$203+ Cheap flights from Panama City (PTY) to Mexico City (MEX)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/24. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MEX
Oct 8 — Oct 151
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to Mexico City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Panama City Tocumen Intl to Mexico City Benito Juarez are usually found in December or January, booked 4 days in advance, depart on a Friday or Sunday and return on a Friday
Cheap flight deals from Panama City to Mexico City
Cheapest
Best
Last-minute
One-way
Cheapest flights from Panama City to Mexico CityExplore the most affordable flight options available from Panama City to Mexico City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 8, 2026.
Explore the most affordable flight options available from Panama City to Mexico City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 8, 2026.
This Avianca deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/246:10 pm -
1 stop10h 00m
Thu 12/311:50 pm -
1 stop10h 30m
Deal found 9/3![Avianca logo]()
$356
This SmartFares deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/143:05 pm -
Nonstop3h 55m
Wed 10/219:05 am -
Nonstop3h 50m
Deal found 9/3![Aeromexico logo]()
$367
This Copa Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/2511:44 am -
Nonstop3h 46m
Thu 12/319:10 am -
Nonstop3h 51m
Deal found 9/3![Copa Airlines logo]()
$375
This FlightHub deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/22:47 pm -
Nonstop3h 53m
Mon 11/98:50 am -
Nonstop3h 56m
Deal found 9/3![Aeromexico logo]()
$376
This Cheapflightsfares deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/163:05 pm -
Nonstop3h 55m
Fri 10/239:05 am -
Nonstop3h 50m
Deal found 9/3![Aeromexico logo]()
$377
This Copa Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/110:17 pm -
Nonstop3h 43m
Sun 11/89:10 am -
Nonstop3h 53m
Deal found 9/7![Copa Airlines logo]()
$386
This Expedia deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/23:05 pm -
Nonstop3h 55m
Fri 10/99:05 am -
Nonstop3h 50m
Deal found 9/5![Aeromexico logo]()
$387
This Trip.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/282:50 pm -
Nonstop3h 50m
Wed 11/48:50 am -
Nonstop3h 56m
Deal found 9/6![Aeromexico logo]()
$390
This Copa Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/259:28 pm -
Nonstop3h 47m
Mon 11/99:10 am -
Nonstop3h 53m
Deal found 9/6![Copa Airlines logo]()
$397
This SmartFares deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/233:05 pm -
Nonstop3h 55m
Wed 9/309:05 am -
Nonstop3h 55m
Deal found 9/3![Aeromexico logo]()
$406
This Copa Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/259:28 pm -
Nonstop3h 47m
Fri 11/65:55 am -
Nonstop3h 52m
Deal found 9/7![Copa Airlines logo]()
$408
This SmartFares deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:50 pm -
Nonstop3h 50m
Sat 11/78:50 am -
Nonstop3h 56m
Deal found 9/7![Aeromexico logo]()
$410
Best flights from Panama City to Mexico CityDiscover carefully curated flight deals from Panama City to Mexico City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 8, 2026.
Discover carefully curated flight deals from Panama City to Mexico City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 8, 2026.
This Copa Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected ” under the list of providers to see comparable flight deals.
Sun 10/410:13 pm -
Nonstop3h 47m
Sun 10/111:10 pm -
Nonstop3h 44m
Deal found 9/3![Copa Airlines logo]()
$386
This Copa Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/59:31 pm -
Nonstop3h 44m
Thu 11/129:10 am -
Nonstop3h 53m
Deal found 9/6![Copa Airlines logo]()
$386
This Copa Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/107:12 pm -
Nonstop3h 53m
Sat 10/179:50 am -
Nonstop3h 48m
Deal found 9/3![Copa Airlines logo]()
$386
This Copa Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/124:12 pm -
Nonstop3h 53m
Mon 10/199:50 am -
Nonstop3h 48m
Deal found 9/7![Copa Airlines logo]()
$386
This Copa Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/49:24 am -
Nonstop3h 46m
Wed 11/119:10 am -
Nonstop3h 53m
Deal found 9/7![Copa Airlines logo]()
$386
This Copa Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/209:24 am -
Nonstop3h 46m
Mon 11/303:30 pm -
Nonstop3h 48m
Deal found 9/4![Copa Airlines logo]()
$386
This Copa Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/54:12 pm -
Nonstop3h 53m
Sun 10/112:10 am -
Nonstop3h 41m
Deal found 9/6![Copa Airlines logo]()
$386
This Copa Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:32 pm -
Nonstop3h 53m
Fri 10/301:20 am -
Nonstop3h 41m
Deal found 9/7![Copa Airlines logo]()
$397
This Copa Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/259:28 pm -
Nonstop3h 47m
Mon 11/99:10 am -
Nonstop3h 53m
Deal found 9/6![Copa Airlines logo]()
$397
This Copa Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/259:28 pm -
Nonstop3h 47m
Fri 11/65:55 am -
Nonstop3h 52m
Deal found 9/7![Copa Airlines logo]()
$408
Last-minute flights from Panama City to Mexico CityDiscover last-minute flight deals from Panama City to Mexico City. Data last updated September 8, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to Mexico City. Data last updated September 8, 2026 and is based on user searches.
This Copa Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/134:12 pm -
Nonstop3h 53m
Sun 9/205:50 am -
Nonstop3h 51m
Deal found 9/6![Copa Airlines logo]()
$521
This Cheapflightsfares deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/143:05 pm -
Nonstop3h 55m
Mon 9/219:05 am -
Nonstop3h 55m
Deal found 9/5![Aeromexico logo]()
$512
This SmartFares deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/162:55 pm -
Nonstop3h 55m
Wed 9/239:05 am -
Nonstop3h 55m
Deal found 9/5![Aeromexico logo]()
$502
This FlightHub deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/162:55 pm -
Nonstop3h 55m
Mon 9/219:05 am -
Nonstop3h 55m
Deal found 9/4![Aeromexico logo]()
$511
This FlightHub deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/165:55 pm -
1 stop30h 05m
Wed 9/234:55 am -
1 stop18h 40m
Deal found 9/8![Avianca logo]()
$554
This FlightHub deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/163:10 pm -
1 stop27h 55m
Wed 9/304:55 pm -
1 stop8h 00m
Deal found 9/7![Avianca logo]()
$555
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1610:12 pm -
Nonstop3h 48m
Tue 9/2212:25 am -
Nonstop3h 41m
Deal found 9/4![Copa Airlines logo]()
$561
This Copa Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/184:12 pm -
Nonstop3h 53m
Fri 9/253:30 pm -
Nonstop3h 44m
Deal found 9/4![Copa Airlines logo]()
$425
This SmartFares deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/183:05 pm -
Nonstop3h 55m
Fri 9/259:05 am -
Nonstop3h 55m
Deal found 9/5![Aeromexico logo]()
$466
This Avianca deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/184:25 am -
1 stop8h 45m
Fri 9/254:55 am -
1 stop8h 20m
Deal found 9/7![Avianca logo]()
$508
One-way flights from Panama City to Mexico CitySearch for one-way flight options from Panama City to Mexico City. Find affordable one-way fares based on user searches. Data last updated September 8, 2026.
Search for one-way flight options from Panama City to Mexico City. Find affordable one-way fares based on user searches. Data last updated September 8, 2026.
This Copa Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/244:21 pm -
Nonstop3h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Copa Airlines logo]()
$203
This Copa Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3011:44 am -
Nonstop3h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Copa Airlines logo]()
$214
This SmartFares deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/173:05 pm -
Nonstop3h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Aeromexico logo]()
$257
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/183:05 pm -
Nonstop3h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Aeromexico logo]()
$268
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/273:05 pm -
Nonstop3h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Aeromexico logo]()
$269
This FlightHub deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/92:50 pm -
Nonstop3h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Aeromexico logo]()
$271
This Super.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/810:13 pm -
Nonstop3h 47m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Copa Airlines logo]()
$274
This Copa Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/264:12 pm -
Nonstop3h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/5![Copa Airlines logo]()
$277
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/277:24 am -
1 stop28h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Multiple Airlines logo]()
$282
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/47:24 am -
1 stop28h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Multiple Airlines logo]()
$283
This SmartFares deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/72:55 pm -
Nonstop4h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Aeromexico logo]()
$286
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:07 pm -
Nonstop3h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Copa Airlines logo]()
$288
Find flight deals from Panama City to Mexico City
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Mexico City (MEX). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 8, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $356 (Avianca) |
One-way from | $203 (Copa Airlines) |
Popular in | October |
Cheapest in | December |
Average price | $413 |
Good round-trip deal | $418 or less |
Good one-way deal | $314 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to Mexico City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 8, 2026.
Use the filters below to find and compare flights from Panama City to Mexico City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CityMexico City
PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez
PTYMEX
Panama City Tocumen Intl
Mon 3/1
2:46 pm-5:45 pm
Nonstop3h 59m
Mexico City Benito Juarez
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$271
Panama CityMexico City
PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez
PTYMEX
Panama City Tocumen Intl
Wed 12/9
2:50 pm-5:40 pm
Nonstop3h 50m
Mexico City Benito Juarez
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$271
Panama CityMexico City
PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez
PTYMEX
Panama City Tocumen Intl
Fri 10/23
4:12 pm-7:05 pm
Nonstop3h 53m
Mexico City Benito Juarez
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$277
Panama CityMexico City
PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez
PTYMEX
Panama City Tocumen Intl
Sun 10/4
10:13 pm-1:00 am
Nonstop3h 47m
Mexico City Benito Juarez
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$277
Panama CityMexico City
PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez
PTYMEX
Panama City Tocumen Intl
Sat 9/26
4:12 pm-7:05 pm
Nonstop3h 53m
Mexico City Benito Juarez
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$277
Panama CityMexico City
PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez
PTYMEX
Panama City Tocumen Intl
Mon 11/16
9:24 am-12:10 pm
Nonstop3h 46m
Mexico City Benito Juarez
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$277
Panama CityMexico City
PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez
PTYMEX
Panama City Tocumen Intl
Wed 10/21
4:12 pm-7:05 pm
Nonstop3h 53m
Mexico City Benito Juarez
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$277
Quickest round-trip
Panama CityMexico City
PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez
PTYMEX
Panama City Tocumen Intl
Sun 11/1
9:31 pm-12:15 am
Nonstop3h 44m
Mexico City Benito Juarez
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$277
Panama CityMexico City
PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez
PTYMEX
Panama City Tocumen Intl
Sun 10/4
10:13 pm-1:00 am
Nonstop3h 47m
Mexico City Benito Juarez
Sun 10/11
1:10 pm-5:54 pm
Nonstop3h 44m
$386
Panama CityMexico City
PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez
PTYMEX
Panama City Tocumen Intl
Thu 11/5
9:31 pm-12:15 am
Nonstop3h 44m
Mexico City Benito Juarez
Thu 11/12
9:10 am-2:03 pm
Nonstop3h 53m
$386
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Panama City to Mexico City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Mexico City in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City-Mexico City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Mexico City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Mexico City flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City-Mexico City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Mexico City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to Mexico City
Have a flexible travel schedule? Discover the best time to fly to Mexico City from Panama City with our price prediction graph.
PTY-MEX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to Mexico City
Prices
Airlines
Delays
How far ahead should I book a flight from Panama City to Mexico City?
The price you pay for your flight from Panama City to Mexico City may vary depending on when you book. For the best chance of a lower fare, look to book 3 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Panama City to Mexico City?
Currently, December is the cheapest month in which you can book a flight from Panama City to Mexico City (average of $342). Flying from Panama City to Mexico City in October is currently the most expensive (average of $486). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PTY to MEX?
Find hourly flight availability from Panama City to Mexico City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 8, 2026.
It’s typically best to fly out from Panama City to Mexico City in the evening. Doing so could potentially save you 21% on the flight price compared to flying in the afternoon, which is usually more expensive.
What is the cheapest day to fly from Panama City to Mexico City?
Use this chart to determine the cheapest time to fly round-trip from Panama City to Mexico City. Price data was last updated on August 29, 2026.
Travelers seeking maximum savings on their Panama City to Mexico City flight should consider departing on Tuesday evenings when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.
How often are flights from Panama City to Mexico City delayed?
About 4% of weekly flights between Panama City and Mexico City have experienced delays in the past year, with the average delay time being 122 minutes.
What is the most punctual flight time for Panama City to Mexico City flights?
Historically, flights departing in the morning are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Thursday tends to have the lowest number of delays on this route, whereas Sunday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Panama City to Mexico City flights?
Over the last year, Copa Airlines have had the lowest number of delays on this route, with just 3% of flights being delayed.
The best insider tips for Panama City to Mexico City flights
AI-powered summary based on content written by travel experts. AI can make mistakes.
Cheapflights partnered with top experts to bring you the best recommendations for your Panama City to Mexico City trip
Our travel experts
Reviews of airlines servicing Mexico City
Get insights into the airlines that provide service to Mexico City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico City. Reviews last updated September 8, 2026.
See what other customers who have flown with Copa Airlines,Aeromexico, andAvianca from Panama City to Mexico City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
6.9
Comfort
7.4
Food
6.9
Crew
8.1
Overall
7.6
Boarding
7.8
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Entertainment
6.9
Comfort
7.4
Food
6.9
Crew
8.1
Overall
7.6
Boarding
7.8
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Entertainment
6.9
Comfort
7.4
Food
6.9
Crew
8.1
Overall
7.6
Boarding
7.8
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Entertainment
6.9
Comfort
7.4
Food
6.9
Crew
8.1
Overall
7.6
Boarding
7.8
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Related info for your journey
Find useful and relevant information for your journey from Panama City to Mexico City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Mexico City?
Book flights to Mexico City if you plan to visit one of these locationsTaxco
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Other flights to Mexico City
Explore flights to Mexico City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 8, 2026.
Panama City and Mexico City flights
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Top 3 airlines flying from Panama City to Mexico City
Discover the top 3 airlines that operate flights from Panama City to Mexico City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 8, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$175 | Average$384 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$193 | Average$410 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$320 | Average$467 | FlexibilityNo cancel fee | On-time71% |