$178+ Cheap flights from Des Moines to McAllen (DSM - MFE)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/7. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MFE
Sep 18 — Sep 251
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Des Moines to McAllen with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to McAllen
Cheapest
Best
Last-minute
One-way
Cheapest flights from Des Moines to McAllenExplore the most affordable flight options available from Des Moines to McAllen. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 19, 2026.
Explore the most affordable flight options available from Des Moines to McAllen. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 19, 2026.
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/234:14 pm -
1 stop5h 30m
Wed 9/304:35 pm -
1 stop6h 37m
Deal found 8/16![American Airlines logo]()
$295
This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:41 am -
1 stop6h 28m
Wed 9/304:35 pm -
1 stop6h 37m
Deal found 8/15![American Airlines logo]()
$301
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:00 am -
2 stops10h 37m
Wed 9/305:20 am -
2 stops11h 28m
Deal found 8/17![Delta logo]()
$305
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:35 pm -
2 stops8h 24m
Sat 9/265:20 pm -
1 stop4h 56m
Deal found 8/16![United Airlines logo]()
$310
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:15 am -
1 stop7h 12m
Tue 9/297:00 am -
2 stops9h 20m
Deal found 8/16![United Airlines logo]()
$311
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/194:14 pm -
1 stop5h 30m
Tue 9/294:35 pm -
1 stop6h 37m
Deal found 8/16![American Airlines logo]()
$325
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:00 am -
2 stops10h 37m
Sat 10/35:20 am -
2 stops9h 55m
Deal found 8/18![Delta logo]()
$336
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/164:14 pm -
1 stop5h 30m
Wed 9/234:35 pm -
1 stop6h 37m
Deal found 8/16![American Airlines logo]()
$345
This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/37:35 pm -
1 stop4h 24m
Wed 9/94:35 pm -
1 stop6h 37m
Deal found 8/15![American Airlines logo]()
$354
Best flights from Des Moines to McAllenDiscover carefully curated flight deals from Des Moines to McAllen that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 19, 2026.
Discover carefully curated flight deals from Des Moines to McAllen that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 19, 2026.
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:00 am -
2 stops10h 37m
Tue 9/295:20 am -
2 stops11h 28m
Deal found 8/16![Delta logo]()
$305
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:15 am -
1 stop7h 12m
Tue 9/297:00 am -
2 stops9h 20m
Deal found 8/16![United Airlines logo]()
$311
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/37:35 pm -
1 stop4h 24m
Wed 9/94:35 pm -
1 stop6h 37m
Deal found 8/18![American Airlines logo]()
$458
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:00 am -
2 stops10h 37m
Sat 10/312:39 pm -
2 stops8h 32m
Deal found 8/16![Delta logo]()
$305
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:15 am -
1 stop7h 12m
Wed 9/235:19 am -
2 stops9h 01m
Deal found 8/17![United Airlines logo]()
$391
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:40 am -
2 stops12h 59m
Sat 9/55:20 am -
2 stops9h 56m
Deal found 8/17![Delta logo]()
$365
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:00 am -
2 stops9h 59m
Wed 11/47:00 am -
2 stops9h 07m
Deal found 8/14![United Airlines logo]()
$395
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/261:27 pm -
2 stops8h 31m
Sat 10/35:20 am -
2 stops8h 55m
Deal found 8/16![United Airlines logo]()
$396
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/232:58 pm -
2 stops9h 01m
Fri 11/275:20 am -
2 stops11h 29m
Deal found 8/18![Delta logo]()
$468
Last-minute flights from Des Moines to McAllenDiscover last-minute flight deals from Des Moines to McAllen. Data last updated August 19, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to McAllen. Data last updated August 19, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/37:35 pm -
1 stop4h 24m
Wed 9/94:35 pm -
1 stop6h 37m
Deal found 8/15![American Airlines logo]()
$354
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/164:14 pm -
1 stop5h 30m
Wed 9/234:35 pm -
1 stop6h 37m
Deal found 8/16![American Airlines logo]()
$345
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:35 pm -
2 stops8h 24m
Sat 9/265:20 pm -
1 stop4h 56m
Deal found 8/16![United Airlines logo]()
$310
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/194:14 pm -
1 stop5h 30m
Tue 9/294:35 pm -
1 stop6h 37m
Deal found 8/16![American Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:41 am -
1 stop6h 28m
Wed 9/304:35 pm -
1 stop6h 37m
Deal found 8/15![American Airlines logo]()
$301
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/234:14 pm -
1 stop5h 30m
Tue 9/294:35 pm -
1 stop6h 37m
Deal found 8/16![American Airlines logo]()
$295
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:00 am -
2 stops10h 37m
Wed 9/305:20 am -
2 stops11h 28m
Deal found 8/17![Delta logo]()
$305
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:15 am -
1 stop7h 12m
Tue 9/297:00 am -
2 stops9h 20m
Deal found 8/16![United Airlines logo]()
$311
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:00 am -
2 stops10h 37m
Sat 10/35:20 am -
2 stops9h 55m
Deal found 8/18![Delta logo]()
$336
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/234:14 pm -
1 stop5h 30m
Wed 9/305:44 am -
2 stops8h 15m
Deal found 8/16![American Airlines logo]()
$350
One-way flights from Des Moines to McAllenSearch for one-way flight options from Des Moines to McAllen. Find affordable one-way fares based on user searches. Data last updated August 19, 2026.
Search for one-way flight options from Des Moines to McAllen. Find affordable one-way fares based on user searches. Data last updated August 19, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/72:42 pm -
1 stop20h 21m
Deal found 8/14![Allegiant Air logo]()
$178
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:42 pm -
1 stop4h 30m
Deal found 8/16![American Airlines logo]()
$243
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/63:03 pm -
2 stops8h 56m
Deal found 8/16![Delta logo]()
$248
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/63:11 pm -
3 stops17h 42m
Deal found 8/16![United Airlines logo]()
$342
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:00 am -
3 stops15h 58m
Deal found 8/14![United Airlines logo]()
$401
Find flight deals from Des Moines to McAllen
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to McAllen (MFE). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 19, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $295 (American Airlines) |
One-way from | $178 (Kiwi.com) |
Popular in | July |
Cheapest in | November |
Average price | $420 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to McAllen that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 19, 2026.
Use the filters below to find and compare flights from Des Moines to McAllen that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesMcAllen
DSM Des Moines - MFE McAllen Miller Intl
DSMMFE
Des Moines
Wed 9/23
6:00 am-4:37 pm
2 stops10h 37m
McAllen Miller Intl
Tue 9/29
5:20 am-4:48 pm
2 stops11h 28m
$305
Des MoinesMcAllen
DSM Des Moines - MFE McAllen Miller Intl
DSMMFE
Des Moines
Wed 9/23
6:00 am-4:37 pm
2 stops10h 37m
McAllen Miller Intl
Sat 10/3
12:39 pm-9:11 pm
2 stops8h 32m
$305
Des MoinesMcAllen
DSM Des Moines - MFE McAllen Miller Intl
DSMMFE
Des Moines
Wed 9/23
6:15 am-1:27 pm
1 stop7h 12m
McAllen Miller Intl
Tue 9/29
7:00 am-4:20 pm
2 stops9h 20m
$311
Des MoinesMcAllen
DSM Des Moines - MFE McAllen Miller Intl
DSMMFE
Des Moines
Tue 9/1
5:40 am-6:39 pm
2 stops12h 59m
McAllen Miller Intl
Sat 9/5
5:20 am-3:16 pm
2 stops9h 56m
$365
Des MoinesMcAllen
DSM Des Moines - MFE McAllen Miller Intl
DSMMFE
Des Moines
Wed 9/16
6:15 am-1:27 pm
1 stop7h 12m
McAllen Miller Intl
Wed 9/23
5:19 am-2:20 pm
2 stops9h 01m
$391
Des MoinesMcAllen
DSM Des Moines - MFE McAllen Miller Intl
DSMMFE
Des Moines
Sat 10/31
8:00 am-5:59 pm
2 stops9h 59m
McAllen Miller Intl
Wed 11/4
7:00 am-4:07 pm
2 stops9h 07m
$395
Des MoinesMcAllen
DSM Des Moines - MFE McAllen Miller Intl
DSMMFE
Des Moines
Sat 9/26
1:27 pm-9:58 pm
2 stops8h 31m
McAllen Miller Intl
Sat 10/3
5:20 am-2:15 pm
2 stops8h 55m
$396
Quickest round-trip
Des MoinesMcAllen
DSM Des Moines - MFE McAllen Miller Intl
DSMMFE
Des Moines
Thu 9/3
7:35 pm-11:59 pm
1 stop4h 24m
McAllen Miller Intl
Wed 9/9
4:35 pm-11:12 pm
1 stop6h 37m
$458
Des MoinesMcAllen
DSM Des Moines - MFE McAllen Miller Intl
DSMMFE
Des Moines
Mon 11/23
2:58 pm-11:59 pm
2 stops9h 01m
McAllen Miller Intl
Fri 11/27
5:20 am-4:49 pm
2 stops11h 29m
$468
Cheapest one-way
Des MoinesMcAllen
DSM Des Moines - MFE McAllen Miller Intl
DSMMFE
Des Moines
Wed 10/7
2:42 pm-11:03 am
1 stop20h 21m
$178
Showing 1-10 of 13 resultsSorted by cheapest first
Compare providers for flights from Des Moines to McAllen
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to McAllen in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-McAllen flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-McAllen flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-McAllen flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-McAllen flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-McAllen flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to McAllen
Have a flexible travel schedule? Discover the best time to fly to McAllen from Des Moines with our price prediction graph.
DSM-MFE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to McAllen
Prices
More
What’s the top layover airport for flights from Des Moines to McAllen?
Share of 1-stop round-trip flights from Des Moines to McAllen chosen by Cheapflights users in the past 12 months, using the same layover each way.
Houston (IAH) – chosen by Cheapflights users on 50% of 1-stop itineraries from Des Moines to McAllen on Cheapflights.
What’s the cheapest layover airport for flights from Des Moines to McAllen?
Average round-trip fare for 1-stop flights from Des Moines to McAllen, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Dallas (DFW) is the most affordable 1-stop option, with an average round-trip price of $284.
What’s the fastest layover option from Des Moines to McAllen?
Shortest average travel time for 1-stop one-way flights from Des Moines to McAllen, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Houston (IAH) have the shortest average one-way travel time for 1-stop routes: 5h 16m.
Which airport typically offers the quickest layover for flights from Des Moines to McAllen?
Average layover duration for 1-stop one-way flights from Des Moines to McAllen, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Houston (IAH) offer the fastest connection on this route, with an average layover time of 1h 20m.
Reviews of airlines servicing McAllen
Get insights into the airlines that provide service to McAllen. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to McAllen. Reviews last updated August 19, 2026.
Read through reviews of airlines operating flights from Des Moines to McAllen, such as United Airlines and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.7
Food
6.7
Entertainment
7.1
Overall
7.4
Crew
8.1
Comfort
7.3
Reviews
1 / 20
2.0
MediocreIsaac,May 2024
SHV - IAH
Boarding
7.7
Food
6.7
Entertainment
7.1
Overall
7.4
Crew
8.1
Comfort
7.3
Reviews
1 / 20
2.0
MediocreIsaac,May 2024
SHV - IAH
Boarding
7.7
Food
6.7
Entertainment
7.1
Overall
7.4
Crew
8.1
Comfort
7.3
Reviews
1 / 20
2.0
MediocreIsaac,May 2024
SHV - IAH
Related info for your journey
Find useful and relevant information for your journey from Des Moines to McAllen. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near McAllen?
Book flights to McAllen if you plan to visit one of these locationsPharr
Weslaco
Mission
Edinburg
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
McAllen flight routes
Other flight options
Other flights from Des Moines
Popular flights
Alternative routes for Des Moines to McAllen
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to McAllen by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Des Moines to McAllen by cabin class
Find flights from Des Moines to McAllen, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to McAllen
Explore flights to McAllen departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 19, 2026.
Des Moines and McAllen flights
Browse other Des Moines and McAllen flight options. Last updated on August 19, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on August 19, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Des Moines to McAllen
Discover the top 2 airlines that operate flights from Des Moines to McAllen. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 19, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$258 | Average$385 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$283 | Average$315 | FlexibilityNo cancel fee | On-time69% |