$125+ Cheap flights from Buffalo to Knoxville (BUF - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/24. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — TYS
Oct 8 — Oct 151
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Buffalo to Knoxville
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Best
Last-minute
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Cheapest flights from Buffalo to KnoxvilleExplore the most affordable flight options available from Buffalo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 8, 2026.
Explore the most affordable flight options available from Buffalo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 8, 2026.
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/34:31 pm -
1 stop6h 19m
Sat 10/106:05 pm -
1 stop5h 27m
Deal found 9/3![American Airlines logo]()
$287
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:00 am -
2 stops8h 48m
Thu 12/31:05 pm -
1 stop7h 39m
Deal found 9/3![United Airlines logo]()
$292
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:59 pm -
1 stop4h 00m
Sat 10/106:00 am -
2 stops9h 10m
Deal found 9/3![United Airlines logo]()
$335
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:55 pm -
1 stop5h 04m
Mon 10/266:23 pm -
1 stop5h 36m
Deal found 9/3![Delta logo]()
$347
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:51 pm -
1 stop19h 51m
Tue 10/137:04 pm -
2 stops17h 55m
Deal found 9/4![Multiple Airlines logo]()
$349
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:00 am -
1 stop4h 25m
Sun 11/16:50 am -
1 stop3h 50m
Deal found 9/7![American Airlines logo]()
$355
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:59 pm -
1 stop4h 56m
Mon 10/55:28 pm -
1 stop6h 25m
Deal found 9/6![Delta logo]()
$363
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:01 pm -
1 stop4h 35m
Tue 11/35:45 am -
1 stop4h 09m
Deal found 9/7![United Airlines logo]()
$367
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/31:48 pm -
1 stop7h 01m
Wed 10/76:00 am -
2 stops8h 23m
Deal found 9/3![United Airlines logo]()
$372
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2212:53 pm -
1 stop23h 21m
Sun 10/256:00 am -
2 stops11h 52m
Deal found 9/7![Multiple Airlines logo]()
$375
Best flights from Buffalo to KnoxvilleDiscover carefully curated flight deals from Buffalo to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 8, 2026.
Discover carefully curated flight deals from Buffalo to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 8, 2026.
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/277:52 pm -
1 stop4h 07m
Tue 12/16:20 am -
1 stop4h 21m
Deal found 9/7![United Airlines logo]()
$343
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:00 am -
1 stop4h 25m
Sun 11/16:50 am -
1 stop3h 50m
Deal found 9/7![American Airlines logo]()
$355
This Delta deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:00 am -
1 stop4h 54m
Tue 10/136:23 pm -
1 stop5h 36m
Deal found 9/4![Delta logo]()
$363
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/134:25 pm -
1 stop3h 45m
Sat 10/176:40 am -
2 stops7h 55m
Deal found 9/3![Southwest logo]()
$363
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2212:53 pm -
1 stop23h 21m
Sun 10/256:00 am -
2 stops11h 52m
Deal found 9/7![Multiple Airlines logo]()
$375
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:00 am -
1 stop6h 14m
Sat 10/1010:42 am -
1 stop6h 01m
Deal found 9/4![United Airlines logo]()
$343
This Delta deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1212:15 pm -
1 stop6h 09m
Fri 10/165:40 am -
1 stop5h 36m
Deal found 9/5![Delta logo]()
$363
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:59 pm -
1 stop4h 00m
Wed 9/305:45 am -
2 stops9h 25m
Deal found 9/4![United Airlines logo]()
$348
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:01 pm -
1 stop4h 35m
Tue 11/35:45 am -
1 stop4h 09m
Deal found 9/7![United Airlines logo]()
$367
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/31:48 pm -
1 stop7h 01m
Wed 10/76:00 am -
2 stops8h 23m
Deal found 9/3![United Airlines logo]()
$372
Last-minute flights from Buffalo to KnoxvilleDiscover last-minute flight deals from Buffalo to Knoxville. Data last updated September 8, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to Knoxville. Data last updated September 8, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:59 pm -
1 stop4h 56m
Mon 10/55:28 pm -
1 stop6h 25m
Deal found 9/6![Delta logo]()
$363
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:00 am -
1 stop6h 07m
Wed 10/76:00 am -
1 stop4h 18m
Deal found 9/3![American Airlines logo]()
$287
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:59 pm -
1 stop4h 00m
Sat 10/106:00 am -
2 stops9h 10m
Deal found 9/3![United Airlines logo]()
$335
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/31:48 pm -
1 stop7h 01m
Wed 10/76:00 am -
2 stops8h 23m
Deal found 9/3![United Airlines logo]()
$372
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:51 pm -
1 stop19h 51m
Tue 10/137:04 pm -
2 stops17h 55m
Deal found 9/4![Multiple Airlines logo]()
$349
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2212:53 pm -
1 stop23h 21m
Sun 10/256:00 am -
2 stops11h 52m
Deal found 9/7![Multiple Airlines logo]()
$375
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:55 pm -
1 stop5h 04m
Mon 10/266:23 pm -
1 stop5h 36m
Deal found 9/3![Delta logo]()
$347
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/232:50 pm -
1 stop6h 45m
Mon 10/267:25 pm -
2 stops13h 00m
Deal found 9/3![Southwest logo]()
$378
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:00 am -
1 stop4h 25m
Sun 11/16:50 am -
1 stop3h 50m
Deal found 9/7![American Airlines logo]()
$355
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:01 pm -
1 stop4h 35m
Tue 11/35:45 am -
1 stop4h 09m
Deal found 9/7![United Airlines logo]()
$367
One-way flights from Buffalo to KnoxvilleSearch for one-way flight options from Buffalo to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 8, 2026.
Search for one-way flight options from Buffalo to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 8, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/241:44 pm -
2 stops27h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Multiple Airlines logo]()
$125
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:15 am -
1 stop4h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Delta logo]()
$172
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:47 pm -
2 stops28h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Multiple Airlines logo]()
$198
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/251:40 pm -
2 stops26h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Multiple Airlines logo]()
$207
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/69:45 am -
2 stops6h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Southwest logo]()
$229
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/207:42 pm -
1 stop4h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![American Airlines logo]()
$254
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2012:40 pm -
2 stops9h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Southwest logo]()
$269
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:59 pm -
1 stop4h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![United Airlines logo]()
$290
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:00 am -
1 stop4h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![United Airlines logo]()
$309
Find flight deals from Buffalo to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 8, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $287 (American Airlines) |
One-way from | $125 (Kiwi.com) |
Popular in | February |
Cheapest in | June |
Average price | $376 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 8, 2026.
Use the filters below to find and compare flights from Buffalo to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
BuffaloKnoxville
BUF Buffalo - TYS Knoxville McGhee Tyson
BUFTYS
Buffalo
Tue 10/6
6:15 am-10:20 am
1 stop4h 05m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$172
BuffaloKnoxville
BUF Buffalo - TYS Knoxville McGhee Tyson
BUFTYS
Buffalo
Sat 10/24
3:40 pm-7:40 pm
1 stop4h 00m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$172
BuffaloKnoxville
BUF Buffalo - TYS Knoxville McGhee Tyson
BUFTYS
Buffalo
Thu 9/24
12:49 pm-1:04 pm
3 stops48h 15m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$224
BuffaloKnoxville
BUF Buffalo - TYS Knoxville McGhee Tyson
BUFTYS
Buffalo
Sun 12/20
12:40 pm-10:35 pm
2 stops9h 55m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$269
Quickest round-trip
BuffaloKnoxville
BUF Buffalo - TYS Knoxville McGhee Tyson
BUFTYS
Buffalo
Fri 9/25
5:44 pm-9:40 pm
1 stop3h 56m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$290
BuffaloKnoxville
BUF Buffalo - TYS Knoxville McGhee Tyson
BUFTYS
Buffalo
Fri 9/25
7:59 pm-11:59 pm
1 stop4h 00m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$290
BuffaloKnoxville
BUF Buffalo - TYS Knoxville McGhee Tyson
BUFTYS
Buffalo
Thu 9/24
6:00 am-10:37 am
1 stop4h 37m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$309
BuffaloKnoxville
BUF Buffalo - TYS Knoxville McGhee Tyson
BUFTYS
Buffalo
Fri 11/27
7:52 pm-11:59 pm
1 stop4h 07m
Knoxville McGhee Tyson
Tue 12/1
6:20 am-10:41 am
1 stop4h 21m
$343
BuffaloKnoxville
BUF Buffalo - TYS Knoxville McGhee Tyson
BUFTYS
Buffalo
Sat 10/3
7:00 am-1:14 pm
1 stop6h 14m
Knoxville McGhee Tyson
Sat 10/10
10:42 am-4:43 pm
1 stop6h 01m
$343
BuffaloKnoxville
BUF Buffalo - TYS Knoxville McGhee Tyson
BUFTYS
Buffalo
Sat 9/26
7:59 pm-11:59 pm
1 stop4h 00m
Knoxville McGhee Tyson
Wed 9/30
5:45 am-3:10 pm
2 stops9h 25m
$348
Showing 1-10 of 17 resultsSorted by cheapest first
Compare providers for flights from Buffalo to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Knoxville in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Buffalo-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Buffalo-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Buffalo-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Buffalo-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Buffalo to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Buffalo with our price prediction graph.
BUF-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to Knoxville
What is the cheapest month to book a flight from Buffalo to Knoxville?
Currently, June is the cheapest month in which you can book a flight from Buffalo to Knoxville (average of $344). Flying from Buffalo to Knoxville in February is currently the most expensive (average of $646). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Buffalo to Knoxville?
Airfare is below average for this route at the moment.
Buffalo to Knoxville flights typically cost between $373 and $489 in October.The cheapest round-trip price found within the last 5 days was $287 on United Airlines (Oct 3-Oct 10).
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 8, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Buffalo to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Food
7.2
Comfort
7.8
Overall
7.8
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Boarding
8.1
Food
7.2
Comfort
7.8
Overall
7.8
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Boarding
8.1
Food
7.2
Comfort
7.8
Overall
7.8
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Boarding
8.1
Food
7.2
Comfort
7.8
Overall
7.8
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Related info for your journey
Find useful and relevant information for your journey from Buffalo to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
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Alternative routes for Buffalo to Knoxville
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 8, 2026.
Buffalo and Knoxville flights
Browse other Buffalo and Knoxville flight options. Last updated on September 8, 2026.
Other flights from Buffalo
Browse through other flights departing from Buffalo. Flights are based on user searches made on Cheapflights and were last updated on September 8, 2026.
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Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Buffalo to Knoxville
Discover the top 3 airlines that operate flights from Buffalo to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 8, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$250 | Average$401 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$268 | Average$408 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$346 | Average$411 | FlexibilityNo cancel fee | On-time69% |