$342+ Cheap flights from Panama City (PTY) to St. Louis (STL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/20. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STL
Nov 29 — Dec 61
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to St. Louis
Cheapest
Best
Last-minute
One-way
Cheapest flights from Panama City to St. LouisExplore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/193:29 pm -
1 stop9h 27m
Wed 1/276:00 am -
1 stop7h 04m
Deal found 10/26![Delta logo]()
$728
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/193:34 pm -
2 stops22h 10m
Wed 1/275:00 pm -
2 stops19h 26m
Deal found 10/26![American Airlines logo]()
$781
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/310:00 am -
2 stops25h 32m
Mon 11/96:15 am -
1 stop12h 23m
Deal found 10/30![United Airlines logo]()
$808
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/283:41 pm -
2 stops17h 14m
Wed 11/46:50 pm -
2 stops24h 12m
Deal found 10/28![United Airlines logo]()
$822
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:41 pm -
1 stop23h 32m
Sat 11/72:55 pm -
1 stop22h 50m
Deal found 10/30![United Airlines logo]()
$884
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/33:13 pm -
1 stop25h 37m
Mon 11/94:11 pm -
2 stops21h 02m
Deal found 10/29![American Airlines logo]()
$904
This Mytrip deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/264:10 pm -
3 stops26h 30m
Thu 12/36:13 pm -
3 stops30h 07m
Deal found 10/29![Multiple Airlines logo]()
$1,369
This Booking.com deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:10 pm -
3 stops24h 30m
Wed 1/274:05 pm -
2 stops16h 05m
Deal found 10/26![Multiple Airlines logo]()
$1,503
Best flights from Panama City to St. LouisDiscover carefully curated flight deals from Panama City to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
Discover carefully curated flight deals from Panama City to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/253:29 pm -
1 stop8h 57m
Sun 1/316:00 am -
1 stop7h 04m
Deal found 10/28![Delta logo]()
$609
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/254:55 pm -
2 stops22h 10m
Sun 1/316:06 pm -
1 stop18h 20m
Deal found 10/28![American Airlines logo]()
$645
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/274:41 pm -
1 stop17h 50m
Sun 1/316:45 pm -
2 stops21h 27m
Deal found 10/29![United Airlines logo]()
$693
Last-minute flights from Panama City to St. LouisDiscover last-minute flight deals from Panama City to St. Louis. Data last updated October 30, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to St. Louis. Data last updated October 30, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:41 pm -
1 stop23h 32m
Sat 11/72:55 pm -
1 stop22h 50m
Deal found 10/30![United Airlines logo]()
$884
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/310:00 am -
2 stops23h 55m
Mon 11/96:50 pm -
2 stops24h 12m
Deal found 10/30![United Airlines logo]()
$808
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/33:13 pm -
1 stop25h 37m
Mon 11/94:11 pm -
2 stops21h 02m
Deal found 10/29![American Airlines logo]()
$904
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/193:29 pm -
1 stop9h 27m
Wed 1/276:00 am -
1 stop7h 04m
Deal found 10/26![Delta logo]()
$728
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/193:34 pm -
2 stops22h 10m
Wed 1/275:00 pm -
2 stops19h 26m
Deal found 10/26![American Airlines logo]()
$781
This Booking.com deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:10 pm -
3 stops24h 30m
Wed 1/274:05 pm -
2 stops16h 05m
Deal found 10/26![Multiple Airlines logo]()
$1,503
This Mytrip deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/264:10 pm -
3 stops26h 30m
Thu 12/36:13 pm -
3 stops30h 07m
Deal found 10/29![Multiple Airlines logo]()
$1,369
One-way flights from Panama City to St. LouisSearch for one-way flight options from Panama City to St. Louis. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
Search for one-way flight options from Panama City to St. Louis. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/202:26 pm -
1 stop9h 16m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![American Airlines logo]()
$342
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/298:00 am -
1 stop7h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![Delta logo]()
$373
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/294:41 pm -
2 stops19h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/26![United Airlines logo]()
$379
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3011:35 am -
1 stop11h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![United Airlines logo]()
$431
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/314:41 pm -
2 stops19h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/26![United Airlines logo]()
$437
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/84:41 pm -
2 stops23h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![United Airlines logo]()
$442
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/48:00 am -
1 stop26h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/26![Delta logo]()
$517
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/18:55 am -
1 stop14h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/26![United Airlines logo]()
$599
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/18:00 am -
1 stop9h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![Delta logo]()
$620
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/42:41 pm -
2 stops22h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/26![American Airlines logo]()
$790
Find flight deals from Panama City to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $609 (Delta) |
One-way from | $342 (American Airlines) |
Popular in | June |
Cheapest in | March |
Average price | $711 |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CitySt. Louis
PTY Panama City Tocumen Intl - STL Lambert-St Louis
PTYSTL
Panama City Tocumen Intl
Wed 1/20
2:26 pm-10:42 pm
1 stop9h 16m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$342
Quickest round-trip
Panama CitySt. Louis
PTY Panama City Tocumen Intl - STL Lambert-St Louis
PTYSTL
Panama City Tocumen Intl
Tue 12/29
8:00 am-2:43 pm
1 stop7h 43m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$373
Panama CitySt. Louis
PTY Panama City Tocumen Intl - STL Lambert-St Louis
PTYSTL
Panama City Tocumen Intl
Wed 12/30
11:35 am-10:30 pm
1 stop11h 55m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$431
Panama CitySt. Louis
PTY Panama City Tocumen Intl - STL Lambert-St Louis
PTYSTL
Panama City Tocumen Intl
Thu 12/31
4:41 pm-10:42 am
2 stops19h 01m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$437
Panama CitySt. Louis
PTY Panama City Tocumen Intl - STL Lambert-St Louis
PTYSTL
Panama City Tocumen Intl
Tue 12/8
4:41 pm-4:50 pm
1 stop25h 09m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$442
Panama CitySt. Louis
PTY Panama City Tocumen Intl - STL Lambert-St Louis
PTYSTL
Panama City Tocumen Intl
Mon 1/25
3:29 pm-11:26 pm
1 stop8h 57m
Lambert-St Louis
Sun 1/31
6:00 am-2:04 pm
1 stop7h 04m
$609
Panama CitySt. Louis
PTY Panama City Tocumen Intl - STL Lambert-St Louis
PTYSTL
Panama City Tocumen Intl
Mon 1/25
4:55 pm-2:05 pm
2 stops22h 10m
Lambert-St Louis
Sun 1/31
6:06 pm-1:26 pm
1 stop18h 20m
$645
Panama CitySt. Louis
PTY Panama City Tocumen Intl - STL Lambert-St Louis
PTYSTL
Panama City Tocumen Intl
Wed 1/27
4:41 pm-9:31 am
1 stop17h 50m
Lambert-St Louis
Sun 1/31
6:45 pm-5:12 pm
2 stops21h 27m
$693
Panama CitySt. Louis
PTY Panama City Tocumen Intl - STL Lambert-St Louis
PTYSTL
Panama City Tocumen Intl
Wed 1/20
10:05 am-3:26 pm
3 stops30h 21m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$869
Panama CitySt. Louis
PTY Panama City Tocumen Intl - STL Lambert-St Louis
PTYSTL
Panama City Tocumen Intl
Sat 1/2
8:00 am-2:44 pm
1 stop7h 44m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$1,075
Showing 1-10 of 11 resultsSorted by cheapest first
Compare providers for flights from Panama City to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to St. Louis in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.
PTY-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to St. Louis
What is the cheapest month to book a flight from Panama City to St. Louis?
Currently, March is the cheapest month in which you can book a flight from Panama City to St. Louis (average of $360). Flying from Panama City to St. Louis in June is currently the most expensive (average of $976). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Panama City to St. Louis?
Airfare is below average for this route at the moment.
Panama City to St. Louis flights typically cost between $641 and $741 in January.The cheapest round-trip price found within the last 5 days was $609 on Delta (Jan 25-Jan 31).
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated October 30, 2026.
Read through reviews of airlines operating flights from Panama City to St. Louis, such as United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.7
Comfort
7.3
Crew
8.1
Food
6.7
Overall
7.3
Entertainment
7.1
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Boarding
7.7
Comfort
7.3
Crew
8.1
Food
6.7
Overall
7.3
Entertainment
7.1
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Related info for your journey
Find useful and relevant information for your journey from Panama City to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsFairview Heights
O'Fallon
Fenton
Swansea
Eureka
Wentzville
Maryland Heights
Chesterfield
Collinsville
Edwardsville
Glencoe
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Panama City and St. Louis flights
Browse other Panama City and St. Louis flight options. Last updated on October 30, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on October 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 30, 2026.
Top airline flying from Panama City to St. Louis
Discover the top airline that operate flights from Panama City to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$229 | Average$761 | FlexibilityNo cancel fee | On-time69% |