$351+ Cheap flights from Panama City (PTY) to St. Louis (STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/12. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STL
May 31 — Jun 71
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to St. Louis
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Cheapest flights from Panama City to St. LouisExplore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2026.
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2026.
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/271:24 pm
PTY
- STL
1 stop9h 16m
American Airlines
Sun 8/305:00 am
STL
- PTY
1 stop7h 24m
American Airlines
Deal found 4/28![American Airlines logo]()
$654
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2710:00 am
PTY
- STL
2 stops22h 37m
United Airlines
Sun 8/308:30 pm
STL
- PTY
2 stops17h 44m
United Airlines
Deal found 4/28![United Airlines logo]()
$656
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/22:43 pm
PTY
- STL
2 stops20h 54m
American Airlines
Wed 11/113:02 pm
STL
- PTY
2 stops21h 34m
American Airlines
Deal found 4/30![American Airlines logo]()
$659
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/28:55 am
PTY
- STL
1 stop8h 40m
United Airlines
Wed 11/118:50 am
STL
- PTY
1 stop9h 48m
United Airlines
Deal found 4/28![United Airlines logo]()
$665
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/63:30 pm
PTY
- STL
2 stops19h 04m
United Airlines
Thu 9/106:00 am
STL
- PTY
2 stops13h 31m
United Airlines
Deal found 4/28![United Airlines logo]()
$677
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/281:14 pm
PTY
- STL
2 stops10h 30m
American Airlines
Thu 6/45:40 pm
STL
- PTY
2 stops18h 33m
American Airlines
Deal found 4/28![American Airlines logo]()
$683
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/210:00 am
PTY
- STL
1 stop10h 42m
United Airlines
Fri 7/108:35 am
STL
- PTY
1 stop7h 37m
United Airlines
Deal found 4/29![United Airlines logo]()
$686
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/129:45 am
PTY
- STL
1 stop14h 00m
United Airlines
Fri 7/175:33 pm
STL
- PTY
2 stops20h 41m
United Airlines
Deal found 4/29![United Airlines logo]()
$699
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/161:49 pm
PTY
- STL
1 stop9h 04m
American Airlines
Tue 5/195:24 am
STL
- PTY
1 stop7h 22m
American Airlines
Deal found 4/30![American Airlines logo]()
$740
Best flights from Panama City to St. LouisDiscover carefully curated flight deals from Panama City to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 1, 2026.
Discover carefully curated flight deals from Panama City to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 1, 2026.
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2710:00 am
PTY
- STL
2 stops22h 37m
United Airlines
Sun 8/308:30 pm
STL
- PTY
2 stops17h 44m
United Airlines
Deal found 4/28![United Airlines logo]()
$656
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/63:30 pm
PTY
- STL
2 stops19h 04m
United Airlines
Thu 9/106:00 am
STL
- PTY
2 stops12h 37m
United Airlines
Deal found 4/30![United Airlines logo]()
$677
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1310:00 am
PTY
- STL
1 stop12h 45m
United Airlines
Fri 7/178:35 pm
STL
- PTY
2 stops19h 37m
United Airlines
Deal found 4/29![United Airlines logo]()
$677
Last-minute flights from Panama City to St. LouisDiscover last-minute flight deals from Panama City to St. Louis. Data last updated May 1, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to St. Louis. Data last updated May 1, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:55 pm
PTY
- STL
2 stops13h 52m
United Airlines
Tue 5/56:00 am
STL
- PTY
1 stop10h 12m
United Airlines
Deal found 4/29![United Airlines logo]()
$840
This Mytrip deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/13:50 pm
PTY
- STL
2 stops27h 37m
Avianca
Tue 5/58:45 am
STL
- PTY
3 stops30h 10m
Avianca
Deal found 4/29![Avianca logo]()
$1,002
This United Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/83:30 pm
PTY
- STL
1 stop18h 00m
United Airlines
Tue 5/126:00 am
STL
- PTY
1 stop8h 14m
United Airlines
Deal found 4/26![United Airlines logo]()
$810
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/122:15 pm
PTY
- STL
1 stop7h 23m
Delta
Fri 5/156:00 am
STL
- PTY
1 stop6h 50m
Delta
Deal found 4/28![Delta logo]()
$741
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1210:00 am
PTY
- STL
2 stops22h 39m
United Airlines
Fri 5/156:00 am
STL
- PTY
1 stop10h 12m
United Airlines
Deal found 4/28![United Airlines logo]()
$763
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/161:49 pm
PTY
- STL
1 stop9h 04m
American Airlines
Tue 5/195:24 am
STL
- PTY
1 stop7h 22m
American Airlines
Deal found 4/30![American Airlines logo]()
$740
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/281:14 pm
PTY
- STL
2 stops10h 30m
American Airlines
Thu 6/45:40 pm
STL
- PTY
2 stops18h 33m
American Airlines
Deal found 4/28![American Airlines logo]()
$683
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:55 am
PTY
- STL
1 stop12h 47m
United Airlines
Thu 6/46:00 am
STL
- PTY
1 stop13h 31m
United Airlines
Deal found 4/28![United Airlines logo]()
$699
This Mytrip deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:25 am
PTY
- STL
3 stops31h 41m
Multiple Airlines
Thu 6/42:15 pm
STL
- PTY
3 stops34h 20m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$977
One-way flights from Panama City to St. LouisSearch for one-way flight options from Panama City to St. Louis. Find affordable one-way fares based on user searches. Data last updated May 1, 2026.
Search for one-way flight options from Panama City to St. Louis. Find affordable one-way fares based on user searches. Data last updated May 1, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/123:10 pm
PTY
- STL
3 stops27h 24m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$351
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/204:25 am
PTY
- STL
2 stops34h 24m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/221:14 pm
PTY
- STL
1 stop9h 39m
American Airlines
Deal found 4/30![American Airlines logo]()
$365
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/194:25 am
PTY
- STL
2 stops34h 24m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$373
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/239:48 pm
PTY
- STL
2 stops17h 01m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$376
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/218:25 am
PTY
- STL
2 stops24h 32m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$379
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2010:55 pm
PTY
- STL
1 stop24h 41m
United Airlines
Deal found 4/30![United Airlines logo]()
$382
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/2610:00 am
PTY
- STL
1 stop24h 07m
United Airlines
Deal found 4/28![United Airlines logo]()
$401
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/199:33 pm
PTY
- STL
2 stops21h 01m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$403
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/273:30 pm
PTY
- STL
2 stops20h 41m
United Airlines
Deal found 4/28![United Airlines logo]()
$404
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/224:25 am
PTY
- STL
3 stops33h 42m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$417
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/1910:55 pm
PTY
- STL
1 stop24h 40m
United Airlines
Deal found 4/28![United Airlines logo]()
$425
Find flight deals from Panama City to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 1, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $654 (American Airlines) |
One-way from | $351 (Kiwi.com) |
Popular in | November |
Cheapest in | March |
Average price | $684 |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2026.
Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CitySt. Louis
PTY - STL
PTYSTL
Panama City Tocumen Intl
Thu 8/27
10:00 am-8:37 am
2 stops22h 37m
Lambert-St Louis
Sun 8/30
8:30 pm-2:14 pm
2 stops17h 44m
$656
Quickest round-trip
Panama CitySt. Louis
PTY - STL
PTYSTL
Panama City Tocumen Intl
Sun 9/6
3:30 pm-10:34 am
2 stops19h 04m
Lambert-St Louis
Thu 9/10
6:00 am-6:37 pm
2 stops12h 37m
$677
Panama CitySt. Louis
PTY - STL
PTYSTL
Panama City Tocumen Intl
Mon 7/13
10:00 am-10:45 pm
1 stop12h 45m
Lambert-St Louis
Fri 7/17
8:35 pm-4:12 pm
2 stops19h 37m
$677
Cheapest one-way
Panama CitySt. Louis
PTY - STL
PTYSTL
Panama City Tocumen Intl
Fri 6/12
3:10 pm-6:34 pm
3 stops27h 24m
$351
Panama CitySt. Louis
PTY - STL
PTYSTL
Panama City Tocumen Intl
Tue 7/21
8:25 am-8:57 am
2 stops24h 32m
$379
Panama CitySt. Louis
PTY - STL
PTYSTL
Panama City Tocumen Intl
Mon 7/20
10:55 pm-11:36 pm
1 stop24h 41m
$382
Panama CitySt. Louis
PTY - STL
PTYSTL
Panama City Tocumen Intl
Sun 6/28
10:55 pm-11:45 pm
1 stop24h 50m
$401
Panama CitySt. Louis
PTY - STL
PTYSTL
Panama City Tocumen Intl
Fri 6/26
3:30 pm-10:34 am
2 stops19h 04m
$401
Panama CitySt. Louis
PTY - STL
PTYSTL
Panama City Tocumen Intl
Fri 6/19
9:33 pm-6:34 pm
2 stops21h 01m
$403
Panama CitySt. Louis
PTY - STL
PTYSTL
Panama City Tocumen Intl
Sat 6/27
3:30 pm-12:11 pm
2 stops20h 41m
$404
Showing 1-10 of 13 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on Panama City-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.
PTY-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to St. Louis
What is the cheapest month to book a flight from Panama City to St. Louis?
Currently, March is the cheapest month in which you can book a flight from Panama City to St. Louis (average of $360). Flying from Panama City to St. Louis in November is currently the most expensive (average of $706). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Panama City to St. Louis?
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated May 1, 2026.
Read through reviews of airlines operating flights from Panama City to St. Louis, such as United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.1
Boarding
7.7
Entertainment
7.1
Food
6.6
Comfort
7.3
Overall
7.4
Reviews
1 / 20
8.0
ExcellentAnonymous,Apr 2026
DFW - EWR
Crew
8.1
Boarding
7.7
Entertainment
7.1
Food
6.6
Comfort
7.3
Overall
7.4
Reviews
1 / 20
8.0
ExcellentAnonymous,Apr 2026
DFW - EWR
Related info for your journey
Find useful and relevant information for your journey from Panama City to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Festus
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Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.
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Panama City and St. Louis flights
Browse other Panama City and St. Louis flight options. Last updated on May 1, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on May 1, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 1, 2026.
Top airline flying from Panama City to St. Louis
Discover the top airline that operate flights from Panama City to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$252 | Average$684 | FlexibilityNo cancel fee | On-time69% |