$135+ Cheap flights from South Carolina to Des Moines (DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/14. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
Aug 18 — Aug 251
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from South Carolina to Des MoinesExplore the most affordable flight options available from South Carolina to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 19, 2026.
Explore the most affordable flight options available from South Carolina to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 19, 2026.
This American Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/128:12 am
CAE
- DSM
1 stop4h 42m
American Airlines
Sat 9/195:57 pm
DSM
- CAE
1 stop5h 02m
American Airlines
Deal found 7/16![American Airlines logo]()
$285
This Kiwi.com deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:59 pm
GSP
- DSM
1 stop27h 09m
Multiple Airlines
Mon 9/1410:24 am
DSM
- GSP
1 stop7h 41m
Multiple Airlines
Deal found 7/19![Multiple Airlines logo]()
$287
This United Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/125:38 pm
CAE
- DSM
1 stop6h 17m
United Airlines
Sat 9/196:24 am
DSM
- CAE
2 stops6h 55m
United Airlines
Deal found 7/17![United Airlines logo]()
$290
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/228:51 pm
CLT
- DSM
1 stop24h 03m
Multiple Airlines
Mon 8/315:28 pm
DSM
- CLT
1 stop13h 33m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/268:51 pm
CLT
- DSM
1 stop24h 03m
Multiple Airlines
Mon 8/315:28 pm
DSM
- CLT
1 stop13h 33m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/92:53 pm
CHS
- DSM
2 stops33h 21m
Multiple Airlines
Tue 8/1812:53 pm
DSM
- CHS
1 stop19h 15m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$310
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/228:51 pm
CLT
- DSM
1 stop24h 03m
Multiple Airlines
Fri 8/282:53 pm
DSM
- CLT
1 stop16h 08m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$313
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/177:59 pm
GSP
- DSM
1 stop27h 09m
Multiple Airlines
Wed 9/2312:44 pm
DSM
- GSP
1 stop25h 05m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$315
This American Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/58:45 am
SAV
- DSM
1 stop5h 18m
American Airlines
Fri 9/118:03 am
DSM
- SAV
1 stop4h 46m
American Airlines
Deal found 7/19![American Airlines logo]()
$316
This American Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/58:45 am
SAV
- DSM
1 stop5h 18m
American Airlines
Mon 9/78:10 am
DSM
- SAV
1 stop4h 21m
American Airlines
Deal found 7/16![American Airlines logo]()
$317
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/64:08 pm
CHS
- DSM
1 stop8h 36m
American Airlines
Thu 8/134:13 pm
DSM
- CHS
1 stop5h 37m
American Airlines
Deal found 7/15![American Airlines logo]()
$317
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:20 am
GSP
- DSM
1 stop5h 11m
United Airlines
Wed 9/233:22 pm
DSM
- GSP
1 stop4h 56m
United Airlines
Deal found 7/15![United Airlines logo]()
$317
Best flights from South Carolina to Des MoinesDiscover carefully curated flight deals from South Carolina to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 19, 2026.
Discover carefully curated flight deals from South Carolina to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 19, 2026.
This United Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/125:38 pm
CAE
- DSM
1 stop6h 17m
United Airlines
Sat 9/196:24 am
DSM
- CAE
2 stops6h 55m
United Airlines
Deal found 7/17![United Airlines logo]()
$290
This American Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/308:08 am
MYR
- DSM
1 stop4h 56m
American Airlines
Mon 10/56:00 am
DSM
- MYR
1 stop4h 40m
American Airlines
Deal found 7/14![American Airlines logo]()
$317
This Southwest deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:40 am
SAV
- DSM
1 stop4h 50m
Southwest
Fri 9/115:40 am
DSM
- SAV
2 stops8h 55m
Southwest
Deal found 7/19![Southwest logo]()
$322
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/177:59 pm
GSP
- DSM
1 stop27h 09m
Multiple Airlines
Wed 9/2312:44 pm
DSM
- GSP
1 stop25h 05m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$323
This Delta deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:58 pm
MYR
- DSM
1 stop4h 36m
Delta
Sat 10/314:01 pm
DSM
- MYR
1 stop4h 42m
Delta
Deal found 7/19![Delta logo]()
$337
This United Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:15 am
CAE
- DSM
1 stop7h 19m
United Airlines
Sat 10/246:00 am
DSM
- CAE
2 stops7h 26m
United Airlines
Deal found 7/16![United Airlines logo]()
$290
This Southwest deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/311:15 pm
CHS
- DSM
2 stops9h 55m
Southwest
Wed 9/27:15 am
DSM
- CHS
2 stops10h 05m
Southwest
Deal found 7/15![Southwest logo]()
$327
This Delta deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:08 pm
CAE
- DSM
1 stop5h 29m
Delta
Mon 8/176:35 pm
DSM
- CAE
1 stop4h 19m
Delta
Deal found 7/18![Delta logo]()
$354
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:20 am
GSP
- DSM
1 stop5h 11m
United Airlines
Wed 9/236:24 am
DSM
- GSP
2 stops7h 39m
United Airlines
Deal found 7/15![United Airlines logo]()
$322
This Southwest deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:40 am
MYR
- DSM
1 stop5h 30m
Southwest
Mon 10/57:10 pm
DSM
- MYR
2 stops13h 35m
Southwest
Deal found 7/15![Southwest logo]()
$328
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:01 pm
MYR
- DSM
1 stop7h 12m
American Airlines
Sun 10/46:00 am
DSM
- MYR
1 stop7h 37m
American Airlines
Deal found 7/15![American Airlines logo]()
$362
This Delta deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/45:44 pm
CAE
- DSM
1 stop5h 53m
Delta
Mon 9/74:11 pm
DSM
- CAE
1 stop6h 43m
Delta
Deal found 7/19![Delta logo]()
$354
This Southwest deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/17:50 am
MYR
- DSM
1 stop5h 00m
Southwest
Mon 9/145:40 am
DSM
- MYR
2 stops6h 30m
Southwest
Deal found 7/17![Southwest logo]()
$342
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1911:04 am
SAV
- DSM
1 stop5h 29m
American Airlines
Sun 11/224:03 pm
DSM
- SAV
1 stop7h 03m
American Airlines
Deal found 7/15![American Airlines logo]()
$382
This Delta deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/185:05 pm
SAV
- DSM
1 stop6h 32m
Delta
Mon 8/242:54 pm
DSM
- SAV
1 stop6h 41m
Delta
Deal found 7/19![Delta logo]()
$355
This United Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/188:10 am
SAV
- DSM
2 stops9h 09m
United Airlines
Mon 8/248:00 am
DSM
- SAV
1 stop6h 04m
United Airlines
Deal found 7/19![United Airlines logo]()
$360
This Delta deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:45 pm
CHS
- DSM
1 stop4h 52m
Delta
Tue 8/186:55 am
DSM
- CHS
1 stop6h 22m
Delta
Deal found 7/17![Delta logo]()
$355
This Southwest deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/198:05 am
CLT
- DSM
1 stop4h 45m
Southwest
Wed 8/262:40 pm
DSM
- CLT
1 stop5h 30m
Southwest
Deal found 7/17![Southwest logo]()
$355
This United Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/308:00 am
CHS
- DSM
1 stop7h 15m
United Airlines
Fri 10/23:11 pm
DSM
- CHS
1 stop5h 22m
United Airlines
Deal found 7/14![United Airlines logo]()
$362
This Southwest deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/153:25 pm
CLT
- DSM
1 stop5h 00m
Southwest
Sat 8/2212:10 pm
DSM
- CLT
1 stop5h 00m
Southwest
Deal found 7/18![Southwest logo]()
$355
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/188:10 am
SAV
- DSM
1 stop7h 06m
United Airlines
Sun 8/236:00 am
DSM
- SAV
2 stops7h 38m
United Airlines
Deal found 7/15![United Airlines logo]()
$367
This Delta deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:35 am
AGS
- DSM
1 stop6h 07m
Delta
Sat 10/2411:27 am
DSM
- AGS
1 stop4h 39m
Delta
Deal found 7/16![Delta logo]()
$379
This American Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/411:03 am
CLT
- DSM
Nonstop2h 21m
American Airlines
Mon 9/75:10 pm
DSM
- CLT
Nonstop2h 38m
American Airlines
Deal found 7/19![American Airlines logo]()
$471
This Southwest deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:50 am
CLT
- DSM
2 stops8h 05m
Southwest
Tue 8/252:40 pm
DSM
- CLT
1 stop5h 30m
Southwest
Deal found 7/19![Southwest logo]()
$360
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:20 am
GSP
- DSM
1 stop5h 11m
United Airlines
Wed 9/238:00 am
DSM
- GSP
2 stops10h 45m
United Airlines
Deal found 7/15![United Airlines logo]()
$367
This Delta deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:00 pm
SAV
- DSM
1 stop6h 34m
Delta
Mon 11/166:30 pm
DSM
- SAV
1 stop4h 29m
Delta
Deal found 7/18![Delta logo]()
$381
This Southwest deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:45 am
SAV
- DSM
2 stops8h 10m
Southwest
Mon 8/245:40 am
DSM
- SAV
2 stops8h 55m
Southwest
Deal found 7/19![Southwest logo]()
$366
This United Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:25 am
CAE
- DSM
2 stops10h 44m
United Airlines
Sat 10/318:00 am
DSM
- CAE
1 stop4h 37m
United Airlines
Deal found 7/16![United Airlines logo]()
$370
This Delta deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/96:15 am
CHS
- DSM
1 stop5h 28m
Delta
Wed 8/195:40 am
DSM
- CHS
1 stop5h 14m
Delta
Deal found 7/17![Delta logo]()
$391
This Southwest deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2011:30 am
CHS
- DSM
2 stops10h 45m
Southwest
Sat 8/225:30 am
DSM
- CHS
2 stops10h 10m
Southwest
Deal found 7/18![Southwest logo]()
$366
Last-minute flights from South Carolina to Des MoinesDiscover last-minute flight deals from South Carolina to Des Moines. Data last updated July 19, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Des Moines. Data last updated July 19, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/64:08 pm
CHS
- DSM
1 stop8h 36m
American Airlines
Thu 8/134:13 pm
DSM
- CHS
1 stop5h 37m
American Airlines
Deal found 7/15![American Airlines logo]()
$317
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/92:53 pm
CHS
- DSM
2 stops33h 21m
Multiple Airlines
Tue 8/1812:53 pm
DSM
- CHS
1 stop19h 15m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$310
This Delta deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:08 pm
CAE
- DSM
1 stop5h 29m
Delta
Mon 8/176:35 pm
DSM
- CAE
1 stop4h 19m
Delta
Deal found 7/18![Delta logo]()
$354
This Southwest deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:30 pm
CLT
- DSM
1 stop4h 40m
Southwest
Wed 8/192:40 pm
DSM
- CLT
1 stop5h 30m
Southwest
Deal found 7/14![Southwest logo]()
$321
This Delta deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/185:05 pm
SAV
- DSM
1 stop6h 32m
Delta
Mon 8/242:54 pm
DSM
- SAV
1 stop6h 41m
Delta
Deal found 7/19![Delta logo]()
$355
This Southwest deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/196:50 am
CLT
- DSM
2 stops8h 05m
Southwest
Wed 8/267:15 am
DSM
- CLT
2 stops10h 45m
Southwest
Deal found 7/15![Southwest logo]()
$331
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/228:51 pm
CLT
- DSM
1 stop24h 03m
Multiple Airlines
Mon 8/315:28 pm
DSM
- CLT
1 stop13h 33m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/228:51 pm
CLT
- DSM
1 stop24h 03m
Multiple Airlines
Fri 8/282:53 pm
DSM
- CLT
1 stop16h 08m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$313
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/228:51 pm
CLT
- DSM
1 stop24h 03m
Multiple Airlines
Thu 8/271:55 pm
DSM
- CLT
1 stop17h 56m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$322
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/228:51 pm
CLT
- DSM
1 stop24h 03m
Multiple Airlines
Sun 8/301:55 pm
DSM
- CLT
1 stop17h 56m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$327
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/268:51 pm
CLT
- DSM
1 stop24h 03m
Multiple Airlines
Mon 8/315:28 pm
DSM
- CLT
1 stop13h 33m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$309
This Southwest deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/317:00 am
CHS
- DSM
1 stop5h 25m
Southwest
Wed 9/27:15 am
DSM
- CHS
2 stops11h 00m
Southwest
Deal found 7/16![Southwest logo]()
$322
One-way flights from South Carolina to Des MoinesSearch for one-way flight options from South Carolina to Des Moines. Find affordable one-way fares based on user searches. Data last updated July 19, 2026.
Search for one-way flight options from South Carolina to Des Moines. Find affordable one-way fares based on user searches. Data last updated July 19, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/145:38 pm
CLT
- DSM
1 stop24h 14m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$135
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/253:13 pm
CHS
- DSM
2 stops46h 52m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$143
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/165:33 pm
CLT
- DSM
1 stop27h 24m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$152
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/64:53 pm
SAV
- DSM
1 stop5h 29m
United Airlines
Deal found 7/15![United Airlines logo]()
$159
This American Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:00 am
CHS
- DSM
1 stop7h 25m
American Airlines
Deal found 7/16![American Airlines logo]()
$159
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/121:38 pm
CLT
- DSM
3 stops34h 41m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$159
This Kiwi.com deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:38 pm
CLT
- DSM
1 stop30h 32m
Multiple Airlines
Deal found 7/19![Multiple Airlines logo]()
$160
This Southwest deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/157:55 am
CLT
- DSM
1 stop4h 35m
Southwest
Deal found 7/17![Southwest logo]()
$161
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/179:22 am
CLT
- DSM
1 stop11h 35m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$163
This Southwest deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:35 am
CHS
- DSM
2 stops8h 10m
Southwest
Deal found 7/16![Southwest logo]()
$164
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/610:05 am
SAV
- DSM
2 stops12h 26m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$179
This Kiwi.com deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/63:40 pm
GSP
- DSM
2 stops26h 37m
Multiple Airlines
Deal found 7/17![Multiple Airlines logo]()
$194
Find flight deals from South Carolina to Des Moines
Keep the following information in mind while searching for South Carolina to Des Moines flight deals. Data was last updated July 19, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $285 (American Airlines) |
One-way from | $135 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 19, 2026.
Use the filters below to find and compare flights from South Carolina to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ColumbiaDes Moines
CAE - DSM
CAEDSM
Columbia Metropolitan
Sat 9/12
5:38 pm-10:55 pm
1 stop6h 17m
Des Moines
Sat 9/19
6:24 am-2:19 pm
2 stops6h 55m
$290
ColumbiaDes Moines
CAE - DSM
CAEDSM
Columbia Metropolitan
Wed 10/21
6:15 am-12:34 pm
1 stop7h 19m
Des Moines
Sat 10/24
6:00 am-2:26 pm
2 stops7h 26m
$290
Myrtle BeachDes Moines
MYR - DSM
MYRDSM
Myrtle Beach Intl
Wed 9/30
8:08 am-12:04 pm
1 stop4h 56m
Des Moines
Mon 10/5
6:00 am-11:40 am
1 stop4h 40m
$317
SavannahDes Moines
SAV - DSM
SAVDSM
Savannah/Hilton Head
Sat 9/5
7:40 am-11:30 am
1 stop4h 50m
Des Moines
Fri 9/11
5:40 am-3:35 pm
2 stops8h 55m
$322
GreenvilleDes Moines
GSP - DSM
GSPDSM
Greenville
Thu 9/17
6:20 am-10:31 am
1 stop5h 11m
Des Moines
Wed 9/23
6:24 am-3:03 pm
2 stops7h 39m
$322
GreenvilleDes Moines
GSP - DSM
GSPDSM
Greenville
Thu 9/17
7:59 pm-10:08 pm
1 stop27h 09m
Des Moines
Wed 9/23
12:44 pm-2:49 pm
1 stop25h 05m
$323
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Mon 8/31
1:15 pm-10:10 pm
2 stops9h 55m
Des Moines
Wed 9/2
7:15 am-6:20 pm
2 stops10h 05m
$327
Myrtle BeachDes Moines
MYR - DSM
MYRDSM
Myrtle Beach Intl
Thu 10/1
6:40 am-11:10 am
1 stop5h 30m
Des Moines
Mon 10/5
7:10 pm-9:45 am
2 stops13h 35m
$328
Myrtle BeachDes Moines
MYR - DSM
MYRDSM
Myrtle Beach Intl
Tue 10/27
6:58 pm-10:34 pm
1 stop4h 36m
Des Moines
Sat 10/31
4:01 pm-9:43 pm
1 stop4h 42m
$337
Myrtle BeachDes Moines
MYR - DSM
MYRDSM
Myrtle Beach Intl
Tue 9/1
7:50 am-11:50 am
1 stop5h 00m
Des Moines
Mon 9/14
5:40 am-1:10 pm
2 stops6h 30m
$342
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from South Carolina with our price prediction graph.
SAV-DSM
CHS-DSM
CLT-DSM
GSP-DSM
CAE-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Des Moines
USSC-DSM
SAV-DSM
CHS-DSM
CLT-DSM
GSP-DSM
What is the cheapest month to book a flight from South Carolina to Des Moines?
Currently, April is the cheapest month in which you can book a flight from South Carolina to Des Moines (average of $328). Flying from South Carolina to Des Moines in March is currently the most expensive (average of $695). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Ames
Clive
Johnston
Boone
West Des Moines
Ankeny
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for South Carolina to Des Moines
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Complete your trip
Complete your trip to Des Moines by adding a car rental and/or hotel reservation to your travel itinerary.
Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 19, 2026.
Search flights from South Carolina to Des Moines by cabin class
Find flights from South Carolina to Des Moines, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Des Moines flights
Browse other South Carolina and Des Moines flight options. Last updated on July 19, 2026.
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Check out other popular destinations found by fellow travelers in 2026
South Carolina to Des Moines flights
Consider these flights traveling from South Carolina to Des Moines.
Top 3 airlines flying from South Carolina to Des Moines
Discover the top 3 airlines that operate flights from South Carolina to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 19, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$140 | Average$389 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$236 | Average$410 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$326 | Average$543 | FlexibilityNo cancel fee | On-time69% |