$151+ Cheap flights from Buffalo to Knoxville (BUF - TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/26. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — TYS
Jul 10 — Jul 171
Round-trip
1 adult, Economy
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Cheapest flights from Buffalo to KnoxvilleExplore the most affordable flight options available from Buffalo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 10, 2026.
Explore the most affordable flight options available from Buffalo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 10, 2026.
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/305:30 am
BUF
- TYS
1 stop5h 08m
American Airlines
Mon 10/51:26 pm
TYS
- BUF
1 stop4h 21m
American Airlines
Deal found 6/8![American Airlines logo]()
$256
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/99:33 pm
BUF
- TYS
1 stop25h 11m
Multiple Airlines
Fri 8/1412:50 pm
TYS
- BUF
2 stops22h 43m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$269
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:59 pm
BUF
- TYS
1 stop3h 59m
American Airlines
Mon 8/176:57 am
TYS
- BUF
1 stop5h 41m
American Airlines
Deal found 6/9![American Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/3011:29 am
BUF
- TYS
2 stops29h 13m
Multiple Airlines
Mon 8/310:05 pm
TYS
- BUF
1 stop21h 01m
Multiple Airlines
Deal found 6/5![Multiple Airlines logo]()
$285
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:40 am
BUF
- TYS
2 stops7h 45m
Southwest
Mon 8/1712:40 pm
TYS
- BUF
1 stop10h 00m
Southwest
Deal found 6/9![Southwest logo]()
$291
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/47:35 pm
BUF
- TYS
1 stop4h 16m
American Airlines
Sat 8/84:22 pm
TYS
- BUF
1 stop5h 33m
American Airlines
Deal found 6/8![American Airlines logo]()
$295
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:00 am
BUF
- TYS
1 stop5h 48m
American Airlines
Tue 7/76:30 pm
TYS
- BUF
1 stop5h 23m
American Airlines
Deal found 6/9![American Airlines logo]()
$307
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/149:09 pm
BUF
- TYS
1 stop21h 16m
Multiple Airlines
Sat 7/1812:54 pm
TYS
- BUF
2 stops21h 35m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$308
This Southwest deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:30 am
BUF
- TYS
2 stops9h 15m
Southwest
Tue 10/138:55 am
TYS
- BUF
1 stop5h 55m
Southwest
Deal found 6/4![Southwest logo]()
$312
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/242:48 pm
BUF
- TYS
2 stops17h 44m
Multiple Airlines
Mon 7/277:20 pm
TYS
- BUF
1 stop23h 46m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$316
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:50 am
BUF
- TYS
1 stop6h 15m
Southwest
Mon 10/512:50 pm
TYS
- BUF
2 stops11h 20m
Southwest
Deal found 6/8![Southwest logo]()
$317
Best flights from Buffalo to KnoxvilleDiscover carefully curated flight deals from Buffalo to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 10, 2026.
Discover carefully curated flight deals from Buffalo to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 10, 2026.
This Southwest deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/74:35 pm
BUF
- TYS
1 stop4h 40m
Southwest
Wed 10/148:55 am
TYS
- BUF
1 stop3h 45m
Southwest
Deal found 6/4![Southwest logo]()
$307
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/149:09 pm
BUF
- TYS
1 stop21h 16m
Multiple Airlines
Sat 7/1812:54 pm
TYS
- BUF
2 stops21h 35m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$308
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:59 pm
BUF
- TYS
1 stop3h 59m
American Airlines
Sun 8/96:32 pm
TYS
- BUF
1 stop5h 24m
American Airlines
Deal found 6/9![American Airlines logo]()
$346
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/248:55 am
BUF
- TYS
1 stop6h 24m
Delta
Mon 7/275:23 pm
TYS
- BUF
1 stop6h 35m
Delta
Deal found 6/8![Delta logo]()
$357
This United Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/2310:57 am
BUF
- TYS
1 stop6h 03m
United Airlines
Sun 7/265:45 am
TYS
- BUF
1 stop4h 06m
United Airlines
Deal found 6/6![United Airlines logo]()
$407
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1410:25 am
BUF
- TYS
2 stops10h 55m
Southwest
Sat 7/181:35 pm
TYS
- BUF
2 stops9h 40m
Southwest
Deal found 6/9![Southwest logo]()
$342
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/173:45 pm
BUF
- TYS
1 stop3h 55m
Southwest
Sat 10/247:50 am
TYS
- BUF
1 stop6h 20m
Southwest
Deal found 6/5![Southwest logo]()
$345
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:40 am
BUF
- TYS
2 stops7h 45m
Southwest
Mon 8/178:25 am
TYS
- BUF
2 stops12h 25m
Southwest
Deal found 6/9![Southwest logo]()
$355
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/412:00 pm
BUF
- TYS
2 stops6h 55m
Southwest
Sat 8/812:30 pm
TYS
- BUF
1 stop8h 00m
Southwest
Deal found 6/8![Southwest logo]()
$362
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/47:15 am
BUF
- TYS
2 stops12h 05m
Southwest
Sat 7/111:35 pm
TYS
- BUF
2 stops9h 40m
Southwest
Deal found 6/5![Southwest logo]()
$384
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:00 am
BUF
- TYS
1 stop11h 10m
Southwest
Sun 9/68:55 am
TYS
- BUF
2 stops12h 05m
Southwest
Deal found 6/9![Southwest logo]()
$408
Last-minute flights from Buffalo to KnoxvilleDiscover last-minute flight deals from Buffalo to Knoxville. Data last updated June 10, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to Knoxville. Data last updated June 10, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:00 am
BUF
- TYS
1 stop5h 48m
American Airlines
Tue 7/76:30 pm
TYS
- BUF
1 stop5h 23m
American Airlines
Deal found 6/9![American Airlines logo]()
$307
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/306:25 am
BUF
- TYS
1 stop10h 35m
Southwest
Tue 7/712:45 pm
TYS
- BUF
2 stops10h 00m
Southwest
Deal found 6/9![Southwest logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/29:02 pm
BUF
- TYS
1 stop26h 31m
Multiple Airlines
Mon 7/67:20 pm
TYS
- BUF
2 stops15h 09m
Multiple Airlines
Deal found 6/5![Multiple Airlines logo]()
$336
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/32:50 pm
BUF
- TYS
2 stops32h 07m
Multiple Airlines
Fri 7/1010:05 pm
TYS
- BUF
1 stop23h 02m
Multiple Airlines
Deal found 6/5![Multiple Airlines logo]()
$332
This United Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:15 am
BUF
- TYS
1 stop4h 27m
United Airlines
Sat 7/117:19 pm
TYS
- BUF
1 stop4h 40m
United Airlines
Deal found 6/5![United Airlines logo]()
$337
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/149:09 pm
BUF
- TYS
1 stop21h 16m
Multiple Airlines
Sat 7/1812:54 pm
TYS
- BUF
2 stops21h 35m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$308
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1410:25 am
BUF
- TYS
2 stops10h 55m
Southwest
Sat 7/181:35 pm
TYS
- BUF
2 stops9h 40m
Southwest
Deal found 6/9![Southwest logo]()
$342
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/242:48 pm
BUF
- TYS
2 stops17h 44m
Multiple Airlines
Mon 7/277:20 pm
TYS
- BUF
1 stop23h 46m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$316
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/292:48 pm
BUF
- TYS
2 stops24h 00m
Multiple Airlines
Sun 8/26:54 pm
TYS
- BUF
1 stop24h 12m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$338
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/3011:29 am
BUF
- TYS
2 stops29h 13m
Multiple Airlines
Mon 8/310:05 pm
TYS
- BUF
1 stop21h 01m
Multiple Airlines
Deal found 6/5![Multiple Airlines logo]()
$285
One-way flights from Buffalo to KnoxvilleSearch for one-way flight options from Buffalo to Knoxville. Find affordable one-way fares based on user searches. Data last updated June 10, 2026.
Search for one-way flight options from Buffalo to Knoxville. Find affordable one-way fares based on user searches. Data last updated June 10, 2026.
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:50 am
BUF
- TYS
2 stops11h 30m
Southwest
Deal found 6/9![Southwest logo]()
$151
This Southwest deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/43:00 pm
BUF
- TYS
1 stop4h 50m
Southwest
Deal found 6/6![Southwest logo]()
$154
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/16:25 am
BUF
- TYS
1 stop10h 35m
Southwest
Deal found 6/5![Southwest logo]()
$159
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/3011:29 am
BUF
- TYS
2 stops29h 13m
Multiple Airlines
Deal found 6/5![Multiple Airlines logo]()
$165
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/32:50 pm
BUF
- TYS
2 stops32h 07m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$168
This Southwest deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/47:15 am
BUF
- TYS
2 stops12h 05m
Southwest
Deal found 6/7![Southwest logo]()
$170
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/305:55 pm
BUF
- TYS
1 stop4h 40m
Southwest
Deal found 6/5![Southwest logo]()
$179
This Southwest deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:55 pm
BUF
- TYS
1 stop4h 35m
Southwest
Deal found 6/6![Southwest logo]()
$190
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/261:16 pm
BUF
- TYS
3 stops27h 32m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$218
Find flight deals from Buffalo to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $256 (American Airlines) |
One-way from | $151 (Southwest) |
Popular in | January |
Cheapest in | August |
Average price | $341 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 10, 2026.
Use the filters below to find and compare flights from Buffalo to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Wed 10/7
4:35 pm-9:15 pm
1 stop4h 40m
Knoxville McGhee Tyson
Wed 10/14
8:55 am-12:40 pm
1 stop3h 45m
$307
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Tue 7/14
9:09 pm-6:25 pm
1 stop21h 16m
Knoxville McGhee Tyson
Sat 7/18
12:54 pm-10:29 am
2 stops21h 35m
$308
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Tue 7/14
10:25 am-9:20 pm
2 stops10h 55m
Knoxville McGhee Tyson
Sat 7/18
1:35 pm-11:15 pm
2 stops9h 40m
$342
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Sat 10/17
3:45 pm-7:40 pm
1 stop3h 55m
Knoxville McGhee Tyson
Sat 10/24
7:50 am-2:10 pm
1 stop6h 20m
$345
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Thu 8/6
6:59 pm-10:58 pm
1 stop3h 59m
Knoxville McGhee Tyson
Sun 8/9
6:32 pm-11:56 pm
1 stop5h 24m
$346
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Thu 8/13
5:40 am-1:25 pm
2 stops7h 45m
Knoxville McGhee Tyson
Mon 8/17
8:25 am-8:50 pm
2 stops12h 25m
$355
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Fri 7/24
8:55 am-3:19 pm
1 stop6h 24m
Knoxville McGhee Tyson
Mon 7/27
5:23 pm-11:58 pm
1 stop6h 35m
$357
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Tue 8/4
12:00 pm-6:55 pm
2 stops6h 55m
Knoxville McGhee Tyson
Sat 8/8
12:30 pm-8:30 pm
1 stop8h 00m
$362
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Sat 7/4
7:15 am-7:20 pm
2 stops12h 05m
Knoxville McGhee Tyson
Sat 7/11
1:35 pm-11:15 pm
2 stops9h 40m
$384
BuffaloKnoxville
BUF - TYS
BUFTYS
Buffalo
Thu 7/23
10:57 am-5:00 pm
1 stop6h 03m
Knoxville McGhee Tyson
Sun 7/26
5:45 am-9:51 am
1 stop4h 06m
$407
Showing 1-10 of 20 resultsSorted by cheapest first
Compare providers for flights from Buffalo to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Knoxville in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Buffalo-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Buffalo-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Buffalo-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Buffalo-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Buffalo to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Buffalo with our price prediction graph.
BUF-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to Knoxville
What is the cheapest month to book a flight from Buffalo to Knoxville?
Currently, August is the cheapest month in which you can book a flight from Buffalo to Knoxville (average of $338). Flying from Buffalo to Knoxville in January is currently the most expensive (average of $637). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Buffalo to Knoxville?
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated June 10, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Buffalo to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Comfort
7.8
Food
7.2
Overall
7.9
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Crew
8.5
Comfort
7.8
Food
7.2
Overall
7.9
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Crew
8.5
Comfort
7.8
Food
7.2
Overall
7.9
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Crew
8.5
Comfort
7.8
Food
7.2
Overall
7.9
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Related info for your journey
Find useful and relevant information for your journey from Buffalo to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Oak Ridge
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 10, 2026.
Buffalo and Knoxville flights
Browse other Buffalo and Knoxville flight options. Last updated on June 10, 2026.
Other flights from Buffalo
Browse through other flights departing from Buffalo. Flights are based on user searches made on Cheapflights and were last updated on June 10, 2026.
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Top 3 airlines flying from Buffalo to Knoxville
Discover the top 3 airlines that operate flights from Buffalo to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$248 | Average$376 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$250 | Average$401 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$346 | Average$411 | FlexibilityNo cancel fee | On-time69% |