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$274+ Cheap flights from Sioux Falls to Knoxville (FSD - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/1. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — TYS
Jul 11 — Jul 181
Sat 7/11
Sat 7/18
1 adult, Economy
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Cheap flight deals from Sioux Falls to Knoxville

Cheapest flights from Sioux Falls to Knoxville
Explore the most affordable flight options available from Sioux Falls to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 11, 2026.

This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/15:34 pm
FSD
-
TYS
1 stop5h 17m
American Airlines
Sat 8/86:03 am
TYS
-
FSD
1 stop7h 14m
American Airlines
Deal found 6/10$305
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/307:02 am
FSD
-
TYS
1 stop4h 41m
American Airlines
Sat 7/45:37 am
TYS
-
FSD
1 stop7h 13m
American Airlines
Deal found 6/9$312
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/295:35 pm
FSD
-
TYS
1 stop5h 20m
American Airlines
Sat 7/46:19 pm
TYS
-
FSD
1 stop6h 59m
American Airlines
Deal found 6/8$319
This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/255:35 pm
FSD
-
TYS
1 stop5h 20m
American Airlines
Mon 6/295:33 pm
TYS
-
FSD
1 stop5h 44m
American Airlines
Deal found 6/6$334
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/56:36 pm
FSD
-
TYS
1 stop25h 39m
Allegiant Air
Sat 7/116:42 pm
TYS
-
FSD
2 stops39h 22m
Allegiant Air
Deal found 6/7$346
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/14:40 pm
FSD
-
TYS
1 stop6h 13m
American Airlines
Sat 7/46:22 am
TYS
-
FSD
1 stop7h 07m
American Airlines
Deal found 6/8$352
This Delta deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/34:28 pm
FSD
-
TYS
1 stop5h 32m
Delta
Mon 8/104:38 pm
TYS
-
FSD
1 stop4h 21m
Delta
Deal found 6/7$364

Find flight deals from Sioux Falls to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Sioux Falls (FSD) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$305
(American Airlines)

One-way from

$274
(American Airlines)

Popular in

March

Cheapest in

October

Average price

$485
Provider with most accurate pricing for Sioux Falls Joe Foss Field-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Sioux Falls Joe Foss Field-Knoxville McGhee Tyson flights.
Search Deals
From Sioux Falls Joe Foss Field to Knoxville McGhee Tyson
Search Deals
One-way flight from Sioux Falls Joe Foss Field to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($15 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Sioux Falls to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 11, 2026.
Use the filters below to find and compare flights from Sioux Falls to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 8/1

5:34 pm-11:51 pm

1 stop5h 17m

Knoxville McGhee Tyson

Sat 8/8

6:03 am-12:17 pm

1 stop7h 14m

$305

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Mon 8/3

8:22 am-4:41 pm

1 stop7h 19m

Knoxville McGhee Tyson

Mon 8/10

6:25 pm-10:51 pm

1 stop5h 26m

$364
Quickest round-trip

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Wed 7/8

5:34 pm-11:51 pm

1 stop5h 17m

Knoxville McGhee Tyson

Sat 7/11

5:31 pm-9:58 pm

1 stop5h 27m

$367

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 8/29

1:33 pm-10:29 pm

1 stop7h 56m

Knoxville McGhee Tyson

Wed 9/2

6:02 pm-11:22 pm

1 stop6h 20m

$385
Cheapest one-way
Quickest one-way

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Tue 8/11

12:06 pm-6:22 pm

1 stop5h 16m

$274

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Wed 7/1

5:12 am-2:49 pm

2 stops8h 37m

$387

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Tue 8/11

9:35 am-8:53 pm

3 stops10h 18m

$946

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/9

Sorted by cheapest first

Compare providers for flights from Sioux Falls to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Sioux Falls to Knoxville in June.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Sioux Falls-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Sioux Falls-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Sioux Falls-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Sioux Falls-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Sioux Falls-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Sioux Falls to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Sioux Falls with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Sioux Falls to Knoxville

What is the cheapest month to book a flight from Sioux Falls to Knoxville?

Currently, October is the cheapest month in which you can book a flight from Sioux Falls to Knoxville (average of $277). Flying from Sioux Falls to Knoxville in March is currently the most expensive (average of $593). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Sioux Falls to Knoxville?

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated June 11, 2026.
Peruse reviews from past customers who have flown with Delta and American Airlines from Sioux Falls to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,403 reviews

Overall

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Comfort

7.8

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional
Delta
7.9
Good
8,403 reviews
Delta
7.9
Good
8,403 reviews

Overall

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Comfort

7.8

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional
American Airlines
7.1
Good
11,642 reviews
Delta
7.9
Good
8,403 reviews

Overall

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Comfort

7.8

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

Related info for your journey

Find useful and relevant information for your journey from Sioux Falls to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Sioux Falls to Knoxville?

    Departing from Sioux Falls to Knoxville will take you 5h 17m. The distance from Sioux Falls to Knoxville is about 863 mi.

  • What are the cheapest airlines flying from Sioux Falls to Knoxville round-trip?

    Cheapflights users have booked flights from Sioux Falls to Knoxville round-trip from $248. Another airline that can offer you cheap pricing is Delta. American Airlines is priced at 36% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Sioux Falls to Knoxville that include hotel bookings?

    Yes. In addition to deals on Sioux Falls to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Sioux Falls to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Sioux Falls to Knoxville.

  • Can I find deals for business class flights from Sioux Falls to Knoxville?

    Yes. Cheapflights offers flight deals from Sioux Falls to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Sioux Falls to Knoxville?

    Currently, October is the cheapest month in which you can book a flight from Sioux Falls to Knoxville (average of $277). Flying from Sioux Falls to Knoxville in March is currently the most expensive (average of $593). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Oak Ridge

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Alternative routes for Sioux Falls to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Sioux Falls to Knoxville

Discover the top 2 airlines that operate flights from Sioux Falls to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 11, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$344FlexibilityNo cancel feeOn-time71%
DeltaCheapest$274Average$418FlexibilityNo cancel feeOn-timeN/A

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