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Des Moines

$125+ Cheap flights from South Carolina to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/30. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
Jun 28 — Jul 51
Sun 6/28
Sun 7/5
1 adult, Economy
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Cheap flight deals from South Carolina to Des Moines

Cheapest flights from South Carolina to Des Moines
Explore the most affordable flight options available from South Carolina to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 29, 2026.

This Kiwi.com deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/196:59 pm
GSP
-
DSM
1 stop28h 53m
Allegiant Air
Sat 7/44:59 pm
DSM
-
GSP
1 stop13h 36m
Allegiant Air
Deal found 5/26$270
This Booking.com deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/147:14 pm
CLT
-
DSM
1 stop19h 17m
Frontier
Wed 6/172:16 pm
DSM
-
CLT
1 stop27h 03m
Frontier
Deal found 5/27$282
This Kiwi.com deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/236:41 pm
CLT
-
DSM
1 stop22h 09m
Multiple Airlines
Mon 7/274:40 pm
DSM
-
CLT
1 stop27h 27m
Multiple Airlines
Deal found 5/29$298
This Kiwi.com deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/196:59 pm
GSP
-
DSM
1 stop28h 53m
Allegiant Air
Sun 6/289:27 am
DSM
-
GSP
1 stop21h 07m
Allegiant Air
Deal found 5/26$302
This Southwest deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/101:25 pm
CLT
-
DSM
2 stops10h 20m
Southwest
Tue 6/165:20 am
DSM
-
CLT
1 stop4h 50m
Southwest
Deal found 5/26$307
This Kiwi.com deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/263:21 pm
GSP
-
DSM
1 stop9h 14m
Allegiant Air
Sun 6/289:27 am
DSM
-
GSP
1 stop21h 07m
Allegiant Air
Deal found 5/24$314
This Kiwi.com deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/196:41 pm
CLT
-
DSM
1 stop22h 09m
Multiple Airlines
Fri 7/244:40 pm
DSM
-
CLT
1 stop27h 27m
Multiple Airlines
Deal found 5/29$322
This Southwest deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:30 pm
CLT
-
DSM
1 stop4h 40m
Southwest
Sun 9/133:50 pm
DSM
-
CLT
1 stop4h 20m
Southwest
Deal found 5/27$325
This Kiwi.com deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/196:59 pm
GSP
-
DSM
1 stop28h 53m
Allegiant Air
Wed 7/110:00 am
DSM
-
GSP
1 stop27h 56m
Allegiant Air
Deal found 5/26$330
This United Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1912:59 pm
SAV
-
DSM
1 stop5h 29m
United Airlines
Wed 8/263:20 pm
DSM
-
SAV
1 stop4h 59m
United Airlines
Deal found 5/28$335
This Southwest deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/176:10 am
CHS
-
DSM
1 stop6h 20m
Southwest
Wed 6/243:45 pm
DSM
-
CHS
1 stop4h 40m
Southwest
Deal found 5/26$335
This Southwest deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/87:05 pm
CLT
-
DSM
1 stop5h 25m
Southwest
Thu 6/114:40 pm
DSM
-
CLT
1 stop4h 10m
Southwest
Deal found 5/25$335

Find flight deals from South Carolina to Des Moines

Keep the following information in mind while searching for South Carolina to Des Moines flight deals. Data was last updated May 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$270
(Kiwi.com)

One-way from

$125
(Mytrip)

Popular in

December

Cheapest in

July

Average price

$404
Provider with most accurate pricing for Myrtle Beach Intl-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Des Moines flights.
Search Deals
From South Carolina to Des Moines
Search Deals
One-way flight from South Carolina to Des Moines
Search Deals
Highest demand for flights based on searches. 29% potential increase in price ($171 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($25 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 29, 2026.
Use the filters below to find and compare flights from South Carolina to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

SavannahDes Moines

SAV - DSM

SAVDSM

Savannah/Hilton Head

Wed 8/19

12:59 pm-5:28 pm

1 stop5h 29m

Des Moines

Wed 8/26

3:20 pm-9:19 pm

1 stop4h 59m

$335

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Wed 7/8

8:52 am-1:34 pm

1 stop5h 42m

Des Moines

Wed 7/22

6:37 pm-11:54 pm

1 stop4h 17m

$335

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 6/17

6:00 am-10:43 am

1 stop5h 43m

Des Moines

Tue 6/23

5:35 am-10:44 am

1 stop4h 09m

$335

SavannahDes Moines

SAV - DSM

SAVDSM

Savannah/Hilton Head

Wed 8/19

1:10 pm-9:00 pm

2 stops8h 50m

Des Moines

Wed 8/26

6:10 am-4:25 pm

2 stops9h 15m

$345

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Fri 7/31

7:30 pm-12:09 am

1 stop5h 39m

Des Moines

Tue 8/4

6:33 pm-11:58 pm

1 stop4h 25m

$371

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Sun 6/28

6:21 pm-11:50 pm

1 stop6h 29m

Des Moines

Wed 7/15

1:41 pm-9:43 pm

1 stop7h 02m

$371

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Wed 7/1

5:16 pm-10:31 pm

1 stop6h 15m

Des Moines

Sat 7/4

11:40 am-7:16 pm

1 stop6h 36m

$371

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Wed 6/17

5:44 am-10:43 am

1 stop5h 59m

Des Moines

Fri 7/3

5:00 pm-11:59 pm

1 stop5h 59m

$371

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Fri 7/17

4:34 pm-10:29 pm

1 stop6h 55m

Des Moines

Tue 7/21

5:41 am-10:47 am

1 stop4h 06m

$371

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sat 8/1

10:30 am-9:28 pm

2 stops11h 58m

Des Moines

Tue 8/4

11:23 am-5:00 pm

1 stop4h 37m

$376

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/27

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from South Carolina to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Des Moines

What is the cheapest month to book a flight from South Carolina to Des Moines?

Currently, September is the cheapest month in which you can book a flight from South Carolina to Des Moines (average of $140). Flying from South Carolina to Des Moines in May is currently the most expensive (average of $370). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from South Carolina to Des Moines?

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from South Carolina?

    Des Moines (DSM) is the airport you will fly into if you book a flight from South Carolina to Des Moines. It is only a 3.6 mi journey from Des Moines (DSM) to Des Moines’s city center.

  • How long is the flight from South Carolina to Des Moines?

    United Airlines, Delta, and Southwest can get you from South Carolina to Des Moines in just under 5h 29m. Your travel time can differ by up to 3h 21m. South Carolina and Des Moines are separated by a distance of 945 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from South Carolina to Des Moines?

    When deciding which route to take from South Carolina to Des Moines consider Charlotte Douglas - Des Moines, Greenville - Des Moines or Myrtle Beach Intl - Des Moines as they are the most popular.

  • Can I find deals for flights from South Carolina to Des Moines that include hotel bookings?

    Yes. In addition to deals on South Carolina to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Des Moines.

  • Can I find deals for business class flights from South Carolina to Des Moines?

    Yes. Cheapflights offers flight deals from South Carolina to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Des Moines?

    Currently, September is the cheapest month in which you can book a flight from South Carolina to Des Moines (average of $140). Flying from South Carolina to Des Moines in May is currently the most expensive (average of $370). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Ames
Clive
Boone
West Des Moines
Ankeny

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Alternative routes for South Carolina to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Des Moines

Discover the top 3 airlines that operate flights from South Carolina to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$140Average$388FlexibilityNo cancel feeOn-time71%
DeltaCheapest$236Average$398FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$326Average$626FlexibilityNo cancel feeOn-time69%

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