$336+ Cheap flights from Des Moines to Amarillo (DSM - AMA)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/13. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — AMA
Oct 11 — Oct 181
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Amarillo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Amarillo
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Cheapest flights from Des Moines to AmarilloExplore the most affordable flight options available from Des Moines to Amarillo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2026.
Explore the most affordable flight options available from Des Moines to Amarillo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2026.
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/133:31 pm -
1 stop5h 58m
Mon 11/167:04 pm -
1 stop4h 01m
Deal found 9/10![American Airlines logo]()
$336
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/131:50 pm -
2 stops9h 45m
Mon 11/163:50 pm -
2 stops6h 10m
Deal found 9/10![Southwest logo]()
$343
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:42 pm -
1 stop4h 17m
Sun 11/15:14 pm -
1 stop5h 51m
Deal found 9/8![American Airlines logo]()
$353
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/175:12 pm -
1 stop4h 29m
Wed 11/187:40 am -
1 stop4h 51m
Deal found 9/10![United Airlines logo]()
$389
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:20 am -
2 stops6h 50m
Sun 11/111:05 am -
2 stops11h 55m
Deal found 9/8![Southwest logo]()
$390
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:00 am -
2 stops12h 50m
Sun 12/611:05 am -
2 stops10h 55m
Deal found 9/8![Southwest logo]()
$403
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:22 pm -
1 stop4h 22m
Tue 9/294:20 pm -
1 stop6h 52m
Deal found 9/10![American Airlines logo]()
$477
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/253:50 pm -
2 stops6h 20m
Tue 9/2911:55 am -
2 stops10h 05m
Deal found 9/10![Southwest logo]()
$487
Best flights from Des Moines to AmarilloDiscover carefully curated flight deals from Des Moines to Amarillo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 11, 2026.
Discover carefully curated flight deals from Des Moines to Amarillo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 11, 2026.
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/131:50 pm -
2 stops9h 45m
Mon 11/163:50 pm -
2 stops6h 10m
Deal found 9/10![Southwest logo]()
$343
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/175:12 pm -
1 stop4h 29m
Wed 11/187:40 am -
1 stop4h 51m
Deal found 9/10![United Airlines logo]()
$389
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/59:45 am -
1 stop4h 43m
Sun 12/62:58 pm -
2 stops9h 28m
Deal found 9/8![American Airlines logo]()
$396
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:42 pm -
1 stop4h 17m
Sun 11/12:58 pm -
2 stops9h 28m
Deal found 9/8![American Airlines logo]()
$396
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:00 am -
2 stops12h 50m
Sun 12/611:05 am -
2 stops10h 55m
Deal found 9/8![Southwest logo]()
$403
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/133:31 pm -
1 stop5h 58m
Mon 11/162:58 pm -
2 stops9h 28m
Deal found 9/10![American Airlines logo]()
$422
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/253:50 pm -
2 stops6h 20m
Tue 9/2911:55 am -
2 stops10h 05m
Deal found 9/10![Southwest logo]()
$487
Last-minute flights from Des Moines to AmarilloDiscover last-minute flight deals from Des Moines to Amarillo. Data last updated September 11, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Amarillo. Data last updated September 11, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/169:51 am -
1 stop4h 36m
Thu 9/1710:20 am -
1 stop4h 50m
Deal found 9/8![American Airlines logo]()
$667
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/167:15 am -
2 stops7h 40m
Thu 9/171:00 pm -
2 stops9h 15m
Deal found 9/8![Southwest logo]()
$677
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:22 pm -
1 stop4h 22m
Tue 9/294:20 pm -
1 stop6h 52m
Deal found 9/10![American Airlines logo]()
$477
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/253:50 pm -
2 stops6h 20m
Tue 9/2911:55 am -
2 stops10h 05m
Deal found 9/10![Southwest logo]()
$487
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:42 pm -
1 stop4h 17m
Sun 11/15:14 pm -
1 stop5h 51m
Deal found 9/8![American Airlines logo]()
$353
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:20 am -
2 stops6h 50m
Sun 11/111:05 am -
2 stops11h 55m
Deal found 9/8![Southwest logo]()
$390
Find flight deals from Des Moines to Amarillo
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Amarillo (AMA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $336 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Amarillo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 11, 2026.
Use the filters below to find and compare flights from Des Moines to Amarillo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesAmarillo
DSM Des Moines - AMA Amarillo
DSMAMA
Des Moines
Fri 11/13
1:50 pm-11:35 pm
2 stops9h 45m
Amarillo
Mon 11/16
3:50 pm-10:00 pm
2 stops6h 10m
$343
Quickest round-trip
Des MoinesAmarillo
DSM Des Moines - AMA Amarillo
DSMAMA
Des Moines
Tue 11/17
5:12 pm-9:41 pm
1 stop4h 29m
Amarillo
Wed 11/18
7:40 am-12:31 pm
1 stop4h 51m
$389
Des MoinesAmarillo
DSM Des Moines - AMA Amarillo
DSMAMA
Des Moines
Sat 12/5
9:45 am-2:28 pm
1 stop4h 43m
Amarillo
Sun 12/6
2:58 pm-12:26 am
2 stops9h 28m
$396
Des MoinesAmarillo
DSM Des Moines - AMA Amarillo
DSMAMA
Des Moines
Thu 10/29
7:42 pm-11:59 pm
1 stop4h 17m
Amarillo
Sun 11/1
2:58 pm-12:26 am
2 stops9h 28m
$396
Des MoinesAmarillo
DSM Des Moines - AMA Amarillo
DSMAMA
Des Moines
Sat 12/5
7:00 am-7:50 pm
2 stops12h 50m
Amarillo
Sun 12/6
11:05 am-10:00 pm
2 stops10h 55m
$403
Des MoinesAmarillo
DSM Des Moines - AMA Amarillo
DSMAMA
Des Moines
Fri 11/13
3:31 pm-9:29 pm
1 stop5h 58m
Amarillo
Mon 11/16
2:58 pm-12:26 am
2 stops9h 28m
$422
Des MoinesAmarillo
DSM Des Moines - AMA Amarillo
DSMAMA
Des Moines
Fri 9/25
3:50 pm-10:10 pm
2 stops6h 20m
Amarillo
Tue 9/29
11:55 am-10:00 pm
2 stops10h 05m
$487
Sorted by cheapest first
Compare providers for flights from Des Moines to Amarillo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Amarillo in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Amarillo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Amarillo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Amarillo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Amarillo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Amarillo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Amarillo
Have a flexible travel schedule? Discover the best time to fly to Amarillo from Des Moines with our price prediction graph.
DSM-AMA
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Amarillo
Get insights into the airlines that provide service to Amarillo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Amarillo. Reviews last updated September 11, 2026.
See what other customers who have flown with American Airlines from Des Moines to Amarillo have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
6.8
Food
6.4
Overall
7.1
Crew
7.9
Boarding
7.5
Comfort
7.2
Reviews
1 / 20
8.0
ExcellentMonica,Nov 2025
JAC - DFW
Entertainment
6.8
Food
6.4
Overall
7.1
Crew
7.9
Boarding
7.5
Comfort
7.2
Reviews
1 / 20
8.0
ExcellentMonica,Nov 2025
JAC - DFW
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Amarillo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Amarillo?
Book flights to Amarillo if you plan to visit one of these locationsDalhart
Dumas
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Des Moines and Amarillo flights
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Top airline flying from Des Moines to Amarillo
Discover the top airline that operate flights from Des Moines to Amarillo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$296 | Average$639 | FlexibilityNo cancel fee | On-time71% |