$115+ Cheap flights from South Carolina to Iowa
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/14. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
Oct 20 — Oct 271
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Iowa with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Iowa
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Cheapest flights from South Carolina to IowaExplore the most affordable flight options available from South Carolina to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 20, 2026.
Explore the most affordable flight options available from South Carolina to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 20, 2026.
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/258:55 am -
Nonstop2h 53m
Tue 12/111:33 am -
Nonstop2h 42m
Deal found 9/16![American Airlines logo]()
$229
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/85:30 am -
1 stop5h 39m
Tue 12/1511:09 am -
1 stop6h 02m
Deal found 9/16![Delta logo]()
$249
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/88:05 am -
2 stops10h 15m
Tue 12/154:00 pm -
1 stop4h 20m
Deal found 9/15![Southwest logo]()
$254
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2711:15 am -
1 stop6h 33m
Sat 10/318:00 am -
1 stop4h 18m
Deal found 9/16![Delta logo]()
$255
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/86:00 am -
2 stops7h 17m
Tue 12/156:00 am -
2 stops7h 16m
Deal found 9/15![United Airlines logo]()
$259
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/275:37 pm -
1 stop4h 38m
Sat 10/318:07 am -
2 stops9h 11m
Deal found 9/15![American Airlines logo]()
$260
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1510:47 pm -
Nonstop2h 51m
Mon 10/196:45 am -
Nonstop2h 36m
Deal found 9/16![American Airlines logo]()
$263
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/126:00 am -
1 stop4h 49m
Thu 12/175:38 pm -
1 stop5h 18m
Deal found 9/15![Delta logo]()
$266
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:05 am -
1 stop7h 04m
Sat 10/315:39 am -
1 stop6h 00m
Deal found 9/15![Delta logo]()
$269
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:15 am -
1 stop4h 30m
Sat 10/1712:55 pm -
1 stop6h 45m
Deal found 9/17![Southwest logo]()
$273
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/281:25 pm -
2 stops9h 35m
Sat 10/315:20 am -
2 stops10h 05m
Deal found 9/15![Southwest logo]()
$281
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/116:30 am -
1 stop4h 39m
Tue 12/1510:29 am -
1 stop4h 43m
Deal found 9/15![Delta logo]()
$282
Best flights from South Carolina to IowaDiscover carefully curated flight deals from South Carolina to Iowa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 20, 2026.
Discover carefully curated flight deals from South Carolina to Iowa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 20, 2026.
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/85:30 am -
1 stop5h 39m
Tue 12/1511:09 am -
1 stop6h 02m
Deal found 9/16![Delta logo]()
$249
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:45 am -
1 stop4h 40m
Mon 10/193:13 pm -
1 stop5h 02m
Deal found 9/16![United Airlines logo]()
$283
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:30 am -
2 stops8h 10m
Mon 10/265:10 am -
1 stop10h 20m
Deal found 9/16![Southwest logo]()
$299
This American Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:16 am -
1 stop4h 35m
Sat 10/106:00 am -
2 stops9h 01m
Deal found 9/19![American Airlines logo]()
$359
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/19:40 pm -
1 stop22h 33m
Mon 10/56:20 pm -
1 stop13h 15m
Deal found 9/17![Multiple Airlines logo]()
$515
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:05 am -
1 stop7h 04m
Sat 10/315:39 am -
1 stop6h 00m
Deal found 9/15![Delta logo]()
$269
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2810:26 am -
2 stops8h 01m
Sat 10/318:00 am -
1 stop4h 21m
Deal found 9/15![United Airlines logo]()
$293
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:40 am -
2 stops8h 35m
Tue 11/173:30 pm -
1 stop4h 55m
Deal found 9/16![Southwest logo]()
$302
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:05 am -
1 stop5h 37m
Mon 10/266:54 pm -
1 stop4h 03m
Deal found 9/16![Delta logo]()
$288
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:50 pm -
1 stop5h 29m
Mon 10/191:03 pm -
1 stop7h 30m
Deal found 9/15![United Airlines logo]()
$306
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/31:30 pm -
2 stops10h 05m
Fri 11/611:35 am -
1 stop7h 40m
Deal found 9/17![Southwest logo]()
$313
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:45 pm -
1 stop5h 20m
Mon 10/54:19 pm -
1 stop6h 38m
Deal found 9/18![American Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/253:38 pm -
1 stop5h 00m
Wed 12/305:40 am -
1 stop8h 10m
Deal found 9/15![United Airlines logo]()
$316
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/911:26 am -
2 stops12h 44m
Sun 12/135:05 am -
1 stop4h 02m
Deal found 9/17![Delta logo]()
$320
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:45 pm -
1 stop5h 20m
Wed 10/75:03 pm -
1 stop5h 56m
Deal found 9/18![American Airlines logo]()
$369
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:15 am -
1 stop4h 30m
Sat 10/177:30 am -
2 stops11h 15m
Deal found 9/17![Southwest logo]()
$351
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:31 pm -
1 stop5h 02m
Mon 10/126:54 pm -
1 stop4h 03m
Deal found 9/17![Delta logo]()
$325
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/810:55 am -
1 stop6h 20m
Tue 12/157:41 am -
2 stops10h 20m
Deal found 9/16![United Airlines logo]()
$334
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:53 am -
1 stop4h 55m
Sun 11/2211:28 am -
1 stop5h 09m
Deal found 9/15![American Airlines logo]()
$380
This Southwest deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:40 am -
1 stop4h 30m
Mon 10/194:30 pm -
1 stop4h 20m
Deal found 9/19![Southwest logo]()
$377
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:05 am -
1 stop5h 37m
Tue 10/273:03 pm -
1 stop5h 14m
Deal found 9/18![Delta logo]()
$343
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:30 am -
1 stop4h 42m
Sat 10/1010:49 am -
2 stops12h 10m
Deal found 9/16![United Airlines logo]()
$344
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/151:35 pm -
2 stops11h 00m
Mon 10/194:00 pm -
1 stop4h 50m
Deal found 9/15![Southwest logo]()
$379
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/78:10 am -
1 stop5h 09m
Mon 11/911:30 am -
1 stop8h 59m
Deal found 9/17![United Airlines logo]()
$346
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/79:34 am -
1 stop8h 22m
Fri 12/115:46 pm -
1 stop18h 04m
Deal found 9/15![Multiple Airlines logo]()
$562
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:00 am -
1 stop6h 10m
Sun 11/15:25 am -
1 stop7h 13m
Deal found 9/17![Delta logo]()
$363
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:33 pm -
1 stop6h 34m
Mon 12/75:03 pm -
1 stop6h 06m
Deal found 9/17![American Airlines logo]()
$457
This Southwest deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/244:10 pm -
1 stop5h 40m
Sat 10/315:20 am -
1 stop10h 05m
Deal found 9/19![Southwest logo]()
$382
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/94:23 pm -
1 stop6h 00m
Mon 10/121:24 pm -
1 stop7h 24m
Deal found 9/17![United Airlines logo]()
$360
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/206:34 am -
1 stop4h 31m
Mon 11/235:30 am -
1 stop6h 22m
Deal found 9/15![Delta logo]()
$373
Last-minute flights from South Carolina to IowaDiscover last-minute flight deals from South Carolina to Iowa. Data last updated September 20, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Iowa. Data last updated September 20, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:00 am -
1 stop6h 10m
Mon 10/125:55 pm -
1 stop4h 55m
Deal found 9/16![Delta logo]()
$266
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:15 am -
1 stop4h 30m
Sat 10/1712:55 pm -
1 stop6h 45m
Deal found 9/17![Southwest logo]()
$273
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1410:55 am -
Nonstop2h 46m
Wed 10/213:00 pm -
Nonstop2h 32m
Deal found 9/15![American Airlines logo]()
$229
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/147:04 am -
1 stop5h 56m
Wed 10/215:25 am -
1 stop4h 41m
Deal found 9/15![Delta logo]()
$249
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1410:25 am -
2 stops8h 06m
Wed 10/211:55 pm -
1 stop6h 36m
Deal found 9/15![United Airlines logo]()
$287
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1510:47 pm -
Nonstop2h 51m
Mon 10/196:45 am -
Nonstop2h 36m
Deal found 9/16![American Airlines logo]()
$263
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:45 am -
1 stop4h 40m
Mon 10/193:13 pm -
1 stop5h 02m
Deal found 9/16![United Airlines logo]()
$283
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:05 am -
1 stop5h 37m
Mon 10/266:54 pm -
1 stop4h 03m
Deal found 9/16![Delta logo]()
$288
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2711:15 am -
1 stop6h 33m
Sat 10/318:00 am -
1 stop4h 18m
Deal found 9/16![Delta logo]()
$255
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/275:37 pm -
1 stop4h 38m
Sat 10/318:07 am -
2 stops9h 11m
Deal found 9/15![American Airlines logo]()
$260
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:05 am -
1 stop7h 04m
Sat 10/315:39 am -
1 stop6h 00m
Deal found 9/15![Delta logo]()
$269
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/281:25 pm -
2 stops9h 35m
Sat 10/315:20 am -
2 stops10h 05m
Deal found 9/15![Southwest logo]()
$281
One-way flights from South Carolina to IowaSearch for one-way flight options from South Carolina to Iowa. Find affordable one-way fares based on user searches. Data last updated September 20, 2026.
Search for one-way flight options from South Carolina to Iowa. Find affordable one-way fares based on user searches. Data last updated September 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1412:23 pm -
1 stop29h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Multiple Airlines logo]()
$115
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/147:25 am -
1 stop5h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Southwest logo]()
$125
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:15 am -
1 stop5h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Southwest logo]()
$128
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/156:40 am -
2 stops8h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Southwest logo]()
$130
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/178:05 am -
2 stops10h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Southwest logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/303:42 pm -
1 stop17h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Multiple Airlines logo]()
$133
This CheapOair deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/164:47 pm -
1 stop28h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Frontier logo]()
$137
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2112:05 pm -
2 stops20h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/19![Multiple Airlines logo]()
$138
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/510:13 pm -
1 stop13h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Multiple Airlines logo]()
$143
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:30 am -
1 stop5h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Southwest logo]()
$145
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1411:40 am -
2 stops11h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Southwest logo]()
$146
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/149:32 am -
2 stops23h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Multiple Airlines logo]()
$146
Find flight deals from South Carolina to Iowa
Keep the following information in mind while searching for South Carolina to Iowa flight deals. Data was last updated September 20, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $229 (American Airlines) |
One-way from | $115 (Kiwi.com) |
Popular in | July |
Cheapest in | February |
Average price | $406 |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 20, 2026.
Use the filters below to find and compare flights from South Carolina to Iowa that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
SavannahDes Moines
SAV Savannah/Hilton Head - DSM Des Moines
SAVDSM
Savannah/Hilton Head
Wed 10/14
12:23 pm-4:52 pm
1 stop29h 29m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$115
CharlotteOmaha
CLT Charlotte Douglas - OMA Omaha Eppley Airfield
CLTOMA
Charlotte Douglas
Tue 11/17
6:50 pm-10:40 pm
1 stop4h 50m
Omaha Eppley Airfield
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$125
CharlotteOmaha
CLT Charlotte Douglas - OMA Omaha Eppley Airfield
CLTOMA
Charlotte Douglas
Wed 10/14
7:25 am-11:45 am
1 stop5h 20m
Omaha Eppley Airfield
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$125
CharlotteOmaha
CLT Charlotte Douglas - OMA Omaha Eppley Airfield
CLTOMA
Charlotte Douglas
Tue 12/15
7:40 am-11:35 am
1 stop4h 55m
Omaha Eppley Airfield
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$125
CharlestonOmaha
CHS Charleston - OMA Omaha Eppley Airfield
CHSOMA
Charleston
Wed 10/28
7:15 am-11:45 am
1 stop5h 30m
Omaha Eppley Airfield
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$128
CharlestonOmaha
CHS Charleston - OMA Omaha Eppley Airfield
CHSOMA
Charleston
Thu 11/5
5:30 am-10:20 am
1 stop5h 50m
Omaha Eppley Airfield
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$145
SavannahDes Moines
SAV Savannah/Hilton Head - DSM Des Moines
SAVDSM
Savannah/Hilton Head
Wed 10/14
11:40 am-10:00 pm
2 stops11h 20m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$146
CharlotteDes Moines
CLT Charlotte Douglas - DSM Des Moines
CLTDSM
Charlotte Douglas
Tue 12/15
6:40 am-2:15 pm
2 stops8h 35m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$154
CharlestonOmaha
CHS Charleston - OMA Omaha Eppley Airfield
CHSOMA
Charleston
Fri 10/16
4:58 pm-11:19 pm
1 stop7h 21m
Omaha Eppley Airfield
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$162
CharlestonOmaha
CHS Charleston - OMA Omaha Eppley Airfield
CHSOMA
Charleston
Fri 10/16
1:25 pm-11:35 pm
2 stops11h 10m
Omaha Eppley Airfield
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$167
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Iowa
Have a flexible travel schedule? Discover the best time to fly to Iowa from South Carolina with our price prediction graph.
CLT-OMA
CHS-OMA
GSP-DSM
SAV-DSM
CLT-CID
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Iowa
USSC-USIA
CLT-OMA
CHS-OMA
GSP-DSM
SAV-DSM
What is the cheapest month to book a flight from South Carolina to Iowa?
Currently, February is the cheapest month in which you can book a flight from South Carolina to Iowa (average of $340). Flying from South Carolina to Iowa in March is currently the most expensive (average of $695). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from South Carolina to Iowa?
Airfare is below average for this route at the moment.
South Carolina to Iowa flights typically cost between $382 and $458 in October.The cheapest round-trip price found within the last 5 days was $269 on Delta (Oct 10-Oct 17).
Reviews of airlines servicing Iowa
Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated September 20, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from South Carolina to Iowa have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
7.8
Overall
7.8
Entertainment
7.8
Food
7.2
Crew
8.5
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Boarding
8.1
Comfort
7.8
Overall
7.8
Entertainment
7.8
Food
7.2
Crew
8.5
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Boarding
8.1
Comfort
7.8
Overall
7.8
Entertainment
7.8
Food
7.2
Crew
8.5
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Boarding
8.1
Comfort
7.8
Overall
7.8
Entertainment
7.8
Food
7.2
Crew
8.5
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for South Carolina to Iowa
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Iowa by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Iowa by cabin class
Find flights from South Carolina to Iowa, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Iowa flights
Browse other South Carolina and Iowa flight options. Last updated on September 20, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Iowa
Find the right flight back to South Carolina after your stay in Iowa
South Carolina to Iowa flights
Consider these flights traveling from South Carolina to Iowa.
Top 3 airlines flying from South Carolina to Iowa
Discover the top 3 airlines that operate flights from South Carolina to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$233 | Average$410 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$280 | Average$390 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$286 | Average$420 | FlexibilityNo cancel fee | On-timeN/A |