HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Sioux Falls

$334+ Cheap flights from Knoxville to Sioux Falls (TYS - FSD)

TYS — FSD
Oct 10 — Oct 171
Sat 10/10
Sat 10/17
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Sioux Falls with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Sioux Falls

Cheapest flights from Knoxville to Sioux Falls

Thu 9/248:15 pm -
1 stop5h 14m
Sun 9/276:00 am -
1 stop5h 53m
Deal found 9/5$334
Wed 10/76:55 pm -
1 stop6h 46m
Wed 10/1412:53 pm -
2 stops9h 06m
Deal found 9/9$338
Wed 9/233:53 pm -
2 stops9h 36m
Sun 9/276:00 am -
1 stop5h 53m
Deal found 9/8$354
Thu 10/156:55 pm -
1 stop6h 46m
Mon 10/196:20 am -
1 stop6h 47m
Deal found 9/6$399
Fri 10/96:55 pm -
1 stop6h 46m
Fri 10/1612:53 pm -
2 stops10h 02m
Deal found 9/8$404
Fri 10/309:00 am -
1 stop8h 25m
Mon 11/21:20 pm -
1 stop8h 12m
Deal found 9/6$419

Find flight deals from Knoxville to Sioux Falls

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$334
(American Airlines)

Popular in

June

Cheapest in

February

Average price

$570
Provider with most accurate pricing for Knoxville McGhee Tyson-Sioux Falls Joe Foss Field flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Sioux Falls Joe Foss Field flights.
Search Deals
From Knoxville McGhee Tyson to Sioux Falls Joe Foss Field
Search Deals
Highest demand for flights based on searches. 22% potential increase in price ($135 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($35 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2026
Search Deals

Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Knoxville to Sioux Falls that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSioux Falls

TYS Knoxville McGhee Tyson - FSD Sioux Falls Joe Foss Field

TYSFSD

Knoxville McGhee Tyson

Thu 9/24

8:15 pm-12:29 am

1 stop5h 14m

Sioux Falls Joe Foss Field

Sun 9/27

6:00 am-12:53 pm

1 stop5h 53m

$334

KnoxvilleSioux Falls

TYS Knoxville McGhee Tyson - FSD Sioux Falls Joe Foss Field

TYSFSD

Knoxville McGhee Tyson

Wed 10/7

6:55 pm-12:41 am

1 stop6h 46m

Sioux Falls Joe Foss Field

Wed 10/14

12:53 pm-10:59 pm

2 stops9h 06m

$338
Quickest round-trip

KnoxvilleSioux Falls

TYS Knoxville McGhee Tyson - FSD Sioux Falls Joe Foss Field

TYSFSD

Knoxville McGhee Tyson

Mon 9/28

8:15 pm-12:29 am

1 stop5h 14m

Sioux Falls Joe Foss Field

Wed 12/31

12:00 am-1:00 am

Nonstop0h 00m

$370

KnoxvilleSioux Falls

TYS Knoxville McGhee Tyson - FSD Sioux Falls Joe Foss Field

TYSFSD

Knoxville McGhee Tyson

Fri 10/30

9:00 am-4:25 pm

1 stop8h 25m

Sioux Falls Joe Foss Field

Mon 11/2

1:20 pm-10:32 pm

1 stop8h 12m

$399

KnoxvilleSioux Falls

TYS Knoxville McGhee Tyson - FSD Sioux Falls Joe Foss Field

TYSFSD

Knoxville McGhee Tyson

Mon 9/28

7:25 pm-10:29 am

2 stops16h 04m

Sioux Falls Joe Foss Field

Wed 12/31

12:00 am-1:00 am

Nonstop0h 00m

$543

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/8

Sorted by cheapest first

Compare providers for flights from Knoxville to Sioux Falls

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Sioux Falls in September.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Sioux Falls flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Sioux Falls flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Sioux Falls flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Sioux Falls flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Sioux Falls flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Sioux Falls

Have a flexible travel schedule? Discover the best time to fly to Sioux Falls from Knoxville with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Sioux Falls

What is the cheapest month to book a flight from Knoxville to Sioux Falls?

Currently, February is the cheapest month in which you can book a flight from Knoxville to Sioux Falls (average of $269). Flying from Knoxville to Sioux Falls in June is currently the most expensive (average of $850). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Sioux Falls

Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Sioux Falls by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.8
Good
8,554 reviews

Comfort

7.8

Entertainment

7.8

Food

7.2

Crew

8.5

Boarding

8.1

Overall

7.8

Reviews

1 / 20
8.0
Excellent

Jorge,Aug 2026

TPA - ATL

Although I still enjoy flying Delta, the overall flying experience feels cheapened. But I guess that is true of most, if not all american carriers.
Delta
7.8
Good
8,554 reviews
Delta
7.8
Good
8,554 reviews

Comfort

7.8

Entertainment

7.8

Food

7.2

Crew

8.5

Boarding

8.1

Overall

7.8

Reviews

1 / 20
8.0
Excellent

Jorge,Aug 2026

TPA - ATL

Although I still enjoy flying Delta, the overall flying experience feels cheapened. But I guess that is true of most, if not all american carriers.
American Airlines
7.1
Good
12,045 reviews
Delta
7.8
Good
8,554 reviews

Comfort

7.8

Entertainment

7.8

Food

7.2

Crew

8.5

Boarding

8.1

Overall

7.8

Reviews

1 / 20
8.0
Excellent

Jorge,Aug 2026

TPA - ATL

Although I still enjoy flying Delta, the overall flying experience feels cheapened. But I guess that is true of most, if not all american carriers.

Related info for your journey

  • How long is the flight from Knoxville to Sioux Falls?

    Departing from Knoxville to Sioux Falls will take you 5h 14m. The distance from Knoxville to Sioux Falls is about 863 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Knoxville to Sioux Falls round-trip?

    Flying on American Airlines is currently your cheapest option to Sioux Falls, with prices starting at $288. Another option worth looking into is Delta, starting at $339 round trip. Users have found that American Airlines is 37% cheaper than the other options available to this destination.

  • Can I find deals for flights from Knoxville to Sioux Falls that include hotel bookings?

    Yes. In addition to deals on Knoxville to Sioux Falls flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Sioux Falls?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Sioux Falls.

  • Can I find deals for business class flights from Knoxville to Sioux Falls?

    Yes. Cheapflights offers flight deals from Knoxville to Sioux Falls by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Sioux Falls?

    Currently, February is the cheapest month in which you can book a flight from Knoxville to Sioux Falls (average of $269). Flying from Knoxville to Sioux Falls in June is currently the most expensive (average of $850). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Sioux Falls?

Book flights to Sioux Falls if you plan to visit one of these locations
Yankton
Marshall

Browse thousands of different options on Cheapflights for your next trip

Top 2 airlines flying from Knoxville to Sioux Falls

AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$288Average$470FlexibilityNo cancel feeOn-time71%
DeltaCheapest$339Average$448FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.