$152+ Cheap flights from Portland, ME to Knoxville (PWM - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/19. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — TYS
Oct 8 — Oct 151
Round-trip
1 adult, Economy
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Find cheap flights from Portland to Knoxville with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Portland to KnoxvilleExplore the most affordable flight options available from Portland to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 8, 2026.
Explore the most affordable flight options available from Portland to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 8, 2026.
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:27 am -
1 stop6h 57m
Wed 12/26:17 pm -
1 stop5h 17m
Deal found 9/3![Delta logo]()
$303
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/265:15 am -
1 stop7h 15m
Thu 12/31:00 pm -
2 stops8h 45m
Deal found 9/3![Southwest logo]()
$308
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:00 am -
1 stop5h 28m
Mon 11/167:06 am -
1 stop4h 52m
Deal found 9/3![Delta logo]()
$316
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1311:10 am -
2 stops9h 20m
Mon 11/167:55 am -
1 stop4h 15m
Deal found 9/3![Southwest logo]()
$321
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1910:54 am -
1 stop28h 57m
Tue 11/246:30 am -
1 stop26h 38m
Deal found 9/3![Multiple Airlines logo]()
$326
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/232:05 pm -
1 stop6h 04m
Tue 11/244:00 pm -
1 stop7h 31m
Deal found 9/3![Delta logo]()
$345
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:30 am -
1 stop5h 03m
Sun 10/256:05 pm -
1 stop5h 31m
Deal found 9/4![American Airlines logo]()
$370
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/115:30 am -
1 stop6h 00m
Sun 11/154:30 pm -
1 stop6h 51m
Deal found 9/4![United Airlines logo]()
$385
Best flights from Portland to KnoxvilleDiscover carefully curated flight deals from Portland to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 8, 2026.
Discover carefully curated flight deals from Portland to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 8, 2026.
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/265:15 am -
1 stop7h 15m
Thu 12/31:00 pm -
2 stops8h 45m
Deal found 9/3![Southwest logo]()
$308
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:00 am -
1 stop5h 28m
Mon 11/167:06 am -
1 stop4h 52m
Deal found 9/3![Delta logo]()
$316
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:49 am -
1 stop7h 03m
Fri 10/304:30 pm -
1 stop6h 51m
Deal found 9/7![United Airlines logo]()
$391
This Delta deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:28 am -
1 stop4h 34m
Sat 10/242:38 pm -
1 stop6h 22m
Deal found 9/4![Delta logo]()
$426
This Southwest deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:40 am -
2 stops11h 00m
Sun 10/257:15 am -
1 stop5h 15m
Deal found 9/4![Southwest logo]()
$435
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:30 am -
1 stop4h 34m
Fri 10/95:15 pm -
1 stop6h 03m
Deal found 9/7![Delta logo]()
$446
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:35 pm -
1 stop19h 13m
Mon 11/164:30 pm -
2 stops7h 29m
Deal found 9/3![United Airlines logo]()
$504
Last-minute flights from Portland to KnoxvilleDiscover last-minute flight deals from Portland to Knoxville. Data last updated September 8, 2026 and is based on user searches.
Discover last-minute flight deals from Portland to Knoxville. Data last updated September 8, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/231:05 pm -
1 stop6h 50m
Wed 9/3012:45 pm -
2 stops8h 30m
Deal found 9/3![Southwest logo]()
$428
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:00 am -
1 stop4h 38m
Fri 10/96:05 pm -
1 stop5h 54m
Deal found 9/3![American Airlines logo]()
$316
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:28 am -
1 stop4h 34m
Sat 10/244:11 pm -
1 stop4h 49m
Deal found 9/3![Delta logo]()
$391
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:30 am -
1 stop5h 03m
Sun 10/256:05 pm -
1 stop5h 31m
Deal found 9/4![American Airlines logo]()
$370
This Southwest deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:40 am -
2 stops11h 00m
Sun 10/257:15 am -
1 stop5h 15m
Deal found 9/4![Southwest logo]()
$435
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:49 am -
1 stop7h 03m
Fri 10/304:30 pm -
1 stop6h 51m
Deal found 9/3![United Airlines logo]()
$396
One-way flights from Portland to KnoxvilleSearch for one-way flight options from Portland to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 8, 2026.
Search for one-way flight options from Portland to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 8, 2026.
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:00 am -
1 stop5h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![American Airlines logo]()
$152
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:00 am -
2 stops8h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/5![United Airlines logo]()
$182
This Southwest deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:40 am -
2 stops11h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/5![Southwest logo]()
$219
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/195:50 am -
2 stops8h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![United Airlines logo]()
$239
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/77:00 am -
3 stops40h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/5![Multiple Airlines logo]()
$334
Find flight deals from Portland to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Portland (PWM) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 8, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $303 (Delta) |
One-way from | $152 (American Airlines) |
Popular in | December |
Cheapest in | January |
Average price | $378 |
Cheapflights Fare Finder
Customize your flight search to find flights from Portland to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 8, 2026.
Use the filters below to find and compare flights from Portland to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
PortlandKnoxville
PWM Portland - TYS Knoxville McGhee Tyson
PWMTYS
Portland
Thu 11/19
6:00 am-11:14 am
1 stop5h 14m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$152
PortlandKnoxville
PWM Portland - TYS Knoxville McGhee Tyson
PWMTYS
Portland
Wed 10/7
6:00 am-2:42 pm
2 stops8h 42m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$182
PortlandKnoxville
PWM Portland - TYS Knoxville McGhee Tyson
PWMTYS
Portland
Wed 10/7
5:40 am-4:40 pm
2 stops11h 00m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$219
PortlandKnoxville
PWM Portland - TYS Knoxville McGhee Tyson
PWMTYS
Portland
Thu 11/19
5:50 am-2:48 pm
2 stops8h 58m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$239
PortlandKnoxville
PWM Portland - TYS Knoxville McGhee Tyson
PWMTYS
Portland
Thu 11/26
5:15 am-12:30 pm
1 stop7h 15m
Knoxville McGhee Tyson
Thu 12/3
1:00 pm-9:45 pm
2 stops8h 45m
$308
PortlandKnoxville
PWM Portland - TYS Knoxville McGhee Tyson
PWMTYS
Portland
Fri 11/13
6:00 am-11:28 am
1 stop5h 28m
Knoxville McGhee Tyson
Mon 11/16
7:06 am-11:58 am
1 stop4h 52m
$316
PortlandKnoxville
PWM Portland - TYS Knoxville McGhee Tyson
PWMTYS
Portland
Wed 10/28
8:49 am-3:52 pm
1 stop7h 03m
Knoxville McGhee Tyson
Fri 10/30
4:30 pm-11:21 pm
1 stop6h 51m
$391
PortlandKnoxville
PWM Portland - TYS Knoxville McGhee Tyson
PWMTYS
Portland
Mon 10/19
6:28 am-11:02 am
1 stop4h 34m
Knoxville McGhee Tyson
Sat 10/24
2:38 pm-9:00 pm
1 stop6h 22m
$426
PortlandKnoxville
PWM Portland - TYS Knoxville McGhee Tyson
PWMTYS
Portland
Wed 10/21
5:40 am-4:40 pm
2 stops11h 00m
Knoxville McGhee Tyson
Sun 10/25
7:15 am-12:30 pm
1 stop5h 15m
$435
PortlandKnoxville
PWM Portland - TYS Knoxville McGhee Tyson
PWMTYS
Portland
Thu 10/1
6:30 am-11:04 am
1 stop4h 34m
Knoxville McGhee Tyson
Fri 10/9
5:15 pm-11:18 pm
1 stop6h 03m
$446
Showing 1-10 of 11 resultsSorted by cheapest first
Compare providers for flights from Portland to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Portland to Knoxville in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Portland, Maine-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Portland, Maine-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Portland, Maine-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Portland, Maine-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Portland, Maine-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Portland to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Portland with our price prediction graph.
PWM-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Portland to Knoxville
What is the cheapest month to book a flight from Portland, Maine to Knoxville?
Currently, January is the cheapest month in which you can book a flight from Portland, Maine to Knoxville (average of $285). Flying from Portland, Maine to Knoxville in December is currently the most expensive (average of $724). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Portland, Maine to Knoxville?
Airfare is below average for this route at the moment.
Portland, Maine to Knoxville flights typically cost between $325 and $458 in November.The cheapest round-trip price found within the last 5 days was $303 on Delta (Nov 26-Dec 2).
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 8, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from Portland to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Related info for your journey
Find useful and relevant information for your journey from Portland to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 8, 2026.
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Top 4 airlines flying from Portland to Knoxville
Discover the top 4 airlines that operate flights from Portland to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 8, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$278 | Average$433 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$278 | Average$372 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$279 | Average$408 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$293 | Average$423 | FlexibilityNo cancel fee | On-time63% |