Find cheap American Airlines flights to Panama City
RDU — PTY
Nov 3 — Nov 101
Round-trip
1 adult, Economy
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Cheapest American Airlines flights from USA to Panama CityExplore the most affordable American Airlines flight options available from USA to Panama City. Find the lowest fares with prices last updated on October 4, 2026.
Explore the most affordable American Airlines flight options available from USA to Panama City. Find the lowest fares with prices last updated on October 4, 2026.
This American Airlines deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1811:01 am -
Nonstop3h 12m
Wed 11/253:34 pm -
Nonstop3h 13m
Deal found 10/4![American Airlines logo]()
$539
This American Airlines deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1511:01 am -
Nonstop3h 12m
Sun 11/223:34 pm -
Nonstop3h 13m
Deal found 10/4![American Airlines logo]()
$540
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:13 pm -
2 stops18h 49m
Sat 11/73:13 pm -
2 stops17h 50m
Deal found 9/30![American Airlines logo]()
$543
Best American Airlines flights from USA to Panama CityDiscover carefully curated American Airlines flight deals from USA to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 4, 2026.
Discover carefully curated American Airlines flight deals from USA to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 4, 2026.
This American Airlines deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/2310:10 am -
Nonstop3h 16m
Mon 2/14:55 pm -
Nonstop3h 10m
Deal found 10/4![American Airlines logo]()
$502
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/412:38 pm -
Nonstop3h 17m
Mon 2/82:26 pm -
Nonstop3h 08m
Deal found 10/1![American Airlines logo]()
$502
This American Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/1310:11 am -
Nonstop3h 10m
Fri 2/192:39 pm -
Nonstop3h 21m
Deal found 10/2![American Airlines logo]()
$502
Direct American Airlines flights from USA to Panama CityExplore non-stop American Airlines flight options from USA to Panama City based on user searches, and compare prices and availability for your desired travel dates. Data last updated October 4, 2026.
Explore non-stop American Airlines flight options from USA to Panama City based on user searches, and compare prices and availability for your desired travel dates. Data last updated October 4, 2026.
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/411:00 am -
Nonstop3h 13m
Mon 12/73:13 pm -
Nonstop3h 10m
Deal found 9/30![American Airlines logo]()
$502
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1710:11 am -
Nonstop3h 10m
Mon 2/224:04 pm -
Nonstop3h 21m
Deal found 10/1![American Airlines logo]()
$507
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1812:05 pm -
Nonstop3h 09m
Tue 2/234:04 pm -
Nonstop3h 21m
Deal found 9/29![American Airlines logo]()
$522
Last-minute American Airlines flights from USA to Panama CityDiscover last-minute American Airlines flight deals from USA to Panama City. Data last updated October 4, 2026 and is based on user searches.
Discover last-minute American Airlines flight deals from USA to Panama City. Data last updated October 4, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1811:01 am -
Nonstop3h 12m
Wed 11/253:34 pm -
Nonstop3h 13m
Deal found 10/4![American Airlines logo]()
$539
This American Airlines deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1511:01 am -
Nonstop3h 12m
Sun 11/223:34 pm -
Nonstop3h 13m
Deal found 10/4![American Airlines logo]()
$540
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:13 pm -
2 stops18h 49m
Sat 11/73:13 pm -
2 stops17h 50m
Deal found 9/30![American Airlines logo]()
$543
One-way American Airlines flights to Panama CitySearch for one-way American Airlines flight options to Panama City. Find affordable one-way fares based on user searches. Data last updated October 4, 2026.
Search for one-way American Airlines flight options to Panama City. Find affordable one-way fares based on user searches. Data last updated October 4, 2026.
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2911:21 am -
Nonstop3h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![American Airlines logo]()
$221
This American Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/211:00 am -
Nonstop3h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/2![American Airlines logo]()
$226
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1810:11 am -
Nonstop3h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![American Airlines logo]()
$240
Flights to Panama City with American Airlines at a glance
Find detailed information about American Airlines flights from USA to Panama City. Explore the options provided by American Airlines to plan your journey from USA to Panama City. Data last updated October 4, 2026.
Cheapflights Insights
Find cheap American Airlines flights to Panama City
US0-PTY
MIA-PTY
IAD-PTY
How long is the flight to Panama City with American Airlines?
On average, American Airlines flights from the United States to Panama City take 4 hours 18 minutes. Flights to Panama City from other popular cities in the United States will vary in length. Below are a few examples of popular routes and their flight times.
American Airlines weekly flight availability to Panama City
The most flights to Panama City operated by American Airlines are scheduled on a Monday (1 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (1 on average).
When is the best time to book a flight to Panama City with American Airlines?
The best time to book a flight to Panama City with American Airlines is 37 days before departure. On average, fares are higher if you book 8 days before departure.
FAQs about flights to Panama City with American Airlines
Reviews of American Airlines
See what Cheapflights users have to say about their American Airlines experience.
Overview
Reviews
American Airlines
10,000 reviews
Overview
Comfort
7.2
Crew
7.9
Entertainment
6.8
Boarding
7.4
Food
6.4
Recent reviews
10.0
|Sep 2026It was a good experience fast and comfy
8.0
|Sep 2026More organized boarding, actual entertainment screens lol
10.0
|Aug 2026Service Excellent
10.0
|Aug 2026I love everything will fly again thank you 😊
2.0
|Aug 2026Terrible. Will not fly it again. Constant delays. Canceled flight because a pilot didn't show up the AA stated it was weather related. AA is also liars and didn't want to take responsibility or pay. Delayed luggage. Just horrible all the way around. Second time with this. Lost luggage on a previous flight. Back to Delta.
1 out of 3334
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