$341+ Cheap flights from Panama City (PTY) to St. Louis (STL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/15. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STL
Oct 11 — Oct 181
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Panama City to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to St. Louis
Cheapest
Best
Last-minute
One-way
Cheapest flights from Panama City to St. LouisExplore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2026.
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2026.
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/38:55 am -
1 stop30h 18m
Mon 11/96:00 am -
1 stop13h 02m
Deal found 9/10![United Airlines logo]()
$615
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2310:00 am -
2 stops14h 24m
Fri 11/278:30 am -
1 stop10h 08m
Deal found 9/8![United Airlines logo]()
$655
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/253:34 pm -
1 stop19h 03m
Thu 1/286:02 pm -
1 stop18h 34m
Deal found 9/11![American Airlines logo]()
$669
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/273:34 pm -
2 stops21h 47m
Wed 1/276:02 pm -
1 stop20h 53m
Deal found 9/11![American Airlines logo]()
$679
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:41 pm -
1 stop23h 32m
Sat 11/77:30 am -
2 stops11h 08m
Deal found 9/10![United Airlines logo]()
$694
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/213:34 pm -
1 stop19h 33m
Thu 1/216:02 pm -
1 stop20h 53m
Deal found 9/11![American Airlines logo]()
$710
This Ovago deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2710:00 am -
1 stop13h 00m
Wed 1/278:50 am -
1 stop7h 22m
Deal found 9/11![Copa Airlines logo]()
$735
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/410:00 am -
1 stop27h 10m
Sat 10/104:30 pm -
2 stops28h 01m
Deal found 9/10![Multiple Airlines logo]()
$736
Best flights from Panama City to St. LouisDiscover carefully curated flight deals from Panama City to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 11, 2026.
Discover carefully curated flight deals from Panama City to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 11, 2026.
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/34:41 pm -
2 stops22h 53m
Mon 11/96:15 am -
1 stop7h 30m
Deal found 9/8![United Airlines logo]()
$615
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2310:00 am -
2 stops14h 24m
Fri 11/278:30 am -
1 stop10h 08m
Deal found 9/8![United Airlines logo]()
$655
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:41 pm -
1 stop23h 32m
Sat 11/77:30 am -
2 stops11h 08m
Deal found 9/8![United Airlines logo]()
$694
Last-minute flights from Panama City to St. LouisDiscover last-minute flight deals from Panama City to St. Louis. Data last updated September 11, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to St. Louis. Data last updated September 11, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/232:23 pm -
1 stop9h 19m
Sun 9/2710:05 am -
1 stop26h 53m
Deal found 9/7![Delta logo]()
$745
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/231:16 pm -
2 stops11h 11m
Sun 9/275:00 am -
1 stop7h 16m
Deal found 9/7![American Airlines logo]()
$783
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/410:00 am -
1 stop27h 10m
Sat 10/104:30 pm -
2 stops28h 01m
Deal found 9/10![Multiple Airlines logo]()
$736
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/143:30 pm -
2 stops19h 18m
Sun 10/185:36 pm -
2 stops20h 38m
Deal found 9/6![United Airlines logo]()
$757
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/243:30 pm -
1 stop22h 43m
Sat 10/316:09 am -
1 stop12h 53m
Deal found 9/9![United Airlines logo]()
$758
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/262:24 pm -
1 stop9h 30m
Sun 11/16:00 am -
1 stop6h 59m
Deal found 9/10![Delta logo]()
$755
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:41 pm -
1 stop26h 09m
Sat 11/711:00 am -
1 stop7h 38m
Deal found 9/10![United Airlines logo]()
$694
One-way flights from Panama City to St. LouisSearch for one-way flight options from Panama City to St. Louis. Find affordable one-way fares based on user searches. Data last updated September 11, 2026.
Search for one-way flight options from Panama City to St. Louis. Find affordable one-way fares based on user searches. Data last updated September 11, 2026.
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/154:41 pm -
2 stops22h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![United Airlines logo]()
$341
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:55 am -
1 stop14h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![United Airlines logo]()
$345
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:02 pm -
2 stops20h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![American Airlines logo]()
$350
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/193:25 pm -
1 stop27h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![Delta logo]()
$380
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/194:41 pm -
2 stops20h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![United Airlines logo]()
$391
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/282:24 pm -
1 stop9h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![Delta logo]()
$420
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:55 am -
2 stops15h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![United Airlines logo]()
$431
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/294:00 pm -
3 stops19h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$440
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/208:55 am -
2 stops15h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![United Airlines logo]()
$459
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/159:31 pm -
3 stops28h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$487
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2810:29 pm -
3 stops24h 47m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$498
Find flight deals from Panama City to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $615 (United Airlines) |
One-way from | $341 (United Airlines) |
Popular in | June |
Cheapest in | March |
Average price | $687 |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 11, 2026.
Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CitySt. Louis
PTY Panama City Tocumen Intl - STL Lambert-St Louis
PTYSTL
Panama City Tocumen Intl
Thu 10/29
3:41 pm-2:29 pm
2 stops22h 48m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$341
Panama CitySt. Louis
PTY Panama City Tocumen Intl - STL Lambert-St Louis
PTYSTL
Panama City Tocumen Intl
Tue 12/15
8:55 am-9:40 am
1 stop25h 45m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$341
Panama CitySt. Louis
PTY Panama City Tocumen Intl - STL Lambert-St Louis
PTYSTL
Panama City Tocumen Intl
Sun 12/20
8:00 am-10:09 pm
1 stop15h 09m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$380
Panama CitySt. Louis
PTY Panama City Tocumen Intl - STL Lambert-St Louis
PTYSTL
Panama City Tocumen Intl
Sat 12/19
3:25 pm-6:19 pm
1 stop27h 54m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$380
Quickest round-trip
Panama CitySt. Louis
PTY Panama City Tocumen Intl - STL Lambert-St Louis
PTYSTL
Panama City Tocumen Intl
Sun 12/20
8:55 am-10:30 pm
1 stop14h 35m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$380
Panama CitySt. Louis
PTY Panama City Tocumen Intl - STL Lambert-St Louis
PTYSTL
Panama City Tocumen Intl
Sat 12/19
4:41 pm-12:26 pm
2 stops20h 45m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$380
Panama CitySt. Louis
PTY Panama City Tocumen Intl - STL Lambert-St Louis
PTYSTL
Panama City Tocumen Intl
Tue 11/3
4:41 pm-2:34 pm
2 stops22h 53m
Lambert-St Louis
Mon 11/9
6:15 am-2:45 pm
1 stop7h 30m
$615
Panama CitySt. Louis
PTY Panama City Tocumen Intl - STL Lambert-St Louis
PTYSTL
Panama City Tocumen Intl
Mon 11/23
10:00 am-11:24 pm
2 stops14h 24m
Lambert-St Louis
Fri 11/27
8:30 am-7:38 pm
1 stop10h 08m
$655
Panama CitySt. Louis
PTY Panama City Tocumen Intl - STL Lambert-St Louis
PTYSTL
Panama City Tocumen Intl
Sat 10/31
3:41 pm-3:13 pm
1 stop23h 32m
Lambert-St Louis
Sat 11/7
7:30 am-7:38 pm
2 stops11h 08m
$694
Sorted by cheapest first
- Most accurate provider: When it comes to deals on Panama City-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.
PTY-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to St. Louis
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated September 11, 2026.
Read through reviews of airlines operating flights from Panama City to St. Louis, such as United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.7
Overall
7.4
Entertainment
7.1
Comfort
7.3
Food
6.7
Crew
8.1
Reviews
1 / 20
4.0
OkayChris,Aug 2026
MIA - ORD
Boarding
7.7
Overall
7.4
Entertainment
7.1
Comfort
7.3
Food
6.7
Crew
8.1
Reviews
1 / 20
4.0
OkayChris,Aug 2026
MIA - ORD
Related info for your journey
Find useful and relevant information for your journey from Panama City to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsFairview Heights
O'Fallon
Fenton
Swansea
Eureka
Maryland Heights
Collinsville
Wentzville
Edwardsville
Glencoe
Chesterfield
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Panama City
Popular flights
St. Louis flight routes
Alternative routes for Panama City to St. Louis
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Panama City to St. Louis by cabin class
Find flights from Panama City to St. Louis, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Panama City and St. Louis flights
Browse other Panama City and St. Louis flight options. Last updated on September 11, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on September 11, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 11, 2026.
Top airline flying from Panama City to St. Louis
Discover the top airline that operate flights from Panama City to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$229 | Average$752 | FlexibilityNo cancel fee | On-time69% |