$280+ Cheap flights from La Crosse (LSE) to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/7. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — CHS
Oct 10 — Oct 171
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from La Crosse to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from La Crosse to South Carolina
Cheapest
Best
Last-minute
Cheapest flights from La Crosse to South CarolinaExplore the most affordable flight options available from La Crosse to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
Explore the most affordable flight options available from La Crosse to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:52 pm -
1 stop4h 22m
Sat 11/147:35 am -
1 stop5h 18m
Deal found 9/9![American Airlines logo]()
$280
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2212:26 pm -
1 stop4h 27m
Sat 9/267:24 am -
1 stop4h 58m
Deal found 9/7![American Airlines logo]()
$352
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/195:53 am -
1 stop4h 23m
Sat 10/31:04 pm -
1 stop4h 48m
Deal found 9/5![American Airlines logo]()
$352
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/112:24 pm -
2 stops7h 36m
Sat 11/76:03 am -
2 stops13h 13m
Deal found 9/6![American Airlines logo]()
$366
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/35:57 am -
2 stops7h 29m
Tue 11/103:00 pm -
2 stops10h 18m
Deal found 9/6![American Airlines logo]()
$371
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/56:00 am -
2 stops8h 47m
Wed 12/97:13 am -
1 stop5h 40m
Deal found 9/5![American Airlines logo]()
$376
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/56:00 am -
2 stops8h 47m
Sat 12/128:12 am -
2 stops11h 04m
Deal found 9/5![American Airlines logo]()
$381
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/86:00 am -
1 stop4h 24m
Sat 12/126:13 am -
1 stop6h 40m
Deal found 9/5![American Airlines logo]()
$406
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:04 am -
2 stops9h 28m
Tue 11/102:16 pm -
2 stops11h 02m
Deal found 9/6![American Airlines logo]()
$407
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:04 am -
1 stop7h 10m
Tue 11/106:05 pm -
1 stop7h 13m
Deal found 9/7![American Airlines logo]()
$410
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:00 am -
1 stop4h 24m
Sat 12/1212:17 pm -
1 stop6h 59m
Deal found 9/5![American Airlines logo]()
$423
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:57 am -
1 stop4h 27m
Mon 11/97:13 am -
1 stop5h 40m
Deal found 9/8![American Airlines logo]()
$430
Best flights from La Crosse to South CarolinaDiscover carefully curated flight deals from La Crosse to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
Discover carefully curated flight deals from La Crosse to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:52 pm -
1 stop4h 22m
Sat 11/147:35 am -
1 stop5h 18m
Deal found 9/9![American Airlines logo]()
$280
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/112:24 pm -
2 stops7h 36m
Sat 11/76:03 am -
2 stops13h 13m
Deal found 9/6![American Airlines logo]()
$366
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/512:24 pm -
2 stops9h 35m
Tue 12/87:13 am -
1 stop5h 40m
Deal found 9/5![American Airlines logo]()
$376
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:04 am -
1 stop7h 10m
Tue 11/104:52 pm -
2 stops8h 26m
Deal found 9/7![American Airlines logo]()
$416
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:00 am -
1 stop5h 05m
Sun 11/226:33 pm -
1 stop6h 47m
Deal found 9/7![American Airlines logo]()
$430
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:57 am -
1 stop4h 18m
Sun 11/87:35 am -
1 stop5h 18m
Deal found 9/6![American Airlines logo]()
$430
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/612:24 pm -
2 stops9h 13m
Mon 11/97:13 am -
1 stop5h 40m
Deal found 9/8![American Airlines logo]()
$436
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/66:00 am -
2 stops7h 46m
Sat 12/124:24 pm -
2 stops8h 54m
Deal found 9/5![American Airlines logo]()
$456
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/912:24 pm -
2 stops9h 27m
Mon 12/142:06 pm -
2 stops11h 12m
Deal found 9/5![American Airlines logo]()
$456
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/106:00 am -
2 stops7h 46m
Sun 12/1312:17 pm -
1 stop6h 59m
Deal found 9/5![American Airlines logo]()
$526
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:55 pm -
1 stop15h 13m
Sun 11/111:39 am -
1 stop13h 39m
Deal found 9/7![American Airlines logo]()
$546
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/712:23 pm -
2 stops10h 36m
Mon 10/127:15 am -
2 stops12h 05m
Deal found 9/7![American Airlines logo]()
$588
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/85:57 am -
2 stops7h 30m
Sun 11/156:01 am -
2 stops13h 15m
Deal found 9/9![American Airlines logo]()
$595
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:53 am -
1 stop4h 33m
Fri 10/93:22 pm -
2 stops9h 37m
Deal found 9/8![American Airlines logo]()
$605
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2912:23 pm -
2 stops8h 27m
Sun 11/82:57 pm -
2 stops10h 21m
Deal found 9/6![American Airlines logo]()
$615
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/76:00 am -
1 stop4h 24m
Mon 12/147:13 am -
1 stop5h 40m
Deal found 9/5![American Airlines logo]()
$626
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/86:53 pm -
1 stop15h 31m
Fri 12/114:14 pm -
1 stop20h 39m
Deal found 9/5![American Airlines logo]()
$634
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:55 pm -
1 stop15h 36m
Tue 11/103:52 pm -
2 stops9h 26m
Deal found 9/6![American Airlines logo]()
$703
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:57 am -
2 stops7h 22m
Fri 11/62:49 pm -
2 stops22h 04m
Deal found 9/6![American Airlines logo]()
$724
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/312:24 pm -
2 stops8h 00m
Wed 11/410:31 am -
2 stops8h 45m
Deal found 9/6![American Airlines logo]()
$999
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/212:24 pm -
2 stops8h 00m
Thu 11/511:04 am -
2 stops8h 12m
Deal found 9/6![American Airlines logo]()
$1,221
Last-minute flights from La Crosse to South CarolinaDiscover last-minute flight deals from La Crosse to South Carolina. Data last updated September 10, 2026 and is based on user searches.
Discover last-minute flight deals from La Crosse to South Carolina. Data last updated September 10, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/175:22 pm -
1 stop5h 42m
Sun 9/207:34 am -
1 stop4h 48m
Deal found 9/6![American Airlines logo]()
$540
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/195:53 am -
1 stop4h 23m
Sat 10/31:04 pm -
1 stop4h 48m
Deal found 9/5![American Airlines logo]()
$352
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/195:53 am -
1 stop5h 17m
Sun 10/47:34 am -
1 stop4h 48m
Deal found 9/5![American Airlines logo]()
$446
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2212:26 pm -
1 stop4h 27m
Sat 9/267:24 am -
1 stop4h 58m
Deal found 9/7![American Airlines logo]()
$352
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:55 pm -
1 stop13h 44m
Mon 10/1910:50 pm -
1 stop14h 03m
Deal found 9/7![American Airlines logo]()
$504
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:04 am -
1 stop7h 10m
Tue 11/106:05 pm -
1 stop7h 13m
Deal found 9/7![American Airlines logo]()
$410
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2912:23 pm -
2 stops8h 27m
Wed 11/46:03 am -
2 stops13h 13m
Deal found 9/6![American Airlines logo]()
$493
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:55 pm -
1 stop15h 13m
Sun 11/111:39 am -
1 stop13h 39m
Deal found 9/7![American Airlines logo]()
$546
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:04 am -
2 stops9h 28m
Tue 11/102:16 pm -
2 stops11h 02m
Deal found 9/6![American Airlines logo]()
$407
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:04 am -
2 stops9h 28m
Sat 11/710:29 am -
2 stops8h 47m
Deal found 9/6![American Airlines logo]()
$443
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:04 am -
2 stops9h 28m
Thu 11/52:49 pm -
2 stops10h 29m
Deal found 9/6![American Airlines logo]()
$482
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:04 am -
2 stops9h 28m
Fri 11/612:57 pm -
2 stops6h 19m
Deal found 9/6![American Airlines logo]()
$529
Find flight deals from La Crosse to South Carolina
Keep the following information in mind while searching for La Crosse to South Carolina flight deals. Data was last updated September 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $280 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from La Crosse to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
Use the filters below to find and compare flights from La Crosse to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
La CrosseCharlotte
LSE La Crosse - CLT Charlotte Douglas
LSECLT
La Crosse
Sat 11/7
6:52 pm-12:14 am
1 stop4h 22m
Charlotte Douglas
Sat 11/14
7:35 am-11:53 am
1 stop5h 18m
$280
La CrosseSavannah
LSE La Crosse - SAV Savannah/Hilton Head
LSESAV
La Crosse
Sun 11/1
12:24 pm-9:00 pm
2 stops7h 36m
Savannah/Hilton Head
Sat 11/7
6:03 am-6:16 pm
2 stops13h 13m
$366
La CrosseCharleston
LSE La Crosse - CHS Charleston
LSECHS
La Crosse
Sat 12/5
12:24 pm-10:59 pm
2 stops9h 35m
Charleston
Tue 12/8
7:13 am-11:53 am
1 stop5h 40m
$376
La CrosseCharlotte
LSE La Crosse - CLT Charlotte Douglas
LSECLT
La Crosse
Thu 10/29
7:04 am-3:14 pm
1 stop7h 10m
Charlotte Douglas
Tue 11/10
4:52 pm-12:18 am
2 stops8h 26m
$416
La CrosseCharlotte
LSE La Crosse - CLT Charlotte Douglas
LSECLT
La Crosse
Thu 11/19
6:00 am-12:05 pm
1 stop5h 05m
Charlotte Douglas
Sun 11/22
6:33 pm-12:20 am
1 stop6h 47m
$430
Quickest round-trip
La CrosseCharlotte
LSE La Crosse - CLT Charlotte Douglas
LSECLT
La Crosse
Fri 11/6
5:57 am-11:15 am
1 stop4h 18m
Charlotte Douglas
Sun 11/8
7:35 am-11:53 am
1 stop5h 18m
$430
La CrosseCharleston
LSE La Crosse - CHS Charleston
LSECHS
La Crosse
Fri 11/6
12:24 pm-10:37 pm
2 stops9h 13m
Charleston
Mon 11/9
7:13 am-11:53 am
1 stop5h 40m
$436
La CrosseCharleston
LSE La Crosse - CHS Charleston
LSECHS
La Crosse
Sun 12/6
6:00 am-2:46 pm
2 stops7h 46m
Charleston
Sat 12/12
4:24 pm-12:18 am
2 stops8h 54m
$456
La CrosseCharleston
LSE La Crosse - CHS Charleston
LSECHS
La Crosse
Wed 12/9
12:24 pm-10:51 pm
2 stops9h 27m
Charleston
Mon 12/14
2:06 pm-12:18 am
2 stops11h 12m
$456
La CrosseCharleston
LSE La Crosse - CHS Charleston
LSECHS
La Crosse
Thu 12/10
6:00 am-2:46 pm
2 stops7h 46m
Charleston
Sun 12/13
12:17 pm-6:16 pm
1 stop6h 59m
$526
Showing 1-10 of 21 resultsSorted by cheapest first
Best time to book a flight from La Crosse to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from La Crosse with our price prediction graph.
LSE-GSP
LSE-CLT
LSE-SAV
LSE-CHS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from La Crosse to South Carolina
LSE-USSC
LSE-GSP
LSE-CLT
LSE-SAV
LSE-CHS
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 10, 2026.
Read reviews from past customers who have flown American Airlines from La Crosse to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.2
Entertainment
6.8
Overall
7.1
Boarding
7.5
Crew
7.9
Food
6.4
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Comfort
7.2
Entertainment
6.8
Overall
7.1
Boarding
7.5
Crew
7.9
Food
6.4
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from La Crosse to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Top destinations
Alternative routes for La Crosse to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from La Crosse to South Carolina by cabin class
Find flights from La Crosse to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
La Crosse and South Carolina flights
Browse other La Crosse and South Carolina flight options. Last updated on September 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
La Crosse to South Carolina flights
Consider these flights traveling from La Crosse to South Carolina.
Top airline flying from La Crosse to South Carolina
Discover the top airline that operate flights from La Crosse to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$299 | Average$580 | FlexibilityNo cancel fee | On-time71% |