$284+ Cheap flights from Knoxville to Sioux Falls (TYS - FSD)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/30. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — FSD
Nov 24 — Dec 11
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Knoxville to Sioux Falls with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Sioux Falls
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to Sioux FallsExplore the most affordable flight options available from Knoxville to Sioux Falls. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
Explore the most affordable flight options available from Knoxville to Sioux Falls. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/95:30 am -
1 stop7h 54m
Mon 12/143:19 pm -
1 stop7h 07m
Deal found 10/24![American Airlines logo]()
$337
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/52:55 pm -
1 stop6h 59m
Mon 11/96:00 am -
1 stop7h 05m
Deal found 10/21![American Airlines logo]()
$369
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2411:24 am -
2 stops30h 40m
Mon 11/306:30 pm -
1 stop14h 42m
Deal found 10/21![Multiple Airlines logo]()
$380
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/105:30 am -
1 stop7h 54m
Sat 1/164:15 pm -
1 stop7h 13m
Deal found 10/19![American Airlines logo]()
$387
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/243:38 pm -
1 stop26h 26m
Mon 11/306:30 pm -
1 stop14h 42m
Deal found 10/21![Allegiant Air logo]()
$410
This Delta deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/911:49 am -
2 stops9h 19m
Mon 12/145:02 am -
2 stops9h 11m
Deal found 10/24![Delta logo]()
$419
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/59:28 pm -
1 stop21h 55m
Mon 11/99:28 am -
2 stops26h 07m
Deal found 10/21![Allegiant Air logo]()
$422
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/59:00 am -
1 stop8h 25m
Mon 11/95:55 am -
2 stops10h 04m
Deal found 10/20![United Airlines logo]()
$484
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/174:00 pm -
1 stop4h 56m
Tue 11/248:31 am -
1 stop6h 49m
Deal found 10/19![Delta logo]()
$488
Best flights from Knoxville to Sioux FallsDiscover carefully curated flight deals from Knoxville to Sioux Falls that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
Discover carefully curated flight deals from Knoxville to Sioux Falls that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/912:19 pm -
2 stops7h 45m
Mon 12/141:04 pm -
1 stop7h 35m
Deal found 10/24![American Airlines logo]()
$342
This Delta deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/911:49 am -
2 stops9h 19m
Mon 12/145:02 am -
2 stops9h 11m
Deal found 10/24![Delta logo]()
$419
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/59:00 am -
1 stop8h 25m
Mon 11/95:55 am -
2 stops10h 04m
Deal found 10/20![United Airlines logo]()
$484
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/175:10 pm -
2 stops6h 50m
Tue 11/248:31 am -
1 stop6h 49m
Deal found 10/19![Delta logo]()
$493
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1710:33 am -
2 stops10h 31m
Tue 11/246:00 am -
2 stops16h 59m
Deal found 10/19![United Airlines logo]()
$622
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:30 am -
2 stops8h 23m
Wed 11/1112:14 pm -
1 stop5h 32m
Deal found 10/23![American Airlines logo]()
$628
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/109:45 am -
2 stops13h 27m
Sat 1/167:30 am -
3 stops30h 17m
Deal found 10/19![United Airlines logo]()
$735
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/126:52 am -
1 stop6h 32m
Sat 12/2612:04 pm -
1 stop8h 33m
Deal found 10/23![American Airlines logo]()
$753
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/242:40 pm -
1 stop6h 16m
Sun 11/295:25 am -
1 stop5h 03m
Deal found 10/19![Delta logo]()
$786
Last-minute flights from Knoxville to Sioux FallsDiscover last-minute flight deals from Knoxville to Sioux Falls. Data last updated October 25, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Sioux Falls. Data last updated October 25, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/52:55 pm -
1 stop6h 59m
Mon 11/96:00 am -
1 stop7h 05m
Deal found 10/21![American Airlines logo]()
$369
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/59:28 pm -
1 stop21h 55m
Mon 11/99:28 am -
2 stops26h 07m
Deal found 10/21![Allegiant Air logo]()
$422
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/59:00 am -
1 stop8h 25m
Mon 11/95:55 am -
2 stops10h 04m
Deal found 10/20![United Airlines logo]()
$484
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/174:00 pm -
1 stop4h 56m
Tue 11/248:31 am -
1 stop6h 49m
Deal found 10/19![Delta logo]()
$488
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/208:50 pm -
1 stop4h 54m
Mon 11/306:00 am -
1 stop7h 04m
Deal found 10/19![American Airlines logo]()
$503
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2411:24 am -
2 stops30h 40m
Mon 11/306:30 pm -
1 stop14h 42m
Deal found 10/21![Multiple Airlines logo]()
$380
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/243:38 pm -
1 stop26h 26m
Mon 11/306:30 pm -
1 stop14h 42m
Deal found 10/21![Allegiant Air logo]()
$410
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2411:24 am -
2 stops30h 40m
Sun 11/297:11 pm -
1 stop15h 12m
Deal found 10/21![Multiple Airlines logo]()
$504
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/243:38 pm -
1 stop26h 26m
Sun 11/297:11 pm -
1 stop15h 12m
Deal found 10/21![Allegiant Air logo]()
$534
One-way flights from Knoxville to Sioux FallsSearch for one-way flight options from Knoxville to Sioux Falls. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
Search for one-way flight options from Knoxville to Sioux Falls. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/308:50 pm -
1 stop4h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![American Airlines logo]()
$284
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/302:50 pm -
2 stops48h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Multiple Airlines logo]()
$334
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/305:40 am -
2 stops7h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Delta logo]()
$435
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/307:35 pm -
2 stops27h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![United Airlines logo]()
$584
Find flight deals from Knoxville to Sioux Falls
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Sioux Falls (FSD). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 25, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $337 (American Airlines) |
One-way from | $284 (American Airlines) |
Popular in | June |
Cheapest in | February |
Average price | $660 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Sioux Falls that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
Use the filters below to find and compare flights from Knoxville to Sioux Falls that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
KnoxvilleSioux Falls
TYS Knoxville McGhee Tyson - FSD Sioux Falls Joe Foss Field
TYSFSD
Knoxville McGhee Tyson
Mon 11/30
8:50 pm-12:44 am
1 stop4h 54m
Sioux Falls Joe Foss Field
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$284
KnoxvilleSioux Falls
TYS Knoxville McGhee Tyson - FSD Sioux Falls Joe Foss Field
TYSFSD
Knoxville McGhee Tyson
Wed 12/9
12:19 pm-7:04 pm
2 stops7h 45m
Sioux Falls Joe Foss Field
Mon 12/14
1:04 pm-9:39 pm
1 stop7h 35m
$342
KnoxvilleSioux Falls
TYS Knoxville McGhee Tyson - FSD Sioux Falls Joe Foss Field
TYSFSD
Knoxville McGhee Tyson
Mon 11/30
6:41 pm-2:47 pm
3 stops45h 06m
Sioux Falls Joe Foss Field
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$383
KnoxvilleSioux Falls
TYS Knoxville McGhee Tyson - FSD Sioux Falls Joe Foss Field
TYSFSD
Knoxville McGhee Tyson
Wed 12/9
11:49 am-8:08 pm
2 stops9h 19m
Sioux Falls Joe Foss Field
Mon 12/14
5:02 am-3:13 pm
2 stops9h 11m
$419
KnoxvilleSioux Falls
TYS Knoxville McGhee Tyson - FSD Sioux Falls Joe Foss Field
TYSFSD
Knoxville McGhee Tyson
Mon 11/30
5:40 am-12:17 pm
2 stops7h 37m
Sioux Falls Joe Foss Field
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$435
KnoxvilleSioux Falls
TYS Knoxville McGhee Tyson - FSD Sioux Falls Joe Foss Field
TYSFSD
Knoxville McGhee Tyson
Thu 11/5
9:00 am-4:25 pm
1 stop8h 25m
Sioux Falls Joe Foss Field
Mon 11/9
5:55 am-4:59 pm
2 stops10h 04m
$484
KnoxvilleSioux Falls
TYS Knoxville McGhee Tyson - FSD Sioux Falls Joe Foss Field
TYSFSD
Knoxville McGhee Tyson
Tue 11/17
5:10 pm-11:00 pm
2 stops6h 50m
Sioux Falls Joe Foss Field
Tue 11/24
8:31 am-4:20 pm
1 stop6h 49m
$493
KnoxvilleSioux Falls
TYS Knoxville McGhee Tyson - FSD Sioux Falls Joe Foss Field
TYSFSD
Knoxville McGhee Tyson
Mon 11/30
7:35 pm-10:12 pm
2 stops27h 37m
Sioux Falls Joe Foss Field
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$584
KnoxvilleSioux Falls
TYS Knoxville McGhee Tyson - FSD Sioux Falls Joe Foss Field
TYSFSD
Knoxville McGhee Tyson
Tue 11/17
10:33 am-8:04 pm
2 stops10h 31m
Sioux Falls Joe Foss Field
Tue 11/24
6:00 am-11:59 pm
2 stops16h 59m
$622
KnoxvilleSioux Falls
TYS Knoxville McGhee Tyson - FSD Sioux Falls Joe Foss Field
TYSFSD
Knoxville McGhee Tyson
Sat 11/7
7:30 am-2:53 pm
2 stops8h 23m
Sioux Falls Joe Foss Field
Wed 11/11
12:14 pm-6:46 pm
1 stop5h 32m
$628
Showing 1-10 of 13 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Sioux Falls
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Sioux Falls in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Sioux Falls flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Sioux Falls flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Sioux Falls flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Sioux Falls flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Sioux Falls flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Sioux Falls
Have a flexible travel schedule? Discover the best time to fly to Sioux Falls from Knoxville with our price prediction graph.
TYS-FSD
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Sioux Falls
What is the cheapest month to book a flight from Knoxville to Sioux Falls?
Currently, February is the cheapest month in which you can book a flight from Knoxville to Sioux Falls (average of $269). Flying from Knoxville to Sioux Falls in June is currently the most expensive (average of $850). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to Sioux Falls?
Airfare is below average for this route at the moment.
Knoxville to Sioux Falls flights typically cost between $350 and $554 in December.The cheapest round-trip price found within the last 5 days was $337 on American Airlines (Dec 9-Dec 14).
Reviews of airlines servicing Sioux Falls
Get insights into the airlines that provide service to Sioux Falls. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Sioux Falls. Reviews last updated October 25, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Sioux Falls by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Overall
7.8
Food
7.2
Comfort
7.8
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Boarding
8.1
Overall
7.8
Food
7.2
Comfort
7.8
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Boarding
8.1
Overall
7.8
Food
7.2
Comfort
7.8
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Sioux Falls. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Sioux Falls?
Book flights to Sioux Falls if you plan to visit one of these locationsYankton
Marshall
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Knoxville
Popular flights
Sioux Falls flight routes
Alternative routes for Knoxville to Sioux Falls
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Sioux Falls by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to Sioux Falls by cabin class
Find flights from Knoxville to Sioux Falls, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and Sioux Falls flights
Browse other Knoxville and Sioux Falls flight options. Last updated on October 25, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on October 25, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Sioux Falls
Explore flights to Sioux Falls departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 25, 2026.
Top 2 airlines flying from Knoxville to Sioux Falls
Discover the top 2 airlines that operate flights from Knoxville to Sioux Falls. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$288 | Average$434 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$339 | Average$448 | FlexibilityNo cancel fee | On-timeN/A |