$246+ Cheap flights from Sioux Falls to Knoxville (FSD - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/28. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — TYS
Oct 8 — Oct 151
Round-trip
1 adult, Economy
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Find cheap flights from Sioux Falls to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Sioux Falls to Knoxville
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Best
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Cheapest flights from Sioux Falls to KnoxvilleExplore the most affordable flight options available from Sioux Falls to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 8, 2026.
Explore the most affordable flight options available from Sioux Falls to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 8, 2026.
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/296:00 am -
1 stop7h 05m
Tue 1/55:30 am -
1 stop7h 17m
Deal found 9/5![American Airlines logo]()
$315
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:30 am -
1 stop6h 28m
Tue 10/64:11 pm -
1 stop4h 44m
Deal found 9/8![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/33:03 pm -
1 stop4h 46m
Sat 10/1010:42 am -
2 stops10h 58m
Deal found 9/5![United Airlines logo]()
$342
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:00 am -
1 stop6h 53m
Sat 9/2611:20 am -
1 stop7h 51m
Deal found 9/7![American Airlines logo]()
$349
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:33 pm -
1 stop8h 11m
Sat 10/315:03 pm -
1 stop7h 41m
Deal found 9/4![United Airlines logo]()
$352
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:56 pm -
2 stops8h 54m
Tue 10/66:55 pm -
1 stop6h 46m
Deal found 9/7![American Airlines logo]()
$404
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/212:56 pm -
2 stops8h 54m
Tue 10/612:41 pm -
2 stops9h 32m
Deal found 9/8![American Airlines logo]()
$409
Best flights from Sioux Falls to KnoxvilleDiscover carefully curated flight deals from Sioux Falls to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 8, 2026.
Discover carefully curated flight deals from Sioux Falls to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 8, 2026.
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:30 am -
1 stop6h 28m
Tue 10/64:11 pm -
1 stop4h 44m
Deal found 9/8![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:33 pm -
1 stop8h 11m
Sat 10/315:03 pm -
1 stop7h 41m
Deal found 9/4![United Airlines logo]()
$352
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:56 pm -
1 stop6h 56m
Tue 10/610:10 am -
2 stops12h 03m
Deal found 9/8![American Airlines logo]()
$404
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/910:00 am -
1 stop6h 03m
Wed 1/136:40 am -
1 stop5h 00m
Deal found 9/7![United Airlines logo]()
$415
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/24:28 pm -
1 stop5h 46m
Tue 10/64:11 pm -
1 stop4h 44m
Deal found 9/8![Delta logo]()
$418
Last-minute flights from Sioux Falls to KnoxvilleDiscover last-minute flight deals from Sioux Falls to Knoxville. Data last updated September 8, 2026 and is based on user searches.
Discover last-minute flight deals from Sioux Falls to Knoxville. Data last updated September 8, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:33 pm -
1 stop8h 11m
Sat 10/315:03 pm -
1 stop7h 41m
Deal found 9/4![United Airlines logo]()
$352
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:00 am -
1 stop6h 53m
Sat 9/2611:20 am -
1 stop7h 51m
Deal found 9/7![American Airlines logo]()
$349
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/212:56 pm -
2 stops8h 54m
Tue 10/612:41 pm -
2 stops9h 32m
Deal found 9/8![American Airlines logo]()
$409
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/24:28 pm -
1 stop5h 46m
Tue 10/64:11 pm -
1 stop4h 44m
Deal found 9/8![Delta logo]()
$418
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:30 am -
1 stop6h 28m
Tue 10/64:11 pm -
1 stop4h 44m
Deal found 9/8![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected ” under the list of providers to see comparable flight deals.
Sat 10/33:03 pm -
1 stop4h 46m
Sat 10/1010:42 am -
2 stops10h 58m
Deal found 9/5![United Airlines logo]()
$342
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:56 pm -
2 stops8h 54m
Tue 10/66:55 pm -
1 stop6h 46m
Deal found 9/7![American Airlines logo]()
$404
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/31:46 pm -
1 stop7h 28m
Tue 10/64:53 pm -
1 stop7h 51m
Deal found 9/5![United Airlines logo]()
$417
One-way flights from Sioux Falls to KnoxvilleSearch for one-way flight options from Sioux Falls to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 8, 2026.
Search for one-way flight options from Sioux Falls to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 8, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/288:52 pm -
3 stops40h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Multiple Airlines logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:55 am -
2 stops10h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Allegiant Air logo]()
$264
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/283:03 pm -
1 stop4h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![United Airlines logo]()
$284
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:00 am -
1 stop7h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![American Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:00 am -
2 stops9h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![United Airlines logo]()
$384
Find flight deals from Sioux Falls to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Sioux Falls (FSD) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 8, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $315 (American Airlines) |
One-way from | $246 (Kiwi.com) |
Popular in | July |
Cheapest in | April |
Average price | $468 |
Cheapflights Fare Finder
Customize your flight search to find flights from Sioux Falls to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 8, 2026.
Use the filters below to find and compare flights from Sioux Falls to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Sioux FallsKnoxville
FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson
FSDTYS
Sioux Falls Joe Foss Field
Mon 9/28
8:52 pm-2:42 pm
3 stops40h 50m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$246
Sioux FallsKnoxville
FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson
FSDTYS
Sioux Falls Joe Foss Field
Mon 9/28
9:55 am-9:35 pm
2 stops10h 40m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$264
Quickest round-trip
Sioux FallsKnoxville
FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson
FSDTYS
Sioux Falls Joe Foss Field
Mon 9/28
3:03 pm-8:49 pm
1 stop4h 46m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$284
Sioux FallsKnoxville
FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson
FSDTYS
Sioux Falls Joe Foss Field
Sat 10/3
5:30 am-12:58 pm
1 stop6h 28m
Knoxville McGhee Tyson
Tue 10/6
4:11 pm-7:55 pm
1 stop4h 44m
$339
Sioux FallsKnoxville
FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson
FSDTYS
Sioux Falls Joe Foss Field
Sat 9/19
1:33 pm-10:44 pm
1 stop8h 11m
Knoxville McGhee Tyson
Sat 10/31
5:03 pm-11:44 pm
1 stop7h 41m
$352
Sioux FallsKnoxville
FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson
FSDTYS
Sioux Falls Joe Foss Field
Sat 9/19
6:00 am-2:29 pm
1 stop7h 29m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$369
Sioux FallsKnoxville
FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson
FSDTYS
Sioux Falls Joe Foss Field
Sat 9/19
6:00 am-4:58 pm
2 stops9h 58m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$384
Sioux FallsKnoxville
FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson
FSDTYS
Sioux Falls Joe Foss Field
Sat 10/3
12:56 pm-8:52 pm
1 stop6h 56m
Knoxville McGhee Tyson
Tue 10/6
10:10 am-9:13 pm
2 stops12h 03m
$404
Sioux FallsKnoxville
FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson
FSDTYS
Sioux Falls Joe Foss Field
Sat 1/9
10:00 am-5:03 pm
1 stop6h 03m
Knoxville McGhee Tyson
Wed 1/13
6:40 am-10:40 am
1 stop5h 00m
$415
Sioux FallsKnoxville
FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson
FSDTYS
Sioux Falls Joe Foss Field
Fri 10/2
4:28 pm-11:14 pm
1 stop5h 46m
Knoxville McGhee Tyson
Tue 10/6
4:11 pm-7:55 pm
1 stop4h 44m
$418
Sorted by cheapest first
Compare providers for flights from Sioux Falls to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Sioux Falls to Knoxville in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Sioux Falls-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Sioux Falls-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Sioux Falls-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Sioux Falls-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Sioux Falls-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Sioux Falls to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Sioux Falls with our price prediction graph.
FSD-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Sioux Falls to Knoxville
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 8, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAmerican Airlines from Sioux Falls to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Comfort
7.8
Boarding
8.1
Crew
8.5
Overall
7.8
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Food
7.2
Comfort
7.8
Boarding
8.1
Crew
8.5
Overall
7.8
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Food
7.2
Comfort
7.8
Boarding
8.1
Crew
8.5
Overall
7.8
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Food
7.2
Comfort
7.8
Boarding
8.1
Crew
8.5
Overall
7.8
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
Find useful and relevant information for your journey from Sioux Falls to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
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Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 8, 2026.
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Popular flight searches
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Top 3 airlines flying from Sioux Falls to Knoxville
Discover the top 3 airlines that operate flights from Sioux Falls to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 8, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$248 | Average$354 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$274 | Average$451 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$277 | Average$456 | FlexibilityNo cancel fee | On-time69% |