$126+ Cheap flights from Buffalo to Knoxville (BUF - TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/6. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — TYS
Aug 14 — Aug 211
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Buffalo to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Buffalo to Knoxville
Cheapest
Best
Last-minute
One-way
Cheapest flights from Buffalo to KnoxvilleExplore the most affordable flight options available from Buffalo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 15, 2026.
Explore the most affordable flight options available from Buffalo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 15, 2026.
This Delta deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/123:54 pm
BUF
- TYS
1 stop5h 40m
Delta
Mon 8/177:41 pm
TYS
- BUF
1 stop4h 18m
Delta
Deal found 7/10![Delta logo]()
$233
This Southwest deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/223:30 pm
BUF
- TYS
1 stop3h 50m
Southwest
Thu 8/278:25 am
TYS
- BUF
1 stop10h 00m
Southwest
Deal found 7/10![Southwest logo]()
$240
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/139:33 pm
BUF
- TYS
1 stop25h 11m
Multiple Airlines
Thu 8/2012:55 pm
TYS
- BUF
2 stops21h 34m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$243
This Delta deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:00 am
BUF
- TYS
1 stop5h 01m
Delta
Wed 11/117:20 pm
TYS
- BUF
1 stop4h 35m
Delta
Deal found 7/10![Delta logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/122:48 pm
BUF
- TYS
2 stops28h 51m
Multiple Airlines
Mon 8/176:29 pm
TYS
- BUF
1 stop14h 54m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/297:57 pm
BUF
- TYS
1 stop26h 27m
Multiple Airlines
Fri 8/712:50 pm
TYS
- BUF
2 stops22h 43m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$262
This American Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/27:12 pm
BUF
- TYS
1 stop4h 39m
American Airlines
Wed 11/118:04 pm
TYS
- BUF
1 stop4h 04m
American Airlines
Deal found 7/10![American Airlines logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/108:54 pm
BUF
- TYS
1 stop15h 47m
Multiple Airlines
Sun 9/135:44 pm
TYS
- BUF
2 stops18h 37m
Multiple Airlines
Deal found 7/11![Multiple Airlines logo]()
$275
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:00 am
BUF
- TYS
1 stop5h 45m
American Airlines
Thu 8/206:32 pm
TYS
- BUF
1 stop5h 24m
American Airlines
Deal found 7/13![American Airlines logo]()
$279
Best flights from Buffalo to KnoxvilleDiscover carefully curated flight deals from Buffalo to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 15, 2026.
Discover carefully curated flight deals from Buffalo to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 15, 2026.
This Delta deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/123:54 pm
BUF
- TYS
1 stop5h 40m
Delta
Mon 8/177:41 pm
TYS
- BUF
1 stop4h 18m
Delta
Deal found 7/10![Delta logo]()
$233
This Southwest deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1012:45 pm
BUF
- TYS
1 stop7h 05m
Southwest
Sat 11/148:15 am
TYS
- BUF
1 stop5h 15m
Southwest
Deal found 7/14![Southwest logo]()
$284
This United Airlines deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/227:59 pm
BUF
- TYS
1 stop4h 00m
United Airlines
Tue 8/257:20 pm
TYS
- BUF
1 stop4h 24m
United Airlines
Deal found 7/11![United Airlines logo]()
$359
This Southwest deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/212:40 pm
BUF
- TYS
2 stops7h 50m
Southwest
Wed 11/117:55 am
TYS
- BUF
1 stop4h 15m
Southwest
Deal found 7/10![Southwest logo]()
$311
This Delta deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/207:19 pm
BUF
- TYS
1 stop4h 33m
Delta
Mon 8/247:41 pm
TYS
- BUF
1 stop4h 18m
Delta
Deal found 7/11![Delta logo]()
$318
This Delta deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/34:59 pm
BUF
- TYS
1 stop4h 46m
Delta
Sun 12/67:20 pm
TYS
- BUF
1 stop4h 35m
Delta
Deal found 7/14![Delta logo]()
$318
This Southwest deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/249:15 am
BUF
- TYS
2 stops7h 30m
Southwest
Mon 10/268:20 am
TYS
- BUF
1 stop3h 40m
Southwest
Deal found 7/11![Southwest logo]()
$323
This Delta deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:59 pm
BUF
- TYS
1 stop4h 56m
Delta
Sun 9/207:33 am
TYS
- BUF
1 stop3h 49m
Delta
Deal found 7/12![Delta logo]()
$357
Last-minute flights from Buffalo to KnoxvilleDiscover last-minute flight deals from Buffalo to Knoxville. Data last updated July 15, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to Knoxville. Data last updated July 15, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/297:57 pm
BUF
- TYS
1 stop26h 27m
Multiple Airlines
Fri 8/712:50 pm
TYS
- BUF
2 stops22h 43m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$262
This United Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/87:52 pm
BUF
- TYS
1 stop4h 02m
United Airlines
Thu 8/137:20 pm
TYS
- BUF
1 stop4h 24m
United Airlines
Deal found 7/10![United Airlines logo]()
$286
This Delta deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/123:54 pm
BUF
- TYS
1 stop5h 40m
Delta
Mon 8/177:41 pm
TYS
- BUF
1 stop4h 18m
Delta
Deal found 7/10![Delta logo]()
$233
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/122:48 pm
BUF
- TYS
2 stops28h 51m
Multiple Airlines
Mon 8/176:29 pm
TYS
- BUF
1 stop14h 54m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/139:33 pm
BUF
- TYS
1 stop25h 11m
Multiple Airlines
Thu 8/2012:55 pm
TYS
- BUF
2 stops21h 34m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$243
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:00 am
BUF
- TYS
1 stop5h 45m
American Airlines
Thu 8/206:32 pm
TYS
- BUF
1 stop5h 24m
American Airlines
Deal found 7/13![American Airlines logo]()
$279
This American Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:59 pm
BUF
- TYS
1 stop3h 59m
American Airlines
Sun 8/236:21 pm
TYS
- BUF
1 stop5h 15m
American Airlines
Deal found 7/10![American Airlines logo]()
$295
This Southwest deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/223:30 pm
BUF
- TYS
1 stop3h 50m
Southwest
Thu 8/278:25 am
TYS
- BUF
1 stop10h 00m
Southwest
Deal found 7/10![Southwest logo]()
$240
One-way flights from Buffalo to KnoxvilleSearch for one-way flight options from Buffalo to Knoxville. Find affordable one-way fares based on user searches. Data last updated July 15, 2026.
Search for one-way flight options from Buffalo to Knoxville. Find affordable one-way fares based on user searches. Data last updated July 15, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/611:29 am
BUF
- TYS
2 stops35h 15m
Multiple Airlines
Deal found 7/10![Multiple Airlines logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/122:48 pm
BUF
- TYS
2 stops28h 51m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1311:29 am
BUF
- TYS
2 stops35h 15m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$130
This United Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1110:30 am
BUF
- TYS
1 stop6h 28m
United Airlines
Deal found 7/13![United Airlines logo]()
$140
This United Airlines deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/510:30 am
BUF
- TYS
2 stops10h 23m
United Airlines
Deal found 7/11![United Airlines logo]()
$145
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1111:29 am
BUF
- TYS
2 stops24h 37m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$151
This United Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:15 am
BUF
- TYS
1 stop4h 27m
United Airlines
Deal found 7/10![United Airlines logo]()
$180
This Kiwi.com deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/29:29 pm
BUF
- TYS
1 stop26h 04m
Multiple Airlines
Deal found 7/12![Multiple Airlines logo]()
$185
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/1611:29 am
BUF
- TYS
2 stops35h 15m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$207
Find flight deals from Buffalo to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 15, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $233 (Delta) |
One-way from | $126 (Kiwi.com) |
Popular in | February |
Cheapest in | August |
Average price | $486 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 15, 2026.
Use the filters below to find and compare flights from Buffalo to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Wed 8/12
3:54 pm-9:34 pm
1 stop5h 40m
Knoxville McGhee Tyson
Mon 8/17
7:41 pm-11:59 pm
1 stop4h 18m
$233
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Tue 11/10
12:45 pm-7:50 pm
1 stop7h 05m
Knoxville McGhee Tyson
Sat 11/14
8:15 am-1:30 pm
1 stop5h 15m
$284
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Mon 11/2
12:40 pm-8:30 pm
2 stops7h 50m
Knoxville McGhee Tyson
Wed 11/11
7:55 am-12:10 pm
1 stop4h 15m
$311
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Thu 8/20
7:19 pm-11:52 pm
1 stop4h 33m
Knoxville McGhee Tyson
Mon 8/24
7:41 pm-11:59 pm
1 stop4h 18m
$318
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Thu 12/3
4:59 pm-9:45 pm
1 stop4h 46m
Knoxville McGhee Tyson
Sun 12/6
7:20 pm-11:55 pm
1 stop4h 35m
$318
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Sat 10/24
9:15 am-4:45 pm
2 stops7h 30m
Knoxville McGhee Tyson
Mon 10/26
8:20 am-12:00 pm
1 stop3h 40m
$323
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Fri 9/18
6:59 pm-11:55 pm
1 stop4h 56m
Knoxville McGhee Tyson
Sun 9/20
7:33 am-11:22 am
1 stop3h 49m
$357
Quickest round-trip
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Sat 8/22
7:59 pm-11:59 pm
1 stop4h 00m
Knoxville McGhee Tyson
Tue 8/25
7:20 pm-11:44 pm
1 stop4h 24m
$359
Cheapest one-way
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Thu 8/6
11:29 am-10:44 pm
2 stops35h 15m
$126
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Mon 8/17
7:19 pm-11:52 pm
1 stop4h 33m
$140
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from Buffalo to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Knoxville in July.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Buffalo-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Buffalo-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Buffalo-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Buffalo-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Buffalo to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Buffalo with our price prediction graph.
BUF-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to Knoxville
What is the cheapest month to book a flight from Buffalo to Knoxville?
Currently, August is the cheapest month in which you can book a flight from Buffalo to Knoxville (average of $343). Flying from Buffalo to Knoxville in February is currently the most expensive (average of $646). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Buffalo to Knoxville?
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated July 15, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Buffalo to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Crew
8.5
Food
7.2
Boarding
8.1
Overall
7.8
Entertainment
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Comfort
7.8
Crew
8.5
Food
7.2
Boarding
8.1
Overall
7.8
Entertainment
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Comfort
7.8
Crew
8.5
Food
7.2
Boarding
8.1
Overall
7.8
Entertainment
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Comfort
7.8
Crew
8.5
Food
7.2
Boarding
8.1
Overall
7.8
Entertainment
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Related info for your journey
Find useful and relevant information for your journey from Buffalo to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Knoxville flight routes
Other flight options
Other flights from Buffalo
Popular flights
Alternative routes for Buffalo to Knoxville
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Knoxville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Buffalo to Knoxville by cabin class
Find flights from Buffalo to Knoxville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 15, 2026.
Buffalo and Knoxville flights
Browse other Buffalo and Knoxville flight options. Last updated on July 15, 2026.
Other flights from Buffalo
Browse through other flights departing from Buffalo. Flights are based on user searches made on Cheapflights and were last updated on July 15, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Buffalo to Knoxville
Discover the top 3 airlines that operate flights from Buffalo to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 15, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$250 | Average$396 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$259 | Average$376 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$346 | Average$411 | FlexibilityNo cancel fee | On-time69% |