$102+ Cheap flights from South Carolina to Des Moines (DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/30. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
May 4 — May 111
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from South Carolina to Des MoinesExplore the most affordable flight options available from South Carolina to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 4, 2026.
Explore the most affordable flight options available from South Carolina to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2112:58 pm
CLT
- DSM
1 stop10h 33m
Multiple Airlines
Sun 5/244:41 pm
DSM
- CLT
1 stop16h 22m
Multiple Airlines
Deal found 4/1![Multiple Airlines logo]()
$231
This Kiwi.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/238:56 am
CLT
- DSM
1 stop8h 04m
Multiple Airlines
Sun 4/267:00 am
DSM
- CLT
1 stop27h 20m
Multiple Airlines
Deal found 4/3![Multiple Airlines logo]()
$238
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/168:56 am
CLT
- DSM
1 stop8h 04m
Multiple Airlines
Sun 4/198:30 am
DSM
- CLT
2 stops48h 47m
Multiple Airlines
Deal found 4/2![Multiple Airlines logo]()
$239
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:00 am
CLT
- DSM
1 stop10h 15m
Multiple Airlines
Sun 5/107:45 am
DSM
- CLT
1 stop27h 20m
Multiple Airlines
Deal found 4/2![Multiple Airlines logo]()
$240
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/1511:28 am
MYR
- DSM
1 stop29h 32m
Multiple Airlines
Sun 4/198:30 am
DSM
- MYR
1 stop13h 59m
Multiple Airlines
Deal found 3/31![Multiple Airlines logo]()
$248
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/181:00 pm
CLT
- DSM
1 stop9h 47m
Multiple Airlines
Sun 6/215:02 pm
DSM
- CLT
1 stop15h 55m
Multiple Airlines
Deal found 4/2![Multiple Airlines logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:41 pm
CLT
- DSM
1 stop21h 34m
Multiple Airlines
Thu 5/214:41 pm
DSM
- CLT
1 stop16h 22m
Multiple Airlines
Deal found 3/30![Multiple Airlines logo]()
$260
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/299:54 pm
CLT
- DSM
1 stop25h 12m
Multiple Airlines
Wed 5/62:16 pm
DSM
- CLT
2 stops20h 56m
Multiple Airlines
Deal found 3/30![Multiple Airlines logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/41:00 pm
CLT
- DSM
1 stop9h 27m
Multiple Airlines
Mon 6/84:07 pm
DSM
- CLT
1 stop18h 58m
Multiple Airlines
Deal found 4/1![Multiple Airlines logo]()
$267
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/211:00 pm
CLT
- DSM
1 stop10h 31m
Multiple Airlines
Mon 5/253:57 pm
DSM
- CLT
1 stop21h 14m
Multiple Airlines
Deal found 3/31![Multiple Airlines logo]()
$272
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/284:15 pm
CAE
- DSM
1 stop8h 01m
American Airlines
Tue 5/57:11 am
DSM
- CAE
1 stop8h 40m
American Airlines
Deal found 3/30![American Airlines logo]()
$307
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/225:25 pm
CAE
- DSM
1 stop6h 36m
United Airlines
Sun 10/256:15 am
DSM
- CAE
1 stop6h 57m
United Airlines
Deal found 3/31![United Airlines logo]()
$315
Best flights from South Carolina to Des MoinesDiscover carefully curated flight deals from South Carolina to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 4, 2026.
Discover carefully curated flight deals from South Carolina to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 4, 2026.
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/283:41 pm
CAE
- DSM
2 stops9h 08m
American Airlines
Tue 5/57:11 am
DSM
- CAE
1 stop8h 40m
American Airlines
Deal found 3/30![American Airlines logo]()
$312
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/29:55 am
CAE
- DSM
1 stop5h 00m
Delta
Mon 5/45:45 am
DSM
- CAE
1 stop6h 29m
Delta
Deal found 4/4![Delta logo]()
$322
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/287:00 am
SAV
- DSM
1 stop8h 22m
United Airlines
Wed 5/62:58 pm
DSM
- SAV
1 stop6h 01m
United Airlines
Deal found 3/31![United Airlines logo]()
$335
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/285:00 pm
SAV
- DSM
1 stop6h 10m
Southwest
Wed 5/65:30 am
DSM
- SAV
2 stops11h 55m
Southwest
Deal found 3/31![Southwest logo]()
$340
This Kiwi.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2710:58 am
MYR
- DSM
2 stops22h 55m
Multiple Airlines
Sun 5/317:30 am
DSM
- MYR
1 stop12h 14m
Multiple Airlines
Deal found 4/3![Multiple Airlines logo]()
$408
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/176:00 am
MYR
- DSM
1 stop5h 43m
Delta
Tue 6/236:39 pm
DSM
- MYR
1 stop4h 20m
Delta
Deal found 3/31![Delta logo]()
$335
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:31 am
GSP
- DSM
1 stop5h 39m
American Airlines
Tue 5/122:18 pm
DSM
- GSP
1 stop4h 26m
American Airlines
Deal found 3/30![American Airlines logo]()
$337
This United Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/182:38 pm
CAE
- DSM
2 stops9h 39m
United Airlines
Wed 4/223:21 pm
DSM
- CAE
1 stop5h 00m
United Airlines
Deal found 4/3![United Airlines logo]()
$344
This Southwest deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/294:05 pm
MYR
- DSM
2 stops7h 05m
Southwest
Sat 5/26:40 am
DSM
- MYR
2 stops10h 35m
Southwest
Deal found 4/3![Southwest logo]()
$346
This Delta deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/186:45 am
CAE
- DSM
1 stop5h 20m
Delta
Wed 4/227:28 am
DSM
- CAE
1 stop7h 03m
Delta
Deal found 4/3![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/25:09 am
SAV
- DSM
2 stops9h 09m
American Airlines
Tue 6/91:37 pm
DSM
- SAV
1 stop6h 05m
American Airlines
Deal found 4/3![American Airlines logo]()
$340
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/151:45 pm
MYR
- DSM
2 stops10h 20m
Southwest
Sat 5/165:35 am
DSM
- MYR
1 stop4h 30m
Southwest
Deal found 4/1![Southwest logo]()
$377
This United Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/296:30 am
GSP
- DSM
1 stop5h 14m
United Airlines
Fri 5/13:20 pm
DSM
- GSP
1 stop6h 38m
United Airlines
Deal found 4/3![United Airlines logo]()
$381
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/134:46 pm
CHS
- DSM
1 stop6h 32m
American Airlines
Mon 5/185:01 pm
DSM
- CHS
1 stop5h 05m
American Airlines
Deal found 3/30![American Airlines logo]()
$355
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/11:59 pm
CAE
- DSM
1 stop4h 46m
Delta
Mon 5/45:45 am
DSM
- CAE
1 stop6h 29m
Delta
Deal found 4/4![Delta logo]()
$357
This Southwest deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:25 pm
CLT
- DSM
1 stop4h 45m
Southwest
Sat 5/235:35 am
DSM
- CLT
1 stop5h 00m
Southwest
Deal found 3/30![Southwest logo]()
$387
This United Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:53 pm
CHS
- DSM
1 stop5h 31m
United Airlines
Mon 5/1811:40 am
DSM
- CHS
1 stop6h 59m
United Airlines
Deal found 3/30![United Airlines logo]()
$391
This Delta deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/85:38 am
CAE
- DSM
1 stop6h 30m
Delta
Sun 5/106:41 pm
DSM
- CAE
1 stop4h 08m
Delta
Deal found 4/1![Delta logo]()
$379
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/18:02 am
GSP
- DSM
1 stop6h 09m
American Airlines
Mon 5/45:01 pm
DSM
- GSP
1 stop5h 02m
American Airlines
Deal found 3/31![American Airlines logo]()
$391
This Southwest deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2912:50 pm
GSP
- DSM
2 stops9h 25m
Southwest
Fri 5/17:20 pm
DSM
- GSP
2 stops13h 50m
Southwest
Deal found 4/3![Southwest logo]()
$391
This United Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/282:38 pm
CAE
- DSM
2 stops10h 04m
United Airlines
Tue 5/511:40 am
DSM
- CAE
2 stops11h 19m
United Airlines
Deal found 3/30![United Airlines logo]()
$412
This Delta deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:17 pm
CAE
- DSM
1 stop4h 15m
Delta
Sun 5/106:41 pm
DSM
- CAE
1 stop4h 08m
Delta
Deal found 4/1![Delta logo]()
$379
This Southwest deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/291:45 pm
CLT
- DSM
2 stops9h 25m
Southwest
Wed 5/65:30 am
DSM
- CLT
2 stops11h 15m
Southwest
Deal found 3/30![Southwest logo]()
$393
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/85:00 am
SAV
- DSM
2 stops8h 50m
American Airlines
Mon 5/113:00 pm
DSM
- SAV
1 stop5h 45m
American Airlines
Deal found 4/1![American Airlines logo]()
$396
This United Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/24:21 pm
SAV
- DSM
1 stop8h 23m
United Airlines
Tue 5/55:30 am
DSM
- SAV
1 stop8h 44m
United Airlines
Deal found 3/30![United Airlines logo]()
$426
This Delta deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:03 pm
CHS
- DSM
1 stop5h 29m
Delta
Mon 5/186:41 pm
DSM
- CHS
1 stop4h 18m
Delta
Deal found 4/3![Delta logo]()
$391
This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/155:00 am
CHS
- DSM
2 stops6h 31m
American Airlines
Mon 5/186:00 am
DSM
- CHS
1 stop4h 49m
American Airlines
Deal found 4/2![American Airlines logo]()
$396
This Southwest deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/114:20 pm
CLT
- DSM
2 stops7h 45m
Southwest
Sat 5/165:35 am
DSM
- CLT
2 stops8h 35m
Southwest
Deal found 3/30![Southwest logo]()
$407
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:45 am
GSP
- DSM
1 stop5h 52m
Delta
Sun 5/106:41 pm
DSM
- GSP
1 stop4h 02m
Delta
Deal found 3/30![Delta logo]()
$391
This American Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/712:35 pm
GSP
- DSM
1 stop8h 46m
American Airlines
Sun 5/106:00 am
DSM
- GSP
2 stops7h 11m
American Airlines
Deal found 4/3![American Airlines logo]()
$406
Last-minute flights from South Carolina to Des MoinesDiscover last-minute flight deals from South Carolina to Des Moines. Data last updated April 4, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Des Moines. Data last updated April 4, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/1511:28 am
MYR
- DSM
1 stop29h 32m
Multiple Airlines
Sun 4/198:30 am
DSM
- MYR
1 stop13h 59m
Multiple Airlines
Deal found 3/31![Multiple Airlines logo]()
$248
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/168:56 am
CLT
- DSM
1 stop8h 04m
Multiple Airlines
Sun 4/198:30 am
DSM
- CLT
2 stops48h 47m
Multiple Airlines
Deal found 4/2![Multiple Airlines logo]()
$239
This Kiwi.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/238:56 am
CLT
- DSM
1 stop8h 04m
Multiple Airlines
Sun 4/267:00 am
DSM
- CLT
1 stop27h 20m
Multiple Airlines
Deal found 4/3![Multiple Airlines logo]()
$238
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/284:15 pm
CAE
- DSM
1 stop8h 01m
American Airlines
Tue 5/57:11 am
DSM
- CAE
1 stop8h 40m
American Airlines
Deal found 3/30![American Airlines logo]()
$307
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/287:00 am
SAV
- DSM
1 stop8h 22m
United Airlines
Wed 5/62:58 pm
DSM
- SAV
1 stop6h 01m
United Airlines
Deal found 3/31![United Airlines logo]()
$335
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/299:54 pm
CLT
- DSM
1 stop25h 12m
Multiple Airlines
Wed 5/62:16 pm
DSM
- CLT
2 stops20h 56m
Multiple Airlines
Deal found 3/30![Multiple Airlines logo]()
$261
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/29:55 am
CAE
- DSM
1 stop5h 00m
Delta
Mon 5/45:45 am
DSM
- CAE
1 stop6h 29m
Delta
Deal found 4/4![Delta logo]()
$322
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:00 am
CAE
- DSM
2 stops7h 30m
American Airlines
Mon 5/47:11 am
DSM
- CAE
1 stop8h 40m
American Airlines
Deal found 4/4![American Airlines logo]()
$327
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:00 am
CLT
- DSM
1 stop10h 15m
Multiple Airlines
Sun 5/107:45 am
DSM
- CLT
1 stop27h 20m
Multiple Airlines
Deal found 4/2![Multiple Airlines logo]()
$240
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:41 pm
CLT
- DSM
1 stop21h 34m
Multiple Airlines
Thu 5/214:41 pm
DSM
- CLT
1 stop16h 22m
Multiple Airlines
Deal found 3/30![Multiple Airlines logo]()
$260
This Kiwi.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2112:58 pm
CLT
- DSM
1 stop10h 33m
Multiple Airlines
Sun 5/244:41 pm
DSM
- CLT
1 stop16h 22m
Multiple Airlines
Deal found 4/1![Multiple Airlines logo]()
$231
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/211:00 pm
CLT
- DSM
1 stop10h 31m
Multiple Airlines
Mon 5/253:57 pm
DSM
- CLT
1 stop21h 14m
Multiple Airlines
Deal found 3/31![Multiple Airlines logo]()
$272
One-way flights from South Carolina to Des MoinesSearch for one-way flight options from South Carolina to Des Moines. Find affordable one-way fares based on user searches. Data last updated April 4, 2026.
Search for one-way flight options from South Carolina to Des Moines. Find affordable one-way fares based on user searches. Data last updated April 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/308:56 am
CLT
- DSM
1 stop14h 10m
Multiple Airlines
Deal found 3/31![Multiple Airlines logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/299:54 pm
CLT
- DSM
1 stop25h 12m
Multiple Airlines
Deal found 4/2![Multiple Airlines logo]()
$110
This Trip.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/159:54 pm
CLT
- DSM
1 stop19h 06m
Multiple Airlines
Deal found 4/3![Multiple Airlines logo]()
$115
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/281:00 pm
CLT
- DSM
1 stop10h 31m
Multiple Airlines
Deal found 3/31![Multiple Airlines logo]()
$116
This Kiwi.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/410:58 am
CLT
- DSM
1 stop11h 29m
Multiple Airlines
Deal found 4/3![Multiple Airlines logo]()
$121
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/277:13 pm
CLT
- DSM
1 stop28h 39m
Multiple Airlines
Deal found 3/31![Multiple Airlines logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/3110:58 am
CLT
- DSM
1 stop12h 33m
Multiple Airlines
Deal found 4/1![Multiple Airlines logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:35 pm
CLT
- DSM
1 stop22h 40m
Multiple Airlines
Deal found 4/3![Multiple Airlines logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/63:44 pm
CHS
- DSM
1 stop17h 53m
Multiple Airlines
Deal found 3/31![Multiple Airlines logo]()
$154
This Delta deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:42 am
GSP
- DSM
1 stop6h 23m
Delta
Deal found 4/2![Delta logo]()
$168
This Delta deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:00 am
MYR
- DSM
1 stop5h 14m
Delta
Deal found 4/2![Delta logo]()
$168
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/68:16 pm
GSP
- DSM
1 stop4h 33m
American Airlines
Deal found 3/30![American Airlines logo]()
$169
Find flight deals from South Carolina to Des Moines
Keep the following information in mind while searching for South Carolina to Des Moines flight deals. Data was last updated April 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $231 (Kiwi.com) |
One-way from | $102 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 4, 2026.
Use the filters below to find and compare flights from South Carolina to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ColumbiaDes Moines
CAE - DSM
CAEDSM
Columbia Metropolitan
Tue 4/28
3:41 pm-11:49 pm
2 stops9h 08m
Des Moines
Tue 5/5
7:11 am-4:51 pm
1 stop8h 40m
$312
ColumbiaDes Moines
CAE - DSM
CAEDSM
Columbia Metropolitan
Sat 5/2
9:55 am-1:55 pm
1 stop5h 00m
Des Moines
Mon 5/4
5:45 am-1:14 pm
1 stop6h 29m
$322
SavannahDes Moines
SAV - DSM
SAVDSM
Savannah/Hilton Head
Tue 4/28
7:00 am-2:22 pm
1 stop8h 22m
Des Moines
Wed 5/6
2:58 pm-9:59 pm
1 stop6h 01m
$335
Myrtle BeachDes Moines
MYR - DSM
MYRDSM
Myrtle Beach Intl
Wed 6/17
6:00 am-10:43 am
1 stop5h 43m
Des Moines
Tue 6/23
6:39 pm-11:59 pm
1 stop4h 20m
$335
GreenvilleDes Moines
GSP - DSM
GSPDSM
Greenville
Sat 5/9
6:31 am-11:10 am
1 stop5h 39m
Des Moines
Tue 5/12
2:18 pm-7:44 pm
1 stop4h 26m
$337
ColumbiaDes Moines
CAE - DSM
CAEDSM
Columbia Metropolitan
Sat 4/18
6:45 am-11:05 am
1 stop5h 20m
Des Moines
Wed 4/22
7:28 am-3:31 pm
1 stop7h 03m
$339
SavannahDes Moines
SAV - DSM
SAVDSM
Savannah/Hilton Head
Tue 4/28
5:00 pm-10:10 pm
1 stop6h 10m
Des Moines
Wed 5/6
5:30 am-6:25 pm
2 stops11h 55m
$340
SavannahDes Moines
SAV - DSM
SAVDSM
Savannah/Hilton Head
Tue 6/2
5:09 am-1:18 pm
2 stops9h 09m
Des Moines
Tue 6/9
1:37 pm-8:42 pm
1 stop6h 05m
$340
ColumbiaDes Moines
CAE - DSM
CAEDSM
Columbia Metropolitan
Sat 4/18
2:38 pm-11:17 pm
2 stops9h 39m
Des Moines
Wed 4/22
3:21 pm-9:21 pm
1 stop5h 00m
$344
Myrtle BeachDes Moines
MYR - DSM
MYRDSM
Myrtle Beach Intl
Wed 4/29
4:05 pm-10:10 pm
2 stops7h 05m
Des Moines
Sat 5/2
6:40 am-6:15 pm
2 stops10h 35m
$346
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from South Carolina with our price prediction graph.
CLT-DSM
MYR-DSM
CAE-DSM
CHS-DSM
GSP-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Des Moines
USSC-DSM
CLT-DSM
MYR-DSM
CAE-DSM
CHS-DSM
What is the cheapest month to book a flight from South Carolina to Des Moines?
Currently, September is the cheapest month in which you can book a flight from South Carolina to Des Moines (average of $162). Flying from South Carolina to Des Moines in April is currently the most expensive (average of $320). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SC to DSM?
Find hourly flight availability from South Carolina to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 4, 2026.
It’s typically best to fly out from South Carolina to Des Moines in the afternoon. Doing so could potentially save you 40% on the flight price compared to flying in the evening, which is usually more expensive.
What is the cheapest day to fly from South Carolina to Des Moines?
Use this chart to determine the cheapest time to fly round-trip from South Carolina to Des Moines. Price data was last updated on March 30, 2025.
Travelers seeking maximum savings on their South Carolina to Des Moines flight should consider departing on Saturday afternoons when fares are most often at their lowest. Tuesday mornings flights should be avoided if possible as fares are typically the most expensive at this time.
How much does it cost to fly round-trip from South Carolina to Des Moines?
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Johnston
Ames
Clive
Ankeny
Boone
West Des Moines
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Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 4, 2026.
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South Carolina and Des Moines flights
Browse other South Carolina and Des Moines flight options. Last updated on April 4, 2026.
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South Carolina to Des Moines flights
Consider these flights traveling from South Carolina to Des Moines.
Top 3 airlines flying from South Carolina to Des Moines
Discover the top 3 airlines that operate flights from South Carolina to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$216 | Average$382 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$216 | Average$374 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$326 | Average$571 | FlexibilityNo cancel fee | On-time69% |