$135+ Cheap flights from South Carolina to Des Moines (DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/6. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
Nov 9 — Nov 161
Round-trip
1 adult, Economy
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Cheapest flights from South Carolina to Des MoinesExplore the most affordable flight options available from South Carolina to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 10, 2026.
Explore the most affordable flight options available from South Carolina to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 10, 2026.
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:40 am -
1 stop6h 04m
Mon 11/162:59 pm -
1 stop4h 02m
Deal found 10/6![Delta logo]()
$269
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:30 am -
1 stop7h 09m
Sat 12/121:15 pm -
2 stops9h 25m
Deal found 10/8![United Airlines logo]()
$274
This American Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:42 pm -
1 stop6h 44m
Mon 11/163:31 pm -
1 stop5h 27m
Deal found 10/6![American Airlines logo]()
$306
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/311:33 am -
1 stop4h 43m
Tue 11/1011:36 am -
1 stop4h 34m
Deal found 10/6![Delta logo]()
$327
This Kiwi.com deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:00 am -
2 stops36h 02m
Sun 10/256:37 pm -
1 stop25h 24m
Deal found 10/6![Multiple Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/45:17 pm -
1 stop6h 48m
Thu 11/57:23 am -
1 stop7h 44m
Deal found 10/7![American Airlines logo]()
$341
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/68:32 pm -
1 stop4h 25m
Fri 11/137:23 am -
1 stop7h 01m
Deal found 10/8![American Airlines logo]()
$343
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:42 pm -
1 stop6h 44m
Sun 11/83:31 pm -
1 stop5h 27m
Deal found 10/8![American Airlines logo]()
$343
This American Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/268:12 pm -
1 stop4h 46m
Wed 10/287:08 am -
1 stop5h 23m
Deal found 10/6![American Airlines logo]()
$346
This Kiwi.com deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/63:14 pm -
1 stop8h 01m
Fri 11/1310:25 pm -
2 stops33h 13m
Deal found 10/7![Multiple Airlines logo]()
$348
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:00 am -
1 stop4h 42m
Fri 10/302:26 pm -
1 stop7h 53m
Deal found 10/8![American Airlines logo]()
$354
This Southwest deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:45 am -
2 stops9h 20m
Tue 12/17:00 am -
2 stops10h 10m
Deal found 10/6![Southwest logo]()
$354
Best flights from South Carolina to Des MoinesDiscover carefully curated flight deals from South Carolina to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 10, 2026.
Discover carefully curated flight deals from South Carolina to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 10, 2026.
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/97:05 am -
1 stop7h 30m
Sat 12/1211:09 am -
1 stop4h 36m
Deal found 10/8![American Airlines logo]()
$269
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:30 am -
1 stop7h 09m
Sat 12/121:15 pm -
2 stops9h 25m
Deal found 10/8![United Airlines logo]()
$274
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/311:33 am -
1 stop4h 43m
Tue 11/1011:36 am -
1 stop4h 34m
Deal found 10/6![Delta logo]()
$327
This Kiwi.com deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:00 am -
2 stops36h 02m
Sun 10/256:37 pm -
1 stop25h 24m
Deal found 10/6![Multiple Airlines logo]()
$339
This Southwest deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:45 am -
2 stops9h 20m
Tue 12/17:00 am -
2 stops10h 10m
Deal found 10/6![Southwest logo]()
$354
This American Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/68:32 pm -
1 stop4h 25m
Fri 11/137:23 am -
1 stop7h 01m
Deal found 10/7![American Airlines logo]()
$343
This Kiwi.com deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/63:14 pm -
1 stop8h 01m
Fri 11/1310:25 pm -
2 stops33h 13m
Deal found 10/7![Multiple Airlines logo]()
$348
This United Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/283:35 pm -
1 stop7h 20m
Sat 10/319:36 am -
1 stop7h 28m
Deal found 10/5![United Airlines logo]()
$369
This Southwest deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/1210:55 am -
2 stops10h 45m
Fri 1/155:20 am -
2 stops6h 35m
Deal found 10/10![Southwest logo]()
$375
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/249:58 am -
1 stop5h 33m
Sat 10/317:29 am -
1 stop7h 51m
Deal found 10/9![American Airlines logo]()
$354
This Delta deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:30 am -
1 stop5h 12m
Tue 10/2711:27 am -
1 stop4h 08m
Deal found 10/5![Delta logo]()
$393
This Southwest deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/47:05 am -
2 stops8h 10m
Thu 11/56:40 am -
2 stops15h 20m
Deal found 10/7![Southwest logo]()
$387
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:30 pm -
1 stop4h 28m
Fri 10/302:26 pm -
1 stop7h 53m
Deal found 10/9![American Airlines logo]()
$354
This United Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1012:18 pm -
1 stop7h 58m
Thu 11/128:00 am -
1 stop4h 56m
Deal found 10/10![United Airlines logo]()
$401
This United Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/312:22 pm -
2 stops11h 37m
Tue 11/106:05 am -
2 stops7h 12m
Deal found 10/6![United Airlines logo]()
$407
This Delta deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:40 am -
1 stop6h 02m
Fri 11/66:00 am -
1 stop5h 13m
Deal found 10/5![Delta logo]()
$448
This American Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/31:45 pm -
2 stops9h 51m
Tue 11/103:31 pm -
1 stop6h 54m
Deal found 10/6![American Airlines logo]()
$373
This Southwest deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/278:15 am -
2 stops15h 50m
Wed 12/27:00 am -
2 stops10h 10m
Deal found 10/6![Southwest logo]()
$429
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/710:20 am -
1 stop4h 51m
Sat 4/108:00 am -
1 stop5h 12m
Deal found 10/9![United Airlines logo]()
$415
This American Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/123:32 pm -
2 stops9h 01m
Fri 1/158:07 am -
1 stop3h 58m
Deal found 10/10![American Airlines logo]()
$379
This Southwest deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/278:15 am -
2 stops15h 50m
Tue 12/17:00 am -
2 stops10h 10m
Deal found 10/5![Southwest logo]()
$435
This United Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:20 am -
1 stop5h 12m
Tue 12/11:15 pm -
2 stops9h 25m
Deal found 10/6![United Airlines logo]()
$426
This American Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/234:34 pm -
2 stops8h 40m
Tue 10/277:00 am -
1 stop4h 56m
Deal found 10/5![American Airlines logo]()
$398
This Southwest deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/171:40 pm -
2 stops10h 20m
Wed 12/305:10 am -
2 stops8h 10m
Deal found 10/6![Southwest logo]()
$456
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:37 pm -
1 stop5h 18m
Sat 10/3111:23 am -
1 stop4h 37m
Deal found 10/7![United Airlines logo]()
$439
This American Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:30 pm -
1 stop4h 28m
Sun 11/16:00 am -
1 stop6h 20m
Deal found 10/5![American Airlines logo]()
$401
This Southwest deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/510:45 am -
2 stops12h 20m
Fri 11/66:40 am -
2 stops15h 20m
Deal found 10/5![Southwest logo]()
$476
This United Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:20 am -
1 stop5h 12m
Sun 11/86:05 am -
2 stops7h 11m
Deal found 10/6![United Airlines logo]()
$448
This United Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/511:27 am -
2 stops11h 28m
Mon 11/91:27 pm -
2 stops19h 54m
Deal found 10/6![United Airlines logo]()
$613
This Delta deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2412:23 pm -
2 stops9h 17m
Mon 10/266:00 am -
2 stops8h 30m
Deal found 10/8![Delta logo]()
$1,008
Last-minute flights from South Carolina to Des MoinesDiscover last-minute flight deals from South Carolina to Des Moines. Data last updated October 10, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Des Moines. Data last updated October 10, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:00 am -
2 stops36h 02m
Sun 10/256:37 pm -
1 stop25h 24m
Deal found 10/6![Multiple Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:00 am -
1 stop4h 42m
Fri 10/302:26 pm -
1 stop7h 53m
Deal found 10/8![American Airlines logo]()
$354
This American Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/268:12 pm -
1 stop4h 46m
Wed 10/287:08 am -
1 stop5h 23m
Deal found 10/6![American Airlines logo]()
$346
This Southwest deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:50 am -
1 stop4h 40m
Fri 10/305:10 am -
2 stops9h 10m
Deal found 10/6![Southwest logo]()
$368
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/311:33 am -
1 stop4h 43m
Tue 11/1011:36 am -
1 stop4h 34m
Deal found 10/6![Delta logo]()
$327
This American Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/45:17 pm -
1 stop6h 48m
Thu 11/57:23 am -
1 stop7h 44m
Deal found 10/7![American Airlines logo]()
$341
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:42 pm -
1 stop6h 44m
Sun 11/83:31 pm -
1 stop5h 27m
Deal found 10/8![American Airlines logo]()
$343
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/68:32 pm -
1 stop4h 25m
Fri 11/137:23 am -
1 stop7h 01m
Deal found 10/8![American Airlines logo]()
$343
This Kiwi.com deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/63:14 pm -
1 stop8h 01m
Fri 11/1310:25 pm -
2 stops33h 13m
Deal found 10/7![Multiple Airlines logo]()
$348
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:40 am -
1 stop6h 04m
Mon 11/162:59 pm -
1 stop4h 02m
Deal found 10/6![Delta logo]()
$269
This American Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:42 pm -
1 stop6h 44m
Mon 11/163:31 pm -
1 stop5h 27m
Deal found 10/6![American Airlines logo]()
$306
This Southwest deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:45 am -
2 stops9h 20m
Tue 12/17:00 am -
2 stops10h 10m
Deal found 10/6![Southwest logo]()
$354
One-way flights from South Carolina to Des MoinesSearch for one-way flight options from South Carolina to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 10, 2026.
Search for one-way flight options from South Carolina to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 10, 2026.
This Delta deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/57:00 am -
1 stop4h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![Delta logo]()
$135
This United Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/69:50 am -
2 stops11h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![United Airlines logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/153:04 pm -
1 stop7h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![Allegiant Air logo]()
$144
This Kiwi.com deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/183:15 pm -
1 stop8h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/8![Allegiant Air logo]()
$182
This United Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/316:00 am -
1 stop5h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![United Airlines logo]()
$185
This American Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/43:33 pm -
1 stop8h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![American Airlines logo]()
$188
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/53:23 pm -
2 stops8h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![United Airlines logo]()
$190
This Southwest deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/44:00 pm -
2 stops8h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![Southwest logo]()
$193
This Southwest deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:55 am -
2 stops10h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![Southwest logo]()
$214
This Southwest deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/186:45 am -
2 stops9h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/8![Southwest logo]()
$214
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/47:00 am -
1 stop4h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![Delta logo]()
$219
This United Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/16:39 pm -
1 stop5h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![United Airlines logo]()
$222
Find flight deals from South Carolina to Des Moines
Keep the following information in mind while searching for South Carolina to Des Moines flight deals. Data was last updated October 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $269 (United Airlines) |
One-way from | $135 (Delta) |
Popular in | July |
Cheapest in | February |
Average price | $582 |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 10, 2026.
Use the filters below to find and compare flights from South Carolina to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Wed 1/6
4:30 pm-10:29 pm
1 stop6h 59m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$135
Quickest round-trip
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Tue 1/5
7:00 am-10:18 am
1 stop4h 18m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$135
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Wed 1/6
9:50 am-8:38 pm
2 stops11h 48m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$140
GreenvilleDes Moines
GSP Greenville - DSM Des Moines
GSPDSM
Greenville
Fri 12/18
3:15 pm-11:01 pm
1 stop8h 46m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$182
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Thu 12/31
6:00 am-10:46 am
1 stop5h 46m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$185
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Tue 1/5
3:23 pm-11:14 pm
2 stops8h 51m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$190
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Tue 11/24
5:55 am-3:05 pm
2 stops10h 10m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$214
GreenvilleDes Moines
GSP Greenville - DSM Des Moines
GSPDSM
Greenville
Fri 12/18
6:45 am-3:05 pm
2 stops9h 20m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$214
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Mon 1/4
10:05 am-9:23 pm
2 stops12h 18m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$264
GreenvilleDes Moines
GSP Greenville - DSM Des Moines
GSPDSM
Greenville
Wed 12/9
7:05 am-1:35 pm
1 stop7h 30m
Des Moines
Sat 12/12
11:09 am-4:45 pm
1 stop4h 36m
$269
Showing 1-10 of 49 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from South Carolina with our price prediction graph.
GSP-DSM
CAE-DSM
CHS-DSM
MYR-DSM
HHH-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Des Moines
USSC-DSM
GSP-DSM
CAE-DSM
CHS-DSM
MYR-DSM
What is the cheapest month to book a flight from South Carolina to Des Moines?
Currently, April is the cheapest month in which you can book a flight from South Carolina to Des Moines (average of $335). Flying from South Carolina to Des Moines in March is currently the most expensive (average of $695). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from South Carolina to Des Moines?
Airfare is below average for this route at the moment.
South Carolina to Des Moines flights typically cost between $418 and $532 in January.The cheapest round-trip price found within the last 5 days was $269 on United Airlines (Jan 16-Jan 18).
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
West Des Moines
Ames
Johnston
Boone
Norwalk
Ankeny
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for South Carolina to Des Moines
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Complete your trip
Complete your trip to Des Moines by adding a car rental and/or hotel reservation to your travel itinerary.
Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 10, 2026.
Search flights from South Carolina to Des Moines by cabin class
Find flights from South Carolina to Des Moines, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Des Moines flights
Browse other South Carolina and Des Moines flight options. Last updated on October 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
South Carolina to Des Moines flights
Consider these flights traveling from South Carolina to Des Moines.
Top 3 airlines flying from South Carolina to Des Moines
Discover the top 3 airlines that operate flights from South Carolina to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$233 | Average$413 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$280 | Average$390 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$294 | Average$395 | FlexibilityNo cancel fee | On-timeN/A |