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$78+ Cheap flights from South Carolina to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/28. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
May 29 — Jun 51
Fri 5/29
Fri 6/5
1 adult, Economy
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Cheap flight deals from South Carolina to Iowa

Cheapest flights from South Carolina to Iowa
Explore the most affordable flight options available from South Carolina to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2026.

This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/289:07 pm
CLT
-
CID
1 stop21h 14m
Multiple Airlines
Mon 6/16:11 pm
CID
-
CLT
1 stop16h 54m
Multiple Airlines
Deal found 4/28$164
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/149:07 pm
CLT
-
CID
1 stop21h 48m
Multiple Airlines
Mon 5/186:45 pm
CID
-
CLT
1 stop16h 20m
Multiple Airlines
Deal found 4/29$167
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/79:07 pm
CLT
-
CID
1 stop21h 48m
Multiple Airlines
Mon 5/116:45 pm
CID
-
CLT
1 stop16h 20m
Multiple Airlines
Deal found 4/28$182
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:56 am
CLT
-
CID
1 stop9h 59m
Multiple Airlines
Fri 5/86:45 pm
CID
-
CLT
1 stop15h 49m
Multiple Airlines
Deal found 4/24$209
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:00 am
CLT
-
CID
1 stop12h 21m
Multiple Airlines
Mon 6/16:11 pm
CID
-
CLT
1 stop16h 54m
Multiple Airlines
Deal found 4/28$213
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/133:16 pm
CLT
-
DSM
1 stop24h 59m
Multiple Airlines
Sun 5/177:45 am
DSM
-
CLT
1 stop27h 20m
Multiple Airlines
Deal found 4/26$214
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:58 pm
CLT
-
CID
1 stop14h 31m
Multiple Airlines
Mon 6/16:11 pm
CID
-
CLT
1 stop16h 54m
Multiple Airlines
Deal found 4/28$221
This Frontier deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:14 pm
CLT
-
DSM
1 stop19h 17m
Frontier
Mon 6/12:16 pm
DSM
-
CLT
1 stop27h 02m
Frontier
Deal found 4/29$225
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/273:16 pm
CLT
-
CID
2 stops18h 11m
Multiple Airlines
Mon 6/16:11 pm
CID
-
CLT
1 stop16h 54m
Multiple Airlines
Deal found 4/28$226
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:58 pm
CLT
-
CID
1 stop14h 31m
Multiple Airlines
Fri 5/296:11 pm
CID
-
CLT
1 stop16h 23m
Multiple Airlines
Deal found 4/28$231
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:57 pm
CLT
-
CID
1 stop12h 58m
Multiple Airlines
Fri 5/296:11 pm
CID
-
CLT
1 stop16h 23m
Multiple Airlines
Deal found 4/28$232
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:00 am
CLT
-
DSM
1 stop18h 27m
Multiple Airlines
Mon 6/156:44 pm
DSM
-
CLT
1 stop16h 30m
Multiple Airlines
Deal found 4/25$240

Find flight deals from South Carolina to Iowa

Keep the following information in mind while searching for South Carolina to Iowa flight deals. Data was last updated April 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$164
(Kiwi.com)

One-way from

$78
(Kiwi.com)

Popular in

December

Cheapest in

July

Average price

$340
Provider with most accurate pricing for Myrtle Beach Intl-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Des Moines flights.
Search Deals
From South Carolina to Iowa
Search Deals
One-way flight from South Carolina to Iowa
Search Deals
Highest demand for flights based on searches. 28% potential increase in price ($168 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($25 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2026.
Use the filters below to find and compare flights from South Carolina to Iowa that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ColumbiaOmaha

CAE - OMA

CAEOMA

Columbia Metropolitan

Wed 6/10

5:35 am-9:43 am

1 stop5h 08m

Omaha Eppley Airfield

Wed 8/12

7:00 am-2:12 pm

1 stop6h 12m

$291

ColumbiaOmaha

CAE - OMA

CAEOMA

Columbia Metropolitan

Wed 6/10

4:05 pm-11:30 pm

1 stop8h 25m

Omaha Eppley Airfield

Thu 8/13

5:35 am-11:17 am

1 stop4h 42m

$315

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 6/17

6:00 am-10:43 am

1 stop5h 43m

Des Moines

Tue 6/23

6:39 pm-11:59 pm

1 stop4h 20m

$335

ColumbiaOmaha

CAE - OMA

CAEOMA

Columbia Metropolitan

Wed 5/20

2:37 pm-11:31 pm

2 stops9h 54m

Omaha Eppley Airfield

Wed 7/22

6:00 am-2:16 pm

2 stops7h 16m

$349

CharlotteMoline

CLT - MLI

CLTMLI

Charlotte Douglas

Wed 5/6

7:30 am-8:34 am

2 stops26h 04m

Moline Quad-City

Wed 5/20

5:52 pm-4:43 pm

1 stop21h 51m

$354

CharlotteMoline

CLT - MLI

CLTMLI

Charlotte Douglas

Sat 7/18

6:00 am-1:56 pm

2 stops8h 56m

Moline Quad-City

Sat 7/25

2:31 pm-9:29 pm

1 stop5h 58m

$358

AugustaOmaha

AGS - OMA

AGSOMA

Augusta Bush Field

Sat 6/27

6:19 pm-11:50 pm

1 stop6h 31m

Omaha Eppley Airfield

Sat 7/11

12:00 pm-8:18 pm

1 stop7h 18m

$363

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Wed 5/20

5:45 pm-9:23 pm

1 stop4h 38m

Des Moines

Sun 5/24

11:18 am-5:00 pm

1 stop4h 42m

$371

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 9/30

11:10 am-4:49 pm

1 stop6h 39m

Des Moines

Mon 10/5

6:30 pm-11:39 pm

1 stop4h 09m

$371

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 9/9

11:10 am-4:49 pm

1 stop6h 39m

Des Moines

Mon 9/21

6:30 pm-11:39 pm

1 stop4h 09m

$371

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/29

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from South Carolina to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Iowa

What is the cheapest month to book a flight from South Carolina to Iowa?

Currently, September is the cheapest month in which you can book a flight from South Carolina to Iowa (average of $140). Flying from South Carolina to Iowa in April is currently the most expensive (average of $273). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from South Carolina to Iowa?

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated April 29, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from South Carolina to Iowa have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,466 reviews

Crew

8.5

Entertainment

7.8

Comfort

7.9

Food

7.2

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,466 reviews
Delta
7.9
Good
8,466 reviews

Crew

8.5

Entertainment

7.8

Comfort

7.9

Food

7.2

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,680 reviews
Delta
7.9
Good
8,466 reviews

Crew

8.5

Entertainment

7.8

Comfort

7.9

Food

7.2

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,678 reviews
Delta
7.9
Good
8,466 reviews

Crew

8.5

Entertainment

7.8

Comfort

7.9

Food

7.2

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to Iowa?

    Airlines like Delta, United Airlines, and Southwest fly from South Carolina to Iowa in about 5h 08m. The time it takes to get you to your destination can typically vary by up to 10h 27m. South Carolina and Iowa are separated by a distance of 952 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from South Carolina to Iowa one-way?

    To fly one-way, consider booking your trip with United Airlines, which is currently one of the cheapest options available, starting at $191. American Airlines flights start at $217 while deals on Delta start at $396 one-way.

  • Can I find deals for flights from South Carolina to Iowa that include hotel bookings?

    Yes. In addition to deals on South Carolina to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Iowa.

  • Can I find deals for business class flights from South Carolina to Iowa?

    Yes. Cheapflights offers flight deals from South Carolina to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Iowa?

    Currently, September is the cheapest month in which you can book a flight from South Carolina to Iowa (average of $140). Flying from South Carolina to Iowa in April is currently the most expensive (average of $273). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Iowa

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Iowa

Discover the top 3 airlines that operate flights from South Carolina to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$216Average$380FlexibilityNo cancel feeOn-time71%
DeltaCheapest$216Average$368FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$326Average$571FlexibilityNo cancel feeOn-time69%

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