$147+ Cheap flights from San Antonio to Des Moines (SAT - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/9. Fares are subject to change and may not be available on all flights or dates of travel.
SAT — DSM
Nov 18 — Nov 251
Round-trip
1 adult, Economy
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Find cheap flights from San Antonio to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Antonio to Des Moines
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Cheapest flights from San Antonio to Des MoinesExplore the most affordable flight options available from San Antonio to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 19, 2026.
Explore the most affordable flight options available from San Antonio to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 19, 2026.
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:40 pm -
1 stop5h 46m
Thu 11/197:16 pm -
1 stop4h 50m
Deal found 10/19![American Airlines logo]()
$281
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/241:50 pm -
1 stop7h 00m
Thu 1/712:15 pm -
1 stop9h 30m
Deal found 10/19![Southwest logo]()
$282
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:47 pm -
1 stop5h 32m
Wed 11/257:16 pm -
1 stop4h 50m
Deal found 10/15![American Airlines logo]()
$375
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:00 am -
1 stop4h 15m
Tue 11/107:23 am -
1 stop6h 09m
Deal found 10/15![American Airlines logo]()
$385
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/192:35 pm -
1 stop8h 25m
Tue 1/57:00 am -
1 stop7h 05m
Deal found 10/19![Southwest logo]()
$391
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/132:33 pm -
1 stop4h 42m
Sun 11/156:52 pm -
1 stop5h 41m
Deal found 10/19![Delta logo]()
$395
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/121:52 pm -
1 stop6h 44m
Thu 11/198:00 am -
2 stops7h 38m
Deal found 10/19![United Airlines logo]()
$397
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:00 am -
1 stop4h 07m
Sun 11/1511:28 am -
1 stop8h 15m
Deal found 10/16![American Airlines logo]()
$398
This Southwest deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/152:30 pm -
1 stop7h 35m
Tue 11/176:00 am -
2 stops8h 05m
Deal found 10/16![Southwest logo]()
$403
Best flights from San Antonio to Des MoinesDiscover carefully curated flight deals from San Antonio to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 19, 2026.
Discover carefully curated flight deals from San Antonio to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 19, 2026.
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:40 pm -
1 stop5h 46m
Thu 11/197:16 pm -
1 stop4h 50m
Deal found 10/19![American Airlines logo]()
$281
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/241:50 pm -
1 stop7h 00m
Thu 1/76:55 am -
2 stops8h 55m
Deal found 10/19![Southwest logo]()
$288
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/121:52 pm -
1 stop6h 44m
Thu 11/198:00 am -
2 stops7h 38m
Deal found 10/19![United Airlines logo]()
$397
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:47 pm -
1 stop5h 32m
Wed 11/257:16 pm -
1 stop4h 50m
Deal found 10/15![American Airlines logo]()
$375
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/192:35 pm -
1 stop8h 25m
Tue 1/57:00 am -
2 stops8h 35m
Deal found 10/19![Southwest logo]()
$396
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/155:00 am -
1 stop4h 07m
Tue 11/177:23 am -
1 stop6h 09m
Deal found 10/16![American Airlines logo]()
$398
This Southwest deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/152:30 pm -
1 stop7h 35m
Tue 11/176:00 am -
2 stops8h 05m
Deal found 10/16![Southwest logo]()
$403
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:00 am -
1 stop4h 07m
Sun 11/1511:28 am -
1 stop8h 15m
Deal found 10/16![American Airlines logo]()
$398
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/121:10 pm -
2 stops9h 55m
Thu 11/196:00 am -
2 stops8h 05m
Deal found 10/19![Southwest logo]()
$431
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:55 am -
2 stops7h 15m
Fri 11/134:25 pm -
2 stops7h 45m
Deal found 10/19![Southwest logo]()
$451
Last-minute flights from San Antonio to Des MoinesDiscover last-minute flight deals from San Antonio to Des Moines. Data last updated October 19, 2026 and is based on user searches.
Discover last-minute flight deals from San Antonio to Des Moines. Data last updated October 19, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:21 pm -
1 stop23h 09m
Mon 10/268:25 pm -
1 stop23h 00m
Deal found 10/17![Frontier logo]()
$415
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:00 am -
1 stop4h 15m
Tue 11/107:23 am -
1 stop6h 09m
Deal found 10/15![American Airlines logo]()
$385
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:25 am -
1 stop6h 45m
Fri 11/134:25 pm -
1 stop8h 00m
Deal found 10/19![Southwest logo]()
$441
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:40 pm -
1 stop5h 46m
Thu 11/197:16 pm -
1 stop4h 50m
Deal found 10/19![American Airlines logo]()
$281
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/121:52 pm -
1 stop6h 44m
Thu 11/198:00 am -
2 stops7h 38m
Deal found 10/19![United Airlines logo]()
$397
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/121:10 pm -
2 stops9h 55m
Thu 11/196:00 am -
2 stops8h 05m
Deal found 10/19![Southwest logo]()
$431
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/132:33 pm -
1 stop4h 42m
Sun 11/156:52 pm -
1 stop5h 41m
Deal found 10/19![Delta logo]()
$395
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:00 am -
1 stop4h 07m
Sun 11/1511:28 am -
1 stop8h 15m
Deal found 10/16![American Airlines logo]()
$398
This Southwest deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/152:30 pm -
1 stop7h 35m
Tue 11/176:00 am -
2 stops8h 05m
Deal found 10/16![Southwest logo]()
$403
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:47 pm -
1 stop5h 32m
Wed 11/257:16 pm -
1 stop4h 50m
Deal found 10/15![American Airlines logo]()
$375
One-way flights from San Antonio to Des MoinesSearch for one-way flight options from San Antonio to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 19, 2026.
Search for one-way flight options from San Antonio to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 19, 2026.
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/94:32 pm -
1 stop6h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![Delta logo]()
$147
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/167:06 pm -
1 stop3h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![American Airlines logo]()
$193
This CheapOair deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:20 pm -
1 stop23h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/15![Frontier logo]()
$200
This Southwest deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/215:20 am -
1 stop11h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Southwest logo]()
$211
This Delta deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/236:45 am -
1 stop5h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/18![Delta logo]()
$219
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/94:19 pm -
2 stops7h 23m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![United Airlines logo]()
$234
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/2311:25 am -
2 stops7h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/15![American Airlines logo]()
$241
This Southwest deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/161:00 pm -
2 stops7h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Southwest logo]()
$250
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:45 am -
2 stops7h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/15![United Airlines logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/168:20 pm -
3 stops40h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Multiple Airlines logo]()
$340
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/299:25 am -
3 stops28h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/15![Multiple Airlines logo]()
$387
Find flight deals from San Antonio to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from San Antonio (SAT) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 19, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $281 (American Airlines) |
One-way from | $147 (Delta) |
Popular in | January |
Cheapest in | November |
Average price | $806 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Antonio to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 19, 2026.
Use the filters below to find and compare flights from San Antonio to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
San AntonioDes Moines
SAT San Antonio - DSM Des Moines
SATDSM
San Antonio
Mon 11/9
4:32 pm-10:35 pm
1 stop6h 03m
Des Moines
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$147
San AntonioDes Moines
SAT San Antonio - DSM Des Moines
SATDSM
San Antonio
Sat 1/23
11:25 am-5:29 pm
1 stop6h 04m
Des Moines
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$193
San AntonioDes Moines
SAT San Antonio - DSM Des Moines
SATDSM
San Antonio
Sun 2/21
5:20 am-5:10 pm
1 stop11h 50m
Des Moines
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$211
Quickest round-trip
San AntonioDes Moines
SAT San Antonio - DSM Des Moines
SATDSM
San Antonio
Sat 1/23
6:45 am-12:13 pm
1 stop5h 28m
Des Moines
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$219
San AntonioDes Moines
SAT San Antonio - DSM Des Moines
SATDSM
San Antonio
Mon 11/9
4:19 pm-11:42 pm
2 stops7h 23m
Des Moines
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$234
San AntonioDes Moines
SAT San Antonio - DSM Des Moines
SATDSM
San Antonio
Mon 11/16
1:00 pm-8:50 pm
2 stops7h 50m
Des Moines
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$250
San AntonioDes Moines
SAT San Antonio - DSM Des Moines
SATDSM
San Antonio
Thu 10/29
11:45 am-7:16 pm
2 stops7h 31m
Des Moines
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$274
San AntonioDes Moines
SAT San Antonio - DSM Des Moines
SATDSM
San Antonio
Thu 11/12
6:40 pm-12:26 am
1 stop5h 46m
Des Moines
Thu 11/19
7:16 pm-12:06 am
1 stop4h 50m
$281
San AntonioDes Moines
SAT San Antonio - DSM Des Moines
SATDSM
San Antonio
Thu 12/24
1:50 pm-8:50 pm
1 stop7h 00m
Des Moines
Thu 1/7
6:55 am-3:50 pm
2 stops8h 55m
$288
San AntonioDes Moines
SAT San Antonio - DSM Des Moines
SATDSM
San Antonio
Mon 11/16
8:20 pm-1:05 pm
3 stops40h 45m
Des Moines
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$340
Showing 1-10 of 20 resultsSorted by cheapest first
Compare providers for flights from San Antonio to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Antonio to Des Moines in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on San Antonio-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Antonio-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Antonio-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Antonio-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Antonio-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Antonio to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from San Antonio with our price prediction graph.
SAT-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Antonio to Des Moines
What is the cheapest month to book a flight from San Antonio to Des Moines?
Currently, November is the cheapest month in which you can book a flight from San Antonio to Des Moines (average of $283). Flying from San Antonio to Des Moines in January is currently the most expensive (average of $830). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from San Antonio to Des Moines?
Airfare is below average for this route at the moment.
San Antonio to Des Moines flights typically cost between $616 and $840 in November.The cheapest round-trip price found within the last 5 days was $281 on American Airlines (Nov 12-Nov 19).
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated October 19, 2026.
See what other customers who have flown with United Airlines and American Airlines from San Antonio to Des Moines have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.1
Crew
8.1
Overall
7.3
Boarding
7.7
Comfort
7.3
Food
6.7
Reviews
1 / 20
8.0
ExcellentAnonymous,Apr 2026
DFW - EWR
Entertainment
7.1
Crew
8.1
Overall
7.3
Boarding
7.7
Comfort
7.3
Food
6.7
Reviews
1 / 20
8.0
ExcellentAnonymous,Apr 2026
DFW - EWR
Entertainment
7.1
Crew
8.1
Overall
7.3
Boarding
7.7
Comfort
7.3
Food
6.7
Reviews
1 / 20
8.0
ExcellentAnonymous,Apr 2026
DFW - EWR
Related info for your journey
Find useful and relevant information for your journey from San Antonio to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
West Des Moines
Ames
Johnston
Boone
Norwalk
Ankeny
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Top 2 airlines flying from San Antonio to Des Moines
Discover the top 2 airlines that operate flights from San Antonio to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 19, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$310 | Average$507 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$313 | Average$442 | FlexibilityNo cancel fee | On-time69% |