$266+ Cheap flights from Panama City (PTY) to San Diego (SAN)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/9. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SAN
Aug 26 — Sep 21
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Panama City to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to San Diego
Cheapest
Best
Last-minute
One-way
Cheapest flights from Panama City to San DiegoExplore the most affordable flight options available from Panama City to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 27, 2026.
Explore the most affordable flight options available from Panama City to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 27, 2026.
This American Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/53:13 pm
PTY
- SAN
2 stops22h 05m
American Airlines
Tue 11/101:05 pm
SAN
- PTY
2 stops22h 08m
American Airlines
Deal found 7/24![American Airlines logo]()
$320
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/28:55 am
PTY
- SAN
1 stop14h 02m
United Airlines
Sun 12/65:00 pm
SAN
- PTY
2 stops23h 38m
United Airlines
Deal found 7/26![United Airlines logo]()
$328
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/22:50 pm
PTY
- SAN
2 stops20h 38m
American Airlines
Sun 12/62:36 pm
SAN
- PTY
2 stops20h 12m
American Airlines
Deal found 7/26![American Airlines logo]()
$359
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/243:30 pm
PTY
- SAN
2 stops22h 01m
United Airlines
Tue 10/273:04 pm
SAN
- PTY
1 stop25h 34m
United Airlines
Deal found 7/25![United Airlines logo]()
$360
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/133:30 pm
PTY
- SAN
2 stops27h 56m
United Airlines
Fri 9/185:00 pm
SAN
- PTY
2 stops19h 14m
United Airlines
Deal found 7/26![United Airlines logo]()
$393
This KAYAK deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/243:30 pm
PTY
- SAN
2 stops33h 00m
Copa Airlines
Tue 10/278:05 am
SAN
- PTY
1 stop8h 33m
Copa Airlines
Deal found 7/25![Copa Airlines logo]()
$423
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/144:41 pm
PTY
- SAN
2 stops22h 32m
United Airlines
Tue 1/124:06 pm
SAN
- PTY
2 stops19h 39m
United Airlines
Deal found 7/25![United Airlines logo]()
$455
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:55 am
PTY
- SAN
1 stop11h 58m
United Airlines
Mon 11/27:41 pm
SAN
- PTY
2 stops20h 57m
United Airlines
Deal found 7/25![United Airlines logo]()
$460
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:41 pm
PTY
- SAN
1 stop29h 12m
United Airlines
Thu 11/55:00 pm
SAN
- PTY
1 stop18h 45m
United Airlines
Deal found 7/26![United Airlines logo]()
$478
Best flights from Panama City to San DiegoDiscover carefully curated flight deals from Panama City to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 27, 2026.
Discover carefully curated flight deals from Panama City to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 27, 2026.
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/243:30 pm
PTY
- SAN
2 stops22h 01m
United Airlines
Tue 10/274:45 pm
SAN
- PTY
2 stops23h 53m
United Airlines
Deal found 7/25![United Airlines logo]()
$360
This Copa Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/131:54 pm
PTY
- SAN
Nonstop6h 35m
Copa Airlines
Fri 9/1810:00 pm
SAN
- PTY
Nonstop6h 17m
Copa Airlines
Deal found 7/25![Copa Airlines logo]()
$558
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/133:30 pm
PTY
- SAN
2 stops22h 05m
United Airlines
Mon 9/283:00 pm
SAN
- PTY
1 stop25h 37m
United Airlines
Deal found 7/26![United Airlines logo]()
$360
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/133:30 pm
PTY
- SAN
2 stops22h 05m
United Airlines
Fri 9/182:24 pm
SAN
- PTY
2 stops21h 50m
United Airlines
Deal found 7/25![United Airlines logo]()
$393
This Copa Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/301:54 pm
PTY
- SAN
Nonstop6h 35m
Copa Airlines
Wed 10/710:00 pm
SAN
- PTY
Nonstop6h 13m
Copa Airlines
Deal found 7/23![Copa Airlines logo]()
$558
Last-minute flights from Panama City to San DiegoDiscover last-minute flight deals from Panama City to San Diego. Data last updated July 27, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to San Diego. Data last updated July 27, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/281:14 pm
PTY
- SAN
1 stop11h 24m
American Airlines
Tue 8/410:25 pm
SAN
- PTY
1 stop12h 14m
American Airlines
Deal found 7/24![American Airlines logo]()
$811
This Mytrip deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/285:30 am
PTY
- SAN
3 stops30h 38m
Multiple Airlines
Tue 8/410:04 am
SAN
- PTY
2 stops13h 51m
Multiple Airlines
Deal found 7/24![Multiple Airlines logo]()
$1,012
This Mytrip deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/285:30 am
PTY
- SAN
3 stops30h 38m
Avianca
Tue 8/410:49 am
SAN
- PTY
3 stops26h 06m
Avianca
Deal found 7/24![Avianca logo]()
$1,131
This Copa Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:01 pm
PTY
- SAN
Nonstop6h 29m
Copa Airlines
Fri 8/2810:00 pm
SAN
- PTY
Nonstop6h 22m
Copa Airlines
Deal found 7/24![Copa Airlines logo]()
$558
This United Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/213:30 pm
PTY
- SAN
2 stops23h 11m
United Airlines
Fri 8/284:07 pm
SAN
- PTY
2 stops20h 07m
United Airlines
Deal found 7/24![United Airlines logo]()
$564
This Expedia deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/213:50 pm
PTY
- SAN
3 stops29h 11m
Multiple Airlines
Fri 8/285:22 pm
SAN
- PTY
2 stops30h 33m
Multiple Airlines
Deal found 7/24![Multiple Airlines logo]()
$854
One-way flights from Panama City to San DiegoSearch for one-way flight options from Panama City to San Diego. Find affordable one-way fares based on user searches. Data last updated July 27, 2026.
Search for one-way flight options from Panama City to San Diego. Find affordable one-way fares based on user searches. Data last updated July 27, 2026.
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/91:52 pm
PTY
- SAN
1 stop10h 51m
American Airlines
Deal found 7/27![American Airlines logo]()
$266
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/171:16 pm
PTY
- SAN
2 stops12h 39m
American Airlines
Deal found 7/23![American Airlines logo]()
$284
This American Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/221:16 pm
PTY
- SAN
2 stops24h 59m
American Airlines
Deal found 7/24![American Airlines logo]()
$297
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/211:16 pm
PTY
- SAN
2 stops24h 47m
American Airlines
Deal found 7/23![American Airlines logo]()
$348
This Kiwi.com deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2110:10 am
PTY
- SAN
3 stops31h 31m
Multiple Airlines
Deal found 7/23![Multiple Airlines logo]()
$381
This eDestinos deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/23:50 pm
PTY
- SAN
2 stops30h 18m
Multiple Airlines
Deal found 7/26![Multiple Airlines logo]()
$411
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/219:33 pm
PTY
- SAN
3 stops22h 45m
Multiple Airlines
Deal found 7/22![Multiple Airlines logo]()
$425
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/229:45 pm
PTY
- SAN
3 stops36h 40m
Multiple Airlines
Deal found 7/24![Multiple Airlines logo]()
$434
This FlightHub deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/93:50 pm
PTY
- SAN
2 stops24h 45m
Multiple Airlines
Deal found 7/23![Multiple Airlines logo]()
$457
Find flight deals from Panama City to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 27, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $320 (American Airlines) |
One-way from | $266 (American Airlines) |
Popular in | June |
Cheapest in | November |
Average price | $671 |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 27, 2026.
Use the filters below to find and compare flights from Panama City to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CitySan Diego
PTY - SAN
PTYSAN
Panama City Tocumen Intl
Sat 10/24
3:30 pm-11:31 am
2 stops22h 01m
San Diego
Tue 10/27
4:45 pm-6:38 pm
2 stops23h 53m
$360
Panama CitySan Diego
PTY - SAN
PTYSAN
Panama City Tocumen Intl
Sun 9/13
3:30 pm-11:35 am
2 stops22h 05m
San Diego
Mon 9/28
3:00 pm-6:37 pm
1 stop25h 37m
$360
Panama CitySan Diego
PTY - SAN
PTYSAN
Panama City Tocumen Intl
Sun 9/13
3:30 pm-11:35 am
2 stops22h 05m
San Diego
Fri 9/18
2:24 pm-2:14 pm
2 stops21h 50m
$393
Panama CitySan Diego
PTY - SAN
PTYSAN
Panama City Tocumen Intl
Sun 9/13
1:54 pm-6:29 pm
Nonstop6h 35m
San Diego
Fri 9/18
10:00 pm-6:17 am
Nonstop6h 17m
$558
Quickest round-trip
Panama CitySan Diego
PTY - SAN
PTYSAN
Panama City Tocumen Intl
Wed 9/30
1:54 pm-6:29 pm
Nonstop6h 35m
San Diego
Wed 10/7
10:00 pm-6:13 am
Nonstop6h 13m
$558
Cheapest one-way
Panama CitySan Diego
PTY - SAN
PTYSAN
Panama City Tocumen Intl
Thu 9/3
1:39 pm-10:07 am
2 stops22h 28m
$276
Panama CitySan Diego
PTY - SAN
PTYSAN
Panama City Tocumen Intl
Fri 10/9
10:00 am-9:24 pm
1 stop13h 24m
$523
Panama CitySan Diego
PTY - SAN
PTYSAN
Panama City Tocumen Intl
Fri 10/9
11:25 am-8:08 pm
3 stops34h 43m
$559
Quickest one-way
Panama CitySan Diego
PTY - SAN
PTYSAN
Panama City Tocumen Intl
Wed 10/21
1:48 pm-6:30 pm
Nonstop6h 42m
$598
Panama CitySan Diego
PTY - SAN
PTYSAN
Panama City Tocumen Intl
Sun 8/2
7:55 am-9:24 pm
1 stop15h 29m
$600
Showing 1-10 of 14 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on Panama City-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Panama City with our price prediction graph.
PTY-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to San Diego
What is the cheapest month to book a flight from Panama City to San Diego?
Currently, November is the cheapest month in which you can book a flight from Panama City to San Diego (average of $434). Flying from Panama City to San Diego in June is currently the most expensive (average of $1,217). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PTY to SAN?
Find hourly flight availability from Panama City to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 27, 2026.
When flying from Panama City to San Diego, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated July 27, 2026.
Peruse reviews from past customers who have flown with Copa Airlines and United Airlines from Panama City to San Diego to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
6.9
Crew
8.1
Overall
7.6
Boarding
7.8
Entertainment
6.8
Comfort
7.4
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Food
6.9
Crew
8.1
Overall
7.6
Boarding
7.8
Entertainment
6.8
Comfort
7.4
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Food
6.9
Crew
8.1
Overall
7.6
Boarding
7.8
Entertainment
6.8
Comfort
7.4
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Related info for your journey
Find useful and relevant information for your journey from Panama City to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
National City
Chula Vista
Poway
La Mesa
Coronado
Santee
San Ysidro
Julian
Lemon Grove
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Panama City
Popular flights
San Diego flight routes
Alternative routes for Panama City to San Diego
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to San Diego by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Panama City to San Diego by cabin class
Find flights from Panama City to San Diego, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Panama City and San Diego flights
Browse other Panama City and San Diego flight options. Last updated on July 27, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on July 27, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Diego
Explore flights to San Diego departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 27, 2026.
Top 2 airlines flying from Panama City to San Diego
Discover the top 2 airlines that operate flights from Panama City to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 27, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$297 | Average$686 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$490 | Average$722 | FlexibilityNo cancel fee | On-time69% |