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Find cheap American Airlines flights to Knoxville

RDU — TYS
Aug 26 — Sep 21
Wed 8/26
Wed 9/2
1 adult, Economy
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Find American Airlines flight deals to Knoxville

Cheapest American Airlines flights from USA to Knoxville
Explore the most affordable American Airlines flight options available from USA to Knoxville. Find the lowest fares with prices last updated on July 27, 2026.

This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:34 pm
DFW
-
TYS
Nonstop2h 19m
American Airlines
Thu 9/36:03 am
TYS
-
DFW
Nonstop2h 29m
American Airlines
Deal found 7/26$237
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/265:01 am
DFW
-
TYS
1 stop7h 30m
American Airlines
Sat 8/291:53 pm
TYS
-
DFW
Nonstop2h 27m
American Airlines
Deal found 7/23$243
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/167:29 pm
ORD
-
TYS
Nonstop1h 48m
American Airlines
Sat 8/227:59 am
TYS
-
ORD
Nonstop2h 11m
American Airlines
Deal found 7/22$249

Flights to Knoxville with American Airlines at a glance

Find detailed information about American Airlines flights from USA to Knoxville. Explore the options provided by American Airlines to plan your journey from USA to Knoxville. Data last updated July 27, 2026.

Popular in

June

Cheapest in

August

Average price

$402

Round-trip from

$237

One-way from

$119

Good one-way deal

$243 or less
Highest demand for flights to Knoxville with American Airlines; 7% potential price increase.
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Best time to find cheap flights to Knoxville with American Airlines; 1% potential price drop.
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Average price for flights to Knoxville with American Airlines (round-trip).
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American Airlines
  • American Airlines
  • 9/30-10/6
  • Nonstop
  • 5h 05m total
  • USA to Knoxville
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American Airlines
  • American Airlines
  • 10/3
  • Nonstop
  • 2h 15m total
  • USA to Knoxville
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Price to beat on a one-way flight from the United States to Knoxville with American Airlines.
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Cheapflights Insights

Find cheap American Airlines flights to Knoxville

How long is the flight to Knoxville with American Airlines?

On average, American Airlines flights from the United States to Knoxville take 1 hour 48 minutes. Flights to Knoxville from other popular cities in the United States will vary in length. Below are a few examples of popular routes and their flight times.

American Airlines weekly flight availability to Knoxville

The most flights to Knoxville operated by American Airlines are scheduled on a Thursday (27 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (24 on average).

When is the best time to book a flight to Knoxville with American Airlines?

The best time to book a flight to Knoxville with American Airlines is 70 days before departure. On average, fares are higher if you book 6 days before departure.

When is the cheapest time to fly to Knoxville with American Airlines?

Users looking for the cheapest American Airlines fares to Knoxville should consider flying on Saturday evenings, when prices are typically cheapest. Budget-minded travellers will want to avoid Sunday evenings, when prices are usually at their highest.

FAQs about flights to Knoxville with American Airlines

  • Which airport do American Airlines flights arrive at when travelling to Knoxville?

    American Airlines flights on this route tend to land at Knoxville McGhee Tyson Airport.

  • Is American Airlines the cheapest airline for a flight to Knoxville?

    Flight prices will depend on many factors like date, time and cabin class so it is worth comparing flights before booking. Based on Cheapflights data the cheapest average return price for flights to Knoxville tends to be with Avelo Airlines.

  • Are there alternative airlines other than American Airlines that fly to Knoxville?

    Allegiant Air, Delta and United Airlines all fly to Knoxville and offer an alternative to American Airlines.

  • How much is a flight to Knoxville with American Airlines?

    The average price for a return flight with American Airlines is $444; with a one-way flight around $285.

See more FAQs

Reviews of American Airlines

See what Cheapflights users have to say about their American Airlines experience.
American Airlines
7.1
Good
10,000 reviews
Overview

Food

6.4

Crew

7.9

Comfort

7.2

Boarding

7.5

Entertainment

6.8

Popular American Airlines flights

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