$126+ Cheap flights from Buffalo to Knoxville (BUF - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/24. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — TYS
Nov 21 — Nov 281
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Buffalo to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Buffalo to Knoxville
Cheapest
Best
Last-minute
One-way
Cheapest flights from Buffalo to KnoxvilleExplore the most affordable flight options available from Buffalo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 22, 2026.
Explore the most affordable flight options available from Buffalo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 22, 2026.
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:24 am -
1 stop4h 03m
Tue 12/227:00 am -
1 stop4h 10m
Deal found 10/20![Delta logo]()
$251
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:30 pm -
1 stop4h 15m
Tue 11/177:55 am -
1 stop8h 35m
Deal found 10/19![Southwest logo]()
$262
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:37 pm -
1 stop4h 21m
Mon 11/163:55 pm -
1 stop6h 49m
Deal found 10/19![American Airlines logo]()
$285
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:00 am -
2 stops8h 48m
Mon 11/167:35 pm -
1 stop4h 11m
Deal found 10/19![United Airlines logo]()
$290
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/910:00 am -
1 stop6h 45m
Sun 12/137:26 pm -
1 stop4h 38m
Deal found 10/21![Delta logo]()
$302
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/911:23 am -
2 stops9h 24m
Tue 12/225:30 am -
1 stop4h 15m
Deal found 10/20![United Airlines logo]()
$346
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1510:00 am -
1 stop4h 53m
Wed 12/166:20 am -
1 stop4h 22m
Deal found 10/20![United Airlines logo]()
$351
Best flights from Buffalo to KnoxvilleDiscover carefully curated flight deals from Buffalo to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 22, 2026.
Discover carefully curated flight deals from Buffalo to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 22, 2026.
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:24 am -
1 stop4h 03m
Tue 12/227:00 am -
1 stop4h 10m
Deal found 10/20![Delta logo]()
$251
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/111:13 am -
2 stops8h 31m
Thu 2/49:45 am -
2 stops6h 56m
Deal found 10/21![United Airlines logo]()
$261
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/103:55 pm -
1 stop4h 55m
Tue 12/228:00 am -
2 stops8h 55m
Deal found 10/20![Southwest logo]()
$385
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/911:23 am -
2 stops9h 24m
Tue 12/225:30 am -
1 stop4h 15m
Deal found 10/20![United Airlines logo]()
$346
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/246:45 pm -
1 stop5h 01m
Sun 3/285:30 am -
1 stop5h 45m
Deal found 10/20![Delta logo]()
$387
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1510:30 am -
1 stop6h 30m
Wed 12/161:55 pm -
2 stops9h 39m
Deal found 10/21![United Airlines logo]()
$356
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/910:00 am -
1 stop6h 45m
Sun 12/137:26 pm -
1 stop4h 38m
Deal found 10/19![Delta logo]()
$387
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/206:00 am -
2 stops10h 48m
Sat 2/2710:16 am -
1 stop3h 30m
Deal found 10/18![United Airlines logo]()
$392
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/246:00 am -
1 stop4h 00m
Sun 3/287:35 pm -
1 stop4h 07m
Deal found 10/20![United Airlines logo]()
$394
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:00 am -
2 stops11h 00m
Sun 12/136:20 am -
1 stop4h 22m
Deal found 10/22![United Airlines logo]()
$407
Last-minute flights from Buffalo to KnoxvilleDiscover last-minute flight deals from Buffalo to Knoxville. Data last updated October 22, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to Knoxville. Data last updated October 22, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/23:05 pm -
1 stop6h 35m
Fri 11/612:50 pm -
1 stop5h 45m
Deal found 10/18![Southwest logo]()
$487
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:00 am -
1 stop5h 30m
Sun 11/85:45 am -
1 stop4h 09m
Deal found 10/19![United Airlines logo]()
$558
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:52 pm -
1 stop4h 07m
Tue 11/109:45 am -
1 stop4h 25m
Deal found 10/22![United Airlines logo]()
$405
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:30 pm -
1 stop4h 15m
Tue 11/177:55 am -
1 stop8h 35m
Deal found 10/19![Southwest logo]()
$262
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:37 pm -
1 stop4h 21m
Mon 11/163:55 pm -
1 stop6h 49m
Deal found 10/19![American Airlines logo]()
$285
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:00 am -
2 stops8h 48m
Mon 11/167:35 pm -
1 stop4h 11m
Deal found 10/19![United Airlines logo]()
$290
One-way flights from Buffalo to KnoxvilleSearch for one-way flight options from Buffalo to Knoxville. Find affordable one-way fares based on user searches. Data last updated October 22, 2026.
Search for one-way flight options from Buffalo to Knoxville. Find affordable one-way fares based on user searches. Data last updated October 22, 2026.
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:00 am -
1 stop3h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Delta logo]()
$126
This Delta deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1710:00 am -
1 stop6h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/18![Delta logo]()
$194
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1710:35 am -
2 stops10h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/18![United Airlines logo]()
$199
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/299:20 pm -
1 stop25h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Multiple Airlines logo]()
$227
This Kiwi.com deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/282:00 pm -
2 stops32h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![Multiple Airlines logo]()
$248
This Trip.com deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:47 pm -
2 stops17h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![Multiple Airlines logo]()
$256
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/21:48 pm -
3 stops44h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Multiple Airlines logo]()
$284
This Delta deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:00 am -
1 stop4h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![Delta logo]()
$315
Find flight deals from Buffalo to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 22, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $251 (Delta) |
One-way from | $126 (Delta) |
Popular in | February |
Cheapest in | June |
Average price | $387 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 22, 2026.
Use the filters below to find and compare flights from Buffalo to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
BuffaloKnoxville
BUF Buffalo - TYS Knoxville McGhee Tyson
BUFTYS
Buffalo
Tue 11/24
6:00 am-9:55 am
1 stop3h 55m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$126
BuffaloKnoxville
BUF Buffalo - TYS Knoxville McGhee Tyson
BUFTYS
Buffalo
Wed 12/30
12:19 pm-5:31 pm
1 stop5h 12m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$194
BuffaloKnoxville
BUF Buffalo - TYS Knoxville McGhee Tyson
BUFTYS
Buffalo
Tue 11/17
10:00 am-4:45 pm
1 stop6h 45m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$194
BuffaloKnoxville
BUF Buffalo - TYS Knoxville McGhee Tyson
BUFTYS
Buffalo
Tue 11/24
6:00 am-2:48 pm
2 stops8h 48m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$199
BuffaloKnoxville
BUF Buffalo - TYS Knoxville McGhee Tyson
BUFTYS
Buffalo
Tue 11/17
10:35 am-8:54 pm
2 stops10h 19m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$199
BuffaloKnoxville
BUF Buffalo - TYS Knoxville McGhee Tyson
BUFTYS
Buffalo
Sun 11/29
9:20 pm-10:58 pm
1 stop25h 38m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$227
BuffaloKnoxville
BUF Buffalo - TYS Knoxville McGhee Tyson
BUFTYS
Buffalo
Wed 10/28
2:00 pm-10:24 pm
2 stops32h 24m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$248
BuffaloKnoxville
BUF Buffalo - TYS Knoxville McGhee Tyson
BUFTYS
Buffalo
Wed 12/9
6:24 am-10:27 am
1 stop4h 03m
Knoxville McGhee Tyson
Tue 12/22
7:00 am-11:10 am
1 stop4h 10m
$251
BuffaloKnoxville
BUF Buffalo - TYS Knoxville McGhee Tyson
BUFTYS
Buffalo
Mon 2/1
11:13 am-7:44 pm
2 stops8h 31m
Knoxville McGhee Tyson
Thu 2/4
9:45 am-4:41 pm
2 stops6h 56m
$261
BuffaloKnoxville
BUF Buffalo - TYS Knoxville McGhee Tyson
BUFTYS
Buffalo
Mon 11/2
1:48 pm-10:05 am
3 stops44h 17m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$284
Showing 1-10 of 22 resultsSorted by cheapest first
Compare providers for flights from Buffalo to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Knoxville in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Buffalo-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Buffalo-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Buffalo-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Buffalo-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Buffalo to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Buffalo with our price prediction graph.
BUF-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to Knoxville
What is the cheapest month to book a flight from Buffalo to Knoxville?
Currently, June is the cheapest month in which you can book a flight from Buffalo to Knoxville (average of $344). Flying from Buffalo to Knoxville in February is currently the most expensive (average of $646). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Buffalo to Knoxville?
Airfare is below average for this route at the moment.
Buffalo to Knoxville flights typically cost between $286 and $430 in December.The cheapest round-trip price found within the last 5 days was $251 on Delta (Dec 9-Dec 22).
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated October 22, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Buffalo to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Overall
7.8
Boarding
8.1
Food
7.2
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Crew
8.5
Overall
7.8
Boarding
8.1
Food
7.2
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Crew
8.5
Overall
7.8
Boarding
8.1
Food
7.2
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Crew
8.5
Overall
7.8
Boarding
8.1
Food
7.2
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Related info for your journey
Find useful and relevant information for your journey from Buffalo to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Newport
Bryson City
Murphy
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Knoxville flight routes
Other flight options
Other flights from Buffalo
Popular flights
Alternative routes for Buffalo to Knoxville
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Knoxville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Buffalo to Knoxville by cabin class
Find flights from Buffalo to Knoxville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 22, 2026.
Buffalo and Knoxville flights
Browse other Buffalo and Knoxville flight options. Last updated on October 22, 2026.
Other flights from Buffalo
Browse through other flights departing from Buffalo. Flights are based on user searches made on Cheapflights and were last updated on October 22, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Buffalo to Knoxville
Discover the top 3 airlines that operate flights from Buffalo to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$250 | Average$406 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$278 | Average$387 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$286 | Average$411 | FlexibilityNo cancel fee | On-time69% |