$308+ Cheap flights from Rochester, MN to Knoxville (RST - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/12. Fares are subject to change and may not be available on all flights or dates of travel.
RST — TYS
Oct 7 — Oct 141
Round-trip
1 adult, Economy
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Find cheap flights from Rochester to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Rochester to Knoxville
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Cheapest flights from Rochester to KnoxvilleExplore the most affordable flight options available from Rochester to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 7, 2026.
Explore the most affordable flight options available from Rochester to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 7, 2026.
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1012:34 pm -
1 stop5h 12m
Mon 11/168:52 pm -
1 stop4h 07m
Deal found 9/7![American Airlines logo]()
$308
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/127:02 am -
2 stops9h 38m
Tue 11/176:01 am -
2 stops10h 59m
Deal found 9/5![American Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/184:16 pm -
1 stop5h 55m
Wed 11/256:30 pm -
1 stop5h 18m
Deal found 9/7![Delta logo]()
$328
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/194:22 pm -
1 stop5h 40m
Wed 10/285:40 am -
2 stops6h 03m
Deal found 9/6![Delta logo]()
$334
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/194:22 pm -
2 stops6h 36m
Tue 10/275:40 am -
2 stops6h 03m
Deal found 9/6![Delta logo]()
$339
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/24:24 pm -
1 stop6h 00m
Wed 12/95:40 am -
2 stops11h 03m
Deal found 9/6![Delta logo]()
$349
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:00 am -
2 stops11h 33m
Wed 12/97:00 am -
2 stops9h 43m
Deal found 9/6![Delta logo]()
$354
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/24:24 pm -
1 stop6h 00m
Sat 12/127:06 am -
2 stops9h 37m
Deal found 9/6![Delta logo]()
$379
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/114:20 pm -
1 stop6h 27m
Sun 11/157:52 am -
1 stop5h 11m
Deal found 9/6![American Airlines logo]()
$383
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2411:23 am -
2 stops7h 26m
Thu 10/295:40 am -
2 stops6h 03m
Deal found 9/6![Delta logo]()
$384
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/201:02 pm -
1 stop4h 18m
Wed 10/2811:35 am -
1 stop5h 11m
Deal found 9/6![American Airlines logo]()
$388
Best flights from Rochester to KnoxvilleDiscover carefully curated flight deals from Rochester to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 7, 2026.
Discover carefully curated flight deals from Rochester to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 7, 2026.
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/124:20 pm -
1 stop6h 27m
Tue 11/1711:33 am -
1 stop5h 27m
Deal found 9/5![American Airlines logo]()
$308
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/74:25 pm -
1 stop5h 37m
Fri 1/158:47 am -
2 stops7h 56m
Deal found 9/3![Delta logo]()
$314
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/74:28 pm -
1 stop6h 22m
Fri 1/157:49 am -
1 stop5h 14m
Deal found 9/5![American Airlines logo]()
$308
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/44:24 pm -
1 stop6h 00m
Thu 12/107:06 am -
2 stops9h 37m
Deal found 9/6![Delta logo]()
$334
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:00 am -
2 stops11h 47m
Fri 10/305:40 am -
2 stops6h 03m
Deal found 9/6![Delta logo]()
$339
Last-minute flights from Rochester to KnoxvilleDiscover last-minute flight deals from Rochester to Knoxville. Data last updated September 7, 2026 and is based on user searches.
Discover last-minute flight deals from Rochester to Knoxville. Data last updated September 7, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/135:50 am -
1 stop5h 40m
Sat 9/198:15 pm -
1 stop4h 44m
Deal found 9/7![American Airlines logo]()
$413
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/194:22 pm -
1 stop5h 40m
Wed 10/285:40 am -
2 stops6h 03m
Deal found 9/6![Delta logo]()
$334
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/194:22 pm -
2 stops6h 36m
Tue 10/275:40 am -
2 stops6h 03m
Deal found 9/6![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/194:27 pm -
1 stop6h 32m
Sat 10/246:55 pm -
1 stop6h 12m
Deal found 9/6![American Airlines logo]()
$403
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/194:22 pm -
1 stop5h 40m
Mon 10/267:45 pm -
2 stops15h 58m
Deal found 9/6![Delta logo]()
$428
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/201:02 pm -
1 stop4h 18m
Wed 10/2811:35 am -
1 stop5h 11m
Deal found 9/6![American Airlines logo]()
$388
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/204:27 pm -
1 stop6h 32m
Mon 10/266:55 pm -
1 stop6h 12m
Deal found 9/6![American Airlines logo]()
$463
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2411:23 am -
2 stops7h 26m
Thu 10/295:40 am -
2 stops6h 03m
Deal found 9/6![Delta logo]()
$384
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/244:27 pm -
2 stops6h 28m
Wed 10/2811:35 am -
1 stop5h 11m
Deal found 9/6![American Airlines logo]()
$394
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/244:27 pm -
2 stops6h 28m
Mon 10/266:55 pm -
1 stop6h 12m
Deal found 9/6![American Airlines logo]()
$469
Find flight deals from Rochester to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Rochester (RST) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 7, 2026.
Most accurate provider | Expedia 1 star |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $308 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Rochester to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 7, 2026.
Use the filters below to find and compare flights from Rochester to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
RochesterKnoxville
RST Rochester - TYS Knoxville McGhee Tyson
RSTTYS
Rochester
Thu 11/12
4:20 pm-11:47 pm
1 stop6h 27m
Knoxville McGhee Tyson
Tue 11/17
11:33 am-4:00 pm
1 stop5h 27m
$308
Quickest round-trip
RochesterKnoxville
RST Rochester - TYS Knoxville McGhee Tyson
RSTTYS
Rochester
Thu 1/7
4:28 pm-11:50 pm
1 stop6h 22m
Knoxville McGhee Tyson
Fri 1/15
7:49 am-12:03 pm
1 stop5h 14m
$308
RochesterKnoxville
RST Rochester - TYS Knoxville McGhee Tyson
RSTTYS
Rochester
Thu 1/7
4:25 pm-11:02 pm
1 stop5h 37m
Knoxville McGhee Tyson
Fri 1/15
8:47 am-3:43 pm
2 stops7h 56m
$314
RochesterKnoxville
RST Rochester - TYS Knoxville McGhee Tyson
RSTTYS
Rochester
Fri 12/4
4:24 pm-11:24 pm
1 stop6h 00m
Knoxville McGhee Tyson
Thu 12/10
7:06 am-3:43 pm
2 stops9h 37m
$334
RochesterKnoxville
RST Rochester - TYS Knoxville McGhee Tyson
RSTTYS
Rochester
Tue 10/20
6:00 am-6:47 pm
2 stops11h 47m
Knoxville McGhee Tyson
Fri 10/30
5:40 am-10:43 am
2 stops6h 03m
$339
Sorted by cheapest first
- Most accurate provider: When it comes to deals on Rochester, Minnesota-Knoxville flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Rochester, Minnesota-Knoxville flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Rochester, Minnesota-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Rochester, Minnesota-Knoxville flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Rochester, Minnesota-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Rochester to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Rochester with our price prediction graph.
RST-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 7, 2026.
Get a feel of what it's like to fly with American Airlines from Rochester to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.2
Crew
7.9
Food
6.4
Boarding
7.5
Entertainment
6.8
Overall
7.1
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Comfort
7.2
Crew
7.9
Food
6.4
Boarding
7.5
Entertainment
6.8
Overall
7.1
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from Rochester to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
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Top airline flying from Rochester to Knoxville
Discover the top airline that operate flights from Rochester to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 7, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$314 | Average$398 | FlexibilityNo cancel fee | On-time71% |