$348+ Cheap flights from Rochester, MN to Knoxville (RST - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/7. Fares are subject to change and may not be available on all flights or dates of travel.
RST — TYS
Nov 25 — Dec 21
Round-trip
1 adult, Economy
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Find cheap flights from Rochester to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Rochester to Knoxville
Cheapest
Best
Last-minute
Cheapest flights from Rochester to KnoxvilleExplore the most affordable flight options available from Rochester to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 26, 2026.
Explore the most affordable flight options available from Rochester to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 26, 2026.
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/154:24 pm -
1 stop6h 00m
Sat 12/196:00 am -
2 stops10h 43m
Deal found 10/21![Delta logo]()
$354
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1611:15 am -
2 stops10h 02m
Sat 12/196:00 am -
2 stops10h 43m
Deal found 10/21![Delta logo]()
$374
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/104:30 pm -
1 stop5h 21m
Sat 11/1411:33 am -
1 stop5h 17m
Deal found 10/25![American Airlines logo]()
$378
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1512:52 pm -
1 stop5h 13m
Sat 12/198:48 pm -
1 stop4h 26m
Deal found 10/21![American Airlines logo]()
$393
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/164:16 pm -
1 stop6h 10m
Sun 12/208:48 pm -
1 stop4h 26m
Deal found 10/21![American Airlines logo]()
$408
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/246:07 am -
2 stops10h 22m
Wed 12/308:48 pm -
1 stop4h 26m
Deal found 10/21![American Airlines logo]()
$414
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/291:02 pm -
1 stop4h 18m
Mon 11/28:52 pm -
1 stop4h 07m
Deal found 10/23![American Airlines logo]()
$453
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/217:02 am -
1 stop15h 48m
Fri 11/278:50 pm -
1 stop4h 16m
Deal found 10/24![American Airlines logo]()
$463
Best flights from Rochester to KnoxvilleDiscover carefully curated flight deals from Rochester to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 26, 2026.
Discover carefully curated flight deals from Rochester to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 26, 2026.
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/74:35 pm -
1 stop6h 53m
Sun 1/108:51 pm -
1 stop4h 29m
Deal found 10/22![American Airlines logo]()
$348
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/44:35 pm -
1 stop6h 53m
Sun 2/77:50 am -
1 stop5h 14m
Deal found 10/21![American Airlines logo]()
$348
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/712:36 pm -
1 stop5h 31m
Fri 1/1512:02 pm -
1 stop5h 03m
Deal found 10/25![American Airlines logo]()
$348
Last-minute flights from Rochester to KnoxvilleDiscover last-minute flight deals from Rochester to Knoxville. Data last updated October 26, 2026 and is based on user searches.
Discover last-minute flight deals from Rochester to Knoxville. Data last updated October 26, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/291:02 pm -
1 stop4h 18m
Mon 11/28:52 pm -
1 stop4h 07m
Deal found 10/23![American Airlines logo]()
$453
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/104:30 pm -
1 stop5h 21m
Sat 11/1411:33 am -
1 stop5h 17m
Deal found 10/25![American Airlines logo]()
$378
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/217:02 am -
1 stop15h 48m
Fri 11/278:50 pm -
1 stop4h 16m
Deal found 10/24![American Airlines logo]()
$463
Find flight deals from Rochester to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Rochester (RST) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 26, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $348 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Rochester to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 26, 2026.
Use the filters below to find and compare flights from Rochester to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
RochesterKnoxville
RST Rochester - TYS Knoxville McGhee Tyson
RSTTYS
Rochester
Thu 1/7
4:35 pm-12:28 am
1 stop6h 53m
Knoxville McGhee Tyson
Sun 1/10
8:51 pm-12:20 am
1 stop4h 29m
$348
RochesterKnoxville
RST Rochester - TYS Knoxville McGhee Tyson
RSTTYS
Rochester
Thu 2/4
4:35 pm-12:28 am
1 stop6h 53m
Knoxville McGhee Tyson
Sun 2/7
7:50 am-12:04 pm
1 stop5h 14m
$348
Quickest round-trip
RochesterKnoxville
RST Rochester - TYS Knoxville McGhee Tyson
RSTTYS
Rochester
Thu 1/7
12:36 pm-7:07 pm
1 stop5h 31m
Knoxville McGhee Tyson
Fri 1/15
12:02 pm-4:05 pm
1 stop5h 03m
$348
Sorted by cheapest first
Compare providers for flights from Rochester to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Rochester to Knoxville in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Rochester, Minnesota-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Rochester, Minnesota-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Rochester, Minnesota-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Rochester, Minnesota-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Rochester, Minnesota-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Rochester to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Rochester with our price prediction graph.
RST-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated October 26, 2026.
Get a feel of what it's like to fly with American Airlines from Rochester to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.1
Entertainment
6.8
Food
6.4
Crew
7.9
Boarding
7.4
Overall
7.0
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Comfort
7.1
Entertainment
6.8
Food
6.4
Crew
7.9
Boarding
7.4
Overall
7.0
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from Rochester to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Newport
Bryson City
Murphy
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Top airline flying from Rochester to Knoxville
Discover the top airline that operate flights from Rochester to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$314 | Average$398 | FlexibilityNo cancel fee | On-time71% |