$540+ Cheap flights from Panama City (PTY) to Santiago de los Caballeros (STI)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/19. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STI
Oct 31 — Nov 71
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to Santiago de los Caballeros with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to Santiago de los Caballeros
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Cheapest flights from Panama City to Santiago de los CaballerosExplore the most affordable flight options available from Panama City to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 1, 2026.
Explore the most affordable flight options available from Panama City to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 1, 2026.
This Copa Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1011:26 am -
Nonstop2h 32m
Sat 10/174:10 pm -
Nonstop2h 33m
Deal found 9/26![Copa Airlines logo]()
$571
This Copa Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1911:26 am -
Nonstop2h 32m
Thu 2/183:56 pm -
Nonstop2h 47m
Deal found 9/29![Copa Airlines logo]()
$629
This Copa Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/3111:26 am -
Nonstop2h 32m
Thu 1/73:54 pm -
Nonstop2h 49m
Deal found 9/29![Copa Airlines logo]()
$633
This Copa Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1011:26 am -
Nonstop2h 32m
Sat 10/314:10 pm -
Nonstop2h 33m
Deal found 9/28![Copa Airlines logo]()
$656
This Copa Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2111:26 am -
Nonstop2h 32m
Mon 1/253:54 pm -
Nonstop2h 49m
Deal found 9/29![Copa Airlines logo]()
$908
This Copa Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:26 am -
Nonstop2h 32m
Sat 10/104:10 pm -
Nonstop2h 33m
Deal found 9/26![Copa Airlines logo]()
$973
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/243:30 pm -
2 stops30h 21m
Wed 10/285:00 am -
1 stop15h 02m
Deal found 9/29![United Airlines logo]()
$1,026
This FlightHub deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2610:05 am -
2 stops26h 55m
Thu 10/2910:25 pm -
2 stops19h 50m
Deal found 9/30![Multiple Airlines logo]()
$1,190
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/262:02 pm -
1 stop47h 10m
Thu 10/293:12 pm -
1 stop22h 50m
Deal found 9/30![American Airlines logo]()
$1,212
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/222:24 pm -
2 stops21h 09m
Thu 10/297:10 pm -
2 stops18h 49m
Deal found 9/27![Delta logo]()
$1,325
Best flights from Panama City to Santiago de los CaballerosDiscover carefully curated flight deals from Panama City to Santiago de los Caballeros that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 1, 2026.
Discover carefully curated flight deals from Panama City to Santiago de los Caballeros that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 1, 2026.
This Copa Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2611:26 am -
Nonstop2h 32m
Mon 11/24:01 pm -
Nonstop2h 42m
Deal found 9/28![Copa Airlines logo]()
$571
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/243:30 pm -
2 stops30h 21m
Wed 10/285:00 am -
1 stop15h 02m
Deal found 9/29![United Airlines logo]()
$1,026
This Copa Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2111:26 am -
Nonstop2h 32m
Mon 1/253:54 pm -
Nonstop2h 49m
Deal found 9/30![Copa Airlines logo]()
$629
This Copa Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1911:26 am -
Nonstop2h 32m
Sat 1/233:54 pm -
Nonstop2h 49m
Deal found 9/29![Copa Airlines logo]()
$629
This Copa Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/3111:26 am -
Nonstop2h 32m
Thu 1/73:54 pm -
Nonstop2h 49m
Deal found 9/29![Copa Airlines logo]()
$633
Last-minute flights from Panama City to Santiago de los CaballerosDiscover last-minute flight deals from Panama City to Santiago de los Caballeros. Data last updated October 1, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to Santiago de los Caballeros. Data last updated October 1, 2026 and is based on user searches.
This Copa Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:26 am -
Nonstop2h 32m
Sat 10/104:10 pm -
Nonstop2h 33m
Deal found 9/26![Copa Airlines logo]()
$973
This Copa Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1011:26 am -
Nonstop2h 32m
Sat 10/174:10 pm -
Nonstop2h 33m
Deal found 9/26![Copa Airlines logo]()
$571
This Copa Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1011:26 am -
Nonstop2h 32m
Sat 10/314:10 pm -
Nonstop2h 33m
Deal found 9/28![Copa Airlines logo]()
$656
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/123:30 pm -
2 stops22h 42m
Wed 10/144:23 pm -
2 stops27h 14m
Deal found 9/26![United Airlines logo]()
$1,370
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/222:24 pm -
2 stops21h 09m
Thu 10/297:10 pm -
2 stops18h 49m
Deal found 9/27![Delta logo]()
$1,325
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/243:30 pm -
2 stops30h 21m
Wed 10/285:00 am -
1 stop15h 02m
Deal found 9/29![United Airlines logo]()
$1,026
This FlightHub deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2610:05 am -
2 stops26h 55m
Thu 10/2910:25 pm -
2 stops19h 50m
Deal found 9/30![Multiple Airlines logo]()
$1,190
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/262:02 pm -
1 stop47h 10m
Thu 10/293:12 pm -
1 stop22h 50m
Deal found 9/30![American Airlines logo]()
$1,212
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/262:02 pm -
1 stop23h 10m
Mon 11/22:16 pm -
1 stop48h 57m
Deal found 9/28![American Airlines logo]()
$1,364
One-way flights from Panama City to Santiago de los CaballerosSearch for one-way flight options from Panama City to Santiago de los Caballeros. Find affordable one-way fares based on user searches. Data last updated October 1, 2026.
Search for one-way flight options from Panama City to Santiago de los Caballeros. Find affordable one-way fares based on user searches. Data last updated October 1, 2026.
This Copa Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1911:26 am -
Nonstop2h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![Copa Airlines logo]()
$540
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/132:26 pm -
1 stop21h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![American Airlines logo]()
$562
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/23:24 pm -
2 stops26h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/26![Delta logo]()
$623
This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/43:29 pm -
2 stops32h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![Delta logo]()
$725
This Delta deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/62:24 pm -
2 stops21h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Delta logo]()
$742
This Kiwi.com deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/1312:03 pm -
2 stops22h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![Multiple Airlines logo]()
$808
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/248:55 am -
2 stops25h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![United Airlines logo]()
$1,276
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1812:03 pm -
2 stops25h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![United Airlines logo]()
$1,446
Find flight deals from Panama City to Santiago de los Caballeros
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Santiago de los Caballeros (STI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 1, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $571 (Copa Airlines) |
One-way from | $540 (Copa Airlines) |
Popular in | December |
Cheapest in | February |
Average price | $570 |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 1, 2026.
Use the filters below to find and compare flights from Panama City to Santiago de los Caballeros that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Panama CitySantiago de los Caballeros
PTY Panama City Tocumen Intl - STI Santiago de los Caballeros
PTYSTI
Panama City Tocumen Intl
Mon 11/2
11:26 am-2:54 pm
Nonstop2h 28m
Santiago de los Caballeros
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$540
Panama CitySantiago de los Caballeros
PTY Panama City Tocumen Intl - STI Santiago de los Caballeros
PTYSTI
Panama City Tocumen Intl
Mon 10/19
11:26 am-2:58 pm
Nonstop2h 32m
Santiago de los Caballeros
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$540
Panama CitySantiago de los Caballeros
PTY Panama City Tocumen Intl - STI Santiago de los Caballeros
PTYSTI
Panama City Tocumen Intl
Mon 10/26
11:26 am-2:58 pm
Nonstop2h 32m
Santiago de los Caballeros
Mon 11/2
4:01 pm-5:43 pm
Nonstop2h 42m
$571
Panama CitySantiago de los Caballeros
PTY Panama City Tocumen Intl - STI Santiago de los Caballeros
PTYSTI
Panama City Tocumen Intl
Mon 11/2
3:24 pm-6:33 pm
2 stops26h 09m
Santiago de los Caballeros
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$623
Panama CitySantiago de los Caballeros
PTY Panama City Tocumen Intl - STI Santiago de los Caballeros
PTYSTI
Panama City Tocumen Intl
Mon 12/21
11:26 am-2:58 pm
Nonstop2h 32m
Santiago de los Caballeros
Mon 1/25
3:54 pm-5:43 pm
Nonstop2h 49m
$629
Panama CitySantiago de los Caballeros
PTY Panama City Tocumen Intl - STI Santiago de los Caballeros
PTYSTI
Panama City Tocumen Intl
Sat 12/19
11:26 am-2:58 pm
Nonstop2h 32m
Santiago de los Caballeros
Sat 1/23
3:54 pm-5:43 pm
Nonstop2h 49m
$629
Panama CitySantiago de los Caballeros
PTY Panama City Tocumen Intl - STI Santiago de los Caballeros
PTYSTI
Panama City Tocumen Intl
Thu 12/31
11:26 am-2:58 pm
Nonstop2h 32m
Santiago de los Caballeros
Thu 1/7
3:54 pm-5:43 pm
Nonstop2h 49m
$633
Panama CitySantiago de los Caballeros
PTY Panama City Tocumen Intl - STI Santiago de los Caballeros
PTYSTI
Panama City Tocumen Intl
Fri 12/4
3:29 pm-12:54 am
2 stops32h 25m
Santiago de los Caballeros
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$725
Panama CitySantiago de los Caballeros
PTY Panama City Tocumen Intl - STI Santiago de los Caballeros
PTYSTI
Panama City Tocumen Intl
Tue 10/6
2:24 pm-12:33 pm
2 stops21h 09m
Santiago de los Caballeros
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$742
Panama CitySantiago de los Caballeros
PTY Panama City Tocumen Intl - STI Santiago de los Caballeros
PTYSTI
Panama City Tocumen Intl
Wed 1/13
12:33 pm-12:55 pm
3 stops23h 22m
Santiago de los Caballeros
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$935
Showing 1-10 of 13 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on Panama City-Santiago de los Caballeros flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Santiago de los Caballeros flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Santiago de los Caballeros flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City-Santiago de los Caballeros flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Santiago de los Caballeros flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to Santiago de los Caballeros
Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from Panama City with our price prediction graph.
PTY-STI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to Santiago de los Caballeros
What is the cheapest month to book a flight from Panama City to Santiago de los Caballeros?
Currently, February is the cheapest month in which you can book a flight from Panama City to Santiago de los Caballeros (average of $350). Flying from Panama City to Santiago de los Caballeros in December is currently the most expensive (average of $581). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PTY to STI?
Find hourly flight availability from Panama City to Santiago de los Caballeros. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 1, 2026.
When flying from Panama City to Santiago de los Caballeros, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
Reviews of airlines servicing Santiago de los Caballeros
Get insights into the airlines that provide service to Santiago de los Caballeros. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago de los Caballeros. Reviews last updated October 1, 2026.
See what other customers who have flown with Copa Airlines from Panama City to Santiago de los Caballeros have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.6
Crew
8.1
Boarding
7.8
Food
6.9
Comfort
7.4
Entertainment
6.9
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Overall
7.6
Crew
8.1
Boarding
7.8
Food
6.9
Comfort
7.4
Entertainment
6.9
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Related info for your journey
Find useful and relevant information for your journey from Panama City to Santiago de los Caballeros. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
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Popular flights
Santiago de los Caballeros flight routes
Alternative routes for Panama City to Santiago de los Caballeros
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago de los Caballeros by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Panama City to Santiago de los Caballeros by cabin class
Find flights from Panama City to Santiago de los Caballeros, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Panama City and Santiago de los Caballeros flights
Browse other Panama City and Santiago de los Caballeros flight options. Last updated on October 1, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on October 1, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago de los Caballeros
Explore flights to Santiago de los Caballeros departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 1, 2026.
Top airline flying from Panama City to Santiago de los Caballeros
Discover the top airline that operate flights from Panama City to Santiago de los Caballeros. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 1, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$436 | Average$528 | FlexibilityNo cancel fee | On-time70% |