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$212+ Cheap flights from Sioux Falls to Knoxville (FSD - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/14. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — TYS
Jan 3 — Jan 101
Sat 1/3
Sat 1/10
1 adult, Economy
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Cheap flight deals from Sioux Falls to Knoxville

Cheapest flights from Sioux Falls to Knoxville
Explore the most affordable flight options available from Sioux Falls to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 4, 2025.

This American Airlines deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/55:28 pmFSD - TYS
1 stop5h 31mAmerican Airlines
Fri 12/128:06 amTYS - FSD
1 stop6h 26mAmerican Airlines
Deal found 12/4$354
This United Airlines deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/166:00 amFSD - TYS
1 stop8h 07mUnited Airlines
Mon 12/224:04 pmTYS - FSD
1 stop8h 51mUnited Airlines
Deal found 12/4$389
This Kiwi.com deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1810:36 amFSD - TYS
1 stop22h 55mAllegiant Air
Mon 12/226:30 amTYS - FSD
1 stop28h 01mAllegiant Air
Deal found 12/3$396
This Kiwi.com deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/197:02 pmFSD - TYS
1 stop25h 32mAllegiant Air
Tue 12/236:23 pmTYS - FSD
1 stop15h 44mAllegiant Air
Deal found 12/4$428
This Mytrip deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1910:01 amFSD - TYS
2 stops10h 52mMultiple Airlines
Tue 12/236:23 pmTYS - FSD
1 stop15h 44mMultiple Airlines
Deal found 12/4$481
This American Airlines deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/207:11 amFSD - TYS
1 stop7h 40mAmerican Airlines
Wed 12/247:00 amTYS - FSD
2 stops9h 45mAmerican Airlines
Deal found 12/4$489
This United Airlines deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/206:16 pmFSD - TYS
1 stop27h 23mUnited Airlines
Wed 12/244:04 pmTYS - FSD
1 stop8h 51mUnited Airlines
Deal found 12/4$508
This Kiwi.com deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/75:55 pmFSD - TYS
1 stop26h 54mMultiple Airlines
Fri 12/125:56 pmTYS - FSD
2 stops48h 09mMultiple Airlines
Deal found 12/4$520

Find flight deals from Sioux Falls to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Sioux Falls (FSD) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 4, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$249
(United Airlines)

One-way from

$212
(Kiwi.com)

Popular in

January

Cheapest in

October

Average price

$354
Provider with most accurate pricing for Sioux Falls Joe Foss Field-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Sioux Falls Joe Foss Field-Knoxville McGhee Tyson flights.
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From Sioux Falls Joe Foss Field to Knoxville McGhee Tyson
Search Deals
One-way flight from Sioux Falls Joe Foss Field to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($62 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($20 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Sioux Falls to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
Use the filters below to find and compare flights from Sioux Falls to Knoxville that are best for you.

Fly from

Sioux Falls

Fly to

Knoxville

Route

Depart

Return

Price

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Fri 1/9

11:22 am-11:44 pm

2 stops11h 22m

Knoxville McGhee Tyson

Wed 1/14

11:10 am-2:36 pm

1 stop4h 26m

$254

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Fri 1/23

7:00 am-3:46 pm

1 stop7h 46m

Knoxville McGhee Tyson

Mon 1/26

12:15 pm-9:35 pm

2 stops10h 20m

$299

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 1/24

3:11 pm-8:52 pm

1 stop4h 41m

Knoxville McGhee Tyson

Wed 1/28

11:10 am-5:18 pm

1 stop7h 08m

$319

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Fri 1/23

9:00 am-8:52 pm

2 stops10h 52m

Knoxville McGhee Tyson

Mon 1/26

11:07 am-8:24 pm

2 stops10h 17m

$389

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Tue 12/16

6:00 am-3:07 pm

1 stop8h 07m

Knoxville McGhee Tyson

Mon 12/22

4:04 pm-11:55 pm

1 stop8h 51m

$389

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Thu 5/14

11:35 am-9:14 pm

1 stop8h 39m

$212

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Thu 5/14

5:15 am-3:06 pm

2 stops8h 51m

$445

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/4

Compare providers for flights from Sioux Falls to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Sioux Falls to Knoxville in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Sioux Falls-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Sioux Falls-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Sioux Falls-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Sioux Falls-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Sioux Falls-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Sioux Falls to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Sioux Falls with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Sioux Falls to Knoxville

What is the cheapest month to book a flight from Sioux Falls to Knoxville?

Currently, July is the cheapest month in which you can book a flight from Sioux Falls to Knoxville (average of $248). Flying from Sioux Falls to Knoxville in January is currently the most expensive (average of $387). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated December 4, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Sioux Falls to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,011 reviews

Comfort

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.9

Overall

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,011 reviews
Delta
7.9
Good
8,011 reviews

Comfort

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.9

Overall

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,066 reviews
Delta
7.9
Good
8,011 reviews

Comfort

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.9

Overall

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,047 reviews
Delta
7.9
Good
8,011 reviews

Comfort

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.9

Overall

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Sioux Falls to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Sioux Falls to Knoxville?

    Departing from Sioux Falls to Knoxville will take you 7h 46m. The distance from Sioux Falls to Knoxville is about 863 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Sioux Falls to Knoxville round-trip?

    Cheapflights users have booked flights from Sioux Falls to Knoxville round-trip from $248. Other airlines that can offer you cheap pricing are Delta, from $248, and United Airlines, from $268. American Airlines is priced at 33% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Sioux Falls to Knoxville that include hotel bookings?

    Yes. In addition to deals on Sioux Falls to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Sioux Falls to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Sioux Falls to Knoxville.

  • Can I find deals for business class flights from Sioux Falls to Knoxville?

    Yes. Cheapflights offers flight deals from Sioux Falls to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Sioux Falls to Knoxville?

    Currently, July is the cheapest month in which you can book a flight from Sioux Falls to Knoxville (average of $248). Flying from Sioux Falls to Knoxville in January is currently the most expensive (average of $387). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

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Alternative routes for Sioux Falls to Knoxville

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Top 3 airlines flying from Sioux Falls to Knoxville

Discover the top 3 airlines that operate flights from Sioux Falls to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$360FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$323FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$268Average$416FlexibilityNo cancel feeOn-time69%

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