To save up to 58% on this flight, we recommend booking at least 25 days prior to travel. The price may fluctuate and will likely increase closer to your departure date. Users on Cheapflights have found tickets from South Carolina to Des Moines from $363 1-2 weeks out and tickets from $501 for flights departing within the next 72 hours.
Flights from South Carolina to Des Moines lean towards being more expensive in December. Prices are generally better when you fly from South Carolina to Des Moines in April, with the cheapest ticket starting at $199.
The chart below displays the airlines Cheapflights users traveling from South Carolina to Des Moines choose most often. Cheapest and average prices are based on aggregated data from the past 12 months.
||$107||$296||No cancel fee||69%|
||$173||$386||No cancel fee||71%|
||$140||$404||No cancel fee||N/A|