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St. Louis

$311+ Cheap flights from Panama City (PTY) to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/22. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STL
Jun 10 — Jun 171
Wed 6/10
Wed 6/17
1 adult, Economy
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Cheap flight deals from Panama City to St. Louis

Cheapest flights from Panama City to St. Louis
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 11, 2026.

This Delta deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/62:28 pm
PTY
-
STL
1 stop9h 09m
Delta
Thu 9/106:00 am
STL
-
PTY
1 stop6h 56m
Delta
Deal found 5/11$656
This American Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/22:43 pm
PTY
-
STL
1 stop8h 49m
American Airlines
Wed 11/116:17 pm
STL
-
PTY
2 stops18h 19m
American Airlines
Deal found 5/10$659
This United Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/28:55 am
PTY
-
STL
1 stop14h 11m
United Airlines
Wed 11/116:30 am
STL
-
PTY
1 stop12h 32m
United Airlines
Deal found 5/10$665
This United Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/63:30 pm
PTY
-
STL
1 stop18h 40m
United Airlines
Thu 9/106:00 am
STL
-
PTY
2 stops12h 37m
United Airlines
Deal found 5/11$677
This United Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/283:30 pm
PTY
-
STL
2 stops20h 33m
United Airlines
Mon 8/3112:27 pm
STL
-
PTY
1 stop15h 37m
United Airlines
Deal found 5/7$691
This United Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/183:30 pm
PTY
-
STL
2 stops17h 09m
United Airlines
Mon 6/225:29 pm
STL
-
PTY
2 stops22h 43m
United Airlines
Deal found 5/8$699
This Delta deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:15 pm
PTY
-
STL
1 stop9h 44m
Delta
Mon 6/86:00 am
STL
-
PTY
1 stop7h 09m
Delta
Deal found 5/8$717
This United Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/13:30 pm
PTY
-
STL
2 stops20h 41m
United Airlines
Mon 6/86:00 am
STL
-
PTY
1 stop13h 31m
United Airlines
Deal found 5/11$720
This American Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/11:14 pm
PTY
-
STL
2 stops21h 23m
American Airlines
Mon 6/87:20 pm
STL
-
PTY
2 stops16h 53m
American Airlines
Deal found 5/9$740
This United Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/283:30 pm
PTY
-
STL
2 stops24h 16m
United Airlines
Sun 5/317:05 pm
STL
-
PTY
2 stops21h 07m
United Airlines
Deal found 5/10$741

Find flight deals from Panama City to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$656
(Delta)

One-way from

$311
(Kiwi.com)

Popular in

May

Cheapest in

March

Average price

$766
Provider with most accurate pricing for Panama City Tocumen Intl-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Lambert-St Louis flights.
Search Deals
From Panama City Tocumen Intl to Lambert-St Louis
Search Deals
One-way flight from Panama City Tocumen Intl to Lambert-St Louis
Search Deals
High demand for flights, 6% potential price rise
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 11, 2026.
Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sun 9/6

2:28 pm-11:37 pm

1 stop9h 09m

Lambert-St Louis

Thu 9/10

6:00 am-12:56 pm

1 stop6h 56m

$656

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sun 9/6

3:30 pm-3:38 pm

2 stops24h 08m

Lambert-St Louis

Thu 9/10

6:00 am-7:31 pm

2 stops13h 31m

$677

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Fri 8/28

3:30 pm-12:03 pm

2 stops20h 33m

Lambert-St Louis

Mon 8/31

7:00 am-7:31 pm

1 stop12h 31m

$691

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 6/1

3:30 pm-12:11 pm

2 stops20h 41m

Lambert-St Louis

Mon 6/8

6:00 am-7:31 pm

1 stop13h 31m

$720

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 6/1

1:14 pm-10:37 am

2 stops21h 23m

Lambert-St Louis

Mon 6/8

7:20 pm-12:13 pm

2 stops16h 53m

$740
Cheapest one-way

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Wed 7/22

9:48 pm-5:37 pm

2 stops19h 49m

$311

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 7/20

9:48 pm-5:37 pm

2 stops19h 49m

$347

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 7/23

2:24 pm-8:19 am

1 stop17h 55m

$366

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 7/20

10:55 pm-11:36 pm

1 stop24h 41m

$382

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 7/25

2:27 pm-8:19 am

1 stop17h 52m

$398

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/8

Showing 1-10 of 13 resultsSorted by cheapest first
1
2
  • Most accurate provider: When it comes to deals on Panama City-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to St. Louis

What is the cheapest month to book a flight from Panama City to St. Louis?

Currently, March is the cheapest month in which you can book a flight from Panama City to St. Louis (average of $360). Flying from Panama City to St. Louis in May is currently the most expensive (average of $766). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Panama City to St. Louis?

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated May 11, 2026.
Read through reviews of airlines operating flights from Panama City to St. Louis, such as United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,699 reviews

Comfort

7.3

Entertainment

7.1

Crew

8.1

Food

6.6

Overall

7.4

Boarding

7.7

Reviews

1 / 20
8.0
Excellent

Anonymous,Apr 2026

DFW - EWR

The flight was on time. Crew was friendly. Will fly again. The seats was comfortable.
United Airlines
7.4
Good
9,699 reviews
United Airlines
7.4
Good
9,699 reviews

Comfort

7.3

Entertainment

7.1

Crew

8.1

Food

6.6

Overall

7.4

Boarding

7.7

Reviews

1 / 20
8.0
Excellent

Anonymous,Apr 2026

DFW - EWR

The flight was on time. Crew was friendly. Will fly again. The seats was comfortable.

Related info for your journey

Find useful and relevant information for your journey from Panama City to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to St. Louis?

    Airlines like United Airlines fly from Panama City to St. Louis in about 14h 11m. The time it takes to get you to your destination can typically vary by up to . There are 2159 mi between Panama City and St. Louis.

  • What is the cheapest airline to fly from Panama City to St. Louis round-trip?

    Our cheapest airline available from Panama City to St. Louis is United Airlines. Our recent data shows that you can find tickets from as low as $229 on this airline. You may be able to fly from Panama City to St. Louis for 59% less than the average price by searching for this airline.

  • Can I find deals for flights from Panama City to St. Louis that include hotel bookings?

    Yes. In addition to deals on Panama City to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to St. Louis.

  • Can I find deals for business class flights from Panama City to St. Louis?

    Yes. Cheapflights offers flight deals from Panama City to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to St. Louis?

    Currently, March is the cheapest month in which you can book a flight from Panama City to St. Louis (average of $360). Flying from Panama City to St. Louis in May is currently the most expensive (average of $766). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Panama City to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to Kansas City flights

Top airline flying from Panama City to St. Louis

Discover the top airline that operate flights from Panama City to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 11, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$252Average$684FlexibilityNo cancel feeOn-time69%

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