$322+ Cheap flights from Panama City (PTY) to St. Louis (STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/15. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STL
Jul 15 — Jul 221
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to St. Louis
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Cheapest flights from Panama City to St. LouisExplore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 15, 2026.
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 15, 2026.
This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/69:45 am
PTY
- STL
1 stop13h 59m
United Airlines
Tue 8/187:00 am
STL
- PTY
1 stop12h 31m
United Airlines
Deal found 6/13![United Airlines logo]()
$675
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/69:45 am
PTY
- STL
1 stop13h 53m
United Airlines
Thu 9/107:00 am
STL
- PTY
1 stop12h 31m
United Airlines
Deal found 6/11![United Airlines logo]()
$699
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1410:25 am
PTY
- STL
2 stops22h 32m
Multiple Airlines
Fri 7/174:57 pm
STL
- PTY
1 stop27h 37m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$700
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/269:45 am
PTY
- STL
1 stop13h 59m
United Airlines
Sun 8/25:59 pm
STL
- PTY
2 stops22h 13m
United Airlines
Deal found 6/11![United Airlines logo]()
$720
This American Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/52:43 pm
PTY
- STL
2 stops22h 54m
American Airlines
Sun 11/81:52 pm
STL
- PTY
2 stops22h 44m
American Airlines
Deal found 6/15![American Airlines logo]()
$727
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/39:48 pm
PTY
- STL
2 stops43h 49m
Multiple Airlines
Sat 7/114:57 pm
STL
- PTY
1 stop27h 37m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$734
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/147:55 am
PTY
- STL
2 stops13h 31m
United Airlines
Fri 7/177:05 pm
STL
- PTY
2 stops19h 09m
United Airlines
Deal found 6/14![United Airlines logo]()
$741
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/211:14 pm
PTY
- STL
1 stop21h 10m
American Airlines
Sat 8/811:35 am
STL
- PTY
1 stop25h 04m
American Airlines
Deal found 6/10![American Airlines logo]()
$742
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/297:55 am
PTY
- STL
1 stop12h 47m
United Airlines
Wed 7/86:14 am
STL
- PTY
1 stop9h 58m
United Airlines
Deal found 6/14![United Airlines logo]()
$752
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/39:48 pm
PTY
- STL
2 stops43h 49m
Multiple Airlines
Sun 7/126:34 pm
STL
- PTY
1 stop26h 00m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$757
Best flights from Panama City to St. LouisDiscover carefully curated flight deals from Panama City to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 15, 2026.
Discover carefully curated flight deals from Panama City to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 15, 2026.
This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/63:30 pm
PTY
- STL
2 stops19h 04m
United Airlines
Tue 8/1811:15 am
STL
- PTY
1 stop7h 22m
United Airlines
Deal found 6/13![United Airlines logo]()
$680
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/54:41 pm
PTY
- STL
2 stops18h 46m
United Airlines
Sun 11/87:30 am
STL
- PTY
1 stop11h 32m
United Airlines
Deal found 6/15![United Airlines logo]()
$699
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/63:30 pm
PTY
- STL
2 stops24h 08m
United Airlines
Thu 9/108:00 am
STL
- PTY
2 stops10h 37m
United Airlines
Deal found 6/15![United Airlines logo]()
$699
Last-minute flights from Panama City to St. LouisDiscover last-minute flight deals from Panama City to St. Louis. Data last updated June 15, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to St. Louis. Data last updated June 15, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/287:55 am
PTY
- STL
1 stop14h 50m
United Airlines
Thu 7/911:10 am
STL
- PTY
1 stop7h 27m
United Airlines
Deal found 6/14![United Airlines logo]()
$784
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/297:55 am
PTY
- STL
1 stop12h 47m
United Airlines
Mon 7/66:14 am
STL
- PTY
1 stop12h 23m
United Airlines
Deal found 6/14![United Airlines logo]()
$752
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/3010:55 pm
PTY
- STL
2 stops13h 16m
United Airlines
Sun 7/128:35 am
STL
- PTY
1 stop7h 37m
United Airlines
Deal found 6/14![United Airlines logo]()
$763
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/110:55 pm
PTY
- STL
2 stops16h 51m
United Airlines
Mon 7/67:05 pm
STL
- PTY
2 stops19h 09m
United Airlines
Deal found 6/14![United Airlines logo]()
$766
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/39:48 pm
PTY
- STL
2 stops43h 49m
Multiple Airlines
Sat 7/114:57 pm
STL
- PTY
1 stop27h 37m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$734
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/39:48 pm
PTY
- STL
2 stops43h 49m
Multiple Airlines
Sun 7/126:34 pm
STL
- PTY
1 stop26h 00m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$757
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1410:25 am
PTY
- STL
2 stops22h 32m
Multiple Airlines
Fri 7/174:57 pm
STL
- PTY
1 stop27h 37m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$700
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/147:55 am
PTY
- STL
2 stops13h 31m
United Airlines
Fri 7/177:05 pm
STL
- PTY
2 stops19h 09m
United Airlines
Deal found 6/14![United Airlines logo]()
$741
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/211:14 pm
PTY
- STL
1 stop21h 10m
American Airlines
Sat 8/811:35 am
STL
- PTY
1 stop25h 04m
American Airlines
Deal found 6/10![American Airlines logo]()
$742
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/269:45 am
PTY
- STL
1 stop13h 59m
United Airlines
Sun 8/25:59 pm
STL
- PTY
2 stops22h 13m
United Airlines
Deal found 6/11![United Airlines logo]()
$720
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/261:14 pm
PTY
- STL
2 stops23h 27m
American Airlines
Sun 8/25:13 pm
STL
- PTY
2 stops19h 01m
American Airlines
Deal found 6/12![American Airlines logo]()
$771
One-way flights from Panama City to St. LouisSearch for one-way flight options from Panama City to St. Louis. Find affordable one-way fares based on user searches. Data last updated June 15, 2026.
Search for one-way flight options from Panama City to St. Louis. Find affordable one-way fares based on user searches. Data last updated June 15, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/154:25 am
PTY
- STL
3 stops37h 12m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$322
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/25:30 am
PTY
- STL
3 stops36h 00m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$326
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/33:10 pm
PTY
- STL
3 stops41h 42m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$336
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/45:30 am
PTY
- STL
3 stops27h 22m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$338
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/153:30 pm
PTY
- STL
1 stop26h 12m
United Airlines
Deal found 6/14![United Airlines logo]()
$388
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/33:30 pm
PTY
- STL
2 stops24h 08m
United Airlines
Deal found 6/14![United Airlines logo]()
$393
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/43:30 pm
PTY
- STL
1 stop22h 43m
United Airlines
Deal found 6/14![United Airlines logo]()
$420
This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/2010:55 pm
PTY
- STL
1 stop17h 12m
United Airlines
Deal found 6/13![United Airlines logo]()
$484
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/213:30 pm
PTY
- STL
1 stop26h 12m
United Airlines
Deal found 6/15![United Airlines logo]()
$485
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/214:25 am
PTY
- STL
3 stops38h 28m
Multiple Airlines
Deal found 6/13![Multiple Airlines logo]()
$537
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/204:25 am
PTY
- STL
3 stops38h 28m
Multiple Airlines
Deal found 6/13![Multiple Airlines logo]()
$558
Find flight deals from Panama City to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 15, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $675 (United Airlines) |
One-way from | $322 (Kiwi.com) |
Popular in | May |
Cheapest in | March |
Average price | $773 |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 15, 2026.
Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Panama CitySt. Louis
PTY - STL
PTYSTL
Panama City Tocumen Intl
Thu 8/6
3:30 pm-10:34 am
2 stops19h 04m
Lambert-St Louis
Tue 8/18
11:15 am-6:37 pm
1 stop7h 22m
$680
Panama CitySt. Louis
PTY - STL
PTYSTL
Panama City Tocumen Intl
Thu 11/5
4:41 pm-10:27 am
2 stops18h 46m
Lambert-St Louis
Sun 11/8
7:30 am-8:02 pm
1 stop11h 32m
$699
Panama CitySt. Louis
PTY - STL
PTYSTL
Panama City Tocumen Intl
Sun 9/6
3:30 pm-3:38 pm
2 stops24h 08m
Lambert-St Louis
Thu 9/10
8:00 am-6:37 pm
2 stops10h 37m
$699
Cheapest one-way
Quickest one-way
Panama CitySt. Louis
PTY - STL
PTYSTL
Panama City Tocumen Intl
Thu 9/3
10:00 am-6:06 pm
1 stop8h 06m
$388
Panama CitySt. Louis
PTY - STL
PTYSTL
Panama City Tocumen Intl
Wed 7/15
3:30 pm-12:11 pm
2 stops20h 41m
$388
Panama CitySt. Louis
PTY - STL
PTYSTL
Panama City Tocumen Intl
Wed 9/2
10:25 am-5:30 pm
2 stops31h 05m
$389
Panama CitySt. Louis
PTY - STL
PTYSTL
Panama City Tocumen Intl
Fri 9/4
3:30 pm-2:13 pm
1 stop22h 43m
$420
Panama CitySt. Louis
PTY - STL
PTYSTL
Panama City Tocumen Intl
Sun 6/21
3:30 pm-5:42 pm
1 stop26h 12m
$484
Panama CitySt. Louis
PTY - STL
PTYSTL
Panama City Tocumen Intl
Sat 6/20
10:55 pm-4:07 pm
1 stop17h 12m
$484
Panama CitySt. Louis
PTY - STL
PTYSTL
Panama City Tocumen Intl
Sun 6/21
5:30 am-6:18 pm
3 stops36h 48m
$588
Sorted by cheapest first
- Most accurate provider: When it comes to deals on Panama City-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.
PTY-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to St. Louis
What is the cheapest month to book a flight from Panama City to St. Louis?
Currently, March is the cheapest month in which you can book a flight from Panama City to St. Louis (average of $360). Flying from Panama City to St. Louis in May is currently the most expensive (average of $825). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Panama City to St. Louis?
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated June 15, 2026.
Read through reviews of airlines operating flights from Panama City to St. Louis, such as United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.3
Crew
8.1
Food
6.6
Overall
7.4
Entertainment
7.1
Boarding
7.7
Reviews
1 / 20
4.0
OkayDynasty,May 2026
LAX - EWR
Comfort
7.3
Crew
8.1
Food
6.6
Overall
7.4
Entertainment
7.1
Boarding
7.7
Reviews
1 / 20
4.0
OkayDynasty,May 2026
LAX - EWR
Related info for your journey
Find useful and relevant information for your journey from Panama City to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Eureka
Maryland Heights
Collinsville
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Complete your trip
Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Panama City to St. Louis, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Panama City and St. Louis flights
Browse other Panama City and St. Louis flight options. Last updated on June 15, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on June 15, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 15, 2026.
Top airline flying from Panama City to St. Louis
Discover the top airline that operate flights from Panama City to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 15, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$229 | Average$678 | FlexibilityNo cancel fee | On-time69% |