$122+ Cheap flights from South Carolina to Iowa
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/29. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
Aug 29 — Sep 51
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Iowa with Cheapflights
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Iowa
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Cheapest flights from South Carolina to IowaExplore the most affordable flight options available from South Carolina to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2026.
Explore the most affordable flight options available from South Carolina to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2026.
This CheapOair deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/195:21 pm
CLT
- OMA
1 stop21h 12m
Frontier
Fri 8/212:18 pm
OMA
- CLT
1 stop25h 08m
Frontier
Deal found 7/29![Frontier logo]()
$249
This CheapOair deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/3110:04 pm
CLT
- OMA
1 stop22h 11m
Frontier
Sun 8/28:00 pm
OMA
- CLT
1 stop24h 19m
Frontier
Deal found 7/27![Frontier logo]()
$266
This CheapOair deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/710:04 pm
CLT
- OMA
1 stop22h 11m
Frontier
Tue 8/118:15 pm
OMA
- CLT
1 stop24h 04m
Frontier
Deal found 7/26![Frontier logo]()
$267
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:59 pm
GSP
- DSM
1 stop27h 09m
Multiple Airlines
Mon 9/1410:24 am
DSM
- GSP
1 stop6h 46m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$297
This CheapOair deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2910:04 pm
CLT
- OMA
1 stop22h 11m
Frontier
Sun 8/28:00 pm
OMA
- CLT
1 stop24h 19m
Frontier
Deal found 7/26![Frontier logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/269:52 pm
CLT
- DSM
2 stops23h 02m
Multiple Airlines
Sun 8/301:55 pm
DSM
- CLT
1 stop17h 56m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/69:34 am
CLT
- OMA
1 stop27h 16m
Multiple Airlines
Mon 12/1412:40 pm
OMA
- CLT
1 stop23h 10m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/299:52 pm
CLT
- DSM
2 stops23h 02m
Multiple Airlines
Sun 9/61:58 pm
DSM
- CLT
1 stop17h 53m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$315
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:25 pm
MYR
- DSM
1 stop14h 29m
Multiple Airlines
Mon 10/511:00 am
DSM
- MYR
1 stop22h 05m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$315
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:10 am
CLT
- DSM
1 stop4h 15m
Southwest
Mon 8/315:40 am
DSM
- CLT
1 stop4h 30m
Southwest
Deal found 7/26![Southwest logo]()
$321
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/268:05 am
CLT
- OMA
1 stop4h 35m
Southwest
Wed 9/23:05 pm
OMA
- CLT
1 stop5h 05m
Southwest
Deal found 7/29![Southwest logo]()
$321
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/29:52 pm
CLT
- DSM
2 stops23h 05m
Multiple Airlines
Sun 9/61:58 pm
DSM
- CLT
1 stop17h 53m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$323
Best flights from South Carolina to IowaDiscover carefully curated flight deals from South Carolina to Iowa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 30, 2026.
Discover carefully curated flight deals from South Carolina to Iowa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 30, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:59 pm
GSP
- DSM
1 stop27h 09m
Multiple Airlines
Mon 9/1410:24 am
DSM
- GSP
1 stop6h 46m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$297
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/308:05 am
CLT
- DSM
1 stop4h 45m
Southwest
Tue 10/65:35 am
DSM
- CLT
1 stop4h 05m
Southwest
Deal found 7/25![Southwest logo]()
$321
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:30 am
MYR
- DSM
1 stop6h 34m
American Airlines
Mon 10/511:22 am
DSM
- MYR
1 stop7h 05m
American Airlines
Deal found 7/28![American Airlines logo]()
$325
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:30 am
GSP
- OMA
1 stop4h 52m
United Airlines
Sat 9/57:25 am
OMA
- GSP
2 stops10h 40m
United Airlines
Deal found 7/26![United Airlines logo]()
$330
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2811:25 am
GSP
- MLI
1 stop6h 00m
Delta
Fri 9/411:08 am
MLI
- GSP
1 stop4h 07m
Delta
Deal found 7/29![Delta logo]()
$339
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/28:05 am
CLT
- DSM
1 stop4h 45m
Southwest
Wed 9/96:10 am
DSM
- CLT
1 stop4h 45m
Southwest
Deal found 7/29![Southwest logo]()
$321
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/85:40 am
GSP
- MLI
1 stop5h 42m
Delta
Tue 10/136:00 am
MLI
- GSP
1 stop6h 05m
Delta
Deal found 7/30![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/145:19 pm
GSP
- MLI
1 stop4h 54m
American Airlines
Sat 8/226:00 am
MLI
- GSP
2 stops7h 47m
American Airlines
Deal found 7/29![American Airlines logo]()
$339
This Kiwi.com deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/103:52 pm
GSP
- DSM
1 stop18h 17m
Multiple Airlines
Sun 9/131:58 pm
DSM
- GSP
2 stops28h 07m
Multiple Airlines
Deal found 7/25![Multiple Airlines logo]()
$348
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/104:19 pm
GSP
- DSM
1 stop8h 14m
United Airlines
Mon 9/146:24 am
DSM
- GSP
2 stops6h 56m
United Airlines
Deal found 7/29![United Airlines logo]()
$350
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/238:05 am
CLT
- DSM
1 stop4h 45m
Southwest
Tue 9/296:10 am
DSM
- CLT
1 stop4h 45m
Southwest
Deal found 7/25![Southwest logo]()
$321
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1611:04 am
GSP
- OMA
1 stop7h 16m
Delta
Mon 9/215:30 pm
OMA
- GSP
1 stop4h 25m
Delta
Deal found 7/28![Delta logo]()
$343
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/175:31 pm
CHS
- OMA
1 stop4h 45m
American Airlines
Sat 9/1910:26 am
OMA
- CHS
2 stops9h 40m
American Airlines
Deal found 7/27![American Airlines logo]()
$344
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:25 pm
CLT
- OMA
1 stop5h 05m
Southwest
Thu 10/294:00 pm
OMA
- CLT
1 stop4h 45m
Southwest
Deal found 7/27![Southwest logo]()
$321
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/144:23 pm
CLT
- OMA
1 stop8h 19m
United Airlines
Wed 9/301:55 pm
OMA
- CLT
1 stop6h 36m
United Airlines
Deal found 7/27![United Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:30 am
CLT
- OMA
1 stop5h 37m
Delta
Tue 12/15:39 pm
OMA
- CLT
1 stop5h 15m
Delta
Deal found 7/28![Delta logo]()
$343
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:34 pm
GSP
- MLI
1 stop6h 34m
American Airlines
Sat 8/154:05 pm
MLI
- GSP
1 stop4h 45m
American Airlines
Deal found 7/27![American Airlines logo]()
$349
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:55 am
CLT
- DSM
1 stop4h 35m
Southwest
Sun 9/66:05 am
DSM
- CLT
1 stop10h 10m
Southwest
Deal found 7/29![Southwest logo]()
$331
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2810:25 am
GSP
- MLI
2 stops10h 06m
United Airlines
Fri 9/410:30 am
MLI
- GSP
1 stop5h 32m
United Airlines
Deal found 7/29![United Airlines logo]()
$380
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/271:10 pm
CLT
- OMA
2 stops9h 55m
Southwest
Fri 10/305:05 am
OMA
- CLT
1 stop4h 30m
Southwest
Deal found 7/27![Southwest logo]()
$331
This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:30 am
CLT
- OMA
1 stop5h 12m
Delta
Sat 8/157:49 am
OMA
- CLT
1 stop6h 59m
Delta
Deal found 7/26![Delta logo]()
$369
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:01 pm
MYR
- DSM
1 stop7h 11m
American Airlines
Sun 10/46:00 am
DSM
- MYR
1 stop7h 37m
American Airlines
Deal found 7/26![American Airlines logo]()
$371
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/293:30 pm
CLT
- MLI
1 stop5h 01m
United Airlines
Tue 9/11:15 pm
MLI
- CLT
2 stops9h 41m
United Airlines
Deal found 7/30![United Airlines logo]()
$388
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/261:30 pm
CLT
- OMA
2 stops9h 15m
Southwest
Wed 9/27:30 am
OMA
- CLT
2 stops10h 30m
Southwest
Deal found 7/28![Southwest logo]()
$331
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:05 pm
CHS
- OMA
1 stop6h 31m
American Airlines
Mon 10/2611:39 am
OMA
- CHS
1 stop5h 36m
American Airlines
Deal found 7/29![American Airlines logo]()
$375
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/155:30 am
CHS
- OMA
1 stop5h 07m
Delta
Sun 10/188:15 am
OMA
- CHS
1 stop5h 08m
Delta
Deal found 7/27![Delta logo]()
$388
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/279:07 am
SAV
- DSM
1 stop6h 12m
United Airlines
Sat 10/315:30 am
DSM
- SAV
1 stop8h 40m
United Airlines
Deal found 7/27![United Airlines logo]()
$405
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/204:10 pm
SAV
- DSM
2 stops7h 00m
Southwest
Mon 8/245:40 am
DSM
- SAV
2 stops10h 15m
Southwest
Deal found 7/28![Southwest logo]()
$335
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/187:40 pm
CLT
- OMA
Nonstop2h 36m
American Airlines
Sun 9/205:34 pm
OMA
- CLT
Nonstop2h 35m
American Airlines
Deal found 7/25![American Airlines logo]()
$375
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/314:50 pm
SAV
- DSM
1 stop5h 55m
United Airlines
Tue 11/311:23 am
DSM
- SAV
1 stop5h 17m
United Airlines
Deal found 7/29![United Airlines logo]()
$405
Last-minute flights from South Carolina to IowaDiscover last-minute flight deals from South Carolina to Iowa. Data last updated July 30, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Iowa. Data last updated July 30, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/3110:04 pm
CLT
- OMA
1 stop22h 11m
Frontier
Sun 8/28:00 pm
OMA
- CLT
1 stop24h 19m
Frontier
Deal found 7/27![Frontier logo]()
$266
This CheapOair deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/710:04 pm
CLT
- OMA
1 stop22h 11m
Frontier
Tue 8/118:15 pm
OMA
- CLT
1 stop24h 04m
Frontier
Deal found 7/26![Frontier logo]()
$267
This CheapOair deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/195:21 pm
CLT
- OMA
1 stop21h 12m
Frontier
Fri 8/212:18 pm
OMA
- CLT
1 stop25h 08m
Frontier
Deal found 7/29![Frontier logo]()
$249
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/195:11 pm
GSP
- DSM
1 stop7h 33m
American Airlines
Sat 8/228:10 am
DSM
- GSP
1 stop5h 37m
American Airlines
Deal found 7/27![American Airlines logo]()
$325
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/208:10 am
SAV
- DSM
1 stop5h 10m
United Airlines
Mon 8/241:21 pm
DSM
- SAV
1 stop6h 58m
United Airlines
Deal found 7/28![United Airlines logo]()
$325
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:20 pm
SAV
- DSM
1 stop4h 50m
Southwest
Tue 8/257:15 am
DSM
- SAV
2 stops11h 00m
Southwest
Deal found 7/28![Southwest logo]()
$330
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:10 am
CLT
- DSM
1 stop4h 15m
Southwest
Mon 8/315:40 am
DSM
- CLT
1 stop4h 30m
Southwest
Deal found 7/26![Southwest logo]()
$321
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:08 am
MYR
- DSM
1 stop5h 16m
American Airlines
Thu 8/275:10 pm
DSM
- MYR
1 stop4h 28m
American Airlines
Deal found 7/28![American Airlines logo]()
$325
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/269:52 pm
CLT
- DSM
2 stops23h 02m
Multiple Airlines
Sun 8/301:55 pm
DSM
- CLT
1 stop17h 56m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$304
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/268:05 am
CLT
- OMA
1 stop4h 35m
Southwest
Wed 9/23:05 pm
OMA
- CLT
1 stop5h 05m
Southwest
Deal found 7/29![Southwest logo]()
$321
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/262:56 pm
CLT
- OMA
Nonstop2h 34m
American Airlines
Wed 9/26:14 am
OMA
- CLT
Nonstop2h 36m
American Airlines
Deal found 7/27![American Airlines logo]()
$323
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/299:52 pm
CLT
- DSM
2 stops23h 02m
Multiple Airlines
Sun 9/61:58 pm
DSM
- CLT
1 stop17h 53m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$315
One-way flights from South Carolina to IowaSearch for one-way flight options from South Carolina to Iowa. Find affordable one-way fares based on user searches. Data last updated July 30, 2026.
Search for one-way flight options from South Carolina to Iowa. Find affordable one-way fares based on user searches. Data last updated July 30, 2026.
This CheapOair deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/295:21 pm
CLT
- OMA
1 stop21h 12m
Frontier
Deal found 7/30![Frontier logo]()
$122
This CheapOair deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:44 pm
CLT
- OMA
1 stop25h 02m
Frontier
Deal found 7/29![Frontier logo]()
$133
This CheapOair deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/265:21 pm
CLT
- OMA
1 stop21h 12m
Frontier
Deal found 7/27![Frontier logo]()
$134
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:59 pm
GSP
- DSM
1 stop27h 14m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$138
This Trip.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1210:04 pm
CLT
- OMA
1 stop22h 11m
Frontier
Deal found 7/27![Frontier logo]()
$138
This CheapOair deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/97:46 pm
CLT
- OMA
1 stop25h 00m
Frontier
Deal found 7/28![Frontier logo]()
$139
This CheapOair deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:54 pm
CLT
- OMA
1 stop23h 40m
Frontier
Deal found 7/26![Frontier logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:46 pm
CLT
- DSM
2 stops19h 13m
Multiple Airlines
Deal found 7/28![Multiple Airlines logo]()
$143
This Trip.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/265:21 pm
CLT
- CID
1 stop21h 22m
Frontier
Deal found 7/27![Frontier logo]()
$144
This Trip.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/295:21 pm
CLT
- CID
1 stop21h 22m
Frontier
Deal found 7/30![Frontier logo]()
$145
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2711:50 am
CLT
- OMA
2 stops33h 26m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$148
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/269:52 pm
CLT
- DSM
2 stops23h 02m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$149
Find flight deals from South Carolina to Iowa
Keep the following information in mind while searching for South Carolina to Iowa flight deals. Data was last updated July 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $249 (CheapOair) |
One-way from | $122 (CheapOair) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2026.
Use the filters below to find and compare flights from South Carolina to Iowa that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GreenvilleDes Moines
GSP - DSM
GSPDSM
Greenville
Thu 9/10
7:59 pm-10:08 pm
1 stop27h 09m
Des Moines
Mon 9/14
10:24 am-6:10 pm
1 stop6h 46m
$297
CharlotteDes Moines
CLT - DSM
CLTDSM
Charlotte Douglas
Wed 9/30
8:05 am-11:50 am
1 stop4h 45m
Des Moines
Tue 10/6
5:35 am-10:40 am
1 stop4h 05m
$321
CharlotteDes Moines
CLT - DSM
CLTDSM
Charlotte Douglas
Wed 9/2
8:05 am-11:50 am
1 stop4h 45m
Des Moines
Wed 9/9
6:10 am-11:55 am
1 stop4h 45m
$321
CharlotteDes Moines
CLT - DSM
CLTDSM
Charlotte Douglas
Wed 9/23
8:05 am-11:50 am
1 stop4h 45m
Des Moines
Tue 9/29
6:10 am-11:55 am
1 stop4h 45m
$321
CharlotteOmaha
CLT - OMA
CLTOMA
Charlotte Douglas
Mon 10/26
7:25 pm-11:30 pm
1 stop5h 05m
Omaha Eppley Airfield
Thu 10/29
4:00 pm-9:45 pm
1 stop4h 45m
$321
Myrtle BeachDes Moines
MYR - DSM
MYRDSM
Myrtle Beach Intl
Wed 9/30
6:30 am-12:04 pm
1 stop6h 34m
Des Moines
Mon 10/5
11:22 am-7:27 pm
1 stop7h 05m
$325
GreenvilleOmaha
GSP - OMA
GSPOMA
Greenville
Wed 9/2
6:30 am-10:22 am
1 stop4h 52m
Omaha Eppley Airfield
Sat 9/5
7:25 am-7:05 pm
2 stops10h 40m
$330
CharlotteDes Moines
CLT - DSM
CLTDSM
Charlotte Douglas
Sat 9/5
7:55 am-11:30 am
1 stop4h 35m
Des Moines
Sun 9/6
6:05 am-5:15 pm
1 stop10h 10m
$331
CharlotteOmaha
CLT - OMA
CLTOMA
Charlotte Douglas
Tue 10/27
1:10 pm-10:05 pm
2 stops9h 55m
Omaha Eppley Airfield
Fri 10/30
5:05 am-10:35 am
1 stop4h 30m
$331
CharlotteOmaha
CLT - OMA
CLTOMA
Charlotte Douglas
Wed 8/26
1:30 pm-9:45 pm
2 stops9h 15m
Omaha Eppley Airfield
Wed 9/2
7:30 am-7:00 pm
2 stops10h 30m
$331
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Iowa
Have a flexible travel schedule? Discover the best time to fly to Iowa from South Carolina with our price prediction graph.
CLT-OMA
CLT-DSM
SAV-DSM
GSP-DSM
MYR-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Iowa
USSC-USIA
CLT-OMA
CLT-DSM
SAV-DSM
GSP-DSM
What is the cheapest month to book a flight from South Carolina to Iowa?
Currently, February is the cheapest month in which you can book a flight from South Carolina to Iowa (average of $340). Flying from South Carolina to Iowa in December is currently the most expensive (average of $602). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from South Carolina to Iowa?
Airfare is below average for this route at the moment.
South Carolina to Iowa flights typically cost between $354 and $718 in October.The cheapest round-trip price found within the last 5 days was $252 on Multiple Airlines (Oct 1-Oct 5).
Reviews of airlines servicing Iowa
Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated July 30, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from South Carolina to Iowa have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Comfort
7.8
Boarding
8.1
Entertainment
7.8
Overall
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Comfort
7.8
Boarding
8.1
Entertainment
7.8
Overall
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Comfort
7.8
Boarding
8.1
Entertainment
7.8
Overall
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Comfort
7.8
Boarding
8.1
Entertainment
7.8
Overall
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for South Carolina to Iowa
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Iowa by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Iowa by cabin class
Find flights from South Carolina to Iowa, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Iowa flights
Browse other South Carolina and Iowa flight options. Last updated on July 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Iowa
Find the right flight back to South Carolina after your stay in Iowa
South Carolina to Iowa flights
Consider these flights traveling from South Carolina to Iowa.
Top 3 airlines flying from South Carolina to Iowa
Discover the top 3 airlines that operate flights from South Carolina to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$233 | Average$400 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$250 | Average$420 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$326 | Average$543 | FlexibilityNo cancel fee | On-time69% |