$266+ Cheap flights from Sioux Falls to Knoxville (FSD - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/20. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — TYS
Nov 24 — Dec 11
Round-trip
1 adult, Economy
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Find cheap flights from Sioux Falls to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Sioux Falls to Knoxville
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Cheapest flights from Sioux Falls to KnoxvilleExplore the most affordable flight options available from Sioux Falls to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
Explore the most affordable flight options available from Sioux Falls to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:25 am -
1 stop7h 30m
Wed 11/254:00 pm -
1 stop4h 56m
Deal found 10/20![Delta logo]()
$337
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/43:19 pm -
1 stop7h 27m
Mon 12/78:46 pm -
1 stop5h 00m
Deal found 10/21![American Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/33:19 pm -
1 stop7h 27m
Mon 12/78:46 pm -
1 stop5h 00m
Deal found 10/23![American Airlines logo]()
$349
This Delta deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:27 am -
2 stops9h 03m
Mon 12/74:01 pm -
1 stop5h 07m
Deal found 10/24![Delta logo]()
$359
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/71:20 pm -
1 stop8h 12m
Wed 11/115:40 pm -
1 stop6h 49m
Deal found 10/23![United Airlines logo]()
$369
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/205:44 am -
1 stop7h 21m
Tue 1/55:30 am -
1 stop6h 54m
Deal found 10/21![American Airlines logo]()
$407
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/71:08 pm -
2 stops9h 51m
Wed 11/112:13 pm -
2 stops11h 16m
Deal found 10/23![American Airlines logo]()
$416
Best flights from Sioux Falls to KnoxvilleDiscover carefully curated flight deals from Sioux Falls to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
Discover carefully curated flight deals from Sioux Falls to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/201:45 pm -
1 stop7h 35m
Tue 4/274:25 pm -
1 stop7h 31m
Deal found 10/20![United Airlines logo]()
$335
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:25 am -
1 stop7h 30m
Wed 11/254:00 pm -
1 stop4h 56m
Deal found 10/20![Delta logo]()
$337
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/43:19 pm -
1 stop7h 27m
Mon 12/78:46 pm -
1 stop5h 00m
Deal found 10/20![American Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/33:19 pm -
1 stop7h 27m
Mon 12/78:46 pm -
1 stop5h 00m
Deal found 10/20![American Airlines logo]()
$339
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/71:20 pm -
1 stop8h 12m
Wed 11/115:40 pm -
1 stop6h 49m
Deal found 10/23![United Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/118:15 am -
2 stops11h 25m
Sun 2/144:00 pm -
1 stop4h 41m
Deal found 10/24![Delta logo]()
$389
This Delta deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:27 am -
2 stops9h 03m
Mon 12/74:01 pm -
1 stop5h 07m
Deal found 10/23![Delta logo]()
$434
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/911:19 am -
1 stop4h 35m
Wed 1/131:55 pm -
1 stop5h 43m
Deal found 10/24![United Airlines logo]()
$435
This Delta deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2012:40 pm -
2 stops10h 10m
Tue 1/52:35 pm -
1 stop6h 12m
Deal found 10/24![Delta logo]()
$434
Last-minute flights from Sioux Falls to KnoxvilleDiscover last-minute flight deals from Sioux Falls to Knoxville. Data last updated October 25, 2026 and is based on user searches.
Discover last-minute flight deals from Sioux Falls to Knoxville. Data last updated October 25, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:50 am -
1 stop4h 24m
Sat 10/246:03 pm -
1 stop6h 08m
Deal found 10/21![United Airlines logo]()
$437
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:20 am -
1 stop6h 47m
Mon 11/28:52 pm -
1 stop4h 37m
Deal found 10/21![American Airlines logo]()
$429
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/309:59 am -
1 stop28h 03m
Sun 11/17:00 am -
1 stop12h 44m
Deal found 10/21![Allegiant Air logo]()
$439
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3011:00 am -
1 stop4h 27m
Sun 11/111:45 am -
2 stops9h 10m
Deal found 10/21![Delta logo]()
$459
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/71:20 pm -
1 stop8h 12m
Wed 11/115:40 pm -
1 stop6h 49m
Deal found 10/23![United Airlines logo]()
$369
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/71:08 pm -
2 stops9h 51m
Wed 11/112:13 pm -
2 stops11h 16m
Deal found 10/23![American Airlines logo]()
$416
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:25 am -
1 stop7h 30m
Wed 11/254:00 pm -
1 stop4h 56m
Deal found 10/20![Delta logo]()
$337
One-way flights from Sioux Falls to KnoxvilleSearch for one-way flight options from Sioux Falls to Knoxville. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
Search for one-way flight options from Sioux Falls to Knoxville. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/206:38 pm -
2 stops50h 26m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/24![Multiple Airlines logo]()
$266
This Kiwi.com deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/205:32 pm -
1 stop24h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/24![Allegiant Air logo]()
$326
Find flight deals from Sioux Falls to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Sioux Falls (FSD) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 25, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $335 (American Airlines) |
One-way from | $305 (Kiwi.com) |
Popular in | July |
Cheapest in | April |
Average price | $381 |
Cheapflights Fare Finder
Customize your flight search to find flights from Sioux Falls to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
Use the filters below to find and compare flights from Sioux Falls to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Sioux FallsKnoxville
FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson
FSDTYS
Sioux Falls Joe Foss Field
Fri 11/20
6:38 pm-10:04 pm
2 stops50h 26m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$266
Sioux FallsKnoxville
FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson
FSDTYS
Sioux Falls Joe Foss Field
Tue 4/20
1:45 pm-10:20 pm
1 stop7h 35m
Knoxville McGhee Tyson
Tue 4/27
4:25 pm-10:56 pm
1 stop7h 31m
$335
Sioux FallsKnoxville
FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson
FSDTYS
Sioux Falls Joe Foss Field
Wed 11/18
5:25 am-1:55 pm
1 stop7h 30m
Knoxville McGhee Tyson
Wed 11/25
4:00 pm-7:56 pm
1 stop4h 56m
$337
Sioux FallsKnoxville
FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson
FSDTYS
Sioux Falls Joe Foss Field
Fri 12/4
3:19 pm-11:46 pm
1 stop7h 27m
Knoxville McGhee Tyson
Mon 12/7
8:46 pm-12:46 am
1 stop5h 00m
$339
Sioux FallsKnoxville
FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson
FSDTYS
Sioux Falls Joe Foss Field
Thu 12/3
3:19 pm-11:46 pm
1 stop7h 27m
Knoxville McGhee Tyson
Mon 12/7
8:46 pm-12:46 am
1 stop5h 00m
$339
Sioux FallsKnoxville
FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson
FSDTYS
Sioux Falls Joe Foss Field
Sat 11/7
1:20 pm-10:32 pm
1 stop8h 12m
Knoxville McGhee Tyson
Wed 11/11
5:40 pm-11:29 pm
1 stop6h 49m
$369
Sioux FallsKnoxville
FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson
FSDTYS
Sioux Falls Joe Foss Field
Thu 2/11
8:15 am-8:40 pm
2 stops11h 25m
Knoxville McGhee Tyson
Sun 2/14
4:00 pm-7:41 pm
1 stop4h 41m
$389
Sioux FallsKnoxville
FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson
FSDTYS
Sioux Falls Joe Foss Field
Thu 12/3
8:27 am-6:30 pm
2 stops9h 03m
Knoxville McGhee Tyson
Mon 12/7
4:01 pm-8:08 pm
1 stop5h 07m
$434
Sioux FallsKnoxville
FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson
FSDTYS
Sioux Falls Joe Foss Field
Sun 12/20
12:40 pm-11:50 pm
2 stops10h 10m
Knoxville McGhee Tyson
Tue 1/5
2:35 pm-7:47 pm
1 stop6h 12m
$434
Quickest round-trip
Sioux FallsKnoxville
FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson
FSDTYS
Sioux Falls Joe Foss Field
Sat 1/9
11:19 am-4:54 pm
1 stop4h 35m
Knoxville McGhee Tyson
Wed 1/13
1:55 pm-6:38 pm
1 stop5h 43m
$435
Sorted by cheapest first
Compare providers for flights from Sioux Falls to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Sioux Falls to Knoxville in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Sioux Falls-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Sioux Falls-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Sioux Falls-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Sioux Falls-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Sioux Falls-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Sioux Falls to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Sioux Falls with our price prediction graph.
FSD-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated October 25, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAmerican Airlines from Sioux Falls to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Crew
8.5
Entertainment
7.8
Boarding
8.1
Food
7.2
Overall
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Comfort
7.8
Crew
8.5
Entertainment
7.8
Boarding
8.1
Food
7.2
Overall
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Comfort
7.8
Crew
8.5
Entertainment
7.8
Boarding
8.1
Food
7.2
Overall
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Comfort
7.8
Crew
8.5
Entertainment
7.8
Boarding
8.1
Food
7.2
Overall
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Related info for your journey
Find useful and relevant information for your journey from Sioux Falls to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Newport
Bryson City
Murphy
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 25, 2026.
Sioux Falls and Knoxville flights
Browse other Sioux Falls and Knoxville flight options. Last updated on October 25, 2026.
Other flights from Sioux Falls
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Popular flight searches
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Top 3 airlines flying from Sioux Falls to Knoxville
Discover the top 3 airlines that operate flights from Sioux Falls to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$268 | Average$354 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$274 | Average$451 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$304 | Average$456 | FlexibilityNo cancel fee | On-time69% |