$204+ Cheap flights from San Antonio to Des Moines (SAT - DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/11. Fares are subject to change and may not be available on all flights or dates of travel.
SAT — DSM
May 9 — May 161
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from San Antonio to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Antonio to Des Moines
Cheapest
Best
Last-minute
One-way
Cheapest flights from San Antonio to Des MoinesExplore the most affordable flight options available from San Antonio to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 9, 2026.
Explore the most affordable flight options available from San Antonio to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/177:54 pm
SAT
- DSM
1 stop17h 37m
Multiple Airlines
Wed 5/208:05 pm
DSM
- SAT
2 stops24h 09m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$363
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/216:15 am
SAT
- DSM
1 stop6h 55m
Southwest
Thu 5/284:20 pm
DSM
- SAT
1 stop8h 10m
Southwest
Deal found 4/8![Southwest logo]()
$365
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/175:25 am
SAT
- DSM
1 stop5h 43m
Delta
Wed 5/205:27 am
DSM
- SAT
1 stop8h 04m
Delta
Deal found 4/5![Delta logo]()
$371
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1711:30 am
SAT
- DSM
1 stop10h 50m
Southwest
Wed 5/205:30 am
DSM
- SAT
1 stop7h 25m
Southwest
Deal found 4/5![Southwest logo]()
$386
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:05 am
SAT
- DSM
1 stop7h 15m
Southwest
Sat 5/305:35 am
DSM
- SAT
2 stops9h 15m
Southwest
Deal found 4/8![Southwest logo]()
$391
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/232:00 pm
SAT
- DSM
1 stop8h 45m
Southwest
Sun 6/2812:05 pm
DSM
- SAT
2 stops12h 45m
Southwest
Deal found 4/5![Southwest logo]()
$397
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/177:54 pm
SAT
- DSM
1 stop17h 37m
Multiple Airlines
Thu 5/218:00 am
DSM
- SAT
2 stops36h 14m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$398
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/135:20 am
SAT
- DSM
1 stop7h 30m
Southwest
Sat 7/186:10 am
DSM
- SAT
1 stop4h 55m
Southwest
Deal found 4/8![Southwest logo]()
$407
Best flights from San Antonio to Des MoinesDiscover carefully curated flight deals from San Antonio to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 9, 2026.
Discover carefully curated flight deals from San Antonio to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 9, 2026.
This United Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/234:35 pm
SAT
- DSM
1 stop7h 09m
United Airlines
Sat 5/305:50 am
DSM
- SAT
1 stop6h 53m
United Airlines
Deal found 4/8![United Airlines logo]()
$365
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/216:15 am
SAT
- DSM
1 stop6h 55m
Southwest
Thu 5/284:20 pm
DSM
- SAT
2 stops6h 40m
Southwest
Deal found 4/8![Southwest logo]()
$370
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/175:25 am
SAT
- DSM
1 stop5h 43m
Delta
Thu 5/216:41 pm
DSM
- SAT
1 stop6h 03m
Delta
Deal found 4/5![Delta logo]()
$386
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/177:54 pm
SAT
- DSM
1 stop17h 37m
Multiple Airlines
Thu 5/218:00 am
DSM
- SAT
2 stops36h 14m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$398
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:05 am
SAT
- DSM
1 stop7h 15m
Southwest
Sat 5/305:35 am
DSM
- SAT
2 stops9h 15m
Southwest
Deal found 4/8![Southwest logo]()
$391
This Delta deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:05 am
SAT
- DSM
1 stop7h 59m
Delta
Mon 7/132:48 pm
DSM
- SAT
1 stop7h 31m
Delta
Deal found 4/3![Delta logo]()
$407
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/51:11 pm
SAT
- DSM
1 stop7h 05m
United Airlines
Wed 5/69:06 am
DSM
- SAT
1 stop7h 51m
United Airlines
Deal found 4/4![United Airlines logo]()
$415
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/132:21 pm
SAT
- DSM
1 stop8h 08m
Delta
Thu 7/166:38 pm
DSM
- SAT
1 stop5h 46m
Delta
Deal found 4/4![Delta logo]()
$407
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/24:39 pm
SAT
- DSM
1 stop7h 05m
United Airlines
Tue 5/55:30 am
DSM
- SAT
1 stop7h 26m
United Airlines
Deal found 4/5![United Airlines logo]()
$426
Last-minute flights from San Antonio to Des MoinesDiscover last-minute flight deals from San Antonio to Des Moines. Data last updated April 9, 2026 and is based on user searches.
Discover last-minute flight deals from San Antonio to Des Moines. Data last updated April 9, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/51:11 pm
SAT
- DSM
1 stop7h 05m
United Airlines
Wed 5/69:06 am
DSM
- SAT
1 stop7h 51m
United Airlines
Deal found 4/4![United Airlines logo]()
$415
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/83:20 pm
SAT
- DSM
1 stop6h 35m
Southwest
Sun 5/247:05 am
DSM
- SAT
1 stop4h 55m
Southwest
Deal found 4/8![Southwest logo]()
$407
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/177:54 pm
SAT
- DSM
1 stop17h 37m
Multiple Airlines
Wed 5/208:05 pm
DSM
- SAT
2 stops24h 09m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$363
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/175:25 am
SAT
- DSM
1 stop5h 43m
Delta
Wed 5/205:27 am
DSM
- SAT
1 stop8h 04m
Delta
Deal found 4/5![Delta logo]()
$371
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/175:25 am
SAT
- DSM
1 stop5h 43m
Delta
Thu 5/216:41 pm
DSM
- SAT
1 stop6h 03m
Delta
Deal found 4/5![Delta logo]()
$386
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/177:54 pm
SAT
- DSM
1 stop17h 37m
Multiple Airlines
Thu 5/218:00 am
DSM
- SAT
2 stops36h 14m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$398
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/216:15 am
SAT
- DSM
1 stop6h 55m
Southwest
Thu 5/284:20 pm
DSM
- SAT
1 stop8h 10m
Southwest
Deal found 4/8![Southwest logo]()
$365
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:05 am
SAT
- DSM
1 stop7h 15m
Southwest
Sat 5/305:35 am
DSM
- SAT
2 stops9h 15m
Southwest
Deal found 4/8![Southwest logo]()
$391
One-way flights from San Antonio to Des MoinesSearch for one-way flight options from San Antonio to Des Moines. Find affordable one-way fares based on user searches. Data last updated April 9, 2026.
Search for one-way flight options from San Antonio to Des Moines. Find affordable one-way fares based on user searches. Data last updated April 9, 2026.
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:30 am
SAT
- DSM
1 stop7h 37m
Delta
Deal found 4/5![Delta logo]()
$204
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/114:13 pm
SAT
- DSM
2 stops7h 42m
United Airlines
Deal found 4/5![United Airlines logo]()
$209
This deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/224:45 pm
SAT
- DSM
1 stop6h 57m
United Airlines
Deal found 4/6![United Airlines logo]()
$284
Find flight deals from San Antonio to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from San Antonio (SAT) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $363 (Kiwi.com) |
One-way from | $204 (Delta) |
Popular in | December |
Cheapest in | June |
Average price | $370 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Antonio to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 9, 2026.
Use the filters below to find and compare flights from San Antonio to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
San AntonioDes Moines
SAT - DSM
SATDSM
San Antonio
Sat 5/23
4:35 pm-11:44 pm
1 stop7h 09m
Des Moines
Sat 5/30
5:50 am-12:43 pm
1 stop6h 53m
$365
San AntonioDes Moines
SAT - DSM
SATDSM
San Antonio
Thu 5/21
6:15 am-1:10 pm
1 stop6h 55m
Des Moines
Thu 5/28
4:20 pm-11:00 pm
2 stops6h 40m
$370
Quickest round-trip
San AntonioDes Moines
SAT - DSM
SATDSM
San Antonio
Sun 5/17
5:25 am-11:08 am
1 stop5h 43m
Des Moines
Thu 5/21
6:41 pm-12:44 am
1 stop6h 03m
$386
San AntonioDes Moines
SAT - DSM
SATDSM
San Antonio
Sat 5/23
6:05 am-1:20 pm
1 stop7h 15m
Des Moines
Sat 5/30
5:35 am-2:50 pm
2 stops9h 15m
$391
San AntonioDes Moines
SAT - DSM
SATDSM
San Antonio
Sun 5/17
7:54 pm-1:31 pm
1 stop17h 37m
Des Moines
Thu 5/21
8:00 am-8:14 pm
2 stops36h 14m
$398
San AntonioDes Moines
SAT - DSM
SATDSM
San Antonio
Thu 7/9
6:05 am-2:04 pm
1 stop7h 59m
Des Moines
Mon 7/13
2:48 pm-10:19 pm
1 stop7h 31m
$407
San AntonioDes Moines
SAT - DSM
SATDSM
San Antonio
Mon 7/13
2:21 pm-10:29 pm
1 stop8h 08m
Des Moines
Thu 7/16
6:38 pm-12:24 am
1 stop5h 46m
$407
San AntonioDes Moines
SAT - DSM
SATDSM
San Antonio
Tue 5/5
1:11 pm-8:16 pm
1 stop7h 05m
Des Moines
Wed 5/6
9:06 am-4:57 pm
1 stop7h 51m
$415
San AntonioDes Moines
SAT - DSM
SATDSM
San Antonio
Sat 5/2
4:39 pm-11:44 pm
1 stop7h 05m
Des Moines
Tue 5/5
5:30 am-12:56 pm
1 stop7h 26m
$426
Cheapest one-way
San AntonioDes Moines
SAT - DSM
SATDSM
San Antonio
Fri 9/11
6:30 am-2:07 pm
1 stop7h 37m
$204
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from San Antonio to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Antonio to Des Moines in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on San Antonio-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Antonio-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Antonio-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Antonio-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Antonio-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Antonio to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from San Antonio with our price prediction graph.
SAT-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Antonio to Des Moines
What is the cheapest month to book a flight from San Antonio to Des Moines?
Currently, January is the cheapest month in which you can book a flight from San Antonio to Des Moines (average of $66). Flying from San Antonio to Des Moines in December is currently the most expensive (average of $171). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from San Antonio to Des Moines?
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated April 9, 2026.
See what other customers who have flown with American Airlines from San Antonio to Des Moines have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
7.9
Food
6.4
Overall
7.1
Entertainment
6.9
Boarding
7.5
Comfort
7.2
Reviews
1 / 20
6.0
Goodsheila,Mar 2025
DFW - MSP
Crew
7.9
Food
6.4
Overall
7.1
Entertainment
6.9
Boarding
7.5
Comfort
7.2
Reviews
1 / 20
6.0
Goodsheila,Mar 2025
DFW - MSP
Related info for your journey
Find useful and relevant information for your journey from San Antonio to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Johnston
Ames
Clive
Ankeny
Boone
West Des Moines
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Des Moines flight routes
Flights by cabin class
Other flight options
Other flights from San Antonio
Popular flights
Alternative routes for San Antonio to Des Moines
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Des Moines by adding a car rental and/or hotel reservation to your travel itinerary.
Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 9, 2026.
Search flights from San Antonio to Des Moines by cabin class
Find flights from San Antonio to Des Moines, based on your preferred cabin class, be it economy, premium economy, business, or first class.
San Antonio and Des Moines flights
Browse other San Antonio and Des Moines flight options. Last updated on April 9, 2026.
Other flights from San Antonio
Browse through other flights departing from San Antonio. Flights are based on user searches made on Cheapflights and were last updated on April 9, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from San Antonio to Des Moines
Discover the top airline that operate flights from San Antonio to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$276 | Average$406 | FlexibilityNo cancel fee | On-time71% |