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Santiago de los Caballeros

$492+ Cheap flights from Panama City (PTY) to Santiago de los Caballeros (STI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/11. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STI
Jul 7 — Jul 141
Mon 7/7
Mon 7/14
1 adult, Economy
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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Santiago de los Caballeros are usually found in June or July, booked 62 days in advance, depart on a Tuesday or Monday and return on a Tuesday

Cheap flight deals from Panama City to Santiago de los Caballeros

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Santiago de los Caballeros (STI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 2, 2025.

Round-trip from

$844
(Mytrip)

One-way from

$492
(Kiwi.com)

Popular in

April

Cheapest in

June

Average price

$340

Good one-way deal

$464 or less
From Panama City Tocumen Intl to Santiago de los Caballeros
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One-way flight from Panama City Tocumen Intl to Santiago de los Caballeros
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Highest demand for flights based on searches. 43% potential increase in price ($490 potential increase over avg. RT price).
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Cheapest flight prices on average. 11% potential price decrease ($69 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Price to beat on a one-way flight from Panama City Tocumen Intl to Santiago de los Caballeros.
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Find flight deals from Panama City to Santiago de los Caballeros

Cheapest flights from Panama City to Santiago de los Caballeros
Explore the most affordable flight options available from Panama City to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2025.

This Mytrip deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/313:20 amPTY - STI
3 stops29h 30mMultiple Airlines
Sun 8/3110:20 amSTI - PTY
3 stops30h 55mMultiple Airlines
Deal found 7/1$844
This United Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/3010:00 amPTY - STI
2 stops14h 46mUnited Airlines
Fri 10/32:07 pmSTI - PTY
2 stops29h 30mUnited Airlines
Deal found 6/29$1,010
This American Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/13:10 pmPTY - STI
1 stop53h 09mAmerican Airlines
Sun 8/317:00 amSTI - PTY
1 stop32h 30mAmerican Airlines
Deal found 7/1$1,123
This Delta deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/92:05 pmPTY - STI
2 stops21h 38mDelta
Tue 9/168:40 pmSTI - PTY
2 stops17h 15mDelta
Deal found 7/2$1,255

Cheapflights Fare Finder

Customize your flight search to find flights from Panama City to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2025.
Use the filters below to find and compare flights from Panama City to Santiago de los Caballeros that are best for you.

Fly from

Panama City

Fly to

Santiago de los Caballeros

Route

Depart

Return

Price

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Thu 7/31

3:20 am-9:50 am

3 stops29h 30m

Santiago de los Caballeros

Sun 8/31

10:20 am-4:15 pm

3 stops30h 55m

$844

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Tue 9/30

10:00 am-1:46 am

2 stops14h 46m

Santiago de los Caballeros

Fri 10/3

2:07 pm-6:37 pm

2 stops29h 30m

$1,010

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Fri 8/1

3:10 pm-9:19 pm

1 stop53h 09m

Santiago de los Caballeros

Sun 8/31

7:00 am-2:30 pm

1 stop32h 30m

$1,123

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Tue 9/9

2:05 pm-12:43 pm

2 stops21h 38m

Santiago de los Caballeros

Tue 9/16

8:40 pm-12:55 pm

2 stops17h 15m

$1,255

Panama CitySantiago de los Caballeros

PTY - STI

PTYSTI

Panama City Tocumen Intl

Fri 7/11

10:05 pm-9:50 am

3 stops34h 45m

$492

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/30

Best time to book a flight from Panama City to Santiago de los Caballeros

Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santiago de los Caballeros

How far ahead should I book a flight from Panama City to Santiago de los Caballeros?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Santiago de los Caballeros. Price data was last updated on June 27, 2025.

The price you pay for your flight from Panama City to Santiago de los Caballeros may vary depending on when you book. For the best chance of a lower fare, look to book 62 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Santiago de los Caballeros?

Currently, May is the cheapest month in which you can book a flight from Panama City to Santiago de los Caballeros (average of $347). Flying from Panama City to Santiago de los Caballeros in July is currently the most expensive (average of $629). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santiago de los Caballeros

Get insights into the airlines that provide service to Santiago de los Caballeros. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago de los Caballeros. Reviews last updated July 2, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Panama City to Santiago de los Caballeros have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,983 reviews

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kade,Sep 2023

LHR - SLC

It was weird that we had to check after security and go to a corral which had no bathroom or other services about an hour before boarding. Had to check out of the corral to leave and check back in.
Delta
8.0
Very good
7,983 reviews
Delta
8.0
Very good
7,983 reviews

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kade,Sep 2023

LHR - SLC

It was weird that we had to check after security and go to a corral which had no bathroom or other services about an hour before boarding. Had to check out of the corral to leave and check back in.
United Airlines
7.4
Good
8,861 reviews
Delta
8.0
Very good
7,983 reviews

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kade,Sep 2023

LHR - SLC

It was weird that we had to check after security and go to a corral which had no bathroom or other services about an hour before boarding. Had to check out of the corral to leave and check back in.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,983 reviews

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kade,Sep 2023

LHR - SLC

It was weird that we had to check after security and go to a corral which had no bathroom or other services about an hour before boarding. Had to check out of the corral to leave and check back in.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Santiago de los Caballeros. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Panama City to Santiago de los Caballeros round-trip?

    Our cheapest airline available from Panama City to Santiago de los Caballeros is United Airlines. Our recent data shows that you can find tickets from as low as $1,010 on this airline. Additional options worth looking into are American Airlines and Delta, starting at $1,123 and $1,255 round-trip.

  • What are the cheapest flights from Panama City to Santiago de los Caballeros?

    While on average a flight from Panama City to Santiago de los Caballeros is generally $464, our data shows the cheapest flight currently is $464. When looking at the most popular route, (Panama City Tocumen Intl - Santiago de los Caballeros), you can expect to pay $968 for that flight.

  • Can I find deals for flights from Panama City to Santiago de los Caballeros that include hotel bookings?

    Yes. In addition to deals on Panama City to Santiago de los Caballeros flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Santiago de los Caballeros?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santiago de los Caballeros.

  • Can I find deals for business class flights from Panama City to Santiago de los Caballeros?

    Yes. Cheapflights offers flight deals from Panama City to Santiago de los Caballeros by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Santiago de los Caballeros?

    Currently, May is the cheapest month in which you can book a flight from Panama City to Santiago de los Caballeros (average of $347). Flying from Panama City to Santiago de los Caballeros in July is currently the most expensive (average of $629). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Panama City to Santiago de los Caballeros

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to Santo Domingo flights
Panama City to Punta Cana flights

Top airline flying from Panama City to Santiago de los Caballeros

Discover the top airline that operate flights from Panama City to Santiago de los Caballeros. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$340Average$360FlexibilityNo cancel feeOn-time70%

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