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$333+ Cheap flights from Panama City (PTY) to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/17. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SAN
May 25 — Jun 11
Mon 5/25
Mon 6/1
1 adult, Economy
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Cheap flight deals from Panama City to San Diego

Cheapest flights from Panama City to San Diego
Explore the most affordable flight options available from Panama City to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 25, 2026.

This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/21:49 pm
PTY
-
SAN
1 stop10h 39m
American Airlines
Sun 5/2412:36 pm
SAN
-
PTY
1 stop21h 38m
American Airlines
Deal found 4/20$678
This Copa Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/112:01 pm
PTY
-
SAN
Nonstop6h 56m
Copa Airlines
Mon 11/1610:00 pm
SAN
-
PTY
Nonstop6h 04m
Copa Airlines
Deal found 4/25$714
This United Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/210:00 am
PTY
-
SAN
2 stops14h 25m
United Airlines
Fri 7/1010:49 am
SAN
-
PTY
2 stops25h 25m
United Airlines
Deal found 4/24$716
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/223:30 pm
PTY
-
SAN
2 stops18h 52m
United Airlines
Sun 7/266:20 am
SAN
-
PTY
2 stops10h 17m
United Airlines
Deal found 4/21$720
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/112:43 pm
PTY
-
SAN
1 stop10h 39m
American Airlines
Mon 11/1610:35 pm
SAN
-
PTY
1 stop12h 01m
American Airlines
Deal found 4/25$729
This Copa Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/72:01 pm
PTY
-
SAN
Nonstop6h 29m
Copa Airlines
Mon 8/108:58 pm
SAN
-
PTY
Nonstop6h 22m
Copa Airlines
Deal found 4/21$730
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:35 pm
PTY
-
SAN
2 stops23h 25m
American Airlines
Wed 11/47:30 pm
SAN
-
PTY
2 stops15h 06m
American Airlines
Deal found 4/23$733
This United Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/127:55 am
PTY
-
SAN
2 stops17h 59m
United Airlines
Sat 7/188:42 pm
SAN
-
PTY
2 stops19h 55m
United Airlines
Deal found 4/24$736

Find flight deals from Panama City to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 25, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$714
(Copa Airlines)

One-way from

$333
(Kiwi.com)

Popular in

April

Cheapest in

October

Average price

$784

Good round-trip deal

$516 or less
Provider with most accurate pricing for Panama City Tocumen Intl-San Diego flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-San Diego flights.
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From Panama City Tocumen Intl to San Diego
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One-way flight from Panama City Tocumen Intl to San Diego
Search Deals
Highest demand for flights based on searches. 19% potential increase in price ($142 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($19 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals
Price to beat on a round-trip flight from Panama City Tocumen Intl to San Diego.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 25, 2026.
Use the filters below to find and compare flights from Panama City to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 7/2

7:55 am-5:41 pm

1 stop11h 46m

San Diego

Fri 7/10

10:13 am-6:37 pm

1 stop30h 24m

$718

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 7/24

3:30 pm-10:08 am

2 stops20h 38m

San Diego

Mon 7/27

6:20 am-2:14 pm

2 stops29h 54m

$720

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 8/7

3:30 pm-9:24 pm

1 stop31h 54m

San Diego

Mon 8/10

8:32 pm-6:37 pm

2 stops20h 05m

$720
Quickest round-trip

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 7/22

3:30 pm-9:05 am

2 stops19h 35m

San Diego

Sun 7/26

8:32 pm-4:12 pm

2 stops17h 40m

$720
Cheapest one-way

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sun 5/17

9:33 pm-9:04 pm

3 stops49h 31m

$333

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Tue 5/5

9:33 pm-11:12 pm

3 stops27h 39m

$400

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sat 5/23

3:50 pm-2:38 pm

2 stops24h 48m

$411

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sat 5/16

5:30 am-2:38 pm

2 stops35h 08m

$435

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 6/19

4:25 am-3:32 pm

3 stops37h 07m

$501

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sun 6/14

3:50 pm-7:34 pm

3 stops29h 44m

$525

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/20

Showing 1-10 of 13 resultsSorted by cheapest first
1
2
  • Most accurate provider: When it comes to deals on Panama City-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-San Diego flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to San Diego

What is the cheapest month to book a flight from Panama City to San Diego?

Currently, October is the cheapest month in which you can book a flight from Panama City to San Diego (average of $394). Flying from Panama City to San Diego in April is currently the most expensive (average of $784). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SAN?

Find hourly flight availability from Panama City to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 25, 2026.

When flying from Panama City to San Diego, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost to fly round-trip from Panama City to San Diego?

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated April 25, 2026.
Peruse reviews from past customers who have flown with Copa Airlines and United Airlines from Panama City to San Diego to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,578 reviews

Crew

8.1

Boarding

7.8

Overall

7.5

Comfort

7.4

Food

6.8

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Copa Airlines
7.5
Good
1,578 reviews
Copa Airlines
7.5
Good
1,578 reviews

Crew

8.1

Boarding

7.8

Overall

7.5

Comfort

7.4

Food

6.8

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
United Airlines
7.4
Good
9,650 reviews
Copa Airlines
7.5
Good
1,578 reviews

Crew

8.1

Boarding

7.8

Overall

7.5

Comfort

7.4

Food

6.8

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it

Related info for your journey

Find useful and relevant information for your journey from Panama City to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to San Diego?

    Booking a flight from Panama City Tocumen Intl (PTY) to San Diego (SAN) is your only option if you wish to fly from Panama City to San Diego. On a typical day, there is 1 flight from Tocumen Intl to San Diego, all of which are around 6h 29m for a nonstop flight. You can also purchase a plane ticket from 2 airlines when you book a flight from Tocumen Intl to San Diego.

  • How long is the flight from Panama City to San Diego?

    A quick flight from Panama City to San Diego can take about 11h 46m. United Airlines provides one of the quickest options available for as low as $718. Airlines will cover a distance of 2910 mi.

  • What are the cheapest airlines flying from Panama City to San Diego round-trip?

    Copa Airlines, at $224, was found to be the cheapest airline from Panama City to San Diego. An alternate airline flying to your destination would be United Airlines. Users have found that Copa Airlines is 61% cheaper than the other options available to this destination.

  • What are the cheapest flights from Panama City to San Diego?

    On average you can expect to pay $686 for a flight from Panama City to San Diego. The cheapest flight overall is $516 while the most popular route, (Panama City Tocumen Intl - San Diego) is currently priced at $679.

  • Can I find deals for flights from Panama City to San Diego that include hotel bookings?

    Yes. In addition to deals on Panama City to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Diego.

  • Can I find deals for business class flights from Panama City to San Diego?

    Yes. Cheapflights offers flight deals from Panama City to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to San Diego?

    Currently, October is the cheapest month in which you can book a flight from Panama City to San Diego (average of $394). Flying from Panama City to San Diego in April is currently the most expensive (average of $784). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Panama City to San Diego

Discover the top 2 airlines that operate flights from Panama City to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 25, 2026.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$224Average$494FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$361Average$704FlexibilityNo cancel feeOn-time69%

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