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Santiago de los Caballeros

$450+ Cheap flights from Panama City (PTY) to Santiago de los Caballeros (STI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/18. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STI
Aug 3 — Aug 101
Mon 8/3
Mon 8/10
1 adult, Economy
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Cheap flight deals from Panama City to Santiago de los Caballeros

Cheapest flights from Panama City to Santiago de los Caballeros
Explore the most affordable flight options available from Panama City to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 4, 2026.

This Copa Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/3011:26 am
PTY
-
STI
Nonstop2h 33m
Copa Airlines
Thu 8/64:12 pm
STI
-
PTY
Nonstop2h 31m
Copa Airlines
Deal found 7/2$549
This Copa Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/2511:26 am
PTY
-
STI
Nonstop2h 33m
Copa Airlines
Sat 8/84:12 pm
STI
-
PTY
Nonstop2h 31m
Copa Airlines
Deal found 7/2$731
This Copa Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/2311:26 am
PTY
-
STI
Nonstop2h 33m
Copa Airlines
Thu 7/304:01 pm
STI
-
PTY
Nonstop2h 42m
Copa Airlines
Deal found 7/2$805
This Copa Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1311:26 am
PTY
-
STI
Nonstop2h 33m
Copa Airlines
Thu 8/204:12 pm
STI
-
PTY
Nonstop2h 31m
Copa Airlines
Deal found 7/2$828
This Copa Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/911:26 am
PTY
-
STI
Nonstop2h 33m
Copa Airlines
Thu 7/164:01 pm
STI
-
PTY
Nonstop2h 42m
Copa Airlines
Deal found 6/29$854
This FlightHub deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2910:10 am
PTY
-
STI
2 stops31h 10m
Multiple Airlines
Mon 9/149:35 pm
STI
-
PTY
2 stops28h 00m
Multiple Airlines
Deal found 6/30$973
This United Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2910:55 pm
PTY
-
STI
1 stop15h 17m
United Airlines
Mon 9/146:00 am
STI
-
PTY
1 stop14h 31m
United Airlines
Deal found 7/1$1,034
This Copa Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/2311:26 am
PTY
-
STI
Nonstop2h 33m
Copa Airlines
Thu 8/134:12 pm
STI
-
PTY
Nonstop2h 31m
Copa Airlines
Deal found 6/30$1,046
This American Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/181:16 pm
PTY
-
STI
1 stop23h 59m
American Airlines
Sun 9/203:15 pm
STI
-
PTY
1 stop46h 09m
American Airlines
Deal found 6/29$1,061

Find flight deals from Panama City to Santiago de los Caballeros

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Santiago de los Caballeros (STI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 4, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$549
(Copa Airlines)

One-way from

$450
(Priceline)

Popular in

December

Cheapest in

February

Average price

$528
Provider with most accurate pricing for Panama City Tocumen Intl-Santiago de los Caballeros flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Santiago de los Caballeros flights.
Search Deals
From Panama City Tocumen Intl to Santiago de los Caballeros
Search Deals
One-way flight from Panama City Tocumen Intl to Santiago de los Caballeros
Search Deals
Highest demand for flights based on searches. 28% potential increase in price ($224 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 15% potential price decrease ($74 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 4, 2026.
Use the filters below to find and compare flights from Panama City to Santiago de los Caballeros that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Sat 8/8

11:26 am-2:59 pm

Nonstop2h 33m

Santiago de los Caballeros

Sat 8/22

4:12 pm-5:43 pm

Nonstop2h 31m

$549

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Thu 7/30

11:26 am-2:59 pm

Nonstop2h 33m

Santiago de los Caballeros

Thu 8/6

4:12 pm-5:43 pm

Nonstop2h 31m

$549

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Sat 8/15

11:26 am-2:59 pm

Nonstop2h 33m

Santiago de los Caballeros

Sat 8/22

4:12 pm-5:43 pm

Nonstop2h 31m

$549

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Thu 8/13

11:26 am-2:59 pm

Nonstop2h 33m

Santiago de los Caballeros

Thu 8/20

4:12 pm-5:43 pm

Nonstop2h 31m

$549

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Sat 7/25

11:26 am-2:59 pm

Nonstop2h 33m

Santiago de los Caballeros

Sat 8/8

4:12 pm-5:43 pm

Nonstop2h 31m

$731

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Sat 11/28

11:26 am-2:54 pm

Nonstop2h 28m

Santiago de los Caballeros

Sat 1/9

3:54 pm-5:43 pm

Nonstop2h 49m

$828

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Mon 9/14

11:26 am-2:58 pm

Nonstop2h 32m

Santiago de los Caballeros

Mon 10/5

4:10 pm-5:43 pm

Nonstop2h 33m

$828

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Sat 8/29

10:55 pm-3:12 pm

1 stop15h 17m

Santiago de los Caballeros

Mon 9/14

6:00 am-7:31 pm

1 stop14h 31m

$1,034

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Thu 7/23

11:26 am-2:59 pm

Nonstop2h 33m

Santiago de los Caballeros

Thu 8/13

4:12 pm-5:43 pm

Nonstop2h 31m

$1,046
Cheapest one-way

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Mon 8/17

11:26 am-2:59 pm

Nonstop2h 33m

$529

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/29

Showing 1-10 of 21 resultsSorted by cheapest first
1
2
3
  • Most accurate provider: When it comes to deals on Panama City-Santiago de los Caballeros flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Santiago de los Caballeros flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Santiago de los Caballeros flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Santiago de los Caballeros flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Santiago de los Caballeros flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Santiago de los Caballeros

Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santiago de los Caballeros

What is the cheapest time of day to fly from PTY to STI?

Find hourly flight availability from Panama City to Santiago de los Caballeros. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 4, 2026.

When flying from Panama City to Santiago de los Caballeros, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Santiago de los Caballeros

Get insights into the airlines that provide service to Santiago de los Caballeros. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago de los Caballeros. Reviews last updated July 4, 2026.
See what other customers who have flown with Copa Airlines from Panama City to Santiago de los Caballeros have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,567 reviews

Entertainment

6.8

Boarding

7.8

Crew

8.1

Comfort

7.4

Overall

7.6

Food

6.9

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Copa Airlines
7.6
Good
1,567 reviews
Copa Airlines
7.6
Good
1,567 reviews

Entertainment

6.8

Boarding

7.8

Crew

8.1

Comfort

7.4

Overall

7.6

Food

6.9

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it

Related info for your journey

Find useful and relevant information for your journey from Panama City to Santiago de los Caballeros. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to Santiago de los Caballeros?

    For as low as $549, Copa Airlines can have you in Santiago de los Caballeros from Panama City in 2h 33m. There are 924 mi between Panama City and Santiago de los Caballeros. Most flights are nonstop.

  • What is the cheapest airline to fly from Panama City to Santiago de los Caballeros round-trip?

    Our cheapest airline available from Panama City to Santiago de los Caballeros is Copa Airlines. Our recent data shows that you can find tickets from as low as $436 on this airline. Copa Airlines is 22% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Panama City to Santiago de los Caballeros that include hotel bookings?

    Yes. In addition to deals on Panama City to Santiago de los Caballeros flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Santiago de los Caballeros?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santiago de los Caballeros.

  • Can I find deals for business class flights from Panama City to Santiago de los Caballeros?

    Yes. Cheapflights offers flight deals from Panama City to Santiago de los Caballeros by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Panama City to Santiago de los Caballeros

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to Punta Cana flights
Panama City to Santo Domingo flights

Top airline flying from Panama City to Santiago de los Caballeros

Discover the top airline that operate flights from Panama City to Santiago de los Caballeros. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 4, 2026.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$436Average$527FlexibilityNo cancel feeOn-time70%

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