HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
St. Louis

$312+ Cheap flights from Panama City (PTY) to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/28. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STL
Jul 16 — Jul 231
Wed 7/16
Wed 7/23
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama City to St. Louis with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Panama City to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 11, 2025.

Round-trip from

$515
(United Airlines)

One-way from

$312
(United Airlines)

Popular in

January

Cheapest in

June

Average price

$560
From Panama City Tocumen Intl to Lambert-St Louis
Search Deals
One-way flight from Panama City Tocumen Intl to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($37 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2025
Search Deals

Find flight deals from Panama City to St. Louis

Cheapest flights from Panama City to St. Louis
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 11, 2025.

This United Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/264:41 pmPTY - STL
2 stops18h 46mUnited Airlines
Sun 11/304:17 pmSTL - PTY
1 stop26h 21mUnited Airlines
Deal found 7/10$515
This Delta deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/272:10 pmPTY - STL
1 stop7h 50mDelta
Tue 9/306:04 amSTL - PTY
1 stop6h 51mDelta
Deal found 7/9$546
This American Airlines deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/273:30 pmPTY - STL
1 stop8h 29mAmerican Airlines
Fri 9/55:28 amSTL - PTY
1 stop9h 03mAmerican Airlines
Deal found 7/9$547
This Mytrip deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/73:20 amPTY - STL
3 stops35h 19mMultiple Airlines
Tue 9/94:05 pmSTL - PTY
2 stops18h 05mMultiple Airlines
Deal found 7/10$916

Cheapflights Fare Finder

Customize your flight search to find flights from Panama City to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 11, 2025.
Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.

Fly from

Panama City

Fly to

St. Louis

Route

Depart

Return

Price

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Wed 11/26

4:41 pm-10:04 am

1 stop18h 23m

Lambert-St Louis

Sun 11/30

4:17 pm-7:38 pm

1 stop26h 21m

$515

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 9/27

2:10 pm-10:00 pm

1 stop7h 50m

Lambert-St Louis

Tue 9/30

6:04 am-12:55 pm

1 stop6h 51m

$546

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Wed 8/27

3:30 pm-11:59 pm

1 stop8h 29m

Lambert-St Louis

Fri 9/5

5:28 am-2:31 pm

1 stop9h 03m

$547

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 8/7

3:20 am-2:39 pm

3 stops35h 19m

Lambert-St Louis

Tue 9/9

4:05 pm-10:10 am

2 stops18h 05m

$916

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 8/28

3:30 pm-12:25 pm

2 stops20h 55m

$312

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sun 8/3

3:20 am-4:31 pm

2 stops37h 11m

$316

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Fri 8/29

3:30 pm-11:59 pm

1 stop8h 29m

$317

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 8/4

2:28 pm-11:53 pm

1 stop9h 25m

$401

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Fri 7/18

6:38 pm-9:59 am

1 stop15h 21m

$1,288

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/9

Best time to book a flight from Panama City to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to St. Louis

What is the cheapest time of day to fly from PTY to STL?

Find hourly flight availability from Panama City to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 11, 2025.

When flying from Panama City to St. Louis, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 7% versus a flight in the morning.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated July 11, 2025.
Read through reviews of airlines operating flights from Panama City to St. Louis, such as Delta, Copa Airlines, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,951 reviews

Entertainment

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Overall

8.0

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.
Delta
8.0
Very good
7,951 reviews
Delta
8.0
Very good
7,951 reviews

Entertainment

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Overall

8.0

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.
Copa Airlines
7.5
Good
1,475 reviews
Delta
8.0
Very good
7,951 reviews

Entertainment

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Overall

8.0

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.
United Airlines
7.4
Good
8,846 reviews
Delta
8.0
Very good
7,951 reviews

Entertainment

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Overall

8.0

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,951 reviews

Entertainment

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Overall

8.0

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.

Related info for your journey

Find useful and relevant information for your journey from Panama City to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Panama City to St. Louis round-trip?

    Our cheapest airline available from Panama City to St. Louis is United Airlines. Our recent data shows that you can find tickets from as low as $515 on this airline. Additional options worth looking into are Delta and American Airlines, starting at $546 and $547 round-trip. You may be able to fly from Panama City to St. Louis for 6% less than the average price by searching for these airlines.

  • What are the cheapest airlines to fly from Panama City to St. Louis one-way?

    The cheapest airlines for a one-way flight from Panama City to St. Louis are United Airlines ($312), American Airlines ($317), and Delta ($401).

  • Can I find deals for flights from Panama City to St. Louis that include hotel bookings?

    Yes. In addition to deals on Panama City to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to St. Louis.

  • Can I find deals for business class flights from Panama City to St. Louis?

    Yes. Cheapflights offers flight deals from Panama City to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from Panama City to St. Louis (average of $311). Flying from Panama City to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
O'Fallon
Maryland Heights
Fairview Heights
Collinsville
Eureka
St. Peters
Glencoe
Alton
Festus
Chesterfield
Farmington

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to Kansas City flights
Panama City to Springfield flights

Top 2 airlines flying from Panama City to St. Louis

Discover the top 2 airlines that operate flights from Panama City to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$354Average$558FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$460Average$610FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.