$159+ Cheap flights from Des Moines to San Antonio (DSM - SAT)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/29. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAT
Jul 26 — Aug 21
Round-trip
1 adult, Economy
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Cheapest flights from Des Moines to San AntonioExplore the most affordable flight options available from Des Moines to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 26, 2026.
Explore the most affordable flight options available from Des Moines to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 26, 2026.
This CheapOair deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/112:51 pm
DSM
- SAT
1 stop19h 21m
Frontier
Sun 9/137:49 pm
SAT
- DSM
1 stop18h 07m
Frontier
Deal found 6/24![Frontier logo]()
$278
This American Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/174:14 pm
DSM
- SAT
1 stop6h 36m
American Airlines
Thu 9/246:48 pm
SAT
- DSM
1 stop5h 16m
American Airlines
Deal found 6/26![American Airlines logo]()
$311
This Southwest deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/103:50 pm
DSM
- SAT
1 stop7h 25m
Southwest
Mon 8/172:15 pm
SAT
- DSM
1 stop7h 55m
Southwest
Deal found 6/26![Southwest logo]()
$312
This American Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:42 am
DSM
- SAT
1 stop7h 19m
American Airlines
Wed 11/1812:55 pm
SAT
- DSM
1 stop3h 46m
American Airlines
Deal found 6/23![American Airlines logo]()
$317
This American Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/84:13 pm
DSM
- SAT
1 stop4h 44m
American Airlines
Sat 8/155:00 am
SAT
- DSM
1 stop4h 01m
American Airlines
Deal found 6/24![American Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/151:21 pm
DSM
- SAT
2 stops7h 55m
United Airlines
Sat 8/226:30 am
SAT
- DSM
1 stop5h 50m
United Airlines
Deal found 6/22![United Airlines logo]()
$322
This Southwest deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/1512:10 pm
DSM
- SAT
2 stops6h 30m
Southwest
Sat 8/226:20 am
SAT
- DSM
2 stops7h 50m
Southwest
Deal found 6/22![Southwest logo]()
$327
This American Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/247:40 pm
DSM
- SAT
1 stop4h 15m
American Airlines
Sat 9/266:48 pm
SAT
- DSM
1 stop5h 16m
American Airlines
Deal found 6/24![American Airlines logo]()
$329
This United Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:00 am
DSM
- SAT
1 stop4h 43m
United Airlines
Sat 9/265:30 am
SAT
- DSM
2 stops8h 45m
United Airlines
Deal found 6/24![United Airlines logo]()
$334
This United Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/213:24 pm
DSM
- SAT
2 stops7h 18m
United Airlines
Tue 7/284:18 pm
SAT
- DSM
1 stop6h 17m
United Airlines
Deal found 6/23![United Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/67:35 pm
DSM
- SAT
1 stop4h 24m
American Airlines
Thu 8/136:20 pm
SAT
- DSM
1 stop5h 10m
American Airlines
Deal found 6/22![American Airlines logo]()
$341
This Southwest deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/272:25 pm
DSM
- SAT
2 stops7h 30m
Southwest
Mon 8/312:20 pm
SAT
- DSM
1 stop6h 55m
Southwest
Deal found 6/22![Southwest logo]()
$346
Best flights from Des Moines to San AntonioDiscover carefully curated flight deals from Des Moines to San Antonio that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 26, 2026.
Discover carefully curated flight deals from Des Moines to San Antonio that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 26, 2026.
This United Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:00 am
DSM
- SAT
1 stop6h 29m
United Airlines
Wed 8/55:32 pm
SAT
- DSM
1 stop5h 24m
United Airlines
Deal found 6/21![United Airlines logo]()
$317
This Southwest deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/103:50 pm
DSM
- SAT
1 stop7h 25m
Southwest
Mon 8/171:00 pm
SAT
- DSM
2 stops9h 10m
Southwest
Deal found 6/26![Southwest logo]()
$317
This United Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/223:24 pm
DSM
- SAT
1 stop7h 33m
United Airlines
Wed 7/295:32 pm
SAT
- DSM
1 stop5h 24m
United Airlines
Deal found 6/24![United Airlines logo]()
$317
This Southwest deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/1512:10 pm
DSM
- SAT
2 stops6h 30m
Southwest
Sat 8/226:20 am
SAT
- DSM
2 stops7h 50m
Southwest
Deal found 6/22![Southwest logo]()
$327
This Southwest deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/273:50 pm
DSM
- SAT
2 stops7h 05m
Southwest
Mon 8/315:35 am
SAT
- DSM
2 stops8h 10m
Southwest
Deal found 6/22![Southwest logo]()
$351
This Southwest deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:10 am
DSM
- SAT
1 stop6h 40m
Southwest
Wed 8/53:15 pm
SAT
- DSM
2 stops6h 40m
Southwest
Deal found 6/21![Southwest logo]()
$353
This Southwest deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/62:25 pm
DSM
- SAT
1 stop4h 45m
Southwest
Thu 8/132:15 pm
SAT
- DSM
1 stop7h 55m
Southwest
Deal found 6/22![Southwest logo]()
$370
This Southwest deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/155:30 am
DSM
- SAT
1 stop11h 00m
Southwest
Sun 8/233:20 pm
SAT
- DSM
2 stops7h 30m
Southwest
Deal found 6/25![Southwest logo]()
$373
This Southwest deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/223:45 pm
DSM
- SAT
1 stop8h 00m
Southwest
Wed 7/298:20 am
SAT
- DSM
2 stops6h 45m
Southwest
Deal found 6/24![Southwest logo]()
$377
This Southwest deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/133:50 pm
DSM
- SAT
2 stops7h 05m
Southwest
Sun 8/163:50 pm
SAT
- DSM
2 stops7h 00m
Southwest
Deal found 6/24![Southwest logo]()
$384
Last-minute flights from Des Moines to San AntonioDiscover last-minute flight deals from Des Moines to San Antonio. Data last updated June 26, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to San Antonio. Data last updated June 26, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/167:13 pm
DSM
- SAT
1 stop4h 45m
American Airlines
Sat 7/256:24 am
SAT
- DSM
1 stop6h 39m
American Airlines
Deal found 6/23![American Airlines logo]()
$372
This Southwest deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/164:40 pm
DSM
- SAT
1 stop7h 30m
Southwest
Tue 7/2812:55 pm
SAT
- DSM
2 stops8h 50m
Southwest
Deal found 6/23![Southwest logo]()
$422
This United Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/213:24 pm
DSM
- SAT
2 stops7h 18m
United Airlines
Tue 7/284:18 pm
SAT
- DSM
1 stop6h 17m
United Airlines
Deal found 6/23![United Airlines logo]()
$339
This Southwest deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:25 am
DSM
- SAT
2 stops8h 35m
Southwest
Tue 7/282:40 pm
SAT
- DSM
2 stops8h 10m
Southwest
Deal found 6/23![Southwest logo]()
$403
This Delta deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/222:45 pm
DSM
- SAT
1 stop6h 41m
Delta
Tue 7/286:40 am
SAT
- DSM
1 stop6h 54m
Delta
Deal found 6/23![Delta logo]()
$317
This Southwest deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/223:45 pm
DSM
- SAT
1 stop8h 00m
Southwest
Wed 7/298:20 am
SAT
- DSM
2 stops6h 45m
Southwest
Deal found 6/24![Southwest logo]()
$377
This United Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/225:17 pm
DSM
- SAT
1 stop6h 38m
United Airlines
Wed 7/291:25 pm
SAT
- DSM
1 stop7h 57m
United Airlines
Deal found 6/23![United Airlines logo]()
$397
This Delta deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/222:45 pm
DSM
- SAT
1 stop6h 41m
Delta
Thu 7/304:15 pm
SAT
- DSM
1 stop6h 14m
Delta
Deal found 6/23![Delta logo]()
$406
This Delta deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/232:45 pm
DSM
- SAT
1 stop6h 41m
Delta
Mon 7/274:15 pm
SAT
- DSM
1 stop6h 14m
Delta
Deal found 6/23![Delta logo]()
$407
This Southwest deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/234:40 pm
DSM
- SAT
1 stop7h 30m
Southwest
Wed 7/2912:55 pm
SAT
- DSM
2 stops8h 50m
Southwest
Deal found 6/23![Southwest logo]()
$412
This American Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/267:13 pm
DSM
- SAT
1 stop3h 51m
American Airlines
Tue 7/285:01 am
SAT
- DSM
1 stop4h 10m
American Airlines
Deal found 6/23![American Airlines logo]()
$362
This American Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/284:48 pm
DSM
- SAT
1 stop6h 16m
American Airlines
Fri 7/315:47 pm
SAT
- DSM
1 stop6h 22m
American Airlines
Deal found 6/22![American Airlines logo]()
$367
One-way flights from Des Moines to San AntonioSearch for one-way flight options from Des Moines to San Antonio. Find affordable one-way fares based on user searches. Data last updated June 26, 2026.
Search for one-way flight options from Des Moines to San Antonio. Find affordable one-way fares based on user searches. Data last updated June 26, 2026.
This American Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/296:33 pm
DSM
- SAT
1 stop5h 37m
American Airlines
Deal found 6/25![American Airlines logo]()
$159
This United Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/111:21 pm
DSM
- SAT
2 stops7h 55m
United Airlines
Deal found 6/25![United Airlines logo]()
$164
This Kiwi.com deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/102:19 pm
DSM
- SAT
1 stop28h 35m
Frontier
Deal found 6/25![Frontier logo]()
$166
This Delta deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/132:45 pm
DSM
- SAT
1 stop6h 44m
Delta
Deal found 6/25![Delta logo]()
$171
This Kiwi.com deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/242:19 pm
DSM
- SAT
1 stop28h 25m
Frontier
Deal found 6/25![Frontier logo]()
$176
This Kiwi.com deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/99:33 am
DSM
- SAT
1 stop23h 23m
Multiple Airlines
Deal found 6/25![Multiple Airlines logo]()
$177
This Southwest deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/293:45 pm
DSM
- SAT
2 stops6h 40m
Southwest
Deal found 6/25![Southwest logo]()
$195
This American Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/84:13 pm
DSM
- SAT
1 stop6h 41m
American Airlines
Deal found 6/25![American Airlines logo]()
$199
This Kiwi.com deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:12 pm
DSM
- SAT
3 stops46h 29m
Multiple Airlines
Deal found 6/25![Multiple Airlines logo]()
$203
This American Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/244:48 pm
DSM
- SAT
1 stop7h 10m
American Airlines
Deal found 6/24![American Airlines logo]()
$204
Find flight deals from Des Moines to San Antonio
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to San Antonio (SAT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 26, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $278 (CheapOair) |
One-way from | $159 (American Airlines) |
Popular in | June |
Cheapest in | August |
Average price | $760 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 26, 2026.
Use the filters below to find and compare flights from Des Moines to San Antonio that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Wed 8/5
6:00 am-12:29 pm
1 stop6h 29m
San Antonio
Wed 8/5
5:32 pm-10:56 pm
1 stop5h 24m
$317
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Mon 8/10
3:50 pm-11:15 pm
1 stop7h 25m
San Antonio
Mon 8/17
1:00 pm-10:10 pm
2 stops9h 10m
$317
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Wed 7/22
3:24 pm-10:57 pm
1 stop7h 33m
San Antonio
Wed 7/29
5:32 pm-10:56 pm
1 stop5h 24m
$317
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Sat 8/15
12:10 pm-6:40 pm
2 stops6h 30m
San Antonio
Sat 8/22
6:20 am-2:10 pm
2 stops7h 50m
$327
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Thu 8/27
3:50 pm-10:55 pm
2 stops7h 05m
San Antonio
Mon 8/31
5:35 am-1:45 pm
2 stops8h 10m
$351
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Wed 8/5
6:10 am-12:50 pm
1 stop6h 40m
San Antonio
Wed 8/5
3:15 pm-9:55 pm
2 stops6h 40m
$353
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Thu 8/6
2:25 pm-7:10 pm
1 stop4h 45m
San Antonio
Thu 8/13
2:15 pm-10:10 pm
1 stop7h 55m
$370
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Sat 8/15
5:30 am-4:30 pm
1 stop11h 00m
San Antonio
Sun 8/23
3:20 pm-10:50 pm
2 stops7h 30m
$373
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Wed 7/22
3:45 pm-11:45 pm
1 stop8h 00m
San Antonio
Wed 7/29
8:20 am-3:05 pm
2 stops6h 45m
$377
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Thu 8/13
3:50 pm-10:55 pm
2 stops7h 05m
San Antonio
Sun 8/16
3:50 pm-10:50 pm
2 stops7h 00m
$384
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Des Moines to San Antonio
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Antonio in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-San Antonio flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Antonio flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Antonio flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-San Antonio flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Antonio flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to San Antonio
Have a flexible travel schedule? Discover the best time to fly to San Antonio from Des Moines with our price prediction graph.
DSM-SAT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to San Antonio
How far ahead should I book a flight from Des Moines to San Antonio?
The price you pay for your flight from Des Moines to San Antonio may vary depending on when you book. For the best chance of a lower fare, look to book 30 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Des Moines to San Antonio?
Currently, August is the cheapest month in which you can book a flight from Des Moines to San Antonio (average of $321). Flying from Des Moines to San Antonio in June is currently the most expensive (average of $760). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing San Antonio
Get insights into the airlines that provide service to San Antonio. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Antonio. Reviews last updated June 26, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from Des Moines to San Antonio. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
7.9
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreMike,Aug 2025
OKC - AUS
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
7.9
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreMike,Aug 2025
OKC - AUS
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
7.9
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreMike,Aug 2025
OKC - AUS
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
7.9
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreMike,Aug 2025
OKC - AUS
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
7.9
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreMike,Aug 2025
OKC - AUS
Related info for your journey
Find useful and relevant information for your journey from Des Moines to San Antonio. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Antonio?
Book flights to San Antonio if you plan to visit one of these locationsNew Braunfels
Kerrville
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Des Moines and San Antonio flights
Browse other Des Moines and San Antonio flight options. Last updated on June 26, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on June 26, 2026.
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Check out other popular destinations found by fellow travelers in 2026
Other flights to San Antonio
Explore flights to San Antonio departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 26, 2026.
Top 4 airlines flying from Des Moines to San Antonio
Discover the top 4 airlines that operate flights from Des Moines to San Antonio. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$213 | Average$387 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$262 | Average$387 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$312 | Average$435 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$359 | Average$421 | FlexibilityNo cancel fee | On-time63% |