$304+ Cheap flights from Santo Domingo (SDQ) to Panama City (PTY)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/18. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — PTY
Oct 10 — Oct 171
Round-trip
1 adult, Economy
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Find cheap flights from Santo Domingo to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Santo Domingo Las Americas to Panama City Tocumen Intl are usually found in January or February, booked 90 days in advance, depart on a Thursday or Tuesday and return on a Friday
Cheap flight deals from Santo Domingo to Panama City
Cheapest
Best
Last-minute
One-way
Cheapest flights from Santo Domingo to Panama CityExplore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
Explore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/214:00 pm -
2 stops11h 10m
Tue 11/2411:30 am -
1 stop10h 16m
Deal found 9/7![Multiple Airlines logo]()
$557
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/259:30 am -
1 stop11h 50m
Wed 12/97:55 am -
1 stop7h 21m
Deal found 9/7![Multiple Airlines logo]()
$561
This Avianca deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:45 pm -
1 stop7h 35m
Mon 11/910:05 am -
1 stop6h 45m
Deal found 9/6![Avianca logo]()
$571
This Avianca deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:45 pm -
1 stop7h 35m
Sun 11/16:10 pm -
1 stop16h 40m
Deal found 9/7![Avianca logo]()
$572
This Avianca deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1612:45 pm -
1 stop12h 50m
Fri 9/184:25 am -
1 stop6h 25m
Deal found 9/8![Avianca logo]()
$573
This Avianca deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:50 pm -
1 stop15h 25m
Thu 10/810:10 am -
1 stop6h 45m
Deal found 9/7![Avianca logo]()
$590
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2012:45 pm -
1 stop5h 30m
Sun 11/2210:05 am -
1 stop6h 45m
Deal found 9/7![Avianca logo]()
$595
This FlightHub deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:50 pm -
1 stop23h 10m
Sun 9/275:55 pm -
1 stop23h 00m
Deal found 9/5![Avianca logo]()
$603
This Copa Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/275:55 am -
Nonstop2h 33m
Sun 11/19:42 am -
Nonstop2h 28m
Deal found 9/8![Copa Airlines logo]()
$607
This Avianca deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/106:50 pm -
1 stop6h 45m
Sat 10/1010:10 am -
1 stop6h 45m
Deal found 9/6![Avianca logo]()
$610
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/312:45 pm -
Nonstop2h 36m
Sat 11/710:34 am -
1 stop11h 12m
Deal found 9/6![Multiple Airlines logo]()
$615
This FlightHub deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:45 pm -
1 stop7h 35m
Mon 11/99:42 am -
Nonstop2h 28m
Deal found 9/8![Multiple Airlines logo]()
$616
Best flights from Santo Domingo to Panama CityDiscover carefully curated flight deals from Santo Domingo to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
Discover carefully curated flight deals from Santo Domingo to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
This Copa Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/232:16 pm -
Nonstop2h 33m
Wed 10/289:42 am -
Nonstop2h 30m
Deal found 9/9![Copa Airlines logo]()
$630
This Copa Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:06 am -
Nonstop2h 33m
Sun 11/19:42 am -
Nonstop2h 28m
Deal found 9/9![Copa Airlines logo]()
$630
This Copa Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:06 am -
Nonstop2h 33m
Sun 9/2712:44 pm -
Nonstop2h 31m
Deal found 9/5![Copa Airlines logo]()
$654
This Copa Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:06 pm -
Nonstop2h 34m
Mon 11/910:41 pm -
Nonstop2h 27m
Deal found 9/9![Copa Airlines logo]()
$654
This Copa Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:41 pm -
Nonstop2h 33m
Sat 10/178:11 am -
Nonstop2h 30m
Deal found 9/7![Copa Airlines logo]()
$654
This Copa Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/105:53 am -
Nonstop2h 35m
Thu 12/179:42 am -
Nonstop2h 32m
Deal found 9/6![Copa Airlines logo]()
$654
This Copa Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:41 pm -
Nonstop2h 33m
Wed 9/3012:44 pm -
Nonstop2h 31m
Deal found 9/5![Copa Airlines logo]()
$654
This Copa Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:41 pm -
Nonstop2h 33m
Thu 10/227:24 am -
Nonstop2h 30m
Deal found 9/9![Copa Airlines logo]()
$654
This Copa Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:41 pm -
Nonstop2h 33m
Sun 9/279:42 am -
Nonstop2h 31m
Deal found 9/8![Copa Airlines logo]()
$654
Last-minute flights from Santo Domingo to Panama CityDiscover last-minute flight deals from Santo Domingo to Panama City. Data last updated September 10, 2026 and is based on user searches.
Discover last-minute flight deals from Santo Domingo to Panama City. Data last updated September 10, 2026 and is based on user searches.
This Avianca deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/106:50 pm -
1 stop6h 45m
Sat 10/1010:10 am -
1 stop6h 45m
Deal found 9/6![Avianca logo]()
$610
This Avianca deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1612:45 pm -
1 stop12h 50m
Fri 9/184:25 am -
1 stop6h 25m
Deal found 9/8![Avianca logo]()
$573
This Cheapflightsfares deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2012:45 pm -
1 stop12h 50m
Tue 9/2210:10 am -
1 stop6h 45m
Deal found 9/8![Avianca logo]()
$628
This Avianca deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:50 pm -
1 stop15h 25m
Thu 10/810:10 am -
1 stop6h 45m
Deal found 9/7![Avianca logo]()
$590
This FlightHub deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:50 pm -
1 stop23h 10m
Sun 9/275:55 pm -
1 stop23h 00m
Deal found 9/5![Avianca logo]()
$603
This Avianca deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:50 pm -
1 stop6h 45m
Sun 9/274:25 am -
1 stop12h 30m
Deal found 9/6![Avianca logo]()
$639
This Copa Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:06 am -
Nonstop2h 33m
Thu 10/87:26 pm -
Nonstop2h 30m
Deal found 9/7![Copa Airlines logo]()
$654
This Mytrip deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:45 am -
2 stops17h 50m
Fri 10/164:25 am -
2 stops18h 32m
Deal found 9/7![Multiple Airlines logo]()
$648
This Avianca deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:50 pm -
1 stop6h 45m
Thu 10/224:25 am -
1 stop12h 30m
Deal found 9/5![Avianca logo]()
$571
This Copa Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/248:47 am -
Nonstop2h 33m
Wed 10/287:39 am -
Nonstop2h 30m
Deal found 9/7![Copa Airlines logo]()
$630
This Copa Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/275:55 am -
Nonstop2h 33m
Sun 11/19:42 am -
Nonstop2h 28m
Deal found 9/8![Copa Airlines logo]()
$607
This Avianca deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:45 pm -
1 stop7h 35m
Sun 11/16:10 pm -
1 stop16h 40m
Deal found 9/7![Avianca logo]()
$572
One-way flights from Santo Domingo to Panama CitySearch for one-way flight options from Santo Domingo to Panama City. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.
Search for one-way flight options from Santo Domingo to Panama City. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.
This Super.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:50 pm -
1 stop15h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Avianca logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/223:58 pm -
1 stop19h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$313
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/292:10 pm -
1 stop6h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$314
This Jetabroad deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Jetabroad is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/412:45 pm -
1 stop12h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/5![Avianca logo]()
$317
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:05 pm -
1 stop26h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$330
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:45 am -
1 stop11h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$333
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:45 am -
1 stop13h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$340
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/274:35 pm -
1 stop28h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$346
This Avianca deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/1212:45 pm -
1 stop5h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Avianca logo]()
$360
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/184:35 pm -
1 stop28h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$361
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:35 am -
2 stops25h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Multiple Airlines logo]()
$382
Find flight deals from Santo Domingo to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $557 (Kiwi.com) |
One-way from | $288 (Copa Airlines) |
Popular in | August |
Cheapest in | January |
Average price | $572 |
Good round-trip deal | $369 or less |
Good one-way deal | $298 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Santo Domingo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
Use the filters below to find and compare flights from Santo Domingo to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Santo DomingoPanama City
SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl
SDQPTY
Santo Domingo Las Americas
Sat 9/19
7:45 am-7:49 pm
1 stop13h 04m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:30 am
Nonstop0h 00m
$340
Santo DomingoPanama City
SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl
SDQPTY
Santo Domingo Las Americas
Tue 1/12
12:45 pm-5:15 pm
1 stop5h 30m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:30 am
Nonstop0h 00m
$360
Quickest round-trip
Santo DomingoPanama City
SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl
SDQPTY
Santo Domingo Las Americas
Sun 9/20
6:41 pm-8:14 pm
Nonstop2h 33m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:30 am
Nonstop0h 00m
$619
Santo DomingoPanama City
SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl
SDQPTY
Santo Domingo Las Americas
Mon 2/1
2:19 pm-3:58 pm
Nonstop2h 39m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:30 am
Nonstop0h 00m
$619
Santo DomingoPanama City
SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl
SDQPTY
Santo Domingo Las Americas
Fri 11/20
2:24 pm-3:58 pm
Nonstop2h 34m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:30 am
Nonstop0h 00m
$619
Santo DomingoPanama City
SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl
SDQPTY
Santo Domingo Las Americas
Thu 10/1
2:16 pm-3:49 pm
Nonstop2h 33m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:30 am
Nonstop0h 00m
$619
Santo DomingoPanama City
SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl
SDQPTY
Santo Domingo Las Americas
Tue 12/29
2:14 pm-3:58 pm
Nonstop2h 44m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:30 am
Nonstop0h 00m
$619
Santo DomingoPanama City
SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl
SDQPTY
Santo Domingo Las Americas
Sun 11/22
2:24 pm-3:58 pm
Nonstop2h 34m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:30 am
Nonstop0h 00m
$619
Santo DomingoPanama City
SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl
SDQPTY
Santo Domingo Las Americas
Tue 11/24
2:24 pm-3:58 pm
Nonstop2h 34m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:30 am
Nonstop0h 00m
$619
Santo DomingoPanama City
SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl
SDQPTY
Santo Domingo Las Americas
Fri 9/18
12:12 pm-1:45 pm
Nonstop2h 33m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:30 am
Nonstop0h 00m
$619
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from Santo Domingo to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santo Domingo to Panama City in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Santo Domingo-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santo Domingo-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santo Domingo-Panama City flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santo Domingo-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santo Domingo to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Santo Domingo with our price prediction graph.
SDQ-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Santo Domingo to Panama City
Prices
Airlines
Delays
How far ahead should I book a flight from Santo Domingo to Panama City?
The best time to book flights from Santo Domingo to Panama City is 89 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Santo Domingo to Panama City?
Currently, January is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of $524). Flying from Santo Domingo to Panama City in August is currently the most expensive (average of $620). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SDQ to PTY?
Find hourly flight availability from Santo Domingo to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 10, 2026.
One of the essential ways to save on airfare from Santo Domingo to Panama City is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the afternoon could potentially save you up to 8% on airfare.
What is the cheapest day to fly from Santo Domingo to Panama City?
Use this chart to determine the cheapest time to fly round-trip from Santo Domingo to Panama City. Price data was last updated on September 5, 2026.
Travelers seeking maximum savings on their Santo Domingo to Panama City flight should consider departing on Monday evenings when fares are most often at their lowest. Saturday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.
How often are flights from Santo Domingo to Panama City delayed?
About 5% of weekly flights between Santo Domingo and Panama City have experienced delays in the past year, with the average delay time being 106 minutes.
What is the most punctual flight time for Santo Domingo to Panama City flights?
Historically, flights departing at night are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Saturday tends to have the lowest number of delays on this route, whereas Friday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Santo Domingo to Panama City flights?
Over the last year, Copa Airlines have had the lowest number of delays on this route, with just 5% of flights being delayed.
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated September 10, 2026.
Read through reviews of airlines operating flights from Santo Domingo to Panama City, such as Copa Airlines and Avianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.8
Comfort
7.4
Entertainment
6.9
Food
6.9
Crew
8.1
Overall
7.6
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2026
BOS - PTY
Boarding
7.8
Comfort
7.4
Entertainment
6.9
Food
6.9
Crew
8.1
Overall
7.6
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2026
BOS - PTY
Boarding
7.8
Comfort
7.4
Entertainment
6.9
Food
6.9
Crew
8.1
Overall
7.6
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2026
BOS - PTY
Related info for your journey
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Santo Domingo and Panama City flights
Browse other Santo Domingo and Panama City flight options. Last updated on September 10, 2026.
Other flights from Santo Domingo
Browse through other flights departing from Santo Domingo. Flights are based on user searches made on Cheapflights and were last updated on September 10, 2026.
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Top 2 airlines flying from Santo Domingo to Panama City
Discover the top 2 airlines that operate flights from Santo Domingo to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$259 | Average$545 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$507 | Average$618 | FlexibilityNo cancel fee | On-time70% |