$126+ Cheap flights from San Antonio to Des Moines (SAT - DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/21. Fares are subject to change and may not be available on all flights or dates of travel.
SAT — DSM
Jul 4 — Jul 111
Round-trip
1 adult, Economy
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Find cheap flights from San Antonio to Des Moines with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from San Antonio to Des MoinesExplore the most affordable flight options available from San Antonio to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 4, 2026.
Explore the most affordable flight options available from San Antonio to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 4, 2026.
This United Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/115:30 am
SAT
- DSM
1 stop5h 22m
United Airlines
Wed 8/126:00 am
DSM
- SAT
1 stop5h 52m
United Airlines
Deal found 6/1![United Airlines logo]()
$313
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/16:05 am
SAT
- DSM
1 stop7h 16m
American Airlines
Tue 7/76:33 pm
DSM
- SAT
1 stop5h 37m
American Airlines
Deal found 6/3![American Airlines logo]()
$355
This Southwest deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/62:20 pm
SAT
- DSM
1 stop7h 30m
Southwest
Thu 10/84:30 pm
DSM
- SAT
1 stop7h 45m
Southwest
Deal found 6/2![Southwest logo]()
$376
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/295:35 pm
SAT
- DSM
1 stop6h 23m
American Airlines
Sat 8/11:41 pm
DSM
- SAT
1 stop8h 38m
American Airlines
Deal found 6/3![American Airlines logo]()
$381
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/245:01 am
SAT
- DSM
1 stop4h 10m
American Airlines
Mon 6/295:30 am
DSM
- SAT
1 stop4h 29m
American Airlines
Deal found 6/3![American Airlines logo]()
$391
This American Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/65:00 am
SAT
- DSM
1 stop4h 01m
American Airlines
Mon 8/104:13 pm
DSM
- SAT
1 stop6h 37m
American Airlines
Deal found 6/4![American Airlines logo]()
$397
This Southwest deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:45 am
SAT
- DSM
1 stop9h 20m
Southwest
Tue 7/73:45 pm
DSM
- SAT
2 stops6h 40m
Southwest
Deal found 6/2![Southwest logo]()
$402
This Delta deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/132:26 pm
SAT
- DSM
1 stop6h 42m
Delta
Thu 7/162:45 pm
DSM
- SAT
1 stop6h 41m
Delta
Deal found 6/3![Delta logo]()
$407
Best flights from San Antonio to Des MoinesDiscover carefully curated flight deals from San Antonio to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 4, 2026.
Discover carefully curated flight deals from San Antonio to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 4, 2026.
This United Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/115:30 am
SAT
- DSM
1 stop5h 22m
United Airlines
Wed 8/126:15 am
DSM
- SAT
1 stop4h 21m
United Airlines
Deal found 5/31![United Airlines logo]()
$313
This Delta deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/2612:05 pm
SAT
- DSM
1 stop5h 49m
Delta
Tue 6/305:35 am
DSM
- SAT
1 stop8h 00m
Delta
Deal found 6/2![Delta logo]()
$391
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/3012:55 pm
SAT
- DSM
2 stops9h 50m
Southwest
Sun 7/512:05 pm
DSM
- SAT
2 stops12h 50m
Southwest
Deal found 6/1![Southwest logo]()
$464
This Delta deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/24:15 pm
SAT
- DSM
1 stop6h 14m
Delta
Sun 10/410:57 am
DSM
- SAT
1 stop6h 13m
Delta
Deal found 5/30![Delta logo]()
$407
This Southwest deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/155:20 am
SAT
- DSM
1 stop7h 30m
Southwest
Fri 6/194:40 pm
DSM
- SAT
1 stop7h 25m
Southwest
Deal found 5/30![Southwest logo]()
$487
Last-minute flights from San Antonio to Des MoinesDiscover last-minute flight deals from San Antonio to Des Moines. Data last updated June 4, 2026 and is based on user searches.
Discover last-minute flight deals from San Antonio to Des Moines. Data last updated June 4, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/245:01 am
SAT
- DSM
1 stop4h 10m
American Airlines
Mon 6/295:30 am
DSM
- SAT
1 stop4h 29m
American Airlines
Deal found 6/3![American Airlines logo]()
$391
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/248:56 pm
SAT
- DSM
1 stop22h 50m
Multiple Airlines
Mon 6/299:56 pm
DSM
- SAT
2 stops45h 00m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$438
This American Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/266:24 pm
SAT
- DSM
1 stop6h 11m
American Airlines
Mon 6/294:48 pm
DSM
- SAT
1 stop6h 17m
American Airlines
Deal found 6/1![American Airlines logo]()
$427
This Southwest deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/265:20 am
SAT
- DSM
1 stop7h 30m
Southwest
Tue 6/303:45 pm
DSM
- SAT
2 stops6h 35m
Southwest
Deal found 6/2![Southwest logo]()
$428
This Southwest deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/265:20 am
SAT
- DSM
1 stop7h 30m
Southwest
Mon 6/294:40 pm
DSM
- SAT
2 stops8h 20m
Southwest
Deal found 6/2![Southwest logo]()
$432
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/3012:55 pm
SAT
- DSM
2 stops9h 50m
Southwest
Sun 7/56:10 am
DSM
- SAT
1 stop4h 45m
Southwest
Deal found 6/1![Southwest logo]()
$443
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/16:05 am
SAT
- DSM
1 stop7h 16m
American Airlines
Tue 7/76:33 pm
DSM
- SAT
1 stop5h 37m
American Airlines
Deal found 6/3![American Airlines logo]()
$355
This Southwest deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:45 am
SAT
- DSM
1 stop9h 20m
Southwest
Tue 7/73:45 pm
DSM
- SAT
2 stops6h 40m
Southwest
Deal found 6/2![Southwest logo]()
$402
This Delta deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/132:26 pm
SAT
- DSM
1 stop6h 42m
Delta
Thu 7/162:45 pm
DSM
- SAT
1 stop6h 41m
Delta
Deal found 6/3![Delta logo]()
$407
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/295:35 pm
SAT
- DSM
1 stop6h 23m
American Airlines
Sat 8/11:41 pm
DSM
- SAT
1 stop8h 38m
American Airlines
Deal found 6/3![American Airlines logo]()
$381
This Delta deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/315:20 am
SAT
- DSM
1 stop5h 25m
Delta
Mon 8/36:35 pm
DSM
- SAT
1 stop5h 53m
Delta
Deal found 6/1![Delta logo]()
$417
One-way flights from San Antonio to Des MoinesSearch for one-way flight options from San Antonio to Des Moines. Find affordable one-way fares based on user searches. Data last updated June 4, 2026.
Search for one-way flight options from San Antonio to Des Moines. Find affordable one-way fares based on user searches. Data last updated June 4, 2026.
This Booking.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/217:39 pm
SAT
- DSM
1 stop17h 55m
Frontier
Deal found 6/3![Frontier logo]()
$126
This Booking.com deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/167:51 pm
SAT
- DSM
1 stop17h 40m
Frontier
Deal found 5/30![Frontier logo]()
$147
This Delta deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:05 am
SAT
- DSM
1 stop8h 00m
Delta
Deal found 6/3![Delta logo]()
$178
This Southwest deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:10 am
SAT
- DSM
2 stops8h 55m
Southwest
Deal found 6/3![Southwest logo]()
$183
This Southwest deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/49:50 am
SAT
- DSM
1 stop4h 40m
Southwest
Deal found 6/3![Southwest logo]()
$204
This United Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/45:30 am
SAT
- DSM
2 stops8h 57m
United Airlines
Deal found 6/3![United Airlines logo]()
$209
This American Airlines deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/195:01 am
SAT
- DSM
1 stop3h 59m
American Airlines
Deal found 5/30![American Airlines logo]()
$244
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/44:53 pm
SAT
- DSM
3 stops17h 14m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$245
This United Airlines deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/165:30 am
SAT
- DSM
2 stops7h 06m
United Airlines
Deal found 5/30![United Airlines logo]()
$249
This Southwest deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/192:10 pm
SAT
- DSM
2 stops9h 20m
Southwest
Deal found 5/30![Southwest logo]()
$260
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/222:48 pm
SAT
- DSM
2 stops9h 13m
American Airlines
Deal found 6/3![American Airlines logo]()
$273
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/202:48 pm
SAT
- DSM
2 stops9h 13m
American Airlines
Deal found 6/3![American Airlines logo]()
$285
Find flight deals from San Antonio to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from San Antonio (SAT) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $313 (United Airlines) |
One-way from | $126 (Booking.com) |
Popular in | May |
Cheapest in | September |
Average price | $426 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Antonio to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 4, 2026.
Use the filters below to find and compare flights from San Antonio to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
San AntonioDes Moines
SAT - DSM
SATDSM
San Antonio
Tue 8/11
5:30 am-10:52 am
1 stop5h 22m
Des Moines
Wed 8/12
6:15 am-10:36 am
1 stop4h 21m
$313
San AntonioDes Moines
SAT - DSM
SATDSM
San Antonio
Fri 6/26
12:05 pm-5:54 pm
1 stop5h 49m
Des Moines
Tue 6/30
5:35 am-1:35 pm
1 stop8h 00m
$391
San AntonioDes Moines
SAT - DSM
SATDSM
San Antonio
Fri 10/2
4:15 pm-10:29 pm
1 stop6h 14m
Des Moines
Sun 10/4
10:57 am-5:10 pm
1 stop6h 13m
$407
San AntonioDes Moines
SAT - DSM
SATDSM
San Antonio
Tue 6/30
12:55 pm-10:45 pm
2 stops9h 50m
Des Moines
Sun 7/5
12:05 pm-12:55 am
2 stops12h 50m
$464
San AntonioDes Moines
SAT - DSM
SATDSM
San Antonio
Mon 6/15
5:20 am-12:50 pm
1 stop7h 30m
Des Moines
Fri 6/19
4:40 pm-12:05 am
1 stop7h 25m
$487
Cheapest one-way
San AntonioDes Moines
SAT - DSM
SATDSM
San Antonio
Tue 6/16
7:51 pm-1:31 pm
1 stop17h 40m
$147
San AntonioDes Moines
SAT - DSM
SATDSM
San Antonio
Tue 7/21
6:10 am-3:05 pm
2 stops8h 55m
$183
San AntonioDes Moines
SAT - DSM
SATDSM
San Antonio
Thu 7/23
4:15 pm-10:29 pm
1 stop6h 14m
$204
San AntonioDes Moines
SAT - DSM
SATDSM
San Antonio
Sat 7/4
9:50 am-2:30 pm
1 stop4h 40m
$204
San AntonioDes Moines
SAT - DSM
SATDSM
San Antonio
Fri 7/24
6:05 am-2:05 pm
1 stop8h 00m
$204
Showing 1-10 of 17 resultsSorted by cheapest first
Compare providers for flights from San Antonio to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Antonio to Des Moines in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on San Antonio-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Antonio-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Antonio-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Antonio-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Antonio-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Antonio to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from San Antonio with our price prediction graph.
SAT-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Antonio to Des Moines
What is the cheapest month to book a flight from San Antonio to Des Moines?
Currently, September is the cheapest month in which you can book a flight from San Antonio to Des Moines (average of $297). Flying from San Antonio to Des Moines in May is currently the most expensive (average of $667). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from San Antonio to Des Moines?
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated June 4, 2026.
See what other customers who have flown with United Airlines and American Airlines from San Antonio to Des Moines have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.1
Boarding
7.7
Crew
8.1
Overall
7.4
Food
6.6
Comfort
7.3
Reviews
1 / 20
4.0
OkayDynasty,May 2026
LAX - EWR
Entertainment
7.1
Boarding
7.7
Crew
8.1
Overall
7.4
Food
6.6
Comfort
7.3
Reviews
1 / 20
4.0
OkayDynasty,May 2026
LAX - EWR
Entertainment
7.1
Boarding
7.7
Crew
8.1
Overall
7.4
Food
6.6
Comfort
7.3
Reviews
1 / 20
4.0
OkayDynasty,May 2026
LAX - EWR
Related info for your journey
Find useful and relevant information for your journey from San Antonio to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Johnston
Ames
Clive
Boone
West Des Moines
Ankeny
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San Antonio and Des Moines flights
Browse other San Antonio and Des Moines flight options. Last updated on June 4, 2026.
Other flights from San Antonio
Browse through other flights departing from San Antonio. Flights are based on user searches made on Cheapflights and were last updated on June 4, 2026.
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Top 2 airlines flying from San Antonio to Des Moines
Discover the top 2 airlines that operate flights from San Antonio to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$263 | Average$436 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$276 | Average$412 | FlexibilityNo cancel fee | On-time71% |