$369+ Cheap flights from Panama City (PTY) to San Diego (SAN)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/9. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SAN
Nov 23 — Nov 301
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to San Diego
Cheapest
Best
Last-minute
One-way
Cheapest flights from Panama City to San DiegoExplore the most affordable flight options available from Panama City to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 24, 2026.
Explore the most affordable flight options available from Panama City to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 24, 2026.
This Copa Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/11:45 pm -
Nonstop6h 30m
Wed 11/1110:30 pm -
Nonstop6h 06m
Deal found 10/22![Copa Airlines logo]()
$676
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/34:41 pm -
1 stop21h 18m
Mon 11/95:00 pm -
1 stop18h 45m
Deal found 10/22![United Airlines logo]()
$682
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/118:55 am -
1 stop9h 59m
Sun 11/158:05 am -
1 stop8h 33m
Deal found 10/20![United Airlines logo]()
$691
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/232:24 pm -
1 stop11h 00m
Thu 10/2912:38 pm -
1 stop22h 21m
Deal found 10/22![Delta logo]()
$703
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/21:45 pm -
Nonstop6h 30m
Wed 11/1110:30 pm -
Nonstop6h 06m
Deal found 10/22![Copa Airlines logo]()
$717
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/61:45 pm -
Nonstop6h 30m
Wed 11/1110:30 pm -
Nonstop6h 06m
Deal found 10/22![Copa Airlines logo]()
$720
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/222:41 pm -
1 stop12h 18m
Mon 1/49:25 pm -
2 stops15h 08m
Deal found 10/21![American Airlines logo]()
$725
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/33:13 pm -
2 stops25h 02m
Tue 12/81:06 pm -
2 stops22h 07m
Deal found 10/23![American Airlines logo]()
$726
This BusinessClass deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:02 pm -
2 stops23h 54m
Mon 11/91:29 pm -
2 stops21h 44m
Deal found 10/24![GOL logo]()
$733
Best flights from Panama City to San DiegoDiscover carefully curated flight deals from Panama City to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 24, 2026.
Discover carefully curated flight deals from Panama City to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 24, 2026.
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/43:24 pm -
1 stop28h 01m
Sat 11/712:38 pm -
1 stop22h 21m
Deal found 10/22![Delta logo]()
$682
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/118:55 am -
1 stop9h 59m
Sun 11/158:05 am -
1 stop8h 33m
Deal found 10/24![United Airlines logo]()
$691
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/43:24 pm -
1 stop28h 01m
Tue 11/102:33 pm -
1 stop20h 29m
Deal found 10/22![Delta logo]()
$682
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/44:41 pm -
2 stops18h 59m
Thu 11/128:05 am -
1 stop8h 33m
Deal found 10/22![United Airlines logo]()
$762
Last-minute flights from Panama City to San DiegoDiscover last-minute flight deals from Panama City to San Diego. Data last updated October 24, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to San Diego. Data last updated October 24, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/232:24 pm -
1 stop11h 00m
Thu 10/2912:38 pm -
1 stop22h 21m
Deal found 10/22![Delta logo]()
$703
This BusinessClass deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:02 pm -
2 stops23h 54m
Mon 11/91:29 pm -
2 stops21h 44m
Deal found 10/24![GOL logo]()
$733
This Copa Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/11:45 pm -
Nonstop6h 30m
Wed 11/1110:30 pm -
Nonstop6h 06m
Deal found 10/22![Copa Airlines logo]()
$676
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/21:45 pm -
Nonstop6h 30m
Wed 11/1110:30 pm -
Nonstop6h 06m
Deal found 10/22![Copa Airlines logo]()
$717
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/38:55 am -
1 stop11h 58m
Tue 11/104:45 pm -
2 stops19h 00m
Deal found 10/22![United Airlines logo]()
$682
This KAYAK deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/38:55 am -
1 stop11h 58m
Mon 11/95:00 pm -
1 stop18h 45m
Deal found 10/22![Copa Airlines logo]()
$740
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/38:55 am -
1 stop9h 59m
Thu 11/128:05 am -
1 stop8h 33m
Deal found 10/22![United Airlines logo]()
$748
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/61:45 pm -
Nonstop6h 30m
Wed 11/1110:30 pm -
Nonstop6h 06m
Deal found 10/22![Copa Airlines logo]()
$720
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/118:55 am -
1 stop9h 59m
Sun 11/158:05 am -
1 stop8h 33m
Deal found 10/20![United Airlines logo]()
$691
One-way flights from Panama City to San DiegoSearch for one-way flight options from Panama City to San Diego. Find affordable one-way fares based on user searches. Data last updated October 24, 2026.
Search for one-way flight options from Panama City to San Diego. Find affordable one-way fares based on user searches. Data last updated October 24, 2026.
This Copa Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/91:45 pm -
Nonstop6h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Copa Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/93:29 pm -
1 stop11h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Delta logo]()
$374
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/98:55 am -
1 stop10h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![United Airlines logo]()
$379
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/153:13 pm -
1 stop22h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![American Airlines logo]()
$390
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:41 pm -
1 stop27h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![United Airlines logo]()
$392
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/291:45 pm -
Nonstop6h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Copa Airlines logo]()
$401
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/163:13 pm -
2 stops21h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![American Airlines logo]()
$414
Find flight deals from Panama City to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $682 (United Airlines) |
One-way from | $369 (Copa Airlines) |
Popular in | June |
Cheapest in | November |
Average price | $677 |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 24, 2026.
Use the filters below to find and compare flights from Panama City to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Mon 12/7
11:35 am-8:08 pm
2 stops11h 33m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$374
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Wed 12/9
3:29 pm-11:38 pm
1 stop11h 09m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$374
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Fri 10/30
3:41 pm-1:24 pm
1 stop23h 43m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$374
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Wed 12/9
8:55 am-4:00 pm
1 stop10h 05m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$379
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Mon 11/2
8:55 am-9:26 pm
1 stop15h 31m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$379
Quickest round-trip
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Thu 10/29
7:55 am-3:54 pm
1 stop9h 59m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$379
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Wed 11/4
3:24 pm-4:25 pm
1 stop28h 01m
San Diego
Sat 11/7
12:38 pm-1:59 pm
1 stop22h 21m
$682
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Wed 11/4
3:24 pm-4:25 pm
1 stop28h 01m
San Diego
Tue 11/10
2:33 pm-2:02 pm
1 stop20h 29m
$682
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Wed 11/11
8:55 am-3:54 pm
1 stop9h 59m
San Diego
Sun 11/15
8:05 am-7:38 pm
1 stop8h 33m
$691
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Wed 11/4
4:41 pm-8:40 am
2 stops18h 59m
San Diego
Thu 11/12
8:05 am-7:38 pm
1 stop8h 33m
$762
Sorted by cheapest first
- Most accurate provider: When it comes to deals on Panama City-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Panama City with our price prediction graph.
PTY-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to San Diego
What is the cheapest month to book a flight from Panama City to San Diego?
Currently, November is the cheapest month in which you can book a flight from Panama City to San Diego (average of $434). Flying from Panama City to San Diego in June is currently the most expensive (average of $1,217). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PTY to SAN?
Find hourly flight availability from Panama City to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 24, 2026.
When flying from Panama City to San Diego, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated October 24, 2026.
Peruse reviews from past customers who have flown with Copa Airlines and United Airlines from Panama City to San Diego to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.8
Food
7.0
Entertainment
6.9
Comfort
7.4
Crew
8.1
Overall
7.6
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Boarding
7.8
Food
7.0
Entertainment
6.9
Comfort
7.4
Crew
8.1
Overall
7.6
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Boarding
7.8
Food
7.0
Entertainment
6.9
Comfort
7.4
Crew
8.1
Overall
7.6
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Related info for your journey
Find useful and relevant information for your journey from Panama City to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
National City
Chula Vista
San Ysidro
Poway
Coronado
La Mesa
Julian
Santee
Lemon Grove
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Panama City and San Diego flights
Browse other Panama City and San Diego flight options. Last updated on October 24, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on October 24, 2026.
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Check out other popular destinations found by fellow travelers in 2026
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Explore flights to San Diego departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 24, 2026.
Top 2 airlines flying from Panama City to San Diego
Discover the top 2 airlines that operate flights from Panama City to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$339 | Average$722 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$436 | Average$714 | FlexibilityNo cancel fee | On-time70% |