$116+ Cheap flights from Des Moines to San Antonio (DSM - SAT)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/24. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAT
Sep 5 — Sep 121
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to San Antonio with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to San Antonio
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Best
Last-minute
One-way
Cheapest flights from Des Moines to San AntonioExplore the most affordable flight options available from Des Moines to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 6, 2026.
Explore the most affordable flight options available from Des Moines to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 6, 2026.
This Frontier deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/312:19 pm -
1 stop5h 12m
Wed 9/98:20 pm -
1 stop14h 24m
Deal found 8/6![Frontier logo]()
$233
This CheapOair deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1711:29 am -
1 stop7h 56m
Thu 9/248:20 pm -
1 stop23h 13m
Deal found 8/4![Frontier logo]()
$242
This CheapOair deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/111:29 am -
1 stop7h 56m
Sun 10/48:20 pm -
1 stop23h 13m
Deal found 8/4![Frontier logo]()
$257
This CheapOair deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/411:29 am -
1 stop7h 56m
Thu 10/83:10 pm -
1 stop22h 08m
Deal found 8/3![Frontier logo]()
$264
This CheapOair deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/92:51 pm -
1 stop19h 21m
Thu 11/127:56 pm -
1 stop18h 00m
Deal found 8/4![Frontier logo]()
$276
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1711:29 am -
1 stop7h 56m
Wed 9/238:20 pm -
1 stop14h 24m
Deal found 8/1![Frontier logo]()
$294
This CheapOair deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:19 pm -
1 stop5h 12m
Sun 8/238:26 pm -
1 stop17h 08m
Deal found 8/3![Frontier logo]()
$310
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1011:29 am -
2 stops21h 41m
Sat 9/128:20 pm -
1 stop14h 24m
Deal found 8/3![Frontier logo]()
$312
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:20 am -
2 stops37h 05m
Wed 9/238:20 pm -
1 stop14h 24m
Deal found 8/1![Multiple Airlines logo]()
$324
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/44:13 pm -
1 stop4h 44m
Sun 9/66:52 pm -
1 stop5h 28m
Deal found 8/5![American Airlines logo]()
$326
This United Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/93:02 pm -
1 stop6h 14m
Thu 9/104:12 pm -
1 stop6h 18m
Deal found 8/3![United Airlines logo]()
$327
Best flights from Des Moines to San AntonioDiscover carefully curated flight deals from Des Moines to San Antonio that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 6, 2026.
Discover carefully curated flight deals from Des Moines to San Antonio that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 6, 2026.
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/12:46 pm -
1 stop6h 36m
Mon 10/56:35 am -
1 stop7h 14m
Deal found 8/4![Delta logo]()
$351
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1912:10 pm -
2 stops8h 15m
Sat 9/261:10 pm -
1 stop7h 40m
Deal found 8/5![Southwest logo]()
$356
This United Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/48:00 am -
1 stop8h 31m
Thu 9/105:59 pm -
1 stop4h 31m
Deal found 8/1![United Airlines logo]()
$356
This Delta deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:54 pm -
1 stop5h 14m
Wed 9/236:00 am -
1 stop8h 06m
Deal found 8/2![Delta logo]()
$351
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/312:25 pm -
2 stops9h 00m
Wed 9/97:00 am -
1 stop6h 55m
Deal found 8/6![Southwest logo]()
$356
This United Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/43:20 pm -
2 stops7h 19m
Mon 9/76:30 am -
1 stop5h 50m
Deal found 8/5![United Airlines logo]()
$373
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:10 am -
2 stops6h 40m
Wed 9/2311:00 am -
1 stop6h 45m
Deal found 8/2![Southwest logo]()
$356
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:10 am -
2 stops8h 45m
Mon 10/512:20 pm -
2 stops9h 35m
Deal found 8/4![Southwest logo]()
$361
This Southwest deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/43:50 pm -
2 stops7h 10m
Thu 9/106:25 am -
1 stop7h 20m
Deal found 8/1![Southwest logo]()
$361
This Southwest deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/182:25 pm -
2 stops9h 05m
Tue 9/227:00 am -
1 stop6h 55m
Deal found 8/1![Southwest logo]()
$373
Last-minute flights from Des Moines to San AntonioDiscover last-minute flight deals from Des Moines to San Antonio. Data last updated August 6, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to San Antonio. Data last updated August 6, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:19 pm -
1 stop5h 12m
Sun 8/238:26 pm -
1 stop17h 08m
Deal found 8/3![Frontier logo]()
$310
This Frontier deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/312:19 pm -
1 stop5h 12m
Wed 9/98:20 pm -
1 stop14h 24m
Deal found 8/6![Frontier logo]()
$233
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/44:13 pm -
1 stop4h 44m
Sun 9/66:52 pm -
1 stop5h 28m
Deal found 8/5![American Airlines logo]()
$326
This United Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/93:02 pm -
1 stop6h 14m
Thu 9/104:12 pm -
1 stop6h 18m
Deal found 8/3![United Airlines logo]()
$327
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:10 am -
2 stops6h 40m
Thu 9/102:20 pm -
1 stop7h 00m
Deal found 8/3![Southwest logo]()
$332
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1011:29 am -
2 stops21h 41m
Sat 9/128:20 pm -
1 stop14h 24m
Deal found 8/3![Frontier logo]()
$312
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/102:25 pm -
2 stops7h 35m
Fri 9/112:15 pm -
1 stop8h 00m
Deal found 8/3![Southwest logo]()
$331
This CheapOair deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1711:29 am -
1 stop7h 56m
Thu 9/248:20 pm -
1 stop23h 13m
Deal found 8/4![Frontier logo]()
$242
This CheapOair deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/188:30 pm -
1 stop22h 55m
Sun 9/278:20 pm -
1 stop23h 13m
Deal found 8/6![Frontier logo]()
$264
One-way flights from Des Moines to San AntonioSearch for one-way flight options from Des Moines to San Antonio. Find affordable one-way fares based on user searches. Data last updated August 6, 2026.
Search for one-way flight options from Des Moines to San Antonio. Find affordable one-way fares based on user searches. Data last updated August 6, 2026.
This Priceline deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2411:29 am -
1 stop7h 56m
Deal found 8/3![Frontier logo]()
$116
This CheapOair deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/162:31 pm -
1 stop20h 50m
Deal found 8/4![Frontier logo]()
$134
This Priceline deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:19 pm -
1 stop5h 12m
Deal found 8/5![Frontier logo]()
$150
This United Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/65:21 pm -
1 stop6h 36m
Deal found 8/5![United Airlines logo]()
$163
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:54 pm -
1 stop5h 39m
Deal found 8/4![Delta logo]()
$176
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/54:30 pm -
2 stops8h 10m
Deal found 8/3![Southwest logo]()
$181
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/242:25 pm -
2 stops7h 35m
Deal found 8/4![Southwest logo]()
$198
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/61:58 pm -
3 stops53h 33m
Deal found 8/5![Multiple Airlines logo]()
$215
Find flight deals from Des Moines to San Antonio
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to San Antonio (SAT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 6, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $233 (Frontier) |
One-way from | $116 (Priceline) |
Popular in | June |
Cheapest in | November |
Average price | $391 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 6, 2026.
Use the filters below to find and compare flights from Des Moines to San Antonio that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSan Antonio
DSM Des Moines - SAT San Antonio
DSMSAT
Des Moines
Thu 10/1
2:46 pm-9:22 pm
1 stop6h 36m
San Antonio
Mon 10/5
6:35 am-1:49 pm
1 stop7h 14m
$351
Des MoinesSan Antonio
DSM Des Moines - SAT San Antonio
DSMSAT
Des Moines
Wed 9/16
6:54 pm-12:08 am
1 stop5h 14m
San Antonio
Wed 9/23
6:00 am-2:06 pm
1 stop8h 06m
$351
Des MoinesSan Antonio
DSM Des Moines - SAT San Antonio
DSMSAT
Des Moines
Sat 9/19
12:10 pm-8:25 pm
2 stops8h 15m
San Antonio
Sat 9/26
1:10 pm-8:50 pm
1 stop7h 40m
$356
Quickest round-trip
Des MoinesSan Antonio
DSM Des Moines - SAT San Antonio
DSMSAT
Des Moines
Fri 9/4
8:00 am-4:31 pm
1 stop8h 31m
San Antonio
Thu 9/10
5:59 pm-10:30 pm
1 stop4h 31m
$356
Des MoinesSan Antonio
DSM Des Moines - SAT San Antonio
DSMSAT
Des Moines
Mon 8/31
2:25 pm-11:25 pm
2 stops9h 00m
San Antonio
Wed 9/9
7:00 am-1:55 pm
1 stop6h 55m
$356
Des MoinesSan Antonio
DSM Des Moines - SAT San Antonio
DSMSAT
Des Moines
Wed 9/16
6:10 am-12:50 pm
2 stops6h 40m
San Antonio
Wed 9/23
11:00 am-5:45 pm
1 stop6h 45m
$356
Des MoinesSan Antonio
DSM Des Moines - SAT San Antonio
DSMSAT
Des Moines
Thu 10/1
5:10 am-1:55 pm
2 stops8h 45m
San Antonio
Mon 10/5
12:20 pm-9:55 pm
2 stops9h 35m
$361
Des MoinesSan Antonio
DSM Des Moines - SAT San Antonio
DSMSAT
Des Moines
Fri 9/4
3:50 pm-11:00 pm
2 stops7h 10m
San Antonio
Thu 9/10
6:25 am-1:45 pm
1 stop7h 20m
$361
Des MoinesSan Antonio
DSM Des Moines - SAT San Antonio
DSMSAT
Des Moines
Fri 9/4
3:20 pm-10:39 pm
2 stops7h 19m
San Antonio
Mon 9/7
6:30 am-12:20 pm
1 stop5h 50m
$373
Des MoinesSan Antonio
DSM Des Moines - SAT San Antonio
DSMSAT
Des Moines
Fri 9/18
2:25 pm-11:30 pm
2 stops9h 05m
San Antonio
Tue 9/22
7:00 am-1:55 pm
1 stop6h 55m
$373
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from Des Moines to San Antonio
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Antonio in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-San Antonio flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Antonio flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Antonio flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-San Antonio flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Antonio flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to San Antonio
Have a flexible travel schedule? Discover the best time to fly to San Antonio from Des Moines with our price prediction graph.
DSM-SAT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to San Antonio
What is the cheapest month to book a flight from Des Moines to San Antonio?
Currently, November is the cheapest month in which you can book a flight from Des Moines to San Antonio (average of $379). Flying from Des Moines to San Antonio in June is currently the most expensive (average of $760). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to San Antonio?
Airfare is below average for this route at the moment.
Des Moines to San Antonio flights typically cost between $289 and $541 in August.The cheapest round-trip price found within the last 5 days was $233 on Frontier (Aug 31-Sep 9).
Reviews of airlines servicing San Antonio
Get insights into the airlines that provide service to San Antonio. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Antonio. Reviews last updated August 6, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from Des Moines to San Antonio. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Crew
8.6
Boarding
8.1
Comfort
8.0
Food
7.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreMike,Aug 2025
OKC - AUS
Entertainment
7.5
Crew
8.6
Boarding
8.1
Comfort
8.0
Food
7.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreMike,Aug 2025
OKC - AUS
Entertainment
7.5
Crew
8.6
Boarding
8.1
Comfort
8.0
Food
7.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreMike,Aug 2025
OKC - AUS
Entertainment
7.5
Crew
8.6
Boarding
8.1
Comfort
8.0
Food
7.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreMike,Aug 2025
OKC - AUS
Entertainment
7.5
Crew
8.6
Boarding
8.1
Comfort
8.0
Food
7.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreMike,Aug 2025
OKC - AUS
Related info for your journey
Find useful and relevant information for your journey from Des Moines to San Antonio. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Antonio?
Book flights to San Antonio if you plan to visit one of these locationsNew Braunfels
Kerrville
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Find flights from Des Moines to San Antonio, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and San Antonio flights
Browse other Des Moines and San Antonio flight options. Last updated on August 6, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on August 6, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Antonio
Explore flights to San Antonio departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 6, 2026.
Top 4 airlines flying from Des Moines to San Antonio
Discover the top 4 airlines that operate flights from Des Moines to San Antonio. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 6, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$213 | Average$387 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$293 | Average$412 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$312 | Average$446 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$359 | Average$421 | FlexibilityNo cancel fee | On-time63% |