 13m
Charleston
Tue 5/12
7:07 am-11:54 pm
1 stop17h 47m
$527
La CrosseGreenville
LSE - GSP
LSEGSP
La Crosse
Tue 6/30
9:43 am-9:17 pm
1 stop10h 34m
Greenville
Sat 7/4
7:40 pm-9:08 am
2 stops14h 28m
$628
Showing 1-10 of 25 resultsSorted by cheapest first
Best time to book a flight from La Crosse to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from La Crosse with our price prediction graph.
LSE-SAV
LSE-GSP
LSE-CLT
LSE-CHS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from La Crosse to South Carolina
LSE-USSC
LSE-SAV
LSE-GSP
LSE-CLT
LSE-CHS
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 25, 2026.
Read reviews from past customers who have flown American Airlines from La Crosse to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.5
Crew
7.9
Comfort
7.2
Overall
7.1
Entertainment
6.9
Food
6.4
Reviews
1 / 20
4.0
OkayElizabeth,Mar 2026
ORD - MIA
Boarding
7.5
Crew
7.9
Comfort
7.2
Overall
7.1
Entertainment
6.9
Food
6.4
Reviews
1 / 20
4.0
OkayElizabeth,Mar 2026
ORD - MIA
Related info for your journey
Find useful and relevant information for your journey from La Crosse to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for La Crosse to South Carolina
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Complete your trip
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La Crosse and South Carolina flights
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Consider these flights traveling from La Crosse to South Carolina.
Top airline flying from La Crosse to South Carolina
Discover the top airline that operate flights from La Crosse to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 25, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$308 | Average$608 | FlexibilityNo cancel fee | On-time71% |