$249+ Cheap flights from Amarillo to Des Moines (AMA - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/11. Fares are subject to change and may not be available on all flights or dates of travel.
AMA — DSM
Oct 29 — Nov 51
Round-trip
1 adult, Economy
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Find cheap flights from Amarillo to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Amarillo to Des Moines
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Cheapest flights from Amarillo to Des MoinesExplore the most affordable flight options available from Amarillo to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 29, 2026.
Explore the most affordable flight options available from Amarillo to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 29, 2026.
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2412:40 pm -
1 stop6h 18m
Fri 1/17:43 pm -
1 stop4h 16m
Deal found 9/28![American Airlines logo]()
$329
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/243:50 pm -
2 stops6h 10m
Fri 1/16:00 am -
2 stops10h 25m
Deal found 9/28![Southwest logo]()
$383
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2211:30 am -
2 stops11h 00m
Fri 1/16:00 am -
2 stops10h 25m
Deal found 9/28![Southwest logo]()
$395
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2212:40 pm -
1 stop6h 18m
Fri 1/17:43 pm -
1 stop4h 16m
Deal found 9/28![American Airlines logo]()
$396
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/117:06 pm -
1 stop4h 01m
Thu 10/157:42 pm -
1 stop4h 17m
Deal found 9/25![American Airlines logo]()
$497
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/111:55 pm -
2 stops7h 40m
Thu 10/156:20 am -
2 stops6h 50m
Deal found 9/25![Southwest logo]()
$507
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/255:30 am -
2 stops8h 05m
Sun 11/11:50 pm -
2 stops9h 45m
Deal found 9/25![Southwest logo]()
$528
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/2512:45 pm -
1 stop6h 15m
Sun 11/17:37 pm -
1 stop4h 17m
Deal found 9/25![American Airlines logo]()
$542
Best flights from Amarillo to Des MoinesDiscover carefully curated flight deals from Amarillo to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 29, 2026.
Discover carefully curated flight deals from Amarillo to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 29, 2026.
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2412:40 pm -
1 stop6h 18m
Fri 1/17:43 pm -
1 stop4h 16m
Deal found 9/28![American Airlines logo]()
$329
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/243:50 pm -
2 stops6h 10m
Fri 1/16:00 am -
2 stops10h 25m
Deal found 9/28![Southwest logo]()
$383
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/265:40 pm -
1 stop5h 59m
Sun 3/285:03 pm -
1 stop4h 38m
Deal found 9/25![United Airlines logo]()
$439
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/117:06 pm -
1 stop4h 01m
Thu 10/157:42 pm -
1 stop4h 17m
Deal found 9/25![American Airlines logo]()
$497
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/111:55 pm -
2 stops7h 40m
Thu 10/156:20 am -
2 stops6h 50m
Deal found 9/25![Southwest logo]()
$507
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/265:20 am -
2 stops10h 20m
Sun 3/285:15 am -
2 stops12h 05m
Deal found 9/25![Southwest logo]()
$523
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/255:30 am -
2 stops8h 05m
Sun 11/11:50 pm -
2 stops9h 45m
Deal found 9/25![Southwest logo]()
$528
Last-minute flights from Amarillo to Des MoinesDiscover last-minute flight deals from Amarillo to Des Moines. Data last updated September 29, 2026 and is based on user searches.
Discover last-minute flight deals from Amarillo to Des Moines. Data last updated September 29, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:00 am -
1 stop4h 17m
Sun 10/47:40 pm -
1 stop4h 08m
Deal found 9/28![American Airlines logo]()
$758
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/23:20 pm -
2 stops6h 50m
Sun 10/412:00 pm -
2 stops11h 55m
Deal found 9/28![Southwest logo]()
$847
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/117:06 pm -
1 stop4h 01m
Thu 10/157:42 pm -
1 stop4h 17m
Deal found 9/25![American Airlines logo]()
$497
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/111:55 pm -
2 stops7h 40m
Thu 10/156:20 am -
2 stops6h 50m
Deal found 9/25![Southwest logo]()
$507
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/255:30 am -
2 stops8h 05m
Sun 11/11:50 pm -
2 stops9h 45m
Deal found 9/25![Southwest logo]()
$528
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/2512:45 pm -
1 stop6h 15m
Sun 11/17:37 pm -
1 stop4h 17m
Deal found 9/25![American Airlines logo]()
$542
One-way flights from Amarillo to Des MoinesSearch for one-way flight options from Amarillo to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 29, 2026.
Search for one-way flight options from Amarillo to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 29, 2026.
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/117:06 pm -
1 stop4h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/25![American Airlines logo]()
$249
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/111:55 pm -
2 stops7h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/25![Southwest logo]()
$254
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/113:20 pm -
3 stops21h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/25![United Airlines logo]()
$644
Find flight deals from Amarillo to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Amarillo (AMA) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $329 (American Airlines) |
One-way from | $249 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Amarillo to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 29, 2026.
Use the filters below to find and compare flights from Amarillo to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
AmarilloDes Moines
AMA Amarillo - DSM Des Moines
AMADSM
Amarillo
Sun 10/11
7:06 pm-11:07 pm
1 stop4h 01m
Des Moines
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$249
AmarilloDes Moines
AMA Amarillo - DSM Des Moines
AMADSM
Amarillo
Sun 10/11
1:55 pm-9:35 pm
2 stops7h 40m
Des Moines
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$254
AmarilloDes Moines
AMA Amarillo - DSM Des Moines
AMADSM
Amarillo
Thu 12/24
12:40 pm-6:58 pm
1 stop6h 18m
Des Moines
Fri 1/1
7:43 pm-11:59 pm
1 stop4h 16m
$329
AmarilloDes Moines
AMA Amarillo - DSM Des Moines
AMADSM
Amarillo
Thu 12/24
3:50 pm-10:00 pm
2 stops6h 10m
Des Moines
Fri 1/1
6:00 am-4:25 pm
2 stops10h 25m
$383
AmarilloDes Moines
AMA Amarillo - DSM Des Moines
AMADSM
Amarillo
Fri 3/26
5:40 pm-11:39 pm
1 stop5h 59m
Des Moines
Sun 3/28
5:03 pm-9:41 pm
1 stop4h 38m
$439
AmarilloDes Moines
AMA Amarillo - DSM Des Moines
AMADSM
Amarillo
Sun 10/11
7:06 pm-11:07 pm
1 stop4h 01m
Des Moines
Thu 10/15
7:42 pm-11:59 pm
1 stop4h 17m
$497
AmarilloDes Moines
AMA Amarillo - DSM Des Moines
AMADSM
Amarillo
Sun 10/11
1:55 pm-9:35 pm
2 stops7h 40m
Des Moines
Thu 10/15
6:20 am-1:10 pm
2 stops6h 50m
$507
AmarilloDes Moines
AMA Amarillo - DSM Des Moines
AMADSM
Amarillo
Fri 3/26
5:20 am-3:40 pm
2 stops10h 20m
Des Moines
Sun 3/28
5:15 am-5:20 pm
2 stops12h 05m
$523
AmarilloDes Moines
AMA Amarillo - DSM Des Moines
AMADSM
Amarillo
Sun 10/25
5:30 am-1:35 pm
2 stops8h 05m
Des Moines
Sun 11/1
1:50 pm-11:35 pm
2 stops9h 45m
$528
AmarilloDes Moines
AMA Amarillo - DSM Des Moines
AMADSM
Amarillo
Sun 10/11
3:20 pm-12:31 pm
3 stops21h 11m
Des Moines
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$644
Sorted by cheapest first
Compare providers for flights from Amarillo to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Amarillo to Des Moines in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Amarillo-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Amarillo-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Amarillo-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Amarillo-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Amarillo-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Amarillo to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Amarillo with our price prediction graph.
AMA-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated September 29, 2026.
Get a feel of what it's like to fly with American Airlines from Amarillo to Des Moines by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.0
Crew
7.9
Comfort
7.2
Entertainment
6.8
Boarding
7.4
Food
6.4
Reviews
1 / 20
2.0
MediocreAnonymous,Apr 2026
DFW - BDL
Overall
7.0
Crew
7.9
Comfort
7.2
Entertainment
6.8
Boarding
7.4
Food
6.4
Reviews
1 / 20
2.0
MediocreAnonymous,Apr 2026
DFW - BDL
Related info for your journey
Find useful and relevant information for your journey from Amarillo to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
Ames
West Des Moines
Johnston
Boone
Norwalk
Ankeny
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Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 29, 2026.
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Amarillo and Des Moines flights
Browse other Amarillo and Des Moines flight options. Last updated on September 29, 2026.
Other flights from Amarillo
Browse through other flights departing from Amarillo. Flights are based on user searches made on Cheapflights and were last updated on September 29, 2026.
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Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Amarillo to Des Moines
Discover the top airline that operate flights from Amarillo to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$383 | Average$601 | FlexibilityNo cancel fee | On-time71% |