HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$115+ Cheap flights from Iowa to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/23. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Jul 8 — Jul 151
Tue 7/8
Tue 7/15
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Iowa to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Iowa to South Carolina

Keep the following information in mind while searching for Iowa to South Carolina flight deals. Data was last updated July 3, 2025.

Round-trip from

$210
(Mytrip)

One-way from

$118
(Southwest)

Popular in

June

Cheapest in

September

Average price

$410
From Iowa to South Carolina
Search Deals
One-way flight from Iowa to South Carolina
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($46 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2025
Search Deals

Find flight deals from Iowa to South Carolina

Cheapest flights from Iowa to South Carolina
Explore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.

This Mytrip deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/287:59 pmOMA - CLT
1 stop19h 38mFrontier
Sun 8/315:32 pmCLT - OMA
1 stop27h 18mFrontier
Deal found 7/3$210
This Mytrip deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/49:39 amDSM - CLT
1 stop11h 37mMultiple Airlines
Fri 8/89:24 amCLT - DSM
1 stop9h 41mMultiple Airlines
Deal found 7/3$223
This Mytrip deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/186:52 pmCID - CLT
1 stop12h 34mMultiple Airlines
Mon 7/219:24 amCLT - CID
1 stop4h 42mMultiple Airlines
Deal found 7/3$228
This Southwest deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/147:00 amDSM - CLT
1 stop7h 15mSouthwest
Tue 8/195:25 pmCLT - DSM
1 stop5h 55mSouthwest
Deal found 7/1$236
This Southwest deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2412:25 pmOMA - CLT
1 stop4h 35mSouthwest
Mon 9/295:05 pmCLT - OMA
1 stop6h 20mSouthwest
Deal found 7/1$236
This Delta deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/276:30 pmDSM - CHS
1 stop4h 21mDelta
Mon 9/15:15 amCHS - DSM
1 stop6h 23mDelta
Deal found 7/1$237
This Delta deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/265:57 amCID - CHS
1 stop4h 53mDelta
Sat 8/3011:41 amCHS - CID
1 stop4h 52mDelta
Deal found 7/2$249
This Delta deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/237:00 amCID - SAV
1 stop6h 37mDelta
Tue 8/265:05 pmSAV - CID
1 stop6h 50mDelta
Deal found 7/2$249
This United Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/166:37 amCID - SAV
2 stops9h 56mUnited Airlines
Sun 7/204:45 pmSAV - CID
1 stop5h 41mUnited Airlines
Deal found 7/1$264
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2912:34 pmCID - SAV
1 stop5h 21mAmerican Airlines
Sat 8/27:36 amSAV - CID
1 stop5h 28mAmerican Airlines
Deal found 6/30$266
This Flightnetwork deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flightnetwork is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/256:52 pmCID - CHS
1 stop25h 01mMultiple Airlines
Mon 7/289:38 amCHS - CID
1 stop9h 24mMultiple Airlines
Deal found 7/1$267
This American Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/131:40 pmDSM - CHS
2 stops8h 17mAmerican Airlines
Mon 9/155:36 pmCHS - DSM
2 stops6h 52mAmerican Airlines
Deal found 7/3$269

Cheapflights Fare Finder

Customize your flight search to find flights from Iowa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 3, 2025.
Use the filters below to find and compare flights from Iowa to South Carolina that are best for you.

Fly from

Iowa

Fly to

South Carolina

Route

Depart

Return

Price

OmahaCharlotte

OMA - CLT

OMACLT

Omaha Eppley Airfield

Thu 8/28

7:59 pm-4:37 pm

1 stop19h 38m

Charlotte Douglas

Sun 8/31

5:32 pm-7:50 pm

1 stop27h 18m

$210

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Mon 8/4

9:39 am-10:16 pm

1 stop11h 37m

Charlotte Douglas

Fri 8/8

9:24 am-6:05 pm

1 stop9h 41m

$223

Cedar RapidsCharlotte

CID - CLT

CIDCLT

Cedar Rapids

Fri 7/18

6:52 pm-8:26 am

1 stop12h 34m

Charlotte Douglas

Mon 7/21

9:24 am-1:06 pm

1 stop4h 42m

$228

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Thu 8/14

7:00 am-3:15 pm

1 stop7h 15m

Charlotte Douglas

Tue 8/19

5:25 pm-10:20 pm

1 stop5h 55m

$236

OmahaCharlotte

OMA - CLT

OMACLT

Omaha Eppley Airfield

Wed 9/24

12:25 pm-6:00 pm

1 stop4h 35m

Charlotte Douglas

Mon 9/29

5:05 pm-10:25 pm

1 stop6h 20m

$236

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 8/27

6:30 pm-11:51 pm

1 stop4h 21m

Charleston

Mon 9/1

5:15 am-10:38 am

1 stop6h 23m

$237

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

Tue 8/26

5:57 am-11:50 am

1 stop4h 53m

Charleston

Sat 8/30

11:41 am-3:33 pm

1 stop4h 52m

$249

Cedar RapidsSavannah

CID - SAV

CIDSAV

Cedar Rapids

Sat 8/23

7:00 am-2:37 pm

1 stop6h 37m

Savannah/Hilton Head

Tue 8/26

5:05 pm-10:55 pm

1 stop6h 50m

$249

Cedar RapidsSavannah

CID - SAV

CIDSAV

Cedar Rapids

Wed 7/16

6:37 am-5:33 pm

2 stops9h 56m

Savannah/Hilton Head

Sun 7/20

4:45 pm-9:26 pm

1 stop5h 41m

$264

Cedar RapidsSavannah

CID - SAV

CIDSAV

Cedar Rapids

Tue 7/29

12:34 pm-6:55 pm

1 stop5h 21m

Savannah/Hilton Head

Sat 8/2

7:36 am-12:04 pm

1 stop5h 28m

$266

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/2

Showing 1-10 of 60 results
1
2
3
...
6

Best time to book a flight from Iowa to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to South Carolina

What is the cheapest month to book a flight from Iowa to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $217). Flying from Iowa to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to SC?

Find hourly flight availability from Iowa to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 3, 2025.

When flying from Iowa to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated July 3, 2025.
Get a feel of what it's like to fly with Alaska Airlines, Southwest, and Delta from Iowa to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Entertainment

7.1

Overall

8.0

Crew

8.5

Food

7.1

Comfort

7.8

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Entertainment

7.1

Overall

8.0

Crew

8.5

Food

7.1

Comfort

7.8

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Southwest
8.0
Very good
4,266 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Entertainment

7.1

Overall

8.0

Crew

8.5

Food

7.1

Comfort

7.8

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Delta
8.0
Very good
7,982 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Entertainment

7.1

Overall

8.0

Crew

8.5

Food

7.1

Comfort

7.8

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,861 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Entertainment

7.1

Overall

8.0

Crew

8.5

Food

7.1

Comfort

7.8

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Entertainment

7.1

Overall

8.0

Crew

8.5

Food

7.1

Comfort

7.8

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from Iowa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from Iowa to South Carolina one-way?

    The cheapest airline one-way is Southwest, with whom users have recently found tickets for as low as $118. However, be on the lookout for offers from American Airlines and Delta, as they are both options that can get you from Iowa to South Carolina for a low price.

  • Can I find deals for flights from Iowa to South Carolina that include hotel bookings?

    Yes. In addition to deals on Iowa to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to South Carolina.

  • Can I find deals for business class flights from Iowa to South Carolina?

    Yes. Cheapflights offers flight deals from Iowa to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $217). Flying from Iowa to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Iowa to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
Dallas/Fort Worth to LaGuardia flights
Los Angeles to John F Kennedy Intl flights
Dallas/Fort Worth to Seattle flights
Los Angeles to Seattle flights
John F Kennedy Intl to Los Angeles flights
Los Angeles to Newark flights
John F Kennedy Intl to Las Vegas flights
LaGuardia to Dallas/Fort Worth flights
John F Kennedy Intl to Miami flights
Dallas/Fort Worth to John F Kennedy Intl flights
Newark to Los Angeles flights
John F Kennedy Intl to O'Hare Intl flights
Dallas/Fort Worth to O'Hare Intl flights
Los Angeles to Honolulu flights
LaGuardia to Fort Lauderdale flights
Dallas/Fort Worth to Los Angeles flights
Newark to Fort Lauderdale flights
Atlanta to John F Kennedy Intl flights
Los Angeles to Dallas/Fort Worth flights
Los Angeles to San Francisco flights
John F Kennedy Intl to Orlando flights
Newark to O'Hare Intl flights
Dallas/Fort Worth to Las Vegas flights
LaGuardia to O'Hare Intl flights
John F Kennedy Intl to Seattle flights
San Francisco to Las Vegas flights
San Francisco to John F Kennedy Intl flights
O'Hare Intl to LaGuardia flights
John F Kennedy Intl to Atlanta flights
John F Kennedy Intl to Dallas/Fort Worth flights
Newark to Seattle flights
John F Kennedy Intl to San Francisco flights
San Francisco to Los Angeles flights
Newark to Miami flights
LaGuardia to Miami flights
Seattle to Dallas/Fort Worth flights
O'Hare Intl to John F Kennedy Intl flights
Ontario to Seattle flights
Seattle to Los Angeles flights
Dallas/Fort Worth to Newark flights
O'Hare Intl to Newark flights
O'Hare Intl to Las Vegas flights
Dallas/Fort Worth to Orlando flights
John F Kennedy Intl to Fort Lauderdale flights
Los Angeles to O'Hare Intl flights
Newark to Orlando flights
O'Hare Intl to Dallas/Fort Worth flights
Los Angeles to Las Vegas flights
Newark to Las Vegas flights
Dallas/Fort Worth to Denver flights

Top 4 airlines flying from Iowa to South Carolina

Discover the top 4 airlines that operate flights from Iowa to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$226Average$394FlexibilityNo cancel feeOn-time71%
DeltaCheapest$232Average$361FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$235Average$460FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$376Average$406FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
Site
©2025 Cheapflights