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Knoxville

$273+ Cheap flights from Rochester to Knoxville (RST - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/18. Fares are subject to change and may not be available on all flights or dates of travel.
RST — TYS
May 27 — Jun 31
Wed 5/27
Wed 6/3
1 adult, Economy
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Cheap flight deals from Rochester to Knoxville

Cheapest flights from Rochester to Knoxville
Explore the most affordable flight options available from Rochester to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 27, 2026.

This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/244:25 pm
RST
-
TYS
1 stop5h 37m
Delta
Wed 12/307:55 am
TYS
-
RST
1 stop4h 08m
Delta
Deal found 4/25$332
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/246:30 am
RST
-
TYS
1 stop6h 57m
American Airlines
Wed 12/304:22 pm
TYS
-
RST
2 stops8h 23m
American Airlines
Deal found 4/24$379
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/175:45 am
RST
-
TYS
1 stop4h 12m
American Airlines
Wed 5/207:53 am
TYS
-
RST
1 stop4h 13m
American Airlines
Deal found 4/23$546
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/174:45 pm
RST
-
TYS
1 stop5h 12m
Delta
Wed 5/205:40 am
TYS
-
RST
2 stops6h 13m
Delta
Deal found 4/23$552
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1811:36 am
RST
-
TYS
2 stops11h 19m
American Airlines
Thu 5/2111:01 am
TYS
-
RST
2 stops8h 11m
American Airlines
Deal found 4/25$557

Find flight deals from Rochester to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Rochester (RST) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$546
(American Airlines)

One-way from

$273
(United Airlines)
Provider with most accurate pricing for Rochester-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Rochester-Knoxville McGhee Tyson flights.
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From Rochester to Knoxville McGhee Tyson
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One-way flight from Rochester to Knoxville McGhee Tyson
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Rochester to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 27, 2026.
Use the filters below to find and compare flights from Rochester to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Mon 5/18

5:45 am-10:57 am

1 stop4h 12m

Knoxville McGhee Tyson

Thu 5/21

6:20 pm-12:05 am

1 stop6h 45m

$546
Quickest round-trip

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Sun 5/17

5:45 am-10:57 am

1 stop4h 12m

Knoxville McGhee Tyson

Wed 5/20

7:53 am-11:06 am

1 stop4h 13m

$546

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Sun 5/17

4:45 pm-10:57 pm

1 stop5h 12m

Knoxville McGhee Tyson

Wed 5/20

5:40 am-10:53 am

2 stops6h 13m

$552

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Thu 7/23

5:46 am-11:05 am

1 stop4h 19m

Knoxville McGhee Tyson

Mon 7/27

6:56 am-10:28 am

1 stop4h 32m

$563

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Thu 7/23

11:34 am-9:38 pm

2 stops9h 04m

Knoxville McGhee Tyson

Mon 7/27

5:25 pm-10:42 pm

2 stops6h 17m

$569

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Thu 7/23

3:19 pm-8:39 pm

1 stop4h 20m

Knoxville McGhee Tyson

Mon 7/27

7:19 pm-5:21 pm

2 stops23h 02m

$587
Cheapest one-way

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Thu 6/18

4:46 pm-11:01 pm

1 stop5h 15m

$273
Quickest one-way

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Thu 6/18

7:05 pm-12:30 am

1 stop4h 25m

$273

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Thu 6/18

10:27 am-6:07 pm

1 stop6h 40m

$273

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/23

Sorted by cheapest first

Compare providers for flights from Rochester to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Rochester to Knoxville in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Rochester-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Rochester-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Rochester-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Rochester-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Rochester-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Rochester to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Rochester with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 27, 2026.
Get a feel of what it's like to fly with American Airlines from Rochester to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,668 reviews

Comfort

7.2

Boarding

7.5

Entertainment

6.9

Food

6.4

Crew

7.9

Overall

7.1

Reviews

1 / 20
4.0
Okay

Elizabeth,Mar 2026

ORD - MIA

Staff was rude and flight attendants 2 out of 3 looked like they had just been thru a hurricane.
American Airlines
7.1
Good
11,668 reviews
American Airlines
7.1
Good
11,668 reviews

Comfort

7.2

Boarding

7.5

Entertainment

6.9

Food

6.4

Crew

7.9

Overall

7.1

Reviews

1 / 20
4.0
Okay

Elizabeth,Mar 2026

ORD - MIA

Staff was rude and flight attendants 2 out of 3 looked like they had just been thru a hurricane.

Related info for your journey

Find useful and relevant information for your journey from Rochester to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Rochester to Knoxville?

    For as low as $546, American Airlines can have you in Knoxville from Rochester in 4h 12m. Airlines will cover a distance of 718 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Rochester to Knoxville round-trip?

    Our cheapest airline available from Rochester to Knoxville is American Airlines. Our recent data shows that you can find tickets from as low as $314 on this airline.

  • Can I find deals for flights from Rochester to Knoxville that include hotel bookings?

    Yes. In addition to deals on Rochester to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Rochester to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Rochester to Knoxville.

  • Can I find deals for business class flights from Rochester to Knoxville?

    Yes. Cheapflights offers flight deals from Rochester to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Oak Ridge

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Rochester to Knoxville

Discover the top airline that operate flights from Rochester to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$314Average$384FlexibilityNo cancel feeOn-time71%

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