What are the cheapest airlines flying from Panama City to Santiago de los Caballeros round-trip?

Our cheapest airline available from Panama City to Santiago de los Caballeros is United Airlines. Our recent data shows that you can find tickets from as low as $1,010 on this airline. Additional options worth looking into are American Airlines and Delta, starting at $1,199 and $1,250 round-trip.

What is the cheapest day to fly from Panama City to Santiago de los Caballeros?

Travelers seeking maximum savings on their Panama City to Santiago de los Caballeros flight should consider departing on Thursday mornings when fares are most often at their lowest. Tuesday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

What is the cheapest day to fly round-trip from Panama City to Santiago de los Caballeros?

Users have found that leaving on a Wednesday can be a cost-effective option. It’s possible to save up to 6% on your flight compared to booking on days when demand is much higher.

What is the cheapest month to fly from Panama City to Santiago de los Caballeros?

Due to multiple factors, expect to potentially pay more when booking in April. For low rates, May can be a great choice for travel to Santiago de los Caballeros. Flights to Santiago de los Caballeros from Panama City in May are about $563 on average during May, but can be found for as low as $313.

What is the cheapest time of day to fly from PTY to STI?

When flying from Panama City to Santiago de los Caballeros, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Most accurate provider : When it comes to deals on Panama City-Santiago de los Caballeros flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Santiago de los Caballeros flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Santiago de los Caballeros flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Panama City-Santiago de los Caballeros flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Santiago de los Caballeros flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

How can I find direct flights from Panama City to Santiago de los Caballeros?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santiago de los Caballeros.

Can I find deals for business class flights from Panama City to Santiago de los Caballeros?

Yes. Cheapflights offers flight deals from Panama City to Santiago de los Caballeros by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$1,010+ Save on Flights from Panama City to Santiago de los Caballeros

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from Panama City to Santiago de los Caballeros with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

The best prices from Panama City Tocumen Intl to Santiago de los Caballeros are usually found in May or June, booked 62 days in advance, depart on a Tuesday or Wednesday and return on a Monday

Cheap flight deals from Panama City to Santiago de los Caballeros

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$1,010 (United Airlines)
Popular in	April
Cheapest in	May
Average price	$1,043
Good one-way deal	$464 or less

Provider with most accurate pricing for Panama City Tocumen Intl-Santiago de los Caballeros flight deals.

Search Deals

Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Santiago de los Caballeros flights.

Search Deals

From Panama City Tocumen Intl to Santiago de los Caballeros

Search Deals

Highest demand for flights based on searches. 29% potential increase in price ($239 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 8% potential price decrease ($45 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in March 2025

Search Deals

Price to beat on a one-way flight from Panama City Tocumen Intl to Santiago de los Caballeros.

Search Deals

Find flight deals from Panama City to Santiago de los Caballeros

Cheapest flights from Panama City to Santiago de los Caballeros
Explore the most affordable flight options available from Panama City to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 14, 2025.

Tue 4/297:55 amPTY - STI

2 stops16h 51mUnited Airlines

Tue 7/12:07 pmSTI - PTY

2 stops25h 07mUnited Airlines

Deal found 3/13

$1,010

Tue 4/291:15 pmPTY - STI

1 stop48h 11mAmerican Airlines

Tue 7/11:35 pmSTI - PTY

1 stop24h 25mAmerican Airlines

Deal found 3/13

$1,199

Fri 4/42:23 pmPTY - STI

2 stops20h 34mDelta

Sun 4/68:26 pmSTI - PTY

2 stops17h 32mDelta

Deal found 3/13

$1,250

Fri 4/45:25 pmPTY - STI

2 stops24h 25mMultiple Airlines

Sun 4/63:40 pmSTI - PTY

3 stops33h 30mMultiple Airlines

Deal found 3/13

$1,575

Best flights from Panama City to Santiago de los Caballeros
Discover carefully curated flight deals from Panama City to Santiago de los Caballeros that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 14, 2025.

Tue 4/297:55 amPTY - STI

2 stops16h 51mUnited Airlines

Tue 7/12:07 pmSTI - PTY

2 stops25h 07mUnited Airlines

Deal found 3/13

$1,010

Tue 4/291:15 pmPTY - STI

1 stop48h 11mAmerican Airlines

Tue 7/11:35 pmSTI - PTY

1 stop24h 25mAmerican Airlines

Deal found 3/13

$1,199

Fri 4/42:23 pmPTY - STI

2 stops20h 34mDelta

Sun 4/68:26 pmSTI - PTY

2 stops17h 32mDelta

Deal found 3/13

$1,250

Fri 4/45:25 pmPTY - STI

2 stops24h 25mMultiple Airlines

Sun 4/63:40 pmSTI - PTY

3 stops33h 30mMultiple Airlines

Deal found 3/13

$1,575

Last-minute flights from Panama City to Santiago de los Caballeros
Discover last-minute flight deals from Panama City to Santiago de los Caballeros. Data last updated March 14, 2025 and is based on user searches.

Fri 4/42:23 pmPTY - STI

2 stops20h 34mDelta

Sun 4/68:26 pmSTI - PTY

2 stops17h 32mDelta

Deal found 3/13

$1,250

Fri 4/45:25 pmPTY - STI

2 stops24h 25mMultiple Airlines

Sun 4/63:40 pmSTI - PTY

3 stops33h 30mMultiple Airlines

Deal found 3/13

$1,575

Tue 4/297:55 amPTY - STI

2 stops16h 51mUnited Airlines

Tue 7/12:07 pmSTI - PTY

2 stops25h 07mUnited Airlines

Deal found 3/13

$1,010

Tue 4/291:15 pmPTY - STI

1 stop48h 11mAmerican Airlines

Tue 7/11:35 pmSTI - PTY

1 stop24h 25mAmerican Airlines

Deal found 3/13

$1,199

Find flights from Panama City to Santiago de los Caballeros within your budget

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Tue 4/29

7:55 am-1:46 am

2 stops16h 51m

Santiago de los Caballeros

Tue 7/1

2:07 pm-2:14 pm

2 stops25h 07m

$1,010

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Tue 4/29

1:15 pm-2:26 pm

1 stop48h 11m

Santiago de los Caballeros

Tue 7/1

1:35 pm-1:00 pm

1 stop24h 25m

$1,199

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Fri 4/4

2:23 pm-11:57 am

2 stops20h 34m

Santiago de los Caballeros

Sun 4/6

8:26 pm-12:58 pm

2 stops17h 32m

$1,250

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Fri 4/4

5:25 pm-6:50 pm

2 stops24h 25m

Santiago de los Caballeros

Sun 4/6

3:40 pm-12:10 am

3 stops33h 30m

$1,575

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/13

Compare providers for flights from Panama City to Santiago de los Caballeros

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Santiago de los Caballeros in March.

Provider	Price Accuracy	Trust Score*
eDreams	Price Accuracy3 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Panama City-Santiago de los Caballeros flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Santiago de los Caballeros flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Santiago de los Caballeros flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Panama City-Santiago de los Caballeros flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Santiago de los Caballeros flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Santiago de los Caballeros

Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from Panama City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Panama City to Santiago de los Caballeros

Get recent, data-driven insights about flights from Panama City to Santiago de los Caballeros including ideal travel times, pricing trends, and more.

How far ahead should I book a flight from Panama City to Santiago de los Caballeros?

The price you pay for your flight from Panama City to Santiago de los Caballeros may vary depending on when you book. For the best chance of a lower fare, look to book 62 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Santiago de los Caballeros?

Currently, May is the cheapest month in which you can book a flight from Panama City to Santiago de los Caballeros (average of $347). Flying from Panama City to Santiago de los Caballeros in July is currently the most expensive (average of $631). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in Santiago de los Caballeros by month

In terms of precipitation, rainfall in Santiago de los Caballeros ranges from 3.0 - 11.6 inches per month. December is typically the wettest month, when rainfall can reach 11.6 in. July is typically the driest time to visit Santiago de los Caballeros when rainfall is around 3.0 in.

Temperature in Santiago de los Caballeros by month

If weather is an important factor for your trip to Santiago de los Caballeros, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 73.4 F).

Reviews of airlines servicing Santiago de los Caballeros

Delta

8.0

Very good

7,944 reviews

Reviews

1 / 20

10.0

Excellent

Kade,Sep 2023

LHR - SLC

It was weird that we had to check after security and go to a corral which had no bathroom or other services about an hour before boarding. Had to check out of the corral to leave and check back in.

Delta

8.0

Very good

7,944 reviews

Delta

8.0

Very good

7,944 reviews

Reviews

1 / 20

10.0

Excellent

Kade,Sep 2023

LHR - SLC

It was weird that we had to check after security and go to a corral which had no bathroom or other services about an hour before boarding. Had to check out of the corral to leave and check back in.

United Airlines

7.4

Good

8,623 reviews

Delta

8.0

Very good

7,944 reviews

Reviews

1 / 20

10.0

Excellent

Kade,Sep 2023

LHR - SLC

It was weird that we had to check after security and go to a corral which had no bathroom or other services about an hour before boarding. Had to check out of the corral to leave and check back in.

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,944 reviews

Reviews

1 / 20

10.0

Excellent

Kade,Sep 2023

LHR - SLC

It was weird that we had to check after security and go to a corral which had no bathroom or other services about an hour before boarding. Had to check out of the corral to leave and check back in.

Related info for your journey

What are the cheapest airlines flying from Panama City to Santiago de los Caballeros round-trip?
Our cheapest airline available from Panama City to Santiago de los Caballeros is United Airlines. Our recent data shows that you can find tickets from as low as $1,010 on this airline. Additional options worth looking into are American Airlines and Delta, starting at $1,199 and $1,250 round-trip.
What are the cheapest flights from Panama City to Santiago de los Caballeros?
While on average a flight from Panama City to Santiago de los Caballeros is generally $464, our data shows the cheapest flight currently is $464. When looking at the most popular route, (Panama City Tocumen Intl - Santiago de los Caballeros), you can expect to pay $1,010 for that flight.
Can I find deals for flights from Panama City to Santiago de los Caballeros that include hotel bookings?
Yes. In addition to deals on Panama City to Santiago de los Caballeros flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to Santiago de los Caballeros?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santiago de los Caballeros.
Can I find deals for business class flights from Panama City to Santiago de los Caballeros?
Yes. Cheapflights offers flight deals from Panama City to Santiago de los Caballeros by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City to Santiago de los Caballeros?
Currently, May is the cheapest month in which you can book a flight from Panama City to Santiago de los Caballeros (average of $347). Flying from Panama City to Santiago de los Caballeros in July is currently the most expensive (average of $631). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top airline flying from Panama City to Santiago de los Caballeros

Airline	Cheapest	Average	Flexibility	On-time
Copa Airlines	Cheapest$313	Average$340	FlexibilityNo cancel fee	On-time70%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

$1,010+ Cheap flights from Panama City (PTY) to Santiago de los Caballeros (STI)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/29. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to Santiago de los Caballeros with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

The best prices from Panama City Tocumen Intl to Santiago de los Caballeros are usually found in May or June, booked 62 days in advance, depart on a Tuesday or Wednesday and return on a Monday

Cheap flight deals from Panama City to Santiago de los Caballeros

Most accurate provider

Most trusted provider

Round-trip from

Popular in

Cheapest in

Average price

Good one-way deal

Find flight deals from Panama City to Santiago de los Caballeros

Cheapest flights from Panama City to Santiago de los CaballerosExplore the most affordable flight options available from Panama City to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 14, 2025.

Explore the most affordable flight options available from Panama City to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 14, 2025.

Find flights from Panama City to Santiago de los Caballeros within your budget

Compare providers for flights from Panama City to Santiago de los Caballeros

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Santiago de los Caballeros in March.

Best time to book a flight from Panama City to Santiago de los Caballeros

Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from Panama City with our price prediction graph.

Travel insights for flights from Panama City to Santiago de los Caballeros

Get recent, data-driven insights about flights from Panama City to Santiago de los Caballeros including ideal travel times, pricing trends, and more.

How far ahead should I book a flight from Panama City to Santiago de los Caballeros?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Santiago de los Caballeros. Price data was last updated on March 7, 2025.

What is the cheapest month to book a flight from Panama City to Santiago de los Caballeros?

Rainfall in Santiago de los Caballeros by month

Plan your trip to Santiago de los Caballeros by taking into account the average rainfall totals by month.

Temperature in Santiago de los Caballeros by month

Plan your trip to Santiago de los Caballeros by taking into account the average temperature totals by month.

Reviews of airlines servicing Santiago de los Caballeros

Related info for your journey

Find useful and relevant information for your journey from Panama City to Santiago de los Caballeros. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Panama City to Santiago de los Caballeros round-trip?

What are the cheapest flights from Panama City to Santiago de los Caballeros?

Can I find deals for flights from Panama City to Santiago de los Caballeros that include hotel bookings?

How can I find direct flights from Panama City to Santiago de los Caballeros?

Can I find deals for business class flights from Panama City to Santiago de los Caballeros?

What is the cheapest month to book a flight from Panama City to Santiago de los Caballeros?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to Santiago de los Caballeros

See prices for flight routes from nearby airports that may be better suited for you.

Top airline flying from Panama City to Santiago de los Caballeros

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Panama City to Santiago de los Caballeros
Explore the most affordable flight options available from Panama City to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 14, 2025.