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Panama City

Find cheap American Airlines flights to Panama City

RDU — PTY
Aug 26 — Sep 21
Wed 8/26
Wed 9/2
1 adult, Economy
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Find American Airlines flight deals to Panama City

Cheapest American Airlines flights from USA to Panama City
Explore the most affordable American Airlines flight options available from USA to Panama City. Find the lowest fares with prices last updated on July 27, 2026.

This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/227:30 am
MCO
-
PTY
1 stop6h 09m
American Airlines
Tue 9/11:39 pm
PTY
-
MCO
2 stops22h 24m
American Airlines
Deal found 7/25$339
This American Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:00 am
MCO
-
PTY
1 stop7h 39m
American Airlines
Sun 8/231:39 pm
PTY
-
MCO
1 stop9h 02m
American Airlines
Deal found 7/24$350
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/237:33 pm
MCO
-
PTY
2 stops18h 06m
American Airlines
Thu 9/31:39 pm
PTY
-
MCO
2 stops23h 33m
American Airlines
Deal found 7/25$353

Flights to Panama City with American Airlines at a glance

Find detailed information about American Airlines flights from USA to Panama City. Explore the options provided by American Airlines to plan your journey from USA to Panama City. Data last updated July 27, 2026.

Popular in

June

Cheapest in

September

Average price

$609

Round-trip from

$339

One-way from

$190
Highest demand for flights to Panama City with American Airlines; 10% potential price increase.
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Best time to find cheap flights to Panama City with American Airlines; 2% potential price drop.
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Average price for flights to Panama City with American Airlines (round-trip).
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American Airlines
  • American Airlines
  • 9/24-9/28
  • 4 total stops
  • 38h 54m total
  • USA to Panama City
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American Airlines
  • American Airlines
  • 8/21
  • 1 total stop
  • 7h 39m total
  • USA to Panama City
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Cheapflights Insights

Find cheap American Airlines flights to Panama City

How long is the flight to Panama City with American Airlines?

On average, American Airlines flights from the United States to Panama City take 4 hours 6 minutes. Flights to Panama City from other popular cities in the United States will vary in length. Below are a few examples of popular routes and their flight times.

American Airlines weekly flight availability to Panama City

The most flights to Panama City operated by American Airlines are scheduled on a Monday (1 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (1 on average).

When is the best time to book a flight to Panama City with American Airlines?

The best time to book a flight to Panama City with American Airlines is 33 days before departure. On average, fares are higher if you book 47 days before departure.

FAQs about flights to Panama City with American Airlines

  • Which airport do American Airlines flights arrive at when travelling to Panama City?

    American Airlines flights on this route tend to land at Panama City Tocumen Intl Airport.

  • Is American Airlines the cheapest airline for a flight to Panama City?

    Flight prices will depend on many factors like date, time and cabin class so it is worth comparing flights before booking. Based on Cheapflights data the cheapest average return price for flights to Panama City tends to be with Spirit Airlines.

  • Are there alternative airlines other than American Airlines that fly to Panama City?

    Copa Airlines, United Airlines and Delta all fly to Panama City and offer an alternative to American Airlines.

  • How much is a flight to Panama City with American Airlines?

    The average price for a return flight with American Airlines is $693; with a one-way flight around $315.

See more FAQs

Reviews of American Airlines

See what Cheapflights users have to say about their American Airlines experience.
American Airlines
7.1
Good
10,000 reviews
Overview

Entertainment

6.8

Crew

7.9

Comfort

7.2

Food

6.4

Boarding

7.5

Popular American Airlines flights

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