$127+ Cheap flights from South Carolina to Iowa
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/13. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
Dec 3 — Dec 101
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Iowa with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Iowa
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Cheapest flights from South Carolina to IowaExplore the most affordable flight options available from South Carolina to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2026.
Explore the most affordable flight options available from South Carolina to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2026.
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/87:35 pm -
1 stop4h 55m
Thu 12/1011:38 am -
1 stop7h 05m
Deal found 11/1![American Airlines logo]()
$325
This Delta deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/275:40 am -
1 stop6h 04m
Tue 12/15:20 am -
1 stop6h 58m
Deal found 10/31![Delta logo]()
$325
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/251:59 pm -
1 stop5h 08m
Wed 12/26:53 pm -
1 stop3h 58m
Deal found 11/1![Delta logo]()
$327
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:27 pm -
1 stop6h 52m
Sun 12/63:31 pm -
1 stop5h 21m
Deal found 10/29![American Airlines logo]()
$330
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/116:00 am -
1 stop7h 21m
Sun 12/1310:05 am -
1 stop7h 28m
Deal found 10/31![American Airlines logo]()
$339
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/115:00 pm -
1 stop6h 45m
Sun 12/136:05 am -
2 stops8h 27m
Deal found 10/31![United Airlines logo]()
$344
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:04 pm -
1 stop5h 31m
Fri 11/275:30 am -
1 stop6h 55m
Deal found 11/1![Delta logo]()
$354
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/116:59 pm -
1 stop5h 11m
Sun 12/135:05 am -
1 stop4h 02m
Deal found 10/29![Delta logo]()
$359
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/101:59 pm -
1 stop5h 08m
Tue 12/16:53 pm -
1 stop3h 58m
Deal found 11/2![Delta logo]()
$364
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:00 am -
1 stop6h 48m
Tue 11/176:00 am -
1 stop6h 20m
Deal found 10/29![American Airlines logo]()
$369
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:10 pm -
1 stop7h 20m
Tue 11/178:07 am -
1 stop4h 07m
Deal found 11/2![American Airlines logo]()
$379
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:37 pm -
1 stop5h 18m
Tue 11/176:05 am -
2 stops7h 12m
Deal found 11/2![United Airlines logo]()
$384
Best flights from South Carolina to IowaDiscover carefully curated flight deals from South Carolina to Iowa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 3, 2026.
Discover carefully curated flight deals from South Carolina to Iowa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 3, 2026.
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/124:55 pm -
1 stop6h 56m
Mon 2/157:38 am -
1 stop5h 11m
Deal found 11/1![United Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/87:35 pm -
1 stop4h 55m
Thu 12/1011:38 am -
1 stop7h 05m
Deal found 11/1![American Airlines logo]()
$325
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/312:11 pm -
1 stop5h 24m
Tue 2/95:30 am -
1 stop4h 36m
Deal found 11/1![Delta logo]()
$325
This Southwest deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/126:30 am -
1 stop5h 25m
Mon 2/157:30 am -
1 stop3h 45m
Deal found 11/1![Southwest logo]()
$325
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/278:35 pm -
1 stop4h 51m
Fri 12/43:31 pm -
1 stop5h 21m
Deal found 10/30![American Airlines logo]()
$325
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/75:34 pm -
1 stop4h 51m
Fri 12/112:56 pm -
1 stop6h 03m
Deal found 11/2![United Airlines logo]()
$325
This Delta deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/275:40 am -
1 stop6h 04m
Tue 12/15:20 am -
1 stop6h 58m
Deal found 10/31![Delta logo]()
$325
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/37:01 pm -
1 stop4h 37m
Tue 2/95:22 pm -
1 stop4h 44m
Deal found 11/1![Delta logo]()
$325
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:12 pm -
1 stop8h 07m
Wed 12/211:09 am -
1 stop5h 00m
Deal found 10/29![American Airlines logo]()
$327
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/115:00 pm -
1 stop6h 45m
Sun 12/136:05 am -
2 stops8h 27m
Deal found 10/31![United Airlines logo]()
$344
This Southwest deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/72:50 pm -
2 stops8h 15m
Fri 12/116:40 am -
2 stops15h 20m
Deal found 11/2![Southwest logo]()
$397
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/116:00 am -
1 stop7h 21m
Sun 12/1310:05 am -
1 stop7h 28m
Deal found 10/31![American Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/35:10 pm -
1 stop5h 41m
Tue 4/65:45 am -
1 stop4h 33m
Deal found 10/29![Delta logo]()
$339
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:04 pm -
1 stop5h 31m
Fri 11/275:30 am -
1 stop6h 55m
Deal found 11/1![Delta logo]()
$354
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:45 am -
2 stops9h 20m
Sun 12/66:40 am -
2 stops15h 20m
Deal found 10/29![Southwest logo]()
$430
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:00 am -
1 stop6h 48m
Tue 11/176:00 am -
1 stop6h 20m
Deal found 10/29![American Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/710:20 am -
1 stop4h 51m
Sat 4/108:00 am -
1 stop5h 12m
Deal found 10/29![United Airlines logo]()
$415
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/45:38 am -
1 stop6h 23m
Sun 2/710:40 am -
1 stop6h 18m
Deal found 11/1![Delta logo]()
$359
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/311:27 am -
2 stops8h 47m
Sat 2/65:00 am -
2 stops11h 48m
Deal found 10/30![United Airlines logo]()
$421
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/116:59 pm -
1 stop5h 11m
Sun 12/135:05 am -
1 stop4h 02m
Deal found 10/29![Delta logo]()
$359
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/99:46 am -
1 stop5h 44m
Wed 1/136:15 am -
1 stop6h 31m
Deal found 10/29![United Airlines logo]()
$425
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/243:40 pm -
1 stop8h 28m
Sun 12/273:26 pm -
1 stop7h 54m
Deal found 10/30![American Airlines logo]()
$431
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/25:34 pm -
1 stop4h 51m
Sat 12/51:15 pm -
1 stop6h 44m
Deal found 11/2![United Airlines logo]()
$425
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/32:57 pm -
2 stops7h 40m
Mon 2/812:52 pm -
2 stops9h 42m
Deal found 11/1![United Airlines logo]()
$435
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/56:00 am -
2 stops11h 07m
Wed 2/105:30 am -
1 stop7h 23m
Deal found 11/1![Delta logo]()
$456
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/218:28 pm -
1 stop4h 30m
Fri 11/2710:13 am -
1 stop12h 42m
Deal found 11/1![American Airlines logo]()
$503
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/311:27 am -
2 stops12h 03m
Tue 2/96:15 am -
2 stops10h 33m
Deal found 11/1![United Airlines logo]()
$435
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/610:26 am -
2 stops11h 48m
Tue 2/95:22 pm -
1 stop4h 44m
Deal found 11/1![Delta logo]()
$456
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/69:45 am -
1 stop5h 19m
Sat 1/95:00 am -
1 stop5h 08m
Deal found 10/31![United Airlines logo]()
$439
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/195:10 am -
2 stops9h 18m
Mon 11/231:58 pm -
2 stops7h 05m
Deal found 11/2![American Airlines logo]()
$535
Last-minute flights from South Carolina to IowaDiscover last-minute flight deals from South Carolina to Iowa. Data last updated November 3, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Iowa. Data last updated November 3, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/101:59 pm -
1 stop5h 08m
Tue 12/16:53 pm -
1 stop3h 58m
Deal found 11/2![Delta logo]()
$364
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:10 pm -
1 stop7h 20m
Tue 11/178:07 am -
1 stop4h 07m
Deal found 11/2![American Airlines logo]()
$379
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:37 pm -
1 stop5h 18m
Tue 11/176:05 am -
2 stops7h 12m
Deal found 11/2![United Airlines logo]()
$384
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:58 pm -
1 stop5h 11m
Sat 11/145:15 am -
1 stop3h 52m
Deal found 11/2![Delta logo]()
$397
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:00 am -
1 stop6h 48m
Tue 11/176:00 am -
1 stop6h 20m
Deal found 10/29![American Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:51 pm -
1 stop5h 18m
Sun 11/155:15 am -
1 stop3h 52m
Deal found 10/29![Delta logo]()
$389
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:04 pm -
1 stop5h 31m
Fri 11/275:30 am -
1 stop6h 55m
Deal found 11/1![Delta logo]()
$354
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/251:59 pm -
1 stop5h 08m
Wed 12/26:53 pm -
1 stop3h 58m
Deal found 11/1![Delta logo]()
$327
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:27 pm -
1 stop6h 52m
Sun 12/63:31 pm -
1 stop5h 21m
Deal found 10/29![American Airlines logo]()
$330
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:05 pm -
2 stops45h 40m
Sun 12/69:07 am -
1 stop22h 06m
Deal found 10/29![Multiple Airlines logo]()
$392
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/258:28 pm -
1 stop4h 58m
Wed 12/22:05 pm -
2 stops7h 55m
Deal found 10/29![American Airlines logo]()
$395
This Delta deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/275:40 am -
1 stop6h 04m
Tue 12/15:20 am -
1 stop6h 58m
Deal found 10/31![Delta logo]()
$325
One-way flights from South Carolina to IowaSearch for one-way flight options from South Carolina to Iowa. Find affordable one-way fares based on user searches. Data last updated November 3, 2026.
Search for one-way flight options from South Carolina to Iowa. Find affordable one-way fares based on user searches. Data last updated November 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/133:14 pm -
1 stop8h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![Multiple Airlines logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/710:15 pm -
1 stop13h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![Multiple Airlines logo]()
$130
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/51:05 pm -
1 stop5h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Delta logo]()
$163
This Southwest deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/31:35 pm -
2 stops8h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Southwest logo]()
$168
This Southwest deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/16:20 am -
2 stops7h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Southwest logo]()
$202
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/53:23 pm -
2 stops8h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![United Airlines logo]()
$218
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/76:00 am -
1 stop5h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Delta logo]()
$219
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/203:14 pm -
1 stop7h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Multiple Airlines logo]()
$228
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:45 am -
2 stops40h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![Multiple Airlines logo]()
$239
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/76:25 pm -
1 stop6h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![American Airlines logo]()
$249
This Southwest deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/216:25 am -
1 stop4h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Southwest logo]()
$259
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/124:15 pm -
1 stop8h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![United Airlines logo]()
$269
Find flight deals from South Carolina to Iowa
Keep the following information in mind while searching for South Carolina to Iowa flight deals. Data was last updated November 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $325 (American Airlines) |
One-way from | $127 (Kiwi.com) |
Popular in | July |
Cheapest in | February |
Average price | $536 |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 3, 2026.
Use the filters below to find and compare flights from South Carolina to Iowa that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Fri 11/13
3:14 pm-10:15 pm
1 stop8h 01m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$127
CharlestonCedar Rapids
CHS Charleston - CID Cedar Rapids
CHSCID
Charleston
Thu 1/7
10:15 pm-10:25 am
1 stop13h 10m
Cedar Rapids
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$130
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Tue 1/5
1:05 pm-5:19 pm
1 stop5h 14m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$163
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Mon 3/1
5:30 am-10:18 am
1 stop5h 48m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$163
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Mon 3/1
6:20 am-1:10 pm
2 stops7h 50m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$202
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Tue 1/5
3:23 pm-11:14 pm
2 stops8h 51m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$218
Myrtle BeachDes Moines
MYR Myrtle Beach Intl - DSM Des Moines
MYRDSM
Myrtle Beach Intl
Sun 3/7
6:00 am-10:18 am
1 stop5h 18m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$219
Myrtle BeachDes Moines
MYR Myrtle Beach Intl - DSM Des Moines
MYRDSM
Myrtle Beach Intl
Sun 3/7
6:25 pm-11:58 pm
1 stop6h 33m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$249
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Sun 3/21
6:25 am-9:50 am
1 stop4h 25m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$259
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Thu 11/12
7:00 am-8:21 am
2 stops26h 21m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$266
Showing 1-10 of 56 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Iowa
Have a flexible travel schedule? Discover the best time to fly to Iowa from South Carolina with our price prediction graph.
CHS-DSM
MYR-DSM
CHS-CID
CAE-DSM
CHS-FOD
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Iowa
USSC-USIA
CHS-DSM
MYR-DSM
CHS-CID
CAE-DSM
What is the cheapest month to book a flight from South Carolina to Iowa?
Currently, February is the cheapest month in which you can book a flight from South Carolina to Iowa (average of $340). Flying from South Carolina to Iowa in March is currently the most expensive (average of $695). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Iowa
Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated November 3, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from South Carolina to Iowa have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Boarding
8.1
Overall
7.8
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Comfort
7.8
Boarding
8.1
Overall
7.8
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Comfort
7.8
Boarding
8.1
Overall
7.8
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Comfort
7.8
Boarding
8.1
Overall
7.8
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for South Carolina to Iowa
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Iowa by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Iowa by cabin class
Find flights from South Carolina to Iowa, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Iowa flights
Browse other South Carolina and Iowa flight options. Last updated on November 3, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Iowa
Find the right flight back to South Carolina after your stay in Iowa
South Carolina to Iowa flights
Consider these flights traveling from South Carolina to Iowa.
Top 3 airlines flying from South Carolina to Iowa
Discover the top 3 airlines that operate flights from South Carolina to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$233 | Average$406 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$280 | Average$390 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$294 | Average$411 | FlexibilityNo cancel fee | On-timeN/A |