How popular is this Panama City to Santo Domingo flight route?

The Panama City Tocumen Intl to Santo Domingo Las Americas flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

What are the cheapest airlines flying from Panama City to Santo Domingo round-trip?

Cheapflights users have booked flights from Panama City to Santo Domingo round-trip from $294. Other airlines that can offer you cheap pricing are Copa Airlines, from $429, and United Airlines, from $1,465. These flights start at 28% lower than the current average price 3 months from now.

What are the cheapest airlines to fly from Panama City to Santo Domingo one-way?

To fly one-way, consider booking your trip with Avianca, which is currently one of the cheapest options available, starting at $164. Copa Airlines flights start at $474 while deals on United Airlines start at $1,010 one-way.

What is the cheapest day to fly from Panama City to Santo Domingo?

Travelers seeking maximum savings on their Panama City to Santo Domingo flight should consider departing on Thursday afternoons when fares are most often at their lowest. Monday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

What are the cheapest flights from Panama City to Santo Domingo?

Looking for the cheapest flight from Panama City to Santo Domingo? While on average our users pay $428, our data indicates the cheapest price to be $202. The most popular route (Panama City Tocumen Intl - Santo Domingo Las Americas), is priced around $378.

What are the most reliable airlines from Panama City to Santo Domingo?

No one likes to see their flight delayed. When booking a flight from Panama City to Santo Domingo consider choosing Copa Airlines (92%), KLM (90%) or Air France (90%) as they are the most reliable in getting you off to your destination on time.

What is the cheapest day to fly round-trip from Panama City to Santo Domingo?

Leaving on a Wednesday is a viable option for saving on travel. Heavily demanded days of the week can typically drive up the prices you see. Booking your travel for a less competitive day can save up to 10% on the overall cost on flights from Panama City to Santo Domingo.

How far in advance should I book a flight from Panama City to Santo Domingo?

Find a great deal and save up to 51% by booking at least 56 days prior to your desired departure date, rather than waiting until the week of travel. According to our data, there are a number of flights available from Panama City to Santo Domingo within the next two weeks, with the cheapest ticket starting at $500.

What is the cheapest month to fly from Panama City to Santo Domingo?

The best pricing can be found in the month of July. Prices to Santo Domingo from Panama City average $411. You can even find prices in July for less than $411, as users have found deals to Santo Domingo from as low as $293. The month of June appears to be one of the more expensive times to travel to Santo Domingo from Panama City. Flying in the targeted month can save you up to 4%.

What airports do I use to fly from Panama City to Santo Domingo?

If you book a flight from Panama City to Santo Domingo, you will be flying from Tocumen Intl to Las Americas. Flights to Santo Domingo Las Americas (SDQ) from Panama City Tocumen Intl (PTY) take 2h 31m for a nonstop flight. There are 7 flights from Tocumen Intl to Santo Domingo per day from 2 airlines.

Can I find deals for flights from Panama City to Santo Domingo that include hotel bookings?

Yes. In addition to deals on Panama City to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Panama City to Santo Domingo?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santo Domingo.

Can I find deals for business class flights from Panama City to Santo Domingo?

Yes. Cheapflights offers flight deals from Panama City to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$164+ Flights from Panama City to Santo Domingo

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Santo Domingo Las Americas are usually found in July or August, booked 62 days in advance, depart on a Thursday or Tuesday and return on a Thursday

Cheap flight deals from Panama City to Santo Domingo

Round-trip from	$294 (Priceline)
One-way from	$164 (FlightHub)
Popular in	June
Cheapest in	July
Average price	$428
Good round-trip deal	$428 or less

From Panama City Tocumen Intl to Santo Domingo Las Americas

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One-way flight from Panama City Tocumen Intl to Santo Domingo Las Americas

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High demand for flights, 1% potential price rise

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Cheapest flight prices on average. 0% potential price decrease ($2 potential savings vs. average RT price).

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Average for round-trip flights in June 2025

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Price to beat on a round-trip flight from Panama City Tocumen Intl to Santo Domingo Las Americas.

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Find flight deals from Panama City to Santo Domingo

Cheapest flights from Panama City to Santo Domingo
Explore the most affordable flight options available from Panama City to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 18, 2025.

Mon 7/73:25 amPTY - SDQ

1 stop12h 50mAvianca

Fri 8/86:10 pmSDQ - PTY

1 stop7h 35mAvianca

Deal found 6/17

$294

Wed 7/303:20 amPTY - SDQ

1 stop6h 30mMultiple Airlines

Thu 8/76:10 amSDQ - PTY

2 stops11h 05mMultiple Airlines

Deal found 6/15

$417

Thu 7/39:37 amPTY - SDQ

Nonstop2h 33mCopa Airlines

Thu 7/102:07 pmSDQ - PTY

Nonstop2h 35mCopa Airlines

Deal found 6/17

$429

Best flights from Panama City to Santo Domingo
Discover carefully curated flight deals from Panama City to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 18, 2025.

Mon 7/73:25 amPTY - SDQ

1 stop12h 50mAvianca

Fri 8/86:10 pmSDQ - PTY

1 stop7h 35mAvianca

Deal found 6/17

$294

Wed 7/303:20 amPTY - SDQ

1 stop6h 30mMultiple Airlines

Thu 8/76:10 amSDQ - PTY

2 stops11h 05mMultiple Airlines

Deal found 6/15

$417

Thu 7/39:37 amPTY - SDQ

Nonstop2h 33mCopa Airlines

Thu 7/102:07 pmSDQ - PTY

Nonstop2h 35mCopa Airlines

Deal found 6/17

$429

Thu 8/77:55 amPTY - SDQ

2 stops16h 55mUnited Airlines

Wed 8/131:10 pmSDQ - PTY

2 stops26h 04mUnited Airlines

Deal found 6/17

$1,465

Sat 11/88:05 amPTY - SDQ

2 stops16h 11mDelta

Mon 11/102:55 pmSDQ - PTY

2 stops23h 57mDelta

Deal found 6/16

$5,776

Last-minute flights from Panama City to Santo Domingo
Discover last-minute flight deals from Panama City to Santo Domingo. Data last updated June 18, 2025 and is based on user searches.

Sat 6/217:55 amPTY - SDQ

2 stops16h 55mUnited Airlines

Sun 6/291:10 pmSDQ - PTY

2 stops26h 04mUnited Airlines

Deal found 6/16

$1,588

Tue 6/247:55 amPTY - SDQ

2 stops16h 55mUnited Airlines

Wed 7/21:10 pmSDQ - PTY

2 stops26h 04mUnited Airlines

Deal found 6/17

$1,762

Thu 6/262:23 pmPTY - SDQ

2 stops26h 35mDelta

Thu 7/32:46 pmSDQ - PTY

1 stop29h 16mDelta

Deal found 6/17

$5,830

Thu 6/262:23 pmPTY - SDQ

2 stops26h 35mDelta

Fri 7/42:46 pmSDQ - PTY

1 stop23h 22mDelta

Deal found 6/17

$5,830

Sat 6/283:20 amPTY - SDQ

1 stop12h 55mAvianca

Mon 7/711:45 amSDQ - PTY

1 stop14h 00mAvianca

Deal found 6/16

$332

Sat 6/283:20 amPTY - SDQ

1 stop12h 55mMultiple Airlines

Mon 7/76:32 pmSDQ - PTY

2 stops30h 38mMultiple Airlines

Deal found 6/16

$493

Sat 6/2811:13 pmPTY - SDQ

Nonstop2h 32mCopa Airlines

Sat 7/52:07 pmSDQ - PTY

Nonstop2h 35mCopa Airlines

Deal found 6/16

$514

Thu 7/39:37 amPTY - SDQ

Nonstop2h 33mCopa Airlines

Thu 7/102:07 pmSDQ - PTY

Nonstop2h 35mCopa Airlines

Deal found 6/17

$429

Mon 7/73:25 amPTY - SDQ

1 stop12h 50mAvianca

Fri 8/86:10 pmSDQ - PTY

1 stop7h 35mAvianca

Deal found 6/17

$294

Wed 7/303:20 amPTY - SDQ

1 stop6h 30mMultiple Airlines

Thu 8/76:10 amSDQ - PTY

2 stops11h 05mMultiple Airlines

Deal found 6/15

$417

One-way flights from Panama City to Santo Domingo
Search for one-way flight options from Panama City to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated June 18, 2025.

Sun 8/315:25 pmPTY - SDQ

1 stop16h 25mAvianca

Deal found 6/17

$164

Sat 8/303:20 amPTY - SDQ

3 stops9h 40mMultiple Airlines

Deal found 6/17

$300

Mon 6/2311:13 pmPTY - SDQ

Nonstop2h 32mCopa Airlines

Deal found 6/16

$474

Wed 10/296:21 pmPTY - SDQ

3 stops27h 25mUnited Airlines

Deal found 6/16

$1,010

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Mon 7/7

3:25 am-5:15 pm

1 stop12h 50m

Santo Domingo Las Americas

Fri 8/8

6:10 pm-12:45 am

1 stop7h 35m

$294

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Wed 7/30

3:20 am-10:50 am

1 stop6h 30m

Santo Domingo Las Americas

Thu 8/7

6:10 am-4:15 pm

2 stops11h 05m

$417

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Thu 7/3

9:37 am-1:10 pm

Nonstop2h 33m

Santo Domingo Las Americas

Thu 7/10

2:07 pm-3:42 pm

Nonstop2h 35m

$429

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Thu 8/7

7:55 am-1:50 am

2 stops16h 55m

Santo Domingo Las Americas

Wed 8/13

1:10 pm-2:14 pm

2 stops26h 04m

$1,465

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Sat 11/8

8:05 am-1:16 am

2 stops16h 11m

Santo Domingo Las Americas

Mon 11/10

2:55 pm-1:52 pm

2 stops23h 57m

$5,776

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Sun 8/31

5:25 pm-10:50 am

1 stop16h 25m

$164

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Sat 8/30

3:20 am-2:00 pm

3 stops9h 40m

$300

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Mon 6/23

11:13 pm-2:45 am

Nonstop2h 32m

$474

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Wed 10/29

6:21 pm-10:46 pm

3 stops27h 25m

$1,010

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/17

Best time to book a flight from Panama City to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Panama City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santo Domingo

How far ahead should I book a flight from Panama City to Santo Domingo?

The price you pay for your flight from Panama City to Santo Domingo may vary depending on when you book. For the best chance of a lower fare, look to book 62 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from Panama City to Santo Domingo (average of $362). Flying from Panama City to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SDQ?

One of the essential ways to save on airfare from Panama City to Santo Domingo is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the afternoon could potentially save you up to 1% on airfare.

Weekly flight availability from Panama City to Santo Domingo

The most flights from PTY to SDQ are scheduled on a Sunday (10 on average). You will have fewer flight options on Friday, which is when the least amount of flights are scheduled (3 on average).

Rainfall in Santo Domingo by month

In terms of precipitation, rainfall in Santo Domingo ranges from 1.6 - 6.7 inches per month. May is typically the wettest month, when rainfall can reach 6.7 in. February is typically the driest time to visit Santo Domingo when rainfall is around 1.6 in.

Temperature in Santo Domingo by month

If weather is an important factor for your trip to Santo Domingo, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 75.2 F).

Reviews of airlines servicing Santo Domingo

Get a feel of what it's like to fly with Delta, Copa Airlines and United Airlines from Panama City to Santo Domingo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,964 reviews

Reviews

1 / 20

6.0

Good

Anonymous,Sep 2023

LGA - SYR

No A/C bad landing by pilot kinda scary. Not because of weather

Delta

8.0

Very good

7,964 reviews

Delta

8.0

Very good

7,964 reviews

Reviews

1 / 20

6.0

Good

Anonymous,Sep 2023

LGA - SYR

No A/C bad landing by pilot kinda scary. Not because of weather

Copa Airlines

7.5

Good

1,455 reviews

Delta

8.0

Very good

7,964 reviews

Reviews

1 / 20

6.0

Good

Anonymous,Sep 2023

LGA - SYR

No A/C bad landing by pilot kinda scary. Not because of weather

United Airlines

7.4

Good

8,810 reviews

Delta

8.0

Very good

7,964 reviews

Reviews

1 / 20

6.0

Good

Anonymous,Sep 2023

LGA - SYR

No A/C bad landing by pilot kinda scary. Not because of weather

Avianca

6.7

Okay

2,350 reviews

Delta

8.0

Very good

7,964 reviews

Reviews

1 / 20

6.0

Good

Anonymous,Sep 2023

LGA - SYR

No A/C bad landing by pilot kinda scary. Not because of weather

Related info for your journey

What airports do I use to fly from Panama City to Santo Domingo?
If you book a flight from Panama City to Santo Domingo, you will be flying from Tocumen Intl to Las Americas. Flights to Santo Domingo Las Americas (SDQ) from Panama City Tocumen Intl (PTY) take 2h 31m for a nonstop flight. There are 7 flights from Tocumen Intl to Santo Domingo per day from 2 airlines.
How popular is this Panama City to Santo Domingo flight route?
The Panama City Tocumen Intl to Santo Domingo Las Americas flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
What are the cheapest airlines flying from Panama City to Santo Domingo round-trip?
Cheapflights users have booked flights from Panama City to Santo Domingo round-trip from $294. Other airlines that can offer you cheap pricing are Copa Airlines, from $429, and United Airlines, from $1,465. These flights start at 28% lower than the current average price 3 months from now.
What are the cheapest airlines to fly from Panama City to Santo Domingo one-way?
To fly one-way, consider booking your trip with Avianca, which is currently one of the cheapest options available, starting at $164. Copa Airlines flights start at $474 while deals on United Airlines start at $1,010 one-way.
What are the most reliable airlines from Panama City to Santo Domingo?
No one likes to see their flight delayed. When booking a flight from Panama City to Santo Domingo consider choosing Copa Airlines (92%), KLM (90%) or Air France (90%) as they are the most reliable in getting you off to your destination on time.
What are the cheapest flights from Panama City to Santo Domingo?
Looking for the cheapest flight from Panama City to Santo Domingo? While on average our users pay $428, our data indicates the cheapest price to be $202. The most popular route (Panama City Tocumen Intl - Santo Domingo Las Americas), is priced around $378.
Can I find deals for flights from Panama City to Santo Domingo that include hotel bookings?
Yes. In addition to deals on Panama City to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to Santo Domingo?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santo Domingo.
Can I find deals for business class flights from Panama City to Santo Domingo?
Yes. Cheapflights offers flight deals from Panama City to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City to Santo Domingo?
Currently, January is the cheapest month in which you can book a flight from Panama City to Santo Domingo (average of $362). Flying from Panama City to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Juan Dolio

Browse thousands of different options on Cheapflights for your next trip

Top 2 airlines flying from Panama City to Santo Domingo

Airline	Cheapest	Average	Flexibility	On-time
Avianca	Cheapest$288	Average$349	FlexibilityNo cancel fee	On-time71%
Copa Airlines	Cheapest$372	Average$417	FlexibilityNo cancel fee	On-time70%

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$164+ Cheap flights from Panama City (PTY) to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/31. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to Santo Domingo with Cheapflights

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3. Compare prices and book

Cheapflights Tip: The best prices from Panama City Tocumen Intl to Santo Domingo Las Americas are usually found in July or August, booked 62 days in advance, depart on a Thursday or Tuesday and return on a Thursday

Cheap flight deals from Panama City to Santo Domingo

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Find flight deals from Panama City to Santo Domingo

Cheapest flights from Panama City to Santo DomingoExplore the most affordable flight options available from Panama City to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 18, 2025.

Explore the most affordable flight options available from Panama City to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 18, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Santo Domingo that are best for you.

Best time to book a flight from Panama City to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Panama City with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santo Domingo

How far ahead should I book a flight from Panama City to Santo Domingo?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Santo Domingo. Price data was last updated on June 13, 2025.

What is the cheapest month to book a flight from Panama City to Santo Domingo?

What is the cheapest time of day to fly from PTY to SDQ?

Find hourly flight availability from Panama City to Santo Domingo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 18, 2025.

Weekly flight availability from Panama City to Santo Domingo

Rainfall in Santo Domingo by month

Plan your trip to Santo Domingo by taking into account the average rainfall totals by month.

Temperature in Santo Domingo by month

Plan your trip to Santo Domingo by taking into account the average temperature totals by month.

Reviews of airlines servicing Santo Domingo

Get a feel of what it's like to fly with Delta, Copa Airlines and United Airlines from Panama City to Santo Domingo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airports do I use to fly from Panama City to Santo Domingo?

How popular is this Panama City to Santo Domingo flight route?

What are the cheapest airlines flying from Panama City to Santo Domingo round-trip?

What are the cheapest airlines to fly from Panama City to Santo Domingo one-way?

What are the most reliable airlines from Panama City to Santo Domingo?

What are the cheapest flights from Panama City to Santo Domingo?

Can I find deals for flights from Panama City to Santo Domingo that include hotel bookings?

How can I find direct flights from Panama City to Santo Domingo?

Can I find deals for business class flights from Panama City to Santo Domingo?

What is the cheapest month to book a flight from Panama City to Santo Domingo?

Traveling to a place near Panama City?

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Alternative routes for Panama City to Santo Domingo

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Panama City to Santo Domingo

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Cheapest flights from Panama City to Santo Domingo
Explore the most affordable flight options available from Panama City to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 18, 2025.