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$147+ Cheap flights from Harrisburg to Knoxville (MDT - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/13. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — TYS
Jul 8 — Jul 151
Tue 7/8
Tue 7/15
1 adult, Economy
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Cheap flight deals from Harrisburg to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 3, 2025.

Round-trip from

$202
(Mytrip)

One-way from

$147
(Mytrip)

Popular in

February

Cheapest in

May

Average price

$313
From Harrisburg to Knoxville McGhee Tyson
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One-way flight from Harrisburg to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 28% potential increase in price ($164 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($29 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Harrisburg to Knoxville

Cheapest flights from Harrisburg to Knoxville
Explore the most affordable flight options available from Harrisburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.

This Mytrip deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/19:10 amMDT - TYS
1 stop12h 05mAllegiant Air
Sat 8/99:00 amTYS - MDT
1 stop6h 46mAllegiant Air
Deal found 7/2$202
This American Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/812:34 pmMDT - TYS
1 stop5h 13mAmerican Airlines
Wed 8/137:31 amTYS - MDT
1 stop4h 07mAmerican Airlines
Deal found 7/3$229
This Delta deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/86:25 pmMDT - TYS
1 stop5h 34mDelta
Wed 8/135:45 amTYS - MDT
2 stops5h 57mDelta
Deal found 7/1$234
This Mytrip deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/18:51 pmMDT - TYS
2 stops23h 05mMultiple Airlines
Sat 8/99:00 amTYS - MDT
1 stop6h 46mMultiple Airlines
Deal found 7/2$247
This United Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/48:30 amMDT - TYS
1 stop4h 53mUnited Airlines
Fri 7/115:45 amTYS - MDT
1 stop4h 00mUnited Airlines
Deal found 7/3$279

Cheapflights Fare Finder

Customize your flight search to find flights from Harrisburg to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 3, 2025.
Use the filters below to find and compare flights from Harrisburg to Knoxville that are best for you.

Fly from

Harrisburg

Fly to

Knoxville

Route

Depart

Return

Price

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 8/1

9:10 am-9:15 pm

1 stop12h 05m

Knoxville McGhee Tyson

Sat 8/9

9:00 am-3:46 pm

1 stop6h 46m

$202

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 8/8

12:34 pm-5:47 pm

1 stop5h 13m

Knoxville McGhee Tyson

Wed 8/13

7:31 am-11:38 am

1 stop4h 07m

$229

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 8/8

6:25 pm-11:59 pm

1 stop5h 34m

Knoxville McGhee Tyson

Wed 8/13

5:45 am-11:42 am

2 stops5h 57m

$234

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 8/1

8:51 pm-7:56 pm

2 stops23h 05m

Knoxville McGhee Tyson

Sat 8/9

9:00 am-3:46 pm

1 stop6h 46m

$247

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Tue 8/19

10:30 am-2:40 pm

1 stop4h 10m

Knoxville McGhee Tyson

Sun 8/24

5:45 am-9:33 am

1 stop3h 48m

$367

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sun 7/13

7:00 pm-8:02 am

1 stop13h 02m

$147

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Thu 9/4

6:00 am-10:42 am

1 stop4h 42m

$155

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Thu 8/7

7:59 pm-11:59 pm

1 stop4h 00m

$185

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/3

Best time to book a flight from Harrisburg to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to Knoxville

What is the cheapest month to book a flight from Harrisburg to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Harrisburg to Knoxville (average of $296). Flying from Harrisburg to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MDT to TYS?

Find hourly flight availability from Harrisburg to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 3, 2025.

A simple way to save on the total cost of your ticket is to fly from Harrisburg to Knoxville in the evening. If you’re flexible enough to do this you can expect to save up to 28% on your trip compared to booking a flight at noon.

How much does it cost to fly round-trip from Harrisburg to Knoxville?

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated July 3, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Harrisburg to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,970 reviews

Entertainment

7.9

Overall

8.0

Comfort

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,970 reviews
Delta
8.0
Very good
7,970 reviews

Entertainment

7.9

Overall

8.0

Comfort

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,845 reviews
Delta
8.0
Very good
7,970 reviews

Entertainment

7.9

Overall

8.0

Comfort

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,970 reviews

Entertainment

7.9

Overall

8.0

Comfort

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Allegiant Air
7.2
Good
709 reviews
Delta
8.0
Very good
7,970 reviews

Entertainment

7.9

Overall

8.0

Comfort

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Harrisburg to Knoxville round-trip?

    According to our current data, Allegiant Air ($202), American Airlines ($229), and Delta ($234) offers the cheapest pricing from Harrisburg to Knoxville. Allegiant Air is 51% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the cheapest airlines to fly from Harrisburg to Knoxville one-way?

    $147 is the cheapest one-way deal found within the past few days, from Allegiant Air. You may also be able to find cheap deals on Delta and United Airlines, with prices starting from $155 and $185, respectively.

  • Can I find deals for flights from Harrisburg to Knoxville that include hotel bookings?

    Yes. In addition to deals on Harrisburg to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to Knoxville.

  • Can I find deals for business class flights from Harrisburg to Knoxville?

    Yes. Cheapflights offers flight deals from Harrisburg to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Harrisburg to Knoxville (average of $296). Flying from Harrisburg to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Harrisburg?

Book flights to Harrisburg if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Alternative routes for Harrisburg to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Harrisburg to Knoxville

Discover the top 2 airlines that operate flights from Harrisburg to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$198Average$393FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$408FlexibilityNo cancel feeOn-time71%

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