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Panama City

$255+ Cheap flights from Santo Domingo (SDQ) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/14. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — PTY
Aug 26 — Sep 21
Wed 8/26
Wed 9/2
1 adult, Economy
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Cheapflights Tip: The best prices from Santo Domingo Las Americas to Panama City Tocumen Intl are usually found in January or February, booked 78 days in advance, depart on a Thursday or Tuesday and return on a Friday

Cheap flight deals from Santo Domingo to Panama City

Cheapest flights from Santo Domingo to Panama City
Explore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 27, 2026.

This Super.com deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/1612:45 pm
SDQ
-
PTY
1 stop12h 50m
Avianca
Mon 8/1710:10 am
PTY
-
SDQ
1 stop6h 45m
Avianca
Deal found 7/23$551
This Super.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/412:45 pm
SDQ
-
PTY
1 stop12h 50m
Avianca
Sun 8/94:25 am
PTY
-
SDQ
1 stop12h 30m
Avianca
Deal found 7/22$552
This Mytrip deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:50 pm
SDQ
-
PTY
1 stop15h 25m
Multiple Airlines
Sat 9/194:25 am
PTY
-
SDQ
2 stops13h 53m
Multiple Airlines
Deal found 7/24$554
This Mytrip deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/46:50 pm
SDQ
-
PTY
1 stop15h 25m
Multiple Airlines
Sat 9/124:25 am
PTY
-
SDQ
2 stops13h 53m
Multiple Airlines
Deal found 7/27$558
This FlightHub deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/46:50 pm
SDQ
-
PTY
1 stop6h 45m
Avianca
Mon 8/104:25 am
PTY
-
SDQ
1 stop12h 30m
Avianca
Deal found 7/25$559
This FlightHub deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/612:45 pm
SDQ
-
PTY
1 stop12h 50m
Avianca
Fri 8/1410:10 am
PTY
-
SDQ
1 stop6h 45m
Avianca
Deal found 7/23$560
This Justfly.com deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2312:45 pm
SDQ
-
PTY
1 stop12h 50m
Avianca
Sun 9/274:25 am
PTY
-
SDQ
1 stop6h 25m
Avianca
Deal found 7/23$561
This FlightHub deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/46:50 pm
SDQ
-
PTY
1 stop6h 45m
Avianca
Sun 9/134:25 am
PTY
-
SDQ
1 stop6h 25m
Avianca
Deal found 7/27$562
This FlightHub deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2012:45 pm
SDQ
-
PTY
1 stop12h 50m
Avianca
Tue 9/224:25 am
PTY
-
SDQ
1 stop12h 30m
Avianca
Deal found 7/26$563
This Super.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/312:45 pm
SDQ
-
PTY
1 stop12h 50m
Avianca
Fri 8/1410:10 am
PTY
-
SDQ
1 stop6h 45m
Avianca
Deal found 7/22$564
This FlightHub deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:50 pm
SDQ
-
PTY
1 stop6h 45m
Avianca
Tue 8/255:55 pm
PTY
-
SDQ
1 stop16h 55m
Avianca
Deal found 7/26$565
This FlightHub deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/216:50 pm
SDQ
-
PTY
1 stop15h 25m
Avianca
Wed 9/234:25 am
PTY
-
SDQ
1 stop12h 30m
Avianca
Deal found 7/27$566

Find flight deals from Santo Domingo to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$551
(Super.com)

One-way from

$255
(Kiwi.com)

Popular in

May

Cheapest in

January

Average price

$583

Good round-trip deal

$408 or less

Good one-way deal

$233 or less
Provider with most accurate pricing for Santo Domingo Las Americas-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santo Domingo Las Americas-Panama City Tocumen Intl flights.
Search Deals
From Santo Domingo Las Americas to Panama City Tocumen Intl
Search Deals
One-way flight from Santo Domingo Las Americas to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($26 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($5 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals
Price to beat on a round-trip flight from Santo Domingo Las Americas to Panama City Tocumen Intl.
Search Deals
Price to beat on a one-way flight from Santo Domingo Las Americas to Panama City Tocumen Intl.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 27, 2026.
Use the filters below to find and compare flights from Santo Domingo to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 10/27

5:55 am-7:28 am

Nonstop2h 33m

Panama City Tocumen Intl

Sun 11/1

9:42 am-1:10 pm

Nonstop2h 28m

$630

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sat 10/3

6:41 pm-8:14 pm

Nonstop2h 33m

Panama City Tocumen Intl

Sat 10/17

10:55 pm-2:25 am

Nonstop2h 30m

$630

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 9/15

12:42 pm-2:15 pm

Nonstop2h 33m

Panama City Tocumen Intl

Wed 9/30

9:42 am-1:13 pm

Nonstop2h 31m

$630

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 11/6

7:06 pm-8:40 pm

Nonstop2h 34m

Panama City Tocumen Intl

Mon 11/9

10:41 pm-2:08 am

Nonstop2h 27m

$630

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sat 9/12

6:41 pm-8:14 pm

Nonstop2h 33m

Panama City Tocumen Intl

Sat 9/19

7:26 pm-10:56 pm

Nonstop2h 30m

$630

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Wed 10/28

2:25 pm-3:58 pm

Nonstop2h 33m

Panama City Tocumen Intl

Sun 11/1

9:42 am-1:10 pm

Nonstop2h 28m

$630

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Wed 9/23

12:42 pm-2:15 pm

Nonstop2h 33m

Panama City Tocumen Intl

Sun 9/27

12:44 pm-4:15 pm

Nonstop2h 31m

$630

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Wed 8/19

2:17 pm-3:49 pm

Nonstop2h 32m

Panama City Tocumen Intl

Mon 8/31

9:42 am-1:13 pm

Nonstop2h 31m

$630
Cheapest one-way

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sun 8/30

4:35 pm-9:15 am

2 stops17h 40m

$349

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Thu 10/8

6:50 pm-12:35 am

1 stop6h 45m

$379

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/24

Showing 1-10 of 16 resultsSorted by cheapest first
1
2
  • Most accurate provider: When it comes to deals on Santo Domingo-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santo Domingo-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santo Domingo-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santo Domingo-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santo Domingo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Panama City

How far ahead should I book a flight from Santo Domingo to Panama City?

The best time to book flights from Santo Domingo to Panama City is 77 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santo Domingo to Panama City?

Currently, January is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of $524). Flying from Santo Domingo to Panama City in May is currently the most expensive (average of $608). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDQ to PTY?

Find hourly flight availability from Santo Domingo to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 27, 2026.

One of the essential ways to save on airfare from Santo Domingo to Panama City is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight in the afternoon could potentially save you up to 12% on airfare.

What is the cheapest day to fly from Santo Domingo to Panama City?

Use this chart to determine the cheapest time to fly round-trip from Santo Domingo to Panama City. Price data was last updated on July 18, 2026.

Travelers seeking maximum savings on their Santo Domingo to Panama City flight should consider departing on Monday evenings when fares are most often at their lowest. Thursday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Santo Domingo to Panama City?

Airfare is typical for this route at the moment.

Santo Domingo to Panama City flights typically cost between $502 and $630 in August.
The cheapest round-trip price found within the last 5 days was $551 on Avianca (Aug 16-Aug 17).

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated July 27, 2026.
Read through reviews of airlines operating flights from Santo Domingo to Panama City, such as Copa Airlines and Avianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,561 reviews

Entertainment

6.8

Overall

7.6

Crew

8.1

Comfort

7.4

Boarding

7.8

Food

6.9

Reviews

1 / 20
2.0
Mediocre

Anonymous,Jul 2026

BOS - PTY

Airline was delayed 1 hour, that made my layover flight be missed, gave wrong information about gates, they closed the gates in my face, rebooked me, and had business class, and rebooked me not business class
Copa Airlines
7.6
Good
1,561 reviews
Copa Airlines
7.6
Good
1,561 reviews

Entertainment

6.8

Overall

7.6

Crew

8.1

Comfort

7.4

Boarding

7.8

Food

6.9

Reviews

1 / 20
2.0
Mediocre

Anonymous,Jul 2026

BOS - PTY

Airline was delayed 1 hour, that made my layover flight be missed, gave wrong information about gates, they closed the gates in my face, rebooked me, and had business class, and rebooked me not business class
Avianca
6.5
Okay
2,522 reviews
Copa Airlines
7.6
Good
1,561 reviews

Entertainment

6.8

Overall

7.6

Crew

8.1

Comfort

7.4

Boarding

7.8

Food

6.9

Reviews

1 / 20
2.0
Mediocre

Anonymous,Jul 2026

BOS - PTY

Airline was delayed 1 hour, that made my layover flight be missed, gave wrong information about gates, they closed the gates in my face, rebooked me, and had business class, and rebooked me not business class

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Santo Domingo to Panama City?

    If you wish to fly to Panama City from Santo Domingo, then you need to book flights from Santo Domingo Las Americas to Panama City Tocumen Intl. There are 8 flights from Las Americas (SDQ) to Tocumen Intl (PTY) per day to choose from. Flights to Panama City from Las Americas are available from 2 different airlines, which means you should have some options if you want to compare airfare deals. 2h 32m is how long a nonstop flight from Santo Domingo to Panama City Tocumen Intl typically takes.

  • How popular is this Santo Domingo to Panama City flight route?

    This flight path from Santo Domingo Las Americas to Panama City Tocumen Intl was viewed by 15 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Santo Domingo to Panama City?

    Airlines like Avianca fly from Santo Domingo to Panama City in about 12h 50m. The time it takes to get you to your destination can typically vary by up to . There are 917 mi between Santo Domingo and Panama City.

  • What are the cheapest airlines flying from Santo Domingo to Panama City round-trip?

    Cheapflights users have booked flights from Santo Domingo to Panama City round-trip from $259. Another airline that can offer you cheap pricing is Copa Airlines. Avianca is 53% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the most reliable airlines from Santo Domingo to Panama City?

    Consider Air France (97%), KLM (96%) or Turkish Airlines (95%) when booking your flight. These represent the most reliable airlines when flying from Santo Domingo to Panama City.

  • What are the cheapest flights from Santo Domingo to Panama City?

    Looking at all options, your cheapest flight can be booked for $160. While the most popular route (Santo Domingo Las Americas - Panama City Tocumen Intl) can be booked for $578 on average, our data indicates $670 when flying from Santo Domingo to Panama City.

  • Can I find deals for flights from Santo Domingo to Panama City that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Panama City.

  • Can I find deals for business class flights from Santo Domingo to Panama City?

    Yes. Cheapflights offers flight deals from Santo Domingo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Panama City?

    Currently, January is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of $524). Flying from Santo Domingo to Panama City in May is currently the most expensive (average of $608). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Santo Domingo to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
Punta Cana to Panama City flights

Top 2 airlines flying from Santo Domingo to Panama City

Discover the top 2 airlines that operate flights from Santo Domingo to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$259Average$476FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$429Average$576FlexibilityNo cancel feeOn-time70%

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