South Dakota

$284+ Cheap flights from Knoxville (TYS) to South Dakota

TYS — FSD
Dec 8 — Dec 151
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Cheap flight deals from Knoxville to South Dakota

Cheapest flights from Knoxville to South Dakota

Sat 12/52:55 pm -
1 stop8h 37m
Sat 12/121:09 pm -
1 stop8h 31m
Deal found 11/4$301
Sat 12/57:10 am -
2 stops10h 43m
Sat 12/124:36 pm -
1 stop4h 48m
Deal found 11/4$306
Sat 12/56:00 am -
2 stops9h 03m
Sat 12/127:00 am -
2 stops8h 00m
Deal found 11/4$311
Thu 12/34:43 pm -
1 stop7h 46m
Thu 12/107:00 am -
1 stop5h 40m
Deal found 11/5$359
Tue 11/174:00 pm -
1 stop4h 56m
Sat 11/215:00 pm -
1 stop5h 11m
Deal found 11/3$369
Thu 11/198:50 pm -
1 stop4h 58m
Mon 11/236:00 am -
2 stops9h 36m
Deal found 11/4$384
Fri 11/135:05 pm -
1 stop7h 39m
Wed 11/186:00 am -
1 stop6h 13m
Deal found 11/3$399
Thu 11/195:05 pm -
1 stop7h 25m
Mon 11/231:30 pm -
1 stop5h 24m
Deal found 11/3$399
Fri 11/133:43 pm -
2 stops9h 46m
Wed 11/183:27 pm -
1 stop7h 20m
Deal found 11/3$404
Tue 11/178:13 am -
2 stops7h 43m
Sat 11/211:13 pm -
2 stops9h 46m
Deal found 11/3$412
Fri 11/206:45 am -
1 stop5h 46m
Tue 11/2412:39 pm -
1 stop7h 53m
Deal found 11/5$419
Wed 11/42:55 pm -
1 stop8h 32m
Sun 11/86:11 am -
1 stop8h 31m
Deal found 11/3$449

Find flight deals from Knoxville to South Dakota

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$301
(American Airlines)

One-way from

$284
(American Airlines)

Popular in

June

Cheapest in

February

Average price

$385
Provider with most accurate pricing for Knoxville McGhee Tyson-Sioux Falls Joe Foss Field flight deals.
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Sioux Falls Joe Foss Field flights.
From Knoxville McGhee Tyson to South Dakota
One-way flight from Knoxville McGhee Tyson to South Dakota
Highest demand for flights based on searches. 18% potential increase in price ($112 potential increase over avg. RT price).
Cheapest flight prices on average. 7% potential price decrease ($34 potential savings vs. average RT price).
Average for round-trip flights in November 2026

Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Knoxville to South Dakota that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

KnoxvilleSioux Falls

TYS Knoxville McGhee Tyson - FSD Sioux Falls Joe Foss Field

TYSFSD

Knoxville McGhee Tyson

Mon 11/30

8:50 pm-12:44 am

1 stop4h 54m

Sioux Falls Joe Foss Field

Wed 12/31

12:00 am-1:00 am

Nonstop0h 00m

$289

KnoxvilleRapid City

TYS Knoxville McGhee Tyson - RAP Rapid City

TYSRAP

Knoxville McGhee Tyson

Sat 12/5

7:10 am-3:53 pm

2 stops10h 43m

Rapid City

Sat 12/12

4:36 pm-11:24 pm

1 stop4h 48m

$306

KnoxvilleRapid City

TYS Knoxville McGhee Tyson - RAP Rapid City

TYSRAP

Knoxville McGhee Tyson

Sat 12/5

6:00 am-1:03 pm

2 stops9h 03m

Rapid City

Sat 12/12

7:00 am-5:00 pm

2 stops8h 00m

$311

KnoxvilleSioux Falls

TYS Knoxville McGhee Tyson - FSD Sioux Falls Joe Foss Field

TYSFSD

Knoxville McGhee Tyson

Mon 11/30

6:41 pm-2:47 pm

3 stops45h 06m

Sioux Falls Joe Foss Field

Wed 12/31

12:00 am-1:00 am

Nonstop0h 00m

$332

KnoxvilleSioux Falls

TYS Knoxville McGhee Tyson - FSD Sioux Falls Joe Foss Field

TYSFSD

Knoxville McGhee Tyson

Tue 11/17

4:00 pm-7:56 pm

1 stop4h 56m

Sioux Falls Joe Foss Field

Sat 11/21

5:00 pm-11:11 pm

1 stop5h 11m

$369

KnoxvilleSioux Falls

TYS Knoxville McGhee Tyson - FSD Sioux Falls Joe Foss Field

TYSFSD

Knoxville McGhee Tyson

Thu 11/19

5:40 pm-9:37 pm

1 stop4h 57m

Sioux Falls Joe Foss Field

Mon 11/23

1:20 pm-10:32 pm

1 stop8h 12m

$369

KnoxvilleRapid City

TYS Knoxville McGhee Tyson - RAP Rapid City

TYSRAP

Knoxville McGhee Tyson

Tue 5/4

5:15 pm-10:39 pm

2 stops7h 24m

Rapid City

Tue 5/11

2:25 pm-11:46 pm

2 stops7h 21m

$376

KnoxvilleSioux Falls

TYS Knoxville McGhee Tyson - FSD Sioux Falls Joe Foss Field

TYSFSD

Knoxville McGhee Tyson

Thu 11/19

8:50 pm-12:48 am

1 stop4h 58m

Sioux Falls Joe Foss Field

Mon 11/23

6:00 am-4:36 pm

2 stops9h 36m

$384

KnoxvilleRapid City

TYS Knoxville McGhee Tyson - RAP Rapid City

TYSRAP

Knoxville McGhee Tyson

Wed 1/20

4:28 pm-8:30 pm

1 stop6h 02m

Rapid City

Sat 1/23

7:00 am-2:56 pm

1 stop5h 56m

$411

KnoxvilleRapid City

TYS Knoxville McGhee Tyson - RAP Rapid City

TYSRAP

Knoxville McGhee Tyson

Thu 11/19

7:00 am-3:19 pm

2 stops10h 19m

Rapid City

Mon 11/23

1:30 pm-8:54 pm

1 stop5h 24m

$414

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/6

Showing 1-10 of 18 resultsSorted by cheapest first
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Best time to book a flight from Knoxville to South Dakota

Have a flexible travel schedule? Discover the best time to fly to South Dakota from Knoxville with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from Knoxville to South Dakota

What is the cheapest month to book a flight from Knoxville to South Dakota?

Currently, January is the cheapest month in which you can book a flight from Knoxville to South Dakota (average of $340). Flying from Knoxville to South Dakota in June is currently the most expensive (average of $633). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South Dakota

See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Knoxville to South Dakota have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Food

7.2

Comfort

7.8

Entertainment

7.8

Boarding

8.1

Overall

7.8

Crew

8.5

Reviews

1 / 20
6.0
Good

Ellen,Oct 2026

GRR - ATL

The flight was delayed more then 30 minutes after I hurried and stressed to get to my connecting gate in Atlanta.

Food

7.2

Comfort

7.8

Entertainment

7.8

Boarding

8.1

Overall

7.8

Crew

8.5

Reviews

1 / 20
6.0
Good

Ellen,Oct 2026

GRR - ATL

The flight was delayed more then 30 minutes after I hurried and stressed to get to my connecting gate in Atlanta.

Food

7.2

Comfort

7.8

Entertainment

7.8

Boarding

8.1

Overall

7.8

Crew

8.5

Reviews

1 / 20
6.0
Good

Ellen,Oct 2026

GRR - ATL

The flight was delayed more then 30 minutes after I hurried and stressed to get to my connecting gate in Atlanta.

Food

7.2

Comfort

7.8

Entertainment

7.8

Boarding

8.1

Overall

7.8

Crew

8.5

Reviews

1 / 20
6.0
Good

Ellen,Oct 2026

GRR - ATL

The flight was delayed more then 30 minutes after I hurried and stressed to get to my connecting gate in Atlanta.

Related info for your journey

  • What airport do you fly from for flights from Knoxville to South Dakota?

    Knoxville McGhee Tyson (TYS), located 11.3 mi from the city center, is the airport you fly out of when you book flights from Knoxville to South Dakota.

  • How long is the flight from Knoxville to South Dakota?

    Delta, United Airlines, and American Airlines can get you from Knoxville to South Dakota in just under 4h 58m. Your travel time can differ by up to 5h 45m. The distance from Knoxville to South Dakota is about 863 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Knoxville to South Dakota that include hotel bookings?

    Yes. In addition to deals on Knoxville to South Dakota flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to South Dakota?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to South Dakota.

  • Can I find deals for business class flights from Knoxville to South Dakota?

    Yes. Cheapflights offers flight deals from Knoxville to South Dakota by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to South Dakota?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to South Dakota (average of $340). Flying from Knoxville to South Dakota in June is currently the most expensive (average of $633). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Alternative routes for Knoxville to South Dakota

Top 3 airlines flying from Knoxville to South Dakota

AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$288Average$480FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$308Average$535FlexibilityNo cancel feeOn-time69%
DeltaCheapest$339Average$448FlexibilityNo cancel feeOn-timeN/A

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