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Des Moines

$348+ Cheap flights from Tallahassee to Des Moines (TLH - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/13. Fares are subject to change and may not be available on all flights or dates of travel.
TLH — DSM
May 21 — May 281
Thu 5/21
Thu 5/28
1 adult, Economy
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Cheap flight deals from Tallahassee to Des Moines

Cheapest flights from Tallahassee to Des Moines
Explore the most affordable flight options available from Tallahassee to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 21, 2026.

This American Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:48 pm
TLH
-
DSM
1 stop5h 29m
American Airlines
Tue 6/24:48 pm
DSM
-
TLH
1 stop5h 50m
American Airlines
Deal found 4/18$403
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/237:43 pm
TLH
-
DSM
1 stop5h 34m
American Airlines
Sat 5/303:24 pm
DSM
-
TLH
1 stop5h 42m
American Airlines
Deal found 4/21$436
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/19:32 am
TLH
-
DSM
2 stops9h 50m
American Airlines
Wed 7/81:04 pm
DSM
-
TLH
2 stops9h 52m
American Airlines
Deal found 4/17$445
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/38:05 pm
TLH
-
DSM
1 stop5h 24m
American Airlines
Mon 7/61:04 pm
DSM
-
TLH
2 stops9h 52m
American Airlines
Deal found 4/17$450
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:15 am
TLH
-
DSM
1 stop7h 40m
American Airlines
Wed 4/291:25 pm
DSM
-
TLH
1 stop7h 56m
American Airlines
Deal found 4/21$467
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:53 pm
TLH
-
DSM
1 stop6h 06m
American Airlines
Sun 5/245:00 am
DSM
-
TLH
2 stops9h 02m
American Airlines
Deal found 4/20$482

Find flight deals from Tallahassee to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Tallahassee (TLH) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 21, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$403
(American Airlines)

One-way from

$348
(American Airlines)

Popular in

October

Cheapest in

August

Average price

$473
Provider with most accurate pricing for Tallahassee-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Tallahassee-Des Moines flights.
Search Deals
From Tallahassee to Des Moines
Search Deals
One-way flight from Tallahassee to Des Moines
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($88 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($29 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Tallahassee to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 21, 2026.
Use the filters below to find and compare flights from Tallahassee to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

TallahasseeDes Moines

TLH - DSM

TLHDSM

Tallahassee

Thu 5/28

7:48 pm-12:17 am

1 stop5h 29m

Des Moines

Tue 6/2

4:48 pm-11:38 pm

1 stop5h 50m

$403

TallahasseeDes Moines

TLH - DSM

TLHDSM

Tallahassee

Wed 7/1

7:48 pm-12:10 am

1 stop5h 22m

Des Moines

Wed 7/8

1:41 pm-10:35 pm

1 stop7h 54m

$403

TallahasseeDes Moines

TLH - DSM

TLHDSM

Tallahassee

Fri 7/3

8:05 pm-12:29 am

1 stop5h 24m

Des Moines

Mon 7/6

1:04 pm-11:56 pm

2 stops9h 52m

$450
Quickest round-trip

TallahasseeDes Moines

TLH - DSM

TLHDSM

Tallahassee

Tue 5/5

6:44 pm-10:34 pm

1 stop4h 50m

Des Moines

Sat 5/9

2:33 pm-7:38 pm

1 stop4h 05m

$467

TallahasseeDes Moines

TLH - DSM

TLHDSM

Tallahassee

Tue 5/5

2:35 pm-11:49 pm

2 stops10h 14m

Des Moines

Sat 5/9

7:05 am-2:54 pm

1 stop6h 49m

$472

TallahasseeDes Moines

TLH - DSM

TLHDSM

Tallahassee

Fri 5/15

6:53 pm-11:59 pm

1 stop6h 06m

Des Moines

Sun 5/24

1:37 pm-10:36 pm

1 stop7h 59m

$477

TallahasseeDes Moines

TLH - DSM

TLHDSM

Tallahassee

Sat 5/23

7:43 pm-12:17 am

1 stop5h 34m

Des Moines

Sat 5/30

9:41 am-11:59 pm

2 stops13h 18m

$531
Cheapest one-way
Quickest one-way

TallahasseeDes Moines

TLH - DSM

TLHDSM

Tallahassee

Sat 6/13

5:41 pm-10:31 pm

1 stop5h 50m

$348

TallahasseeDes Moines

TLH - DSM

TLHDSM

Tallahassee

Sun 6/14

5:41 pm-10:31 pm

1 stop5h 50m

$348

TallahasseeDes Moines

TLH - DSM

TLHDSM

Tallahassee

Sun 6/14

6:00 am-2:04 pm

2 stops9h 04m

$423

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/20

Sorted by cheapest first

Compare providers for flights from Tallahassee to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Tallahassee to Des Moines in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Tallahassee-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Tallahassee-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Tallahassee-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Tallahassee-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Tallahassee-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Tallahassee to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Tallahassee with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Tallahassee to Des Moines

How much does it cost to fly round-trip from Tallahassee to Des Moines?

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated April 21, 2026.
Get a feel of what it's like to fly with American Airlines from Tallahassee to Des Moines by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,645 reviews

Entertainment

6.9

Boarding

7.5

Food

6.4

Comfort

7.2

Crew

7.9

Overall

7.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Mar 2026

MIA - SFO

Horrible. When they power flights for other airlines there is nothing they can do to change or accommodate any changes
American Airlines
7.1
Good
11,645 reviews
American Airlines
7.1
Good
11,645 reviews

Entertainment

6.9

Boarding

7.5

Food

6.4

Comfort

7.2

Crew

7.9

Overall

7.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Mar 2026

MIA - SFO

Horrible. When they power flights for other airlines there is nothing they can do to change or accommodate any changes

Related info for your journey

Find useful and relevant information for your journey from Tallahassee to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Tallahassee to Des Moines?

    American Airlines can get you from Tallahassee to Des Moines in just under 5h 29m. Your travel time can differ by up to . Airlines will cover a distance of 927 mi.

  • What is the cheapest airline to fly from Tallahassee to Des Moines round-trip?

    Currently priced at $336, American Airlines will fly you from Tallahassee to Des Moines and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. American Airlines is priced at 37% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Tallahassee to Des Moines that include hotel bookings?

    Yes. In addition to deals on Tallahassee to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Tallahassee to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Tallahassee to Des Moines.

  • Can I find deals for business class flights from Tallahassee to Des Moines?

    Yes. Cheapflights offers flight deals from Tallahassee to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Ames
Clive
Boone
West Des Moines
Ankeny

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Top airline flying from Tallahassee to Des Moines

Discover the top airline that operate flights from Tallahassee to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$336Average$416FlexibilityNo cancel feeOn-time71%

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