$335+ Cheap flights from Santo Domingo (SDQ) to Panama City (PTY)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/1. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — PTY
Nov 23 — Nov 301
Round-trip
1 adult, Economy
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Find cheap flights from Santo Domingo to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Santo Domingo Las Americas to Panama City Tocumen Intl are usually found in January or February, booked 90 days in advance, depart on a Thursday or Wednesday and return on a Friday
Cheap flight deals from Santo Domingo to Panama City
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Best
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Cheapest flights from Santo Domingo to Panama CityExplore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 24, 2026.
Explore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 24, 2026.
This Avianca deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/712:45 pm -
1 stop5h 30m
Sat 11/72:30 am -
1 stop8h 20m
Deal found 10/24![Avianca logo]()
$481
This Avianca deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/712:45 pm -
1 stop13h 35m
Mon 11/96:10 pm -
1 stop16h 40m
Deal found 10/20![Avianca logo]()
$482
This Copa Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/17:06 pm -
Nonstop2h 34m
Sun 11/89:42 am -
Nonstop2h 28m
Deal found 10/21![Copa Airlines logo]()
$493
This Copa Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/278:55 am -
Nonstop2h 35m
Mon 11/3010:41 pm -
Nonstop2h 27m
Deal found 10/20![Copa Airlines logo]()
$505
This FlightHub deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/612:45 pm -
1 stop5h 30m
Sun 11/810:05 am -
1 stop24h 45m
Deal found 10/20![Avianca logo]()
$513
This Avianca deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:45 pm -
1 stop7h 35m
Mon 11/306:10 pm -
1 stop16h 40m
Deal found 10/20![Avianca logo]()
$514
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/312:45 pm -
Nonstop2h 36m
Mon 11/1610:41 pm -
Nonstop2h 27m
Deal found 10/23![Copa Airlines logo]()
$544
This FlightHub deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/206:45 pm -
1 stop21h 30m
Sat 11/216:10 pm -
1 stop22h 40m
Deal found 10/20![Avianca logo]()
$545
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/27:06 pm -
Nonstop2h 34m
Mon 11/1610:41 pm -
Nonstop2h 27m
Deal found 10/23![Copa Airlines logo]()
$546
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2912:12 pm -
Nonstop2h 33m
Mon 11/210:41 pm -
Nonstop2h 27m
Deal found 10/20![Copa Airlines logo]()
$547
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:55 am -
Nonstop2h 33m
Mon 11/1610:41 pm -
Nonstop2h 27m
Deal found 10/23![Copa Airlines logo]()
$548
This Copa Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/712:10 pm -
Nonstop2h 35m
Mon 11/99:42 am -
Nonstop2h 28m
Deal found 10/21![Copa Airlines logo]()
$574
Best flights from Santo Domingo to Panama CityDiscover carefully curated flight deals from Santo Domingo to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 24, 2026.
Discover carefully curated flight deals from Santo Domingo to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 24, 2026.
This Copa Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/2112:06 pm -
Nonstop2h 39m
Sun 1/247:26 pm -
Nonstop2h 28m
Deal found 10/19![Copa Airlines logo]()
$493
This Copa Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:06 pm -
Nonstop2h 34m
Tue 11/178:15 am -
Nonstop2h 30m
Deal found 10/24![Copa Airlines logo]()
$493
This Copa Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2512:05 pm -
Nonstop2h 40m
Sun 2/2812:44 pm -
Nonstop2h 24m
Deal found 10/23![Copa Airlines logo]()
$493
This Copa Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1912:10 pm -
Nonstop2h 35m
Mon 11/238:15 am -
Nonstop2h 30m
Deal found 10/21![Copa Airlines logo]()
$493
This Copa Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/192:20 pm -
Nonstop2h 34m
Thu 11/267:40 am -
Nonstop2h 27m
Deal found 10/20![Copa Airlines logo]()
$493
This Copa Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/218:52 am -
Nonstop2h 38m
Mon 1/259:42 am -
Nonstop2h 26m
Deal found 10/24![Copa Airlines logo]()
$493
This Copa Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/195:50 am -
Nonstop2h 38m
Fri 1/298:15 am -
Nonstop2h 27m
Deal found 10/22![Copa Airlines logo]()
$493
This Copa Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/162:14 pm -
Nonstop2h 44m
Sat 1/27:26 pm -
Nonstop2h 28m
Deal found 10/22![Copa Airlines logo]()
$493
This Copa Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:06 pm -
Nonstop2h 34m
Thu 11/267:40 am -
Nonstop2h 27m
Deal found 10/21![Copa Airlines logo]()
$493
This Copa Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/108:55 am -
Nonstop2h 35m
Mon 11/1610:41 pm -
Nonstop2h 27m
Deal found 10/20![Copa Airlines logo]()
$493
This Copa Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/202:37 pm -
Nonstop2h 38m
Thu 3/258:12 am -
Nonstop2h 24m
Deal found 10/24![Copa Airlines logo]()
$493
This Copa Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1012:43 pm -
Nonstop2h 38m
Mon 12/147:26 pm -
Nonstop2h 32m
Deal found 10/23![Copa Airlines logo]()
$493
Last-minute flights from Santo Domingo to Panama CityDiscover last-minute flight deals from Santo Domingo to Panama City. Data last updated October 24, 2026 and is based on user searches.
Discover last-minute flight deals from Santo Domingo to Panama City. Data last updated October 24, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2912:12 pm -
Nonstop2h 33m
Mon 11/210:41 pm -
Nonstop2h 27m
Deal found 10/20![Copa Airlines logo]()
$547
This Copa Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/17:06 pm -
Nonstop2h 34m
Sun 11/89:42 am -
Nonstop2h 28m
Deal found 10/21![Copa Airlines logo]()
$493
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:55 am -
Nonstop2h 33m
Mon 11/1610:41 pm -
Nonstop2h 27m
Deal found 10/23![Copa Airlines logo]()
$548
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/27:06 pm -
Nonstop2h 34m
Mon 11/1610:41 pm -
Nonstop2h 27m
Deal found 10/23![Copa Airlines logo]()
$546
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/312:45 pm -
Nonstop2h 36m
Mon 11/1610:41 pm -
Nonstop2h 27m
Deal found 10/23![Copa Airlines logo]()
$544
This FlightHub deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/612:45 pm -
1 stop5h 30m
Sun 11/810:05 am -
1 stop24h 45m
Deal found 10/20![Avianca logo]()
$513
This Avianca deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/712:45 pm -
1 stop5h 30m
Sat 11/72:30 am -
1 stop8h 20m
Deal found 10/24![Avianca logo]()
$481
This Avianca deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/712:45 pm -
1 stop5h 30m
Tue 11/106:10 pm -
1 stop16h 40m
Deal found 10/20![Avianca logo]()
$482
This Copa Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/712:10 pm -
Nonstop2h 35m
Mon 11/99:42 am -
Nonstop2h 28m
Deal found 10/21![Copa Airlines logo]()
$574
This Avianca deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:45 pm -
1 stop7h 35m
Mon 11/306:10 pm -
1 stop16h 40m
Deal found 10/20![Avianca logo]()
$514
This FlightHub deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/206:45 pm -
1 stop21h 30m
Sat 11/216:10 pm -
1 stop22h 40m
Deal found 10/20![Avianca logo]()
$545
This Copa Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/278:55 am -
Nonstop2h 35m
Mon 11/3010:41 pm -
Nonstop2h 27m
Deal found 10/20![Copa Airlines logo]()
$505
One-way flights from Santo Domingo to Panama CitySearch for one-way flight options from Santo Domingo to Panama City. Find affordable one-way fares based on user searches. Data last updated October 24, 2026.
Search for one-way flight options from Santo Domingo to Panama City. Find affordable one-way fares based on user searches. Data last updated October 24, 2026.
This Jetabroad deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Jetabroad is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/112:45 pm -
1 stop5h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![Avianca logo]()
$335
This Avianca deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:45 pm -
1 stop7h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Avianca logo]()
$339
This Super.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:45 pm -
1 stop7h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Avianca logo]()
$346
This Super.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/512:45 pm -
1 stop5h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Avianca logo]()
$350
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:45 pm -
1 stop15h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Avianca logo]()
$352
This Jetabroad deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Jetabroad is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:45 pm -
1 stop7h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Avianca logo]()
$354
This Avianca deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:45 pm -
1 stop7h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Avianca logo]()
$361
This Avianca deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:45 pm -
1 stop21h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Avianca logo]()
$367
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:05 pm -
1 stop21h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Multiple Airlines logo]()
$402
This Mytrip deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/127:35 am -
2 stops18h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Multiple Airlines logo]()
$407
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:00 pm -
2 stops19h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Multiple Airlines logo]()
$426
This Avianca deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/276:45 pm -
1 stop7h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Avianca logo]()
$440
Find flight deals from Santo Domingo to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $481 (Avianca) |
One-way from | $335 (Jetabroad) |
Popular in | March |
Cheapest in | January |
Average price | $575 |
Good round-trip deal | $394 or less |
Good one-way deal | $270 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Santo Domingo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 24, 2026.
Use the filters below to find and compare flights from Santo Domingo to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Santo DomingoPanama City
SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl
SDQPTY
Santo Domingo Las Americas
Wed 11/11
6:45 pm-1:20 am
1 stop7h 35m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:30 am
Nonstop0h 00m
$361
Santo DomingoPanama City
SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl
SDQPTY
Santo Domingo Las Americas
Sun 12/6
12:45 pm-5:15 pm
1 stop5h 30m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:30 am
Nonstop0h 00m
$367
Santo DomingoPanama City
SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl
SDQPTY
Santo Domingo Las Americas
Sat 10/31
12:45 pm-9:10 am
1 stop21h 25m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:30 am
Nonstop0h 00m
$367
Santo DomingoPanama City
SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl
SDQPTY
Santo Domingo Las Americas
Mon 12/21
7:30 am-1:20 am
2 stops18h 50m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:30 am
Nonstop0h 00m
$444
Santo DomingoPanama City
SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl
SDQPTY
Santo Domingo Las Americas
Thu 1/21
12:06 pm-1:45 pm
Nonstop2h 39m
Panama City Tocumen Intl
Sun 1/24
7:26 pm-10:54 pm
Nonstop2h 28m
$493
Santo DomingoPanama City
SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl
SDQPTY
Santo Domingo Las Americas
Fri 11/13
7:06 pm-8:40 pm
Nonstop2h 34m
Panama City Tocumen Intl
Tue 11/17
8:15 am-11:45 am
Nonstop2h 30m
$493
Santo DomingoPanama City
SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl
SDQPTY
Santo Domingo Las Americas
Thu 2/25
12:05 pm-1:45 pm
Nonstop2h 40m
Panama City Tocumen Intl
Sun 2/28
12:44 pm-4:08 pm
Nonstop2h 24m
$493
Santo DomingoPanama City
SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl
SDQPTY
Santo Domingo Las Americas
Thu 11/19
12:10 pm-1:45 pm
Nonstop2h 35m
Panama City Tocumen Intl
Mon 11/23
8:15 am-11:45 am
Nonstop2h 30m
$493
Santo DomingoPanama City
SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl
SDQPTY
Santo Domingo Las Americas
Thu 11/19
2:20 pm-3:54 pm
Nonstop2h 34m
Panama City Tocumen Intl
Thu 11/26
7:40 am-11:07 am
Nonstop2h 27m
$493
Santo DomingoPanama City
SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl
SDQPTY
Santo Domingo Las Americas
Thu 1/21
8:52 am-10:30 am
Nonstop2h 38m
Panama City Tocumen Intl
Mon 1/25
9:42 am-1:08 pm
Nonstop2h 26m
$493
Showing 1-10 of 24 resultsSorted by cheapest first
Compare providers for flights from Santo Domingo to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santo Domingo to Panama City in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Santo Domingo-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santo Domingo-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santo Domingo-Panama City flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santo Domingo-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santo Domingo to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Santo Domingo with our price prediction graph.
SDQ-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Santo Domingo to Panama City
Prices
Delays
How far ahead should I book a flight from Santo Domingo to Panama City?
The best time to book flights from Santo Domingo to Panama City is 89 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Santo Domingo to Panama City?
Currently, January is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of $524). Flying from Santo Domingo to Panama City in March is currently the most expensive (average of $618). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SDQ to PTY?
Find hourly flight availability from Santo Domingo to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 24, 2026.
One of the essential ways to save on airfare from Santo Domingo to Panama City is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the afternoon could potentially save you up to 12% on airfare.
What is the cheapest day to fly from Santo Domingo to Panama City?
Use this chart to determine the cheapest time to fly round-trip from Santo Domingo to Panama City. Price data was last updated on October 17, 2026.
Travelers seeking maximum savings on their Santo Domingo to Panama City flight should consider departing on Thursday afternoons when fares are most often at their lowest. Saturday at noon flights should be avoided if possible as fares are typically the most expensive at this time.
How often are flights from Santo Domingo to Panama City delayed?
About 5% of weekly flights between Santo Domingo and Panama City have experienced delays in the past year, with the average delay time being 109 minutes.
What is the most punctual flight time for Santo Domingo to Panama City flights?
Historically, flights departing at night are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Saturday tends to have the lowest number of delays on this route, whereas Thursday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Santo Domingo to Panama City flights?
Over the last year, Copa Airlines have had the lowest number of delays on this route, with just 5% of flights being delayed.
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated October 24, 2026.
Read through reviews of airlines operating flights from Santo Domingo to Panama City, such as Copa Airlines and Avianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Comfort
7.4
Boarding
7.8
Entertainment
6.9
Overall
7.6
Crew
8.1
Reviews
1 / 20
2.0
MediocreAnonymous,Oct 2026
BOS - PTY
Food
7.0
Comfort
7.4
Boarding
7.8
Entertainment
6.9
Overall
7.6
Crew
8.1
Reviews
1 / 20
2.0
MediocreAnonymous,Oct 2026
BOS - PTY
Food
7.0
Comfort
7.4
Boarding
7.8
Entertainment
6.9
Overall
7.6
Crew
8.1
Reviews
1 / 20
2.0
MediocreAnonymous,Oct 2026
BOS - PTY
Related info for your journey
Find useful and relevant information for your journey from Santo Domingo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Santo Domingo and Panama City flights
Browse other Santo Domingo and Panama City flight options. Last updated on October 24, 2026.
Other flights from Santo Domingo
Browse through other flights departing from Santo Domingo. Flights are based on user searches made on Cheapflights and were last updated on October 24, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 24, 2026.
Popular flight searches
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Top 2 airlines flying from Santo Domingo to Panama City
Discover the top 2 airlines that operate flights from Santo Domingo to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$259 | Average$564 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$440 | Average$620 | FlexibilityNo cancel fee | On-time70% |