How popular is this Panama City to San Francisco flight route?

The Panama City Tocumen Intl to San Francisco flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

What are the cheapest airlines flying from Panama City to San Francisco round-trip?

Cheapflights users have booked flights from Panama City to San Francisco round-trip from $497. Other airlines that can offer you cheap pricing are United Airlines, from $507, and Delta, from $512. Avianca is priced at 20% lower than the current average price of a flight leaving 3 months from now.

What are the cheapest airlines to fly from Panama City to San Francisco one-way?

The cheapest airlines for a one-way flight from Panama City to San Francisco are Avianca ($286), United Airlines ($462), and Copa Airlines ($653).

What is the cheapest day to fly from Panama City to San Francisco?

Travelers seeking maximum savings on their Panama City to San Francisco flight should consider departing on Sunday mornings when fares are most often at their lowest. Friday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

What are the cheapest flights from Panama City to San Francisco?

The cheapest flight price from Panama City to San Francisco is $306. On average you can expect to pay $846. The most popular route, (Panama City Tocumen Intl - San Francisco), can usually be booked for $495.

What are the most popular airlines that fly from Panama City to San Francisco?

When booking a flight from Panama City to San Francisco, you may want to consider flying on Avianca, Copa Airlines or United Airlines as they are the most popular for this route.

What is the cheapest day to fly round-trip from Panama City to San Francisco?

Flying to your destination on a Thursday can be more expensive, but this shouldn’t discourage you from finding affordable options to get to San Francisco. Check prices with Cheapflights to find a great deal for your trip.

How far in advance should I book a flight from Panama City to San Francisco?

Find a great deal and save up to 30% by booking at least 53 days prior to your desired departure date, rather than waiting until the week of travel. According to our data, there are a number of flights available from Panama City to San Francisco within the next two weeks, with the cheapest ticket starting at $535.

What is the cheapest month to fly from Panama City to San Francisco?

Our data shows that August tends to be the cheapest month to fly to San Francisco from Panama City. Users have commonly found prices around $628 for the month, but tickets can be as low as $219. Due to multiple factors, prepare for potentially higher prices in March.

What airports do I use to fly from Panama City to San Francisco?

If you book a flight from Panama City to San Francisco, you will be flying from Tocumen Intl to San Francisco. Flights to San Francisco (SFO) from Panama City Tocumen Intl (PTY) take 7h 35m for a nonstop flight. There are 4 flights from Tocumen Intl to San Francisco per day from 3 airlines.

Can I find deals for flights from Panama City to San Francisco that include hotel bookings?

Yes. In addition to deals on Panama City to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Panama City to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Francisco.

Can I find deals for business class flights from Panama City to San Francisco?

Yes. Cheapflights offers flight deals from Panama City to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$286+ Flights from Panama City to San Francisco

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

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Cheapflights Tip: The best prices from Panama City Tocumen Intl to San Francisco are usually found in August or June, booked 65 days in advance, depart on a Thursday or Monday and return on a Tuesday

Cheap flight deals from Panama City to San Francisco

Round-trip from	$497 (Priceline)
One-way from	$286 (FlightHub)
Popular in	March
Cheapest in	August
Average price	$619
Good round-trip deal	$602 or less
Good one-way deal	$374 or less

From Panama City Tocumen Intl to San Francisco

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One-way flight from Panama City Tocumen Intl to San Francisco

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Highest demand for flights based on searches. 3% potential increase in price ($24 potential increase over avg. RT price).

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Cheapest flight prices on average. 0% potential price decrease ($6 potential savings vs. average RT price).

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Average for round-trip flights in July 2025

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Price to beat on a round-trip flight from Panama City Tocumen Intl to San Francisco.

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Price to beat on a one-way flight from Panama City Tocumen Intl to San Francisco.

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Find flight deals from Panama City to San Francisco

Cheapest flights from Panama City to San Francisco
Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.

Mon 10/2010:05 pmPTY - SFO

2 stops26h 40mAvianca

Mon 1/2611:15 pmSFO - PTY

1 stop12h 30mAvianca

Deal found 7/2

$497

Sun 9/143:35 pmPTY - SFO

Nonstop7h 35mUnited Airlines

Tue 9/2312:43 amSFO - PTY

1 stop11h 31mUnited Airlines

Deal found 7/2

$507

Tue 9/162:10 pmPTY - SFO

2 stops24h 11mDelta

Tue 9/239:40 amSFO - PTY

2 stops25h 15mDelta

Deal found 7/2

$512

Sat 10/113:19 pmPTY - SFO

2 stops21h 14mAmerican Airlines

Sat 10/189:45 pmSFO - PTY

2 stops14h 15mAmerican Airlines

Deal found 7/2

$538

Wed 7/303:40 pmPTY - SFO

1 stop9h 05mMultiple Airlines

Wed 8/67:20 amSFO - PTY

1 stop20h 05mMultiple Airlines

Deal found 7/2

$565

Mon 10/205:50 pmPTY - SFO

Nonstop7h 50mCopa Airlines

Sun 1/2512:42 amSFO - PTY

Nonstop7h 04mCopa Airlines

Deal found 7/2

$585

Best flights from Panama City to San Francisco
Discover carefully curated flight deals from Panama City to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 3, 2025.

Mon 10/2010:05 pmPTY - SFO

2 stops26h 40mAvianca

Mon 1/2611:15 pmSFO - PTY

1 stop12h 30mAvianca

Deal found 7/2

$497

Sun 9/143:35 pmPTY - SFO

Nonstop7h 35mUnited Airlines

Thu 9/2510:55 amSFO - PTY

Nonstop7h 15mUnited Airlines

Deal found 7/2

$507

Tue 9/162:10 pmPTY - SFO

2 stops24h 11mDelta

Tue 9/239:40 amSFO - PTY

2 stops25h 15mDelta

Deal found 7/2

$512

Sat 10/113:19 pmPTY - SFO

2 stops21h 14mAmerican Airlines

Sat 10/189:45 pmSFO - PTY

2 stops14h 15mAmerican Airlines

Deal found 7/2

$538

Wed 7/303:40 pmPTY - SFO

1 stop9h 05mMultiple Airlines

Wed 8/67:20 amSFO - PTY

1 stop20h 05mMultiple Airlines

Deal found 7/2

$565

Mon 10/205:50 pmPTY - SFO

Nonstop7h 50mCopa Airlines

Sun 1/2512:42 amSFO - PTY

Nonstop7h 04mCopa Airlines

Deal found 7/2

$585

Last-minute flights from Panama City to San Francisco
Discover last-minute flight deals from Panama City to San Francisco. Data last updated July 3, 2025 and is based on user searches.

Wed 7/93:20 amPTY - SFO

2 stops22h 35mMultiple Airlines

Sun 7/1311:59 pmSFO - PTY

3 stops22h 46mMultiple Airlines

Deal found 7/1

$811

Thu 7/103:40 pmPTY - SFO

1 stop10h 15mAvianca

Sun 7/132:20 pmSFO - PTY

1 stop18h 05mAvianca

Deal found 7/1

$534

Sun 7/133:35 pmPTY - SFO

Nonstop7h 40mUnited Airlines

Thu 7/1710:55 amSFO - PTY

Nonstop7h 15mUnited Airlines

Deal found 7/2

$759

Wed 7/303:40 pmPTY - SFO

1 stop9h 05mMultiple Airlines

Wed 8/67:20 amSFO - PTY

1 stop20h 05mMultiple Airlines

Deal found 7/2

$565

Wed 7/301:55 pmPTY - SFO

1 stop30h 52mAmerican Airlines

Wed 8/611:08 pmSFO - PTY

2 stops13h 22mAmerican Airlines

Deal found 7/2

$619

Sat 8/163:40 pmPTY - SFO

1 stop9h 05mAvianca

Sat 8/232:20 pmSFO - PTY

2 stops22h 20mAvianca

Deal found 7/2

$502

Sat 8/163:35 pmPTY - SFO

Nonstop7h 40mUnited Airlines

Fri 8/2212:43 amSFO - PTY

1 stop15h 54mUnited Airlines

Deal found 7/1

$534

One-way flights from Panama City to San Francisco
Search for one-way flight options from Panama City to San Francisco. Find affordable one-way fares based on user searches. Data last updated July 3, 2025.

Wed 9/173:40 pmPTY - SFO

1 stop9h 05mAvianca

Deal found 7/2

$286

Sat 8/93:20 amPTY - SFO

3 stops57h 05mMultiple Airlines

Deal found 7/1

$367

Tue 8/263:35 pmPTY - SFO

Nonstop7h 35mUnited Airlines

Deal found 7/2

$462

Sun 8/105:50 pmPTY - SFO

Nonstop7h 49mCopa Airlines

Deal found 7/1

$653

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Mon 10/20

10:05 pm-10:45 pm

2 stops26h 40m

San Francisco

Mon 1/26

11:15 pm-2:45 pm

1 stop12h 30m

$497

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sun 9/14

3:35 pm-9:10 pm

Nonstop7h 35m

San Francisco

Thu 9/25

10:55 am-8:10 pm

Nonstop7h 15m

$507

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 9/16

2:10 pm-12:21 pm

2 stops24h 11m

San Francisco

Tue 9/23

9:40 am-12:55 pm

2 stops25h 15m

$512

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sat 10/11

3:19 pm-10:33 am

2 stops21h 14m

San Francisco

Sat 10/18

9:45 pm-2:00 pm

2 stops14h 15m

$538

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Wed 7/30

3:40 pm-10:45 pm

1 stop9h 05m

San Francisco

Wed 8/6

7:20 am-5:25 am

1 stop20h 05m

$565

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Mon 10/20

5:50 pm-11:40 pm

Nonstop7h 50m

San Francisco

Sun 1/25

12:42 am-10:46 am

Nonstop7h 04m

$585

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Wed 9/17

3:40 pm-10:45 pm

1 stop9h 05m

$286

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sat 8/9

3:20 am-10:25 am

3 stops57h 05m

$367

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 8/26

3:35 pm-9:10 pm

Nonstop7h 35m

$462

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sun 8/10

5:50 pm-11:39 pm

Nonstop7h 49m

$653

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/2

The best insider tips for Panama City to San Francisco flights

Cheapflights partnered with top experts to bring you the best recommendations for your Panama City to San Francisco trip

Airports

PTY

For US-bound flights, expect two security checks at PTY, with the second at the gate. Allow extra time for this process.

SFO

Use BART for affordable travel from SFO to downtown San Francisco. The trip takes about 40 minutes and starts from the Garage G/Bart station.

Our travel experts

Taryn White

Expert on PTY

Harriet Baskas

Expert on SFO

Best time to book a flight from Panama City to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to San Francisco

How far ahead should I book a flight from Panama City to San Francisco?

The price you pay for your flight from Panama City to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 64 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Panama City to San Francisco (average of $276). Flying from Panama City to San Francisco in June is currently the most expensive (average of $360). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SFO?

Unlike in the afternoon, when flights are generally more expensive, you can save up to 38% on flights from Panama City to San Francisco by exploring options for tickets in the evening.

Weekly flight availability from Panama City to San Francisco

The most flights from PTY to SFO are scheduled on a Monday (4 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (4 on average).

Reviews of airlines servicing San Francisco

Read through reviews of airlines operating flights from Panama City to San Francisco, such as Delta, Copa Airlines, and United Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,982 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta

8.0

Very good

7,982 reviews

Delta

8.0

Very good

7,982 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Copa Airlines

7.5

Good

1,467 reviews

Delta

8.0

Very good

7,982 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

United Airlines

7.4

Good

8,861 reviews

Delta

8.0

Very good

7,982 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,982 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Avianca

6.7

Okay

2,363 reviews

Delta

8.0

Very good

7,982 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

What airports do I use to fly from Panama City to San Francisco?
If you book a flight from Panama City to San Francisco, you will be flying from Tocumen Intl to San Francisco. Flights to San Francisco (SFO) from Panama City Tocumen Intl (PTY) take 7h 35m for a nonstop flight. There are 4 flights from Tocumen Intl to San Francisco per day from 3 airlines.
How popular is this Panama City to San Francisco flight route?
The Panama City Tocumen Intl to San Francisco flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
What are the cheapest airlines flying from Panama City to San Francisco round-trip?
Cheapflights users have booked flights from Panama City to San Francisco round-trip from $497. Other airlines that can offer you cheap pricing are United Airlines, from $507, and Delta, from $512. Avianca is priced at 20% lower than the current average price of a flight leaving 3 months from now.
What are the cheapest airlines to fly from Panama City to San Francisco one-way?
The cheapest airlines for a one-way flight from Panama City to San Francisco are Avianca ($286), United Airlines ($462), and Copa Airlines ($653).
What are the cheapest flights from Panama City to San Francisco?
The cheapest flight price from Panama City to San Francisco is $306. On average you can expect to pay $846. The most popular route, (Panama City Tocumen Intl - San Francisco), can usually be booked for $495.
Can I find deals for flights from Panama City to San Francisco that include hotel bookings?
Yes. In addition to deals on Panama City to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Francisco.
Can I find deals for business class flights from Panama City to San Francisco?
Yes. Cheapflights offers flight deals from Panama City to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City to San Francisco?
Currently, January is the cheapest month in which you can book a flight from Panama City to San Francisco (average of $276). Flying from Panama City to San Francisco in June is currently the most expensive (average of $360). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Roseville

Mountain View

South San Francisco

Livermore

Santa Cruz

Turlock

Manteca

Watsonville

Antioch

Hollister

Newark

Alameda

Hayward

Milpitas

Sunnyvale

Daly City

Campbell

Foster City

Capitola

Richmond

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from Panama City to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
Avianca	Cheapest$474	Average$615	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$506	Average$644	FlexibilityNo cancel fee	On-time69%
Copa Airlines	Cheapest$506	Average$633	FlexibilityNo cancel fee	On-time70%

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$286+ Cheap flights from Panama City (PTY) to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/17. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to San Francisco with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Panama City Tocumen Intl to San Francisco are usually found in August or June, booked 65 days in advance, depart on a Thursday or Monday and return on a Tuesday

Cheap flight deals from Panama City to San Francisco

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Find flight deals from Panama City to San Francisco

Cheapest flights from Panama City to San FranciscoExplore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.

Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.

The best insider tips for Panama City to San Francisco flights

Cheapflights partnered with top experts to bring you the best recommendations for your Panama City to San Francisco trip

Airports

PTY

SFO

Our travel experts

Best time to book a flight from Panama City to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama City with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Panama City to San Francisco

How far ahead should I book a flight from Panama City to San Francisco?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to San Francisco. Price data was last updated on June 27, 2025.

What is the cheapest month to book a flight from Panama City to San Francisco?

What is the cheapest time of day to fly from PTY to SFO?

Find hourly flight availability from Panama City to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 3, 2025.

Weekly flight availability from Panama City to San Francisco

Reviews of airlines servicing San Francisco

Read through reviews of airlines operating flights from Panama City to San Francisco, such as Delta, Copa Airlines, and United Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Panama City to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airports do I use to fly from Panama City to San Francisco?

How popular is this Panama City to San Francisco flight route?

What are the cheapest airlines flying from Panama City to San Francisco round-trip?

What are the cheapest airlines to fly from Panama City to San Francisco one-way?

What are the cheapest flights from Panama City to San Francisco?

Can I find deals for flights from Panama City to San Francisco that include hotel bookings?

How can I find direct flights from Panama City to San Francisco?

Can I find deals for business class flights from Panama City to San Francisco?

What is the cheapest month to book a flight from Panama City to San Francisco?

Traveling to a place near Panama City?

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Alternative routes for Panama City to San Francisco

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Top 3 airlines flying from Panama City to San Francisco

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Cheapest flights from Panama City to San Francisco
Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.