$299+ Cheap flights from Panama City (PTY) to Santo Domingo (SDQ)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/2. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SDQ
Sep 15 — Sep 221
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to Santo Domingo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Panama City Tocumen Intl to Santo Domingo Las Americas are usually found in January or February, booked 70 days in advance, depart on a Saturday or Thursday and return on a Thursday
Cheap flight deals from Panama City to Santo Domingo
Cheapest
Best
Last-minute
One-way
Cheapest flights from Panama City to Santo DomingoExplore the most affordable flight options available from Panama City to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 16, 2026.
Explore the most affordable flight options available from Panama City to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 16, 2026.
This Copa Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:26 pm -
Nonstop2h 30m
Sun 9/272:16 pm -
Nonstop2h 33m
Deal found 8/14![Copa Airlines logo]()
$571
This Avianca deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/29:45 am -
1 stop6h 05m
Tue 11/105:45 pm -
1 stop8h 15m
Deal found 8/11![Avianca logo]()
$593
This FlightHub deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/22:55 pm -
1 stop19h 30m
Fri 11/612:45 pm -
1 stop12h 55m
Deal found 8/12![Avianca logo]()
$597
This Avianca deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/52:55 am -
1 stop7h 55m
Fri 11/1312:45 pm -
1 stop12h 55m
Deal found 8/12![Avianca logo]()
$609
This Kiwi.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:50 pm -
1 stop16h 35m
Sun 11/85:45 pm -
1 stop8h 15m
Deal found 8/12![Avianca logo]()
$617
This Mytrip deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/85:30 am -
2 stops17h 19m
Fri 9/1112:45 pm -
1 stop12h 50m
Deal found 8/12![Multiple Airlines logo]()
$618
This FlightHub deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:55 am -
1 stop7h 30m
Fri 11/612:45 pm -
1 stop12h 55m
Deal found 8/12![Avianca logo]()
$619
This Mytrip deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:30 am -
2 stops17h 19m
Mon 9/146:50 pm -
1 stop15h 25m
Deal found 8/14![Multiple Airlines logo]()
$621
This Avianca deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/282:55 am -
1 stop7h 30m
Sun 11/812:45 pm -
1 stop13h 15m
Deal found 8/12![Avianca logo]()
$622
This Mytrip deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/29:45 am -
2 stops36h 01m
Sat 11/712:20 pm -
1 stop5h 35m
Deal found 8/14![Multiple Airlines logo]()
$629
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/129:42 am -
Nonstop2h 28m
Sun 11/228:55 am -
Nonstop2h 35m
Deal found 8/11![Copa Airlines logo]()
$632
This Mytrip deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:50 pm -
2 stops27h 56m
Thu 11/195:45 pm -
1 stop16h 05m
Deal found 8/12![Multiple Airlines logo]()
$641
Best flights from Panama City to Santo DomingoDiscover carefully curated flight deals from Panama City to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 16, 2026.
Discover carefully curated flight deals from Panama City to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 16, 2026.
This Copa Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/279:42 am -
Nonstop2h 31m
Mon 8/3112:43 pm -
Nonstop2h 32m
Deal found 8/12![Copa Airlines logo]()
$571
This Copa Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/139:42 am -
Nonstop2h 31m
Sun 9/206:41 pm -
Nonstop2h 33m
Deal found 8/14![Copa Airlines logo]()
$571
This Copa Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/37:26 pm -
Nonstop2h 32m
Thu 11/1212:45 pm -
Nonstop2h 36m
Deal found 8/13![Copa Airlines logo]()
$571
This Copa Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/210:41 pm -
Nonstop2h 27m
Sat 11/78:55 am -
Nonstop2h 35m
Deal found 8/14![Copa Airlines logo]()
$571
This Copa Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:11 am -
Nonstop2h 30m
Mon 10/52:16 pm -
Nonstop2h 33m
Deal found 8/14![Copa Airlines logo]()
$571
This Copa Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/19:42 am -
Nonstop2h 28m
Thu 11/55:55 am -
Nonstop2h 33m
Deal found 8/15![Copa Airlines logo]()
$571
This Copa Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/19:42 am -
Nonstop2h 31m
Mon 9/142:16 pm -
Nonstop2h 33m
Deal found 8/14![Copa Airlines logo]()
$571
This Copa Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/79:42 am -
Nonstop2h 31m
Wed 9/166:41 pm -
Nonstop2h 33m
Deal found 8/15![Copa Airlines logo]()
$571
This Copa Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/98:11 am -
Nonstop2h 31m
Mon 11/98:55 am -
Nonstop2h 35m
Deal found 8/15![Copa Airlines logo]()
$571
Last-minute flights from Panama City to Santo DomingoDiscover last-minute flight deals from Panama City to Santo Domingo. Data last updated August 16, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to Santo Domingo. Data last updated August 16, 2026 and is based on user searches.
This Avianca deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/164:25 am -
1 stop12h 30m
Sun 8/3012:45 pm -
1 stop12h 50m
Deal found 8/12![Avianca logo]()
$593
This Copa Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/219:42 am -
Nonstop2h 31m
Sun 8/2312:43 pm -
Nonstop2h 32m
Deal found 8/12![Copa Airlines logo]()
$656
This Mytrip deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:30 am -
2 stops17h 19m
Mon 9/146:50 pm -
1 stop15h 25m
Deal found 8/14![Multiple Airlines logo]()
$621
This Mytrip deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/45:55 pm -
1 stop23h 00m
Sun 9/134:35 pm -
2 stops25h 25m
Deal found 8/12![Multiple Airlines logo]()
$648
This Trip.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/43:05 pm -
1 stop14h 42m
Sun 9/1311:01 am -
1 stop27h 59m
Deal found 8/12![Aeromexico logo]()
$655
This Mytrip deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/85:30 am -
2 stops17h 19m
Fri 9/1112:45 pm -
1 stop12h 50m
Deal found 8/12![Multiple Airlines logo]()
$618
This deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/84:25 am -
1 stop6h 25m
Sat 9/126:50 pm -
1 stop6h 45m
Deal found 8/11![Avianca logo]()
$622
This Mytrip deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/173:10 pm -
1 stop19h 40m
Tue 9/222:10 pm -
2 stops25h 05m
Deal found 8/12![Multiple Airlines logo]()
$643
This Mytrip deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/183:10 pm -
2 stops7h 47m
Fri 9/257:48 am -
2 stops17h 47m
Deal found 8/11![Multiple Airlines logo]()
$646
This Copa Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:26 pm -
Nonstop2h 30m
Sun 9/272:16 pm -
Nonstop2h 33m
Deal found 8/14![Copa Airlines logo]()
$571
One-way flights from Panama City to Santo DomingoSearch for one-way flight options from Panama City to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated August 16, 2026.
Search for one-way flight options from Panama City to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated August 16, 2026.
This Jetabroad deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Jetabroad is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/24:25 am -
1 stop6h 25m
Deal found 8/11![Avianca logo]()
$299
This Jetabroad deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Jetabroad is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/204:25 am -
1 stop12h 30m
Deal found 8/14![Avianca logo]()
$300
This Avianca deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/215:55 pm -
1 stop16h 55m
Deal found 8/13![Avianca logo]()
$302
This Mytrip deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/273:10 pm -
2 stops21h 27m
Deal found 8/14![Multiple Airlines logo]()
$365
This Mytrip deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/33:10 pm -
2 stops21h 27m
Deal found 8/11![Multiple Airlines logo]()
$373
This Kiwi.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:35 pm -
2 stops28h 14m
Deal found 8/12![Multiple Airlines logo]()
$377
This Mytrip deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/233:10 pm -
2 stops22h 54m
Deal found 8/15![Multiple Airlines logo]()
$384
This Mytrip deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/184:25 am -
2 stops18h 24m
Deal found 8/15![Multiple Airlines logo]()
$385
This Mytrip deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/204:25 am -
2 stops32h 12m
Deal found 8/14![Multiple Airlines logo]()
$386
This Mytrip deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/225:30 am -
2 stops17h 19m
Deal found 8/15![Multiple Airlines logo]()
$399
Find flight deals from Panama City to Santo Domingo
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 16, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $571 (Copa Airlines) |
One-way from | $299 (Jetabroad) |
Popular in | July |
Cheapest in | January |
Average price | $537 |
Good round-trip deal | $549 or less |
Good one-way deal | $524 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 16, 2026.
Use the filters below to find and compare flights from Panama City to Santo Domingo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CitySanto Domingo
PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas
PTYSDQ
Panama City Tocumen Intl
Thu 8/27
9:42 am-1:13 pm
Nonstop2h 31m
Santo Domingo Las Americas
Mon 8/31
12:43 pm-2:15 pm
Nonstop2h 32m
$571
Panama CitySanto Domingo
PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas
PTYSDQ
Panama City Tocumen Intl
Sun 9/13
9:42 am-1:13 pm
Nonstop2h 31m
Santo Domingo Las Americas
Sun 9/20
6:41 pm-8:14 pm
Nonstop2h 33m
$571
Panama CitySanto Domingo
PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas
PTYSDQ
Panama City Tocumen Intl
Tue 11/3
7:26 pm-10:58 pm
Nonstop2h 32m
Santo Domingo Las Americas
Thu 11/12
12:45 pm-2:21 pm
Nonstop2h 36m
$571
Panama CitySanto Domingo
PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas
PTYSDQ
Panama City Tocumen Intl
Mon 11/2
10:41 pm-2:08 am
Nonstop2h 27m
Santo Domingo Las Americas
Sat 11/7
8:55 am-10:30 am
Nonstop2h 35m
$571
Panama CitySanto Domingo
PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas
PTYSDQ
Panama City Tocumen Intl
Thu 10/1
8:11 am-11:41 am
Nonstop2h 30m
Santo Domingo Las Americas
Mon 10/5
2:16 pm-3:49 pm
Nonstop2h 33m
$571
Quickest round-trip
Panama CitySanto Domingo
PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas
PTYSDQ
Panama City Tocumen Intl
Sun 11/1
9:42 am-1:10 pm
Nonstop2h 28m
Santo Domingo Las Americas
Thu 11/5
5:55 am-7:28 am
Nonstop2h 33m
$571
Panama CitySanto Domingo
PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas
PTYSDQ
Panama City Tocumen Intl
Tue 9/1
9:42 am-1:13 pm
Nonstop2h 31m
Santo Domingo Las Americas
Mon 9/14
2:16 pm-3:49 pm
Nonstop2h 33m
$571
Panama CitySanto Domingo
PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas
PTYSDQ
Panama City Tocumen Intl
Mon 9/7
9:42 am-1:13 pm
Nonstop2h 31m
Santo Domingo Las Americas
Wed 9/16
6:41 pm-8:14 pm
Nonstop2h 33m
$571
Panama CitySanto Domingo
PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas
PTYSDQ
Panama City Tocumen Intl
Wed 9/9
8:11 am-11:42 am
Nonstop2h 31m
Santo Domingo Las Americas
Mon 11/9
8:55 am-10:30 am
Nonstop2h 35m
$571
Cheapest one-way
Panama CitySanto Domingo
PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas
PTYSDQ
Panama City Tocumen Intl
Sun 8/23
10:42 pm-12:55 am
1 stop25h 13m
$451
Showing 1-10 of 18 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on Panama City-Santo Domingo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Santo Domingo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Santo Domingo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City-Santo Domingo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to Santo Domingo
Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Panama City with our price prediction graph.
PTY-SDQ
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to Santo Domingo
Prices
Airlines
Delays
How far ahead should I book a flight from Panama City to Santo Domingo?
The price you pay for your flight from Panama City to Santo Domingo may vary depending on when you book. For the best chance of a lower fare, look to book 55 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Panama City to Santo Domingo?
Currently, January is the cheapest month in which you can book a flight from Panama City to Santo Domingo (average of $452). Flying from Panama City to Santo Domingo in July is currently the most expensive (average of $549). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PTY to SDQ?
Find hourly flight availability from Panama City to Santo Domingo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 16, 2026.
One of the essential ways to save on airfare from Panama City to Santo Domingo is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight at noon could potentially save you up to 21% on airfare.
How often are flights from Panama City to Santo Domingo delayed?
About 4% of weekly flights between Panama City and Santo Domingo have experienced delays in the past year, with the average delay time being 101 minutes.
What is the most punctual flight time for Panama City to Santo Domingo flights?
Historically, flights departing at night are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Thursday tends to have the lowest number of delays on this route, whereas Friday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Panama City to Santo Domingo flights?
Over the last year, Copa Airlines have had the lowest number of delays on this route, with just 4% of flights being delayed.
Reviews of airlines servicing Santo Domingo
Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated August 16, 2026.
Read through reviews of airlines operating flights from Panama City to Santo Domingo, such as Copa Airlines and Avianca. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.6
Comfort
7.4
Crew
8.1
Entertainment
6.8
Boarding
7.8
Food
6.9
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Overall
7.6
Comfort
7.4
Crew
8.1
Entertainment
6.8
Boarding
7.8
Food
6.9
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Overall
7.6
Comfort
7.4
Crew
8.1
Entertainment
6.8
Boarding
7.8
Food
6.9
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Related info for your journey
Find useful and relevant information for your journey from Panama City to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Santo Domingo?
Book flights to Santo Domingo if you plan to visit one of these locationsJuan Dolio
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Top 2 airlines flying from Panama City to Santo Domingo
Discover the top 2 airlines that operate flights from Panama City to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 16, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$273 | Average$452 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$446 | Average$537 | FlexibilityNo cancel fee | On-time70% |